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HLA-DQ2/DQ8
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Additional Topics Details for this Page
Article Count
- 5
Cumulative Knowledge
- 24
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Quick Summary: 2 associated Problem Substances
Name
Cumulative Knowledge
Article Count
Focus Articles
Gliadin
2
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Gluten
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Quick Summary: 1 associated Diseases
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Celiac Disease
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View the Evidence:
HLA-DQ2/8 genes may not cause gluten-associated villous atrophy, rather, be activated as a consequence of the pathological process.
Click here to read the entire abstract
Pubmed Data
: Clin Chem Lab Med. 2005 ;43(7):685-95. PMID:
16207126
Article Published Date
: Dec 31, 2004
Study Type
: Human Study
Additional Links
Diseases
:
Celiac Disease : CK(1527) : AC(215)
Pharmacological Actions
:
Antiproliferative : CK(1052) : AC(775)
,
Apoptotic : CK(1489) : AC(1114)
Additional Keywords
:
HLA-DQ2/DQ8 : CK(24) : AC(5)
,
Questions Of Causality : CK(10) : AC(1)
Results indicate that the major genetic susceptibility locus, HLA DQ, does not determine the exact clinical outcome of coeliac disease.
Click here to read the entire abstract
Pubmed Data
: Dig Liver Dis. 2002 Dec ;34(12):842-5. PMID:
12643291
Article Published Date
: Nov 30, 2002
Study Type
: Human Study
Additional Links
Diseases
:
Celiac Disease : CK(1527) : AC(215)
Additional Keywords
:
HLA-DQ2/DQ8 : CK(24) : AC(5)
Retinoic Acid (a Vitamin A metabolite) in conjunction with IL-15 promotes rather than prevents Inflammation in Celiacs
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nature. 2011 Mar 10 ;471(7337):220-4. Epub 2011 Feb 9. PMID:
21307853
Article Published Date
: Mar 09, 2011
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Vitamin A : CK(371) : AC(58)
Diseases
:
Celiac Disease : CK(1527) : AC(215)
Additional Keywords
:
Celiac Disease : CK(4) : AC(2)
,
HLA-DQ2/DQ8 : CK(24) : AC(5)
,
IL-15 : CK(4) : AC(2)
Problem Substances
:
Gliadin : CK(2509) : AC(110)
,
Gluten : CK(1755) : AC(144)
Adverse Pharmacological Actions
:
Inflammatory : CK(150) : AC(37)
Celiac disease: strong association to HLA and 39 nonHLA risk genes, mostly immune-related
Click here to read the entire abstract
Pubmed Data
: Trends Mol Med. 2010 Nov ;16(11):537-50. Epub 2010 Oct 12. PMID:
20947431
Article Published Date
: Oct 31, 2010
Study Type
: Review
Additional Links
Diseases
:
Autoimmune Diseases : CK(5317) : AC(779)
,
Celiac Disease : CK(1527) : AC(215)
Therapeutic Actions
:
Dietary Modification: Wheat/Gluten Free : CK(259) : AC(29)
Additional Keywords
:
Genetic testing
,
HLA-DQ2/DQ8 : CK(24) : AC(5)
,
intestinal inflammation
Problem Substances
:
Gluten : CK(1755) : AC(144)
GFD beneficial in HLA-related celiac disease with epilepsy and cerebral calcifications
Click here to read the entire abstract
Pubmed Data
: Brain Dev. 2005 Apr ;27(3):189-200. PMID:
15737700
Article Published Date
: Mar 31, 2005
Study Type
: Review
Additional Links
Diseases
:
Celiac Disease : CK(1527) : AC(215)
,
Epilepsy: With Cerebral Calcifications : CK(24) : AC(3)
Therapeutic Actions
:
Dietary Modification: Wheat/Gluten Free : CK(259) : AC(29)
Additional Keywords
:
HLA-DQ2/DQ8 : CK(24) : AC(5)
,
Seizures
Problem Substances
:
Gliadin : CK(2509) : AC(110)
,
Gluten : CK(1755) : AC(144)
Related Blogs
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603
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Are grains toxic for everyone? Is gluten-free enough to protect your health?
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