Anti-Apoptotic

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View the Evidence: Pharmacological Actions

Cocoa procyanidins attenuate lipid peroxidation associated neuronal cell death in a manner relevant to Alzheimer's disease.

Pubmed Data : Free Radic Biol Med. 2009 May 15;46(10):1319-27. Epub 2009 Feb 25. PMID: 19248828
Article Published Date : May 15, 2009
Study Type : Human Study
Additional Links
Substances : Catechin : CK(403) : AC(130)
Diseases : Alzheimer's Disease : CK(886) : AC(160), Neurodegenerative Diseases : CK(1743) : AC(420), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Anti-Apoptotic : CK(59) : AC(39), Antioxidants : CK(3653) : AC(1318)
Additional Keywords : Proanthocyanidins : CK(159) : AC(46)

"Apoptosis inhibition of capsaicin on myocardial ischemia-reperfusion injury in rats"

Pubmed Data : Sichuan Da Xue Xue Bao Yi Xue Ban. 2011 Mar ;42(2):218-21. PMID: 21500557
Article Published Date : Feb 28, 2011
Study Type : Animal Study
Additional Links
Substances : Capsaicin : CK(60) : AC(34)
Diseases : Myocardial Infarction : CK(2632) : AC(117), Myocardial Ischemia : CK(87) : AC(37)
Pharmacological Actions : Anti-Apoptotic : CK(59) : AC(39), Cardioprotective : CK(702) : AC(196)

Astaxanthin ameliorates the redox imbalance in lymphocytes of experimental diabetic rats.

Pubmed Data : Chem Biol Interact. 2010 Aug 5;186(3):306-15. Epub 2010 May 31. PMID: 20513374
Article Published Date : Aug 05, 2010
Study Type : Animal Study
Additional Links
Substances : Astaxanthin : CK(353) : AC(117)
Diseases : Diabetes: Immune Problems : CK(2) : AC(1), Diabetes: Oxidative Stress : CK(65) : AC(18)
Pharmacological Actions : Anti-Apoptotic : CK(59) : AC(39), Antioxidants : CK(3653) : AC(1318), Antiproliferative : CK(1058) : AC(775)

Bamboo has anti-apoptic and neuroprotective effects and may be useful for ischemic injury.

Pubmed Data : J Ethnopharmacol. 2010 Apr 21;128(3):594-9. Epub 2010 Feb 1. PMID: 20117201
Article Published Date : Apr 21, 2010
Study Type : Animal Study
Additional Links
Substances : Bamboo : CK(45) : AC(22)
Diseases : Brain Damage : CK(89) : AC(41), Brain Ischemia : CK(94) : AC(38)
Pharmacological Actions : Anti-Apoptotic : CK(59) : AC(39), Neuroprotective Agents : CK(962) : AC(480)

Curcumin improves outcomes and attenuates focal cerebral ischemic injury.

Pubmed Data : Neurochem Res. 2010 Mar;35(3):374-9. Epub 2009 Sep 23. PMID: 19774461
Article Published Date : Mar 01, 2010
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2923) : AC(1482)
Diseases : Cerebral Ischemia : CK(263) : AC(50), Middle Cerebral Artery Occlusion (MCAO) : CK(592) : AC(24), Oxidative Stress : CK(1945) : AC(710), Stroke: Recovery : CK(68) : AC(9)
Pharmacological Actions : Anti-Apoptotic : CK(59) : AC(39), Antioxidants : CK(3653) : AC(1318), Neuroprotective Agents : CK(962) : AC(480)

Curcumin protects against acetaminophen-induced toxicity.

Pubmed Data : Curr Neurovasc Res. 2012 Jan 16. Epub 2012 Jan 16. PMID: 22272768
Article Published Date : Jan 16, 2012
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2923) : AC(1482)
Diseases : Acetaminophen (Tylenol) Toxicity : CK(100) : AC(26), Chemically-Induced Liver Damage : CK(475) : AC(175)
Pharmacological Actions : Anti-Apoptotic : CK(59) : AC(39), Apoptotic : CK(1535) : AC(1155), Hepatoprotective : CK(557) : AC(272)

Grape seed extract prevents acetaminophen-induced cell death in the mouse liver.

Pubmed Data : Arch Biochem Biophys. 1999 Sep 1;369(1):42-58. PMID: 10462439
Article Published Date : Sep 01, 1999
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract : CK(168) : AC(57)
Diseases : Acetaminophen (Tylenol) Toxicity : CK(100) : AC(26)
Pharmacological Actions : Anti-Apoptotic : CK(59) : AC(39), Antioxidants : CK(3653) : AC(1318)
Additional Keywords : Proanthocyanidins : CK(159) : AC(46)

Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by beta-amyloid protein-(1-40) in rat.

Pubmed Data : Eur J Pharmacol. 2001 Jun 15;421(3):149-56. PMID: 11516430
Article Published Date : Jun 15, 2001
Study Type : Animal Study
Additional Links
Substances : Huperzine : CK(44) : AC(24)
Diseases : Alzheimer's Disease : CK(886) : AC(160), Cognitive Decline/Dysfunction : CK(522) : AC(87), Neurodegenerative Diseases : CK(1743) : AC(420)
Pharmacological Actions : Anti-Apoptotic : CK(59) : AC(39), Neuroprotective Agents : CK(962) : AC(480), Tumor Suppressor Protein p53 Upregulation : CK(163) : AC(105)

Melatonin may delay aging in gastric mucosa tissue by decreasing caspase-3 activity.

Pubmed Data : Aging Clin Exp Res. 2011 Mar 14. Epub 2011 Mar 14. PMID: 21406955
Article Published Date : Mar 14, 2011
Study Type : Animal Study
Additional Links
Substances : Melatonin : CK(470) : AC(131)
Diseases : Aging : CK(1351) : AC(369)
Pharmacological Actions : Anti-Apoptotic : CK(59) : AC(39), Caspase-3 Activation : CK(28) : AC(15)

Pomegranate peel extract protects against ionizing radiation-induced enteritis and leukocyte damage in rats.

Pubmed Data : J Radiat Res (Tokyo). 2009 Jul;50(4):345-53. Epub 2009 May 29. PMID: 19478462
Article Published Date : Jul 01, 2009
Study Type : Animal Study
Additional Links
Substances : Pomegranate : CK(146) : AC(61)
Diseases : Radiation Induced Illness : CK(1018) : AC(249)
Pharmacological Actions : Anti-Apoptotic : CK(59) : AC(39), Radioprotective : CK(458) : AC(183)
Additional Keywords : Plant Extracts : CK(3616) : AC(1226)

Silymarin, a compound found within milk thistle, has a protective effect against Doxorubicin-induced oxidative stress and liver damage.

Pubmed Data : Toxicol Appl Pharmacol. 2010 Feb 5. Epub 2010 Feb 5. PMID: 20144634
Article Published Date : Feb 05, 2010
Study Type : Animal Study
Additional Links
Substances : Milk Thistle : CK(226) : AC(55)
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin : CK(59) : AC(25)
Pharmacological Actions : Anti-Apoptotic : CK(59) : AC(39), Antioxidants : CK(3653) : AC(1318), Hepatoprotective : CK(557) : AC(272)
Additional Keywords : Drug: Doxorubicin : CK(141) : AC(55)

The Kidney tonifying principle in Traditional Chinese Medicine may slow aging.

Pubmed Data : J Med Food. 2007 Dec;10(4):689-93. PMID: 12585100
Article Published Date : Dec 01, 2007
Study Type : Animal Study
Additional Links
Diseases : Aging : CK(1351) : AC(369)
Therapeutic Actions : Traditional Chinese Medicine : CK(72) : AC(7)
Pharmacological Actions : Anti-Apoptotic : CK(59) : AC(39)

Zinc supplementation protects against liver cell death in mice subjected to long-term ethanol exposure.

Pubmed Data : Exp Biol Med (Maywood). 2008 May;233(5):540-8. Epub 2008 Mar 28. PMID: 18375824
Article Published Date : May 01, 2008
Study Type : Animal Study
Additional Links
Substances : Zinc : CK(870) : AC(127)
Diseases : Alcoholic Liver Disease : CK(146) : AC(50), Chemically-Induced Liver Damage : CK(475) : AC(175)
Pharmacological Actions : Anti-Apoptotic : CK(59) : AC(39), Hepatoprotective : CK(557) : AC(272)

A cannabinoid receptor 2 agonist attenuates cisplatin-induced apoptosis in auditory cells.

Pubmed Data : J Neurosci Res. 2007 Mar;85(4):896-905. PMID: 17183590
Article Published Date : Mar 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Cannabis : CK(738) : AC(132)
Diseases : Auditory Diseases : CK(3) : AC(2), Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66)
Pharmacological Actions : Anti-Apoptotic : CK(59) : AC(39)

A polysaccharide from Lion's mane enhances nerve growth and reduces cell death in adrenal cells.

Pubmed Data : Cytotechnology. 2002 Sep ;39(3):155-62. PMID: 19003308
Article Published Date : Sep 01, 2002
Study Type : In Vitro Study
Additional Links
Substances : Lion's Mane (Hericium Erinaceus) : CK(41) : AC(18)
Diseases : Adrenal Gland: Enhanced Apoptosis : CK(1) : AC(1), Adrenal Gland Diseases : CK(3) : AC(2)
Pharmacological Actions : Anti-Apoptotic : CK(59) : AC(39), Neuritogenic : CK(98) : AC(48)

Astaxanthin inhibits oxidative stress and cell death in mouse neural progenitor cells.

Pubmed Data : J Microbiol Biotechnol. 2009 Nov;19(11):1355-63. PMID: 19996687
Article Published Date : Nov 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Astaxanthin : CK(353) : AC(117)
Diseases : Neurotoxicity : CK(37) : AC(15)
Pharmacological Actions : Anti-Apoptotic : CK(59) : AC(39), Enzyme Inhibitors : CK(372) : AC(208), Neuroprotective Agents : CK(962) : AC(480), P38 Mitogen-Activated Protein Kinase Modulator : CK(6) : AC(5)

Astaxanthin protects against beta-amyloid-induced oxidative stress in neuronal cells.

Pubmed Data : Brain Res. 2010 Nov 11;1360:159-67. Epub 2010 Sep 7. PMID: 20828541
Article Published Date : Nov 11, 2010
Study Type : In Vitro Study
Additional Links
Substances : Astaxanthin : CK(353) : AC(117)
Diseases : Alzheimer's Disease : CK(886) : AC(160), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Anti-Apoptotic : CK(59) : AC(39), Neuroprotective Agents : CK(962) : AC(480)

Cadmium may contribute to prostate cancer through inhibiting programmed cell death.

Pubmed Data : Biometals. 2004 Oct;17(5):555-8. PMID: 15688863
Article Published Date : Oct 01, 2004
Study Type : Commentary
Additional Links
Diseases : Cadmium Poisoning : CK(64) : AC(30), Prostate Cancer : CK(998) : AC(288)
Pharmacological Actions : Anti-Apoptotic : CK(59) : AC(39)
Additional Keywords : Diseases that are Linked : CK(2122) : AC(270)

Coconut water extract protects neuronal cells from beta amyloid-induced cell death through antioxidant and antiapoptic funtions.

Pubmed Data : Pharmazie. 2009 Nov;64(11):760-4. PMID: 20099523
Article Published Date : Nov 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Poria cocos : CK(4) : AC(3)
Diseases : Alzheimer's Disease : CK(886) : AC(160), Neurodegenerative Diseases : CK(1743) : AC(420), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Anti-Apoptotic : CK(59) : AC(39), Antioxidants : CK(3653) : AC(1318), Neuroprotective Agents : CK(962) : AC(480)
Additional Keywords : Plant Extracts : CK(3616) : AC(1226)

Curcumin and NAC protect against pesticide-induced cell death in human peripheral blood mononuclear cells.

Pubmed Data : J Biochem Mol Toxicol. 2010 Sep;24(5):286-92. PMID: 20979154
Article Published Date : Sep 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2923) : AC(1482)
Diseases : Pesticide Toxicity : CK(147) : AC(45)
Pharmacological Actions : Anti-Apoptotic : CK(59) : AC(39)

Curcumin exerts anti-apoptotic and anti-catabolic effects on IL-1beta-stimulated articular chondrocytes, indicating is may have therapeutic value in the treatment of osteoarthritis and related osteoarticular disorders.

Pubmed Data : Ann Anat. 2005 Nov;187(5-6):487-97. PMID: 16320828
Article Published Date : Nov 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2923) : AC(1482)
Diseases : Osteoarthritis : CK(615) : AC(91)
Pharmacological Actions : Anti-Apoptotic : CK(59) : AC(39), Enzyme Inhibitors : CK(372) : AC(208), Interleukin-1 beta downregulation : CK(177) : AC(70)

Curcumin protects against cerebral ischemia-induced neuronal cell death.

Pubmed Data : J Neurosci Res. 2005 Oct 1;82(1):138-48. PMID: 16075466
Article Published Date : Oct 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2923) : AC(1482)
Diseases : Brain: Microglial Activation : CK(67) : AC(38), Brain Ischemia : CK(94) : AC(38), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Anti-Apoptotic : CK(59) : AC(39), Neuroprotective Agents : CK(962) : AC(480)
Additional Keywords : Lectins : CK(58) : AC(36)

Curcumin protects against copper injury.

Pubmed Data : Psychiatry Res. 1999 Nov 29;88(3):227-32. PMID: 18082042
Article Published Date : Nov 29, 1999
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2923) : AC(1482)
Diseases : Copper Toxicity : CK(23) : AC(10)
Pharmacological Actions : Anti-Apoptotic : CK(59) : AC(39)

EGCG protects liver cells against ethanol-induced cytotoxicity and programmed cell death.

Pubmed Data : Basic Clin Pharmacol Toxicol. 2007 Mar;100(3):151-6. PMID: 17309517
Article Published Date : Mar 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Catechin : CK(403) : AC(130)
Diseases : Alcohol Toxicity : CK(212) : AC(85), Alcoholic Liver Disease : CK(146) : AC(50)
Pharmacological Actions : Anti-Apoptotic : CK(59) : AC(39), Antioxidants : CK(3653) : AC(1318), Hepatoprotective : CK(557) : AC(272)

Epicatechin and catechin in cocoa inhibit amyloid beta protein induced neuronal cell death.

Pubmed Data : J Agric Food Chem. 2005 Mar 9;53(5):1445-8. PMID: 15740021
Article Published Date : Mar 09, 2005
Study Type : In Vitro Study
Additional Links
Substances : Catechin : CK(403) : AC(130)
Diseases : Alzheimer's Disease : CK(886) : AC(160), Neurodegenerative Diseases : CK(1743) : AC(420)
Pharmacological Actions : Anti-Apoptotic : CK(59) : AC(39), Neuroprotective Agents : CK(962) : AC(480)

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