Superiority of Natural Substances versus Drugs

Superiority of Natural Substances versus Drugs

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High dose astaxanthin compares favorably to the drugs captopril and pioglitazone at lowering blood pressure, increasing insulin sensitivity and reducing restraint stress.

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Pubmed Data : Int J Med Sci. 2011;8(2):126-38. Epub 2011 Feb 9. PMID: 21326955
Article Published Date : Jan 01, 2011
Study Type : Animal Study
Additional Links
Substances : Astaxanthin : CK(353) : AC(117)
Diseases : Hypertension : CK(2783) : AC(271), Insulin Resistance : CK(1034) : AC(221), Stress : CK(434) : AC(60)
Pharmacological Actions : Hypotensive : CK(383) : AC(53), Insulin Sensitizers : CK(167) : AC(36)
Additional Keywords : Drug: Captopril : CK(12) : AC(1), Drug: Pioglitazone : CK(2) : AC(1), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Kava compares favorably with diazepam in reducing anxiety in mice.

Pubmed Data : Prog Neuropsychopharmacol Biol Psychiatry. 2002 Jun;26(5):855-60. PMID: 12369257
Article Published Date : Jun 01, 2002
Study Type : Animal Study
Additional Links
Substances : Kava Kava : CK(239) : AC(39)
Diseases : Anxiety Disorders : CK(659) : AC(82)
Pharmacological Actions : Anxiolytic : CK(268) : AC(41)
Additional Keywords : Benzodiazepine Alternatives : CK(26) : AC(4), Plant Extracts : CK(3572) : AC(1216), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Melatonin has neuroprotective properties superior to methyprednisone in experimental spinal cord injury.

Pubmed Data : Surg Neurol. 2005 Oct;64(4):355-61. PMID: 16231427
Article Published Date : Oct 01, 2005
Study Type : Animal Study
Additional Links
Substances : Melatonin : CK(470) : AC(131)
Diseases : Lipid Peroxidation : CK(403) : AC(127), Spinal Cord Injuries : CK(98) : AC(28)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Neuroprotective Agents : CK(962) : AC(480)
Additional Keywords : Cortisone Alternatives : CK(79) : AC(12), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Melatonin is superior to methylprednisolone in experimental spinal cord injury.

Pubmed Data : J Neurosurg. 2000 Jul;93(1 Suppl):77-84. PMID: 10879762
Article Published Date : Jul 01, 2000
Study Type : Animal Study
Additional Links
Substances : Melatonin : CK(470) : AC(131)
Diseases : Spinal Cord Injuries : CK(98) : AC(28)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Neuroprotective Agents : CK(962) : AC(480)
Additional Keywords : Cortisone Alternatives : CK(79) : AC(12), Drug: Methylprednisolone : CK(2) : AC(1), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Melatonin supplementation therapy is more potent and effective in comparison to estrogen replacement therapy due to its single-handed ability to revert all the ovariectomy-induced changes.

Pubmed Data : Climacteric. 2012 Aug ;15(4):382-92. Epub 2011 Dec 20. PMID: 22185471
Article Published Date : Jul 31, 2012
Study Type : Animal Study
Additional Links
Substances : Melatonin : CK(470) : AC(131)
Diseases : Estrogen Deficiency : CK(57) : AC(19), Ovariectomy Associated Adverse Changes : CK(18) : AC(7)
Additional Keywords : Ovariectomy-Induced Changes : CK(52) : AC(22), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Mosla scabra is superior to the drug Ribavirin as an antiviral agent against influenza due to its greater safety.

Pubmed Data : J Ethnopharmacol. 2010 Feb 3;127(2):280-5. Epub 2009 Nov 13. PMID: 19914366
Article Published Date : Feb 03, 2010
Study Type : Animal Study
Additional Links
Substances : Mosla scabra : CK(3) : AC(2)
Diseases : Influenza A : CK(305) : AC(73)
Pharmacological Actions : Interferon-gamma (IFN-gamma) inducer : CK(12) : AC(6), Interleukin-2 upregulation : CK(43) : AC(8), Interleukin-4 upregulation : CK(12) : AC(2), Interleukin-5 upregulation : CK(2) : AC(1), Interleukin-6 Downregulation : CK(470) : AC(135)
Additional Keywords : Drug: Ribavirin : CK(2) : AC(1), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Olive leaf extract is superior to the drug glibenclamide in significantly reversing the symptoms of diabetes in type 2 diabetic rats.

Pubmed Data : Br J Nutr. 2007 Oct;98(4):720-6. Epub 2007 Aug 1. PMID: 18844257
Article Published Date : Oct 01, 2007
Study Type : Animal Study
Additional Links
Substances : Olive leaf extract : CK(132) : AC(26)
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341)
Additional Keywords : Glibenclamide Alternatives : CK(12) : AC(2), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Pineapple bromelain has anti-tumor properties superior to the chemo-agent 5-fluorouracil.

Pubmed Data : Planta Med. 2007 Oct;73(13):1377-83. Epub 2007 Sep 24. PMID: 17893836
Article Published Date : Oct 01, 2007
Study Type : Animal Study
Additional Links
Substances : Bromelain : CK(109) : AC(34), Pineapple : CK(141) : AC(39)
Diseases : Cancer Metastasis : CK(272) : AC(135), Lung Cancer : CK(496) : AC(198)
Pharmacological Actions : Anti-metastatic : CK(192) : AC(115)
Additional Keywords : Drug: 5-flourouracil : CK(88) : AC(22), Food as Medicine : CK(18) : AC(6), Hall of Fame : CK(35) : AC(5), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Policosanol against neointima formation in this experimental model was slightly better than that of lovastatin.

Pubmed Data : Science. 2009 Jul 10;325(5937):201-4. PMID: 11207063
Article Published Date : Jul 10, 2009
Study Type : Animal Study
Additional Links
Substances : Policosanol : CK(184) : AC(22)
Diseases : Arteriosclerosis : CK(2154) : AC(123), Intima Media Thickening : CK(1878) : AC(41)
Additional Keywords : Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Red sage contains a compound salvianolic acid B which compares favorably to benazepril in the treatment of chronic myocardial infarction in rats.

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2008 Sep;378(3):311-22. Epub 2008 May 24. PMID: 18500511
Article Published Date : Sep 01, 2008
Study Type : Animal Study
Additional Links
Substances : Red Sage : CK(134) : AC(37)
Diseases : Myocardial Infarction : CK(2632) : AC(117)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Vascular Endothelial Growth Factor A Inhibitor : CK(102) : AC(58)
Additional Keywords : Drug: Benazepril : CK(4) : AC(2), Natural Substance Synergy : CK(144) : AC(81), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Red sage contains a compound salvianolic acid B which compares favorably to benazepril in the treatment of chronic myocardial infarction in rats. - Article 2.

Pubmed Data : Pharmacol Rep. 2008 May-Jun;60(3):369-81. PMID: 18622062
Article Published Date : May 01, 2008
Study Type : Animal Study
Additional Links
Substances : Red Sage : CK(134) : AC(37)
Diseases : Myocardial Infarction : CK(2632) : AC(117)
Pharmacological Actions : Antihypertensive Agents : CK(196) : AC(38), Vascular Endothelial Growth Factor Regulator : CK(28) : AC(12)
Additional Keywords : Drug: Benazepril : CK(4) : AC(2), Natural Substance Synergy : CK(144) : AC(81), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Red seaweed was more effective than tamoxifen in suppressing tumor growth by 27% with little toxicity to the liver and kidneys.

Pubmed Data : Nutr Cancer. 2013 Feb ;65(2):255-62. PMID: 23441613
Article Published Date : Jan 31, 2013
Study Type : Animal Study
Additional Links
Diseases : Breast Cancer : CK(2354) : AC(621)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antioxidants : CK(3653) : AC(1318), Antiproliferative : CK(1052) : AC(775), apoptosis
Additional Keywords : Enzyme Modulating Properties, Natural Substances Versus Drugs : CK(988) : AC(165), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Red Yeast Rice is effective (more than lovastatin) in lowering serum lipids, liver cholesterol levels and inhibiting hepatic steatosis.

Pubmed Data : Adv Exp Med Biol. 1996;403:607-13. PMID: 17974097
Article Published Date : Jan 01, 1996
Study Type : Animal Study
Additional Links
Substances : Red Yeast Rice : CK(164) : AC(25)
Diseases : Hepatic Steatosis : CK(102) : AC(21)
Additional Keywords : Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Resveratrol exhibits superior efficacy versus methylprednisolone, and enhances efficacy in combination, for recovery after experimental spinal cord injury.

Pubmed Data : Acta Pharmacol Sin. 2006 Oct;27(10):1317-25. PMID: 17007738
Article Published Date : Oct 01, 2006
Study Type : Animal Study
Additional Links
Substances : Resveratrol : CK(977) : AC(590)
Diseases : Spinal Cord Injuries : CK(98) : AC(28)
Pharmacological Actions : Neuroprotective Agents : CK(962) : AC(480)
Additional Keywords : Drug-Plant-Vitamin Synergies : CK(1011) : AC(268), Stilbenes : CK(402) : AC(242), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Saw Palmetto (Serenoa repens) is more efficacious than Finasteride in inhibiting prostate enlargement.

Pubmed Data : Prostate. 2000 Apr 1;43(1):49-58.PMID:10725865
Article Published Date : Apr 01, 2000
Study Type : Animal Study
Additional Links
Substances : Saw Palmetto : CK(82) : AC(17)
Diseases : Prostatic Hyperplasia: Benign : CK(202) : AC(46)
Additional Keywords : Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

St. John's wort extract is twice as effective as ibuprofen as an analgesic in an animal model of pain.

Pubmed Data : Pak J Pharm Sci. 2004 Jul;17(2):13-9. PMID: 16414593
Article Published Date : Jul 01, 2004
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort : CK(186) : AC(46)
Diseases : Pain : CK(616) : AC(91)
Pharmacological Actions : Analgesics : CK(372) : AC(78)
Additional Keywords : Ibuprofen Alternatives : CK(37) : AC(12), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Stevia has anti-diabetic properties and compares favorably with the drug glibenclamide but without the adverse effects.

Pubmed Data : J Pharm Bioallied Sci. 2011 Apr ;3(2):242-8. PMID: 21687353
Article Published Date : Apr 01, 2011
Study Type : Animal Study
Additional Links
Substances : Stevia : CK(74) : AC(19)
Diseases : Diabetes Mellitus: Type 1 : CK(1107) : AC(218)
Pharmacological Actions : Hypoglycemic Agents : CK(563) : AC(156)
Additional Keywords : Beta Cell Regeneration : CK(60) : AC(24), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)
Problem Substances : Glibenclamide : CK(122) : AC(3)
Adverse Pharmacological Actions : Hypoglycemic : CK(12) : AC(2)

Tanshinone IIA, a compound found within Red Sage, has potential anti-cancer activity that is stronger than tamoxifen in both ER-positive and ER-negative breast cancers.

Pubmed Data : Int J Mol Med. 2009 Dec;24(6):773-80. PMID: 19885617
Article Published Date : Dec 01, 2009
Study Type : Transgenic Animal Study
Additional Links
Substances : Red Sage : CK(134) : AC(37)
Diseases : Breast Cancer : CK(2354) : AC(621)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114)
Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

The anti-arthritic effect of ursolic acid is comparable to ibuprofen in an animal model of arthritis, without causing gastric leasions.

Pubmed Data : J Pharm Pharmacol. 2008 Oct;60(10):1347-54. PMID: 18812028
Article Published Date : Oct 01, 2008
Study Type : Animal Study
Additional Links
Substances : Ursolic Acid : CK(18) : AC(12)
Diseases : Arthritis : CK(1430) : AC(218)
Pharmacological Actions : Analgesics : CK(372) : AC(78), Anti-Inflammatory Agents : CK(1230) : AC(433)
Additional Keywords : Ibuprofen Alternatives : CK(37) : AC(12), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

The Brazilian plant known as Cambuca (Plinia edulis) is non-toxic and more effective than the drug lansoprazole in preventing experimentally induced ulcers in rats.

Pubmed Data : J Ethnopharmacol. 2008 Aug 13;118(3):527-9. Epub 2008 May 15. PMID: 18583075
Article Published Date : Aug 13, 2008
Study Type : Animal Study
Additional Links
Substances : Cambucá : CK(2) : AC(1)
Diseases : Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57)
Additional Keywords : Brazilian Traditional Medicine : CK(8) : AC(4), Prevacid (Lansoprazole) Alternatives : CK(6) : AC(3), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

The Chinese medicine DSQRL is superior to prednisone in treating experimental pulmonary fibrosis.

Pubmed Data : J Ethnopharmacol. 2008 Mar 5;116(2):318-24. Epub 2007 Dec 4. PMID: 18191351
Article Published Date : Mar 05, 2008
Study Type : Animal Study
Additional Links
Substances : Chinese Herbal Formula: Decoction for Strengthening Qi and Replenishing Lung (DSQRL) : CK(2) : AC(1)
Diseases : Pulmonary Fibrosis : CK(135) : AC(46)
Additional Keywords : Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

The homeopathic dilution known as plumbum metallicum 30c is superior to calcitonin in regenerating bone in an animal study.

Pubmed Data : Homeopathy. 2009 Apr;98(2):92-6. PMID: 19358962
Article Published Date : Apr 01, 2009
Study Type : Animal Study
Additional Links
Substances : Plumbum metallicum : CK(2) : AC(1)
Diseases : Bone Fractures : CK(1610) : AC(69)
Therapeutic Actions : Homeopathic Treatment : CK(638) : AC(70)
Additional Keywords : Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Thyme, yarrow and propolis are significantly more effective than glucantime in the treatment of Leishmaniasis in mice.

Pubmed Data : Biosci Biotechnol Biochem. 2008 Jan;72(1):94-100. Epub 2008 Jan 7. PMID: 19248657
Article Published Date : Jan 01, 2008
Study Type : Animal Study
Additional Links
Substances : Bee Propolis : CK(220) : AC(83), Thyme : CK(39) : AC(22), Yarrow : CK(7) : AC(7)
Diseases : Leishmaniasis : CK(20) : AC(17)
Pharmacological Actions : Leishmanicidal : CK(14) : AC(12)
Additional Keywords : Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Thymoquinone, the main constituent of Nigella sativa (black cumin) is superior to the drug fluticasone in an animal model of asthma.

Pubmed Data : J Ethnopharmacol. 2009 Oct 29;126(1):102-7. Epub 2009 Aug 8. PMID: 19711253
Article Published Date : Oct 29, 2009
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed) : CK(133) : AC(34)
Diseases : Asthma : CK(918) : AC(134)
Pharmacological Actions : Anticholinergic : CK(4) : AC(2), Bronchodilator Agents : CK(56) : AC(12), Histamine Antagonists : CK(46) : AC(18)
Additional Keywords : Cortisone Alternatives : CK(79) : AC(12), Drug: Fluticasone : CK(22) : AC(3), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Vitamin E, acetyl-l-carnitine and α-lipoic acid are superior to the drug donepezil (Aricept) at normalizing biomarkers associated with Alzheimer's disease in an animal model.

Pubmed Data : Exp Toxicol Pathol. 2010 Dec 23. Epub 2010 Dec 23. PMID: 21183322
Article Published Date : Dec 23, 2010
Study Type : Animal Study
Additional Links
Substances : Acetyl-l-carnitine : CK(672) : AC(38), Alpha-Lipoic Acid : CK(384) : AC(82), Vitamin E : CK(1285) : AC(221)
Diseases : Alzheimer's Disease : CK(826) : AC(160)
Additional Keywords : Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

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