Cell cycle arrest

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View the Evidence: Pharmacological Actions

Homeopathic remedies have cytotoxic effects against breast cancer cell lines.

Pubmed Data : Int J Oncol. 2010 Feb;36(2):395-403. PMID: 20043074
Article Published Date : Feb 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Homeopathic Medicine: All : CK(481) : AC(47)
Diseases : Breast Cancer : CK(2354) : AC(621)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)

Honokiol inhibits vascular smooth muscle cell proliferation, indicating it may have a role in arteriosclerosis treatment.

Pubmed Data : Biochem Pharmacol. 2010 Apr 1;79(7):955-66. Epub 2009 Nov 13. PMID: 16962592
Article Published Date : Apr 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Honokiol : CK(6) : AC(4), Magnolia : CK(40) : AC(11)
Diseases : Arteriosclerosis : CK(2154) : AC(123)
Pharmacological Actions : Cell cycle arrest : CK(390) : AC(319), Enzyme Inhibitors : CK(372) : AC(208), Vascular smooth muscle cell (VSMC) inhibitor : CK(7) : AC(5)

Hydrogen peroxide inhibits lung cancer cells, in vitro.

Pubmed Data : Carcinogenesis. 1998 Aug;19(8):1357-60. PMID: 12054510
Article Published Date : Aug 01, 1998
Study Type : In Vitro Study
Additional Links
Substances : Hydrogen Peroxide : CK(7) : AC(7)
Diseases : Lung Cancer : CK(496) : AC(198)
Pharmacological Actions : Cell cycle arrest : CK(390) : AC(319)

Hypoxia may contribute to chemotherapy resistance in neuroblastoma cells.

Pubmed Data : Pharmazie. 2010 Jan;65(1):51-6. PMID: 20187579
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Diseases : Hypoxia : CK(100) : AC(41), Neuroblastoma : CK(52) : AC(31)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)
Additional Keywords : Diseases that are Linked : CK(2122) : AC(270)

Inositol hexaphosphate inhibits growth, and induces cell cycle arrest and programmed cell death of prostate carcinoma

Pubmed Data : Carcinogenesis. 2003 Mar;24(3):555-63. PMID: 12663518
Article Published Date : Mar 01, 2003
Study Type : In Vitro Study
Additional Links
Substances : Inositol Hexaphosphate : CK(31) : AC(15)
Diseases : Prostate Cancer : CK(998) : AC(288)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319), Enzyme Inhibitors : CK(372) : AC(208)

Inositol hexaphosphate inhibits growth, induces cell cycle arrest and programmed cell death of androgen-dependent human prostate carcinoma cells.

Pubmed Data : Neoplasia. 2004 Sep-Oct;6(5):646-59. PMID: 15548374
Article Published Date : Sep 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Inositol Hexaphosphate : CK(31) : AC(15)
Diseases : Prostate Cancer : CK(998) : AC(288)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)

Isoliquiritigenin is a natural flavonoid isolated from licorice, shallot and bean sprouts inhibits human lung cancer cell growth.

Pubmed Data : Cancer Lett. 2004 Apr 15;207(1):27-35. PMID: 15050731
Article Published Date : Apr 15, 2004
Study Type : In Vitro Study
Additional Links
Substances : Beans: All : CK(86) : AC(17), Flavonoids : CK(909) : AC(289), Isoliquiritigenin : CK(7) : AC(6), Licorice : CK(257) : AC(81), Shallot : CK(25) : AC(5), Sprouts : CK(76) : AC(36)
Diseases : Lung Cancer : CK(496) : AC(198)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Cell cycle arrest : CK(390) : AC(319), Enzyme Inhibitors : CK(372) : AC(208)

Isoliquiritigenin, a natural flavonoid found in licorice, shallots, and bean sprouts inhibits DNA damage, causes cell clycle arrest and inhibits proliferation in human cervical cancer cells.

Pubmed Data : Cancer Lett. 2009 May 18;277(2):174-81. Epub 2009 Jan 23. PMID: 19167809
Article Published Date : May 18, 2009
Study Type : In Vitro Study
Additional Links
Substances : Beans: All : CK(86) : AC(17), Isoliquiritigenin : CK(7) : AC(6), Licorice : CK(257) : AC(81), Shallot : CK(25) : AC(5), Sprouts : CK(76) : AC(36)
Diseases : Cervical Cancer : CK(363) : AC(69), DNA damage : CK(711) : AC(293)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Cell cycle arrest : CK(390) : AC(319)

Kava contains a compound inhibits the growth of bladder cancer cells.

Pubmed Data : Cancer Prev Res (Phila). 2008 Nov;1(6):439-51. PMID: 19138991
Article Published Date : Nov 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Kava Kava : CK(239) : AC(39)
Diseases : Bladder Cancer : CK(186) : AC(60), Cancers: Drug Resistant : CK(225) : AC(147)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Cell cycle arrest : CK(390) : AC(319)

Lactococcus lactis has an antiproliferative effect on human stomach cancer cells - Article 1.

Pubmed Data : Ann N Y Acad Sci. 2009 Aug;1171:270-5. PMID: 19723065
Article Published Date : Aug 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Lactococcus lactis : CK(13) : AC(4)
Diseases : Stomach Cancer : CK(373) : AC(20)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)

Lactococcus lactis has an antiproliferative effect on human stomach cancer cells - Article 2

Pubmed Data : Br J Nutr. 2009 Nov;102(10):1469-76. Epub 2009 Jul 23. PMID: 19624867
Article Published Date : Nov 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Lactococcus lactis : CK(13) : AC(4)
Diseases : Stomach Cancer : CK(373) : AC(20)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)

Laser-ultraviolet-A-induced ultraweak photon emission in mammalian cells.

Pubmed Data : J Biomed Opt. 2005 Mar-Apr;10(2):024006. PMID: 15910080
Article Published Date : Mar 01, 2005
Study Type : In Vitro Study
Additional Links
Diseases : Melanoma : CK(171) : AC(87)
Pharmacological Actions : Cell cycle arrest : CK(390) : AC(319)
Additional Keywords : Biophotons : CK(76) : AC(18)

Lignans are involved in the antitumor activity of wheat bran in colon cancer cells.

Pubmed Data : J Nutr. 2005 Mar;135(3):598-602. PMID: 15735100
Article Published Date : Mar 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Fiber : CK(484) : AC(70), Lignans : CK(110) : AC(31), Wheat Bran : CK(39) : AC(9)
Diseases : Colon Cancer : CK(895) : AC(233)
Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Cell cycle arrest : CK(390) : AC(319), Chemopreventive : CK(1528) : AC(382)

Lupeol inhibits human hepatocellular carcinoma cells.

Pubmed Data : Biol Pharm Bull. 2011 ;34(4):517-22. PMID: 21467639
Article Published Date : Jan 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Lupeol : CK(3) : AC(2)
Diseases : Liver Cancer : CK(1641) : AC(266)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Luteolin has anti-proliferative and chemosensitizing effects on human gastric cancer cells.

Pubmed Data : Mol Cell Biochem. 2008 Jun;313(1-2):125-32. Epub 2008 Apr 9. PMID: 18398671
Article Published Date : Jun 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Luteolin : CK(62) : AC(51)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66), Gastric Cancer : CK(373) : AC(111)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319), Chemosensitizer : CK(197) : AC(159)
Additional Keywords : Drug: Cisplatin : CK(31) : AC(11), Drug-Plant-Vitamin Synergies : CK(1011) : AC(268)

Luteolin induces cell cycle arrest and programmed cell death in human colon cancer cells.

Pubmed Data : Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G66-75. Epub 2006 Aug 10. PMID: 16901994
Article Published Date : Jan 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Luteolin : CK(62) : AC(51)
Diseases : Colon Cancer : CK(895) : AC(233)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)

Luteolini downregulates androgen receptor expression, inhibits cell proliferation and induces programmed cell death in human prostate cancer cells and xenografts.

Pubmed Data : Anticancer Res. 2005 Jan-Feb;25(1A):139-47. PMID: 18008333
Article Published Date : Jan 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Luteolin : CK(62) : AC(51)
Diseases : Prostate Cancer : CK(998) : AC(288)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)

Lycopen can induce programmed cell death and cell cycle arrest in hormone refractory prostate cancer cells.

Pubmed Data : Wei Sheng Yan Jiu. 2007 Sep;36(5):575-8. PMID: 18095570
Article Published Date : Sep 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Lycopene : CK(194) : AC(38)
Diseases : Prostate Cancer : CK(998) : AC(288)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)

Lycopene induces cell growth inhibition in a variety of cancer cell lines.

Pubmed Data : Carcinogenesis. 2010 Oct;31(10):1813-21. Epub 2010 Aug 10. PMID: 20699249
Article Published Date : Oct 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Carotenoids : CK(1055) : AC(213), Lycopene : CK(194) : AC(38)
Diseases : Colon Cancer : CK(895) : AC(233), Lung Cancer : CK(496) : AC(198), Prostate Cancer : CK(998) : AC(288)
Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319), NF-kappaB Inhibitor : CK(595) : AC(401)

Lycopene inhibits the growth of estrogen receptor positive breast cancer cells.

Pubmed Data : Sichuan Da Xue Xue Bao Yi Xue Ban. 2007 Nov;38(6):958-60, 976. PMID: 18095595
Article Published Date : Nov 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Lycopene : CK(194) : AC(38)
Diseases : Breast Cancer : CK(2354) : AC(621)
Pharmacological Actions : Cell cycle arrest : CK(390) : AC(319)

Maitake D-Fraction exhibits synergistic anti-cancer activity with interferon in prostate cancer cells.

Pubmed Data : J Hematol Oncol. 2008;1:25. Epub 2008 Dec 4. PMID: 19055833
Article Published Date : Jan 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom : CK(61) : AC(34)
Diseases : Prostate Cancer : CK(998) : AC(288)
Pharmacological Actions : Cell cycle arrest : CK(390) : AC(319)
Additional Keywords : Drug-Plant-Vitamin Synergies : CK(1011) : AC(268)

Maitake mushroom d-fraction exhibits a synergistic effect with interferon on inhibiting bladder cancer cells.

Pubmed Data : BJU Int. 2009 Sep 4. Epub 2009 Sep 4. PMID: 19735256
Article Published Date : Sep 04, 2009
Study Type : In Vitro Study
Additional Links
Substances : Maitake Mushroom : CK(61) : AC(34)
Diseases : Bladder Cancer : CK(186) : AC(60)
Pharmacological Actions : Cell cycle arrest : CK(390) : AC(319)
Additional Keywords : Drug-Plant-Vitamin Synergies : CK(1011) : AC(268)

Mangiferin can inhibit the proliferation of HL-60 leukemia cells.

Pubmed Data : Zhong Yao Cai. 2010 Jan;33(1):81-5. PMID: 20518311
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Mangiferin : CK(42) : AC(27)
Diseases : Leukemia : CK(670) : AC(258), Promyelocytic leukemia : CK(136) : AC(74)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Cell cycle arrest : CK(390) : AC(319)
Additional Keywords : Xanthones : CK(50) : AC(28)

Melatonin and vitamin D3 synergistically inhibit the growth of breast cancer cells.

Pubmed Data : J Pineal Res. 2011 Mar;50(2):150-8. Epub 2010 Nov 22. PMID: 21091766
Article Published Date : Mar 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Melatonin : CK(470) : AC(131), Vitamin D : CK(1682) : AC(238)
Diseases : Breast Cancer : CK(2354) : AC(621)
Pharmacological Actions : Cell cycle arrest : CK(390) : AC(319), Tumor Suppressor Protein p53 Upregulation : CK(146) : AC(105)
Additional Keywords : Natural Substance Synergy : CK(144) : AC(81)

Melatonin counteracts the pro-carcinogenic properties of estradiol in breast cancer cells.

Pubmed Data : J Pineal Res. 2009 Aug;47(1):23-31. Epub 2009 Jun 10. PMID: 19522736
Article Published Date : Aug 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Melatonin : CK(470) : AC(131)
Diseases : Breast Cancer : CK(2354) : AC(621), Estrogen Dominance : CK(106) : AC(37)
Pharmacological Actions : BRCA-1 Downregulation : CK(2) : AC(2), Cell cycle arrest : CK(390) : AC(319), Tumor Suppressor Protein p53 Upregulation : CK(146) : AC(105)

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