Anti-Inflammatory Agents

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View the Evidence: Pharmacological Actions

Corticosteroid injections have no intermediate or long-term benefits in treating tendinopathy.

Pubmed Data : Lancet. 2010 Nov 20 ;376(9754):1751-67. Epub 2010 Oct 21. PMID: 20970844
Article Published Date : Nov 20, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Tendinopathy : CK(53) : AC(5)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433)
Problem Substances : Corticosteroid : CK(166) : AC(16)

Three clinical trials show that homeopathic arnica reduces postoperative swelling in patients receiving knee surgery.

Pubmed Data : Complement Ther Med. 2006 Dec;14(4):237-46. Epub 2006 Oct 13. PMID: 17105693
Article Published Date : Dec 01, 2006
Study Type : Meta Analysis
Additional Links
Substances : Arnica : CK(146) : AC(23)
Diseases : Edema : CK(107) : AC(13), Knee Replacement Surgery: Adverse Effects : CK(30) : AC(2), Postoperative Recovery : CK(100) : AC(9)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433)

A Boswellia serrata extract safely reduces pain and improves physical functioning significantly in osteoarthritis patients.

Pubmed Data : Arthritis Res Ther. 2008;10(4):R85. Epub 2008 Jul 30. PMID: 18667054
Article Published Date : Jan 01, 2008
Study Type : Human Study
Additional Links
Substances : Boswellia : CK(122) : AC(31)
Diseases : Osteoarthritis : CK(615) : AC(91)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433)

A combination of nicotinamide 750 mg, zinc 25 mg, copper 1.5 mg, and folic acid 500 microg, marketed as Nicomide, appears to be an effective oral therapy for the treatment of acne vulgaris and rosacea.

Pubmed Data : Cutis. 2006 Jan;77(1 Suppl):17-28. PMID: 16871775
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Substances : Copper : CK(82) : AC(16), Folic Acid : CK(542) : AC(77), Vitamin B-3 (Niacin) : CK(205) : AC(28), Zinc : CK(870) : AC(127)
Diseases : Acne : CK(198) : AC(32), Rosacea : CK(175) : AC(21)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433)

A complex of curcumin and phosphatidylcholine is effective in reducing the symptoms of ostearthritis.

Pubmed Data : Altern Med Rev. 2010 Dec;15(4):337-44. PMID: 21194249
Article Published Date : Dec 01, 2010
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(2923) : AC(1482), Phosphatidylcholine : CK(101) : AC(22)
Diseases : Osteoarthritis : CK(615) : AC(91)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433)

A grape seed extract reduces the inflammatory response and oxidative stress in patients with systemic sclerosis.

Pubmed Data : Free Radic Res. 2002 Aug;36(8):819-25. PMID: 12420739
Article Published Date : Aug 01, 2002
Study Type : Human Study
Additional Links
Substances : Grape Seed Extract : CK(168) : AC(57)
Diseases : Sclerosis: Systemic : CK(82) : AC(9)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Antioxidants : CK(3653) : AC(1318)

Acupuncture has therapeutic value in supporting nerve block treatment for lumbar disc herniation.

Pubmed Data : Zhongguo Zhen Jiu. 2010 Aug;30(8):633-6. PMID: 20942278
Article Published Date : Aug 01, 2010
Study Type : Human Study
Additional Links
Diseases : Herniated Disk : CK(104) : AC(11)
Therapeutic Actions : Acupuncture : CK(1294) : AC(147)
Pharmacological Actions : Analgesics : CK(372) : AC(78), Anti-Inflammatory Agents : CK(1230) : AC(433)
Additional Keywords : Therapeutic Action Synergy with Drugs : CK(20) : AC(2)

Administration of glycyrrhizin resulted in a modest induction of CYP3A that was clinically relevant according to the bioequivalence analysis.

Pubmed Data : Eur J Clin Pharmacol. 2010 Aug ;66(8):805-810. Epub 2010 Apr 15. PMID: 20393696
Article Published Date : Jul 31, 2010
Study Type : Human Study
Additional Links
Substances : Glycyrrhizin : CK(7) : AC(6)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), CYP3A enzyme induction : CK(10) : AC(0)

An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men.

Pubmed Data : Am J Clin Nutr. 2010 Apr;91(4):1044-59. Epub 2010 Feb 24. PMID: 20181810
Article Published Date : Apr 01, 2010
Study Type : Human Study
Additional Links
Substances : Green Tea : CK(930) : AC(294), Omega-3 Fatty Acids : CK(3333) : AC(319), Resveratrol : CK(977) : AC(590), Tomato : CK(271) : AC(47), Vitamin C : CK(1274) : AC(238), Vitamin E : CK(1285) : AC(221)
Diseases : Adiponectin: Low Levels : CK(88) : AC(25), Endothelial Dysfunction : CK(897) : AC(173), Inflammation : CK(1077) : AC(363), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Antioxidants : CK(3653) : AC(1318)

An elemental diet is at least as effective as steroids in inducing remission in mild-moderately active Crohn's disease.

Pubmed Data : Aliment Pharmacol Ther. 1997 Aug;11(4):735-40. PMID: 9305483
Article Published Date : Aug 01, 1997
Study Type : Human Study
Additional Links
Diseases : Intestinal Permeability : CK(224) : AC(53)
Therapeutic Actions : Dietary Modification: Elemental Diet : CK(145) : AC(17)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433)
Additional Keywords : Cortisone Alternatives : CK(79) : AC(12), Therapeutic Action Superior to Drug Therapy : CK(240) : AC(25)

Arnica montana gel is safe, well-tolerated and effective in the treatment of mild to moderate osteoarthritis of the knee

Pubmed Data : Adv Ther. 2002 Sep-Oct;19(5):209-18. PMID: 12539881
Article Published Date : Sep 01, 2002
Study Type : Human Study
Additional Links
Substances : Arnica : CK(146) : AC(23)
Diseases : Osteoarthritis: Knee : CK(357) : AC(38)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433)

Bing sweet cherries appear to reduce inflammation in healthy persons.

Pubmed Data : J Nutr. 2006 Apr;136(4):981-6. PMID: 16549461
Article Published Date : Apr 01, 2006
Study Type : Human Study
Additional Links
Substances : Sweet Cherry : CK(12) : AC(3)
Diseases : Inflammation : CK(1077) : AC(363)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433)

Blueberry ingestion improves natural killer cell counts, oxidative stress, and inflammation prior to and after 2.5 h of running.

Pubmed Data : Appl Physiol Nutr Metab. 2011 Dec ;36(6):976-84. Epub 2011 Nov 23. PMID: 22111516
Article Published Date : Dec 01, 2011
Study Type : Human Study
Additional Links
Substances : Blueberry : CK(140) : AC(39)
Diseases : Low Immune Function: Exercise-Induced : CK(40) : AC(4), Low Immune Function: Natural Killer Cells : CK(108) : AC(21)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Antioxidants : CK(3653) : AC(1318)

Blueberry leaf extract reduces fasting glucose, C-reactive protein and plasma aminotransferases in patients with diabetes type 2.

Pubmed Data : Georgian Med News. 2006 Dec;(141):66-72. PMID: 17261891
Article Published Date : Dec 01, 2006
Study Type : Human Study
Additional Links
Substances : Blueberry : CK(140) : AC(39)
Diseases : ALT: Elevated : CK(60) : AC(10), C-Reactive Protein : CK(819) : AC(74), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), GGT : CK(73) : AC(10), Results for Liver Enzymes: Elevated AST : CK(34) : AC(4)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433)

Bromelain is effective in treating postoperative edema after third molar surgery.

Pubmed Data : Eur Rev Med Pharmacol Sci. 2010 Sep;14(9):771-4. PMID: 21061836
Article Published Date : Sep 01, 2010
Study Type : Human Study
Additional Links
Substances : Bromelain : CK(109) : AC(34)
Diseases : Edema : CK(107) : AC(13), Oral Surgical Procedures : CK(10) : AC(1), Postoperative Edema : CK(10) : AC(1), Postoperative Recovery : CK(100) : AC(9)
Pharmacological Actions : Analgesics : CK(372) : AC(78), Anti-Bacterial Agents : CK(970) : AC(316), Anti-Inflammatory Agents : CK(1230) : AC(433)
Additional Keywords : Dental : CK(15) : AC(1)

Camu camu (M. dubia) is superior to ascorbic acid in its anti-oxidant and anti-inflammatory properties in smokers.

Pubmed Data : J Cardiol. 2008 Oct;52(2):127-32. Epub 2008 Jul 29. PMID: 18922386
Article Published Date : Oct 01, 2008
Study Type : Human Study
Additional Links
Substances : Camu Camu : CK(10) : AC(1)
Diseases : Oxidative Stress : CK(1945) : AC(710), Smoking: Cardiovascular Disease : CK(60) : AC(6)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Antioxidants : CK(3653) : AC(1318)

Cats claw is an effective treatment for osteoarthritis.

Pubmed Data : Inflamm Res. 2001 Sep;50(9):442-8. PMID: 11603848
Article Published Date : Sep 01, 2001
Study Type : Human Study
Additional Links
Substances : Cat's Claw : CK(42) : AC(20)
Diseases : Osteoarthritis : CK(615) : AC(91), Osteoarthritis: Knee : CK(357) : AC(38)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Celadrin, a proprietary formula containing Cetyl Myristoleate, improves knee function in patients with osteoarthritis

Pubmed Data : J Rheumatol. 2002 Aug;29(8):1708-12. PMID: 12180734
Article Published Date : Aug 01, 2002
Study Type : Human Study
Additional Links
Substances : Celadrin : CK(20) : AC(2), Cetyl Myristoleate : CK(20) : AC(2)
Diseases : Osteoarthritis : CK(615) : AC(91)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433)
Additional Keywords : Natural Substances Versus Drugs : CK(988) : AC(165)

Chronic daily consumption of a resveratrol-containing grape nutraceutical could exert cardiovascular benefits in stable-CAD patients.

Pubmed Data : Cardiovasc Drugs Ther. 2012 Dec 8. Epub 2012 Dec 8. PMID: 23224687
Article Published Date : Dec 07, 2012
Study Type : Human Study
Additional Links
Substances : Resveratrol : CK(977) : AC(590)
Diseases : Adiponectin: Low Levels : CK(88) : AC(25), Coronary Artery Disease : CK(1305) : AC(136)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Cardioprotective : CK(702) : AC(196)

Congenital hypothyroidism and mental retardation may be linked to iodine and trace mineral deficiencies.

Pubmed Data : Sante. 2007 Jan-Mar;17(1):41-50. PMID: 17897901
Article Published Date : Jan 01, 2007
Study Type : Human Study
Additional Links
Diseases : Hypothyroidism : CK(537) : AC(78), Iodine Deficiency : CK(75) : AC(11), Mental Retardation : CK(71) : AC(7)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433)
Additional Keywords : Diseases that are Linked : CK(2122) : AC(270)

Consumption of pomegranate decreases serum oxidative stress and reduces disease activity in patients with active rheumatoid arthritis.

Pubmed Data : Isr Med Assoc J. 2011 Aug ;13(8):474-9. PMID: 21910371
Article Published Date : Aug 01, 2011
Study Type : Human Study
Additional Links
Substances : Pomegranate : CK(146) : AC(61)
Diseases : Lipid Peroxidation : CK(403) : AC(127), Rheumatoid Arthritis : CK(424) : AC(64)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Antioxidants : CK(3653) : AC(1318)

Curcumin has anti-inflammatory properties in patients with postoperative inflammation.

Pubmed Data : Int J Clin Pharmacol Ther Toxicol. 1986 Dec;24(12):651-4. PMID: 3546166
Article Published Date : Dec 01, 1986
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(2923) : AC(1482)
Diseases : Inflammation : CK(1077) : AC(363), Postoperative Recovery : CK(100) : AC(9)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433)

Curcumin improves ulcerative proctitis and Crohn's disease in patient s with inflammatory bowel disease.

Pubmed Data : Dig Dis Sci. 2005 Nov;50(11):2191-3. PMID: 16240238
Article Published Date : Nov 01, 2005
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(2923) : AC(1482)
Diseases : Inflammatory Bowel Diseases : CK(1227) : AC(103), Proctitis : CK(10) : AC(1), Proctocolitis: Ulcerative : CK(30) : AC(3)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433)

Curcumin induces programmed cell death and inhibits proinflammatory prostaglandin E2 production in synovial fibroblasts of patients with rheumatoid arthritis.

Pubmed Data : Int J Mol Med. 2007 Sep;20(3):365-72. PMID: 17671742
Article Published Date : Sep 01, 2007
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(2923) : AC(1482)
Diseases : Arthritis: Rheumatoid : CK(289) : AC(54), Rheumatoid Arthritis : CK(424) : AC(64)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433)

Data support pro- and anti-inflammatory roles within EFA metabolism

Pubmed Data : Prostaglandins Leukot Essent Fatty Acids. 1998 Oct ;59(4):239-45. PMID: 9849649
Article Published Date : Sep 30, 1998
Study Type : Human Study
Additional Links
Substances : DHA (Docosahexaenoic Acid) : CK(582) : AC(100), Essential Fatty Acids : CK(88) : AC(12)
Diseases : Sjogren's Syndrome : CK(81) : AC(14)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433)
Additional Keywords : cell membranes, essential fatty acids, sjogrens syndrome

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