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Selective Cytotoxicity

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Article Count - 41
Cumulative Knowledge - 60

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Quick Summary: Current access displays 2 out of 30 associated Diseases

Name	Cumulative Knowledge	Article Count	Focus Articles
Cancers: All	7	7	Log in \| Sign up
Tumors	5	5	Log in \| Sign up

Quick Summary: Current access displays 2 out of 33 associated Substances

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Curcumin	6	5	Log in \| Sign up
Shiitake Mushroom	3	2	Log in \| Sign up

Quick Summary: Current access displays 2 out of 16 associated Pharmacological Actions

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View the Evidence:

Dandelion root induces selective apoptosis and autophagy in human pancreatic cancer cells in a dose and time dependent manner.

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Pubmed Data : Pancreas. 2012 Oct ;41(7):1039-47. PMID: 22647733

Article Published Date : Sep 30, 2012

Study Type : Human In Vitro

Additional Links

Substances : Dandelion : CK(91) : AC(30)

Diseases : Pancreatic Cancer : CK(530) : AC(168)

Pharmacological Actions : Apoptotic : CK(1535) : AC(1155), Autophagy Up-regulation : CK(18) : AC(13)

Additional Keywords : Selective Cytotoxicity : CK(58) : AC(41)

Human bladder cancer cells and immortalized normal bladder cells were studied using Frankincense oil; Frankincense oil appears to distinguish cancerous from normal bladder cells and suppress cancer cell viability.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2009 ;9:6. Epub 2009 Mar 18. PMID: 19296830

Article Published Date : Dec 31, 2008

Study Type : Human In Vitro

Additional Links

Substances : Frankincense : CK(22) : AC(1)

Diseases : Bladder Cancer : CK(186) : AC(60)

Pharmacological Actions : Apoptotic : CK(1535) : AC(1155), Cell cycle arrest : CK(390) : AC(319)

Additional Keywords : Plant Extracts : CK(3616) : AC(1226), Selective Cytotoxicity : CK(58) : AC(41)

This study compares Boswellia sacra essential oil hydrodistilled at 100 °C vs 78 °C in inducing cancer cell death in cultured breast cancer cells; the oil prepared at 100 °C was more potent in inducing breast cancer cell-specific cytotoxicity.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2011 ;11:129. Epub 2011 Dec 15. PMID: 22171782

Article Published Date : Dec 31, 2010

Study Type : Human In Vitro

Additional Links

Substances : Frankincense : CK(22) : AC(1)

Diseases : Breast Cancer : CK(2361) : AC(621), Cancer Metastasis : CK(272) : AC(135)

Pharmacological Actions : Antiproliferative : CK(1058) : AC(775), Apoptotic : CK(1535) : AC(1155), Cell cycle arrest : CK(390) : AC(319)

Additional Keywords : Selective Cytotoxicity : CK(58) : AC(41)

"A Novel Curcumin-based Vaginal Cream Vacurin Selectively Eliminates Apposed Human Cervical Cancer Cells.:

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Pubmed Data : Gynecol Oncol. 2012 Dec 9. Epub 2012 Dec 9. PMID: 23234806

Article Published Date : Dec 08, 2012

Study Type : Animal Study

Additional Links

Substances : Turmeric: Topical : CK(1) : AC(1)

Diseases : Cervical Cancer : CK(368) : AC(69)

Additional Keywords : Selective Cytotoxicity : CK(58) : AC(41)

An ethanol extract of Shitake (Lentinula elodes) selectively kills skin cancer cells in mice.

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Pubmed Data : Cancer Lett. 2005 Mar 18;220(1):21-8. PMID: 15737684

Article Published Date : Mar 18, 2005

Study Type : Animal Study

Additional Links

Substances : Shiitake Mushroom : CK(24) : AC(17)

Diseases : Skin Cancer : CK(417) : AC(171)

Pharmacological Actions : Apoptotic : CK(1535) : AC(1155), Cell cycle arrest : CK(390) : AC(319)

Additional Keywords : Antiproliferative : CK(5) : AC(3), Selective Cytotoxicity : CK(58) : AC(41)

Artesunate, a novel derivative of artemisin, has in vitro and in vivo anticancer activity against pancreatic cancer. It exhibits selective cytotoxicity and has in vivo antitumor activity similar to that of gemcitabine.

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Pubmed Data : Cancer Chemother Pharmacol. 2010 Apr;65(5):895-902. Epub 2009 Aug 19. PMID: 19690861

Article Published Date : Apr 01, 2010

Study Type : Animal Study

Additional Links

Substances : Artemisinin : CK(59) : AC(13)

Diseases : Pancreatic Cancer : CK(530) : AC(168)

Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Apoptotic : CK(1535) : AC(1155)

Additional Keywords : Drug: Gemcitabine : CK(36) : AC(13), Selective Cytotoxicity : CK(58) : AC(41), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Crocin from Saffron (Crocus sativus) possesses significant anti-proliferation effects on human colorectal cancer cells.

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Pubmed Data : Exp Oncol. 2007 Sep;29(3):175-80. PMID: 18004240

Article Published Date : Sep 01, 2007

Study Type : Animal Study

Additional Links

Substances : Carotenoids : CK(1055) : AC(213), Saffron : CK(135) : AC(34)

Diseases : Colorectal Cancer : CK(877) : AC(321)

Pharmacological Actions : Antiproliferative : CK(1058) : AC(775)

Additional Keywords : Selective Cytotoxicity : CK(58) : AC(41)

Solanum nigrum selectively inhibits human cervical cancer cells and cervical tumors in mice.

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Pubmed Data : J Atheroscler Thromb. 2002;9(3):149-56. PMID: 18717490

Article Published Date : Jan 01, 2002

Study Type : Animal Study

Additional Links

Substances : Solanum nigrum (black nightshade) : CK(24) : AC(14)

Diseases : Cervical Cancer : CK(368) : AC(69)

Pharmacological Actions : Antiproliferative : CK(1058) : AC(775), Apoptotic : CK(1535) : AC(1155)

Additional Keywords : Selective Cytotoxicity : CK(58) : AC(41)

The curry spice curcumin selectively inhibits cancer cells growth in vitro and in preclinical model of glioblastoma.

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Pubmed Data : J Nutr Biochem. 2011 Jul 18. Epub 2011 Jul 18. PMID: 21775121

Article Published Date : Jul 18, 2011

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2923) : AC(1482)

Diseases : Glioma : CK(74) : AC(40)

Pharmacological Actions : Chemopreventive : CK(1528) : AC(382)

Additional Keywords : Selective Cytotoxicity : CK(58) : AC(41)

Aloe-emodin may have therapeutic activity in skin cancer.

Click here to read the entire abstract

Pubmed Data : Chem Res Toxicol. 2009 Dec;22(12):2017-28. PMID: 19928967

Article Published Date : Dec 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Aloe Vera : CK(201) : AC(44), Emodin : CK(32) : AC(19)

Diseases : Skin Cancer : CK(417) : AC(171), Skin Cancer: Squamous Cell : CK(52) : AC(16)

Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Apoptotic : CK(1535) : AC(1155), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348), Tumor Suppressor Protein p53 Upregulation : CK(163) : AC(105)

Additional Keywords : Drug: 5-flourouracil : CK(88) : AC(22), Selective Cytotoxicity : CK(58) : AC(41)

Ashwaganda leaf extract exhibits selective killing of cancer cells.

Click here to read the entire abstract

Pubmed Data : Mol Carcinog. 2006 May;45(5):320-32. PMID: 17404115

Article Published Date : May 01, 2006

Study Type : In Vitro Study

Additional Links

Substances : Ashwagandha : CK(137) : AC(63)

Diseases : Tumors : CK(197) : AC(110)

Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Apoptotic : CK(1535) : AC(1155), Tumor Suppressor Protein p53 Upregulation : CK(163) : AC(105)

Additional Keywords : Plant Extracts : CK(3616) : AC(1226), Selective Cytotoxicity : CK(58) : AC(41)

Ashwaganda selectively kills cancer cells.

Click here to read the entire abstract

Pubmed Data : PLoS One. 2010;5(10):e13536. Epub 2010 Oct 21. PMID: 20975835

Article Published Date : Jan 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Ashwagandha : CK(137) : AC(63)

Diseases : Cancers: All : CK(9062) : AC(2869)

Additional Keywords : Selective Cytotoxicity : CK(58) : AC(41)

Berberine exhibits preferential selectivity toward pancreatic cancer cells compared to normal ones.

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Pubmed Data : Planta Med. 2010 May 7. Epub 2010 May 7. PMID: 20455200

Article Published Date : May 07, 2010

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Pancreatic Cancer : CK(530) : AC(168)

Additional Keywords : Selective Cytotoxicity : CK(58) : AC(41)

Berberine induces cell cycle arrest and programmed cell death in human prostate cancer cells.

Click here to read the entire abstract

Pubmed Data : Mol Cancer Ther. 2006 Feb;5(2):296-308. PMID: 16505103

Article Published Date : Feb 01, 2006

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Prostate Cancer : CK(998) : AC(288)

Pharmacological Actions : Antiproliferative : CK(1058) : AC(775), Apoptotic : CK(1535) : AC(1155), Cell cycle arrest : CK(390) : AC(319)

Additional Keywords : Selective Cytotoxicity : CK(58) : AC(41)

Betulinic acid has therapeutic potential in the prevention and treatment of cancer and HIV infection.

Click here to read the entire abstract

Pubmed Data : Med Res Rev. 2004 Jan;24(1):90-114. PMID: 14595673

Article Published Date : Jan 01, 2004

Study Type : Commentary

Additional Links

Substances : Betulinic acid : CK(6) : AC(6)

Diseases : Cancers: All : CK(9062) : AC(2869), HIV Infections : CK(577) : AC(184)

Pharmacological Actions : Anti-HIV Agents : CK(108) : AC(60), Apoptotic : CK(1535) : AC(1155)

Additional Keywords : Selective Cytotoxicity : CK(58) : AC(41)

Boswellia contains compounds with significant anti-protozoa activity.

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2009 Mar;23(3):303-7. PMID: 21157686

Article Published Date : Mar 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Boswellia : CK(122) : AC(31)

Diseases : Protozoan Infections : CK(4) : AC(4)

Pharmacological Actions : Antiprotozoal Agents : CK(14) : AC(5)

Additional Keywords : Selective Cytotoxicity : CK(58) : AC(41)

Cannabinoids may be ideal candidates for the treatment of gliomas.

Click here to read the entire abstract

Pubmed Data : Neuropharmacology. 2004 Sep;47(3):315-23. PMID: 15275820

Article Published Date : Sep 01, 2004

Study Type : Review

Additional Links

Substances : Cannabinoids : CK(195) : AC(53)

Diseases : Glioma : CK(74) : AC(40)

Pharmacological Actions : Apoptotic : CK(1535) : AC(1155)

Additional Keywords : Selective Cytotoxicity : CK(58) : AC(41)

Curcumin selectively inhibits and induces programmed cell death in B-cell lymphoma cells.

Click here to read the entire abstract

Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Nov;24(11):1003-6. PMID: 15609600

Article Published Date : Nov 01, 2004

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(2923) : AC(1482)

Diseases : Lymphoma: B-Cell : CK(21) : AC(12)

Pharmacological Actions : Antiproliferative : CK(1058) : AC(775), Apoptotic : CK(1535) : AC(1155), Cell cycle arrest : CK(390) : AC(319)

Additional Keywords : Selective Cytotoxicity : CK(58) : AC(41)

Curcumin selectively inhibits tumor cells.

Click here to read the entire abstract

Pubmed Data : Mol Cancer Ther. 2004 Sep;3(9):1101-8. PMID: 15367704

Article Published Date : Sep 01, 2004

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(2923) : AC(1482)

Diseases : Tumors : CK(197) : AC(110)

Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Apoptotic : CK(1535) : AC(1155)

Additional Keywords : Selective Cytotoxicity : CK(58) : AC(41)

Curcumin selectively targets immortalized normal, leukoplakia, and malignant oral cells.

Click here to read the entire abstract

Pubmed Data : Cancer Prev Res (Phila). 2010 Mar;3(3):331-8. Epub 2010 Feb 9. PMID: 20145189

Article Published Date : Mar 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(2923) : AC(1482)

Diseases : Cancers: All : CK(9062) : AC(2869), Leukoplakia : CK(31) : AC(4), Oral Cancer : CK(66) : AC(43)

Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1058) : AC(775)

Additional Keywords : Selective Cytotoxicity : CK(58) : AC(41)

Dandelion root has a potent action against chemoresistant melanoma without toxicity to healthy cells.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2011 ;2011:129045. Epub 2010 Dec 30. PMID: 21234313

Article Published Date : Jan 01, 2011

Study Type : In Vitro Study

Additional Links

Substances : Dandelion : CK(91) : AC(30)

Diseases : Cancers: Drug Resistant : CK(225) : AC(147), Melanoma : CK(171) : AC(87)

Pharmacological Actions : Apoptotic : CK(1535) : AC(1155), Chemosensitizer : CK(197) : AC(159)

Additional Keywords : chemoresistance, Selective Cytotoxicity : CK(58) : AC(41)

Elecampane (Inula helenium) extracts exhibit highly selective cytotoxicity against tumor cell lines.

Click here to read the entire abstract

Pubmed Data : Complement Ther Clin Pract. 2010 May;16(2):81-5. Epub 2009 Aug 19. PMID: 16912983

Article Published Date : May 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Elecampane : CK(4) : AC(6)

Diseases : Tumors : CK(197) : AC(110)

Pharmacological Actions : Apoptotic : CK(1535) : AC(1155)

Additional Keywords : Plant Extracts : CK(3616) : AC(1226), Selective Cytotoxicity : CK(58) : AC(41)

Feverfew contains the compound parthenolide which selectively eradicates acute myelogenous leukemia stem and progenitor cells.

Click here to read the entire abstract

Pubmed Data : Blood. 2007 Dec 15;110(13):4427-35. Epub 2007 Sep 5. PMID: 17804695

Article Published Date : Dec 15, 2007

Study Type : In Vitro Study

Additional Links

Substances : Feverfew : CK(41) : AC(21)

Diseases : Leukemia: Acute myelogenous leukemia (AML) : CK(96) : AC(28)

Pharmacological Actions : NF-kappaB Inhibitor : CK(595) : AC(401), Tumor Suppressor Protein p53 Upregulation : CK(163) : AC(105)

Additional Keywords : Selective Cytotoxicity : CK(58) : AC(41)

Flavonoids purified from Rhus verniciflua Stokes (Sumac) exhibit selective antiproliferative and apoptotic effects on SV40-transformed liver tumor cells.

Click here to read the entire abstract

Pubmed Data : Toxicol Lett. 2005 Jan 15;155(1):115-25. PMID: 15585366

Article Published Date : Jan 15, 2005

Study Type : In Vitro Study

Additional Links

Substances : Flavonoids : CK(909) : AC(289), Sumac : CK(37) : AC(16)

Diseases : Liver Cancer : CK(1641) : AC(266), Simian virus 40 (SV40) : CK(7) : AC(5)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

Additional Keywords : Selective Cytotoxicity : CK(58) : AC(41)

Greek propolis exhibits antiproliferative effects against human colon cancer cells.

Click here to read the entire abstract

Pubmed Data : J Med Food. 2010 Feb 4. Epub 2010 Feb 4. PMID: 20132046

Article Published Date : Feb 04, 2010

Study Type : In Vitro Study

Additional Links

Substances : Bee Propolis : CK(220) : AC(83)

Diseases : Colon Cancer : CK(895) : AC(233)

Pharmacological Actions : Antiproliferative : CK(1058) : AC(775), Cell cycle arrest : CK(390) : AC(319)

Additional Keywords : Selective Cytotoxicity : CK(58) : AC(41)

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