Apoptotic

Apoptotic

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View the Evidence: Pharmacological Actions

THC, the active metabolite of cannabis induces programmed cell death in Jurkat leukemia T Cells.

Pubmed Data : Mol Cancer Res. 2006 Aug;4(8):549-62 PMID: 16908594
Article Published Date : Aug 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Marihuana : CK(727) : AC(139)
Diseases : Acute T cell Leukemias : CK(11) : AC(11)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114)

THC, the active metabolite of cannabis potently induces programmed cell death in leukemic cell lines.

Pubmed Data : BMC Immunol. 2009;10:12. Epub 2009 Feb 20. PMID: 15454482
Article Published Date : Jan 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Marihuana : CK(727) : AC(139)
Diseases : Leukemia : CK(670) : AC(258)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114)

The anti-breast cancer activity of curcumin may be due in part to its down-regulation of insulin-like growth factor.

Pubmed Data : Life Sci. 2007 May 16;80(23):2161-9. Epub 2007 Apr 21. PMID: 17499312
Article Published Date : May 16, 2007
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Breast Cancer : CK(2354) : AC(621), Insulin-like Growth Factor (IGF): Elevated : CK(33) : AC(6)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319), Insulin-Like Growth Factor Inhibition/Downregulation : CK(66) : AC(16)
Additional Keywords : Drug Synergy : CK(327) : AC(147)

The anti-cancer activity of sulforphane may be related to inhibition of interleukin-6 and transcription 3 in prostate cancer cells.

Pubmed Data : Cancer Prev Res (Phila). 2010 Apr;3(4):484-94. Epub 2010 Mar 16. PMID: 20233902
Article Published Date : Apr 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane : CK(520) : AC(171)
Diseases : Prostate Cancer : CK(998) : AC(288)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Apoptotic : CK(1489) : AC(1114), Interleukin-6 Downregulation : CK(470) : AC(135)
Additional Keywords : Isothiocyanates : CK(70) : AC(23), Plant Extracts : CK(3572) : AC(1216)

The apple polyphenol phloretin potentiates the anticancer actions of paclitaxel against human hepatoma cells.

Pubmed Data : Mol Carcinog. 2009 May;48(5):420-31. PMID: 18767070
Article Published Date : May 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Apples : CK(179) : AC(57), Phloretin : CK(4) : AC(4), Polyphenols : CK(427) : AC(174)
Diseases : Hepatoma : CK(38) : AC(33)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114)
Additional Keywords : Drug-Plant-Vitamin Synergies : CK(1011) : AC(268)

The bioactive compounds alpha-chaconine and gallic acid in potato extracts decrease survival and induce apoptosis in prostate cancer cells.

Pubmed Data : Nutr Cancer. 2010 Jul;62(5):601-10. PMID: 20574921
Article Published Date : Jul 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Potato : CK(71) : AC(31)
Diseases : Prostate Cancer : CK(998) : AC(288)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114)

The combination of vitamin D with genistein results in an enhanced inhibition of lipid accumulation and induction of programmed cell death in maturing preadipocytes (immature fat cells).

Pubmed Data : Life Sci. 2002 Oct 4;71(20):2383-90. PMID: 18239559
Article Published Date : Oct 04, 2002
Study Type : In Vitro Study
Additional Links
Substances : Genistein : CK(450) : AC(174), Vitamin D : CK(1682) : AC(238)
Diseases : Abdominal Obesity (Midsection Fat) : CK(348) : AC(53), Obesity : CK(1849) : AC(275)
Pharmacological Actions : Anti-Adipogenic : CK(87) : AC(44), Apoptotic : CK(1489) : AC(1114)
Additional Keywords : Natural Substance Synergy : CK(144) : AC(81)

The dietary flavonoids ECGC, luteolin, quercetin, kaempferol, apigenin, and taxifolin inhibit cancer cell lipogenesis.

Pubmed Data : J Biol Chem. 2005 Feb 18;280(7):5636-45. Epub 2004 Nov 8. PMID: 15533929
Article Published Date : Feb 18, 2005
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(859) : AC(109), Flavonoids : CK(909) : AC(289), Kaempferol : CK(27) : AC(22), Luteolin : CK(62) : AC(51), Polyphenols : CK(427) : AC(174), Quercetin : CK(318) : AC(136), Taxifolin : CK(1) : AC(1)
Diseases : Cancers: All : CK(9062) : AC(2869)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114)

The dietary flavonoids luteolin, apigenin, chrysin and naringenin (found in fruits and vegetables) are potent natural proteasome inhibotrs and tumor cell death inducers.

Pubmed Data : Front Biosci. 2007;12:1935-45. Epub 2007 Jan 1. PMID: 17127432
Article Published Date : Jan 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Apigenin : CK(76) : AC(51), Chrysin : CK(15) : AC(12), Flavonoids : CK(909) : AC(289), Fruit: All : CK(1836) : AC(472), Luteolin : CK(62) : AC(51), Naringenin : CK(17) : AC(12), Vegetables: All : CK(551) : AC(69)
Diseases : Cancers: All : CK(9062) : AC(2869), Tumors : CK(197) : AC(110)
Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Apoptotic : CK(1489) : AC(1114), Chemopreventive : CK(1528) : AC(382), Proteasome Inhibitors : CK(41) : AC(27)

The dietary polyphenol quercetin targets pancreatic cancer stem cells.

Pubmed Data : Int J Oncol. 2010 Sep ;37(3):551-61. PMID: 20664924
Article Published Date : Sep 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Quercetin : CK(318) : AC(136)
Diseases : Cancer Stem Cells : CK(988) : AC(42), Pancreatic Cancer : CK(530) : AC(168)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114)
Additional Keywords : Cancer Stem Cells : CK(30) : AC(24), Drug Synergy : CK(327) : AC(147)

The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells

Pubmed Data : Int J Oncol. 2010 Jul;37(1):187-93. PMID: 20514410
Article Published Date : Jul 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Anandamide : CK(2) : AC(2)
Diseases : Colon Cancer : CK(895) : AC(233)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114)
Additional Keywords : Endocannabinoid System : CK(1) : AC(1), Endogenous Cannabinoid : CK(1) : AC(1)

The flavonoids apigenin, EGCG and genistein selectively induce programmed cell death in glioblastoma cells.

Pubmed Data : Cancer. 2010 Jan 1;116(1):164-76. PMID: 19894226
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Apigenin : CK(76) : AC(51), EGCG (Epigallocatechin gallate) : CK(859) : AC(109), Flavonoids : CK(909) : AC(289), Genistein : CK(450) : AC(174)
Diseases : Glioblastoma : CK(46) : AC(20)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114)
Additional Keywords : Selective Cytotoxicity : CK(58) : AC(41)

The food-derived polyphenols quercetin, trans-resveratrol and genistein inhibit pancreatic cancer growth and prevent metastasis, in vitro.

Pubmed Data : Int J Cancer. 2002 Apr 10;98(5):761-9. PMID: 11920648
Article Published Date : Apr 10, 2002
Study Type : In Vitro Study
Additional Links
Substances : Genistein : CK(450) : AC(174), Polyphenols : CK(427) : AC(174), Quercetin : CK(318) : AC(136), Resveratrol : CK(977) : AC(590)
Diseases : Pancreatic Cancer : CK(530) : AC(168)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114)
Additional Keywords : Natural Substance Synergy : CK(144) : AC(81)

The green tea polyphenol EGCG enhances the anti-cancer activity of bortezomib in multiple myeloma cells.

Pubmed Data : Acta Biochim Biophys Sin (Shanghai). 2009 Dec;41(12):1018-26. PMID: 20011976
Article Published Date : Dec 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Catechin : CK(403) : AC(130), Tea : CK(989) : AC(234)
Diseases : Multiple Myeloma : CK(156) : AC(53)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Apoptotic : CK(1489) : AC(1114), Caspase-3 Activation : CK(23) : AC(15), Caspase-9 Activation : CK(5) : AC(5), Chemosensitizer : CK(197) : AC(159)
Additional Keywords : Drug: Bortezomib : CK(3) : AC(3), Drug Synergy : CK(327) : AC(147)

The isoflavones biochanin A and genistein inhibit the cell growth of stomach cancer lines by inducing programmed cell death.

Pubmed Data : Cancer Res. 1993 Dec 1;53(23):5815-21. PMID: 8242641
Article Published Date : Dec 01, 1993
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A : CK(9) : AC(8), Genistein : CK(450) : AC(174), Isoflavones : CK(627) : AC(124)
Diseases : Stomach Cancer : CK(373) : AC(20)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114)

The mushroom Phellinus Linteus induces programmed cell death and arrests growth in human lung cancer cells.

Pubmed Data : Mol Carcinog. 2007 Feb;46(2):144-54. PMID: 17131292
Article Published Date : Feb 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Phellinus Linteus : CK(6) : AC(4)
Diseases : Lung Cancer : CK(496) : AC(198)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)
Additional Keywords : Drug: Doxorubicin : CK(141) : AC(55)

The natural Nuclear factor-kappaB inhibitor curcumin may help to overcome drug resistance in human pancreatic cancer.

Pubmed Data : Mol Cancer Ther. 2006 Sep;5(9):2251-60. PMID: 16985059
Article Published Date : Sep 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Cancers: Drug Resistant : CK(225) : AC(147), Pancreatic Cancer : CK(530) : AC(168)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), NF-kappaB Inhibitor : CK(595) : AC(401)
Additional Keywords : Drug Synergy : CK(327) : AC(147)

The phytoestrogens quercetin, baicalein, genistein, epigallocatechin gallate (EGCG), and curcumin are effective inhibitors of prostate tumor cell growth.

Pubmed Data : Nutr Cancer. 2004;49(2):200-8. PMID: 15489213
Article Published Date : Jan 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Baicalein : CK(7) : AC(6), Catechin : CK(403) : AC(130), Curcumin : CK(2910) : AC(1482), phytoestrogens : CK(699) : AC(210), Quercetin : CK(318) : AC(136), Resveratrol : CK(977) : AC(590)
Diseases : Prostate Cancer : CK(998) : AC(288)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)
Additional Keywords : Stilbenes : CK(402) : AC(242)

The plant polyphenols curcumin, carnosic acid, and silibinin may work synergistically to inhibit acute myeloid leukemia cells.

Pubmed Data : Nutr Cancer. 2010 Aug;62(6):811-24. PMID: 20661831
Article Published Date : Aug 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Carsonic Acid : CK(2) : AC(2), Curcumin : CK(2910) : AC(1482), Milk Thistle : CK(226) : AC(55), Silibinin : CK(58) : AC(10)
Diseases : Leukemia: Acute myelogenous leukemia (AML) : CK(96) : AC(28), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114)
Additional Keywords : Natural Substance Synergy : CK(144) : AC(81), Plant Extracts : CK(3572) : AC(1216)

The soy isoflavones genistein and genistin demonstrate cytotoxicity against ovarian cancer cells.

Pubmed Data : Life Sci. 2007 Mar 20;80(15):1403-8. Epub 2007 Jan 19. PMID: 17291540
Article Published Date : Mar 20, 2007
Study Type : In Vitro Study
Additional Links
Substances : Genistein : CK(450) : AC(174), Isoflavones : CK(627) : AC(124), Soy : CK(1672) : AC(347)
Diseases : Ovarian Cancer : CK(154) : AC(58)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)

The Tabebuia tree bark compound beta-lapachone induces growth inhibition and programmed cell death in bladder cancer cells.

Pubmed Data : Exp Oncol. 2006 Mar;28(1):30-5 PMID: 16614704
Article Published Date : Mar 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Tabebuia : CK(10) : AC(9)
Diseases : Bladder Cancer : CK(186) : AC(60)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114)

Theaflavins from black tea selectively inhibit SV40-transformed cancer cells.

Pubmed Data : Cancer Res. 2000 Nov 15;60(22):6465-71. PMID: 11103814
Article Published Date : Nov 15, 2000
Study Type : In Vitro Study
Additional Links
Substances : Black Tea : CK(158) : AC(40), Catechin : CK(403) : AC(130), Theaflavins : CK(1) : AC(1)
Diseases : Cancers: All : CK(9062) : AC(2869), Simian virus 40 (SV40) : CK(7) : AC(5)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Cyclooxygenase 2 Inhibitors : CK(269) : AC(169)
Additional Keywords : Selective Cytotoxicity : CK(58) : AC(41)

Tocotrienols induce programmed cell death in breast cancer cell lines.

Pubmed Data : Breast Cancer Res Treat. 2010 Feb 16. Epub 2010 Feb 16. PMID: 20157774
Article Published Date : Feb 16, 2010
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienols : CK(22) : AC(16)
Diseases : Breast Cancer : CK(2354) : AC(621)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114)

Tocotrienols inhibit growth and induce programmed cell death in human cervical cancer cells.

Pubmed Data : Integr Cancer Ther. 2010 Feb 11. Epub 2010 Feb 11. PMID: 20150225
Article Published Date : Feb 11, 2010
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienols : CK(22) : AC(16)
Diseases : Cervical Cancer : CK(363) : AC(69)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Interleukin-6 upregulation : CK(26) : AC(7)

Tongkat Ali exerts anti-proliferative action and growth inhibition on breast cancer cells.

Pubmed Data : Anticancer Res. 2007 Sep-Oct;27(5A):3425-30. PMID: 17970090
Article Published Date : Sep 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Tongkat Ali : CK(7) : AC(5)
Diseases : Breast Cancer : CK(2354) : AC(621)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114)

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