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Article Count - 31
Cumulative Knowledge - 158

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View the Evidence: Pharmacological Actions

Meta-analysis: music listening is effective in reducing depressive symptoms in adults.

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Pubmed Data : Complement Ther Med. 2011 Dec ;19(6):332-48. Epub 2011 Sep 22. PMID: 22036525

Article Published Date : Dec 01, 2011

Study Type : Meta Analysis

Additional Links

Diseases : Depression : CK(674) : AC(88)

Therapeutic Actions : Music : CK(317) : AC(33)

Pharmacological Actions : Antidepressive Agents : CK(142) : AC(31)

'Drug' effects and placebo effects are not necessarily additive, and mutually exclusive mechanisms may be operating in the two arms.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Med Res Methodol. 2009 ;9:41. Epub 2009 Jun 23. PMID: 19549306

Article Published Date : Jan 01, 2009

Study Type : Human Study

Additional Links

Diseases : Anxiety Disorders : CK(659) : AC(82), Depression : CK(674) : AC(88)

Pharmacological Actions : Antidepressive Agents : CK(142) : AC(31)

Additional Keywords : Phytotherapy : CK(177) : AC(27), Plant Extracts : CK(3572) : AC(1216)

Among suicidal subjects who had ever used antidepressants, the current use of any antidepressant was associated with a markedly increased risk of attempted suicide and, at the same time, with a markedly decreased risk of completed suicide and death.

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Pubmed Data : Arch Gen Psychiatry. 2006 Dec ;63(12):1358-67. PMID: 17146010

Article Published Date : Nov 30, 2006

Study Type : Human Study

Additional Links

Diseases : Suicidal Behavior : CK(83) : AC(10), Suicidal Ideation : CK(11) : AC(2)

Pharmacological Actions : Antidepressive Agents : CK(142) : AC(31)

Problem Substances : Antidepressants : CK(245) : AC(33)

Both light and tryptophan have a therapeutic effect in the treatment of seasonal affective disorder.

Click here to read the entire abstract

Pubmed Data : J Affect Disord. 1998 Jul;50(1):23-7. PMID: 9716275

Article Published Date : Jul 01, 1998

Study Type : Human Study

Additional Links

Substances : Tryptophan : CK(322) : AC(30)

Diseases : Seasonal Affective Disorder : CK(60) : AC(6)

Therapeutic Actions : Light Therapy : CK(69) : AC(19)

Pharmacological Actions : Antidepressive Agents : CK(142) : AC(31)

Depression risk decreases with increasing caffeinated coffee consumption.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Arch Intern Med. 2011 Sep 26 ;171(17):1571-8. PMID: 21949167

Article Published Date : Sep 25, 2011

Study Type : Human Study

Additional Links

Substances : Coffee : CK(412) : AC(58)

Diseases : Depression : CK(674) : AC(88)

Pharmacological Actions : Antidepressive Agents : CK(142) : AC(31)

Kava is safe and effective in treating anxiety disorders and depression.

Click here to read the entire abstract

Pubmed Data : Psychopharmacology (Berl). 2009 Aug;205(3):399-407. Epub 2009 May 9. PMID: 19430766

Article Published Date : Aug 01, 2009

Study Type : Human Study

Additional Links

Substances : Kava Kava : CK(239) : AC(39)

Diseases : Anxiety Disorders : CK(659) : AC(82), Depression : CK(674) : AC(88)

Pharmacological Actions : Antidepressive Agents : CK(142) : AC(31), Anxiolytic : CK(268) : AC(41)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Motherwort improves symptoms of anxiety and depression in patients with arterial hypertension.

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Pubmed Data : Phytother Res. 2011 Apr;25(4):540-3. Epub 2010 Sep 13. PMID: 20839214

Article Published Date : Apr 01, 2011

Study Type : Human Study

Additional Links

Substances : Motherwort : CK(50) : AC(14)

Diseases : Anxiety Disorders : CK(659) : AC(82), Depression : CK(674) : AC(88), Hypertension : CK(2783) : AC(271)

Pharmacological Actions : Antidepressive Agents : CK(142) : AC(31), Anxiolytic : CK(268) : AC(41)

NAC appears a safe and effective augmentation strategy for depressive symptoms in bipolar disorder.

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Pubmed Data : Biol Psychiatry. 2008 Sep 15;64(6):468-75. Epub 2008 Jun 5. PMID: 18534556

Article Published Date : Sep 15, 2008

Study Type : Human Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine) : CK(264) : AC(62)

Diseases : Bipolar Disorder : CK(158) : AC(18)

Pharmacological Actions : Antidepressive Agents : CK(142) : AC(31)

Omega-3 polyunsaturated fatty acid supplementation is associated with reduced mania and depression in juvenile bipolar disorder.

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Pubmed Data : Eur J Clin Nutr. 2009 Aug;63(8):1037-40. Epub 2009 Jan 21. PMID: 19156158

Article Published Date : Aug 01, 2009

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid) : CK(582) : AC(100), EPA (Eicosapentaenoic Acid) : CK(595) : AC(84), Fish Oil : CK(615) : AC(95)

Diseases : Bipolar Disorder : CK(158) : AC(18)

Pharmacological Actions : Antidepressive Agents : CK(142) : AC(31)

THC appears therapeutic for anorexia and disturbed behavior in patients with Alzheimer's disease.

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Pubmed Data : Int J Geriatr Psychiatry. 1997 Sep ;12(9):913-9. PMID: 9309469

Article Published Date : Aug 31, 1997

Study Type : Human Study

Additional Links

Substances : Delta-tetrahydrocannabinol (THC) : CK(391) : AC(90)

Diseases : Anorexia: Dementia-Associated : CK(10) : AC(1)

Pharmacological Actions : Antidepressive Agents : CK(142) : AC(31)

"Antidepressant-like effect of trans-resveratrol in chronic stress model"

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Pubmed Data : J Psychiatr Res. 2012 Nov 19. Epub 2012 Nov 19. PMID: 23174668

Article Published Date : Nov 18, 2012

Study Type : Animal Study

Additional Links

Substances : Resveratrol : CK(977) : AC(590)

Diseases : Depression : CK(674) : AC(88)

Pharmacological Actions : Antidepressive Agents : CK(142) : AC(31)

Antidepressant-like effect of flaxseed secoisolariciresinol diglycoside in ovariectomized mice subjected to unpredictable chronic stress.

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Pubmed Data : Metab Brain Dis. 2012 Dec 22. Epub 2012 Dec 22. PMID: 23263992

Article Published Date : Dec 21, 2012

Study Type : Animal Study

Additional Links

Substances : Flaxseed : CK(275) : AC(57)

Diseases : Depression : CK(674) : AC(88), Ovariectomy Associated Adverse Changes : CK(18) : AC(7), Postmenopausal Disorder: Brain/Nervous System Pathology : CK(10) : AC(1)

Pharmacological Actions : Antidepressive Agents : CK(142) : AC(31)

Anti Therapeutic Actions : Stress : CK(30) : AC(9)

Bifidobacterium infantis ameliorates gut-brain axis dsyfunction in the maternal separation model of depression.

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Pubmed Data : Neuroscience. 2010 Nov 10;170(4):1179-88. Epub 2010 Aug 6. PMID: 20696216

Article Published Date : Nov 10, 2010

Study Type : Animal Study

Additional Links

Substances : Bifidobacterium Infantis : CK(53) : AC(7)

Diseases : Depression : CK(674) : AC(88), Gut Brain Axis: Imbalance : CK(22) : AC(9), Infant Problems: Maternal Separation : CK(6) : AC(3)

Pharmacological Actions : Antidepressive Agents : CK(142) : AC(31), Interleukin-6 Downregulation : CK(470) : AC(135)

Cocoa polyphenol has an antidepressant-like effect in rats.

Click here to read the entire abstract

Pubmed Data : Nutr Neurosci. 2008 Dec;11(6):269-76. PMID: 19000380

Article Published Date : Dec 01, 2008

Study Type : Animal Study

Additional Links

Substances : Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)

Diseases : Depression : CK(674) : AC(88)

Pharmacological Actions : Antidepressive Agents : CK(142) : AC(31)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Curcumin exhibits antidepressant properties.

Click here to read the entire abstract

Pubmed Data : Pharmacol Biochem Behav. 2005 Sep;82(1):200-6. PMID: 16171853

Article Published Date : Sep 01, 2005

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Depression : CK(674) : AC(88)

Pharmacological Actions : Antidepressive Agents : CK(142) : AC(31), Monoaminergic : CK(6) : AC(3)

Curcumin has antidepressant properties that compare favorably to the drugs imipramine and fluoxetine.

Click here to read the entire abstract

Pubmed Data : Acta Pol Pharm. 2011 Sep-Oct;68(5):769-75. PMID: 21928724

Article Published Date : Sep 01, 2011

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Depression : CK(674) : AC(88)

Pharmacological Actions : Antidepressive Agents : CK(142) : AC(31)

Additional Keywords : Drug: Fluoxetine : CK(12) : AC(2), Drug: Imipramine : CK(12) : AC(2), Natural Substances Versus Drugs : CK(988) : AC(165)

Curcumin has antidepressant-like effects in chronic unpredictable mild stress of rats.

Click here to read the entire abstract

Pubmed Data : Prog Neuropsychopharmacol Biol Psychiatry. 2009 Apr 30;33(3):435-49. Epub 2009 Jan 22. PMID: 19302828

Article Published Date : Apr 30, 2009

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Serotonin Disorders : CK(17) : AC(5), Stress : CK(434) : AC(60)

Pharmacological Actions : Antidepressive Agents : CK(142) : AC(31), Serotonin Agonists : CK(2) : AC(1)

Curcumin's antidepressant-like effects may involve the central monoaminergic neurotransmitter systems.

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2005 Jul 25;518(1):40-6. PMID: 15987635

Article Published Date : Jul 25, 2005

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Depression : CK(674) : AC(88)

Pharmacological Actions : Antidepressive Agents : CK(142) : AC(31), Monoaminergic : CK(6) : AC(3)

Fucoidan prevents depression-like behavior in rats exposed to repeated restraint stress.

Click here to read the entire abstract

Pubmed Data : J Nat Med. 2012 Oct 23. Epub 2012 Oct 23. PMID: 23090005

Article Published Date : Oct 22, 2012

Study Type : Animal Study

Additional Links

Substances : Fucoidan : CK(152) : AC(72)

Diseases : Depression: Restraint Stress Related : CK(2) : AC(1)

Pharmacological Actions : Antidepressive Agents : CK(142) : AC(31)

Lithium may reduce aluminium-induced cytotoxic effects in the rat brain.

Click here to read the entire abstract

Pubmed Data : Biometals. 2010 Apr;23(2):197-206. PMID: 19936942

Article Published Date : Apr 01, 2010

Study Type : Animal Study

Additional Links

Substances : Lithium : CK(31) : AC(8)

Diseases : Aluminum Toxicity : CK(100) : AC(36), DNA damage : CK(711) : AC(293)

Pharmacological Actions : Antidepressive Agents : CK(142) : AC(31), Neuroprotective Agents : CK(962) : AC(480)

Lobelia has antidepressant properties.

Click here to read the entire abstract

Pubmed Data : J Pharm Sci. 1992 Jul;81(7):620-1. PMID: 1403691

Article Published Date : Jul 01, 1992

Study Type : Animal Study

Additional Links

Substances : Lobelia : CK(8) : AC(5)

Diseases : Depression : CK(674) : AC(88)

Pharmacological Actions : Antidepressive Agents : CK(142) : AC(31)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Nutmeg demonstrates antidepressant activity.

Click here to read the entire abstract

Pubmed Data : J Med Food. 2006 Spring;9(1):84-9. PMID: 16579733

Article Published Date : Mar 01, 2006

Study Type : Animal Study

Additional Links

Substances : Nutmeg : CK(26) : AC(17)

Diseases : Depression : CK(674) : AC(88)

Pharmacological Actions : Adrenergic Agents : CK(2) : AC(1), Antidepressive Agents : CK(142) : AC(31), Dopaminergic : CK(32) : AC(10), Serotonergic : CK(32) : AC(8)

Panax ginseng extract exhibits antidepressant activity.

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2010 Jul 29. Epub 2010 Jul 29. PMID: 20673793

Article Published Date : Jul 29, 2010

Study Type : Animal Study

Additional Links

Substances : Panax Ginseng : CK(49) : AC(21)

Diseases : Depression : CK(674) : AC(88)

Pharmacological Actions : Antidepressive Agents : CK(142) : AC(31)

Piperine can relieve depression in rats by modulating the function of HPA axis.

Click here to read the entire abstract

Pubmed Data : Zhong Xi Yi Jie He Xue Bao. 2009 Jul;7(7):667-70. PMID: 19615322

Article Published Date : Jul 01, 2009

Study Type : Animal Study

Additional Links

Substances : Piperine : CK(29) : AC(14)

Diseases : Depression : CK(674) : AC(88), HPA Axis Dysregulation : CK(71) : AC(11)

Pharmacological Actions : Antidepressive Agents : CK(142) : AC(31), Neuroprotective Agents : CK(962) : AC(480)

Pomegranate improves depressive symptoms and bone properties in a menopausal syndrome model due to its estrogen content (estradiol, estrone and estriol).

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2004 May;92(1):93-101. PMID: 15099854

Article Published Date : May 01, 2004

Study Type : Animal Study

Additional Links

Substances : Pomegranate : CK(146) : AC(61)

Diseases : Estrogen Deficiency : CK(57) : AC(19), Menopausal Syndrome : CK(171) : AC(27), Osteoporosis : CK(1171) : AC(205)

Pharmacological Actions : Antidepressive Agents : CK(142) : AC(31)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Health Guide: Mental Health

Related Blogs

23 Natural Alternatives for Depression

Written by Pat Robinson

Kava is safe and effective in treating anxiety disorders and depression. L-tryptophan is as effective as imipramine in treating depression. Saffron may be of therapeutic benefit in the treatment of mild to moderate depression and has similar efficacy as the drug imipramine. St. John's Wort is as effective as Selective Serotoin Reuptake Inhibitors (SSRI) in the treatment of Depressive Disorder, with a greater safety rating.

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