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Acid Blockers
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Additional Topics Details for this Page
Article Count
- 16
Cumulative Knowledge
- 40
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The Following are Sub-Topics of Acid Blockers
Proton Pump Inhibitor
Histamine H2 Antagonists
What is Cumulative Knowledge?
Cumulative Knowledge
is determined by ascribing a numerical value to the various study types weighted in descending order as follows: (1) Meta-Analysis; (2) Human Study; (3) Human: Case Study; (4) Animal: Transgenic; (5) Animal; (6) In Vitro; (7) Review; and (8) Commentary.
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Quick Summary: Current access displays 2 out of 21 associated Substances
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Cumulative Knowledge
Article Count
Focus Articles
Melatonin
11
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View the Evidence: Pharmacological Actions
A dietary supplement containing melatonin, l-tryptophan, vitamin B6, folic acid, vitamin B12, methionine and betaine, is superior to omeprazole in treating GERD.
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2006 Oct;41(3):195-200. PMID:
16948779
Article Published Date
: Oct 01, 2006
Study Type
: Human Study
Additional Links
Substances
:
Betaine : CK(16) : AC(4)
,
Folic Acid : CK(542) : AC(77)
,
Melatonin : CK(470) : AC(131)
,
Methionine : CK(52) : AC(12)
,
Tryptophan : CK(322) : AC(30)
,
Vitamin B-12 : CK(752) : AC(94)
,
Vitamin B-6 : CK(412) : AC(48)
Diseases
:
Gastroesophageal Reflux : CK(278) : AC(41)
Pharmacological Actions
:
Proton Pump Inhibitor : CK(36) : AC(13)
Additional Keywords
:
Superiority of Natural Substances versus Drugs : CK(826) : AC(164)
Neem bark has therapeutic potential for controlling gastric hypersecretion and gastroesophageal and gastroduodenal uclcers.
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2004 Oct 29;75(24):2867-78. PMID:
15454339
Article Published Date
: Oct 29, 2004
Study Type
: Human Study
Additional Links
Substances
:
Neem : CK(88) : AC(19)
Diseases
:
Gastroduodenal Ulcer : CK(82) : AC(9)
,
Gastroesophageal Reflux : CK(278) : AC(41)
,
Peptic Ulcer : CK(454) : AC(110)
Pharmacological Actions
:
Proton Pump Inhibitor : CK(36) : AC(13)
Celery extract significantly protects the gastric mucosa and suppresses the basal gastric secretion in rats, possibly through its antioxidant potential.
Click here to read the entire abstract
Pubmed Data
: Pharm Biol. 2010 Jul ;48(7):786-93. PMID:
20645778
Article Published Date
: Jul 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Celery : CK(30) : AC(12)
Diseases
:
Acid Reflux : CK(288) : AC(42)
,
Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions
:
Acid Blockers : CK(40) : AC(16)
,
Anti-Ulcer Agents : CK(162) : AC(57)
,
Malondialdehyde Down-regulation : CK(76) : AC(21)
Additional Keywords
:
Plant Extracts : CK(3572) : AC(1216)
Curcumin compares favorably with bisdemethoxycurcumin in a gastric ulcer model system.
Click here to read the entire abstract
Pubmed Data
: Phytomedicine. 2009 Apr;16(4):342-51. Epub 2009 Feb 1. PMID:
19188055
Article Published Date
: Apr 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Bisdemethoxycurcumin : CK(5) : AC(2)
,
Curcumin : CK(2910) : AC(1482)
Diseases
:
Gastric Ulcer : CK(246) : AC(91)
,
Lipopolysaccharide-Induced Toxicity : CK(227) : AC(128)
Pharmacological Actions
:
Anti-Ulcer Agents : CK(162) : AC(57)
,
Proton Pump Inhibitor : CK(36) : AC(13)
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)
Ellagic acid inhibits the gastric proton pumps, reducing acid secretion and the occurence of stress-induced gastric lesions.
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2008 Jun;52(6):692-700. PMID:
1663631
Article Published Date
: Jun 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Ellagic Acid : CK(77) : AC(40)
Diseases
:
Acid Reflux : CK(288) : AC(42)
,
Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions
:
Anti-Ulcer Agents : CK(162) : AC(57)
,
Proton Pump Inhibitor : CK(36) : AC(13)
Ginger has a gastroprotective effect through its acid blocking and anti-Helico bacter pylori activity.
Click here to read the entire abstract
Pubmed Data
: Evid Based Complement Alternat Med. 2009 Jul 1. PMID:
19570992
Article Published Date
: Jul 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Ginger : CK(310) : AC(89)
Diseases
:
Acid Reflux : CK(288) : AC(42)
,
Gastroesophageal Reflux : CK(278) : AC(41)
,
Helicobacter Pylori Infection : CK(305) : AC(61)
Pharmacological Actions
:
Anti-Bacterial Agents : CK(970) : AC(316)
,
Proton Pump Inhibitor : CK(36) : AC(13)
Additional Keywords
:
Natural Substances Versus Drugs : CK(988) : AC(165)
,
Prevacid (Lansoprazole) Alternatives : CK(6) : AC(3)
Red sage (Salvia miltiorrhiza) contains a compound which inhibits the gastric proton pump, reducing acid production and lesions.
Click here to read the entire abstract
Pubmed Data
: Planta Med. 1990 Aug;56(4):360-3. PMID:
2173008
Article Published Date
: Aug 01, 1990
Study Type
: Animal Study
Additional Links
Substances
:
Red Sage : CK(134) : AC(37)
Diseases
:
Acid Reflux : CK(288) : AC(42)
,
Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions
:
Anti-Ulcer Agents : CK(162) : AC(57)
,
Proton Pump Inhibitor : CK(36) : AC(13)
Tabebuia tree bark extract has a protective effect against gastric lesions.
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2008 Aug 13;118(3):455-9. Epub 2008 May 18. PMID:
18579323
Article Published Date
: Aug 13, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Tabebuia : CK(10) : AC(9)
Diseases
:
Duodenal Ulcer : CK(89) : AC(26)
,
Gastric Ulcer : CK(246) : AC(91)
,
Peptic Ulcer : CK(454) : AC(110)
Pharmacological Actions
:
Anti-Ulcer Agents : CK(162) : AC(57)
,
Proton Pump Inhibitor : CK(36) : AC(13)
Catechins such as EGCG (found in green tea) act as proton pump inhibitors.
Click here to read the entire abstract
Pubmed Data
: J Pharm Pharmacol. 1992 Nov;44(11):926-8. PMID:
1361539
Article Published Date
: Nov 01, 1992
Study Type
: In Vitro Study
Additional Links
Substances
:
Catechin : CK(403) : AC(130)
,
EGCG (Epigallocatechin gallate) : CK(859) : AC(109)
Diseases
:
Acid Reflux : CK(288) : AC(42)
Pharmacological Actions
:
Proton Pump Inhibitor : CK(36) : AC(13)
Curcumin has profound immunosuppressive effects of potential value in organ transplantation.
Click here to read the entire abstract
Pubmed Data
: J Surg Res. 2004 Oct;121(2):171-7. PMID:
15501456
Article Published Date
: Oct 01, 2004
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin : CK(2910) : AC(1482)
Diseases
:
Organ Transplantation : CK(50) : AC(17)
Pharmacological Actions
:
Antiproliferative : CK(1052) : AC(775)
,
Histamine H2 Antagonists : CK(2) : AC(2)
,
Immunosuppressive Agents : CK(26) : AC(19)
,
NF-kappaB Inhibitor : CK(595) : AC(401)
Curcumin protects against gastric ulcers by blocking H2 histamine receptors.
Click here to read the entire abstract
Pubmed Data
: Biol Pharm Bull. 2005 Dec;28(12):2220-4. PMID:
16327153
Article Published Date
: Dec 01, 2005
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin : CK(2910) : AC(1482)
Diseases
:
Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions
:
Anti-Ulcer Agents : CK(162) : AC(57)
,
Histamine H2 Antagonists : CK(2) : AC(2)
Additional Keywords
:
Plant Extracts : CK(3572) : AC(1216)
Melatonin may provide a safe and effective alternative to proton-pump inhibitors in the treatment of gastroesophageal reflux disease.
Click here to read the entire abstract
Pubmed Data
: Altern Ther Health Med. 2008 Jul-Aug;14(4):54-8. PMID:
18616070
Article Published Date
: Jul 01, 2008
Study Type
: Review
Additional Links
Substances
:
Melatonin : CK(470) : AC(131)
Diseases
:
Gastroesophageal Reflux : CK(278) : AC(41)
Pharmacological Actions
:
Proton Pump Inhibitor : CK(36) : AC(13)
Additional Keywords
:
Superiority of Natural Substances versus Drugs : CK(826) : AC(164)
Oleic acid may be a potent inhibitor of the proton pumps.
Click here to read the entire abstract
Pubmed Data
: Res Commun Chem Pathol Pharmacol. 1991 Mar;71(3):337-50. PMID:
1646470
Article Published Date
: Mar 01, 1991
Study Type
: In Vitro Study
Additional Links
Substances
:
Oleic acid : CK(18) : AC(6)
Diseases
:
Acid Reflux : CK(288) : AC(42)
,
Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions
:
Proton Pump Inhibitor : CK(36) : AC(13)
Quercetin inhibits gastric proton pumps.
Click here to read the entire abstract
Pubmed Data
: J Enzyme Inhib. 1992;5(4):293-8. PMID:
1285250
Article Published Date
: Jan 01, 1992
Study Type
: In Vitro Study
Additional Links
Substances
:
Quercetin : CK(318) : AC(136)
Diseases
:
Acid Reflux : CK(288) : AC(42)
Pharmacological Actions
:
Proton Pump Inhibitor : CK(36) : AC(13)
Sage has gastroprotective compounds which exhibit proton and potassium pump inhibitory activity.
Click here to read the entire abstract
Pubmed Data
: Fitoterapia. 2009 Oct;80(7):421-6. Epub 2009 May 28. PMID:
19481590
Article Published Date
: Oct 01, 2009
Study Type
: In Vitro Study
Additional Links
Substances
:
Sage : CK(91) : AC(18)
Diseases
:
Alcohol Toxicity : CK(212) : AC(85)
,
Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions
:
Proton Pump Inhibitor : CK(36) : AC(13)
Additional Keywords
:
Plant Extracts : CK(3572) : AC(1216)
Tannic acid inhibits the gastric proton pump, indicating its anti-secretory and anti-ulcerogenic properties.
Click here to read the entire abstract
Pubmed Data
: J Nat Prod. 1992 Apr;55(4):513-6. PMID:
1324983
Article Published Date
: Apr 01, 1992
Study Type
: In Vitro Study
Additional Links
Substances
:
Tannic Acid : CK(20) : AC(16)
Diseases
:
Acid Reflux : CK(288) : AC(42)
,
Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions
:
Anti-Ulcer Agents : CK(162) : AC(57)
,
Proton Pump Inhibitor : CK(36) : AC(13)
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