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Anti-metastatic

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Article Count - 115
Cumulative Knowledge - 200

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Cancer Metastasis

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View the Evidence: Pharmacological Actions

"Although BRCA positive patients have more frequently negative prognostic factors, their prognosis appears to be equal to or better than in patients with BRCA-WT."

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Cancer. 2005 ;5:70. Epub 2005 Jul 4. PMID: 15996267

Article Published Date : Dec 31, 2004

Study Type : Human Study

Additional Links

Diseases : BRCA1/BRCA2: Prevalence : CK(50) : AC(5)

Pharmacological Actions : Anti-metastatic : CK(192) : AC(115)

Additional Keywords : BRCA MYTH : CK(0) : AC(3)

Bromelain has antimetastic protential as demonstrated in lung cancer cells - Article 1.

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Pubmed Data : J Cancer Res Clin Oncol. 1988;114(5):507-8. PMID: 3182910

Article Published Date : Jan 01, 1988

Study Type : Human Study

Additional Links

Substances : Bromelain : CK(109) : AC(34), Pineapple : CK(141) : AC(39)

Diseases : Lung Cancer : CK(496) : AC(198)

Pharmacological Actions : Anti-metastatic : CK(192) : AC(115)

FOLFIRI and FOLFOX6 chemotherapies result in a median progression free survival time of between 7.7 and 8.4 months.

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Pubmed Data : Jpn J Clin Oncol. 2010 Jul;40(7):634-8. PMID: 20587616

Article Published Date : Jul 01, 2010

Study Type : Human Study

Additional Links

Diseases : Colorectal Cancer : CK(877) : AC(321)

Pharmacological Actions : Anti-metastatic : CK(192) : AC(115)

Additional Keywords : Drug: 5-flourouracil : CK(88) : AC(22)

Anti Therapeutic Actions : Chemotherapy : CK(257) : AC(38)

Tea polyphenol has potential to be a therapeutic adjuvant against human metastatic breast cancer.

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Pubmed Data : Curr Mol Med. 2012 Feb 1 ;12(2):163-76. PMID: 22280355

Article Published Date : Feb 01, 2012

Study Type : Human Study

Additional Links

Substances : EGCG (Epigallocatechin gallate) : CK(859) : AC(109)

Diseases : Breast Cancer : CK(2354) : AC(621), Breast Cancer: Metastatic : CK(82) : AC(33)

Pharmacological Actions : Anti-metastatic : CK(192) : AC(115), Radiosensitizer : CK(50) : AC(29)

Additional Keywords : Drug Synergy : CK(327) : AC(147)

"Antineoplaston A in cancer therapy. (I)."

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Pubmed Data : Physiol Chem Phys. 1977 ;9(6):485-500. PMID: 275868

Article Published Date : Jan 01, 1977

Study Type : Human: Case Report

Additional Links

Substances : Antineoplastons : CK(134) : AC(36)

Pharmacological Actions : Anti-metastatic : CK(192) : AC(115), Antineoplastic Agents : CK(877) : AC(496)

"Phase I clinical studies of antineoplaston A5 injections."

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Pubmed Data : Drugs Exp Clin Res. 1987 ;13 Suppl 1:37-43. PMID: 3569014

Article Published Date : Jan 01, 1987

Study Type : Human: Case Report

Additional Links

Substances : Antineoplaston A5 : CK(3) : AC(1)

Diseases : Bladder Cancer : CK(186) : AC(60), Breast Cancer : CK(2354) : AC(621), Colorectal Cancer : CK(877) : AC(321), Lung Cancer : CK(496) : AC(198)

Pharmacological Actions : Anti-metastatic : CK(192) : AC(115), Antineoplastic Agents : CK(877) : AC(496), Chemopreventive : CK(1528) : AC(382)

Antineoplaston A2 has anticancer effects.

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Pubmed Data : Drugs Exp Clin Res. 1987 ;13 Suppl 1:1-11. PMID: 3569010

Article Published Date : Jan 01, 1987

Study Type : Human: Case Report

Additional Links

Substances : Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine) : CK(92) : AC(1)

Diseases : Bladder Cancer : CK(186) : AC(60), Breast Cancer : CK(2354) : AC(621), Esophageal Cancer : CK(328) : AC(55), Liver Cancer: Metastatic : CK(6) : AC(2), Lung Cancer : CK(496) : AC(198), Mesothelioma : CK(30) : AC(10)

Pharmacological Actions : Anti-metastatic : CK(192) : AC(115), Antineoplastic Agents : CK(877) : AC(496)

Case report: long-term survival following treatment with antineoplastons for colon cancer with unresectable multiple liver metastases.

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Pubmed Data : Surg Today. 2003 ;33(6):448-53. PMID: 12768372

Article Published Date : Jan 01, 2003

Study Type : Human: Case Report

Additional Links

Substances : Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine) : CK(92) : AC(1)

Diseases : Colon Cancer : CK(895) : AC(233), Liver Cancer : CK(1641) : AC(266), Liver Cancer: Metastatic : CK(6) : AC(2), Liver Metastasis From Colon Cancer : CK(3) : AC(1)

Pharmacological Actions : Anti-metastatic : CK(192) : AC(115)

"Anti-metastasis effect of thymoquinone on human pancreatic cancer"

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Pubmed Data : Yao Xue Xue Bao. 2011 Aug ;46(8):910-4. PMID: 22007514

Article Published Date : Jul 31, 2011

Study Type : Animal Study

Additional Links

Substances : Thymoquinone : CK(3) : AC(1)

Diseases : Cancer Metastasis : CK(272) : AC(135), Pancreatic Cancer: Metastatic : CK(2) : AC(1)

Pharmacological Actions : Anti-metastatic : CK(192) : AC(115)

"Antineoplaston AS2-1 showed an antimetastatic effect against post-operative lung metastases from colon cancer through G1 cell arrest and the subsequent induction of apoptosis."

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Pubmed Data : Oncol Rep. 2005 Mar ;13(3):389-95. PMID: 15706406

Article Published Date : Mar 01, 2005

Study Type : Animal Study

Additional Links

Substances : Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine) : CK(92) : AC(1)

Diseases : Cancer Metastasis : CK(272) : AC(135), Colon Cancer : CK(895) : AC(233), Lung Cancer: Metastatic : CK(4) : AC(1), Post-Operative Lung Metastasis of Colon Cancer : CK(2) : AC(1)

Pharmacological Actions : Anti-metastatic : CK(192) : AC(115), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)

A mixture containing ascorbic acid, lysine, proline and green tea extract inhibits angiogenesis of tumor cells.

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Pubmed Data : Carcinogenesis. 2006 Dec;27(12):2424-33. Epub 2006 Jun 19. PMID: 16142336

Article Published Date : Dec 01, 2006

Study Type : Animal Study

Additional Links

Substances : Green Tea : CK(930) : AC(294), Lysine : CK(99) : AC(21), Proline : CK(19) : AC(8), Vitamin C : CK(1274) : AC(238)

Diseases : Cancer Metastasis : CK(272) : AC(135), Tumors : CK(197) : AC(110)

Pharmacological Actions : Anti-metastatic : CK(192) : AC(115), Antiproliferative : CK(1052) : AC(775), Vascular Endothelial Growth Factor A Inhibitor : CK(102) : AC(58)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Astaxanthin inhibits liver metastasis of mastocytoma cells in an animal model.

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Pubmed Data : Life Sci. 2002 Apr 21;70(21):2509-20. PMID: 12173414

Article Published Date : Apr 21, 2002

Study Type : Animal Study

Additional Links

Substances : Astaxanthin : CK(353) : AC(117)

Diseases : Mastocytoma : CK(11) : AC(7)

Pharmacological Actions : Anti-metastatic : CK(192) : AC(115)

Bicarbonate increases tumor pH and inhibits spontaneous metastases.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer Res. 2009 Mar 15 ;69(6):2260-8. Epub 2009 Mar 10. PMID: 19276390

Article Published Date : Mar 14, 2009

Study Type : Animal Study

Additional Links

Substances : Baking Soda : CK(14) : AC(3)

Diseases : Breast Cancer: Metastatic : CK(82) : AC(33), Cancer-Acidosis Connection : CK(1) : AC(1)

Pharmacological Actions : Anti-metastatic : CK(192) : AC(115)

Blueberry supresses the growth and metastasis of triple negative breast tumors in animals.

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Pubmed Data : J Nutr. 2011 Aug 31. Epub 2011 Aug 31. PMID: 21880954

Article Published Date : Aug 31, 2011

Study Type : Animal Study

Additional Links

Substances : Blueberry : CK(140) : AC(39)

Diseases : Breast Cancer: Metastatic : CK(82) : AC(33), Breast Cancer: Triple Negative : CK(61) : AC(13), Cancer Metastasis : CK(272) : AC(135)

Pharmacological Actions : Anti-metastatic : CK(192) : AC(115), Chemopreventive : CK(1528) : AC(382)

Boswellic acid suppresses growth and metastatis of human pancreatic tumors (nude mouse model).

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Pubmed Data : PLoS One. 2011 ;6(10):e26943. Epub 2011 Oct 31. PMID: 22066019

Article Published Date : Jan 01, 2011

Study Type : Transgenic Animal Study

Additional Links

Substances : Boswellia : CK(122) : AC(31)

Diseases : Cancer Metastasis : CK(272) : AC(135), Pancreatic Cancer : CK(530) : AC(168)

Pharmacological Actions : Anti-metastatic : CK(192) : AC(115), Apoptotic : CK(1489) : AC(1114), Cyclooxygenase 2 Inhibitors : CK(269) : AC(169), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(49) : AC(30), Vascular Endothelial Growth Factor Inhibitors : CK(13) : AC(8)

Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1.

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Pubmed Data : FASEB J. 2012 Apr ;26(4):1535-48. Epub 2011 Dec 23. PMID: 22198381

Article Published Date : Apr 01, 2012

Study Type : Animal Study

Additional Links

Substances : Cannabidiol : CK(391) : AC(92)

Diseases : Cancer Metastasis : CK(272) : AC(135), Lung Cancer : CK(496) : AC(198)

Pharmacological Actions : Anti-metastatic : CK(192) : AC(115), Intracellular adhesion molecule-1 (ICAM-1) : CK(4) : AC(3)

Collards and cabbage prevent pulmonary metastasis of mammary cancer in mice.

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Pubmed Data : Nutr Cancer. 1989;12(2):121-6. PMID: 2710654

Article Published Date : Jan 01, 1989

Study Type : Animal Study

Additional Links

Substances : Cabbage : CK(65) : AC(13), Collards : CK(53) : AC(6)

Diseases : Breast Cancer : CK(2354) : AC(621), Breast Cancer: Lung Metastasis : CK(13) : AC(7), Cancer Metastasis : CK(272) : AC(135), Lung Cancer : CK(496) : AC(198)

Pharmacological Actions : Anti-metastatic : CK(192) : AC(115), Chemopreventive : CK(1528) : AC(382)

Curcumin exhibits chemopreventive properties in hematogenous breast cancer metastases in immunodeficient mice.

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Pubmed Data : Cell Physiol Biochem. 2007;19(1-4):137-52. PMID: 17310108

Article Published Date : Jan 01, 2007

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482), Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)

Diseases : Breast Cancer : CK(2354) : AC(621), Cancer Metastasis : CK(272) : AC(135), Immune Disorders: Low Immune Function : CK(488) : AC(115), Lung Cancer : CK(496) : AC(198)

Pharmacological Actions : Anti-metastatic : CK(192) : AC(115), Antineoplastic Agents : CK(877) : AC(496), Apoptotic : CK(1489) : AC(1114), NF-kappaB Inhibitor : CK(595) : AC(401)

Curcumin inhibits lung cancer cell metastasis.

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Pubmed Data : Clin Exp Metastasis. 2000;18(7):539-45. PMID: 11688958

Article Published Date : Jan 01, 2000

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Cancer Metastasis : CK(272) : AC(135), Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66), Lung Cancer : CK(496) : AC(198)

Pharmacological Actions : Anti-metastatic : CK(192) : AC(115), Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1052) : AC(775)

Dietary fish oil inhibits metastasizing human breast cancer cells.

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Pubmed Data : Nutr Cancer. 1994;22(2):131-41. PMID: 14502842

Article Published Date : Jan 01, 1994

Study Type : Animal Study

Additional Links

Substances : Fish Oil : CK(615) : AC(95)

Diseases : Breast Cancer : CK(2354) : AC(621), Cancer Metastasis : CK(272) : AC(135)

Pharmacological Actions : Anti-metastatic : CK(192) : AC(115), Antiproliferative : CK(1052) : AC(775)

Dietary stearate reduces human breast cancer metastasis burden in athymic nude mice.

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Pubmed Data : Clin Exp Metastasis. 2009;26(5):415-24. Epub 2009 Mar 8. PMID: 19267249

Article Published Date : Jan 01, 2009

Study Type : Animal Study

Additional Links

Substances : Stearic Acid (stearate) : CK(23) : AC(8)

Diseases : Breast Cancer: Metastatic : CK(82) : AC(33)

Pharmacological Actions : Anti-metastatic : CK(192) : AC(115)

Diets containing EPA and DHA have an inhibitory effect on breast cancer growth and metastasis.

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Pubmed Data : J Natl Cancer Inst. 1995 Apr 19;87(8):587-92. PMID: 7752256

Article Published Date : Apr 19, 1995

Study Type : Animal Study

Additional Links

Substances : DHA (Docosahexaenoic Acid) : CK(582) : AC(100), EPA (Eicosapentaenoic Acid) : CK(595) : AC(84)

Diseases : Breast Cancer : CK(2354) : AC(621), Cancer Metastasis : CK(272) : AC(135)

Pharmacological Actions : Anti-metastatic : CK(192) : AC(115)

DIM inhibits lung metastasis of mammary cancer cells in mice.

Click here to read the entire abstract

Pubmed Data : J Nutr. 2009 Oct 28. PMID: 19864400

Article Published Date : Oct 28, 2009

Study Type : Animal Study

Additional Links

Substances : DIM (3,3'-diindolylmethane) : CK(17) : AC(6)

Diseases : Breast Cancer : CK(2354) : AC(621), Breast Cancer: Lung Metastasis : CK(13) : AC(7)

Pharmacological Actions : Anti-metastatic : CK(192) : AC(115)

Emodin exerts anti-metastatic activity in pancreatic cancer both in vitro and in vivo.

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Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2011 Nov ;36(22):3167-71. PMID: 22375400

Article Published Date : Nov 01, 2011

Study Type : Animal Study

Additional Links

Substances : Emodin : CK(32) : AC(19)

Diseases : Cancer Metastasis : CK(272) : AC(135), Pancreatic Cancer : CK(530) : AC(168), Pancreatic Cancer: Metastatic : CK(2) : AC(1)

Pharmacological Actions : Anti-Angiogenic : CK(143) : AC(101), Anti-metastatic : CK(192) : AC(115), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(49) : AC(30), NF-kappaB Inhibitor : CK(595) : AC(401)

Forskolin has antimetastatic potential.

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Pubmed Data : Int J Cancer. 1983 Dec 15;32(6):801-4. PMID: 6686215

Article Published Date : Dec 15, 1983

Study Type : Animal Study

Additional Links

Substances : Coleus Forskohlii : CK(22) : AC(9)

Diseases : Cancer Metastasis : CK(272) : AC(135)

Pharmacological Actions : Anti-metastatic : CK(192) : AC(115)

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Two recent studies have found that a constituent of olives and olive oil inhibits the growth of breast cancer and the development of Alzheimer's disease.

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