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Abstract Title:

Antitumor activity of the tea polyphenol epigallocatechin-3-gallate encapsulated in targeted vesicles after intravenous administration.

Abstract Source:

Nanomedicine (Lond). 2013 Feb ;8(2):181-92. Epub 2012 Aug 14. PMID: 22891867

Abstract Author(s):

Fanny Lemarié, Chun Wai Chang, David R Blatchford, Rumelo Amor, Greg Norris, Laurence Tetley, Gail McConnell, Christine Dufès

Article Affiliation:

Fanny Lemarié

Abstract:

AIM: The therapeutic potential of epigallocatechin-3-gallate (EGCG), a green tea polyphenol with anticancer properties, is limited by its inability to specifically reach tumors following intravenous administration. The purpose of this study was to determine whether a tumor-targeted vesicular formulation of EGCG would suppress the growth of A431 epidermoid carcinoma and B16-F10 melanoma in vitro and in vivo.

MATERIALS & METHODS: Transferrin-bearing vesicles encapsulating EGCG were administered intravenously to mice bearing subcutaneous A431 and B16-F10 tumors.

RESULTS: The intravenous administration of EGCG encapsulated in transferrin-bearing vesicles resulted in tumor suppression in 40% of A431 and B16-F10 tumors. Animal survival was improved by more than 20 days compared with controls.

CONCLUSION: Encapsulation of EGCG in transferrin-bearing vesicles is a promising therapeutic strategy.

Study Type : Animal Study, In Vitro Study

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