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Additional Topics Details for this Page
Article Count
- 142
Cumulative Knowledge
- 669
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View the Evidence: Pharmacological Actions
Lowering cholesterol concentrations may increase mortality.
Click here to read the entire abstract
Pubmed Data
: BMJ. 1990 Aug 11 ;301(6747):309-14. PMID:
2144195
Article Published Date
: Aug 11, 1990
Study Type
: Meta Analysis
Additional Links
Substances
:
Cholesterol : CK(403) : AC(45)
Diseases
:
Mortality: All-Cause : CK(644) : AC(55)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances
:
Cholesterol Lowering Drugs : CK(2146) : AC(349)
Pravastatin therapy was associated with an increasing risk of cancer as age increases.
Click here to read the entire abstract
Pubmed Data
: CMAJ. 2007 Feb 27 ;176(5):649-54. PMID:
17325332
Article Published Date
: Feb 27, 2007
Study Type
: Meta Analysis
Additional Links
Diseases
:
Cancers: All : CK(9062) : AC(2869)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances
:
Pravastatin : CK(239) : AC(40)
Adverse Pharmacological Actions
:
Carcinogenic : CK(912) : AC(117)
Simvastatin contributes to insulin resistance in non-diabetic patients.
Click here to read the entire abstract
Pubmed Data
: Diabetes Res Clin Pract. 2010 Jan ;87(1):98-107. Epub 2009 Nov 12. PMID:
19913318
Article Published Date
: Jan 01, 2010
Study Type
: Meta Analysis
Additional Links
Diseases
:
Diabetes Mellitus: Type 2 : CK(3429) : AC(341)
,
Hyperglycemia : CK(2892) : AC(59)
,
Insulin Resistance : CK(1034) : AC(221)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances
:
Simvastatin : CK(713) : AC(143)
Adverse Pharmacological Actions
:
Diabetogenic : CK(166) : AC(14)
,
Endocrine Disruptor: Insulin Resistance : CK(152) : AC(31)
A diet high in plant sterols, vegetable proteins, viscous fibers and almonds is as effective as the statin drug lovastatin in managing hypercholesterolemia.
Click here to read the entire abstract
Pubmed Data
: JAMA. 2003 Jul 23;290(4):502-10. PMID:
12876093
Article Published Date
: Jul 23, 2003
Study Type
: Human Study
Additional Links
Substances
:
Almond : CK(107) : AC(15)
,
Fiber : CK(484) : AC(70)
,
Vegetables: All : CK(551) : AC(69)
Diseases
:
C-Reactive Protein : CK(819) : AC(74)
,
High Cholesterol : CK(1718) : AC(198)
,
Hyperlipidemia : CK(1211) : AC(109)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
Additional Keywords
:
Natural Substances Versus Drugs : CK(988) : AC(165)
A nut-enriched diet has cholesterol-lowering properties, and olive oil has a cholesterol-lowering property independent of its fatty acid content.
Click here to read the entire abstract
Pubmed Data
: Nutr Metab Cardiovasc Dis. 2011 Jun ;21 Suppl 1:S14-20. Epub 2011 Mar 21. PMID:
21421296
Article Published Date
: May 31, 2011
Study Type
: Human Study
Additional Links
Substances
:
Almond : CK(107) : AC(15)
,
Olive : CK(401) : AC(97)
,
Walnut : CK(163) : AC(26)
Diseases
:
Cardiovascular Diseases : CK(5138) : AC(641)
,
High Cholesterol : CK(1718) : AC(198)
,
Inflammation : CK(1077) : AC(363)
,
Lipid Peroxidation : CK(403) : AC(127)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
,
Cardioprotective : CK(702) : AC(196)
As an initial management strategy in patients with stable coronary artery disease, PCI did not reduce the risk of death, myocardial infarction, or other major cardiovascular events when added to optimal medical therapy.
Click here to read the entire abstract
Pubmed Data
: N Engl J Med. 2007 Apr 12;356(15):1503-16. Epub 2007 Mar 26. PMID:
17387127
Article Published Date
: Apr 12, 2007
Study Type
: Human Study
Additional Links
Diseases
:
Angioplasty : CK(32) : AC(5)
,
Coronary Artery Disease : CK(1305) : AC(136)
,
Myocardial Infarction : CK(2632) : AC(117)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
,
Antihypertensive Agents : CK(196) : AC(38)
,
Platelet Aggregation Inhibitors : CK(173) : AC(37)
Anti Therapeutic Actions
:
Angioplasty : CK(40) : AC(4)
Atorvastatin may cause nightmares.
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMJ. 2006 Apr 22 ;332(7547):950. PMID:
16627511
Article Published Date
: Apr 22, 2006
Study Type
: Human Study
Additional Links
Diseases
:
Nightmare : CK(13) : AC(2)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances
:
Atorvastatin : CK(491) : AC(90)
Atorvastatin worsens left ventricular diastolic function, which is improved through coenzyme q10 supplementation.
Click here to read the entire abstract
Pubmed Data
: Am J Cardiol. 2004 Nov 15 ;94(10):1306-10. PMID:
15541254
Article Published Date
: Nov 15, 2004
Study Type
: Human Study
Additional Links
Substances
:
Coenzyme Q10 : CK(667) : AC(104)
Diseases
:
Coenzyme Q10 Deficiency : CK(83) : AC(13)
,
Heart Failure : CK(711) : AC(97)
,
Hypertension : CK(2783) : AC(271)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
,
Antioxidants : CK(3653) : AC(1318)
Problem Substances
:
Atorvastatin : CK(491) : AC(90)
,
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Cardiotoxic : CK(638) : AC(79)
C-reactive protein more than LDL determines cardiovascular events and mortality in hemodialysis patients with type 2 diabetes mellitus.
Click here to read the entire abstract
Pubmed Data
: Am J Kidney Dis. 2009 Nov;54(5):902-11. Epub 2009 Sep 25. PMID:
19781835
Article Published Date
: Nov 01, 2009
Study Type
: Human Study
Additional Links
Diseases
:
C-Reactive Protein : CK(819) : AC(74)
,
Cholesterol: LDL/HDL ratio : CK(432) : AC(58)
,
Diabetes: Cardiovascular Illness : CK(666) : AC(104)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
Additional Keywords
:
C-Reactive Protein Versus Lipids : CK(10) : AC(1)
,
Cholesterol Myth : CK(136) : AC(18)
Daily consumption of a plant sterol-enriched soy drink significantly decreased total, non-HDL and LDL cholesterol.
Click here to read the entire abstract
Pubmed Data
: Taehan Kanho Hakhoe Chi. 2005 Feb;35(1):56-64. PMID:
18837970
Article Published Date
: Feb 01, 2005
Study Type
: Human Study
Additional Links
Substances
:
Phytosterols : CK(63) : AC(8)
Diseases
:
High Cholesterol : CK(1718) : AC(198)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
Exposure to atorvastatin is associated with lactone and acid metabolites that are increased several-fold in patients with atorvastatin-induced myopathy.
Click here to read the entire abstract
Pubmed Data
: Clin Pharmacol Ther. 2006 Jun ;79(6):532-9. PMID:
16765141
Article Published Date
: Jun 01, 2006
Study Type
: Human Study
Additional Links
Diseases
:
Myopathies : CK(252) : AC(51)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances
:
Atorvastatin : CK(491) : AC(90)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Flaxseed may reduce circulating total and LDL-cholesterol levels.
Click here to read the entire abstract
Pubmed Data
: Am J Clin Nutr. 2009 Aug;90(2):288-97. Epub 2009 Jun 10. PMID:
19515737
Article Published Date
: Aug 01, 2009
Study Type
: Human Study
Additional Links
Substances
:
Flaxseed : CK(275) : AC(57)
,
Lignans : CK(110) : AC(31)
Diseases
:
Cholesterol: LDL/HDL ratio : CK(432) : AC(58)
,
High Cholesterol : CK(1718) : AC(198)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
Grapefruit consumption may interefere with statin pharmokinetics.
Click here to read the entire abstract
Pubmed Data
: Br J Clin Pharmacol. 2004 Jul;58(1):56-60. PMID:
15206993
Article Published Date
: Jul 01, 2004
Study Type
: Human Study
Additional Links
Substances
:
Grapefruit : CK(109) : AC(30)
Diseases
:
Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances
:
Simvastatin : CK(713) : AC(143)
,
Statin Drugs : CK(3969) : AC(465)
L-Arginine enhances the triglyceride-lowering effect of simvastatin in patients with elevated plasma triglycerides.
Click here to read the entire abstract
Pubmed Data
: Nutr Res. 2009 May;29(5):291-7. PMID:
19555809
Article Published Date
: May 01, 2009
Study Type
: Human Study
Additional Links
Substances
:
Arginine : CK(970) : AC(169)
Diseases
:
Triglycerides: Elevated : CK(340) : AC(65)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
Additional Keywords
:
Drug Synergy : CK(327) : AC(147)
Lipid-lowering medication use is associated with increased aggression scores in women.
Click here to read the entire abstract
Pubmed Data
: J Womens Health (Larchmt). 2008 Mar ;17(2):187-94. PMID:
18321170
Article Published Date
: Mar 01, 2008
Study Type
: Human Study
Additional Links
Diseases
:
Aggression : CK(143) : AC(15)
,
Psychiatric Disorder: Aggression : CK(50) : AC(5)
,
Violence : CK(152) : AC(15)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances
:
Cholesterol Lowering Drugs : CK(2146) : AC(349)
Lovastatin may adversely affect neuropsychological tests of attention and psychomotor speed.
Click here to read the entire abstract
Pubmed Data
: Am J Med. 2000 May ;108(7):538-46. PMID:
10806282
Article Published Date
: May 01, 2000
Study Type
: Human Study
Additional Links
Diseases
:
Neuropsychological Dysfunction: Psychomotor Speed : CK(10) : AC(1)
,
Psychological Well-Being : CK(13) : AC(2)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances
:
Lovastatin : CK(265) : AC(67)
Adverse Pharmacological Actions
:
Neurotoxic : CK(1076) : AC(179)
Nattokinase combined with red yeast rice, but not nattokinase alone, has potent effects on blood lipids in human subjects with hyperlipidemia.
Click here to read the entire abstract
Pubmed Data
: Asia Pac J Clin Nutr. 2009;18(3):310-7. PMID:
19786378
Article Published Date
: Jan 01, 2009
Study Type
: Human Study
Additional Links
Substances
:
Nattokinase : CK(61) : AC(7)
,
Red Yeast Rice : CK(164) : AC(25)
Diseases
:
Hyperlipidemia : CK(1211) : AC(109)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
Additional Keywords
:
Natural Substance Synergy : CK(144) : AC(81)
Nineteen individuals administered 250 mg diatomaceous earth daily for 12 weeks experienced a significant decrease in total cholesterol, LDL, and triglycerides, while HDL values increased.
Click here to read the entire abstract
Pubmed Data
: Eur J Med Res. 1998 Apr 8 ;3(4):211-5. PMID:
9533930
Article Published Date
: Apr 08, 1998
Study Type
: Human Study
Additional Links
Substances
:
Diatomaceous earth : CK(10) : AC(1)
Diseases
:
High Cholesterol : CK(1718) : AC(198)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
Oat-containing cereal lowers total cholesterol in Hispanic americans.
Click here to read the entire abstract
Pubmed Data
: J Am Diet Assoc. 2005 Jun;105(6):967-70. PMID:
15942550
Article Published Date
: Jun 01, 2005
Study Type
: Human Study
Additional Links
Substances
:
Beta-glucan : CK(225) : AC(40)
,
Oats : CK(286) : AC(45)
Diseases
:
Cholesterol: LDL/HDL ratio : CK(432) : AC(58)
,
High Cholesterol : CK(1718) : AC(198)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
Patients who have low CRP levels after statin therapy have better clinical outcomes than those with higher CRP levels, regardless of the resultant level of LDL cholesterol.
Click here to read the entire abstract
Pubmed Data
: N Engl J Med. 2005 Jan 6;352(1):20-8. PMID:
15635109
Article Published Date
: Jan 06, 2005
Study Type
: Human Study
Additional Links
Diseases
:
C-Reactive Protein : CK(819) : AC(74)
,
Coronary Artery Disease : CK(1305) : AC(136)
,
Myocardial Infarction : CK(2632) : AC(117)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
Policosanol is superior to lovastatin and simvastatin in positively modulating blood lipid profiles.
Click here to read the entire abstract
Pubmed Data
: Rev Med Chil. 1999 Mar;127(3):286-94. PMID:
10436712
Article Published Date
: Mar 01, 1999
Study Type
: Human Study
Additional Links
Substances
:
Policosanol : CK(184) : AC(22)
Diseases
:
Cholesterol: LDL/HDL ratio : CK(432) : AC(58)
,
Hypercholesterolemia : CK(1517) : AC(165)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
Additional Keywords
:
Drug: Lovastatin : CK(10) : AC(1)
,
Drug: Simvastatin : CK(22) : AC(3)
,
Statin Alternatives : CK(34) : AC(4)
,
Superiority of Natural Substances versus Drugs : CK(826) : AC(164)
Psychiatric adverse reactions associated with cholesterol-lowering drugs have been reported.
Click here to read the entire abstract
Pubmed Data
: Drug Saf. 2007 ;30(3):195-201. PMID:
17343428
Article Published Date
: Jan 01, 2007
Study Type
: Human Study
Additional Links
Diseases
:
Aggression : CK(143) : AC(15)
,
Depression : CK(674) : AC(88)
,
Memory Disorders: Drug-Induced : CK(77) : AC(12)
,
Psychiatric Disorders : CK(71) : AC(10)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances
:
Fenofibrates : CK(133) : AC(19)
,
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Neurotoxic : CK(1076) : AC(179)
Psyllium has significant effect on serum total and LDL-cholesterol concentations in subjects consuming a low-fat diet.
Click here to read the entire abstract
Pubmed Data
: Am J Clin Nutr. 2000 Feb;71(2):472-9. PMID:
10648260
Article Published Date
: Feb 01, 2000
Study Type
: Human Study
Additional Links
Substances
:
Psyllium : CK(114) : AC(18)
Diseases
:
Cholesterol: High : CK(922) : AC(156)
,
Cholesterol: LDL/HDL ratio : CK(432) : AC(58)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
Severe irritability associated with statin cholesterol-lowering drugs has been reported.
Click here to read the entire abstract
Pubmed Data
: QJM. 2004 Apr ;97(4):229-35. PMID:
15028853
Article Published Date
: Apr 01, 2004
Study Type
: Human Study
Additional Links
Diseases
:
Aggression : CK(143) : AC(15)
,
Domestic Violence : CK(11) : AC(2)
,
Family Violence : CK(11) : AC(2)
,
Irritability : CK(10) : AC(1)
,
Psychiatric Disorders : CK(71) : AC(10)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
,
Violence : CK(152) : AC(15)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances
:
Statin Drugs : CK(3969) : AC(465)
Short-term cocoa consumption signficantly reduces blood cholesterol.
Click here to read the entire abstract
Pubmed Data
: Am J Clin Nutr. 2010 Jul;92(1):218-25. Epub 2010 May 26. PMID:
20504978
Article Published Date
: Jul 01, 2010
Study Type
: Human Study
Additional Links
Substances
:
Flavonoids : CK(909) : AC(289)
,
Polyphenols : CK(427) : AC(174)
Diseases
:
Cardiovascular Diseases : CK(5138) : AC(641)
,
High Cholesterol : CK(1718) : AC(198)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
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