Antiproliferative

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View the Evidence: Pharmacological Actions

Lycopene inhibits liver cancer cell growth.

Pubmed Data : Biofactors. 2005 ;23(3):129-39. PMID: 16410635
Article Published Date : Jan 01, 2005
Study Type : Meta Analysis
Additional Links
Substances : Lycopene : CK(194) : AC(38)
Diseases : Liver Cancer : CK(1641) : AC(266)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Antiproliferative : CK(1052) : AC(775), Cell cycle arrest : CK(390) : AC(319)

Chinese motherwort has cytotoxicity against human breast cancer cells that is non-apoptic and estrogen receptor independent.

Pubmed Data : J Ethnopharmacol. 2009 Mar 18;122(2):234-9. PMID: 19330917
Article Published Date : Mar 18, 2009
Study Type : Human Study
Additional Links
Substances : Motherwort : CK(50) : AC(14)
Diseases : Breast Cancer : CK(2354) : AC(621)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Curcumin selectively induces programmed cell death in cutaneous T-cell lymphoma cell lines and in peripheral blood mononuclear cells (PBMCs).

Pubmed Data : J Invest Dermatol. 2010 Aug;130(8):2110-9. Epub 2010 Apr 15. PMID: 20393484
Article Published Date : Aug 01, 2010
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : T-Cell Lymphoma: Cutaneous : CK(10) : AC(1)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), NF-kappaB Inhibitor : CK(595) : AC(401)

Curcumin suppresses of phosphorylase kinase activity which is correlated to a resolution of psoriasis.

Pubmed Data : Br J Dermatol. 2000 Nov;143(5):937-49. PMID: 11069500
Article Published Date : Nov 01, 2000
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Psoriasis : CK(270) : AC(42)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Dermatologic Agents : CK(124) : AC(13), Enzyme Inhibitors : CK(372) : AC(208), Phosphorylase Kinase Inhibitors : CK(10) : AC(1)

Green tea drinkers with susceptible IGF1 (CA)19/(CA)19 and (CA)19/X genotypes had a significant reduced risk of lung cancer.

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2012 ;7(2):e30951. Epub 2012 Feb 7. PMID: 22347413
Article Published Date : Jan 01, 2012
Study Type : Human Study
Additional Links
Substances : Green Tea : CK(930) : AC(294), Polyphenols : CK(427) : AC(174)
Diseases : Lung Cancer: Prevention : CK(20) : AC(1)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Chemopreventive : CK(1528) : AC(382)
Additional Keywords : Risk Reduction : CK(1909) : AC(196)
Problem Substances : Tobacco: Smoking : CK(125) : AC(12)

HLA-DQ2/8 genes may not cause gluten-associated villous atrophy, rather, be activated as a consequence of the pathological process.

Pubmed Data : Clin Chem Lab Med. 2005 ;43(7):685-95. PMID: 16207126
Article Published Date : Dec 31, 2004
Study Type : Human Study
Additional Links
Diseases : Celiac Disease : CK(1527) : AC(215)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114)
Additional Keywords : HLA-DQ2/DQ8 : CK(24) : AC(5), Questions Of Causality : CK(10) : AC(1)

Hyperbaric oxygen therapy may be an appropriate therapeutic regimen for the treatment of patients with osteosarcoma.

Pubmed Data : Oncol Rep. 2009 Nov;22(5):1045-50. PMID: 19787219
Article Published Date : Nov 01, 2009
Study Type : Human Study
Additional Links
Diseases : Osteosarcoma : CK(80) : AC(39)
Therapeutic Actions : Hyperbaric Treatment : CK(297) : AC(32)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114)
Additional Keywords : Drug Synergy : CK(327) : AC(147)

N-acetylcysteine compares favorably to metformin on mammographic density in postmenopausal women.

Pubmed Data : Vopr Onkol. 2012 ;58(1):45-9. PMID: 22629827
Article Published Date : Dec 31, 2011
Study Type : Human Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine) : CK(264) : AC(62)
Diseases : Breast: Mammographic Density : CK(10) : AC(1), Breast Cancer : CK(2354) : AC(621)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Hypoglycemic Agents : CK(563) : AC(156)
Additional Keywords : Drug: Metformin : CK(195) : AC(23), Natural Substances Versus Drugs : CK(988) : AC(165)

Resveratrol reduces tumor cell proliferation in colorectal patients.

Pubmed Data : Antiviral Res. 2008 Feb;77(2):153-6. Epub 2007 Oct 8. PMID: 20841478
Article Published Date : Feb 01, 2008
Study Type : Human Study
Additional Links
Substances : Resveratrol : CK(977) : AC(590)
Diseases : Colorectal Cancer : CK(877) : AC(321)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775)
Additional Keywords : Stilbenes : CK(402) : AC(242)

Lovastatin exhibits toxicity in human fetal brain cells.

Pubmed Data : Neurotoxicol Teratol. 1995 Jan-Feb;17(1):31-9. PMID: 7708017
Article Published Date : Jan 01, 1995
Study Type : Human In Vitro
Additional Links
Diseases : Abortion: Spontaneous : CK(204) : AC(29), Birth Defects : CK(196) : AC(37), Neurotoxicity : CK(37) : AC(15), Prenatal Chemical Exposures : CK(322) : AC(86)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775)
Problem Substances : Lovastatin : CK(265) : AC(67)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179), Teratogenic : CK(304) : AC(59)

Panaxadiol and Epigallocatechin Gallate have a synergistic apoptotic effect on human colorectal cancer cells.

Pubmed Data : Phytother Res. 2012 May 8. Epub 2012 May 8. PMID: 22566066
Article Published Date : May 08, 2012
Study Type : Human In Vitro
Additional Links
Substances : Catechin : CK(403) : AC(130), EGCG (Epigallocatechin gallate) : CK(859) : AC(109), Ginseng : CK(339) : AC(113), Green Tea : CK(930) : AC(294), Panaxadiol : CK(5) : AC(1)
Diseases : Colorectal Cancer : CK(877) : AC(321)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Chemosensitizer : CK(197) : AC(159)
Additional Keywords : Natural Substance Synergy : CK(144) : AC(81)

This study compares Boswellia sacra essential oil hydrodistilled at 100 °C vs 78 °C in inducing cancer cell death in cultured breast cancer cells; the oil prepared at 100 °C was more potent in inducing breast cancer cell-specific cytotoxicity.

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2011 ;11:129. Epub 2011 Dec 15. PMID: 22171782
Article Published Date : Dec 31, 2010
Study Type : Human In Vitro
Additional Links
Substances : Frankincense : CK(22) : AC(1)
Diseases : Breast Cancer : CK(2354) : AC(621), Cancer Metastasis : CK(272) : AC(135)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)
Additional Keywords : Selective Cytotoxicity : CK(58) : AC(41)

Pepper spray induced conjunctival proliferation, serious enough to require surgical excision, has been reported.

Pubmed Data : Cornea. 2011 Sep ;30(9):1042-4. PMID: 21642850
Article Published Date : Sep 01, 2011
Study Type : Human: Case Report
Additional Links
Diseases : Conjunctival Diseases : CK(15) : AC(5)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)
Anti Therapeutic Actions : Pepper Spraying : CK(85) : AC(11)
Problem Substances : Pepper Spray : CK(85) : AC(11)

"Chrysin abrogates early hepatocarcinogenesis and induces apoptosis in N-nitrosodiethylamine-induced preneoplastic nodules in rats."

Pubmed Data : Toxicol Appl Pharmacol. 2011 Feb 15 ;251(1):85-94. Epub 2010 Dec 15. PMID: 21167192
Article Published Date : Feb 15, 2011
Study Type : Animal Study
Additional Links
Substances : Flavonoids : CK(909) : AC(289)
Diseases : Liver Cancer: Prevention : CK(109) : AC(21)
Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Cyclooxygenase 2 Inhibitors : CK(269) : AC(169), Tumor Suppressor Protein p53 Upregulation : CK(146) : AC(105)

"Nitrite-generated NO circumvents dysregulated arginine/NOS signaling to protect against intimal hyperplasia in Sprague-Dawley rats."

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Invest. 2011 Apr ;121(4):1646-56. Epub 2011 Mar 23. PMID: 21436585
Article Published Date : Apr 01, 2011
Study Type : Animal Study
Additional Links
Substances : Arginine : CK(970) : AC(169), Nitrite : CK(2) : AC(1)
Diseases : Endothelial Dysfunction : CK(897) : AC(173)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Nitric Oxide Enhancer : CK(149) : AC(37)

"Propionyl-L-carnitine improves postischemic blood flow recovery and arteriogenetic revascularization."

Pubmed Data : Arterioscler Thromb Vasc Biol. 2010 Mar ;30(3):426-35. Epub 2010 Jan 7. PMID: 20056909
Article Published Date : Mar 01, 2010
Study Type : Animal Study
Additional Links
Substances : Carnitine : CK(672) : AC(69)
Diseases : Endothelial Dysfunction : CK(897) : AC(173), Heart Attack: Recovery : CK(22) : AC(3)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Vascular Endothelial Growth Factor A Inhibitor : CK(102) : AC(58)
Additional Keywords : Revascularization
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115)

"Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice."

Pubmed Data : Oncol Rep. 2011 Sep ;26(3):603-8. Epub 2011 May 20. PMID: 21617865
Article Published Date : Sep 01, 2011
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane : CK(520) : AC(171)
Diseases : Breast Cancer : CK(2354) : AC(621)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114)

"Thiamine supplementation attenuated hepatocellular carcinoma in the Atp7b mouse model of Wilson's disease."

Pubmed Data : Anticancer Res. 2011 Oct ;31(10):3395-9. PMID: 21965752
Article Published Date : Oct 01, 2011
Study Type : Animal Study
Additional Links
Substances : Thiamine (B-1) : CK(102) : AC(15)
Diseases : Liver Cancer: Wilson's Disease Induced : CK(2) : AC(1)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114)

A cocoa-rich diet prevents azoxymethane-induced colonic preneoplastic lesions in rats by restraining oxidative stress and cell proliferation and inducing apoptosis.

Pubmed Data : Mol Nutr Food Res. 2011 Dec ;55(12):1895-9. Epub 2011 Sep 23. PMID: 21953728
Article Published Date : Dec 01, 2011
Study Type : Animal Study
Additional Links
Diseases : Colon Cancer: Prevention : CK(25) : AC(1), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Chemopreventive : CK(1528) : AC(382)

A diet containing an isoflavone-poor soy protein concentrate may inhibit breast tumor progression and metastasis development.

Pubmed Data : Mol Nutr Food Res. 2008 Oct;52(10):1121-9. PMID: 18655005
Article Published Date : Oct 01, 2008
Study Type : Animal Study
Additional Links
Substances : Isoflavones : CK(627) : AC(124), Soy Protein : CK(2307) : AC(56)
Diseases : Breast Cancer : CK(2354) : AC(621), Breast Cancer: Metastatic : CK(82) : AC(33)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775)

A gamma-tocopherol-rich mixture of tocopherols inhibits colon, prostate, mammary, and lung tumorigenesis in animal models.

Pubmed Data : Carcinogenesis. 2009 Sep 11. Epub 2009 Sep 11. PMID: 19748925
Article Published Date : Sep 11, 2009
Study Type : Animal Study
Additional Links
Substances : Vitamin E: Gamma-Tocopherol : CK(2) : AC(1)
Diseases : Cancers: All : CK(9062) : AC(2869)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Chemopreventive : CK(1528) : AC(382)

A mixture containing ascorbic acid, lysine, proline and green tea extract inhibits angiogenesis of tumor cells.

Pubmed Data : Carcinogenesis. 2006 Dec;27(12):2424-33. Epub 2006 Jun 19. PMID: 16142336
Article Published Date : Dec 01, 2006
Study Type : Animal Study
Additional Links
Substances : Green Tea : CK(930) : AC(294), Lysine : CK(99) : AC(21), Proline : CK(19) : AC(8), Vitamin C : CK(1274) : AC(238)
Diseases : Cancer Metastasis : CK(272) : AC(135), Tumors : CK(197) : AC(110)
Pharmacological Actions : Anti-metastatic : CK(192) : AC(115), Antiproliferative : CK(1052) : AC(775), Vascular Endothelial Growth Factor A Inhibitor : CK(102) : AC(58)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

A red yeast rice extract inhibits the proliferation of colorectal cancer cells.

Pubmed Data : J Med Food. 2008 Mar;11(1):91-8. PMID: 20356949
Article Published Date : Mar 01, 2008
Study Type : Animal Study
Additional Links
Substances : Red Yeast Rice : CK(164) : AC(25)
Diseases : Cancer Metastasis : CK(272) : AC(135), Colorectal Cancer : CK(877) : AC(321)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

A selenium/arginine mixture prevents chemically-induced immunosuppresion and accelerated aging.

Pubmed Data : Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2007 Dec;23(12):1126-9. PMID: 18062883
Article Published Date : Dec 01, 2007
Study Type : Animal Study
Additional Links
Substances : Arginine : CK(970) : AC(169), Selenium : CK(574) : AC(94)
Diseases : Aging : CK(1351) : AC(369), Aging: Immunosenecence : CK(52) : AC(11), Immune Disorders: Low Immune Function : CK(488) : AC(115)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Immunomodulatory : CK(536) : AC(142)

A Western-style diet induced pancreatic epithelial cell hyperproliferation in mice, further suggesting that increased fat content and decreased calcium and vitamin D contribute to the development of pancreatic neoplasms.

Pubmed Data : J Natl Cancer Inst. 1996 Nov 6;88(21):1586-90. PMID: 8901857
Article Published Date : Nov 06, 1996
Study Type : Animal Study
Additional Links
Substances : Calcium : CK(232) : AC(35), Vitamin D : CK(1682) : AC(238)
Diseases : Pancreatic Cancer : CK(530) : AC(168)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775)
Anti Therapeutic Actions : Western Diet : CK(86) : AC(24)

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