Superiority of Natural Substances versus Drugs

Superiority of Natural Substances versus Drugs

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Artemisia princeps is superior to the drug rosiglitazone in improving lipid dysregulation and fatty liver in obese diabetic mice.

Pubmed Data : J Med Food. 2009 Dec;12(6):1238-44. PMID: 20041776
Article Published Date : Dec 01, 2009
Study Type : Animal Study
Additional Links
Substances : Artemisia princeps : CK(2) : AC(1)
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Obesity : CK(1849) : AC(275)
Pharmacological Actions : Anti-Adipogenic : CK(87) : AC(44), Lipolytic : CK(44) : AC(15)
Additional Keywords : Drug: Rosiglitazone : CK(17) : AC(5), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Artesunate, a novel derivative of artemisin, has in vitro and in vivo anticancer activity against pancreatic cancer. It exhibits selective cytotoxicity and has in vivo antitumor activity similar to that of gemcitabine.

Pubmed Data : Cancer Chemother Pharmacol. 2010 Apr;65(5):895-902. Epub 2009 Aug 19. PMID: 19690861
Article Published Date : Apr 01, 2010
Study Type : Animal Study
Additional Links
Substances : Artemisinin : CK(59) : AC(13)
Diseases : Pancreatic Cancer : CK(530) : AC(168)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Apoptotic : CK(1489) : AC(1114)
Additional Keywords : Drug: Gemcitabine : CK(36) : AC(13), Selective Cytotoxicity : CK(58) : AC(41), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Black cohosh (Cimicfuga racemosa) has anti-osteoporotic effects in castrated male rats, without profoundly effecting prostate.

Pubmed Data : Maturitas. 2005 Jun 16;51(2):177-86. PMID: 15917159
Article Published Date : Jun 16, 2005
Study Type : Animal Study
Additional Links
Substances : Black Cohosh : CK(37) : AC(15)
Diseases : Osteoporosis: Male : CK(15) : AC(8)
Additional Keywords : Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Black cohosh is an effective alternative to estradiol-17beta due to its selective estrogen receptor modulator activity.

Pubmed Data : Eur J Endocrinol. 2003 Oct;149(4):351-62. PMID: 14514351
Article Published Date : Oct 01, 2003
Study Type : Animal Study
Additional Links
Substances : Black Cohosh : CK(37) : AC(15)
Diseases : Estrogen Deficiency : CK(57) : AC(19)
Pharmacological Actions : Selective Estrogen Receptor Modulators : CK(10) : AC(6)
Additional Keywords : Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Black Cohosh may be an ideal Selective Estrogen Receptor Modulator (SERM) alternative to hormone replacement therapy.

Pubmed Data : Maturitas. 2008 Sep-Oct;61(1-2):159-70. PMID: 19434888
Article Published Date : Sep 01, 2008
Study Type : Animal Study
Additional Links
Substances : Black Cohosh : CK(37) : AC(15)
Diseases : Estrogen Deficiency : CK(57) : AC(19)
Additional Keywords : Selective Estrogen Receptor Modulator (SERM) : CK(2) : AC(1), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Cascara sagrada does not contribute to carcinogenesis in a rat model, as does the stimulant laxative drug bisacodyl (Dulcolax).

Pubmed Data : Life Sci. 2001 Sep 7;69(16):1871-7. PMID: 11693267
Article Published Date : Sep 07, 2001
Study Type : Animal Study
Additional Links
Substances : Cascara sagrada : CK(2) : AC(1)
Diseases : Constipation : CK(316) : AC(36)
Pharmacological Actions : Laxative : CK(12) : AC(3)
Additional Keywords : Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Chamomile is superior to corticosteroids in the healing of ulcers.

Pubmed Data : Phytother Res. 2008 Sep 19. PMID: 18803230
Article Published Date : Sep 19, 2008
Study Type : Animal Study
Additional Links
Substances : Chamomile : CK(95) : AC(18)
Diseases : Wound Healing: Delayed : CK(38) : AC(19)
Additional Keywords : Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Cinnamaldehyde and berberine have greater anti-diabetic efficacy than metformin.

Pubmed Data : Chin Med J (Engl). 2008 Nov 5;121(21):2124-8. PMID: 19080170
Article Published Date : Nov 05, 2008
Study Type : Animal Study
Additional Links
Substances : Berberine : CK(156) : AC(75), Cinnamaldehyde : CK(170) : AC(17), Cinnamon : CK(135) : AC(61)
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341)
Additional Keywords : Drug: Metformin : CK(195) : AC(23), Metformin Alternatives : CK(19) : AC(6), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Cumin seeds improves blood lipid profiles, blood sugar and glycation in diabetic rats more effectively than glibenclamide.

Pubmed Data : Pharmacol Res. 2002 Sep;46(3):251-5. PMID: 12220968
Article Published Date : Sep 01, 2002
Study Type : Animal Study
Additional Links
Substances : Cumin : CK(32) : AC(21)
Diseases : Diabetes: Lipids/Cholesterol : CK(14) : AC(3), Diabetes Mellitus: Type 1 : CK(1107) : AC(218)
Additional Keywords : Alloxan-Induced Diabetes : CK(2) : AC(1), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Curcumin has a similar effect to hydrocortisone in preventing bleomycin-induced pulmonary fibrosis.

Pubmed Data : J Ethnopharmacol. 2007 Jun 13;112(2):292-9. Epub 2007 Mar 13. PMID: 17434272
Article Published Date : Jun 13, 2007
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Chemotherapy-Induced Toxicity: Bleomycin : CK(52) : AC(21), Pulmonary Fibrosis : CK(135) : AC(46)
Additional Keywords : Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Curcumin is more effective than prednisone at suppressing bleomycin-induced pulmonary fibrosis in rats.

Pubmed Data : Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2008 May;26(5):257-61. PMID: 18727865
Article Published Date : May 01, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Chemotherapy-Induced Toxicity: Bleomycin : CK(52) : AC(21), Pulmonary Fibrosis : CK(135) : AC(46)
Pharmacological Actions : Transforming growth factor beta (TGF-β) inhibitor : CK(32) : AC(9)
Additional Keywords : Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Curcumin is superior to drug therapies for preventing scopolamine-induced memory impairment.

Pubmed Data : Fitoterapia. 2011 Jan 26. Epub 2011 Jan 26. PMID: 21277954
Article Published Date : Jan 26, 2011
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Memory Disorders: Drug-Induced : CK(77) : AC(12)
Additional Keywords : Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Docusate sodium exhibits ototoxic properties and is inferior to water for ear wax removal.

Pubmed Data : Otolaryngol Head Neck Surg. 2011 Nov 18. Epub 2011 Nov 18. PMID: 22101097
Article Published Date : Nov 18, 2011
Study Type : Animal Study
Additional Links
Diseases : Ear Wax : CK(2) : AC(1)
Additional Keywords : Superiority of Natural Substances versus Drugs : CK(826) : AC(164)
Problem Substances : Docusate Sodium : CK(2) : AC(1)
Adverse Pharmacological Actions : Ototoxic : CK(2) : AC(1)

Earthworm paste has antioxidant and antiulcer properties superior to the drug ranitidine.

Pubmed Data : Eur Rev Med Pharmacol Sci. 2007 Jan-Feb;11(1):9-15. PMID: 17405344
Article Published Date : Jan 01, 2007
Study Type : Animal Study
Additional Links
Substances : Earthworms : CK(6) : AC(3)
Diseases : Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57), Antioxidants : CK(3653) : AC(1318)
Additional Keywords : Drug: Ranitidine : CK(4) : AC(2), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Earthworm paste has gastroprotective properties and is superior to the drug ranitidine in preventing experimentally induced gastric ulcer.

Pubmed Data : Eur Rev Med Pharmacol Sci. 2010 Mar;14(3):171-6. PMID: 20391954
Article Published Date : Mar 01, 2010
Study Type : Animal Study
Additional Links
Substances : Earthworms : CK(6) : AC(3)
Diseases : Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57), Gastroprotective : CK(62) : AC(31)
Additional Keywords : Science Confirms Tradition : CK(72) : AC(49), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Echinacea can stimulate immune system more than levamisole and has better prophylactic effect on incidence of phenytoin-induced cleft palate.

Pubmed Data : Regul Toxicol Pharmacol. 2006 Dec;46(3):163-6. Epub 2006 Aug 4. PMID: 16889880
Article Published Date : Dec 01, 2006
Study Type : Animal Study
Additional Links
Substances : Echinacea : CK(469) : AC(88)
Diseases : Birth Defects : CK(196) : AC(37), Cleft Lip : CK(2) : AC(1), Immune Disorders: Low Immune Function : CK(488) : AC(115)
Pharmacological Actions : Immunomodulatory : CK(536) : AC(142)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Extract of Lycopus europaeus (Gypsywort) is comparable to the beta-blocker atenolol in reducing cardiac signs associated with hyperthyroidism in rats.

Pubmed Data : Toxicol Sci. 2002 Nov;70(1):40-5. PMID: 16150466
Article Published Date : Nov 01, 2002
Study Type : Animal Study
Additional Links
Substances : Gypsywort : CK(22) : AC(3)
Diseases : Hyperthyroidism : CK(189) : AC(33)
Additional Keywords : Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Garlic is better at lowering glucose, and improving other blood markers, than glibenclamide.

Pubmed Data : Phytomedicine. 2006 Nov;13(9-10):624-9. Epub 2005 Nov 2. PMID: 17085291
Article Published Date : Nov 01, 2006
Study Type : Animal Study
Additional Links
Substances : Garlic : CK(485) : AC(160)
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341)
Additional Keywords : Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Genistein is superior to alendronate (Fosamax) in reducing glucocorticoid-induced osteoporosis and improves bone strength in rats

Pubmed Data : Ann N Y Acad Sci. 2007 Jan;1095:412-7. PMID: 19302595
Article Published Date : Jan 01, 2007
Study Type : Animal Study
Additional Links
Substances : Genistein : CK(450) : AC(174)
Diseases : Corticosteroid-Induced Toxicity : CK(78) : AC(17), Osteoporosis: Steroid-Induced : CK(28) : AC(6), Steroid-Induced Toxicity : CK(24) : AC(9)
Additional Keywords : Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Genistein is superior to the bone drugs alendronate, raloxifene and estradiol in osteoporotic, ovariectomized rats.

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Br J Pharmacol. 2008 Nov;155(6):896-905. Epub 2008 Aug 11. PMID: 18695641
Article Published Date : Nov 01, 2008
Study Type : Animal Study
Additional Links
Substances : Genistein : CK(450) : AC(174)
Diseases : Bone Fractures : CK(1610) : AC(69), Osteopenia : CK(207) : AC(41), Osteoporosis : CK(1171) : AC(205)
Additional Keywords : Ovariectomy-Induced Changes : CK(52) : AC(22), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Geum japonicum, Syzygium aromaticum (Clove), and Terminalia chebula inhibit Cytomegalovirus infection.

Pubmed Data : Nippon Rinsho. 1998 Jan;56(1):156-60. PMID: 9465682
Article Published Date : Jan 01, 1998
Study Type : Animal Study
Additional Links
Substances : Clove : CK(92) : AC(46), Geum japonicum : CK(11) : AC(8), Sumac : CK(37) : AC(16), Terminalia : CK(20) : AC(13)
Diseases : Cytomegalovirus Infections : CK(85) : AC(33)
Pharmacological Actions : Antiviral Agents : CK(613) : AC(280)
Additional Keywords : Drug: Ganciclovir : CK(14) : AC(4), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Ginger extract is superior to the NSAID drug indomethacin in a rat model of rheumatoid arthritis.

Pubmed Data : Basic Clin Pharmacol Toxicol. 2009 Mar;104(3):262-71. Epub 2009 Jan 20. PMID: 19175367
Article Published Date : Mar 01, 2009
Study Type : Animal Study
Additional Links
Substances : Ginger : CK(310) : AC(89)
Diseases : Arthritis: Rheumatoid : CK(289) : AC(54)
Additional Keywords : Food as Medicine : CK(18) : AC(6), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Grapefruit seed extract is comparable to metformin in positively modulating blood lipid profiles and blood sugar.

Pubmed Data : Nig Q J Hosp Med. 2008 Oct-Dec;18(4):211-5. PMID: 19391322
Article Published Date : Oct 01, 2008
Study Type : Animal Study
Additional Links
Substances : Grapefruit Seed Extract : CK(37) : AC(14)
Diseases : Diabetes Mellitus: Type 1 : CK(1107) : AC(218)
Additional Keywords : Drug: Metformin : CK(195) : AC(23), Metformin Alternatives : CK(19) : AC(6), Natural Substances Versus Drugs : CK(988) : AC(165), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Hawthorn and kiwi fruit extracts are superior to simvastatin in lowering cholesterol in mice fed a high cholesterol diet.

Pubmed Data : Am J Chin Med. 2009;37(5):903-8. PMID: 19885950
Article Published Date : Jan 01, 2009
Study Type : Animal Study
Additional Links
Substances : Hawthorn : CK(81) : AC(13), Kiwifruit : CK(26) : AC(7)
Diseases : Arteriosclerosis : CK(2154) : AC(123), Hyperlipidemia : CK(1211) : AC(109)
Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142), Hypolipidemic : CK(370) : AC(80)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

High dose astaxanthin compares favorably to the drugs captopril and pioglitazone at lowering blood pressure, increasing insulin sensitivity and reducing restraint stress.

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Med Sci. 2011;8(2):126-38. Epub 2011 Feb 9. PMID: 21326955
Article Published Date : Jan 01, 2011
Study Type : Animal Study
Additional Links
Substances : Astaxanthin : CK(353) : AC(117)
Diseases : Hypertension : CK(2783) : AC(271), Insulin Resistance : CK(1034) : AC(221), Stress : CK(434) : AC(60)
Pharmacological Actions : Hypotensive : CK(383) : AC(53), Insulin Sensitizers : CK(167) : AC(36)
Additional Keywords : Drug: Captopril : CK(12) : AC(1), Drug: Pioglitazone : CK(2) : AC(1), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

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