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Bcl-2 protein down-regulation
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Additional Topics Details for this Page
Article Count
- 38
Cumulative Knowledge
- 52
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View the Evidence: Pharmacological Actions
Folic acid protects motor neurons against the increased homocysteine, inflammation and programmed cell death.
Click here to read the entire abstract
Pubmed Data
: Neuropharmacology. 2008 Jun;54(7):1112-9. Epub 2008 Mar 16. PMID:
18436268
Article Published Date
: Jun 01, 2008
Study Type
: In Vitro Study
Additional Links
Diseases
:
Amyotrophic Lateral Sclerosis : CK(350) : AC(68)
,
Inflammation : CK(1077) : AC(363)
Pharmacological Actions
:
Anti-Apoptotic : CK(59) : AC(39)
,
Bcl-2 protein down-regulation : CK(49) : AC(38)
,
Neuroprotective Agents : CK(962) : AC(480)
,
Nitric Oxide Inhibitor : CK(108) : AC(57)
,
Superoxide Dismutase Up-regulation : CK(131) : AC(42)
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)
Fucoidan has antiproliferative effects in human gastric cancer cell lines.
Click here to read the entire abstract
Pubmed Data
: J Food Sci. 2011 Apr ;76(3):T77-83. PMID:
21535865
Article Published Date
: Mar 31, 2011
Study Type
: In Vitro Study
Additional Links
Substances
:
Fucoidan : CK(152) : AC(72)
Diseases
:
Gastric Cancer : CK(373) : AC(111)
Pharmacological Actions
:
Antineoplastic Agents : CK(877) : AC(496)
,
Antiproliferative : CK(1052) : AC(775)
,
Apoptotic : CK(1489) : AC(1114)
,
Autophagy Up-regulation : CK(18) : AC(13)
,
Bcl-2 protein down-regulation : CK(49) : AC(38)
Fucoidan present in brown algae induces apoptosis of human colon cancer cells.
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Gastroenterol. 2010 ;10:96. Epub 2010 Aug 22. PMID:
20727207
Article Published Date
: Dec 31, 2009
Study Type
: In Vitro Study
Additional Links
Substances
:
Fucoidan : CK(152) : AC(72)
Diseases
:
Colon Cancer : CK(895) : AC(233)
Pharmacological Actions
:
Antineoplastic Agents : CK(877) : AC(496)
,
Antiproliferative : CK(1052) : AC(775)
,
Apoptotic : CK(1489) : AC(1114)
,
Bcl-2 protein down-regulation : CK(49) : AC(38)
Additional Keywords
:
Phytotherapy : CK(177) : AC(27)
,
Plant Extracts : CK(3572) : AC(1216)
Gallic acid extracted from the leaves of Phyllanthus emblica exhibits anti-cancer activity against liver cancer.
Click here to read the entire abstract
Pubmed Data
: Zhong Yao Cai. 2011 Feb ;34(2):246-9. PMID:
21823485
Article Published Date
: Feb 01, 2011
Study Type
: In Vitro Study
Additional Links
Substances
:
Gallic Acid : CK(26) : AC(13)
,
Phyllanthus emblica : CK(8) : AC(5)
Diseases
:
Liver Cancer : CK(1641) : AC(266)
Pharmacological Actions
:
Apoptotic : CK(1489) : AC(1114)
,
Bcl-2 protein down-regulation : CK(49) : AC(38)
,
Cell cycle arrest : CK(390) : AC(319)
,
Chemopreventive : CK(1528) : AC(382)
Genistein inhibits triple-negative breast cancer cell growth.
Click here to read the entire abstract
Pubmed Data
: Int J Mol Med. 2012 Aug ;30(2):337-43. Epub 2012 May 9. PMID:
22580499
Article Published Date
: Jul 31, 2012
Study Type
: In Vitro Study
Additional Links
Substances
:
Genistein : CK(450) : AC(174)
Diseases
:
Breast Cancer: Triple Negative : CK(61) : AC(13)
Pharmacological Actions
:
Apoptotic : CK(1489) : AC(1114)
,
Bcl-2 protein down-regulation : CK(49) : AC(38)
,
Bcl-xL down-regulation : CK(1) : AC(1)
,
Chemopreventive : CK(1528) : AC(382)
,
NF-kappaB Inhibitor : CK(595) : AC(401)
Helenalin, a compound found within Arnica, may have a role as an immunosuppressive compound suited for the treatment of deregulated and unwanted T cell-mediated immune responses.
Click here to read the entire abstract
Pubmed Data
: Mol Immunol. 2009 Sep;46(15):2892-901. Epub 2009 Aug 5. PMID:
19656571
Article Published Date
: Sep 01, 2009
Study Type
: In Vitro Study
Additional Links
Substances
:
Arnica : CK(146) : AC(23)
,
Helenalin : CK(3) : AC(3)
Diseases
:
Immune Dysregulation: TH1/TH2 imbalance : CK(146) : AC(36)
Pharmacological Actions
:
Antiproliferative : CK(1052) : AC(775)
,
Apoptotic : CK(1489) : AC(1114)
,
Bcl-2 protein down-regulation : CK(49) : AC(38)
,
Immunosuppressive Agents : CK(26) : AC(19)
,
NF-kappaB Inhibitor : CK(595) : AC(401)
,
Proteasome Inhibitors : CK(41) : AC(27)
,
Tumor Suppressor Protein p53 Upregulation : CK(146) : AC(105)
Hyperforin induces apoptosis of chronic lymphocytic leukemia cells.
Click here to read the entire abstract
Pubmed Data
: Int J Oncol. 2012 Jan ;40(1):269-76. Epub 2011 Sep 22. PMID:
21947285
Article Published Date
: Dec 31, 2011
Study Type
: In Vitro Study
Additional Links
Substances
:
Hyperforin : CK(1) : AC(1)
Diseases
:
Chronic Lymphocytic Leukemia : CK(56) : AC(27)
Pharmacological Actions
:
Apoptotic : CK(1489) : AC(1114)
,
Bcl-2 protein down-regulation : CK(49) : AC(38)
Melatonin has anti-angiogenic properties.
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2006 Nov;41(4):358-62. PMID:
17014693
Article Published Date
: Nov 01, 2006
Study Type
: In Vitro Study
Additional Links
Substances
:
Melatonin : CK(470) : AC(131)
Diseases
:
Cancer Metastasis : CK(272) : AC(135)
,
Tumors : CK(197) : AC(110)
Pharmacological Actions
:
Anti-Angiogenic : CK(143) : AC(101)
,
Anti-metastatic : CK(192) : AC(115)
,
Antiproliferative : CK(1052) : AC(775)
,
Bcl-2 protein down-regulation : CK(49) : AC(38)
,
Tumor Suppressor Protein p53 Upregulation : CK(146) : AC(105)
Melatonin has radiosensitizing properties in leukemia cells and radioprotective properties in normal cells.
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2009 Sep;47(2):147-55. Epub 2009 Jun 23. PMID:
19555448
Article Published Date
: Sep 01, 2009
Study Type
: In Vitro Study
Additional Links
Substances
:
Melatonin : CK(470) : AC(131)
Diseases
:
Acute T cell Leukemias : CK(11) : AC(11)
Pharmacological Actions
:
Apoptotic : CK(1489) : AC(1114)
,
Bcl-2 protein down-regulation : CK(49) : AC(38)
,
Radioprotective : CK(456) : AC(183)
,
Radiosensitizer : CK(50) : AC(29)
,
Tumor Suppressor Protein p53 Upregulation : CK(146) : AC(105)
Melatonin induces programmed cell death in human breast cancer cells.
Click here to read the entire abstract
Pubmed Data
: Arch Facial Plast Surg. 2006 Jan-Feb;8(1):54-9. PMID:
12071473
Article Published Date
: Jan 01, 2006
Study Type
: In Vitro Study
Additional Links
Substances
:
Melatonin : CK(470) : AC(131)
Diseases
:
Breast Cancer : CK(2354) : AC(621)
Pharmacological Actions
:
Antiproliferative : CK(1052) : AC(775)
,
Apoptotic : CK(1489) : AC(1114)
,
Bcl-2 protein down-regulation : CK(49) : AC(38)
,
Cell cycle arrest : CK(390) : AC(319)
,
Tumor Suppressor Protein p53 Upregulation : CK(146) : AC(105)
Molecular mechanisms of celery seed extract induced cell death in human stomach cancer cells.
Click here to read the entire abstract
Pubmed Data
: Asian Pac J Cancer Prev. 2011 ;12(10):2601-6. PMID:
22320960
Article Published Date
: Dec 31, 2010
Study Type
: In Vitro Study
Additional Links
Substances
:
Celery seed : CK(20) : AC(7)
Diseases
:
Gastric Cancer : CK(373) : AC(111)
,
Stomach Cancer : CK(373) : AC(20)
Pharmacological Actions
:
Antiproliferative : CK(1052) : AC(775)
,
Apoptotic : CK(1489) : AC(1114)
,
Bcl-2 protein down-regulation : CK(49) : AC(38)
,
Cell cycle arrest : CK(390) : AC(319)
Additional Keywords
:
Plant Extracts : CK(3572) : AC(1216)
Pterostilbene has cytotoxic, anti-proliferative and antioxidant properties relevant to the treatment of breast and prostate cancer.
Click here to read the entire abstract
Pubmed Data
: Toxicol In Vitro. 2010 Jun;24(4):1215-28. Epub 2010 Feb 10. PMID:
20152895
Article Published Date
: Jun 01, 2010
Study Type
: In Vitro Study
Additional Links
Substances
:
Pterostilbene : CK(1011) : AC(29)
Diseases
:
Breast Cancer : CK(2354) : AC(621)
,
Prostate Cancer : CK(998) : AC(288)
Pharmacological Actions
:
Antioxidants : CK(3653) : AC(1318)
,
Antiproliferative : CK(1052) : AC(775)
,
Apoptotic : CK(1489) : AC(1114)
,
Bcl-2 protein down-regulation : CK(49) : AC(38)
,
Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71)
Additional Keywords
:
Stilbenes : CK(402) : AC(242)
Quercetin exhibits an inhibitory effect in a human hepatoma cell line.
Click here to read the entire abstract
Pubmed Data
: J Nutr. 2006 Nov ;136(11):2715-21. PMID:
17056790
Article Published Date
: Nov 01, 2006
Study Type
: In Vitro Study
Additional Links
Substances
:
Quercetin : CK(318) : AC(136)
Diseases
:
Liver Cancer : CK(1641) : AC(266)
Pharmacological Actions
:
Apoptotic : CK(1489) : AC(1114)
,
Bcl-2 protein down-regulation : CK(49) : AC(38)
Resveratrol induces programmed cell death in human nasopharyngeal carcinoma cells.
Click here to read the entire abstract
Pubmed Data
: J Cell Physiol. 2011 Mar;226(3):720-8. PMID:
20717957
Article Published Date
: Mar 01, 2011
Study Type
: In Vitro Study
Additional Links
Substances
:
Resveratrol : CK(977) : AC(590)
Diseases
:
Nasopharyngeal Cancer : CK(58) : AC(21)
Pharmacological Actions
:
Apoptotic : CK(1489) : AC(1114)
,
Bcl-2 protein down-regulation : CK(49) : AC(38)
Additional Keywords
:
Stilbenes : CK(402) : AC(242)
Resveratrol inhibited the proliferation of pancreatic cancer cells by inducing programmed cell death.
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2010 Nov;24(11):1637-44. PMID:
21031621
Article Published Date
: Nov 01, 2010
Study Type
: In Vitro Study
Additional Links
Substances
:
Resveratrol : CK(977) : AC(590)
Diseases
:
Pancreatic Cancer : CK(530) : AC(168)
Pharmacological Actions
:
Antiproliferative : CK(1052) : AC(775)
,
Apoptotic : CK(1489) : AC(1114)
,
Bcl-2 protein down-regulation : CK(49) : AC(38)
,
Cell cycle arrest : CK(390) : AC(319)
Additional Keywords
:
Stilbenes : CK(402) : AC(242)
Silibinin-induces programmed cell death in breast cancer.
Click here to read the entire abstract
Pubmed Data
: Cancer Invest. 2011 Jan ;29(1):12-20. PMID:
21166494
Article Published Date
: Jan 01, 2011
Study Type
: In Vitro Study
Additional Links
Substances
:
Silibinin : CK(58) : AC(10)
Diseases
:
Breast Cancer : CK(2354) : AC(621)
Pharmacological Actions
:
Antiproliferative : CK(1052) : AC(775)
,
Apoptotic : CK(1489) : AC(1114)
,
Bcl-2 protein down-regulation : CK(49) : AC(38)
,
Caspase-8 activation : CK(2) : AC(1)
Sulforaphane has a chemopreventive effect in colon cancer cells.
Click here to read the entire abstract
Pubmed Data
: Chin J Physiol. 2012 Apr 30 ;55(2):134-44. PMID:
22559738
Article Published Date
: Apr 30, 2012
Study Type
: In Vitro Study
Additional Links
Substances
:
Sulforaphane : CK(520) : AC(171)
Diseases
:
Colon Cancer : CK(895) : AC(233)
Pharmacological Actions
:
Apoptotic : CK(1489) : AC(1114)
,
Bcl-2 protein down-regulation : CK(49) : AC(38)
,
Cell cycle arrest : CK(390) : AC(319)
,
Chemopreventive : CK(1528) : AC(382)
Tetrahydropalmatine protects against gamma-radiation induced damage to human endothelial cells.
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2010 Jul 3;87(1-2):55-63. Epub 2010 May 26. PMID:
20562023
Article Published Date
: Jul 03, 2010
Study Type
: In Vitro Study
Additional Links
Substances
:
Tetrahydropalmatine : CK(1) : AC(1)
Diseases
:
Oxidative Stress : CK(1945) : AC(710)
,
Radiation Induced Illness : CK(1018) : AC(249)
Pharmacological Actions
:
Apoptotic : CK(1489) : AC(1114)
,
Bcl-2 protein down-regulation : CK(49) : AC(38)
,
Radioprotective : CK(456) : AC(183)
Turmeric oil contains ar-turmerone which displays anti-lymphoma properties.
Click here to read the entire abstract
Pubmed Data
: BMB Rep. 2009 Feb 28;42(2):96-100. PMID:
19250610
Article Published Date
: Feb 28, 2009
Study Type
: In Vitro Study
Additional Links
Substances
:
Turmeric : CK(2995) : AC(1585)
,
Turmerones : CK(6) : AC(6)
Diseases
:
Lymphoma : CK(209) : AC(69)
Pharmacological Actions
:
Antioxidants : CK(3653) : AC(1318)
,
Apoptotic : CK(1489) : AC(1114)
,
Bcl-2 protein down-regulation : CK(49) : AC(38)
,
Caspase-3 Activation : CK(23) : AC(15)
,
Tumor Suppressor Protein p53 Upregulation : CK(146) : AC(105)
Additional Keywords
:
Plant Extracts : CK(3572) : AC(1216)
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