Anti-metastatic

Anti-metastatic

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Quick Summary: Current access displays 2 out of 74 associated Substances
NameCumulative KnowledgeArticle CountFocus Articles
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View the Evidence: Pharmacological Actions

Bromelain has antimetastic protential as demonstrated in lung cancer cells - Article 1.

Pubmed Data : J Cancer Res Clin Oncol. 1988;114(5):507-8. PMID: 3182910
Article Published Date : Jan 01, 1988
Study Type : Human Study
Additional Links
Substances : Bromelain : CK(141) : AC(34), Pineapple : CK(141) : AC(39)
Diseases : Lung Cancer : CK(494) : AC(198)
Pharmacological Actions : Anti-metastatic : CK(169) : AC(106)

FOLFIRI and FOLFOX6 chemotherapies result in a median progression free survival time of between 7.7 and 8.4 months.

Pubmed Data : Jpn J Clin Oncol. 2010 Jul;40(7):634-8. PMID: 20587616
Article Published Date : Jul 01, 2010
Study Type : Human Study
Additional Links
Diseases : Colorectal Cancer : CK(809) : AC(303)
Pharmacological Actions : Anti-metastatic : CK(169) : AC(106)
Additional Keywords : Drug: 5-flourouracil : CK(88) : AC(22)
Anti Therapeutic Actions : Chemotherapy : CK(248) : AC(36)

Tea polyphenol has potential to be a therapeutic adjuvant against human metastatic breast cancer.

Pubmed Data : Curr Mol Med. 2012 Feb 1 ;12(2):163-76. PMID: 22280355
Article Published Date : Feb 01, 2012
Study Type : Human Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(848) : AC(109)
Diseases : Breast Cancer : CK(2051) : AC(566), Breast Cancer: Metastatic : CK(79) : AC(31)
Pharmacological Actions : Anti-metastatic : CK(169) : AC(106), Radiosensitizer : CK(50) : AC(27)
Additional Keywords : Drug Synergy : CK(324) : AC(144)

"Antineoplaston A in cancer therapy. (I)."

Pubmed Data : Physiol Chem Phys. 1977 ;9(6):485-500. PMID: 275868
Article Published Date : Jan 01, 1977
Study Type : Human: Case Report
Additional Links
Substances : Antineoplastons : CK(134) : AC(36)
Pharmacological Actions : Anti-metastatic : CK(169) : AC(106), Antineoplastic Agents : CK(833) : AC(457)

"Phase I clinical studies of antineoplaston A5 injections."

Pubmed Data : Drugs Exp Clin Res. 1987 ;13 Suppl 1:37-43. PMID: 3569014
Article Published Date : Jan 01, 1987
Study Type : Human: Case Report
Additional Links
Substances : Antineoplaston A5 : CK(3) : AC(1)
Diseases : Bladder Cancer : CK(179) : AC(60), Breast Cancer : CK(2051) : AC(566), Colorectal Cancer : CK(809) : AC(303), Lung Cancer : CK(494) : AC(198)
Pharmacological Actions : Anti-metastatic : CK(169) : AC(106), Antineoplastic Agents : CK(833) : AC(457), Chemopreventive : CK(1314) : AC(355)

Antineoplaston A2 has anticancer effects.

Pubmed Data : Drugs Exp Clin Res. 1987 ;13 Suppl 1:1-11. PMID: 3569010
Article Published Date : Jan 01, 1987
Study Type : Human: Case Report
Additional Links
Substances : Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine) : CK(92) : AC(1)
Diseases : Bladder Cancer : CK(179) : AC(60), Breast Cancer : CK(2051) : AC(566), Esophageal Cancer : CK(323) : AC(55), Liver Cancer: Metastatic : CK(6) : AC(2), Lung Cancer : CK(494) : AC(198), Mesothelioma : CK(30) : AC(10)
Pharmacological Actions : Anti-metastatic : CK(169) : AC(106), Antineoplastic Agents : CK(833) : AC(457)

Case report: long-term survival following treatment with antineoplastons for colon cancer with unresectable multiple liver metastases.

Pubmed Data : Surg Today. 2003 ;33(6):448-53. PMID: 12768372
Article Published Date : Jan 01, 2003
Study Type : Human: Case Report
Additional Links
Substances : Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine) : CK(92) : AC(1)
Diseases : Colon Cancer : CK(819) : AC(233), Liver Cancer : CK(1577) : AC(266), Liver Cancer: Metastatic : CK(6) : AC(2), Liver Metastasis From Colon Cancer : CK(3) : AC(1)
Pharmacological Actions : Anti-metastatic : CK(169) : AC(106)

"Antineoplaston AS2-1 showed an antimetastatic effect against post-operative lung metastases from colon cancer through G1 cell arrest and the subsequent induction of apoptosis."

Pubmed Data : Oncol Rep. 2005 Mar ;13(3):389-95. PMID: 15706406
Article Published Date : Mar 01, 2005
Study Type : Animal Study
Additional Links
Substances : Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine) : CK(92) : AC(1)
Diseases : Cancer Metastasis : CK(252) : AC(135), Colon Cancer : CK(819) : AC(233), Lung Cancer: Metastatic : CK(4) : AC(1), Post-Operative Lung Metastasis of Colon Cancer : CK(2) : AC(1)
Pharmacological Actions : Anti-metastatic : CK(169) : AC(106), Apoptotic : CK(1416) : AC(1089), Cell cycle arrest : CK(371) : AC(309)

A mixture containing ascorbic acid, lysine, proline and green tea extract inhibits angiogenesis of tumor cells.

Pubmed Data : Carcinogenesis. 2006 Dec;27(12):2424-33. Epub 2006 Jun 19. PMID: 16142336
Article Published Date : Dec 01, 2006
Study Type : Animal Study
Additional Links
Substances : Green Tea : CK(952) : AC(283), Lysine : CK(99) : AC(21), Proline : CK(19) : AC(8), Vitamin C : CK(1178) : AC(238)
Diseases : Cancer Metastasis : CK(252) : AC(135), Tumors : CK(193) : AC(110)
Pharmacological Actions : Anti-metastatic : CK(169) : AC(106), Antiproliferative : CK(969) : AC(725), Vascular Endothelial Growth Factor A Inhibitor : CK(102) : AC(58)
Additional Keywords : Plant Extracts : CK(3401) : AC(1158)

Astaxanthin inhibits liver metastasis of mastocytoma cells in an animal model.

Pubmed Data : Life Sci. 2002 Apr 21;70(21):2509-20. PMID: 12173414
Article Published Date : Apr 21, 2002
Study Type : Animal Study
Additional Links
Substances : Astaxanthin : CK(600) : AC(111)
Diseases : Mastocytoma : CK(11) : AC(7)
Pharmacological Actions : Anti-metastatic : CK(169) : AC(106)

Blueberry supresses the growth and metastasis of triple negative breast tumors in animals.

Pubmed Data : J Nutr. 2011 Aug 31. Epub 2011 Aug 31. PMID: 21880954
Article Published Date : Aug 31, 2011
Study Type : Animal Study
Additional Links
Substances : Blueberry : CK(131) : AC(42)
Diseases : Breast Cancer: Metastatic : CK(79) : AC(31), Breast Cancer: Triple Negative : CK(58) : AC(10), Cancer Metastasis : CK(252) : AC(135)
Pharmacological Actions : Anti-metastatic : CK(169) : AC(106), Chemopreventive : CK(1314) : AC(355)

Boswellic acid suppresses growth and metastatis of human pancreatic tumors (nude mouse model).

Pubmed Data : PLoS One. 2011 ;6(10):e26943. Epub 2011 Oct 31. PMID: 22066019
Article Published Date : Jan 01, 2011
Study Type : Transgenic Animal Study
Additional Links
Substances : Boswellia : CK(122) : AC(31)
Diseases : Cancer Metastasis : CK(252) : AC(135), Pancreatic Cancer : CK(513) : AC(162)
Pharmacological Actions : Anti-metastatic : CK(169) : AC(106), Apoptotic : CK(1416) : AC(1089), Cyclooxygenase 2 Inhibitors : CK(274) : AC(169), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(47) : AC(27), Vascular Endothelial Growth Factor Inhibitors : CK(13) : AC(8)

Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1.

Pubmed Data : FASEB J. 2012 Apr ;26(4):1535-48. Epub 2011 Dec 23. PMID: 22198381
Article Published Date : Apr 01, 2012
Study Type : Animal Study
Additional Links
Substances : Cannabidiol : CK(369) : AC(92)
Diseases : Cancer Metastasis : CK(252) : AC(135), Lung Cancer : CK(494) : AC(198)
Pharmacological Actions : Anti-metastatic : CK(169) : AC(106), Intracellular adhesion molecule-1 (ICAM-1) : CK(4) : AC(3)

Collards and cabbage prevent pulmonary metastasis of mammary cancer in mice.

Pubmed Data : Nutr Cancer. 1989;12(2):121-6. PMID: 2710654
Article Published Date : Jan 01, 1989
Study Type : Animal Study
Additional Links
Substances : Cabbage : CK(65) : AC(13), Collards : CK(53) : AC(6)
Diseases : Breast Cancer : CK(2051) : AC(566), Breast Cancer: Lung Metastasis : CK(13) : AC(7), Cancer Metastasis : CK(252) : AC(135), Lung Cancer : CK(494) : AC(198)
Pharmacological Actions : Anti-metastatic : CK(169) : AC(106), Chemopreventive : CK(1314) : AC(355)

Curcumin exhibits chemopreventive properties in hematogenous breast cancer metastases in immunodeficient mice.

Pubmed Data : Cell Physiol Biochem. 2007;19(1-4):137-52. PMID: 17310108
Article Published Date : Jan 01, 2007
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2890) : AC(1511), Flavonoids : CK(868) : AC(290), Polyphenols : CK(412) : AC(169)
Diseases : Breast Cancer : CK(2051) : AC(566), Cancer Metastasis : CK(252) : AC(135), Immune Disorders: Low Immune Function : CK(488) : AC(115), Lung Cancer : CK(494) : AC(198)
Pharmacological Actions : Anti-metastatic : CK(169) : AC(106), Antineoplastic Agents : CK(833) : AC(457), Apoptotic : CK(1416) : AC(1089), NF-kappaB Inhibitor : CK(599) : AC(397)

Curcumin inhibits lung cancer cell metastasis.

Pubmed Data : Clin Exp Metastasis. 2000;18(7):539-45. PMID: 11688958
Article Published Date : Jan 01, 2000
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2890) : AC(1511)
Diseases : Cancer Metastasis : CK(252) : AC(135), Chemotherapy-Induced Toxicity: Cisplatin : CK(165) : AC(66), Lung Cancer : CK(494) : AC(198)
Pharmacological Actions : Anti-metastatic : CK(169) : AC(106), Antineoplastic Agents : CK(833) : AC(457), Antiproliferative : CK(969) : AC(725)

Dietary fish oil inhibits metastasizing human breast cancer cells.

Pubmed Data : Nutr Cancer. 1994;22(2):131-41. PMID: 14502842
Article Published Date : Jan 01, 1994
Study Type : Animal Study
Additional Links
Substances : Fish Oil : CK(613) : AC(94)
Diseases : Breast Cancer : CK(2051) : AC(566), Cancer Metastasis : CK(252) : AC(135)
Pharmacological Actions : Anti-metastatic : CK(169) : AC(106), Antiproliferative : CK(969) : AC(725)

Dietary stearate reduces human breast cancer metastasis burden in athymic nude mice.

Pubmed Data : Clin Exp Metastasis. 2009;26(5):415-24. Epub 2009 Mar 8. PMID: 19267249
Article Published Date : Jan 01, 2009
Study Type : Animal Study
Additional Links
Substances : Stearic Acid (stearate) : CK(23) : AC(8)
Diseases : Breast Cancer: Metastatic : CK(79) : AC(31)
Pharmacological Actions : Anti-metastatic : CK(169) : AC(106)

Diets containing EPA and DHA have an inhibitory effect on breast cancer growth and metastasis.

Pubmed Data : J Natl Cancer Inst. 1995 Apr 19;87(8):587-92. PMID: 7752256
Article Published Date : Apr 19, 1995
Study Type : Animal Study
Additional Links
Substances : DHA (Docosahexaenoic Acid) : CK(562) : AC(100), EPA (Eicosapentaenoic Acid) : CK(575) : AC(84)
Diseases : Breast Cancer : CK(2051) : AC(566), Cancer Metastasis : CK(252) : AC(135)
Pharmacological Actions : Anti-metastatic : CK(169) : AC(106)

DIM inhibits lung metastasis of mammary cancer cells in mice.

Pubmed Data : J Nutr. 2009 Oct 28. PMID: 19864400
Article Published Date : Oct 28, 2009
Study Type : Animal Study
Additional Links
Substances : DIM (3,3'-diindolylmethane) : CK(17) : AC(6)
Diseases : Breast Cancer : CK(2051) : AC(566), Breast Cancer: Lung Metastasis : CK(13) : AC(7)
Pharmacological Actions : Anti-metastatic : CK(169) : AC(106)

Emodin exerts anti-metastatic activity in pancreatic cancer both in vitro and in vivo.

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2011 Nov ;36(22):3167-71. PMID: 22375400
Article Published Date : Nov 01, 2011
Study Type : Animal Study
Additional Links
Substances : Emodin : CK(32) : AC(19)
Diseases : Cancer Metastasis : CK(252) : AC(135), Pancreatic Cancer : CK(513) : AC(162), Pancreatic Cancer: Metastatic : CK(2) : AC(1)
Pharmacological Actions : Anti-Angiogenic : CK(136) : AC(101), Anti-metastatic : CK(169) : AC(106), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(47) : AC(27), NF-kappaB Inhibitor : CK(599) : AC(397)

Forskolin has antimetastatic potential.

Pubmed Data : Int J Cancer. 1983 Dec 15;32(6):801-4. PMID: 6686215
Article Published Date : Dec 15, 1983
Study Type : Animal Study
Additional Links
Substances : Coleus Forskohlii : CK(22) : AC(9)
Diseases : Cancer Metastasis : CK(252) : AC(135)
Pharmacological Actions : Anti-metastatic : CK(169) : AC(106)

Ganoderma lucidum inhibits tumorigenesis and metastasis of human hepatoma cells in cells and animal models.

Pubmed Data : J Agric Food Chem. 2009 Jun 10 ;57(11):5049-57. PMID: 19422227
Article Published Date : Jun 10, 2009
Study Type : Animal Study
Additional Links
Substances : Reishi Mushroom : CK(114) : AC(46)
Diseases : Cancer Metastasis : CK(252) : AC(135), Liver Cancer : CK(1577) : AC(266)
Pharmacological Actions : Anti-metastatic : CK(169) : AC(106), Antineoplastic Agents : CK(833) : AC(457)
Additional Keywords : Plant Extracts : CK(3401) : AC(1158)

Genistein inhibits metastasis of human prostate cancer in mice.

Pubmed Data : Ann Thorac Surg. 2010 Mar;89(3):781-786. PMID: 18339885
Article Published Date : Mar 01, 2010
Study Type : Transgenic Animal Study
Additional Links
Substances : Genistein : CK(436) : AC(174)
Diseases : Cancer Metastasis : CK(252) : AC(135), Prostate Cancer : CK(956) : AC(288)
Pharmacological Actions : Anti-metastatic : CK(169) : AC(106)

Germanium prevents pulmonary metastasis of Lewis lung cancer.

Pubmed Data : Eur J Appl Physiol. 2008 May;103(1):33-40. Epub 2008 Jan 11. PMID: 3373232
Article Published Date : May 01, 2008
Study Type : Animal Study
Additional Links
Substances : Germanium : CK(12) : AC(7)
Diseases : Breast Cancer: Metastatic : CK(79) : AC(31), Lung Cancer : CK(494) : AC(198)
Pharmacological Actions : Anti-metastatic : CK(169) : AC(106)

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