Cell cycle arrest

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View the Evidence: Pharmacological Actions

Lycopene inhibits liver cancer cell growth.

Pubmed Data : Biofactors. 2005 ;23(3):129-39. PMID: 16410635
Article Published Date : Jan 01, 2005
Study Type : Meta Analysis
Additional Links
Substances : Lycopene : CK(194) : AC(38)
Diseases : Liver Cancer : CK(1641) : AC(266)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Antiproliferative : CK(1052) : AC(775), Cell cycle arrest : CK(390) : AC(319)

Chinese motherwort has cytotoxicity against human breast cancer cells that is non-apoptic and estrogen receptor independent.

Pubmed Data : J Ethnopharmacol. 2009 Mar 18;122(2):234-9. PMID: 19330917
Article Published Date : Mar 18, 2009
Study Type : Human Study
Additional Links
Substances : Motherwort : CK(50) : AC(14)
Diseases : Breast Cancer : CK(2354) : AC(621)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Human bladder cancer cells and immortalized normal bladder cells were studied using Frankincense oil; Frankincense oil appears to distinguish cancerous from normal bladder cells and suppress cancer cell viability.

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2009 ;9:6. Epub 2009 Mar 18. PMID: 19296830
Article Published Date : Dec 31, 2008
Study Type : Human In Vitro
Additional Links
Substances : Frankincense : CK(22) : AC(1)
Diseases : Bladder Cancer : CK(186) : AC(60)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216), Selective Cytotoxicity : CK(58) : AC(41)

This study compares Boswellia sacra essential oil hydrodistilled at 100 °C vs 78 °C in inducing cancer cell death in cultured breast cancer cells; the oil prepared at 100 °C was more potent in inducing breast cancer cell-specific cytotoxicity.

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2011 ;11:129. Epub 2011 Dec 15. PMID: 22171782
Article Published Date : Dec 31, 2010
Study Type : Human In Vitro
Additional Links
Substances : Frankincense : CK(22) : AC(1)
Diseases : Breast Cancer : CK(2354) : AC(621), Cancer Metastasis : CK(272) : AC(135)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)
Additional Keywords : Selective Cytotoxicity : CK(58) : AC(41)

"Antineoplaston AS2-1 showed an antimetastatic effect against post-operative lung metastases from colon cancer through G1 cell arrest and the subsequent induction of apoptosis."

Pubmed Data : Oncol Rep. 2005 Mar ;13(3):389-95. PMID: 15706406
Article Published Date : Mar 01, 2005
Study Type : Animal Study
Additional Links
Substances : Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine) : CK(92) : AC(1)
Diseases : Cancer Metastasis : CK(272) : AC(135), Colon Cancer : CK(895) : AC(233), Lung Cancer: Metastatic : CK(4) : AC(1), Post-Operative Lung Metastasis of Colon Cancer : CK(2) : AC(1)
Pharmacological Actions : Anti-metastatic : CK(192) : AC(115), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)

Allomelanins suppress the tumor cell growth in vitro and in vivo.

Pubmed Data : Cancer Biother Radiopharm. 1997 Aug;12(4):273-6. PMID: 10851475
Article Published Date : Aug 01, 1997
Study Type : Animal Study
Additional Links
Substances : Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)
Diseases : Lymphoma : CK(209) : AC(69)
Pharmacological Actions : Cell cycle arrest : CK(390) : AC(319)
Additional Keywords : Food Colors: Black : CK(3) : AC(2), Food Colors: Purple : CK(3) : AC(2)

An ethanol extract of Shitake (Lentinula elodes) selectively kills skin cancer cells in mice.

Pubmed Data : Cancer Lett. 2005 Mar 18;220(1):21-8. PMID: 15737684
Article Published Date : Mar 18, 2005
Study Type : Animal Study
Additional Links
Substances : Shiitake Mushroom : CK(24) : AC(17)
Diseases : Skin Cancer : CK(417) : AC(171)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)
Additional Keywords : Antiproliferative : CK(5) : AC(3), Selective Cytotoxicity : CK(58) : AC(41)

Antrodia camphorata extract, when combined with anti-tumor agents, showed adjuvant antiproliferative effects on multi-drug resistant hepatoma.

Pubmed Data : J Ethnopharmacol. 2008 Aug 13;118(3):387-95. Epub 2008 May 7. PMID: 18571350
Article Published Date : Aug 13, 2008
Study Type : Animal Study
Additional Links
Substances : Antrodia camphorata : CK(7) : AC(4)
Diseases : Cancers: Multi-Drug Resistant : CK(92) : AC(73), Liver Cancer : CK(1641) : AC(266)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Cell cycle arrest : CK(390) : AC(319), Cyclooxygenase 2 Inhibitors : CK(269) : AC(169)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Combined curcumin and resveratrol reduces prostate cancer incidence in mice.

Pubmed Data : Int J Cancer. 2009 Jul 1;125(1):1-8. PMID: 19326431
Article Published Date : Jul 01, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482), Resveratrol : CK(977) : AC(590)
Diseases : Prostate Cancer : CK(998) : AC(288)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)
Additional Keywords : Natural Substance Synergy : CK(144) : AC(81), Stilbenes : CK(402) : AC(242)

Curcumin has anti-umorigenic and hormone-suppressive effects against pituitary tumors.

Pubmed Data : Endocr Relat Cancer. 2009 Dec;16(4):1339-50. Epub 2009 Sep 2. PMID: 19726538
Article Published Date : Dec 01, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Pituitary Tumours : CK(14) : AC(10)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)

Curcumin inhibits the proliferation of human oral cancer cells.

Pubmed Data : Am J Chin Med. 2010;38(2):343-58. PMID: 20387230
Article Published Date : Jan 01, 2010
Study Type : Transgenic Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Oral Cancer : CK(66) : AC(43), Squamous cell carcinoma : CK(79) : AC(36)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Cell cycle arrest : CK(390) : AC(319)

Curcumin inhibits tumorigenesis in mice.

Pubmed Data : Phytother Res. 2009 Nov;23(11):1524-30. PMID: 9591190
Article Published Date : Nov 01, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Tumors : CK(197) : AC(110)
Pharmacological Actions : Anti-Tumor : CK(69) : AC(44), Anticarcinogenic Agents : CK(521) : AC(275), Cell cycle arrest : CK(390) : AC(319)

Curcumin reduces pulmonary tumorigenesis in transgenic mice.

Pubmed Data : Mol Nutr Food Res. 2011 Jul ;55(7):1036-43. Epub 2011 May 2. PMID: 21538854
Article Published Date : Jul 01, 2011
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Lung Cancer : CK(496) : AC(198)
Pharmacological Actions : Cell cycle arrest : CK(390) : AC(319), Vascular Endothelial Growth Factor A Inhibitor : CK(102) : AC(58)

Curcumin suppresses the growth of malignant gliomas.

Pubmed Data : Neurosurg Focus. 2009 Feb;26(2):E8. PMID: 17395690
Article Published Date : Feb 01, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Glioma : CK(74) : AC(40)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319), NF-kappaB Inhibitor : CK(595) : AC(401)

Dietary stearate prevents breast cancer carcinogenesis.

Pubmed Data : Carcinogenesis. 2011 Aug ;32(8):1251-8. Epub 2011 May 17. PMID: 21586513
Article Published Date : Aug 01, 2011
Study Type : Animal Study
Additional Links
Substances : Saturated fatty acids : CK(175) : AC(5), Stearic Acid (stearate) : CK(23) : AC(8)
Diseases : Breast Cancer : CK(2354) : AC(621)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Cell cycle arrest : CK(390) : AC(319), Chemopreventive : CK(1528) : AC(382)

Gac fruit extract inhibits colon tumor growth.

Pubmed Data : Int J Oncol. 2005 Apr;26(4):881-9. PMID: 15753981
Article Published Date : Apr 01, 2005
Study Type : Animal Study
Additional Links
Substances : Gac : CK(4) : AC(2)
Diseases : Colon Cancer : CK(895) : AC(233)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Cell cycle arrest : CK(390) : AC(319)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Galangin, a compound found within Alpinia galanga, acts as a chemosensitizer in drug-resistant leukemia cells.

Pubmed Data : Cancer Lett. 2008 Jul 8;265(2):289-97. Epub 2008 Apr 18. PMID: 18374481
Article Published Date : Jul 08, 2008
Study Type : Animal Study
Additional Links
Substances : Alpinia galanga : CK(5) : AC(4), Flavonoids : CK(909) : AC(289)
Diseases : Cancers: Drug Resistant : CK(225) : AC(147), Leukemia: Acute myelogenous leukemia (AML) : CK(96) : AC(28), Leukemia: Chronic myelogenous leukemia (CML) : CK(28) : AC(18)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319), Chemosensitizer : CK(197) : AC(159)

Grape seed extract inhibits in vitro and in vivo growth of human colorectal carcinoma cells.

Pubmed Data : Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6194-202. PMID: 17062697
Article Published Date : Oct 15, 2006
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract : CK(168) : AC(57)
Diseases : Colorectal Cancer : CK(877) : AC(321)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319), Chemopreventive : CK(1528) : AC(382)
Additional Keywords : Antineoplastic Agents : CK(69) : AC(28), Antiproliferative : CK(5) : AC(3), Plant Extracts : CK(3572) : AC(1216)

Green tea polyphenols and its constituent EGCG inhibits proliferation of human breast cancer cells in vitro and in vivo.

Pubmed Data : Cancer Lett. 2007 Jan 8;245(1-2):232-41. Epub 2006 Mar 6. PMID: 16519995
Article Published Date : Jan 08, 2007
Study Type : Animal Study
Additional Links
Substances : Catechin : CK(403) : AC(130), Flavonoids : CK(909) : AC(289), Green Tea : CK(930) : AC(294), Polyphenols : CK(427) : AC(174)
Diseases : Breast Cancer : CK(2354) : AC(621)
Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)

Inositol hexaphosphate inhibits the cell cycle of human breast and colon cancer cells.

Pubmed Data : Anticancer Res. 2001 Jul-Aug;21(4A):2393-403. PMID: 11724298
Article Published Date : Jul 01, 2001
Study Type : Animal Study
Additional Links
Substances : Inositol Hexaphosphate : CK(31) : AC(15)
Diseases : Breast Cancer : CK(2354) : AC(621), Colon Cancer : CK(895) : AC(233)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Cell cycle arrest : CK(390) : AC(319)

Isoliquiritigenin (ISL), a flavonoid chalcone that is present in licorice, shallot, and bean sprouts, has antitumorigenic activities in prostate tumor cells.

Pubmed Data : J Med Food. 2009 Feb;12(1):8-14. PMID: 19298190
Article Published Date : Feb 01, 2009
Study Type : Animal Study
Additional Links
Substances : Beans: All : CK(86) : AC(17), Flavonoids : CK(909) : AC(289), Isoliquiritigenin : CK(7) : AC(6), Licorice : CK(257) : AC(81), Shallot : CK(25) : AC(5), Sprouts : CK(76) : AC(36)
Diseases : Prostate Cancer : CK(998) : AC(288)
Pharmacological Actions : Cell cycle arrest : CK(390) : AC(319), Enzyme Inhibitors : CK(372) : AC(208)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Mixed tocotrienols inhibit prostate carcinogenesis in mice.

Pubmed Data : Nutr Cancer. 2010 Aug;62(6):789-94. PMID: 20661828
Article Published Date : Aug 01, 2010
Study Type : Animal Study
Additional Links
Substances : Tocotrienols : CK(22) : AC(16)
Diseases : Prostate Cancer : CK(998) : AC(288)
Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)

Propolis contains a compound which inhibits triple negative breast cancer in the animal model.

Pubmed Data : Cancer Lett. 2011 Sep 1;308(1):43-53. Epub 2011 May 13. PMID: 21570765
Article Published Date : Sep 01, 2011
Study Type : Animal Study
Additional Links
Substances : Bee Propolis : CK(220) : AC(83), Caffeic acid phenethyl ester : CK(15) : AC(8)
Diseases : Breast Cancer : CK(2354) : AC(621), Breast Cancer: Triple Negative : CK(61) : AC(13)
Pharmacological Actions : Anti-Angiogenic : CK(143) : AC(101), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319), NF-kappaB Inhibitor : CK(595) : AC(401)

Resveratrol may have therapeutic value in bone marrow diseases such as Fanconi anemia.

Pubmed Data : Blood. 2010 Dec 9;116(24):5140-8. Epub 2010 Sep 8. PMID: 20826722
Article Published Date : Dec 09, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol : CK(977) : AC(590)
Diseases : Bone Marrow Diseases : CK(2) : AC(1), Fanconi Anemia : CK(2) : AC(1), Hematopoietic Diseases : CK(2) : AC(1)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Cell cycle arrest : CK(390) : AC(319)
Additional Keywords : Stilbenes : CK(402) : AC(242)

Silibinin inhibits human hepatocellular carcinoma xenografts in nude mice.

Pubmed Data : World J Gastroenterol. 2009 Apr 28 ;15(16):1943-50. PMID: 19399925
Article Published Date : Apr 28, 2009
Study Type : Transgenic Animal Study
Additional Links
Substances : Milk Thistle : CK(226) : AC(55), Silibinin : CK(58) : AC(10)
Diseases : Liver Cancer : CK(1641) : AC(266)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319), Superoxide Dismutase Up-regulation : CK(131) : AC(42)

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