Selective Cytotoxicity

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Quick Summary: Current access displays 2 out of 30 associated Diseases

Name	Cumulative Knowledge	Article Count	Focus Articles
Cancers: All	7	7	Log in \| Sign up
Tumors	5	5	Log in \| Sign up

Quick Summary: Current access displays 2 out of 33 associated Substances

Name	Cumulative Knowledge	Article Count	Focus Articles
Curcumin	6	5	Log in \| Sign up
Shiitake Mushroom	3	2	Log in \| Sign up

Quick Summary: Current access displays 2 out of 16 associated Pharmacological Actions

Name	Cumulative Knowledge	Article Count	Focus Articles
Apoptotic	24	21	Log in \| Sign up
Antiproliferative	13	11	Log in \| Sign up

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View the Evidence:

An ethanol extract of Shitake (Lentinula elodes) selectively kills skin cancer cells in mice.

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Pubmed Data : Cancer Lett. 2005 Mar 18;220(1):21-8. PMID: 15737684

Article Published Date : Mar 18, 2005

Study Type : Animal Study

Additional Links

Substances : Shiitake Mushroom : CK(24) : AC(17)

Diseases : Skin Cancer : CK(438) : AC(171)

Pharmacological Actions : Apoptotic : CK(1416) : AC(1089), Cell cycle arrest : CK(371) : AC(309)

Additional Keywords : Antiproliferative : CK(5) : AC(3), Selective Cytotoxicity : CK(42) : AC(37)

Artesunate, a novel derivative of artemisin, has in vitro and in vivo anticancer activity against pancreatic cancer. It exhibits selective cytotoxicity and has in vivo antitumor activity similar to that of gemcitabine.

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Pubmed Data : Cancer Chemother Pharmacol. 2010 Apr;65(5):895-902. Epub 2009 Aug 19. PMID: 19690861

Article Published Date : Apr 01, 2010

Study Type : Animal Study

Additional Links

Substances : Artemisinin : CK(59) : AC(13)

Diseases : Pancreatic Cancer : CK(513) : AC(162)

Pharmacological Actions : Antineoplastic Agents : CK(833) : AC(457), Apoptotic : CK(1416) : AC(1089)

Additional Keywords : Drug: Gemcitabine : CK(36) : AC(13), Selective Cytotoxicity : CK(42) : AC(37), Superiority of Natural Substances versus Drugs : CK(897) : AC(158)

Crocin from Saffron (Crocus sativus) possesses significant anti-proliferation effects on human colorectal cancer cells.

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Pubmed Data : Exp Oncol. 2007 Sep;29(3):175-80. PMID: 18004240

Article Published Date : Sep 01, 2007

Study Type : Animal Study

Additional Links

Substances : Carotenoids : CK(1055) : AC(213), Saffron : CK(123) : AC(32)

Diseases : Colorectal Cancer : CK(809) : AC(303)

Pharmacological Actions : Antiproliferative : CK(969) : AC(725)

Additional Keywords : Selective Cytotoxicity : CK(42) : AC(37)

Solanum nigrum selectively inhibits human cervical cancer cells and cervical tumors in mice.

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Pubmed Data : J Atheroscler Thromb. 2002;9(3):149-56. PMID: 18717490

Article Published Date : Jan 01, 2002

Study Type : Animal Study

Additional Links

Substances : Solanum nigrum (black nightshade) : CK(24) : AC(14)

Diseases : Cervical Cancer : CK(198) : AC(67)

Pharmacological Actions : Antiproliferative : CK(969) : AC(725), Apoptotic : CK(1416) : AC(1089)

Additional Keywords : Selective Cytotoxicity : CK(42) : AC(37)

The curry spice curcumin selectively inhibits cancer cells growth in vitro and in preclinical model of glioblastoma.

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Pubmed Data : J Nutr Biochem. 2011 Jul 18. Epub 2011 Jul 18. PMID: 21775121

Article Published Date : Jul 18, 2011

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2890) : AC(1511)

Diseases : Glioma : CK(72) : AC(43)

Pharmacological Actions : Chemopreventive : CK(1314) : AC(355)

Additional Keywords : Selective Cytotoxicity : CK(42) : AC(37)

Aloe-emodin may have therapeutic activity in skin cancer.

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Pubmed Data : Chem Res Toxicol. 2009 Dec;22(12):2017-28. PMID: 19928967

Article Published Date : Dec 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Aloe Vera : CK(201) : AC(44), Emodin : CK(32) : AC(19)

Diseases : Skin Cancer : CK(438) : AC(171), Skin Cancer: Squamous Cell : CK(52) : AC(16)

Pharmacological Actions : Antineoplastic Agents : CK(833) : AC(457), Apoptotic : CK(1416) : AC(1089), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1015) : AC(343), Tumor Suppressor Protein p53 Upregulation : CK(140) : AC(103)

Additional Keywords : Drug: 5-flourouracil : CK(88) : AC(22), Selective Cytotoxicity : CK(42) : AC(37)

Ashwaganda leaf extract exhibits selective killing of cancer cells.

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Pubmed Data : Mol Carcinog. 2006 May;45(5):320-32. PMID: 17404115

Article Published Date : May 01, 2006

Study Type : In Vitro Study

Additional Links

Substances : Ashwagandha : CK(137) : AC(63)

Diseases : Tumors : CK(193) : AC(110)

Pharmacological Actions : Antineoplastic Agents : CK(833) : AC(457), Apoptotic : CK(1416) : AC(1089), Tumor Suppressor Protein p53 Upregulation : CK(140) : AC(103)

Additional Keywords : Plant Extracts : CK(3401) : AC(1158), Selective Cytotoxicity : CK(42) : AC(37)

Ashwaganda selectively kills cancer cells.

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Pubmed Data : PLoS One. 2010;5(10):e13536. Epub 2010 Oct 21. PMID: 20975835

Article Published Date : Jan 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Ashwagandha : CK(137) : AC(63)

Diseases : Cancers: All : CK(8467) : AC(2708)

Additional Keywords : Selective Cytotoxicity : CK(42) : AC(37)

Berberine exhibits preferential selectivity toward pancreatic cancer cells compared to normal ones.

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Pubmed Data : Planta Med. 2010 May 7. Epub 2010 May 7. PMID: 20455200

Article Published Date : May 07, 2010

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(144) : AC(70)

Diseases : Pancreatic Cancer : CK(513) : AC(162)

Additional Keywords : Selective Cytotoxicity : CK(42) : AC(37)

Berberine induces cell cycle arrest and programmed cell death in human prostate cancer cells.

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Pubmed Data : Mol Cancer Ther. 2006 Feb;5(2):296-308. PMID: 16505103

Article Published Date : Feb 01, 2006

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(144) : AC(70)

Diseases : Prostate Cancer : CK(956) : AC(288)

Pharmacological Actions : Antiproliferative : CK(969) : AC(725), Apoptotic : CK(1416) : AC(1089), Cell cycle arrest : CK(371) : AC(309)

Additional Keywords : Selective Cytotoxicity : CK(42) : AC(37)

Betulinic acid has therapeutic potential in the prevention and treatment of cancer and HIV infection.

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Pubmed Data : Med Res Rev. 2004 Jan;24(1):90-114. PMID: 14595673

Article Published Date : Jan 01, 2004

Study Type : Commentary

Additional Links

Substances : Betulinic acid : CK(6) : AC(6)

Diseases : Cancers: All : CK(8467) : AC(2708), HIV Infections : CK(564) : AC(184)

Pharmacological Actions : Anti-HIV Agents : CK(106) : AC(57), Apoptotic : CK(1416) : AC(1089)

Additional Keywords : Selective Cytotoxicity : CK(42) : AC(37)

Boswellia contains compounds with significant anti-protozoa activity.

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Pubmed Data : Phytother Res. 2009 Mar;23(3):303-7. PMID: 21157686

Article Published Date : Mar 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Boswellia : CK(122) : AC(31)

Diseases : Protozoan Infections : CK(4) : AC(4)

Pharmacological Actions : Antiprotozoal Agents : CK(14) : AC(5)

Additional Keywords : Selective Cytotoxicity : CK(42) : AC(37)

Cannabinoids may be ideal candidates for the treatment of gliomas.

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Pubmed Data : Neuropharmacology. 2004 Sep;47(3):315-23. PMID: 15275820

Article Published Date : Sep 01, 2004

Study Type : Review

Additional Links

Substances : Cannabinoids : CK(183) : AC(53)

Diseases : Glioma : CK(72) : AC(43)

Pharmacological Actions : Apoptotic : CK(1416) : AC(1089)

Additional Keywords : Selective Cytotoxicity : CK(42) : AC(37)

Curcumin selectively inhibits and induces programmed cell death in B-cell lymphoma cells.

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Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Nov;24(11):1003-6. PMID: 15609600

Article Published Date : Nov 01, 2004

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(2890) : AC(1511)

Diseases : Lymphoma: B-Cell : CK(21) : AC(12)

Pharmacological Actions : Antiproliferative : CK(969) : AC(725), Apoptotic : CK(1416) : AC(1089), Cell cycle arrest : CK(371) : AC(309)

Additional Keywords : Selective Cytotoxicity : CK(42) : AC(37)

Curcumin selectively inhibits tumor cells.

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Pubmed Data : Mol Cancer Ther. 2004 Sep;3(9):1101-8. PMID: 15367704

Article Published Date : Sep 01, 2004

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(2890) : AC(1511)

Diseases : Tumors : CK(193) : AC(110)

Pharmacological Actions : Antineoplastic Agents : CK(833) : AC(457), Apoptotic : CK(1416) : AC(1089)

Additional Keywords : Selective Cytotoxicity : CK(42) : AC(37)

Curcumin selectively targets immortalized normal, leukoplakia, and malignant oral cells.

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Pubmed Data : Cancer Prev Res (Phila). 2010 Mar;3(3):331-8. Epub 2010 Feb 9. PMID: 20145189

Article Published Date : Mar 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(2890) : AC(1511)

Diseases : Cancers: All : CK(8467) : AC(2708), Leukoplakia : CK(31) : AC(4), Oral Cancer : CK(66) : AC(43)

Pharmacological Actions : Antineoplastic Agents : CK(833) : AC(457), Antiproliferative : CK(969) : AC(725)

Additional Keywords : Selective Cytotoxicity : CK(42) : AC(37)

Dandelion root has a potent action against chemoresistant melanoma without toxicity to healthy cells.

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Article Publish Status : This is a free article. Click here to read the entire article.

Pubmed Data : Evid Based Complement Alternat Med. 2011 ;2011:129045. Epub 2010 Dec 30. PMID: 21234313

Article Published Date : Jan 01, 2011

Study Type : In Vitro Study

Additional Links

Substances : Dandelion : CK(86) : AC(30)

Diseases : Cancers: Drug Resistant : CK(211) : AC(139), Melanoma : CK(168) : AC(87)

Pharmacological Actions : Apoptotic : CK(1416) : AC(1089), Chemosensitizer : CK(188) : AC(156)

Additional Keywords : chemoresistance, Selective Cytotoxicity : CK(42) : AC(37)

Elecampane (Inula helenium) extracts exhibit highly selective cytotoxicity against tumor cell lines.

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Pubmed Data : Complement Ther Clin Pract. 2010 May;16(2):81-5. Epub 2009 Aug 19. PMID: 16912983

Article Published Date : May 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Elecampane : CK(4) : AC(6)

Diseases : Tumors : CK(193) : AC(110)

Pharmacological Actions : Apoptotic : CK(1416) : AC(1089)

Additional Keywords : Plant Extracts : CK(3401) : AC(1158), Selective Cytotoxicity : CK(42) : AC(37)

Feverfew contains the compound parthenolide which selectively eradicates acute myelogenous leukemia stem and progenitor cells.

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Pubmed Data : Blood. 2007 Dec 15;110(13):4427-35. Epub 2007 Sep 5. PMID: 17804695

Article Published Date : Dec 15, 2007

Study Type : In Vitro Study

Additional Links

Substances : Feverfew : CK(41) : AC(21)

Diseases : Leukemia: Acute myelogenous leukemia (AML) : CK(96) : AC(28)

Pharmacological Actions : NF-kappaB Inhibitor : CK(599) : AC(397), Tumor Suppressor Protein p53 Upregulation : CK(140) : AC(103)

Additional Keywords : Selective Cytotoxicity : CK(42) : AC(37)

Flavonoids purified from Rhus verniciflua Stokes (Sumac) exhibit selective antiproliferative and apoptotic effects on SV40-transformed liver tumor cells.

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Pubmed Data : Toxicol Lett. 2005 Jan 15;155(1):115-25. PMID: 15585366

Article Published Date : Jan 15, 2005

Study Type : In Vitro Study

Additional Links

Substances : Flavonoids : CK(868) : AC(290), Sumac : CK(37) : AC(16)

Diseases : Liver Cancer : CK(1577) : AC(266), Simian virus 40 (SV40) : CK(7) : AC(5)

Pharmacological Actions : Antioxidants : CK(3503) : AC(1292)

Additional Keywords : Selective Cytotoxicity : CK(42) : AC(37)

Greek propolis exhibits antiproliferative effects against human colon cancer cells.

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Pubmed Data : J Med Food. 2010 Feb 4. Epub 2010 Feb 4. PMID: 20132046

Article Published Date : Feb 04, 2010

Study Type : In Vitro Study

Additional Links

Substances : Bee Propolis : CK(232) : AC(86)

Diseases : Colon Cancer : CK(819) : AC(233)

Pharmacological Actions : Antiproliferative : CK(969) : AC(725), Cell cycle arrest : CK(371) : AC(309)

Additional Keywords : Selective Cytotoxicity : CK(42) : AC(37)

Indole-3-carbinol exhibits selective cytotoxicity against a human breast tumor cell line.

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Pubmed Data : J Agric Food Chem. 2008 Nov 26;56(22):10544-51. PMID: 12479697

Article Published Date : Nov 26, 2008

Study Type : In Vitro Study

Additional Links

Substances : Indole-3-Carbinol : CK(32) : AC(16)

Diseases : Breast Cancer : CK(2051) : AC(566)

Pharmacological Actions : Anticarcinogenic Agents : CK(513) : AC(265), Antiproliferative : CK(969) : AC(725), Apoptotic : CK(1416) : AC(1089), NF-kappaB Inhibitor : CK(599) : AC(397)

Additional Keywords : Selective Cytotoxicity : CK(42) : AC(37)

Lichen compounds exhibit selective cytotoxicity against human cancer cells.

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Pubmed Data : Nat Prod Res. 2006 Dec;20(14):1300-7. PMID: 17393655

Article Published Date : Dec 01, 2006

Study Type : In Vitro Study

Additional Links

Substances : Lichens : CK(17) : AC(7)

Diseases : Lung Cancer : CK(494) : AC(198)

Pharmacological Actions : Antineoplastic Agents : CK(833) : AC(457)

Additional Keywords : Selective Cytotoxicity : CK(42) : AC(37)

Loquat polyphenols exhibits selective cytotoxicity against oral tumor cell lines.

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Pubmed Data : Chem Pharm Bull (Tokyo). 2000 May;48(5):687-93. PMID: 10823708

Article Published Date : May 01, 2000

Study Type : In Vitro Study

Additional Links

Substances : Loquat : CK(65) : AC(31)

Diseases : Oral Cancer : CK(66) : AC(43)

Pharmacological Actions : Apoptotic : CK(1416) : AC(1089)

Additional Keywords : Proanthocyanidins : CK(159) : AC(46), Selective Cytotoxicity : CK(42) : AC(37)

Noni has selective cytotoxicity against Laryngeal Cancer, Breast Cancer, and Neuroblastoma cell lines.

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Pubmed Data : Phytother Res. 2006 Jun;20(6):515-7. PMID: 16619339

Article Published Date : Jun 01, 2006

Study Type : In Vitro Study

Additional Links

Substances : Noni : CK(85) : AC(43)

Diseases : Breast Cancer : CK(2051) : AC(566), Laryngeal Cancer : CK(22) : AC(4), Neuroblastoma : CK(52) : AC(31)

Pharmacological Actions : Antiproliferative : CK(969) : AC(725)

Additional Keywords : Plant Extracts : CK(3401) : AC(1158), Selective Cytotoxicity : CK(42) : AC(37)

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