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Additional Topics Details for this Page
Article Count
- 21
Cumulative Knowledge
- 86
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View the Evidence: Pharmacological Actions
Beta Blockers, Calcium Channel Blockers, and Angiotensin-Converting Enzyme (ACE) Inhibitors increase the risk of ischemic stroke in comparison to a Diuretic alone.
Click here to read the entire abstract
Pubmed Data
: Arch Intern Med. 2001 Jan 8;161(1):37-43. PMID:
11146696
Article Published Date
: Jan 08, 2001
Study Type
: Human Study
Additional Links
Diseases
:
Hypertension : CK(2783) : AC(271)
Pharmacological Actions
:
Calcium Channel Blockers : CK(86) : AC(21)
Problem Substances
:
Angiotensin-Converting Enzyme (ACE) Inhibitor : CK(70) : AC(7)
,
Beta Blockers : CK(112) : AC(11)
In hypertensive patients the use of short-acting calcium channel blockers, especially in high doses, is associated with an increased risk of myocardial infarction.
Click here to read the entire abstract
Pubmed Data
: JAMA. 1995 Aug 23-30;274(8):620-5. PMID:
7637142
Article Published Date
: Aug 23, 1995
Study Type
: Human Study
Additional Links
Diseases
:
Hypertension : CK(2783) : AC(271)
,
Myocardial Infarction : CK(2632) : AC(117)
Pharmacological Actions
:
Calcium Channel Blockers : CK(86) : AC(21)
In patients with hypertension, diuretics plus calcium channel blockers were associated with a higher risk of myocardial infarction than other common two drug treatment regimens.
Click here to read the entire abstract
Pubmed Data
: BMJ. 2010;340:c103. Epub 2010 Jan 25. PMID:
20100777
Article Published Date
: Jan 01, 2010
Study Type
: Human Study
Additional Links
Diseases
:
Myocardial Infarction : CK(2632) : AC(117)
Pharmacological Actions
:
Calcium Channel Blockers : CK(86) : AC(21)
Problem Substances
:
Diuretic Drugs : CK(40) : AC(4)
Olive leaf extract has calcium channel blocking activity consistent with its traditional role in the treatment of cardiovascular disease.
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2008 Nov 20;120(2):233-40. Epub 2008 Aug 23. PMID:
18790040
Article Published Date
: Nov 20, 2008
Study Type
: Human Study
Additional Links
Substances
:
Olive leaf extract : CK(132) : AC(26)
Diseases
:
Hypertension : CK(2783) : AC(271)
Pharmacological Actions
:
Calcium Channel Blockers : CK(86) : AC(21)
Pycnogenol prevents damage in the microcirculation of hypertensive patients, and allows the dose of anti-hypertensive drugs to be reduced in most patients.
Click here to read the entire abstract
Pubmed Data
: Clin Appl Thromb Hemost. 2006 Oct;12(4):440-4. PMID:
17000888
Article Published Date
: Oct 01, 2006
Study Type
: Human Study
Additional Links
Substances
:
Flavonoids : CK(909) : AC(289)
,
Pycnogenol (Pine Bark) : CK(385) : AC(61)
Diseases
:
Edema : CK(107) : AC(13)
,
Hypertension : CK(2783) : AC(271)
Pharmacological Actions
:
Antihypertensive Agents : CK(196) : AC(38)
,
Calcium Channel Blockers : CK(86) : AC(21)
,
Platelet Aggregation Inhibitors : CK(173) : AC(37)
Additional Keywords
:
Drug-Plant-Vitamin Synergies : CK(1011) : AC(268)
,
Drug Sparing : CK(451) : AC(49)
Selenium, glutathione, copper/zinc and superoxide dismutase may have therapeutic value in ALS.
Click here to read the entire abstract
Pubmed Data
: Scand J Rheumatol. 1995;24(2):85-93. PMID:
9726810
Article Published Date
: Jan 01, 1995
Study Type
: Human Study
Additional Links
Substances
:
Antioxidant formulas : CK(487) : AC(73)
,
Copper : CK(82) : AC(16)
,
Glutathione : CK(61) : AC(16)
,
Selenium : CK(574) : AC(94)
,
Superoxide dismutase : CK(16) : AC(5)
,
Zinc : CK(870) : AC(127)
Diseases
:
Amyotrophic Lateral Sclerosis : CK(350) : AC(68)
Pharmacological Actions
:
Calcium Channel Blockers : CK(86) : AC(21)
Atorvastatin induced multiple organ failure has been reported.
Click here to read the entire abstract
Pubmed Data
: J La State Med Soc. 2010 May-Jun;162(3):159-60. PMID:
20666169
Article Published Date
: May 01, 2010
Study Type
: Human: Case Report
Additional Links
Diseases
:
Multi-Organ Failure : CK(9) : AC(3)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions
:
Calcium Channel Blockers : CK(86) : AC(21)
Additional Keywords
:
Drug Synergy : CK(327) : AC(147)
Problem Substances
:
Atorvastatin : CK(491) : AC(90)
,
Statin Drugs : CK(3969) : AC(465)
Apigenin and quercetin may have a therapeutic role in preventing and treating gastric spasm.
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2009 Jul 3;85(1-2):85-90. Epub 2009 May 8. PMID:
19427869
Article Published Date
: Jul 03, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Apigenin : CK(76) : AC(51)
,
Quercetin : CK(318) : AC(136)
Diseases
:
Gastric Spasm : CK(18) : AC(6)
Pharmacological Actions
:
Antispasmodic : CK(112) : AC(29)
,
Calcium Channel Blockers : CK(86) : AC(21)
Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesis.
Click here to read the entire abstract
Pubmed Data
: Neurobiol Dis. 2009 May ;34(2):300-7. PMID:
19385063
Article Published Date
: Apr 30, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Cannabinoids : CK(195) : AC(53)
Diseases
:
Aging : CK(1351) : AC(369)
,
Aging: Brain : CK(1747) : AC(68)
,
Brain Inflammation : CK(79) : AC(35)
Pharmacological Actions
:
Anti-Inflammatory Agents : CK(1230) : AC(433)
,
Calcium Channel Blockers : CK(86) : AC(21)
,
Neuritogenic : CK(98) : AC(48)
,
Neuroprotective Agents : CK(962) : AC(480)
Ginger lowers blood pressure through blockade of voltage-dependent calcium channels.
Click here to read the entire abstract
Pubmed Data
: J Cardiovasc Pharmacol. 2005 Jan;45(1):74-80. PMID:
15613983
Article Published Date
: Jan 01, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Ginger : CK(310) : AC(89)
Diseases
:
Hypertension : CK(2783) : AC(271)
Pharmacological Actions
:
Antihypertensive Agents : CK(196) : AC(38)
,
Calcium Channel Blockers : CK(86) : AC(21)
Additional Keywords
:
Plant Extracts : CK(3572) : AC(1216)
Gynura procumbens decreases blood pressure in rats by vasodilatation via inhibition of calcium channels.
Click here to read the entire abstract
Pubmed Data
: Clinics (Sao Paulo). 2011;66(1):143-50. PMID:
21437451
Article Published Date
: Jan 01, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Gynura Procumbens : CK(12) : AC(7)
Diseases
:
Hypertension : CK(2783) : AC(271)
Pharmacological Actions
:
Calcium Channel Blockers : CK(86) : AC(21)
,
Vasodilator Agents : CK(262) : AC(54)
Mugwort (Artemisa vulgaris) exhibits antispasmodic and bronchodilator activities through blockade of muscarinic receptors and calcium influx.
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol.2009 Sep 12. PMID:
19751814
Article Published Date
: Sep 12, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Mugwort : CK(14) : AC(3)
Diseases
:
Abdominal Cramps : CK(98) : AC(4)
,
Asthma : CK(918) : AC(134)
,
Diarrhea : CK(544) : AC(72)
Pharmacological Actions
:
Anticholinergic : CK(4) : AC(2)
,
Calcium Channel Blockers : CK(86) : AC(21)
,
Cholinergic Antagonists : CK(3) : AC(2)
,
Muscarinic Antagonists : CK(2) : AC(2)
Noni has antispamodic and vasodilator effects.
Click here to read the entire abstract
Pubmed Data
: BMC Complement Altern Med. 2010 Jan 13;10(1):2. Epub 2010 Jan 13. PMID:
20070879
Article Published Date
: Jan 13, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Noni : CK(83) : AC(42)
Diseases
:
Cardiovascular Diseases : CK(5138) : AC(641)
,
Hypertension : CK(2783) : AC(271)
Pharmacological Actions
:
Antispasmodic : CK(112) : AC(29)
,
Calcium Channel Blockers : CK(86) : AC(21)
,
Vasodilator Agents : CK(262) : AC(54)
Red sage (764-3) prevents right ventricular collagen deposition induced by hypoxia (low oxygen) and has a therapeutic effect on monocrotaline -induced pulmontary hypertension in rats.
Click here to read the entire abstract
Pubmed Data
: Zhongguo Zhong Xi Yi Jie He Za Zhi. 1998 Feb;18(2):97-100. PMID:
11367654
Article Published Date
: Feb 01, 1998
Study Type
: Animal Study
Additional Links
Substances
:
Red Sage : CK(134) : AC(37)
Diseases
:
Pulmonary Hypertension : CK(89) : AC(33)
,
Right Ventricular Hypertrophy : CK(22) : AC(11)
Pharmacological Actions
:
Calcium Channel Blockers : CK(86) : AC(21)
Additional Keywords
:
Plant Extracts : CK(3572) : AC(1216)
Saffron acts as a calcium channel blocker on guinea-pig isolated heart.
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2008 Mar;22(3):330-4. PMID:
18058985
Article Published Date
: Mar 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Saffron : CK(135) : AC(34)
Pharmacological Actions
:
Calcium Channel Blockers : CK(86) : AC(21)
,
Cardiovascular Agents : CK(50) : AC(10)
Acorus calamus has antispasmodic activitity mediated through calcium channel blockade, confirming its traditional use for gastrointestinal disorders such as colic pain and diarrhea.
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2006 Dec;20(12):1080-4. PMID:
17009206
Article Published Date
: Dec 01, 2006
Study Type
: In Vitro Study
Additional Links
Diseases
:
Colic : CK(74) : AC(12)
,
Diarrhea : CK(544) : AC(72)
Pharmacological Actions
:
Antidiarrheals : CK(48) : AC(9)
,
Calcium Channel Blockers : CK(86) : AC(21)
Additional Keywords
:
Plant Extracts : CK(3572) : AC(1216)
Calendula flowers have both spasmogenic and spasmolytic properties, providing a basis for its traditional use in abdominal cramps and constipation.
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2006 Oct;20(10):906-10. PMID:
16906636
Article Published Date
: Oct 01, 2006
Study Type
: In Vitro Study
Additional Links
Substances
:
Flowers : CK(27) : AC(14)
,
Marigold : CK(37) : AC(8)
Diseases
:
Abdominal Cramps : CK(98) : AC(4)
,
Constipation : CK(316) : AC(36)
Pharmacological Actions
:
Calcium Channel Blockers : CK(86) : AC(21)
,
Cholinergic Agents : CK(3) : AC(2)
Contrast-associated nephropathy is a major cause of iatrogenic acute renal failure.
Click here to read the entire abstract
Pubmed Data
: Heart Dis. 2002 Nov-Dec;4(6):372-9. PMID:
12441014
Article Published Date
: Nov 01, 2002
Study Type
: Review
Additional Links
Diseases
:
Iatrogenic Disease : CK(62) : AC(7)
,
Kidney Failure : CK(668) : AC(41)
,
Kidney Failure: Acute : CK(51) : AC(11)
Pharmacological Actions
:
Calcium Channel Blockers : CK(86) : AC(21)
,
Vasodilator Agents : CK(262) : AC(54)
Anti Therapeutic Actions
:
X-ray Diagnostic Technologies : CK(382) : AC(52)
Curcumin induces heat shock protein and inhibits p53 gene expression in colorectal cancer cells.
Click here to read the entire abstract
Pubmed Data
: Pediatrics. 2005 May;115(5):1360-6. PMID:
8989916
Article Published Date
: May 01, 2005
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin : CK(2910) : AC(1482)
Diseases
:
Colorectal Cancer : CK(877) : AC(321)
Pharmacological Actions
:
Apoptotic : CK(1489) : AC(1114)
,
Calcium Channel Blockers : CK(86) : AC(21)
,
Cell cycle arrest : CK(390) : AC(319)
,
Heat Shock Protein Inducer : CK(51) : AC(17)
,
Tumor Suppressor Protein p53 Upregulation : CK(146) : AC(105)
Curcumin inhibits ACTH- and angiotensin II-stimulated cortisol secretion.
Click here to read the entire abstract
Pubmed Data
: J Nat Prod. 2009 Aug;72(8):1533-7. PMID:
19653644
Article Published Date
: Aug 01, 2009
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin : CK(2910) : AC(1482)
Diseases
:
Cortisol: High : CK(841) : AC(60)
Pharmacological Actions
:
Calcium Channel Blockers : CK(86) : AC(21)
Magnesium may function in a statin drug-like manner by positively modulating blood lipid profiles.
Click here to read the entire abstract
Pubmed Data
: J Am Coll Nutr. 2004 Oct;23(5):501S-505S. PMID:
15466951
Article Published Date
: Oct 01, 2004
Study Type
: Review
Additional Links
Substances
:
Magnesium : CK(826) : AC(120)
Diseases
:
Hypercholesterolemia : CK(1517) : AC(165)
Pharmacological Actions
:
Calcium Channel Blockers : CK(86) : AC(21)
Additional Keywords
:
Natural Substances Versus Drugs : CK(988) : AC(165)
Saw palmetto extract has a broad range of therapeutic pharmacological actions relevant to benign prostatic hyperplasia.
Click here to read the entire abstract
Pubmed Data
: Biol Pharm Bull. 2009 Apr;32(4):646-50. PMID:
19336899
Article Published Date
: Apr 01, 2009
Study Type
: Review
Additional Links
Substances
:
Saw Palmetto : CK(82) : AC(17)
Diseases
:
Prostatic Hyperplasia: Benign : CK(202) : AC(46)
Pharmacological Actions
:
5-alpha reductase inhibitor : CK(42) : AC(13)
,
Adrenergic alpha-Agonists : CK(4) : AC(3)
,
Calcium Channel Blockers : CK(86) : AC(21)
Health Guide: Heart Health
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