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Aromatase Inhibitors

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Article Count - 23
Cumulative Knowledge - 35

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Quick Summary: Current access displays 2 out of 28 associated Substances

Name	Cumulative Knowledge	Article Count	Focus Articles
Astaxanthin	10	1	Log in \| Sign up
Saw Palmetto	10	1	Log in \| Sign up

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View the Evidence: Pharmacological Actions

A dietary supplement containing astaxanthin and saw palmetto berry extract decrease dihydrotestosterone, increase testosterone and decrease estradiol levels in healthy males.

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Pubmed Data : J Cardiovasc Electrophysiol. 2009 Sep;20(9):1055-60. Epub 2009 Apr 30. PMID: 18700016

Article Published Date : Sep 01, 2009

Study Type : Human Study

Additional Links

Substances : Astaxanthin : CK(353) : AC(117), Saw Palmetto : CK(82) : AC(17)

Diseases : Low Testosterone : CK(385) : AC(70), Male Hormone Imbalances : CK(14) : AC(3), Testosterone: Too Low : CK(369) : AC(70)

Pharmacological Actions : Aromatase Inhibitors : CK(33) : AC(23)

Additional Keywords : DHT Blocker : CK(10) : AC(1)

Grapeseed inhibits aromatase activity in an animal model of mammary cancer.

Click here to read the entire abstract

Pubmed Data : Cancer Res. 2006 Jun 1;66(11):5960-7. PMID: 16740737

Article Published Date : Jun 01, 2006

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract : CK(168) : AC(57)

Diseases : Breast Cancer : CK(2354) : AC(621)

Pharmacological Actions : Aromatase Inhibitors : CK(33) : AC(23)

"Melatonin suppresses aromatase expression and activity in breast cancer associated fibroblasts."

Click here to read the entire abstract

Pubmed Data : Breast Cancer Res Treat. 2012 Apr ;132(2):765-71. Epub 2012 Jan 12. PMID: 22237979

Article Published Date : Mar 31, 2012

Study Type : In Vitro Study

Additional Links

Substances : Melatonin : CK(470) : AC(131)

Diseases : Breast Cancer : CK(2354) : AC(621)

Pharmacological Actions : Aromatase Inhibitors : CK(33) : AC(23)

Damiana contains compounds with anti-aromatase activity.

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol.2008 Dec 8;120(3):387-93. Epub 2008 Sep 26. PMID: 18948180

Article Published Date : Dec 08, 2008

Study Type : In Vitro Study

Additional Links

Substances : Damiana : CK(4) : AC(6)

Diseases : Estrogen Dominance : CK(106) : AC(37)

Pharmacological Actions : Aromatase Inhibitors : CK(33) : AC(23)

Euonymus altaus and Scutellaria barbarata have prowerful aromatase inhibiting properties.

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Pubmed Data : Immunopharmacol Immunotoxicol. 2004 Aug;26(3):315-27. PMID: 15518167

Article Published Date : Aug 01, 2004

Study Type : In Vitro Study

Additional Links

Substances : Euonymus alatus (Burning Bush) : CK(2) : AC(2), Sculletaria barbata : CK(12) : AC(4)

Diseases : Estrogen Dominance : CK(106) : AC(37)

Pharmacological Actions : Aromatase Inhibitors : CK(33) : AC(23)

Hops contains compounds which inhibit the aromatase enzyme and estrogen formation, inducing apoptosis in breast cancer cells.

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Pubmed Data : J Steroid Biochem Mol Biol. 2007 Jun-Jul;105(1-5):124-30. Epub 2007 Jul 23. PMID: 17643984

Article Published Date : Jun 01, 2007

Study Type : In Vitro Study

Additional Links

Substances : Hops : CK(51) : AC(20)

Diseases : Breast Cancer : CK(2354) : AC(621)

Pharmacological Actions : Aromatase Inhibitors : CK(33) : AC(23)

Hops rich beer contains flavonoids which inhibit extrogen formation in choriocarcinoma-derived cells.

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Pubmed Data : J Agric Food Chem. 2006 Apr 19;54(8):2938-43. PMID: 16608212

Article Published Date : Apr 19, 2006

Study Type : In Vitro Study

Additional Links

Substances : Beer : CK(37) : AC(8), Hops : CK(51) : AC(20)

Diseases : Choriocarcinoma : CK(4) : AC(4), Trophoblastic Neoplasms : CK(3) : AC(3), Trophoblastic Tumor : CK(3) : AC(3)

Pharmacological Actions : Aromatase Inhibitors : CK(33) : AC(23)

Licorice contains a compound (liquiritigenin) with aromatase inhibitory action 10 times more potent than the first generation aromatase inhibitor aminoglutethimide (Cytadren).

Click here to read the entire abstract

Pubmed Data : Bioorg Med Chem. 2008 Sep 15;16(18):8466-70. Epub 2008 Aug 19. PMID: 18778944

Article Published Date : Sep 15, 2008

Study Type : In Vitro Study

Additional Links

Substances : Licorice : CK(257) : AC(81)

Diseases : Estrogen Dominance : CK(106) : AC(37)

Pharmacological Actions : Aromatase Inhibitors : CK(33) : AC(23)

Additional Keywords : Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Lignans and flavonoids act as aromatase inhibitors in human preadipocytes.

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Pubmed Data : J Steroid Biochem Mol Biol. 1994 Aug;50(3-4):205-12. PMID: 8049151

Article Published Date : Aug 01, 1994

Study Type : In Vitro Study

Additional Links

Substances : Enterodiol : CK(34) : AC(12), Flavonoids : CK(909) : AC(289), Lignans : CK(110) : AC(31)

Diseases : Breast Cancer : CK(2354) : AC(621), Estrogen Dominance : CK(106) : AC(37)

Pharmacological Actions : Aromatase Inhibitors : CK(33) : AC(23)

Mace contains compounds which exhibit antiproliferative, anti-aromatse and anti-17beta-hydroxysteroid dehydrogenase activity.

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Pubmed Data : Planta Med. 2001 Nov;67(8):700-4. PMID: 11731908

Article Published Date : Nov 01, 2001

Study Type : In Vitro Study

Additional Links

Substances : Maca : CK(80) : AC(21)

Pharmacological Actions : 17beta-hydroxysteroid dehydrogenase inhibitor : CK(1) : AC(1), Antiproliferative : CK(1052) : AC(775), Aromatase Inhibitors : CK(33) : AC(23)

Mammalian lignans and the soy isoflavone genistein inhibit breast cancer via down-regulation of estrogen production.

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Pubmed Data : J Steroid Biochem Mol Biol. 2005 Apr;94(5):461-7. Epub 2005 Mar 16. PMID: 15876411

Article Published Date : Apr 01, 2005

Study Type : In Vitro Study

Additional Links

Substances : Enterodiol : CK(34) : AC(12), Enterolactone : CK(301) : AC(10), Genistein : CK(450) : AC(174), Lignans : CK(110) : AC(31)

Diseases : Breast Cancer : CK(2354) : AC(621), Estrogen Dominance : CK(106) : AC(37)

Pharmacological Actions : Aromatase Inhibitors : CK(33) : AC(23)

Mangosteen contains xanthones with aromatase inhibitory activity.

Click here to read the entire abstract

Pubmed Data : J Nat Prod. 2008 Jul;71(7):1161-6. Epub 2008 Jun 18. PMID: 18558747

Article Published Date : Jul 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Mangosteen : CK(42) : AC(20)

Diseases : Estrogen Dominance : CK(106) : AC(37)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Aromatase Inhibitors : CK(33) : AC(23)

Additional Keywords : Xanthones : CK(50) : AC(28)

Melatonin could stimulate the differentiation of fibroblasts and reduce the aromatase activity and expression in both fibroblasts and adipocytes, thereby reducing the number of estrogen-producing cells proximal to malignant cells.

Click here to read the entire abstract

Pubmed Data : J Pineal Res. 2012 Jan ;52(1):12-20. Epub 2011 Jul 1. PMID: 21718362

Article Published Date : Dec 31, 2011

Study Type : In Vitro Study

Additional Links

Substances : Melatonin : CK(470) : AC(131)

Diseases : Breast Cancer : CK(2354) : AC(621)

Pharmacological Actions : Aromatase Inhibitors : CK(33) : AC(23), Cell Differentiation Inducer : CK(6) : AC(5)

Melatonin down-regulates estrogen production in endothelial cells via its anti-aromatase activity.

Click here to read the entire abstract

Pubmed Data : Oncol Rep. 2013 Feb 28. Epub 2013 Feb 28. PMID: 23450505

Article Published Date : Feb 27, 2013

Study Type : In Vitro Study

Additional Links

Substances : Melatonin : CK(470) : AC(131)

Diseases : Breast Cancer : CK(2354) : AC(621), Breast Cancer: Estrogen : CK(5) : AC(2), Breast Cancer: estrogen receptor alpha-positive : CK(3) : AC(2)

Pharmacological Actions : Aromatase Inhibitors : CK(33) : AC(23)

Pomegranate compounds exhibit antiproliferative and antiaromatase activity in breast cancer cells in vitro.

Click here to read the entire abstract

Pubmed Data : Cancer Prev Res (Phila Pa). 2010 Jan;3(1):108-13. PMID: 20051378

Article Published Date : Jan 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Pomegranate : CK(146) : AC(61)

Diseases : Breast Cancer : CK(2354) : AC(621), Breast Cancer: Prevention : CK(525) : AC(73)

Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Aromatase Inhibitors : CK(33) : AC(23)

Pomegranate has potent anti-aromatase activity warranting its use for human breast cancer.

Click here to read the entire abstract

Pubmed Data : Breast Cancer Res Treat. 2002 Feb;71(3):203-17. PMID: 12002340

Article Published Date : Feb 01, 2002

Study Type : In Vitro Study

Additional Links

Substances : Pomegranate : CK(146) : AC(61)

Diseases : Breast Cancer : CK(2354) : AC(621)

Pharmacological Actions : Aromatase Inhibitors : CK(33) : AC(23)

Procyandidin from Red Wine and Grape Seeds inhibit androgen-dependant breast cancer turmors by reducing estrogen formation.

Click here to read the entire abstract

Pubmed Data : Cancer Res. 2003 Dec 1;63(23):8516-22. PMID: 14679019

Article Published Date : Dec 01, 2003

Study Type : In Vitro Study

Additional Links

Substances : Grape Seed Extract : CK(168) : AC(57), Red Wine Extract : CK(59) : AC(25)

Diseases : Breast Cancer : CK(2354) : AC(621)

Pharmacological Actions : Aromatase Inhibitors : CK(33) : AC(23)

Red clover demonstrates aromatase inhibition activity, which may reduce the risk of estrogen receptor positive breast cancer.

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Pubmed Data : Br J Nutr. 2008 Feb;99(2):303-10. Epub 2007 Aug 29. PMID: 17761019

Article Published Date : Feb 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Biochanin A : CK(9) : AC(8), Red Clover : CK(36) : AC(9)

Diseases : Breast Cancer : CK(2354) : AC(621)

Pharmacological Actions : Aromatase Inhibitors : CK(33) : AC(23)

Red wine extract has anti-aromatase activity which abrogates hyperpasia in mammary tissue.

Click here to read the entire abstract

Pubmed Data : Breast Cancer Res Treat. 2001 May;67(2):133-46. PMID: 11519862

Article Published Date : May 01, 2001

Study Type : In Vitro Study

Additional Links

Substances : Red Wine Extract : CK(59) : AC(25)

Diseases : Breast Cancer : CK(2354) : AC(621)

Pharmacological Actions : Aromatase Inhibitors : CK(33) : AC(23)

Resveratrol is a bilevel inhibitor of aromatase in breast cancer cells.

Click here to read the entire abstract

Pubmed Data : Toxicol Sci. 2006 Jul;92(1):71-7. Epub 2006 Apr 11. PMID: 16611627

Article Published Date : Jul 01, 2006

Study Type : In Vitro Study

Additional Links

Substances : Resveratrol : CK(977) : AC(590)

Diseases : Breast Cancer : CK(2354) : AC(621)

Pharmacological Actions : Aromatase Inhibitors : CK(33) : AC(23)

The licorice flavonoid isoliquiritgenein inhibits aromatase and is a potential chemopreventive agent in breast cancer.

Click here to read the entire abstract

Pubmed Data : Int J Cancer. 2009 Mar 1;124(5):1028-36. PMID: 19065667

Article Published Date : Mar 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Licorice : CK(257) : AC(81)

Diseases : Breast Cancer : CK(2354) : AC(621)

Pharmacological Actions : Aromatase Inhibitors : CK(33) : AC(23)

The mammalian phytoestrogens enterodiol and enterolactone may protect against breast and prostate cancer through hormone modulating activities.

Click here to read the entire abstract

Pubmed Data : J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Sep 25;777(1-2):289-309. PMID: 12270221

Article Published Date : Sep 25, 2002

Study Type : Review

Additional Links

Substances : Enterodiol : CK(34) : AC(12), Enterolactone : CK(301) : AC(10), Flaxseed : CK(275) : AC(57), Lignans : CK(110) : AC(31), phytoestrogens : CK(699) : AC(210), Secoisolariciresinol diglucoside (SDG) : CK(387) : AC(5)

Diseases : Breast Cancer : CK(2354) : AC(621), Cancers: All : CK(9062) : AC(2869), Prostate Cancer : CK(998) : AC(288)

Pharmacological Actions : Aromatase Inhibitors : CK(33) : AC(23)

White button mushrooms have anti-aromatase activity and may provide an idea breast cancer chemopreventive agent. Article 1

Click here to read the entire abstract

Pubmed Data : Mol Cell Biochem. 2005 Dec;280(1-2):173-9. PMID: 17178902

Article Published Date : Dec 01, 2005

Study Type : In Vitro Study

Additional Links

Substances : White Button Mushroom : CK(16) : AC(11)

Diseases : Breast Cancer : CK(2354) : AC(621)

Pharmacological Actions : Aromatase Inhibitors : CK(33) : AC(23)

White button mushrooms have anti-aromatase activity and may provide an ideal breast cancer chemopreventive agent. - Article 2

Click here to read the entire abstract

Pubmed Data : J Nutr. 2001 Dec;131(12):3288-93. PMID: 11739882

Article Published Date : Dec 01, 2001

Study Type : In Vitro Study

Additional Links

Substances : White Button Mushroom : CK(16) : AC(11)

Diseases : Breast Cancer : CK(2354) : AC(621)

Pharmacological Actions : Aromatase Inhibitors : CK(33) : AC(23)

Yerba mate contains a potent aromatase inhibitor.

Click here to read the entire abstract

Pubmed Data : Eur J Med Chem. 2008 Sep;43(9):1865-77. Epub 2007 Dec 7. PMID: 18192087

Article Published Date : Sep 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Yerba Mate : CK(11) : AC(4)

Diseases : Estrogen Dominance : CK(106) : AC(37)

Pharmacological Actions : Aromatase Inhibitors : CK(33) : AC(23)

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