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Article Count - 196
Cumulative Knowledge - 767

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Name	Cumulative Knowledge	Article Count	Focus Articles
Omega-3 Fatty Acids	74	6	Log in \| Sign up
Curcumin	62	34	Log in \| Sign up

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View the Evidence: Pharmacological Actions

Cardiac mortality is associated with low levels of omega-3 and omega-6 fatty acids in the heart of cadavers with a history of coronary heart disease.

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Pubmed Data : Nutr Res. 2009 Oct;29(10):696-704. PMID: 19917448

Article Published Date : Oct 01, 2009

Study Type : Meta Analysis

Additional Links

Substances : Omega-3 Fatty Acids : CK(3333) : AC(319), Omega-6 Fatty Acids : CK(30) : AC(2)

Diseases : Cardiac Mortality : CK(703) : AC(67), Coronary Artery Disease : CK(1305) : AC(136)

Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

Cardiovascular risks are significantly lower in individuals who excrete higher levels of magnesium and taurine, indicating their protective roles.

Click here to read the entire abstract

Pubmed Data : J Biomed Sci. 2010;17 Suppl 1:S21. Epub 2010 Aug 24. PMID: 20804596

Article Published Date : Jan 01, 2010

Study Type : Meta Analysis

Additional Links

Substances : Magnesium : CK(826) : AC(120), Taurine : CK(145) : AC(33)

Diseases : Cardiac Mortality : CK(703) : AC(67), Cardiovascular Diseases : CK(5138) : AC(641)

Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

Chocolate consumption is associated with a substantial reduction in the risk of cardiometabolic disorders.

Click here to read the entire abstract

Pubmed Data : BMJ. 2011 ;343:d4488. Epub 2011 Aug 26. PMID: 21875885

Article Published Date : Jan 01, 2011

Study Type : Meta Analysis

Additional Links

Substances : Chocolate : CK(243) : AC(32)

Diseases : Blood Sugar Problems : CK(4050) : AC(693), Cardiovascular Diseases : CK(5138) : AC(641), Coronary Artery Disease : CK(1305) : AC(136), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Metabolic Syndrome X : CK(645) : AC(122), Stroke : CK(540) : AC(47)

Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

CoQ(10) may improve the ejection fraction in patients with congestive heart failure.

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Pubmed Data : Am J Clin Nutr. 2012 Dec 5. Epub 2012 Dec 5. PMID: 23221577

Article Published Date : Dec 04, 2012

Study Type : Meta Analysis

Additional Links

Substances : Coenzyme Q10 : CK(667) : AC(104)

Diseases : Congestive Heart Failure : CK(256) : AC(30), Heart Failure : CK(711) : AC(97)

Pharmacological Actions : Cardioprotective : CK(702) : AC(196), Cardiotonic Agents : CK(46) : AC(7)

Dietary supplementation with omega-3 fatty acids reduces the incidence of sudden cardiac death in patients with myocardial infarction.

Click here to read the entire abstract

Pubmed Data : Ann Med. 2009;41(4):301-10. PMID: 19148838

Article Published Date : Jan 01, 2009

Study Type : Meta Analysis

Additional Links

Substances : Omega-3 Fatty Acids : CK(3333) : AC(319)

Diseases : Cardiac Arrest : CK(40) : AC(2), Cardiac Mortality : CK(703) : AC(67), Coronary Artery Disease : CK(1305) : AC(136), Myocardial Infarction : CK(2632) : AC(117)

Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

Fish and long-chain omega-3 fatty acid intake reduce the risk of coronary heart disease and total mortality in diabetic women.

Click here to read the entire abstract

Pubmed Data : Circulation. 2003 Apr 15;107(14):1852-7. Epub 2003 Mar 31. PMID: 12668520

Article Published Date : Apr 15, 2003

Study Type : Meta Analysis

Additional Links

Substances : Fish : CK(241) : AC(21), Omega-3 Fatty Acids : CK(3333) : AC(319)

Diseases : Coronary Artery Disease : CK(1305) : AC(136), Diabetes: Cardiovascular Illness : CK(666) : AC(104), Mortality: All-Cause : CK(644) : AC(55)

Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

Grape seed extract reduces blood pressure, a cardiovascular risk marker.

Click here to read the entire abstract

Pubmed Data : J Am Diet Assoc. 2011 Aug ;111(8):1173-81. PMID: 21802563

Article Published Date : Aug 01, 2011

Study Type : Meta Analysis

Additional Links

Substances : Grape Seed Extract : CK(168) : AC(57)

Diseases : Cardiovascular Diseases : CK(5138) : AC(641), Hypertension : CK(2783) : AC(271)

Pharmacological Actions : Cardioprotective : CK(702) : AC(196), Hypotensive : CK(383) : AC(53)

A nut-enriched diet has cholesterol-lowering properties, and olive oil has a cholesterol-lowering property independent of its fatty acid content.

Click here to read the entire abstract

Pubmed Data : Nutr Metab Cardiovasc Dis. 2011 Jun ;21 Suppl 1:S14-20. Epub 2011 Mar 21. PMID: 21421296

Article Published Date : May 31, 2011

Study Type : Human Study

Additional Links

Substances : Almond : CK(107) : AC(15), Olive : CK(401) : AC(97), Walnut : CK(163) : AC(26)

Diseases : Cardiovascular Diseases : CK(5138) : AC(641), High Cholesterol : CK(1718) : AC(198), Inflammation : CK(1077) : AC(363), Lipid Peroxidation : CK(403) : AC(127)

Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142), Cardioprotective : CK(702) : AC(196)

Aged garlic extract supplemented with B vitamins, folic acid and L-arginine retards the progression of subclinical atherosclerosis.

Click here to read the entire abstract

Pubmed Data : Breast Cancer Res Treat. 2004 Feb;83(3):221-31. PMID: 19573556

Article Published Date : Feb 01, 2004

Study Type : Human Study

Additional Links

Substances : Arginine : CK(970) : AC(169), B-complex : CK(278) : AC(32), Garlic : CK(485) : AC(160), Vitamin B-12 : CK(752) : AC(94)

Diseases : Arterial Calcification : CK(154) : AC(25), Atherosclerosis : CK(523) : AC(77), Hypertension : CK(2783) : AC(271)

Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Aged garlic extract with supplement is associated with increase in brown adipose, decrease in white adipose tissue and predict lack of progression in coronary atherosclerosis.

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Pubmed Data : Int J Cardiol. 2013 Mar 1. Epub 2013 Mar 1. PMID: 23453866

Article Published Date : Feb 28, 2013

Study Type : Human Study

Additional Links

Substances : Garlic : CK(485) : AC(160)

Diseases : Arterial Calcification : CK(154) : AC(25), Coronary Artery Disease : CK(1305) : AC(136), High Homocysteine : CK(368) : AC(57)

Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

C-Reactive Protein shows a predictive role in cardiovascular disease in patients with subclinical carotid artherosclerosis.

Click here to read the entire abstract

Pubmed Data : J Burn Care Rehabil. 2005 Nov-Dec;26(6):515-24. PMID: 18317426

Article Published Date : Nov 01, 2005

Study Type : Human Study

Additional Links

Diseases : C-Reactive Protein : CK(819) : AC(74), Cardiovascular Diseases : CK(5138) : AC(641), Carotid Stenosis : CK(209) : AC(14)

Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

Chocolate consumption is inversely associated with prevalent coronary heart disease.

Click here to read the entire abstract

Pubmed Data : Clin Nutr. 2010 Sep 19. Epub 2010 Sep 19. PMID: 20858571

Article Published Date : Sep 19, 2010

Study Type : Human Study

Additional Links

Substances : Cocoa : CK(243) : AC(32)

Diseases : Cardiovascular Diseases : CK(5138) : AC(641), Coronary Artery Disease : CK(1305) : AC(136)

Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

Additional Keywords : Risk Reduction : CK(1909) : AC(196)

Chocolate consumption was associated with lower cardiac mortality in a dose dependent manner in patients free of diabetes surviving their first heart attack.

Click here to read the entire abstract

Pubmed Data : J Intern Med. 2009 Sep;266(3):248-57. PMID: 19711504

Article Published Date : Sep 01, 2009

Study Type : Human Study

Additional Links

Diseases : Cardiac Mortality : CK(703) : AC(67), Cardiovascular Diseases : CK(5138) : AC(641), Heart Failure : CK(711) : AC(97), Myocardial Infarction : CK(2632) : AC(117)

Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

Additional Keywords : Risk Reduction : CK(1909) : AC(196)

Chronic daily consumption of a resveratrol-containing grape nutraceutical could exert cardiovascular benefits in stable-CAD patients.

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Pubmed Data : Cardiovasc Drugs Ther. 2012 Dec 8. Epub 2012 Dec 8. PMID: 23224687

Article Published Date : Dec 07, 2012

Study Type : Human Study

Additional Links

Substances : Resveratrol : CK(977) : AC(590)

Diseases : Adiponectin: Low Levels : CK(88) : AC(25), Coronary Artery Disease : CK(1305) : AC(136)

Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Cardioprotective : CK(702) : AC(196)

Cocoa intake is inversely associated with blood pressure and 15-year cardiovascular (47% reduction) and all-cause mortality (50% reduction).

Click here to read the entire abstract

Pubmed Data : Arch Intern Med. 2006 Feb 27 ;166(4):411-7. PMID: 16505260

Article Published Date : Feb 27, 2006

Study Type : Human Study

Additional Links

Diseases : Cardiac Mortality : CK(703) : AC(67), Cardiovascular Diseases : CK(5138) : AC(641), Hypertension : CK(2783) : AC(271), Mortality: All-Cause : CK(644) : AC(55)

Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

Consumption of 1 oz of English walnuts per day may decrease cardiovascular risk.

Click here to read the entire abstract

Pubmed Data : J Med Food. 2011 Sep ;14(9):890-8. Epub 2011 Apr 13. PMID: 21488754

Article Published Date : Sep 01, 2011

Study Type : Human Study

Additional Links

Substances : Walnut : CK(163) : AC(26)

Diseases : Cardiovascular Diseases : CK(5138) : AC(641), Endothelial Dysfunction : CK(897) : AC(173)

Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

Curcuminoids reduce the frequency of acute myocardial infarction after coronary artery bypass grafting.

Click here to read the entire abstract

Pubmed Data : Am J Cardiol. 2012 Jul 1 ;110(1):40-4. Epub 2012 Apr 3. PMID: 22481014

Article Published Date : Jun 30, 2012

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Coronary Bypass Surgery : CK(100) : AC(10), Myocardial Infarction : CK(2632) : AC(117)

Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

Additional Keywords : Phytotherapy : CK(177) : AC(27)

Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease, cardiac mortality, aortic calcification and all-cause mortality.

Click here to read the entire abstract

Pubmed Data : J Nutr. 2004 Nov;134(11):3100-5. PMID: 15514282

Article Published Date : Nov 01, 2004

Study Type : Human Study

Additional Links

Substances : Vitamin K : CK(550) : AC(65), Vitamin K2 : CK(277) : AC(32), Vitamin K2: Menaquinone-7 : CK(88) : AC(14)

Diseases : Aortic Calcification : CK(180) : AC(7), Arteriosclerosis : CK(2154) : AC(123), Cardiac Mortality : CK(703) : AC(67), Coronary Artery Disease : CK(1305) : AC(136), Mortality: All-Cause : CK(644) : AC(55), Myocardial Infarction : CK(2632) : AC(117)

Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

Garlic may provide an ideal alternative to acetylsalicylic acid (aspirin) in arteriosclerosis prevention.

Click here to read the entire abstract

Pubmed Data : Inflammopharmacology. 2008 Apr;16(2):87-95. PMID: 2071264

Article Published Date : Apr 01, 2008

Study Type : Human Study

Additional Links

Substances : Garlic : CK(485) : AC(160)

Diseases : Arteriosclerosis : CK(2154) : AC(123)

Pharmacological Actions : Anti-Platelet : CK(117) : AC(31), Cardioprotective : CK(702) : AC(196)

Additional Keywords : Natural Substances Versus Drugs : CK(988) : AC(165)

Glabridin, a compound found within licorice, inhibits LDL oxidation.

Click here to read the entire abstract

Pubmed Data : Toxicol Ind Health. 2009 May;25(4-5):321-4. PMID: 19651803

Article Published Date : May 01, 2009

Study Type : Human Study

Additional Links

Substances : Licorice : CK(257) : AC(81)

Diseases : Cholesterol: Oxidation : CK(457) : AC(98)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Cardioprotective : CK(702) : AC(196)

Green tea catechins improve human forearm endothelial dysfunction and have anti-atherosclerotic effects in smokers.

Click here to read the entire abstract

Pubmed Data : Circ J. 2010 Feb 4. Epub 2010 Feb 4. PMID: 20134098

Article Published Date : Feb 04, 2010

Study Type : Human Study

Additional Links

Substances : Catechin : CK(403) : AC(130), Green Tea : CK(930) : AC(294)

Diseases : Atherosclerosis : CK(523) : AC(77), C-Reactive Protein : CK(819) : AC(74), Endothelial Dysfunction : CK(897) : AC(173), Smoking: Cardiovascular Disease : CK(60) : AC(6)

Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

High antioxidant intake is associated with lower blood concentrations of C-reactive protein and plasma homocysteine concentrations in US adults.c

Click here to read the entire abstract

Pubmed Data : Public Health Nutr. 2011 Mar 18:1-10. Epub 2011 Mar 18. PMID: 21414247

Article Published Date : Mar 18, 2011

Study Type : Human Study

Additional Links

Substances : Antioxidant formulas : CK(487) : AC(73), Carotenoids : CK(1055) : AC(213), Vitamin C : CK(1274) : AC(238), Vitamin E : CK(1285) : AC(221)

Diseases : C-Reactive Protein : CK(819) : AC(74), High Homocysteine : CK(368) : AC(57)

Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

High dietary menaquinone (Vitamin K2) intake is associated with reduced coronary calcification.

Click here to read the entire abstract

Pubmed Data : Atherosclerosis. 2009 Apr;203(2):489-93. Epub 2008 Jul 19. PMID: 18722618

Article Published Date : Apr 01, 2009

Study Type : Human Study

Additional Links

Substances : Menaquinone : CK(20) : AC(2), Vitamin K2 : CK(277) : AC(32)

Diseases : Arterial Calcification : CK(154) : AC(25), Cardiovascular Diseases : CK(5138) : AC(641), Coronary Artery Disease : CK(1305) : AC(136)

Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

Just three servings weekly of blueberries or strawberries reduced the risk of heart attack in middle aged women by 33% compared to those eating berries once monthly or less in what seems to be an intake dependant manner.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Circulation. 2013 Jan 15 ;127(2):188-96. PMID: 23319811

Article Published Date : Jan 14, 2013

Study Type : Human Study

Additional Links

Substances : Anthocyanins : CK(56) : AC(19), Blueberry : CK(140) : AC(39), Strawberry : CK(51) : AC(13)

Diseases : Heart Disease, Myocardial Infarction: Prevention : CK(54) : AC(3)

Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

Additional Keywords : Diet

L-arginine improves endothelial function and vascular elastic properties of the arterial tree during the acute phase of smoking.

Click here to read the entire abstract

Pubmed Data : Am J Hypertens. 2009 Jun;22(6):586-92. Epub 2009 Mar 19. PMID: 19300425

Article Published Date : Jun 01, 2009

Study Type : Human Study

Additional Links

Substances : Arginine : CK(970) : AC(169)

Diseases : Endothelial Dysfunction : CK(897) : AC(173), Peripheral Vascular Diseases : CK(221) : AC(23), Smoking : CK(577) : AC(86), Tobacco Toxicity : CK(166) : AC(15)

Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

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