Anti-Ulcer Agents

User Options

A Membership is required. Please Login or Create an account to get startedRequest us to build a Downloadable Document Product on this TopicMake a Request for GMI to add more Articles on this Topic Immediately (Purchase Required)View a Printer Friendly version of this pageE-mail this page to a friendPerform a Search with this Topic
Hover over an icon for more information

Additional Topics Details for this Page

  • - 57
  • - 162
View the Evidence: Pharmacological Actions

Adding vitamin C to one-week triple therapy can reduce the dosage of clarithromycin, but preserve the high eradication efficacy for clarithromycin susceptible H. pylori infection.

Pubmed Data : Hepatogastroenterology. 2007 Jan-Feb;54(73):320-4. PMID: 17419283
Article Published Date : Jan 01, 2007
Study Type : Human Study
Additional Links
Substances : Vitamin C : CK(1274) : AC(238)
Diseases : Duodenal Ulcer : CK(89) : AC(26), Gastric Ulcer : CK(246) : AC(91), Helicobacter Pylori Infection : CK(305) : AC(61)
Pharmacological Actions : Anti-Bacterial Agents : CK(970) : AC(316), Anti-Ulcer Agents : CK(162) : AC(57)
Additional Keywords : Drug: Amoxicillin : CK(60) : AC(6), Drug: Omeprazole : CK(90) : AC(15)

Black cumin possesses clinical useful anti-H. pylori activity compared to triple therapy.

Pubmed Data : Saudi J Gastroenterol. 2010 Jul-Sep;16(3):207-14. PMID: 20616418
Article Published Date : Jul 01, 2010
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed) : CK(133) : AC(34)
Diseases : Dyspepsia : CK(422) : AC(21), Helicobacter Pylori Infection : CK(305) : AC(61)
Pharmacological Actions : Anti-Bacterial Agents : CK(970) : AC(316), Anti-Ulcer Agents : CK(162) : AC(57)
Additional Keywords : Drug: Amoxicillin : CK(60) : AC(6), Drug: Omeprazole : CK(90) : AC(15), Drug-Plant-Vitamin Synergies : CK(1011) : AC(268), Natural Substances Versus Drugs : CK(988) : AC(165), Plant Extracts : CK(3572) : AC(1216)

Licorice reverses duodenal ulceration.

Pubmed Data : Practitioner. 1975 Dec;215(1290):787-92. PMID: 772652
Article Published Date : Dec 01, 1975
Study Type : Human Study
Additional Links
Substances : Licorice : CK(257) : AC(81)
Diseases : Duodenal Ulcer : CK(89) : AC(26)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57)

Ranitidine inhibits the secretion of gastric intrinsic factor and absorption of vitamin B 12

Pubmed Data : Gastroenterol Clin Biol. 1983 Apr ;7(4):381-4. PMID: 6135642
Article Published Date : Apr 01, 1983
Study Type : Human Study
Additional Links
Substances : Vitamin B-12 : CK(752) : AC(94)
Diseases : Acid Reflux : CK(288) : AC(42), Drug-Induced Nutrient Depletion: Vitamin B-12 : CK(20) : AC(2), Vitamin B 12 Deficiency : CK(220) : AC(34)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57)
Problem Substances : Histamine Receptor Antagonists : CK(97) : AC(12), Ranitidine : CK(10) : AC(1)

SCENAR therapy has a beneficial action in the treatment of duodenal ulcer.

Pubmed Data : Klin Med (Mosk). 2006;84(7):35-41. PMID: 16924799
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Diseases : Duodenal Ulcer : CK(89) : AC(26)
Therapeutic Actions : SCENAR Therapy (electronic biofeedback) : CK(34) : AC(4)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57)

Short-term administration of low-dose aspirin is associated with small bowel injuries and blood flow.

Pubmed Data : World J Gastroenterol. 2011 Jan 14 ;17(2):226-30. PMID: 21245996
Article Published Date : Jan 14, 2011
Study Type : Human Study
Additional Links
Diseases : Aspirin-Induced Toxicity : CK(83) : AC(24), Gastrointestinal Hemorrhage : CK(33) : AC(4), NSAID-induced toxicity : CK(230) : AC(50)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57)
Problem Substances : Aspirin : CK(471) : AC(64)

A natural flavonoid present in unripe plantain banana pulp (Musa sapientum L. var. paradisiaca) protects the gastric mucosa from aspirin-induced erosions.

Pubmed Data : J Ethnopharmacol. 1999 Jun;65(3):283-8. PMID: 10404428
Article Published Date : Jun 01, 1999
Study Type : Animal Study
Additional Links
Substances : Banana : CK(123) : AC(36), Flavonoids : CK(909) : AC(289)
Diseases : Aspirin-Induced Toxicity : CK(83) : AC(24), NSAID-induced toxicity : CK(230) : AC(50)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57)

An aqueous decoction of mango flowers has potential gastroprotective and ulcer-healing properties.

Pubmed Data : Planta Med. 2004 Aug;70(8):745-52. PMID: 16500058
Article Published Date : Aug 01, 2004
Study Type : Animal Study
Additional Links
Substances : Flavonoids : CK(909) : AC(289), Flowers : CK(27) : AC(14), Mango : CK(60) : AC(34), Polyphenols : CK(427) : AC(174)
Diseases : Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57), Cyclooxygenase Inhibitors : CK(64) : AC(32)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Antiulcerogenic and antibacterial activities of celery essential oil and extract.

Pubmed Data : Nat Prod Res. 2012 Aug 30. Epub 2012 Aug 30. PMID: 22934666
Article Published Date : Aug 29, 2012
Study Type : Animal Study
Additional Links
Substances : Celery Oil : CK(4) : AC(2)
Diseases : Escherichia coli Infections : CK(66) : AC(39), Pseudomonas aeruginosa : CK(58) : AC(31), Staphylococcus aureus infection : CK(54) : AC(38), Ulcers : CK(6) : AC(3)
Pharmacological Actions : Anti-Bacterial Agents : CK(970) : AC(316), Anti-Ulcer Agents : CK(162) : AC(57)

Aspen bark extract has a protective effect against gastric peptic ulcer.

Pubmed Data : Eksp Klin Farmakol. 2000 Mar-Apr;63(2):44-7. PMID: 10834093
Article Published Date : Mar 01, 2000
Study Type : Animal Study
Additional Links
Substances : Aspen : CK(11) : AC(6)
Diseases : Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Aspen bark extract has a protective effect against gastric ulcer - Article 2.

Pubmed Data : Eksp Klin Farmakol. 1999 Jan-Feb;62(1):28-30. PMID: 10198761
Article Published Date : Jan 01, 1999
Study Type : Animal Study
Additional Links
Substances : Aspen : CK(11) : AC(6)
Diseases : Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Astaxanthin protects against gastric ulcer formation.

Pubmed Data : Phytother Res. 2011 Dec 14. Epub 2011 Dec 14. PMID: 22170791
Article Published Date : Dec 14, 2011
Study Type : Animal Study
Additional Links
Substances : Astaxanthin : CK(353) : AC(117)
Diseases : Alcohol Toxicity : CK(212) : AC(85), Aspirin-Induced Toxicity : CK(83) : AC(24), Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57), Gastroprotective : CK(62) : AC(31)

Baccharis dracunculifolia exhibits intestinal anti-inflammatory activity in a rat model of colitis.

Pubmed Data : Evid Based Complement Alternat Med. 2009 Jul 10. Epub 2009 Jul 10. PMID: 19592480
Article Published Date : Jul 10, 2009
Study Type : Animal Study
Additional Links
Substances : Baccharis dracunculifolia : CK(10) : AC(7)
Diseases : Colitis : CK(368) : AC(53)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Anti-Ulcer Agents : CK(162) : AC(57)

Baccharis dracunculifolia, the main botanical source of Brazilian green propolis, displays antiulcer activity.

Pubmed Data : J Pharm Pharmacol. 2007 Apr;59(4):603-8. PMID: 17430646
Article Published Date : Apr 01, 2007
Study Type : Animal Study
Additional Links
Substances : Baccharis dracunculifolia : CK(10) : AC(7), Bee Propolis : CK(220) : AC(83), Flavonoids : CK(909) : AC(289)
Diseases : Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57)
Additional Keywords : Natural Substances Versus Drugs : CK(988) : AC(165), Plant Extracts : CK(3572) : AC(1216)

Banana powder has anti-ulcerogenic properties.

Pubmed Data : J Ethnopharmacol. 1986 Oct;18(1):33-44. PMID: 3821133
Article Published Date : Oct 01, 1986
Study Type : Animal Study
Additional Links
Substances : Banana : CK(123) : AC(36)
Diseases : Aspirin-Induced Toxicity : CK(83) : AC(24), Corticosteroid-Induced Toxicity : CK(78) : AC(17), Duodenal Ulcer : CK(89) : AC(26), Gastric Ulcer : CK(246) : AC(91), NSAID-induced toxicity : CK(230) : AC(50)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57)

Bay leaf seeds have gastroprotective effects against ethanol induced gastric ulcer.

Pubmed Data : J Ethnopharmacol. 1997 Sep;58(1):9-14. PMID: 9323999
Article Published Date : Sep 01, 1997
Study Type : Animal Study
Additional Links
Substances : Bay leaf : CK(55) : AC(27)
Diseases : Alcohol Toxicity : CK(212) : AC(85), Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57), Gastroprotective : CK(62) : AC(31)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Bitter melon has anti-ulcer properties.

Pubmed Data : J Ethnopharmacol. 2009 Jun 25;123(3):464-9. Epub 2009 Mar 26. PMID: 19501279
Article Published Date : Jun 25, 2009
Study Type : Animal Study
Additional Links
Substances : Bitter Melon : CK(65) : AC(18)
Diseases : Duodenal Ulcer : CK(89) : AC(26), Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Butterbur's anti-leukotriene activity may be responsible for its beneficial effect on gastrointestinal ulcers

Pubmed Data : Planta Med. 1993 Dec;59(6):494-6. PMID: 8302945
Article Published Date : Dec 01, 1993
Study Type : Animal Study
Additional Links
Substances : Butterbur : CK(88) : AC(15)
Diseases : Duodenal Ulcer : CK(89) : AC(26), Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57), Leukotriene Antagonists : CK(38) : AC(9)

Cardamom has a gastroprotective effect in rats.

Pubmed Data : J Ethnopharmacol. 2006 Jan 16;103(2):149-53. Epub 2005 Nov 17. PMID: 16298093
Article Published Date : Jan 16, 2006
Study Type : Animal Study
Additional Links
Substances : Cardamom : CK(16) : AC(5)
Diseases : Alcohol Toxicity : CK(212) : AC(85), Aspirin-Induced Toxicity : CK(83) : AC(24), Gastric Ulcer : CK(246) : AC(91), NSAID-induced toxicity : CK(230) : AC(50)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57)

Celery extract significantly protects the gastric mucosa and suppresses the basal gastric secretion in rats, possibly through its antioxidant potential.

Pubmed Data : Pharm Biol. 2010 Jul ;48(7):786-93. PMID: 20645778
Article Published Date : Jul 01, 2010
Study Type : Animal Study
Additional Links
Substances : Celery : CK(30) : AC(12)
Diseases : Acid Reflux : CK(288) : AC(42), Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions : Acid Blockers : CK(40) : AC(16), Anti-Ulcer Agents : CK(162) : AC(57), Malondialdehyde Down-regulation : CK(76) : AC(21)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Comparative studies of standard drugs to treat antipeptic ulcer against leaf extract of Plantago lanceolata indicate that higher doses (400 mg/kg for mice; 280 mg/kg for rats) provided better overall protection than standard drugs.

Pubmed Data : Phytother Res. 2011 Aug ;25(8):1174-80. Epub 2011 Feb 7. PMID: 21298726
Article Published Date : Aug 01, 2011
Study Type : Animal Study
Additional Links
Substances : Plantago lanceolata : CK(2) : AC(1)
Diseases : Duodenal Ulcer : CK(89) : AC(26)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Costunolide, a component of Bay leaf, inhibits blood-ethanol elevation in rats.

Pubmed Data : Alcohol Alcohol. 2002 Mar-Apr;37(2):121-7. PMID: 11912066
Article Published Date : Mar 01, 2002
Study Type : Animal Study
Additional Links
Substances : Bay leaf : CK(55) : AC(27)
Diseases : Alcohol Toxicity : CK(212) : AC(85)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57), Enzyme Inhibitors : CK(372) : AC(208)

Curcumin compares favorably with bisdemethoxycurcumin in a gastric ulcer model system.

Pubmed Data : Phytomedicine. 2009 Apr;16(4):342-51. Epub 2009 Feb 1. PMID: 19188055
Article Published Date : Apr 01, 2009
Study Type : Animal Study
Additional Links
Substances : Bisdemethoxycurcumin : CK(5) : AC(2), Curcumin : CK(2910) : AC(1482)
Diseases : Gastric Ulcer : CK(246) : AC(91), Lipopolysaccharide-Induced Toxicity : CK(227) : AC(128)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57), Proton Pump Inhibitor : CK(36) : AC(13), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Curcumin has anti-ulcer activity in experimental gastric ulcer in rats.

Pubmed Data : Biomed Environ Sci. 2009 Dec;22(6):488-95. PMID: 20337222
Article Published Date : Dec 01, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Gastric Ulcer : CK(246) : AC(91), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57), Antioxidants : CK(3653) : AC(1318), Gastroprotective : CK(62) : AC(31), Interleukin-6 Downregulation : CK(470) : AC(135)

Curcumin reduces indomethacin-induced damage in the rat small intestine.

Pubmed Data : Cancer Res. 2010 Nov 15;70(22):9218-23. Epub 2010 Oct 26. PMID: 17351913
Article Published Date : Nov 15, 2010
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Duodenal Ulcer : CK(89) : AC(26), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57), Antioxidants : CK(3653) : AC(1318)
Additional Keywords : Drug: Indomethacin : CK(30) : AC(17)

Print Options

Some features are currently member only features. If you are already a member, please login. Otherwise, click here to become a member.