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Article Count - 275
Cumulative Knowledge - 524

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Quick Summary: Current access displays 2 out of 139 associated Substances

Name	Cumulative Knowledge	Article Count	Focus Articles
Sulforaphane	106	62	Log in \| Sign up
Curcumin	91	59	Log in \| Sign up

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View the Evidence: Pharmacological Actions

Evidence exists indicating that Brassica vegetables reduce prostate cancer risk.

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Pubmed Data : Nutr Cancer. 2002;42(1):1-9. PMID: 12235639

Article Published Date : Jan 01, 2002

Study Type : Meta Analysis

Additional Links

Substances : Bok Choy : CK(20) : AC(1), Broccoli : CK(449) : AC(185), Cabbage : CK(65) : AC(13), Collards : CK(53) : AC(6), Kale : CK(43) : AC(6), Mustard Greens : CK(39) : AC(12)

Diseases : Prostate Cancer: Prevention : CK(155) : AC(16)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275)

Additional Keywords : Risk Reduction : CK(1909) : AC(196)

A vitamin K2 preparation inhibits the development of liver cancer in patients with type C cirrhosis.

Click here to read the entire abstract

Pubmed Data : Hepatogastroenterology. 2010 Sep-Oct;57(102-103):1264-7. PMID: 21410069

Article Published Date : Sep 01, 2010

Study Type : Human Study

Additional Links

Substances : Menatetrenone : CK(10) : AC(1), Vitamin K2 : CK(277) : AC(32), Vitamin K2: Menaquinones (MK-4-14) : CK(149) : AC(19)

Diseases : Liver Cancer : CK(1641) : AC(266), Liver Cirrhosis : CK(216) : AC(32)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Hepatoprotective : CK(557) : AC(272)

Dietary intake of carotenoids reduce the risk of endometrial cancer.

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Pubmed Data : Cancer Causes Control. 2008 Dec;19(10):1209-15. Epub 2008 Jul 1. PMID: 18592384

Article Published Date : Dec 01, 2008

Study Type : Human Study

Additional Links

Substances : Carotenoids : CK(1055) : AC(213), Vitamin A : CK(371) : AC(58)

Diseases : Endometrial Cancer : CK(269) : AC(45)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Chemopreventive : CK(1528) : AC(382)

Additional Keywords : Risk Reduction : CK(1909) : AC(196)

Genistein and daidzein consumption are associated with a lower risk of prostate cancer.

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Pubmed Data : J Altern Complement Med. 2009 Aug;15(8):905-9. PMID: 19838933

Article Published Date : Aug 01, 2009

Study Type : Human Study

Additional Links

Substances : Daidzein : CK(965) : AC(28), Genistein : CK(450) : AC(174), Isoflavones : CK(627) : AC(124)

Diseases : Prostate Cancer: Prevention : CK(155) : AC(16)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Chemopreventive : CK(1528) : AC(382)

Additional Keywords : Risk Reduction : CK(1909) : AC(196)

Green tea polyphenols induce apoptosis in vitro in peripheral blood T lymphocytes of adult T-cell leukemia patients.

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Pubmed Data : Jpn J Cancer Res. 2000 Jan;91(1):34-40. PMID: 10744042

Article Published Date : Jan 01, 2000

Study Type : Human Study

Additional Links

Diseases : Adult T-cell leukemia/lymphoma (ATL) : CK(53) : AC(6)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Antiviral Agents : CK(613) : AC(280), Apoptotic : CK(1489) : AC(1114)

Healthy volunteers chewed broccoli sprouts exposed the glucosinolates to plant myrosinase and significantly increased dithiocarbamate excretion.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2001 May ;10(5):501-8. PMID: 11352861

Article Published Date : Apr 30, 2001

Study Type : Human Study

Additional Links

Substances : Broccoli Sprouts : CK(10) : AC(1)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275)

Additional Keywords : Isothiocyanates : CK(70) : AC(23)

Higher intake of lycopene, beta-carotene and beta-cryptoxanthin is associated to a lower risk of breast cancer among Chinese women.

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Pubmed Data : Asia Pac J Clin Nutr. 2007;16 Suppl 1:437-42. PMID: 17392146

Article Published Date : Jan 01, 2007

Study Type : Human Study

Additional Links

Substances : beta-Carotene : CK(217) : AC(38), Carotenoids : CK(1055) : AC(213), Cryptoxanthin : CK(36) : AC(8), Lycopene : CK(194) : AC(38)

Diseases : Breast Cancer: Prevention : CK(525) : AC(73)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275)

Additional Keywords : Risk Reduction : CK(1909) : AC(196)

Long-term supplementation with alpha-tocopherol (vitamin E) substantially reduced prostate cancer incidence and mortality in male smokers.

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Pubmed Data : J Natl Cancer Inst. 1998 Mar 18;90(6):440-6. PMID: 9521168

Article Published Date : Mar 18, 1998

Study Type : Human Study

Additional Links

Substances : Vitamin E : CK(1285) : AC(221)

Diseases : Prostate Cancer: Prevention : CK(155) : AC(16), Smoking : CK(577) : AC(86)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275)

Additional Keywords : Risk Reduction : CK(1909) : AC(196)

Oral silibinin, an IGF-1 binder, may result in lowered IGF-1 levels in liver and colorectal cancer patients as indicated by its accumulation in blood and tissue samples.

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Pubmed Data : Clin Cancer Res. 2006 May 1;12(9):2944-50. PMID: 16675592

Article Published Date : May 01, 2006

Study Type : Human Study

Additional Links

Substances : Milk Thistle : CK(226) : AC(55), Silibinin : CK(58) : AC(10), Silymarin : CK(36) : AC(8)

Diseases : Colorectal Cancer : CK(877) : AC(321), Liver Cancer : CK(1641) : AC(266)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Insulin-Like Growth Factor Inhibition/Downregulation : CK(66) : AC(16)

Raw broccoli results in faster absorption, higher bioavailability, and higher peak plasma amounts of sulforaphane, compared to cooked broccoli.

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Pubmed Data : J Agric Food Chem. 2008 Nov 26;56(22):10505-9. PMID: 18950181

Article Published Date : Nov 26, 2008

Study Type : Human Study

Additional Links

Substances : Broccoli : CK(449) : AC(185), Sulforaphane : CK(520) : AC(171)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275)

Additional Keywords : Raw versus Cooked : CK(69) : AC(13)

Safety Study: Brocolli sprouts (sulforaphane) are safe, tolerable and do not adversely effect thyroid hormone levels.

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Pubmed Data : Nutr Cancer. 2006;55(1):53-62. PMID: 16965241

Article Published Date : Jan 01, 2006

Study Type : Human Study

Additional Links

Substances : Broccoli : CK(449) : AC(185), Sprouts : CK(76) : AC(36), Sulforaphane : CK(520) : AC(171)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275)

Additional Keywords : Isothiocyanates : CK(70) : AC(23), Plant Extracts : CK(3572) : AC(1216)

Soy intake is associated with a small reduction in breast cancer risk.

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Pubmed Data : J Natl Cancer Inst. 2006 Apr 5;98(7):459-71. PMID: 16595782

Article Published Date : Apr 05, 2006

Study Type : Human Study

Additional Links

Substances : Soy : CK(1672) : AC(347)

Diseases : Breast Cancer: Prevention : CK(525) : AC(73)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Chemopreventive : CK(1528) : AC(382)

Additional Keywords : Risk Reduction : CK(1909) : AC(196)

The bioavailability of isothiocyanates from fresh broccoli is approximately three times greater than that from cooked broccoli,

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2000;38(2):168-78. PMID: 11525594

Article Published Date : Jan 01, 2000

Study Type : Human Study

Additional Links

Substances : Broccoli : CK(449) : AC(185), Sulforaphane : CK(520) : AC(171)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275)

Additional Keywords : Raw versus Cooked : CK(69) : AC(13)

Tomato sauce supplementation reduces prostate cancer growth in men.

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Pubmed Data : Exp Biol Med (Maywood). 2002 Nov;227(10):886-93. PMID: 12424330

Article Published Date : Nov 01, 2002

Study Type : Human Study

Additional Links

Substances : Carotenoids : CK(1055) : AC(213), Lycopene : CK(194) : AC(38), Tomato : CK(271) : AC(47)

Diseases : Prostate Cancer : CK(998) : AC(288)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Antioxidants : CK(3653) : AC(1318), Apoptotic : CK(1489) : AC(1114), Chemopreventive : CK(1528) : AC(382)

The addition of broccoli and watercress in the diet may reduce risk of breast cancer

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Pubmed Data : Toxicol Appl Pharmacol. 2005 Dec 1 ;209(2):105-13. Epub 2005 Jun 13. PMID: 15953625

Article Published Date : Dec 01, 2005

Study Type : Human In Vitro

Additional Links

Substances : Broccoli : CK(449) : AC(185), Sulforaphane : CK(520) : AC(171), Watercress : CK(14) : AC(4)

Diseases : Breast Cancer : CK(2354) : AC(621)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71)

Additional Keywords : Isothiocyanates : CK(70) : AC(23), Plant Extracts : CK(3572) : AC(1216)

"Chrysin abrogates early hepatocarcinogenesis and induces apoptosis in N-nitrosodiethylamine-induced preneoplastic nodules in rats."

Click here to read the entire abstract

Pubmed Data : Toxicol Appl Pharmacol. 2011 Feb 15 ;251(1):85-94. Epub 2010 Dec 15. PMID: 21167192

Article Published Date : Feb 15, 2011

Study Type : Animal Study

Additional Links

Substances : Flavonoids : CK(909) : AC(289)

Diseases : Liver Cancer: Prevention : CK(109) : AC(21)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Cyclooxygenase 2 Inhibitors : CK(269) : AC(169), Tumor Suppressor Protein p53 Upregulation : CK(146) : AC(105)

3,3'-Diindolylmethane inhibits angiogenesis and the growth of transplantable human breast carcinoma in athymic mice.

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Pubmed Data : Carcinogenesis. 2005 Apr;26(4):771-8. Epub 2005 Jan 20. PMID: 15661811

Article Published Date : Apr 01, 2005

Study Type : Animal Study

Additional Links

Substances : Cruciferous Vegetables : CK(622) : AC(232)

Diseases : Breast Cancer : CK(2354) : AC(621), Breast Cancer: Metastatic : CK(82) : AC(33)

Pharmacological Actions : Anti-Angiogenic : CK(143) : AC(101), Anticarcinogenic Agents : CK(521) : AC(275)

A cocoa-rich diet prevents azoxymethane-induced colonic preneoplastic lesions in rats by restraining oxidative stress and cell proliferation and inducing apoptosis.

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Pubmed Data : Mol Nutr Food Res. 2011 Dec ;55(12):1895-9. Epub 2011 Sep 23. PMID: 21953728

Article Published Date : Dec 01, 2011

Study Type : Animal Study

Additional Links

Diseases : Colon Cancer: Prevention : CK(25) : AC(1), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Chemopreventive : CK(1528) : AC(382)

A combination of curcumin and green tea catechins prevents dimethylhydrazine-induced colon carcinogenesis.

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Pubmed Data : Food Chem Toxicol. 2010 Jan;48(1):390-5. Epub 2009 Oct 25. PMID: 19861145

Article Published Date : Jan 01, 2010

Study Type : Animal Study

Additional Links

Substances : Catechin : CK(403) : AC(130), Curcumin : CK(2910) : AC(1482), Green Tea : CK(930) : AC(294)

Diseases : Colon Cancer : CK(895) : AC(233), Colorectal Cancer : CK(877) : AC(321)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Apoptotic : CK(1489) : AC(1114), Chemopreventive : CK(1528) : AC(382)

Additional Keywords : Drug Synergy : CK(327) : AC(147)

Andrographis may be more effective an anticancer agent than Doxorubicin in lymphoma.

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Pubmed Data : Mol Biol Rep. 2008 Dec;35(4):535-40. Epub 2007 Sep 5. PMID: 17805989

Article Published Date : Dec 01, 2008

Study Type : Animal Study

Additional Links

Substances : Andrographis : CK(81) : AC(35)

Diseases : Lymph Node Cancer : CK(4) : AC(2), Lymphoma : CK(209) : AC(69)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Antioxidants : CK(3653) : AC(1318)

Additional Keywords : Drug: Doxorubicin : CK(141) : AC(55), Plant Extracts : CK(3572) : AC(1216), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Astaxanthin inhibits mammary tumor growth more effectively than canthaxanthin and beta-carotene.

Click here to read the entire abstract

Pubmed Data : Anticancer Res. 1999 May-Jun;19(3A):1849-53. PMID: 10470126

Article Published Date : May 01, 1999

Study Type : Animal Study

Additional Links

Substances : Astaxanthin : CK(353) : AC(117)

Diseases : Breast Cancer : CK(2354) : AC(621), Lipid Peroxidation : CK(403) : AC(127)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Antioxidants : CK(3653) : AC(1318), Chemopreventive : CK(1528) : AC(382)

Benzyl isothiocyanate (BITC), a constituent of edible cruciferous vegetables, inhibits growth of human breast cancer cells in culture.

Click here to read the entire abstract

Pubmed Data : Cancer Res. 2009 Dec 15;69(24):9473-80. PMID: 19934325

Article Published Date : Dec 15, 2009

Study Type : Animal Study

Additional Links

Substances : Cruciferous Vegetables : CK(622) : AC(232)

Diseases : Breast Cancer : CK(2354) : AC(621), Breast Cancer: Prevention : CK(525) : AC(73)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275)

Beta-Cryptoxanthin and Hesperidin are potential cancer chemopreventive agents against tongue, colon, and lung cancers.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Biomed Biotechnol. 2012 ;2012:516981. Epub 2011 Nov 24. PMID: 22174562

Article Published Date : Jan 01, 2012

Study Type : Animal Study

Additional Links

Substances : Cryptoxanthin : CK(36) : AC(8), Hesperidin : CK(160) : AC(38), Orange: Mandarin : CK(6) : AC(2)

Diseases : Colon Cancer : CK(895) : AC(233), Inflammation : CK(1077) : AC(363), Lung Cancer : CK(496) : AC(198), Tongue Cancer : CK(14) : AC(10)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Chemopreventive : CK(1528) : AC(382)

Coffee's chemopreventive properties may be due to induction of cellular defenses and alteration of phase 1 detoxification enzymes.

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Pubmed Data : Food Chem Toxicol. 2008 Apr;46(4):1239-48. Epub 2007 Sep 26. PMID: 17976884

Article Published Date : Apr 01, 2008

Study Type : Animal Study

Additional Links

Substances : Coffee : CK(412) : AC(58)

Diseases : Cancers: All : CK(9062) : AC(2869)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Antioxidants : CK(3653) : AC(1318), Chemopreventive : CK(1528) : AC(382), Detoxifier : CK(306) : AC(101)

Consumption of some polyphenols reduces fecal deoxycholic acid and lithocholic acid, the secondary bile acids of risk factors of colon cancer.

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Pubmed Data : J Agric Food Chem. 2009 Sep 23;57(18):8587-90. PMID: 19711910

Article Published Date : Sep 23, 2009

Study Type : Animal Study

Additional Links

Substances : Caffeic Acid : CK(15) : AC(11), Curcumin : CK(2910) : AC(1482), Ellagic Acid : CK(77) : AC(40), Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174), Rutin : CK(93) : AC(30)

Diseases : Colon Cancer : CK(895) : AC(233)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275)

Health Guide: Cancer Research

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