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Cyclooxygenase 2 Inhibitors
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Focused Research Topics
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176 Substances Researched for Cyclooxygenase 2 Inhibitors
Name
AC
CK
Focus
Curcumin
61
87
Flavonoids
13
27
Resveratrol
17
23
Omega-3 Fatty Acids
6
17
Sulforaphane
11
14
Apples
2
12
DHA (Docosahexaenoic Acid)
3
12
Spirulina
2
12
EPA (Eicosapentaenoic Acid)
2
11
Turmeric
2
11
Eicosapentaenoic acid (EPA)
1
10
Frankincense
1
10
Polyphenols
6
10
Strawberry
1
10
Vitamin C
1
10
Stilbenes
5
8
Cannabis
3
7
Melatonin
4
6
Astaxanthin
3
5
Berberine
3
5
Chrysin
3
5
Ginger
3
5
Noni
3
5
Pterostilbene
4
5
Wogonin
3
5
Anthocyanins
2
4
Black Tea
3
4
Bromelain
4
4
Dandelion
4
4
Flaxseed
2
4
Fucoidan
3
4
Ginkgo biloba
2
4
Lignans
2
4
Medium Chain Triglycerides
2
4
Nobiletin
3
4
Palm Oil
2
4
Pomegranate
3
4
Quercetin
3
4
Saturated fatty acids
2
4
Sweet Potato: Purple
2
4
Thymoquinone
2
4
18β-Glycyrrhetinic Acid
2
3
Antrodia camphorata
2
3
Apigenin
2
3
Blueberry
2
3
Chaga Mushroom (Inonotus obliquus)
2
3
Chinese Skullcap
2
3
Citrus Peel
2
3
Fermented Foods and Beverages
2
3
Ginseng (American)
2
3
Ginseng (Korean)
3
3
Mangiferin
2
3
Rose
2
3
Saffron
2
3
ALA (Alpha-Linolenic Acid)
1
2
Alpha Linolenic Acid
1
2
Apple Polyphenols
1
2
Arginine
1
2
Artemisia asiatica
1
2
Bee Propolis
1
2
Benzyl isothiocyanate
1
2
Boswellia
1
2
Brown Rice
1
2
Burdock
1
2
Caffeic acid phenethyl ester
1
2
Carrot
1
2
Catechin
2
2
Cocoa
1
2
Crocetin
1
2
Cyanidin 3-glucoside
1
2
Damnacanthal
1
2
EGCG (Epigallocatechin gallate)
2
2
Evening Primrose Oil
1
2
Fisetin
2
2
Fucoxanthin
1
2
Garcinia indica
1
2
Gardenia
1
2
Garlic
1
2
Gingerol
1
2
Grape Seed Extract
1
2
Graviola
1
2
Guggul
2
2
Hops
1
2
Kaempferia parviflora
1
2
L-Carnitine
1
2
Lactobacillus rhamnosus
1
2
Lion's Mane (Hericium Erinaceus)
1
2
Moringa oleifera
1
2
Mulberry
1
2
Myricetin
1
2
Noni leaf extract
1
2
Patchouli
1
2
Peony
1
2
Perilla
1
2
Pine Needle
1
2
Polyunsaturated Fatty Acids (PUFAs)
1
2
Potato
1
2
Probiotics
1
2
Raspberry
1
2
Red Wine
1
2
Rice Bran
1
2
Rosmarinic acid
1
2
Royal Jelly
1
2
Rutin
1
2
Sour Cherry
1
2
Tangeretin
1
2
Tongkat Ali
1
2
Walnut
1
2
Achillea fragrantissima
1
1
Alpha-Lipoic Acid
1
1
Artesunate
1
1
Asparagus
1
1
Avenanthramides
1
1
Avocado
1
1
Bamboo
1
1
Bee Venom
1
1
Beta-glucan
1
1
Betulinic acid
1
1
Black Pepper
1
1
Butterbur
1
1
Capsaicin
1
1
Chamomile
1
1
Cucurbitacin B
1
1
Cumin
1
1
Cyanidin
1
1
Echinacea
1
1
Ferulic acid
1
1
Feverfew
1
1
Fish Oil
1
1
Fruit: All
1
1
Ginsenosides
1
1
Gleditsia sinensis
1
1
Guava
1
1
Horseradish
1
1
Huperzine
1
1
Hyaluronic Acid
1
1
Hydroxytyrosol
1
1
Kava Kava
1
1
Kimchi
1
1
Long Pepper
1
1
Loquat Leaves
1
1
Lutein
1
1
Luteolin
1
1
Maitake Mushroom
1
1
Medicinal Mushrooms
1
1
Mushrooms: All
1
1
Mussel: Green-lipped (Perna canaliculus)
1
1
Oats
1
1
Oleuropein
1
1
Olive
1
1
Orange: Mandarin
1
1
Oranges
1
1
Phenethyl isothiocyanate
1
1
Piceatannol
1
1
Piperlongumine
1
1
Plantago
1
1
Prunella vulgaris.
1
1
Purple Carrots
1
1
Reishi Mushroom
1
1
Rice: Black
1
1
Rose Hips
1
1
Saw Palmetto
1
1
Sesame Seeds
1
1
Soy
1
1
Tabebuia
1
1
Theaflavins
1
1
Tocotrienol: Gamma
1
1
Toona sinensis
1
1
Truffles
1
1
Turmerones
1
1
Tyrosol
1
1
Unsaponifiables
1
1
Ursolic Acid
1
1
Vegetables: All
1
1
Wormwood
1
1
Wasabi
1
0
Research Articles
272
Cumulative Knowledge Score
440
Overall Research Rating
GREAT
View the Evidence:
479 Abstracts with Cyclooxygenase 2 Inhibitors Research
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[+]
A daily dose of 3.6 g curcumin achieves pharmacologically efficacious levels in the colorectum with negligible distribution of curcumin outside the gut.
Jan 01, 2005
Click here to read the entire abstract
Pubmed Data
: Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):120-5. PMID:
15668484
Article Published Date
: Jan 01, 2005
Study Type
: Human Study
Additional Links
Substances
:
Curcumin
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Antineoplastic Agents
[+]
A formulation containing Frankincense and Turmeric extracts demonstrated a greater improvement in the treatment of OA than celecoxib.
Oct 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Med Rep. 2013 Nov ;8(5):1542-8. Epub 2013 Aug 29. PMID:
24002213
Article Published Date
: Oct 31, 2013
Study Type
: Human Study
Additional Links
Substances
:
Frankincense
,
Turmeric
Diseases
:
Osteoarthritis: Knee
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Plant Extracts
,
Superiority of Natural Substances versus Drugs
Problem Substances
:
Celecoxib
,
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]
Carbohydrate ingestion from bananas had positive influence in attenuating metabolic perturbation and inflammation following 75-km cycling.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2018 ;13(3):e0194843. Epub 2018 Mar 22. PMID:
29566095
Article Published Date
: Dec 31, 2017
Study Type
: Human Study
Additional Links
Substances
:
Banana
Therapeutic Actions
:
Exercise: Cycling
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
[+]
Consumption of dried apple peel powder was associated with improved joint function and improved serum antioxidant protection status.
Oct 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Med Food. 2014 Nov ;17(11):1204-13. Epub 2014 Oct 1. PMID:
25271471
Article Published Date
: Oct 31, 2014
Study Type
: Human Study
Additional Links
Substances
:
Apples
Diseases
:
Joint Diseases
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antinoceceptive
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Lipoxygenase Inhibitors
Additional Keywords
:
Plant Extracts
,
Significant Treatment Outcome
[+]
Dietary strawberries significantly decreased the histologic grade of patients' precancerous esophageal lesions.
Dec 31, 2011
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancer Prev Res (Phila). 2012 Jan ;5(1):41-50. Epub 2011 Dec 1. PMID:
22135048
Article Published Date
: Dec 31, 2011
Study Type
: Human Study
Additional Links
Substances
:
Strawberry
Diseases
:
Esophageal Cancer
Pharmacological Actions
:
Antiproliferative
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Nitric Oxide Inhibitor
Additional Keywords
:
Plant Extracts
,
Risk Reduction
[+]
Electroacupuncture may prevent ischemia-reperfusion-induced endothelial dysfunction via a COX-2 dependent mechanism.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2017 ;12(6):e0178838. Epub 2017 Jun 7. PMID:
28591155
Article Published Date
: Dec 31, 2016
Study Type
: Human Study
Additional Links
Diseases
:
Endothelial Dysfunction
,
Ischemia
Therapeutic Actions
:
Electroacupuncture
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
[+]
Electroacupuncture treatment alleviates central post-stroke pain.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Neural Plast. 2016 ;2016:1437148. Epub 2016 Aug 27. PMID:
27774321
Article Published Date
: Dec 31, 2015
Study Type
: Human Study
Additional Links
Diseases
:
Stroke: Attenuation/Recovery
Therapeutic Actions
:
Electroacupuncture
Pharmacological Actions
:
Analgesics
,
Cyclooxygenase 2 Inhibitors
[+]
EPA supplementation significantly reduces Cox-2 enzyme expression in Barrett's esophagus.
Apr 01, 2008
Click here to read the entire abstract
Pubmed Data
: Am J Clin Nutr. 2008 Apr;87(4):949-56. PMID:
18400718
Article Published Date
: Apr 01, 2008
Study Type
: Human Study
Additional Links
Substances
:
EPA (Eicosapentaenoic Acid)
Diseases
:
Barrett Esophagus
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
[+]
Omega-3 fatty acids cause a reduction in the mRNA levels for various proteins known to be important in the pathology of osteoarthritis.
Jul 01, 2009
Click here to read the entire abstract
Pubmed Data
: Osteoarthritis Cartilage. 2009 Jul;17(7):896-905. Epub 2009 Jan 13. PMID:
19217322
Article Published Date
: Jul 01, 2009
Study Type
: Human Study
Additional Links
Substances
:
DHA (Docosahexaenoic Acid)
,
Eicosapentaenoic acid (EPA)
,
Omega-3 Fatty Acids
Diseases
:
Osteoarthritis
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 alpha downregulation
,
Interleukin-1 beta downregulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Phloretin inhibits the growth of P. acnes, P. granulosum, and S. epidermidis.
Jan 31, 2016
Click here to read the entire abstract
Pubmed Data
: Int J Cosmet Sci. 2016 Feb ;38(1):85-92. Epub 2015 Aug 30. PMID:
26212527
Article Published Date
: Jan 31, 2016
Study Type
: Human In Vitro, Human Study
Additional Links
Substances
:
Phloretin
Diseases
:
Acne
Pharmacological Actions
:
Anti-Bacterial Agents
,
Antimicrobial
,
Cyclooxygenase 2 Inhibitors
,
Prostaglandin PGE2 downregulation
[+]
Pycnogenol may be of value in treatment of MSU crystal-induced arthritis through its anti-inflammatory and anti-nitrosative activities.
Feb 14, 2012
Click here to read the entire abstract
Pubmed Data
: Free Radic Biol Med. 2012 Feb 15 ;52(4):765-74. Epub 2011 Dec 13. PMID:
22198264
Article Published Date
: Feb 14, 2012
Study Type
: Human Study
Additional Links
Substances
:
Flavonoids
Diseases
:
Gout
,
Hyperuricemia
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
[+]
Spirulina has favorable effects on lipid profiles, immune variables and antioxidant capacity in healthy individuals.
Jan 01, 2008
Click here to read the entire abstract
Pubmed Data
: Ann Nutr Metab. 2008;52(4):322-8. Epub 2008 Aug 19. PMID:
18714150
Article Published Date
: Jan 01, 2008
Study Type
: Human Study
Additional Links
Substances
:
Spirulina
Diseases
:
High Cholesterol
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Interleukin-2 upregulation
,
Interleukin-6 Downregulation
[+]
The anti-inflammatory activity of Cannabis extracts on colon epithelial cells derives from a fraction of the extract that contains THCA.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cannabis Cannabinoid Res. 2017 ;2(1):167-182. Epub 2017 Jul 1. PMID:
29082314
Article Published Date
: Dec 31, 2016
Study Type
: Human Study
Additional Links
Substances
:
Cannabinoids
,
Cannabis
Diseases
:
Inflammatory Bowel Diseases
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
These new data support a potential role of oleuropein in the treatment of ulcerative colitis.
Apr 14, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2017 Apr 15 ;9(4). Epub 2017 Apr 15. PMID:
28420140
Article Published Date
: Apr 14, 2017
Study Type
: Human Study
Additional Links
Substances
:
Oleuropein
Diseases
:
Ulcerative Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-17 downregulation
[+]
Vitamin C attenuates aspirin-induced gastric damage.
May 01, 2009
Click here to read the entire abstract
Pubmed Data
: Zhongguo Zhen Jiu. 2009 May;29(5):382-4. PMID:
17218764
Article Published Date
: May 01, 2009
Study Type
: Human Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Aspirin-Induced Toxicity
,
NSAID-induced toxicity
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
[+]
Cannabidiolic acid an active component in the cannabis plant offers potential therapeutic modality in the abrogation of cancer cell migration.
Nov 14, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Toxicol Lett. 2012 Nov 15 ;214(3):314-9. Epub 2012 Sep 8. PMID:
22963825
Article Published Date
: Nov 14, 2012
Study Type
: Human In Vitro
Additional Links
Substances
:
Cannabis
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
Pharmacological Actions
:
Anti-metastatic
,
Antineoplastic Agents
,
Antiproliferative
,
Cyclooxygenase 2 Inhibitors
,
Enzyme Inhibitors
[+]
Ginsenoside Rg1 can inhibit inflammatory responses in human chondrocytes in vitro and reduce articular cartilage damage in vivo.
Mar 09, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2017 Mar 10 ;9(3). Epub 2017 Mar 10. PMID:
28287423
Article Published Date
: Mar 09, 2017
Study Type
: Animal Study, Human In Vitro
Additional Links
Substances
:
Ginsenosides
Diseases
:
Osteoarthritis
Pharmacological Actions
:
Chondroprotective
,
Cyclooxygenase 2 Inhibitors
,
Matrix Metalloproteinase-13 (MMP-13) Inhibitor
,
Prostaglandin PGE2 downregulation
[+]
Melatonin as a novel selective ATF-6 inhibitor can sensitize human hepatoma cells to ER stress inducing apoptosis.
Feb 13, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: World J Gastroenterol. 2017 Feb 14 ;23(6):986-998. PMID:
28246472
Article Published Date
: Feb 13, 2017
Study Type
: Human In Vitro
Additional Links
Substances
:
Melatonin
Diseases
:
Liver Cancer
Pharmacological Actions
:
Apoptotic
,
Cyclooxygenase 2 Inhibitors
[+]
Melatonin is a potential candidate compound for the treatment of proinflammatory disorders.
Aug 31, 2012
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2012 Sep ;53(2):154-65. Epub 2012 Feb 21. PMID:
22348531
Article Published Date
: Aug 31, 2012
Study Type
: Human In Vitro
Additional Links
Substances
:
Melatonin
Diseases
:
Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
NF-kappaB Inhibitor
,
Nitric Oxide Inhibitor
,
Prostaglandin PGE2 downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Dose Response
[+]
Oleuropein might provide a basis for developing a new dietary strategy for the prevention and management of rheumatoid arthritis.
Apr 19, 2017
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2017 Apr 20. Epub 2017 Apr 20. PMID:
28426090
Article Published Date
: Apr 19, 2017
Study Type
: Human In Vitro
Additional Links
Substances
:
Oleuropein
Diseases
:
Rheumatoid Arthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
Matrix metalloproteinase-1 (MMP-1) inhibitor
,
Matrix metalloproteinase-3 (MMP-3) inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Phloretin inhibits interleukin-1β-induced COX-2 and ICAM-1 in human lung epithelial cells.
May 31, 2015
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2015 Jun ;6(6):1960-7. PMID:
25996641
Article Published Date
: May 31, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Phloretin
Diseases
:
Experimental Lung Inflammation
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Interleukin-8 downregulation
,
Prostaglandin PGE2 downregulation
[+]
Resveratrol functions as a suppressor of particulate matter induced inflammatory signalling pathways.
May 07, 2017
Click here to read the entire abstract
Pubmed Data
: Int J Biochem Cell Biol. 2017 May 8 ;88:113-123. Epub 2017 May 8. PMID:
28495310
Article Published Date
: May 07, 2017
Study Type
: Human In Vitro
Additional Links
Substances
:
Resveratrol
Diseases
:
Air Pollution Linked Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Postaglandin PGE2 downregulation
[+]
Berberin inhibited colorectal cancer invasion and metastasis via down regulation of COX-2/PGE2- JAK2/STAT3 signaling pathway.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(5):e0123478. Epub 2015 May 8. PMID:
25954974
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Anti-metastatic
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Prostaglandin PGE2 downregulation
[+]
"Chrysin abrogates early hepatocarcinogenesis and induces apoptosis in N-nitrosodiethylamine-induced preneoplastic nodules in rats."
Feb 15, 2011
Click here to read the entire abstract
Pubmed Data
: Toxicol Appl Pharmacol. 2011 Feb 15 ;251(1):85-94. Epub 2010 Dec 15. PMID:
21167192
Article Published Date
: Feb 15, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Flavonoids
Diseases
:
Liver Cancer: Prevention
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
,
Cyclooxygenase 2 Inhibitors
,
Tumor Suppressor Protein p53 Upregulation
[+]
18β-Glycyrrhetinic acid significantly attenuated H. pylori-infected gastritis in gerbils.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Res Int. 2016 ;2016:4943793. Epub 2016 Feb 24. PMID:
27006947
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
18β-Glycyrrhetinic Acid
Diseases
:
Helicobacter Pylori Infection
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Gastroprotective
,
Interleukin-1 beta downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
5-FU and thymoquinone combination therapy resulted in a more significant reduction on AOM-induced colorectal tumors.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Drug Des Devel Ther. 2016 ;10:2239-53. Epub 2016 Jul 11. PMID:
27468227
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Thymoquinone
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Chemoprotective Agents
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
,
Wnt/β-catenin signaling pathway modulation
Additional Keywords
:
Chemothapeutic Synergy: 5-flourouracil
,
Gene Expression Regulation
[+]
6-gingerol prevented DSS-induced chronic ulcerative colitis via anti-inflammatory and antioxidative mechanisms.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: Hum Exp Toxicol. 2018 Jan 1:960327117751235. Epub 2018 Jan 1. PMID:
29350052
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Gingerol
Diseases
:
Ulcerative Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
[+]
A Burdock extract was able to reduce intestinal inflammation in an acute TNBS-induced experimental model of colitis in rats.
Mar 06, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Ethnopharmacol. 2013 Mar 7 ;146(1):300-10. Epub 2013 Jan 10. PMID:
23313393
Article Published Date
: Mar 06, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Burdock
Diseases
:
Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Phytotherapy
,
Plant Extracts
[+]
A combination of ginger and peony root may prevent memory impairment in AD by inhibiting Aβ accumulation and inflammation in the brain.
Nov 29, 2015
Click here to read the entire abstract
Pubmed Data
: J Alzheimers Dis. 2015 Nov 30. Epub 2015 Nov 30. PMID:
26639976
Article Published Date
: Nov 29, 2015
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Ginger
,
Peony
Diseases
:
Alzheimer's Disease
,
Brain Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Plant Extracts
[+]
A polyphenol-rich cranberry extract reverses insulin resistance and hepatic steatosis independently of body weight loss.
Nov 30, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Metab. 2017 Dec ;6(12):1563-1573. Epub 2017 Oct 18. PMID:
29107524
Article Published Date
: Nov 30, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Cranberry
Diseases
:
Insulin Resistance
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Plant Extracts
[+]
Açaí demonstrated protective effects against AOM/DSS-induced colon carcinogenesis.
Mar 14, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Gut Liver. 2017 Mar 15 ;11(2):243-252. PMID:
27965474
Article Published Date
: Mar 14, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Acai
Diseases
:
Colon Cancer
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Adlay bran ethanolic extract suppressed 1,2-dimethylhydrazine-indued preneoplastic lesions of the colon.
Jul 13, 2010
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2010 Jul 14 ;58(13):7616-23. PMID:
20536243
Article Published Date
: Jul 13, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Adlay
Diseases
:
Colon Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Plant Extracts
[+]
Allylmethylsulfide (AMS), a volatile organosulfur derivative from garlic has radioprotective properties.
Jun 01, 2009
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2009 Jun;12(3):542-51. PMID:
19627202
Article Published Date
: Jun 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Garlic
Diseases
:
Lipid Peroxidation
,
Radiation Induced Illness
Pharmacological Actions
:
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Radioprotective
,
Vascular Cell Adhesion Molecule-1 Inhibitor
Additional Keywords
:
Plant Extracts
[+]
Alpha linolenic fatty acid supplementation had a beneficial effect on tumor cell proliferation and cachexia parameters.
May 25, 2015
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2015 May 26:1-8. Epub 2015 May 26. PMID:
26011096
Article Published Date
: May 25, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Alpha Linolenic Acid
Diseases
:
Breast Cancer
,
Cachexia
Pharmacological Actions
:
Antiproliferative
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
American ginseng prevents and treats Ulcerative Colitis.
Sep 18, 2008
Click here to read the entire abstract
Pubmed Data
: Carcinogenesis. 2008 Sep 18. [Epub ahead of print] PMID:
18802031
Article Published Date
: Sep 18, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Ginseng (American)
Diseases
:
Colitis: Pseudomembranous
,
Ulcerative Colitis
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Nitric Oxide Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
[+]
Antarctic krill oil diet protects against lipopolysaccharide-induced oxidative stress, neuroinflammation and cognitive impairment.
Nov 27, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2017 Nov 28 ;18(12). Epub 2017 Nov 28. PMID:
29182579
Article Published Date
: Nov 27, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Krill
Diseases
:
Alzheimer's Disease
,
Brain: Oxidative Stress
,
Brain Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Neuroprotective Agents
[+]
Anthocyanin-rich fractions from red raspberries attenuate inflammation both in vitro and in vivo.
Dec 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2014 ;4:6234. Epub 2014 Aug 29. PMID:
25167935
Article Published Date
: Dec 31, 2013
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Anthocyanins
,
Raspberry
Diseases
:
Colitis
,
Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
Additional Keywords
:
Plant Extracts
[+]
Anthocyanins from black chokeberry delayed aging-related degenerative changes of the brain.
Jul 25, 2017
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2017 Jul 26 ;65(29):5973-5984. Epub 2017 Jul 12. PMID:
28657734
Article Published Date
: Jul 25, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Anthocyanins
,
Chokeberry
Diseases
:
Aging: Brain
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Plant Extracts
[+]
Anti-inflammatory mechanisms could be involved in pomegranate-mediated prevention of breast cancer.
Apr 27, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2017 Apr 28 ;9(5). Epub 2017 Apr 28. PMID:
28452959
Article Published Date
: Apr 27, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Pomegranate
Diseases
:
Breast Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
Heat Shock Protein Down-Regulation
[+]
Antrodia camphorata extract, when combined with anti-tumor agents, showed adjuvant antiproliferative effects on multi-drug resistant hepatoma.
Aug 13, 2008
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2008 Aug 13;118(3):387-95. Epub 2008 May 7. PMID:
18571350
Article Published Date
: Aug 13, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Antrodia camphorata
Diseases
:
Cancers: Multi-Drug Resistant
,
Liver Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Cell cycle arrest
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Plant Extracts
[+]
Apigenin and myricetin exhibited a protective and promising preventive strategy against cisplatin-induced nephrotoxicity.
Nov 30, 2017
Click here to read the entire abstract
Pubmed Data
: Pharm Biol. 2017 Dec ;55(1):766-774. PMID:
28064632
Article Published Date
: Nov 30, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Apigenin
,
Flavonoids
,
Myricetin
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
,
Oxidative Stress
Pharmacological Actions
:
Chemoprotective Agents
,
Cyclooxygenase 1 Inhibitor
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
Malondialdehyde Down-regulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Apigenin, a dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation in mice.
Jan 01, 2009
Click here to read the entire abstract
Pubmed Data
: Arthritis Res Ther. 2009;11(2):R59. Epub 2009 Apr 30. PMID:
19405952
Article Published Date
: Jan 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Apigenin
Diseases
:
Autoimmune Diseases
,
Lupus Erythematosus: Systemic
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
[+]
Apple polyphenols extract (APE) improves colon damage in a rat model of colitis.
Feb 28, 2012
Click here to read the entire abstract
Pubmed Data
: Dig Liver Dis. 2012 Feb 28. Epub 2012 Feb 28. PMID:
22381211
Article Published Date
: Feb 28, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Apple Polyphenols
Diseases
:
Colitis
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Apples rich polyphenols reduce colonic inflammation in rats.
Dec 01, 2009
Click here to read the entire abstract
Pubmed Data
: Br J Nutr. 2009 Dec;102(11):1620-8. Epub 2009 Jul 22. PMID:
19622193
Article Published Date
: Dec 01, 2009
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Apples
,
Flavonoids
,
Polyphenols
Diseases
:
Inflammatory Bowel Diseases
,
Irritable Bowel Syndrome
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
[+]
Arctigenin exerts protective effects against myocardial infarction.
Feb 28, 2018
Click here to read the entire abstract
Pubmed Data
: Mol Med Rep. 2018 Mar ;17(3):4839-4845. Epub 2018 Jan 10. PMID:
29328478
Article Published Date
: Feb 28, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Arctigenin
Diseases
:
Myocardial Infarction
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Heme oxygenase-1 up-regulation
Additional Keywords
:
Anti-Inflammatory Agents
,
Antioxidants
,
Arctigenin
,
Myocardial Infarction
[+]
Arginine reverses ethanol-induced inflammatory and fibrotic changes in liver despite continued ethanol administration.
Dec 01, 2001
Click here to read the entire abstract
Pubmed Data
: J Pharmacol Exp Ther. 2001 Dec;299(3):832-9. PMID:
11714866
Article Published Date
: Dec 01, 2001
Study Type
: Animal Study
Additional Links
Substances
:
Arginine
Diseases
:
Alcoholic Liver Disease
,
Inflammation
,
Liver Fibrosis
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Artemisia extracts were mucoprotective by attenuating stress related mucosal damages.
Feb 28, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Clin Biochem Nutr. 2015 Mar ;56(2):132-42. Epub 2014 Nov 28. PMID:
25759519
Article Published Date
: Feb 28, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Artemisia asiatica
Diseases
:
Gastrointestinal Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Gastroprotective
,
Nrf2 activation
Additional Keywords
:
Dose Response
[+]
Ascorbic acid contributes to the reduction of oxidative stress and inflammatory response in DSS-induced colitis.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Clin Exp Med. 2015 ;8(11):20245-53. Epub 2015 Nov 15. PMID:
26884937
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Gastrointestinal Inflammation
,
Ulcerative Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Superoxide Dismutase Up-regulation
[+]
Astaxanthin could be a promising agent for atopic dermatitis by inhibition of NF-κB signalling.
Sep 07, 2017
Click here to read the entire abstract
Pubmed Data
: Exp Dermatol. 2017 Sep 8. Epub 2017 Sep 8. PMID:
28887839
Article Published Date
: Sep 07, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Astaxanthin
Diseases
:
Atopic Dermatitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Astaxanthin exhibits anti-inflammatory and anti-cancer activity in a rat model of colon cnacer.
Apr 01, 2011
Click here to read the entire abstract
Pubmed Data
: Invest New Drugs. 2011 Apr;29(2):207-24. Epub 2009 Oct 30. PMID:
19876598
Article Published Date
: Apr 01, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Astaxanthin
Diseases
:
Cancer Metastasis
,
Colon Cancer
,
Colorectal Cancer
,
Inflammation
Pharmacological Actions
:
Apoptotic
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
[+]
Astaxanthin had an anti-depressant effect on diabetic mice.
Dec 21, 2016
Click here to read the entire abstract
Pubmed Data
: Brain Res. 2016 Dec 22. Epub 2016 Dec 22. PMID:
28017669
Article Published Date
: Dec 21, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Astaxanthin
Diseases
:
Brain Inflammation
,
Depression
,
Diabetic Complications
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antidepressive Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Prophylactic Agents
[+]
Astragaloside IV protects rat gastric mucosa against aspirin-induced damage.
Nov 30, 2016
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2016 Dec ;41:47-55. Epub 2016 Nov 2. PMID:
27816726
Article Published Date
: Nov 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Astragaloside
Diseases
:
Aspirin-Induced Toxicity
,
Gastric Ulcer
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Cyclooxygenase 1 Inhibitor
,
Cyclooxygenase 2 Inhibitors
,
Gastroprotective
,
Superoxide Dismutase Up-regulation
Problem Substances
:
Aspirin
[+]
Astragaloside IV suppresses inflammatory mediator production in synoviocytes and collagen‑induced arthritic rats.
Mar 31, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Med Rep. 2016 Apr ;13(4):3289-96. Epub 2016 Feb 22. PMID:
26936538
Article Published Date
: Mar 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Astragaloside
Diseases
:
Arthritis
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
[+]
Atractylodes macrocephala or Taraxacum herba extracts can be considered natural agents that can prevent inflammatory bowel disease relapse.
Sep 14, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Gut Liver. 2017 Sep 15 ;11(5):655-666. PMID:
28651306
Article Published Date
: Sep 14, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Bai Zhu
,
Dandelion
Diseases
:
Colitis
,
Inflammatory Bowel Diseases
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Heme oxygenase-1 up-regulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Plant Extracts
,
Risk Reduction
,
Superiority of Natural Substances versus Drugs
[+]
Barley sprouts have a protective effect against alcohol-induced liver injury.
Jul 20, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2016 Jul 21 ;8(7). Epub 2016 Jul 21. PMID:
27455313
Article Published Date
: Jul 20, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Barley
Diseases
:
Alcohol Toxicity
,
Chemically-Induced Liver Damage
,
Lipopolysaccharide-Induced Toxicity
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Hepatoprotective
Additional Keywords
:
Plant Extracts
[+]
Benzyl isothiocyanate and sulforaphane protect against initiation of pancreatic carcinogenesis in hamsters.
Sep 28, 2006
Click here to read the entire abstract
Pubmed Data
: Cancer Lett. 2006 Sep 28;241(2):275-80. Epub 2006 Jan 4. PMID:
16386831
Article Published Date
: Sep 28, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Benzyl isothiocyanate
,
Sulforaphane
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Isothiocyanates
,
Stilbenes
[+]
Berberine chloride ameliorates oxidative stress, inflammation and apoptosis in the pancreas of Streptozotocin induced diabetic rats.
Aug 22, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Aug 23 ;95:175-185. Epub 2017 Aug 23. PMID:
28843149
Article Published Date
: Aug 22, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Hypoglycemic Agents
,
NF-kappaB Inhibitor
,
Pancreato Protective Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Diabetes Mellitus: Type 1
[+]
Berberine has a preventive effect on experimental colon cancer.
Oct 01, 2010
Click here to read the entire abstract
Pubmed Data
: Zhongguo Zhong Yao Za Zhi. 2010 Oct;35(20):2768-73. PMID:
21246838
Article Published Date
: Oct 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Colon Cancer
Pharmacological Actions
:
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
[+]
Beta-caryophyllene constitutes an alluring therapeutic molecule towards the treatment of multiple sclerosis.
Mar 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2017 Apr 1 ;18(4). Epub 2017 Apr 1. PMID:
28368293
Article Published Date
: Mar 31, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Beta-Caryophyllene
Diseases
:
Inflammation: Brain
,
Multiple Sclerosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Immunomodulatory
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
Additional Keywords
:
Cannabinoid Receptors
[+]
Black Adzuki bean attenuates high-fat diet-induced colon inflammation.
Mar 31, 2017
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2017 Apr ;20(4):367-375. PMID:
28406732
Article Published Date
: Mar 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Aduki bean
Diseases
:
Colitis
,
High Fat Diet
,
Inflammation
,
Lipopolysaccharide-Induced Toxicity
,
Obesity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Plant Extracts
[+]
Boswellia serrate extract has great potential to suppress colon tumorigenesis.
Feb 27, 2017
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2017 Feb 28. Epub 2017 Feb 28. PMID:
28245338
Article Published Date
: Feb 27, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Frankincense
Diseases
:
Colon Cancer
,
Colon Cancer: Prevention
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
[+]
Boswellic acid suppresses growth and metastatis of human pancreatic tumors (nude mouse model).
Jan 01, 2011
Click here to read the entire abstract
Pubmed Data
: PLoS One. 2011 ;6(10):e26943. Epub 2011 Oct 31. PMID:
22066019
Article Published Date
: Jan 01, 2011
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Boswellia
Diseases
:
Cancer Metastasis
,
Pancreatic Cancer
Pharmacological Actions
:
Anti-metastatic
,
Apoptotic
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
[+]
Both indole-3-carbinol and myo-inositol inhibit the development of vinyl carbamate induced pulmonary adenocarcinoma in mice.
Jan 31, 2010
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Carcinogenesis. 2010 Feb ;31(2):239-45. Epub 2009 Jul 22. PMID:
19625346
Article Published Date
: Jan 31, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Indole-3-Carbinol
,
Myo-inositol
Diseases
:
Lung Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
,
Cyclooxygenase 2 Inhibitors
Problem Substances
:
Vinyl Carbamate
[+]
C. obtusa essential oil may constitute a novel source of anti-inflammatory treatments.
Jun 30, 2013
Click here to read the entire abstract
Pubmed Data
: Mol Med Rep. 2013 Jul ;8(1):255-9. Epub 2013 May 8. PMID:
23652412
Article Published Date
: Jun 30, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Japanese cypress
Diseases
:
Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Plant Oils
[+]
Caffeic acid phenethyl ester, a compound found within propolis causes regression of experimental endometriosis.
Apr 01, 2007
Click here to read the entire abstract
Pubmed Data
: Reprod Sci. 2007 Apr;14(3):270-9. PMID:
17636241
Article Published Date
: Apr 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Bee Propolis
,
Caffeic acid phenethyl ester
Diseases
:
Endometriosis
Pharmacological Actions
:
Antioxidants
,
Cyclooxygenase 2 Inhibitors
[+]
Camel milk attenuates rheumatoid arthritis in animals.
Sep 19, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Physiol Biochem. 2017 Sep 20 ;43(2):540-552. Epub 2017 Sep 20. PMID:
28930753
Article Published Date
: Sep 19, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Camel Milk
Diseases
:
Rheumatoid Arthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-10 upregulation
,
NF-kappaB Inhibitor
,
Nitric Oxide Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Cannabidiol could be used to prevent experimental colitis in mice.
Oct 31, 2009
Click here to read the entire abstract
Pubmed Data
: J Mol Med (Berl). 2009 Nov ;87(11):1111-21. Epub 2009 Aug 20. PMID:
19690824
Article Published Date
: Oct 31, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
Diseases
:
Colitis
Pharmacological Actions
:
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-10 downregulation
,
Interleukin-1 beta downregulation
[+]
Carrot seeds contain phytochemicals capable of inhibiting inflammatory enzymes.
Jun 01, 2007
Click here to read the entire abstract
Pubmed Data
: Carcinogenesis. 2007 Jun;28(6):1188-96. Epub 2006 Dec 6. PMID:
13680840
Article Published Date
: Jun 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Carrot
Pharmacological Actions
:
Cyclooxygenase 1 Inhibitor
,
Cyclooxygenase 2 Inhibitors
,
Cyclooxygenase Inhibitors
[+]
Carvacrol can be used as a protective agent against benzo(a)pyrene-induced lung toxicity and inflammation.
Dec 31, 2016
Click here to read the entire abstract
Pubmed Data
: Hum Exp Toxicol. 2017 Jan 1:960327117735572. Epub 2017 Jan 1. PMID:
29019276
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Carvacrol
Diseases
:
Benzo[a]pyrene-induced Toxicity
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
Problem Substances
:
Benzo(a)pyrene
[+]
Chamaecyparis obtusa essential oil has anti-inflammatory and anti-nociceptive effects on arthritis in rats.
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: Biosci Biotechnol Biochem. 2015 ;80(1):203-9. Epub 2015 Aug 19. PMID:
26581235
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Japanese cypress
Diseases
:
Arthritis
Pharmacological Actions
:
Analgesics
,
Anti-Inflammatory Agents
,
Antinoceceptive
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Essential Oils
[+]
Chemopreventive effects of Eryngium foetidum L. leaves on COX-2 reduction in mice induced colorectal carcinogenesis.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2016 ;68(1):144-53. Epub 2016 Jan 15. PMID:
26771664
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Thistle
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Phytotherapy
[+]
Chinese skullcap (Scutellaria baicalensis) significantly improves functional recovery from spinal cord injury in rats by inhibiting inflammation and oxidative stress after injury.
Aug 01, 2009
Click here to read the entire abstract
Pubmed Data
: J Neurochem. 2009 Aug;110(4):1276-87. Epub 2009 Jun 10. PMID:
19519665
Article Published Date
: Aug 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Chinese Skullcap
Diseases
:
Brain: Microglial Activation
,
Spinal Cord Injuries
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Apoptotic
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Neuroprotective Agents
,
Nitric Oxide Inhibitor
Additional Keywords
:
Plant Extracts
[+]
Cocoa may merit further clinical investigation as a chemopreventive agent that helps prevent colitis-associated cancer.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biofactors. 2015 Jan-Feb;41(1):1-14. Epub 2014 Dec 24. PMID:
25545372
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Cocoa
Diseases
:
Colorectal Cancer
,
Colorectal Cancer: Prevention
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
Nrf2 activation
[+]
Cocoa polyphenols may inhibit tumor promotion through antioxidant and antiinflammatory mechanisms.
May 01, 2006
Click here to read the entire abstract
Pubmed Data
: J Nutr. 2006 May;136(5):1150-5. PMID:
16614396
Article Published Date
: May 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Flavonoids
,
Polyphenols
Diseases
:
Tumors
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
[+]
Combination of Pelargonium sidoides and Coptis chinensis root inhibits nuclear factor kappa B-mediated inflammatory responses.
Jan 18, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Complement Altern Med. 2018 Jan 19 ;18(1):20. Epub 2018 Jan 19. PMID:
29351747
Article Published Date
: Jan 18, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Coptis chinensis
,
Pelargonium sidoides
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Plant Extracts
[+]
COX2 expression in HPV16-induced lesions may be modulated by nutraceuticals.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: Anticancer Res. 2018 03 ;38(3):1461-1466. PMID:
29491072
Article Published Date
: Dec 31, 2017
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Curcumin
,
Rutin
Diseases
:
Human Papillomavirus (HPV)
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
[+]
Crocetin supplementation in the MCA mice also showed protection against cervical cancer.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Res Int. 2015 ;2015:829513. Epub 2015 Mar 22. PMID:
25874230
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Crocetin
Diseases
:
Cervical Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Crocin, a carotenoid fround within Gardenia jasminoides and Crocus sativus (Safron) has significant anti-inflammatory activity.
Sep 23, 2009
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2009 Sep 23;57(18):8325-30. PMID:
19754168
Article Published Date
: Sep 23, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Gardenia
,
Saffron
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Cyclooxygenase Inhibitors
,
Prostaglandin Antagonists
[+]
Curcumin ameliorates experimentally induced ulcerative colitis.
Mar 01, 2007
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2007 Mar;7(3):333-42. Epub 2006 Dec 18. PMID:
17276891
Article Published Date
: Mar 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Colitis
,
Ulcerative Colitis
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Curcumin attenuated glucose intolerance and insulin resistance through its antioxidant and anti-inflammatory effects.
Dec 19, 2015
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2015 Dec 20. Epub 2015 Dec 20. PMID:
26713546
Article Published Date
: Dec 19, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
C-Reactive Protein
,
Diabetes Mellitus: Type 2
,
Inflammation
,
Insulin Resistance
,
Obesity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Malondialdehyde Down-regulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Curcumin can enhance postsynaptic electrical reactivity and cell viability in intact neural circuits with antidepressant-like effects.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mediators Inflamm. 2017 ;2017:6280925. Epub 2017 Jan 11. PMID:
28167853
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Depression
Pharmacological Actions
:
Antidepressive Agents
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Antidepressive Agents
,
CURCUMIN
,
Cyclooxygenase 2 Inhibitors
,
depression
[+]
Curcumin has therapeutic effects in chemically-induced colitis.
Jun 28, 2006
Click here to read the entire abstract
Pubmed Data
: World J Gastroenterol. 2006 Jun 28;12(24):3848-53. PMID:
16804969
Article Published Date
: Jun 28, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Colitis
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Prostaglandin PGE2 downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Curcumin inhibits NF-kappaB activation and reduces the severity of experimental fatty liver in mice.
Dec 01, 2003
Click here to read the entire abstract
Pubmed Data
: Mech Ageing Dev. 2003 Dec;124(10-12):1025-34. PMID:
15582125
Article Published Date
: Dec 01, 2003
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Fatty Liver
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Enzyme Inhibitors
,
Hepatoprotective
,
NF-kappaB Inhibitor
[+]
Curcumin inhibits prostate cancer tumors.
Dec 01, 2009
Click here to read the entire abstract
Pubmed Data
: Peptides. 2009 Dec;30(12):2357-64. Epub 2009 Sep 20. PMID:
19772879
Article Published Date
: Dec 01, 2009
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Curcumin inhibits trinitrobenzene sulphonic acid-induced colitis in rats.
Aug 01, 2006
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2006 Aug;6(8):1233-42. Epub 2006 Apr 7. PMID:
16782535
Article Published Date
: Aug 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Colitis
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Prostaglandin PGE2 downregulation
[+]
Curcumin may have therapeutic value in colon cancer prevention.
Oct 28, 1999
Click here to read the entire abstract
Pubmed Data
: Oncogene. 1999 Oct 28;18(44):6013-20. PMID:
10557090
Article Published Date
: Oct 28, 1999
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Colon Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Cyclooxygenase 2 Inhibitors
,
Enzyme Inhibitors
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Curcumin might be useful in the chemoprevention of colorectal cancer in individuals consuming an high-protein diet.
Jul 31, 2015
Click here to read the entire abstract
Pubmed Data
: Nutr Res. 2015 Aug ;35(8):726-35. Epub 2015 Jun 1. PMID:
26094212
Article Published Date
: Jul 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Colorectal Cancer: Prevention
,
Gastrointestinal Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
Nitric Oxide Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Curcumin potentiated significant increase in Nrf2 activation. It restored activity of phase-II antioxidant enzymes like GST, GR, NQO1, and tumour suppressor p53 level.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(4):e0124000. Epub 2015 Apr 10. PMID:
25860911
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Liver Cancer
,
Liver Cancer: Prevention
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
MicroRNA modulator
,
Nrf2 activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Curcumin potentiates the antitumor effects of Bacillus Calmette-Guerin against bladder cancer.
Dec 01, 2009
Click here to read the entire abstract
Pubmed Data
: Cancer Res. 2009 Dec 1;69(23):8958-66. Epub 2009 Nov 10. PMID:
19903839
Article Published Date
: Dec 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Bladder Cancer
Pharmacological Actions
:
Apoptotic
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Vascular Endothelial Growth Factor A Inhibitor
Additional Keywords
:
Drug Synergy
[+]
Curcumin prevents colon carcinogenesis.
Apr 01, 1999
Click here to read the entire abstract
Pubmed Data
: Carcinogenesis. 1999 Apr;20(4):641-4. PMID:
10223193
Article Published Date
: Apr 01, 1999
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Colon Cancer
,
Colon Polyps
Pharmacological Actions
:
Anticarcinogenic Agents
,
Cyclooxygenase 2 Inhibitors
,
Enzyme Inhibitors
,
Nitric Oxide Inhibitor
[+]
Curcumin protects against necrotizing enterocolitis in neonatal rats.
Feb 01, 2010
Click here to read the entire abstract
Pubmed Data
: Zhongguo Dang Dai Er Ke Za Zhi. 2010 Feb;12(2):132-6. PMID:
20199731
Article Published Date
: Feb 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Infant Infections
,
Necrotising enterocolitis
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Interleukin-10 downregulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Curcumin reduces oxidative and nitrative DNA damage associated with fluke infection.
Oct 01, 2009
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2009 Oct;53(10):1316-28. PMID:
19753608
Article Published Date
: Oct 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
DNA damage
,
Flukes
,
Oxidative Stress
,
Parasitic Diseases
Pharmacological Actions
:
Antimutagenic Agents
,
Antiparasitic Agents
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
[+]
Curcumin retards the growth of intestinal polyps in a mouse model of familial adenomatous polyposis.
Feb 01, 2006
Click here to read the entire abstract
Pubmed Data
: Eur J Cancer. 2006 Feb;42(3):415-21. Epub 2006 Jan 4. PMID:
16387490
Article Published Date
: Feb 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Familial Adenomatous Polyposis
,
Intestinal Polyps
Pharmacological Actions
:
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
[+]
Curcumin reverses neurochemical, histological and immuno-histochemical alterations in the model of global brain ischemia.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Tradit Complement Med. 2017 Jan ;7(1):14-23. Epub 2016 Feb 11. PMID:
28053883
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Brain Ischemia
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Neuroprotective Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Curcumin works synergistically with paclitaxel to inhibit breast cancer cell metastasis to the lung in a mouse model.
Oct 15, 2005
Click here to read the entire abstract
Pubmed Data
: Clin Cancer Res. 2005 Oct 15;11(20):7490-8. PMID:
16243823
Article Published Date
: Oct 15, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Breast Cancer
,
Breast Cancer: Lung Metastasis
,
Lung Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Apoptotic
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
NF-kappaB Inhibitor
Additional Keywords
:
Drug: Paclitaxel
,
Drug-Plant-Vitamin Synergies
[+]
Cyanidin-3-O-glucoside exerts pulmonary protective effects on CLP-induced ALI rats.
Jun 11, 2015
Click here to read the entire abstract
Pubmed Data
: J Surg Res. 2015 Jun 12. Epub 2015 Jun 12. PMID:
26152793
Article Published Date
: Jun 11, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Cyanidin 3-glucoside
Diseases
:
Lung Injury: Acute
,
Sepsis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Malondialdehyde Down-regulation
,
Mitochondrial Superoxide Dismutase Upregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Daidzein attenuates abdominal aortic aneurysm through NF-κB, p38MAPK and TGF-β1 pathways.
Jun 30, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Med Rep. 2016 Jul ;14(1):955-62. Epub 2016 May 18. PMID:
27222119
Article Published Date
: Jun 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Daidzein
,
Isoflavones
Diseases
:
Aneurysm: Aortic
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Demethoxycurcumin may decrease COX-2 expression and improve endothelial function in hypertension.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2016 ;2016:9045736. Epub 2016 Dec 25. PMID:
28105253
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Demethoxycurcumin
Diseases
:
Endothelial Dysfunction
,
Hypertension
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
[+]
Dendrosomal curcumin has a chemoprotective effect on the breast cancer metastasis through suppression of NF-κB and its regulated gene products.
Jul 04, 2015
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2015 Jul 5 ;758:188-96. Epub 2015 Apr 8. PMID:
25863259
Article Published Date
: Jul 04, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Breast Cancer
,
Breast Cancer: Metastatic
Pharmacological Actions
:
Anti-metastatic
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
NF-kappaB Inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
[+]
Dietary administration of garcinol effectively reduced the tumor size and incidence in the mouse colon.
Aug 31, 2014
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2014 Sep ;58(9):1820-9. Epub 2014 Jul 1. PMID:
24981158
Article Published Date
: Aug 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Garcinia indica
Diseases
:
Colon Cancer
,
Colon Cancer: Prevention
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Chemopreventive
,
Cyclin D1 Down-Regulation
,
Cyclooxygenase 2 Inhibitors
,
Vascular Endothelial Growth Factor Inhibitors
[+]
Dietary astaxanthin inhibits colitis and colitis-associated colon carcinogenesis in mice.
May 20, 2011
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2011 May 20. Epub 2011 May 20. PMID:
21621527
Article Published Date
: May 20, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Astaxanthin
Diseases
:
Colitis
,
Colon Cancer
Pharmacological Actions
:
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
[+]
Dietary feeding of grape seed extract prevents intestinal tumorigenesis in mice.
Jan 01, 2010
Click here to read the entire abstract
Pubmed Data
: Neoplasia. 2010 Jan;12(1):95-102. PMID:
20072658
Article Published Date
: Jan 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Grape Seed Extract
Diseases
:
Intestinal Cancer
,
Intestinal Polyps
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cyclooxygenase 2 Inhibitors
[+]
Dietary flaxseed may be chemopreventive for intestinal and colon tumor development in mice possibly by increasing omega -3 fatty acid levels, lignans, and decreasing COX-1 and COX-2 levels.
Jan 01, 2009
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2009;61(2):276-83. PMID:
19235044
Article Published Date
: Jan 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Flaxseed
,
Lignans
,
Omega-3 Fatty Acids
Diseases
:
Colon Cancer
,
Intestinal Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Cyclooxygenase 1 Inhibitor
,
Cyclooxygenase 2 Inhibitors
,
Cyclooxygenase Inhibitors
[+]
Dietary flaxseed meal containing high levels of omega-3 fatty acids and lignans is effective in preventing colon tumor development when compared with dietary corn meal possibly by increasing omega-3 fatty acid levels and decreasing COX-1 and COX-2 levels.
Jan 01, 2006
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2006;54(2):216-22. PMID:
16898866
Article Published Date
: Jan 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Flaxseed
,
Lignans
,
Omega-3 Fatty Acids
Diseases
:
Colon Cancer
Pharmacological Actions
:
Cyclooxygenase 1 Inhibitor
,
Cyclooxygenase 2 Inhibitors
[+]
Dietary intake of pterostilbene, a constituent of blueberries, inhibits colon carcinogenesis in rats.
Jul 01, 2010
Click here to read the entire abstract
Pubmed Data
: Carcinogenesis. 2010 Jul;31(7):1272-8. Epub 2010 Jan 8. PMID:
20061362
Article Published Date
: Jul 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Blueberry
,
Pterostilbene
Diseases
:
Colon Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Stilbenes
[+]
Dietary saturated fatty acids down-regulate cyclooxygenase-2 and tumor necrosis factor alfa and reverse fibrosis in alcohol-induced liver disease in the rat.
Dec 01, 1997
Click here to read the entire abstract
Pubmed Data
: Hepatology. 1997 Dec;26(6):1538-45. PMID:
9397995
Article Published Date
: Dec 01, 1997
Study Type
: Animal Study
Additional Links
Substances
:
Medium Chain Triglycerides
,
Palm Oil
,
Saturated fatty acids
Diseases
:
Alcoholic Liver Disease
,
Liver Fibrosis
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Beneficial Saturated Fats
,
Disease Reversal
[+]
Dietary supplementation of resveratrol attenuates chronic colonic inflammation in mice.
Jan 01, 2010
Click here to read the entire abstract
Pubmed Data
: Asia Pac J Clin Nutr. 2010;19(1):142-50. PMID:
20132809
Article Published Date
: Jan 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Resveratrol
,
Stilbenes
Diseases
:
Inflammation
,
Ulcerative Colitis
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Nitric Oxide Inhibitor
,
P38 Mitogen-Activated Protein Kinase Modulator
,
Prostaglandin E Synthase-1 (PGES-1) Down-Regulation
[+]
Electroacupuncture was an effective analgesic and anti-inflammatory.
Oct 23, 2016
Click here to read the entire abstract
Pubmed Data
: Chin J Integr Med. 2016 Oct 24. Epub 2016 Aug 24. PMID:
27778263
Article Published Date
: Oct 23, 2016
Study Type
: Animal Study
Additional Links
Diseases
:
Neuropathic Pain
Therapeutic Actions
:
Electroacupuncture
Pharmacological Actions
:
Analgesics
,
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
[+]
Essential oils extracted from Chamaecyparis obtusa may be considered an effective therapeutic agent for the treatment of inflammatory diseases.
Mar 31, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Med Rep. 2016 Apr ;13(4):3335-41. Epub 2016 Feb 18. PMID:
26936418
Article Published Date
: Mar 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Japanese cypress
Diseases
:
Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Nitric Oxide Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Essential Oils
[+]
Evening primrose oil ameliorates platelet aggregation and improves cardiac recovery in myocardial-infarct hypercholesterolemic rats.
Dec 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Physiol Pathophysiol Pharmacol. 2014 ;6(1):23-36. Epub 2014 Mar 13. PMID:
24665356
Article Published Date
: Dec 31, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Evening Primrose Oil
Diseases
:
Myocardial Infarction
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cardioprotective
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Extracts of R. officinalis and rosmarinic acid through modulating neuro-inflammation might be potential candidates in treating neuropathic pain.
Dec 21, 2016
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2016 Dec 22 ;86:441-449. Epub 2016 Dec 22. PMID:
28012923
Article Published Date
: Dec 21, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Rosemary
,
Rosmarinic acid
Diseases
:
Brain Inflammation
,
Neuropathic Pain
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Nitric Oxide Inhibitor
,
Prostaglandin PGE2 downregulation
Additional Keywords
:
Plant Extracts
[+]
Fermented brown rice and rice bran have a chemopreventive effect on inflammation-related colorectal carcinogenesis in mice.
Jan 01, 2010
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2010 Jan;23(1):53-9. PMID:
19956864
Article Published Date
: Jan 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Brown Rice
,
Fermented Foods and Beverages
,
Rice Bran
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
[+]
Fermented C. longa might be a useful material for preventing impairment of learning and memory.
Jul 16, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Complement Altern Med. 2017 Jul 17 ;17(1):367. Epub 2017 Jul 17. PMID:
28716085
Article Published Date
: Jul 16, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Turmeric: Fermented
Diseases
:
Cognitive Decline/Dysfunction
,
Memory Disorders
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Neuroprotective Agents
,
Nitric Oxide Inhibitor
,
Postaglandin PGE2 downregulation
[+]
Fisetin may be a potential agent in the treatment of osteoarthritis.
Feb 13, 2017
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2017 Feb 14 ;45:135-147. Epub 2017 Feb 14. PMID:
28213268
Article Published Date
: Feb 13, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Fisetin
Diseases
:
Osteoarthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Matrix Metalloproteinase-13 (MMP-13) Inhibitor
,
Matrix metalloproteinase-3 (MMP-3) inhibitor
,
Prostaglandin PGE2 downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Fucoidan exhibits a gastro-protective effect against aspirin-induced ulceration in rats.
Jan 31, 2011
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2011 Feb ;11(2):157-63. Epub 2010 Nov 26. PMID:
21084063
Article Published Date
: Jan 31, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Fucoidan
Diseases
:
Aspirin-Induced Toxicity
,
Gastric Ulcer
Pharmacological Actions
:
Anti-Ulcer Agents
,
Cyclooxygenase 1 Inhibitor
,
Cyclooxygenase 2 Inhibitors
,
Epidermal growth factor receptor (EGFR) inhibitor
Problem Substances
:
Aspirin
Adverse Pharmacological Actions
:
Ulcerogenic
[+]
Fucoxanthin may have therapeutic potential as a treatment for patients with inflammatory diseases.
Sep 28, 2015
Click here to read the entire abstract
Pubmed Data
: J Biochem Mol Toxicol. 2015 Sep 29. Epub 2015 Sep 29. PMID:
26418808
Article Published Date
: Sep 28, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Fucoxanthin
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
[+]
Genipin inhibits allergic responses in ovalbumin-induced asthmatic mice.
Nov 30, 2017
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2017 Dec ;53:49-55. Epub 2017 Oct 15. PMID:
29035815
Article Published Date
: Nov 30, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Genipin
Diseases
:
Asthma
Pharmacological Actions
:
Anti-Asthmatic Agents
,
Cyclooxygenase 2 Inhibitors
,
interleukin-13 down-regulation
,
Interleukin-5 downregulation
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Geniposide and genipin have a healthy promotion to eradicate H. pylori infections.
Nov 30, 2017
Click here to read the entire abstract
Pubmed Data
: J Food Sci. 2017 Dec ;82(12):3021-3028. Epub 2017 Nov 14. PMID:
29135040
Article Published Date
: Nov 30, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Genipin
Diseases
:
Helicobacter Pylori Infection
Pharmacological Actions
:
Anti-Bacterial Agents
,
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interferon Gamma Reducer
,
Interleukin-1 beta downregulation
[+]
Geraniol attenuates 4NQO-induced tongue carcinogenesis through downregulating the activation of NF-κB in rats.
Sep 30, 2017
Click here to read the entire abstract
Pubmed Data
: Mol Cell Biochem. 2017 Oct ;434(1-2):7-15. Epub 2017 Apr 10. PMID:
28397014
Article Published Date
: Sep 30, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Geraniol
Diseases
:
Tongue Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Geraniol could be a powerful treatment of intestinal inflammation and dysbiosis.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2016 ;7:38. Epub 2016 Mar 3. PMID:
26973525
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Geraniol
Diseases
:
Colitis
,
Dysbiosis
,
Gastrointestinal Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
[+]
Ginger inhibits micoglial cell activiation associated with brain inflammation.
Jun 01, 2009
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2009 Jun;47(6):1190-7. Epub 2009 Feb 20. PMID:
19233241
Article Published Date
: Jun 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Ginger
Diseases
:
Brain: Microglial Activation
,
Brain Inflammation
,
Inflammation
,
Lipopolysaccharide-Induced Toxicity
,
Neurodegenerative Diseases
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Nitric Oxide Inhibitor
,
Prostaglandin Antagonists
[+]
Gingerol could protect against experimental liver fibrosis in rats.
Jan 25, 2016
Click here to read the entire abstract
Pubmed Data
: Naunyn Schmiedebergs Arch Pharmacol. 2016 Jan 26. Epub 2016 Jan 26. PMID:
26809353
Article Published Date
: Jan 25, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Gingerol
Diseases
:
Chemically-Induced Liver Damage
,
Liver Fibrosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Hepatoprotective
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Ginkgetin may be beneficial against chronic skin inflammatory disorders like atopic dermatitis.
Apr 30, 2006
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biol Pharm Bull. 2006 May ;29(5):1046-9. PMID:
16651744
Article Published Date
: Apr 30, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Ginkgo biloba
Diseases
:
Atopic Dermatitis
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
[+]
Ginkgo biloba extract anti-inflammatory properties and ameliorates colitis in mice.
Sep 01, 2008
Click here to read the entire abstract
Pubmed Data
: Carcinogenesis. 2008 Sep;29(9):1799-806. Epub 2008 Jun 20. PMID:
18567620
Article Published Date
: Sep 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Ginkgo biloba
Diseases
:
Colitis
,
Inflammation
Pharmacological Actions
:
Antioxidants
,
Apoptotic
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Plant Extracts
[+]
Ginkgo biloba extract protects against aging-associated mitochondrial dysfunction in platelets and hippocampi of mice.
Jan 01, 2010
Click here to read the entire abstract
Pubmed Data
: Platelets. 2010;21(5):373-9. PMID:
20459350
Article Published Date
: Jan 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Ginkgo biloba
Diseases
:
Aging
,
Aging: Brain
,
Mitochondrial Dysfunction
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Neuroprotective Agents
Additional Keywords
:
Plant Extracts
[+]
Ginsenosides from the leaves of Panax quinquefolius ameliorated acetaminophen-induced hepatotoxicity in mice.
May 09, 2017
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2017 May 10 ;65(18):3684-3692. Epub 2017 Apr 25. PMID:
28429935
Article Published Date
: May 09, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Acetaminophen (Tylenol) Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Hepatoprotective
,
Malondialdehyde Down-regulation
Problem Substances
:
Acetaminophen
,
Paracetamol
[+]
Graviola possesses analgesic effects through interaction with opioidergic pathway and anti-inflammatory properties through inhibition of chemical mediators of inflammation.
Nov 30, 2014
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2014 Dec ;17(12):1375-82. PMID:
25133801
Article Published Date
: Nov 30, 2014
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Graviola
Diseases
:
Arthritis
,
Rheumatism
Pharmacological Actions
:
Analgesics
,
Anti-Inflammatory Agents
,
Cyclooxygenase 1 Inhibitor
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Natural Substances Versus Drugs
Problem Substances
:
Carrageenan
[+]
Hispolon could be useful in the treatment of breast cancers or other gynecologic diseases.
Dec 31, 2016
Click here to read the entire abstract
Pubmed Data
: Int J Med Mushrooms. 2017 ;19(3):233-242. PMID:
28605338
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Medicinal Mushrooms
Diseases
:
Breast Cancer
Pharmacological Actions
:
Aromatase Inhibitors
,
Cyclooxygenase 2 Inhibitors
[+]
Honokiol has the ability to inhibit UVB-induced immunosuppression in preclinical model.
May 09, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2017 May 10 ;7(1):1657. Epub 2017 May 10. PMID:
28490739
Article Published Date
: May 09, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Honokiol
Diseases
:
Skin Cancer: Prevention
,
Ultraviolet Radiation Induced Damage
Pharmacological Actions
:
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
Immunomodulatory
,
Postaglandin PGE2 downregulation
[+]
Hops (H. lupulus) has anti-inflammatory activity in a mouse model of athritis.
Jul 16, 1996
Click here to read the entire abstract
Pubmed Data
: Biochem Biophys Res Commun. 1996 Jul 16;224(2):358-61. PMID:
16534727
Article Published Date
: Jul 16, 1996
Study Type
: Animal Study
Additional Links
Substances
:
Hops
Diseases
:
Arthritis
,
Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Postaglandin PGE2 downregulation
Additional Keywords
:
Plant Extracts
[+]
Isoliquiritigenin has a protective effect against carbon tetrachloride-induced liver damage.
Jan 04, 2015
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2015 Jan 5 ;225:13-20. Epub 2014 Nov 6. PMID:
25450236
Article Published Date
: Jan 04, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Isoliquiritigenin
Diseases
:
Chemically-Induced Liver Damage
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Enzyme Inhibitors
,
Hepatoprotective
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Isoquercitrin may be effective in the prevention of acute colitis.
Nov 30, 2016
Click here to read the entire abstract
Pubmed Data
: Pharmacol Rep. 2016 Dec ;68(6):1197-1204. Epub 2016 Sep 19. PMID:
27657482
Article Published Date
: Nov 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Isoquercitrin
Diseases
:
Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
[+]
Korean Red Ginseng extracts exhibited anti-inflammatory effects by ameliorating the symptoms of gastric ulcer in a gastritis mouse model.
Sep 30, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Ginseng Res. 2016 Oct ;40(4):437-444. Epub 2016 Aug 24. PMID:
27746698
Article Published Date
: Sep 30, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Ginseng (Korean)
Diseases
:
Gastric Ulcer
,
Gastritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Gastrointestinal Agents
,
Gastroprotective
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Lactobacillus fermentum HY01 had significant preventive effects in dextran sulfate sodium induced-colitis.
May 24, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2017 May 25 ;9(6). Epub 2017 May 25. PMID:
28587089
Article Published Date
: May 24, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Lactobacillus fermentum
Diseases
:
Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interferon Gamma Reducer
,
Interleukin-12 downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Lactobacillus fermentum IM12 attenuates inflammation in mice.
May 29, 2017
Click here to read the entire abstract
Pubmed Data
: Benef Microbes. 2017 May 30 ;8(3):407-419. Epub 2017 May 15. PMID:
28504577
Article Published Date
: May 29, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Lactobacillus fermentum
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
[+]
Lactobacillus paracasei GMNL-32 exerts a therapeutic effect on cardiac abnormalities in mice.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2017 ;12(9):e0185098. Epub 2017 Sep 21. PMID:
28934296
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Lactobacillus paracasei
Diseases
:
Cardiovascular Disease
,
Lupus Erythematosus: Systemic
Pharmacological Actions
:
Anti-Apoptotic
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
LED therapy provides an analgesic effect and modifies the expression of COX-2, PGE2, and proinflammatory cytokines in incised skin.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Pain Res Manag. 2017 ;2017:4792489. Epub 2017 Apr 2. PMID:
28469528
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Diseases
:
Wound Healing
Therapeutic Actions
:
Light-Emitting Diodes (LEDs) Therapy
Pharmacological Actions
:
Analgesics
,
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Postaglandin PGE2 downregulation
[+]
Lion's mane has antitumor effects in tumor-bearing mice.
Sep 28, 2011
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2011 Sep 28 ;59(18):9861-9. Epub 2011 Aug 25. PMID:
21846141
Article Published Date
: Sep 28, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Lion's Mane (Hericium Erinaceus)
Diseases
:
Colon Cancer
,
Low Immune Function: Natural Killer Cells
,
Tumors
Pharmacological Actions
:
5-Lipoxygenase Inhibitor
,
Anti-Angiogenic
,
Antineoplastic Agents
,
Cyclooxygenase 2 Inhibitors
,
Vascular Endothelial Growth Factor Inhibitors
[+]
Lupeol acetate significantly improves the symptoms of RA by down-regulating expressions of inflammatory cytokines and osteoclastogenesis.
Mar 31, 2016
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2016 Apr ;79:231-40. Epub 2016 Mar 11. PMID:
27044833
Article Published Date
: Mar 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Lupeol
Diseases
:
Arthritis
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Dose Response
[+]
L‑carnitine ameliorated liver inflammation and serum pro‑inflammatory markers in cancer cachexia.
Dec 03, 2015
Click here to read the entire abstract
Pubmed Data
: Mol Med Rep. 2015 Dec 4. Epub 2015 Dec 4. PMID:
26647854
Article Published Date
: Dec 03, 2015
Study Type
: Animal Study
Additional Links
Substances
:
L-Carnitine
Diseases
:
Cachexia: Cancer
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
Prostaglandin PGE2 downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
M. oleifera containing Vicenin-2 active compound may accelerate wound healing in hyperglycemic conditions.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Drug Des Devel Ther. 2016 ;10:1715-30. Epub 2016 May 24. PMID:
27307703
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Moringa oleifera
Diseases
:
Diabetic Complications
,
Wound Healing: Delayed
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Mangiferin is potent anti-inflammatory compound that reduces inflammation.
Feb 19, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2017 Feb 20 ;7:42683. Epub 2017 Feb 20. PMID:
28218280
Article Published Date
: Feb 19, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Mangiferin
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Melatonin and pycnogenol have a therapeutic role in the treatment fo endothelial dysfunction.
Aug 01, 2003
Click here to read the entire abstract
Pubmed Data
: Int J Mol Med. 2003 Aug;12(2):269-73. PMID:
20421515
Article Published Date
: Aug 01, 2003
Study Type
: Animal Study
Additional Links
Substances
:
Flavonoids
,
Melatonin
Diseases
:
Endothelial Dysfunction
,
Hypertension
Pharmacological Actions
:
Antihypertensive Agents
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Melatonin causes regression and atrophy of the endometriotic lesions in rats.
Apr 01, 2008
Click here to read the entire abstract
Pubmed Data
: Fertil Steril. 2008 Apr;89(4):934-42. Epub 2007 Jun 19. PMID:
17582405
Article Published Date
: Apr 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Endometriosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
[+]
Morinda citrifolia leaf was more effective than the erlotinib in suppressing lung adenocarcinoma in mice.
Jan 13, 2016
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2016 Jan 14. Epub 2016 Jan 14. PMID:
26765787
Article Published Date
: Jan 13, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Noni
,
Noni leaf extract
Diseases
:
Carcinoma: Non-Small-Cell Lung
,
Lung Cancer
Pharmacological Actions
:
Antiproliferative
,
Cyclooxygenase 2 Inhibitors
,
Epidermal growth factor receptor (EGFR) inhibitor
,
Immunomodulatory
Additional Keywords
:
Dose Response
,
Superiority of Natural Substances versus Drugs
[+]
Mulberry fruit suppressed the development of intestinal inflammation and tumorgenesis both in vitro and in vivo.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2015 ;5:17348. Epub 2015 Nov 30. PMID:
26615818
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Mulberry
Diseases
:
Colitis
,
Colorectal Cancer: Prevention
,
Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
[+]
Myricetin has protective cardiovascular effects against ischemia/reperfusion-induced myocardial injury.
Aug 01, 2016
Click here to read the entire abstract
Pubmed Data
: Cardiovasc Toxicol. 2016 Aug 2. Epub 2016 Aug 2. PMID:
27484498
Article Published Date
: Aug 01, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Myricetin
Diseases
:
Myocardial Ischemia
Pharmacological Actions
:
Antioxidants
,
Cardioprotective
,
Cyclooxygenase 2 Inhibitors
,
Malondialdehyde Down-regulation
[+]
Nano-gold displayed anti-inflammatory properties.
Mar 18, 2018
Click here to read the entire abstract
Pubmed Data
: Artif Cells Nanomed Biotechnol. 2018 Mar 19:1-10. Epub 2018 Mar 19. PMID:
29553845
Article Published Date
: Mar 18, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Gold (nanoparticles)
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
[+]
Naringenin ameliorates learning and memory impairment following systemic lipopolysaccharide challenge.
Mar 04, 2018
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2018 Mar 5. Epub 2018 Mar 5. PMID:
29518393
Article Published Date
: Mar 04, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Naringenin
Diseases
:
Lipopolysaccharide-Induced Toxicity
,
Memory Disorders
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Neuroprotective Agents
,
NF-kappaB Inhibitor
,
Nrf2 activation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Anti-Inflammatory Agents
,
Lipopolysaccharide-Induced Toxicity
,
Memory Disorders
,
Naringenin
[+]
Naringenin suppresses the development of precancerous lesions via controlling hyperproliferation and inflammation in the colon.
Jan 17, 2018
Click here to read the entire abstract
Pubmed Data
: Environ Toxicol. 2018 Jan 18. Epub 2018 Jan 18. PMID:
29345053
Article Published Date
: Jan 17, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Naringenin
Diseases
:
Colon Cancer: Prevention
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
Additional Keywords
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Colon Cancer: Prevention
,
Naringenin
[+]
Nexrutine could be useful candidate agent for colon cancer chemoprevention and treatment.
Jul 31, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Carcinog. 2016 Aug ;55(8):1262-74. Epub 2015 Aug 10. PMID:
26259065
Article Published Date
: Jul 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Nexrutine (Phellodendrom)
Diseases
:
Colon Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
[+]
Nobiletin restored intestinal barrier function, which had been damaged after TNBS administration, through the inhibition of the Akt-NF-κB-MLCK pathway.
Apr 30, 2015
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2015 May ;59(5):829-42. Epub 2015 Mar 16. PMID:
25655748
Article Published Date
: Apr 30, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Citrus Peel
,
Nobiletin
Diseases
:
Colitis
,
Inflammation
,
Intestinal Permeability
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
[+]
Noni, and its major bioactive component damnacanthal, exhibits anti-inflammatory properties.
Nov 01, 2011
Click here to read the entire abstract
Pubmed Data
: Inflamm Allergy Drug Targets. 2011 Nov 1. Epub 2011 Nov 1. PMID:
21999179
Article Published Date
: Nov 01, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Damnacanthal
,
Noni
Diseases
:
Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Nitric Oxide Inhibitor
[+]
Nutmeg oil alleviates chronic inflammatory pain through inhibition of COX-2 expression.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Food Nutr Res. 2016 ;60:30849. Epub 2016 Apr 26. PMID:
27121041
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Nutmeg
Diseases
:
Allodynia
,
Chronic Pain
,
Inflammation
Pharmacological Actions
:
Analgesics
,
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Superiority of Natural Substances versus Drugs
Problem Substances
:
Diclofenac
[+]
Oligonol ameliorates carbon tetrachloride induced liver injury in rats.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2016 ;2016:3935841. Epub 2015 Dec 21. PMID:
26798422
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Lychee
Diseases
:
Chemically-Induced Liver Damage
,
Lipid Peroxidation
Pharmacological Actions
:
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Hepatoprotective
,
Interleukin-1 beta downregulation
,
Malondialdehyde Down-regulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Plant Extracts
[+]
Oligonol is effective in protecting against DSS-induced mouse colitis and colon carcinogenesis.
Jul 09, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Antioxid Redox Signal. 2013 Jul 10 ;19(2):102-14. Epub 2013 May 15. PMID:
23394584
Article Published Date
: Jul 09, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Lychee
Diseases
:
Colitis
,
Colon Cancer
,
Inflammation
,
Lipid Peroxidation
,
Oxidative Stress
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Colitis
,
COLON CANCER
,
Inflammation
,
Lipid Peroxidation
,
Lychee
,
oxidative stress
[+]
Olive leaf methanolic extract prevents ethanol-induced gastritis.
Jun 30, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Jul ;91:338-349. Epub 2017 May 2. PMID:
28463797
Article Published Date
: Jun 30, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Olive leaf extract
Diseases
:
Alcohol Toxicity
,
Gastritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Gastroprotective
,
Interleukin-1 beta downregulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Oral administration of black ginger extract significantly prevents UVB-induced photoaging in hairless mice.
Sep 30, 2014
Click here to read the entire abstract
Pubmed Data
: Photodermatol Photoimmunol Photomed. 2014 Oct ;30(5):237-45. Epub 2014 Jan 9. PMID:
24313661
Article Published Date
: Sep 30, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Kaempferia parviflora
Diseases
:
Aging Skin
,
Ultraviolet Radiation Induced Damage
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Catalase Up-Regulation
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Matrix Metalloproteinase-13 (MMP-13) Inhibitor
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-3 (MMP-3) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
NF-kappaB Inhibitor
,
Photoprotective
Additional Keywords
:
Plant Extracts
[+]
Oral cannabidiol has a beneficial action on two symptoms of established inflammation: edema and hyperalgesia.
Feb 29, 2004
Click here to read the entire abstract
Pubmed Data
: Naunyn Schmiedebergs Arch Pharmacol. 2004 Mar ;369(3):294-9. Epub 2004 Feb 12. PMID:
14963641
Article Published Date
: Feb 29, 2004
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
,
Cannabis
Diseases
:
Hyperalgesia
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Prostaglandin PGE2 downregulation
[+]
Oral curcumin may have chemopreventive properties against colorectal cancer.
Feb 01, 2001
Click here to read the entire abstract
Pubmed Data
: Cancer Res. 2001 Feb 1;61(3):1058-64. PMID:
11221833
Article Published Date
: Feb 01, 2001
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Cyclooxygenase 2 Inhibitors
[+]
Oral feeding of pomegranate fruit extract inhibits early biomarkers of UVB radiation-induced carcinogenesis.
Nov 01, 2010
Click here to read the entire abstract
Pubmed Data
: Photochem Photobiol. 2010 Nov-Dec;86(6):1318-26. Epub 2010 Oct 14. PMID:
20946358
Article Published Date
: Nov 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Pomegranate
Diseases
:
Lipid Peroxidation
,
Skin Cancer: Prevention
Therapeutic Actions
:
Sunlight exposure
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Plant Extracts
[+]
Oral tangeretin treatment effectively reduced the tumor cell proliferation markers and suppressed metastasis.
Oct 31, 2014
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2014 Nov ;25(11):1140-53. Epub 2014 Aug 1. PMID:
25151216
Article Published Date
: Oct 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Tangeretin
Diseases
:
Breast Cancer
,
Breast Cancer: Metastatic
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Apoptotic
,
Chemotherapeutic
,
Cyclooxygenase 2 Inhibitors
,
Nitric Oxide Inhibitor
[+]
Palmitoylethanolamide improves colon inflammation.
Jul 31, 2014
Click here to read the entire abstract
Pubmed Data
: Gut. 2014 Aug ;63(8):1300-12. Epub 2013 Sep 30. PMID:
24082036
Article Published Date
: Jul 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Palmitoylethanolamide
Diseases
:
Colitis
,
Ulcerative Colitis
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Palmitoylethanolamide protects mice against 6-OHDA-induced neurotoxicity and endoplasmic reticulum stress
Oct 31, 2016
Click here to read the entire abstract
Pubmed Data
: Pharmacol Res. 2016 Nov ;113(Pt A):276-289. Epub 2016 Sep 8. PMID:
27616549
Article Published Date
: Oct 31, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Palmitoylethanolamide
Diseases
:
Neurodegenerative Diseases
,
Oxidative Stress
,
Parkinson's Disease
Pharmacological Actions
:
Anti-Apoptotic
,
Cyclooxygenase 2 Inhibitors
,
Neuroprotective Agents
,
Nitric Oxide Inhibitor
,
Superoxide Dismutase Up-regulation
[+]
Panax ginseng anthocyanins pre-administration can significantly prevent cisplatin-induced nephrotoxicity.
Jul 20, 2017
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2017 Jul 21. Epub 2017 Jul 21. PMID:
28731262
Article Published Date
: Jul 20, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Anthocyanins
,
Panax Ginseng
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions
:
Chemoprotective Agents
,
Cyclooxygenase 2 Inhibitors
,
Nitric Oxide Inhibitor
Additional Keywords
:
Anthocyanins
,
Chemoprotective Agents
,
Chemotherapy-Induced Toxicity: Cisplatin
,
Cyclooxygenase 2 Inhibitors
,
Nitric Oxide Inhibitor
,
Panax Ginseng
[+]
Perilla frutescens and rosmarinic acid may play a role in ameliorating allergy diseases.
Jan 01, 2011
Click here to read the entire abstract
Pubmed Data
: Exp Biol Med (Maywood). 2011 Jan;236(1):99-106. PMID:
21239739
Article Published Date
: Jan 01, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Perilla
,
Rosmarinic acid
Diseases
:
Allergic Rhinitis
,
Allergic Rhinoconjunctivitis
Pharmacological Actions
:
Anti-Allergic Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
Additional Keywords
:
Plant Extracts
[+]
Phloretin inhibits phorbol ester-induced tumor promotion and expression of cyclooxygenase-2 in mouse skin.
Feb 29, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Med Food. 2012 Mar ;15(3):253-7. Epub 2011 Dec 19. PMID:
22181070
Article Published Date
: Feb 29, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Phloretin
Diseases
:
Skin Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
Additional Keywords
:
Anticarcinogenic Agents
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Phloretin
,
skin cancer
[+]
Pine need extract is anti-inflammatory and has a protective effect on cholesteorl oxidation.
Jan 01, 2008
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2008 Jan;46(1):175-85. Epub 2007 Jul 28. PMID:
17804140
Article Published Date
: Jan 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Flavonoids
,
Pine Needle
,
Polyphenols
Diseases
:
Cholesterol: Oxidation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Enzyme Inhibitors
[+]
Plant-derived oil rich in ALA could ameliorate the inflammatory damage in colitis.
Aug 13, 2015
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2015 Aug 14. Epub 2015 Aug 14. PMID:
26350254
Article Published Date
: Aug 13, 2015
Study Type
: Animal Study
Additional Links
Substances
:
ALA (Alpha-Linolenic Acid)
Diseases
:
Colitis
,
Inflammatory Bowel Diseases
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Pomegranate by-products could be used in colorectal cancer chemoprevention.
Sep 24, 2017
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2017 Sep 25. Epub 2017 Sep 25. PMID:
28948694
Article Published Date
: Sep 24, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Pomegranate
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Apoptotic
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
[+]
Pomegranate extract is abundant in hydrolysable tannins that display multiple anti-acne capacities.
Jan 11, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2017 Jan 12 ;18(1). Epub 2017 Jan 12. PMID:
28085116
Article Published Date
: Jan 11, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Pomegranate
Diseases
:
Acne
Pharmacological Actions
:
Anti-Bacterial Agents
,
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Prostaglandin PGE2 downregulation
Additional Keywords
:
Plant Extracts
[+]
Punicalagin inhibits lipopolysaccharide induced memory impairment via anti-inflammatory and anti-amylogenic mechanisms.
Jan 25, 2017
Click here to read the entire abstract
Pubmed Data
: Neuropharmacology. 2017 Jan 26 ;117:21-32. Epub 2017 Jan 26. PMID:
28132781
Article Published Date
: Jan 25, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Punicalagin
Diseases
:
Brain Inflammation
,
Lipopolysaccharide-Induced Toxicity
,
Memory Disorders
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Punicalagin protected rat livers against cyclophosphamide toxicity.
Jun 30, 2016
Click here to read the entire abstract
Pubmed Data
: Environ Toxicol Pharmacol. 2016 Jul ;45:158-62. Epub 2016 Aug 1. PMID:
27310207
Article Published Date
: Jun 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Punicalagin
Diseases
:
Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Hepatoprotective
[+]
Purple sweet potato induces antioxidant defense via the Nrf2 pathway and reduces inflammation via NF-κB inhibition in DMN-induced liver injury.
Dec 31, 2010
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2011 Jan ;49(1):93-9. Epub 2010 Oct 8. PMID:
20934476
Article Published Date
: Dec 31, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Anthocyanins
,
Sweet Potato: Purple
Diseases
:
Chemically-Induced Liver Damage
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Hepatoprotective
,
NF-kappaB Inhibitor
,
Nrf2 activation
[+]
Purple sweet potato may be useful for mitigating inflammatory brain diseases by the inhibition of proinflammatory molecule production.
Jan 31, 2010
Click here to read the entire abstract
Pubmed Data
: Neurochem Int. 2010 Feb ;56(3):424-30. Epub 2009 Nov 24. PMID:
19941923
Article Published Date
: Jan 31, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Sweet Potato: Purple
Diseases
:
Brain Inflammation
,
Lipopolysaccharide-Induced Toxicity
,
Memory Disorders
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Neuroprotective Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Quercetin application attenuated mucosal damage from ischemia reperfusion injury by inhibiting neutrophil infiltration.
Aug 27, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Aug 28 ;95:346-354. Epub 2017 Aug 28. PMID:
28858733
Article Published Date
: Aug 27, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Quercetin
Diseases
:
Intestinal Ischemia
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Gastroprotective
[+]
Quercetin can efficiently prevent stress induced neurological complications by rescuing brain from oxidative and inflammatory stress.
Mar 14, 2017
Click here to read the entire abstract
Pubmed Data
: Physiol Behav. 2017 Mar 15 ;171:69-78. Epub 2017 Jan 7. PMID:
28069457
Article Published Date
: Mar 14, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Nettle
,
Quercetin
Diseases
:
Brain: Oxidative Stress
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Anti-Inflammatory Agents
,
Antioxidants
,
Brain: Oxidative Stress
,
nettle
,
oxidative stress
,
QUERCETIN
[+]
Quercitrin attenuates acetaminophen induced liver damage by the activation of defensive genes and the inhibition of pro-inflammatory genes.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2016 ;8(7). Epub 2016 Jul 15. PMID:
27428996
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Toona sinensis
Diseases
:
Acetaminophen (Tylenol) Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
NF-E2-Related Factor-2 (Nrf2) Modulator
Problem Substances
:
Acetaminophen
,
Paracetamol
[+]
Red light modulates ultraviolet-induced gene expression in the epidermis of hairless mice.
Sep 30, 2015
Click here to read the entire abstract
Pubmed Data
: Photomed Laser Surg. 2015 Oct ;33(10):498-503. Epub 2015 Sep 23. PMID:
26398729
Article Published Date
: Sep 30, 2015
Study Type
: Animal Study
Additional Links
Diseases
:
Ultraviolet Radiation Induced Damage
Therapeutic Actions
:
Light-Emitting Diodes (LEDs) Therapy
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Gene Expression Regulation
[+]
Red wine and black tea and polyphenolic extracts modulate COX-2, iNOS and GSH-related gene expression in tumors, suggesting also a possible chemotherapeutic activity of these compounds.
May 31, 2002
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Nutr. 2002 Jun ;132(6):1376-9. PMID:
12042461
Article Published Date
: May 31, 2002
Study Type
: Animal Study
Additional Links
Substances
:
Black Tea
,
Polyphenols
,
Red Wine
Diseases
:
Colon Cancer
,
Colon Cancer: Prevention
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemotherapeutic
,
Cyclooxygenase 2 Inhibitors
,
Cyclooxygenase Inhibitors
,
Enzyme Inhibitors
,
Nitric Oxide Inhibitor
Additional Keywords
:
Gene Expression Regulation
[+]
Resveratrol has anti-inflammatory and chemopreventive properties in an animal model of liver cancer.
Jun 01, 2010
Click here to read the entire abstract
Pubmed Data
: Pharm Res. 2010 Jun;27(6):1080-91. Epub 2010 Apr 20. PMID:
20405173
Article Published Date
: Jun 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Resveratrol
Diseases
:
Inflammation
,
Liver Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Cyclooxygenase 2 Inhibitors
,
Heat Shock Protein Inducer
,
NF-kappaB Inhibitor
Additional Keywords
:
Stilbenes
[+]
Resveratrol has anti-inflammatory and neuroprotective properties in experimental diabetic neuropathy.
Apr 02, 2010
Click here to read the entire abstract
Pubmed Data
: Biochem Biophys Res Commun. 2010 Apr 2;394(2):360-5. Epub 2010 Mar 6. PMID:
20211601
Article Published Date
: Apr 02, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Resveratrol
,
Stilbenes
Diseases
:
Diabetic Neuropathy
,
Oxidative Stress
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
Malondialdehyde Down-regulation
,
Neuroprotective Agents
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Resveratrol inhibits proinflammatory cytokine (IL-8) production in monocytic cells.
Jan 01, 2009
Click here to read the entire abstract
Pubmed Data
: Am J Chin Med. 2009;37(6):1203-14. PMID:
19938227
Article Published Date
: Jan 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Resveratrol
Diseases
:
Inflammation
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Immunomodulatory
,
Interleukin-8 downregulation
,
NF-kappaB Inhibitor
[+]
Resveratrol may protect against colitis through up-regulation of SIRT1 in immune cells in the colon.
Mar 01, 2010
Click here to read the entire abstract
Pubmed Data
: J Pharmacol Exp Ther. 2010 Mar;332(3):829-39. Epub 2009 Nov 25. PMID:
19940103
Article Published Date
: Mar 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Resveratrol
,
Stilbenes
Diseases
:
Colitis
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
SIRT1 Activator
[+]
Rosmarinic acid has an ameliorative effect on colonic inflammation and thus a potential therapeutic role in colitis.
Apr 05, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2017 Apr 6 ;7:46252. Epub 2017 Apr 6. PMID:
28383063
Article Published Date
: Apr 05, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Rosmarinic acid
Diseases
:
Ulcerative Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-22 Downregulation
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
,
STAT3 Inhibitor
[+]
Rosmarinic acid mitigates lipopolysaccharide-induced neuroinflammatory responses.
Jan 08, 2018
Click here to read the entire abstract
Pubmed Data
: Inflammation. 2018 Jan 9. Epub 2018 Jan 9. PMID:
29318480
Article Published Date
: Jan 08, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Rosmarinic acid
Diseases
:
Brain Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Neuroprotective Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Royal jelly showed anti-inflammatory and antioxidant properties in experimental colitis
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: ScientificWorldJournal. 2015 ;2015:956235. Epub 2015 Mar 2. PMID:
25821860
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Royal Jelly
Diseases
:
Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
[+]
Ruta graveolens extract had anti-inflammatory and antioxidant activity, with potent inhibitory effects on the arachidonic acid pathways.
Feb 28, 2014
Click here to read the entire abstract
Pubmed Data
: Chin J Nat Med. 2014 Mar ;12(3):172-9. PMID:
24702802
Article Published Date
: Feb 28, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Ruta Graveolens
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 1 Inhibitor
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Phytotherapy
,
Plant Extracts
[+]
Rutin ameliorated the schemia-reperfusion induced ovarian injury.
Mar 21, 2018
Click here to read the entire abstract
Pubmed Data
: Gynecol Endocrinol. 2018 Mar 22:1-6. Epub 2018 Mar 22. PMID:
29564969
Article Published Date
: Mar 21, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Rutin
Diseases
:
Ischemia
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Rutin exhibits significant physiological, biochemical and immunological protection against Methotrexate induced intestinal toxicity.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Complement Altern Med. 2016 ;16:99. Epub 2016 Mar 10. PMID:
26965456
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Rutin
Diseases
:
Drug-Induced Toxicity: Methotrexate
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 1 Inhibitor
,
Cyclooxygenase 2 Inhibitors
[+]
Salvianolic acid B inhibits high-fat diet-induced inflammation by activating the Nrf2 pathway.
Jul 31, 2017
Click here to read the entire abstract
Pubmed Data
: J Food Sci. 2017 Aug ;82(8):1953-1960. Epub 2017 Jul 28. PMID:
28753232
Article Published Date
: Jul 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Red Sage
Diseases
:
High Fat Diet
,
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Interleukin-10 downregulation
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
,
Nrf2 activation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Plant Extracts
[+]
Saturated fatty acids, palm oil and medium chain triglycerides, reverse inflammatory and fibrotic changes in rat liver despite continued ethanol administration.
Nov 01, 2001
Click here to read the entire abstract
Pubmed Data
: J Pharmacol Exp Ther. 2001 Nov;299(2):638-44. PMID:
11602676
Article Published Date
: Nov 01, 2001
Study Type
: Animal Study
Additional Links
Substances
:
Medium Chain Triglycerides
,
Palm Oil
,
Saturated fatty acids
Diseases
:
Alcoholic Liver Disease
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Beneficial Saturated Fats
[+]
Sea buckthorn can be used as a therapeutic agent in inflammatory diseases.
Apr 12, 2017
Click here to read the entire abstract
Pubmed Data
: Inflammopharmacology. 2017 Apr 13. Epub 2017 Apr 13. PMID:
28409391
Article Published Date
: Apr 12, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Sea buckthorn
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interferon Gamma Reducer
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Sesamol suppresses cyclooxygenase-2 transcriptional activity in colon cancer cells.
Feb 28, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Clin Biochem Nutr. 2014 Mar ;54(2):95-101. Epub 2014 Feb 19. PMID:
24688218
Article Published Date
: Feb 28, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Sesamol
Diseases
:
Colon Cancer
Pharmacological Actions
:
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
Prostaglandin PGE2 downregulation
[+]
Silibinin inhibits lung tumor angiogenesis in an animal model.
Jun 20, 2006
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Natl Cancer Inst. 2006 Jun 21 ;98(12):846-55. PMID:
16788158
Article Published Date
: Jun 20, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Silibinin
Diseases
:
Inflammation
,
Lung Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
,
Cyclooxygenase 2 Inhibitors
,
Vascular Endothelial Growth Factor Inhibitors
[+]
Sour cherry juice has antioxidant and anti-inflammatory activity.
Dec 01, 2009
Click here to read the entire abstract
Pubmed Data
: Plant Foods Hum Nutr. 2009 Dec;64(4):231-7. PMID:
19763832
Article Published Date
: Dec 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Sour Cherry
Diseases
:
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Plant Extracts
[+]
Sulforaphane exhibits chemopreventive properties against intestinal polyps in mice.
Dec 01, 2006
Click here to read the entire abstract
Pubmed Data
: Biopharm Drug Dispos. 2006 Dec;27(9):407-20. PMID:
16952200
Article Published Date
: Dec 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Adenomatous Polyposis Coli
,
Intestinal Polyps
Pharmacological Actions
:
Anticarcinogenic Agents
,
Cyclooxygenase 2 Inhibitors
[+]
Sulforaphane may be a potential a candidate for use in the treatment of acute lung injury.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: Int J Mol Med. 2016 Jan ;37(1):182-8. Epub 2015 Oct 27. PMID:
26531002
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
NF-E2-Related Factor-2 (Nrf2) Modulator
,
Prostaglandin PGE2 downregulation
[+]
Supplementation with probiotics was able to reduce tumor incidence, tumor multiplicity and average tumor size.
Apr 30, 2015
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2015 May-Jun;67(4):603-11. Epub 2015 Mar 26. PMID:
25811420
Article Published Date
: Apr 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Lactobacillus rhamnosus
,
Probiotics
Diseases
:
Colon Cancer
,
Colon Cancer: Prevention
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Supplementation
[+]
Taheebo polyphenols attenuate free fatty acid-induced inflammation.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Nutr. 2017 ;4:63. Epub 2017 Dec 12. PMID:
29312947
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Pau D'Arco
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
[+]
The concomitant reduction in COX-2 expression in paw tissues suggested kaempferol's role in mitigation of inflammation by targeting STAT3 and NF-κB.
Nov 30, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biochem Biophys Rep. 2017 Dec ;12:54-61. Epub 2017 Aug 26. PMID:
28955792
Article Published Date
: Nov 30, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Kaempferol
Diseases
:
Inflammation
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
,
STAT3 Inhibitor
[+]
The ethanolic extract of Justicia gendarussa showed significant anti-arthritic activity that was statistically similar to that of aspirin.
Dec 31, 2008
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Clinics (Sao Paulo). 2009 ;64(4):357-62. PMID:
19488595
Article Published Date
: Dec 31, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Justicia gendarussa
Diseases
:
Arthritis
Pharmacological Actions
:
5-Lipoxygenase Inhibitor
,
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Natural Substances Versus Drugs
,
Plant Extracts
[+]
The flower extract of Rosa rugosa may be a beneficial anti-inflammatory agent.
Feb 29, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomol Ther (Seoul). 2016 Mar 1 ;24(2):184-90. PMID:
26797110
Article Published Date
: Feb 29, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Rose
Diseases
:
Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
,
Nitric Oxide Inhibitor
,
Prostaglandin PGE2 downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Plant Extracts
[+]
The present data suggest that apocynin possesses a potential anti-hepatocarcinogenic property.
May 31, 2017
Click here to read the entire abstract
Pubmed Data
: Toxicol Pathol. 2017 Jun ;45(4):544-550. Epub 2017 Jun 2. PMID:
28573935
Article Published Date
: May 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Apocynin
Diseases
:
Liver Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
[+]
The present investigation provides pharmacological evidence to support the folklore claim that J. gendarussa is an anti-inflammatory agent.
Jun 30, 2011
Click here to read the entire abstract
Pubmed Data
: J Nat Med. 2011 Jul ;65(3-4):471-9. Epub 2011 Mar 17. PMID:
21416126
Article Published Date
: Jun 30, 2011
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Justicia gendarussa
Diseases
:
Inflammation
Pharmacological Actions
:
15-Lipoxygenase (15-LOX) Inhibitor
,
5-Lipoxygenase Inhibitor
,
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
Prostaglandin PGE2 downregulation
Additional Keywords
:
Folk Medicine
,
Plant Extracts
[+]
The present study concluded that Spirulina is able to restrain the changes produced through adjuvant-induced arthritis.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(4):e0121523. Epub 2015 Apr 8. PMID:
25853428
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Spirulina
Diseases
:
Arthritis
Pharmacological Actions
:
Anti-Angiogenic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
[+]
These findings confirm the chemopreventive potential of chrysin against benzo(a)pyrene induced lung cancer in Swiss albino mice.
Mar 31, 2016
Click here to read the entire abstract
Pubmed Data
: Pharmacol Rep. 2016 Apr ;68(2):310-8. Epub 2015 Sep 6. PMID:
26922533
Article Published Date
: Mar 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Chrysin
Diseases
:
Lung Cancer
,
Lung Cancer: Prevention
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
Problem Substances
:
Benzo(a)pyrene
[+]
These findings confirmed the anti-inflammatory effects of resveratrol and quercetin in BLM-induced lung damage.
Aug 31, 2015
Click here to read the entire abstract
Pubmed Data
: Br J Nutr. 2015 Sep ;114(6):853-865. PMID:
26334388
Article Published Date
: Aug 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Mangiferin
,
Quercetin
,
Resveratrol
Diseases
:
Pulmonary Fibrosis
,
Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
[+]
These findings demonstrate that beta-caryophylleneprovides neuroprotection against rotenone-induced Parkinson disease.
Jun 30, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Cell Biochem. 2016 Jul ;418(1-2):59-70. Epub 2016 Jun 17. PMID:
27316720
Article Published Date
: Jun 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Beta-Caryophyllene
Diseases
:
Brain Inflammation
,
Oxidative Stress
,
Parkinson's Disease
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Neuroprotective Agents
[+]
These findings strongly suggest that the anti-inflammatory actions of Thymoquinone are caused by suppression of IRAK-linked AP-1/NF-κB pathways.
Feb 19, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2017 Feb 20 ;7:42995. Epub 2017 Feb 20. PMID:
28216638
Article Published Date
: Feb 19, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Thymoquinone
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
,
Nitric Oxide Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Inflammation
,
Interleukin-1 beta downregulation
,
thymoquinone
[+]
These findings suggest that shikonin has therapeutic potential for osteoarthritis.
Sep 30, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2016 Oct ;12(4):2735-2740. Epub 2016 Aug 31. PMID:
27703516
Article Published Date
: Sep 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Shikonin
Diseases
:
Osteoarthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
These results indicate that shikonin treatment may prevent the loss of vision associated with diabetic retinopathy.
Mar 20, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2017 Mar 21 ;7:44985. Epub 2017 Mar 21. PMID:
28322323
Article Published Date
: Mar 20, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Shikonin
Diseases
:
Diabetic Retinopathy
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Diabetic Retinopathy
,
Shikonin
[+]
These results indicate the potential antidiabetic benefits of M. oleifera ethanolic leaf extract.
May 02, 2017
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2017 May 3. Epub 2017 May 3. PMID:
28467233
Article Published Date
: May 02, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Moringa oleifera
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Hypoglycemic Agents
,
Hypolipidemic
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Renoprotective
Additional Keywords
:
Plant Extracts
[+]
These results indicate the potential of compounds from Quercus gilva Bume in the treatment of urolithiasis.
Jul 04, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2017 Jul 5 ;22(7). Epub 2017 Jul 5. PMID:
28678204
Article Published Date
: Jul 04, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Oak
Diseases
:
Urolithiasis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antiurolithiatic
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
Additional Keywords
:
Dose Response
[+]
These results provide powerful evidence for the chemopreventive efficacy of Chrysin against chemically induced renal carcinogenesis.
Jul 08, 2016
Click here to read the entire abstract
Pubmed Data
: Arch Biochem Biophys. 2016 Jul 9. Epub 2016 Jul 9. PMID:
27403965
Article Published Date
: Jul 08, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Chrysin
Diseases
:
Kidney Cancer
,
Kidney Cancer: Prevention
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Antioxidants
,
Apoptotic
,
Bcl-2 protein down-regulation
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
These results provide scientific evidence for the use of E. longifolia as a potential analgesic and anti-inflammatory agent.
Feb 29, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Arch Pharm Res. 2016 Mar ;39(3):421-8. Epub 2016 Jan 30. PMID:
26832325
Article Published Date
: Feb 29, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Tongkat Ali
Diseases
:
Inflammation
Pharmacological Actions
:
Analgesics
,
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
Additional Keywords
:
Dose Response
,
Superiority of Natural Substances versus Drugs
Problem Substances
:
Diclofenac
[+]
These results suggest that the anti-inflammatory effect of delphinidin alleviated inflammation in a spinal cord injury model.
Nov 30, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2017 Dec ;14(6):5583-5588. Epub 2017 Sep 27. PMID:
29285096
Article Published Date
: Nov 30, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Delphinidin
Diseases
:
Spinal Cord Injuries
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Postaglandin PGE2 downregulation
[+]
This study demonstrated the anti-arthritic, anti-inflammatory, anti-oxidative stress and chondro-protective potentials of sesamol in vivo.
Sep 30, 2013
Click here to read the entire abstract
Pubmed Data
: Eur J Nutr. 2013 Oct ;52(7):1787-99. Epub 2012 Dec 27. PMID:
23269651
Article Published Date
: Sep 30, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Sesamol
Diseases
:
Arthritis
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Chondroprotective
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
This study indicates that a methanol extract from Inonotus obliquus has anti-inflammatory and anti-nociceptive properties.
Oct 02, 2005
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2005 Oct 3 ;101(1-3):120-8. PMID:
15905055
Article Published Date
: Oct 02, 2005
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Chaga Mushroom (Inonotus obliquus)
Diseases
:
Inflammation
Pharmacological Actions
:
Analgesics
,
Anti-Inflammatory Agents
,
Antinoceceptive
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Nitric Oxide Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Thymol mitigates lipopolysaccharide-induced endometritis.
Mar 20, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2017 Mar 21 ;8(12):20042-20055. PMID:
28223539
Article Published Date
: Mar 20, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Thymol
Diseases
:
Endometritis
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Thymoquinone abolishes a number of factors known to be involved in rheumatoid arthritis pathogenesis.
Dec 31, 2010
Click here to read the entire abstract
Pubmed Data
: J Cell Biochem. 2011 Jan ;112(1):107-17. PMID:
20872780
Article Published Date
: Dec 31, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Thymoquinone
Diseases
:
Inflammation
,
Rheumatoid Arthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antiproliferative
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Anti-Inflammatory Agents
,
Antiproliferative
,
Inflammation
,
rheumatoid arthritis
,
thymoquinone
[+]
Thymoquinone augmented the chemopreventive effect of vitamin D during the initiation phase of colon cancer.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Am J Transl Res. 2017 ;9(2):774-790. Epub 2017 Feb 15. PMID:
28337306
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Thymoquinone
,
Vitamin D
Diseases
:
Colon Cancer
Pharmacological Actions
:
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
Additional Keywords
:
Natural Substance Synergy
[+]
Thymoquinone could confer intestinal protection against methotrexate induced mucositis.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Pharmacogn Mag. 2016 Jan ;12(Suppl 1):S76-81. PMID:
27041864
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Thymoquinone
Diseases
:
Drug Toxicity: Methotrexate
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Apoptotic
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
[+]
Thymoquinone inhibits LoVo cancer cell growth and migration.
Feb 20, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: World J Gastroenterol. 2017 Feb 21 ;23(7):1171-1179. PMID:
28275297
Article Published Date
: Feb 20, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Thymoquinone
Diseases
:
Colon Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anti-metastatic
,
Antiproliferative
,
Cyclooxygenase 2 Inhibitors
,
Prostaglandin PGE2 downregulation
Additional Keywords
:
Dose Response
[+]
Tormentic acid may be a potential therapeutic candidate for the prevention of acetaminophen induced liver injury.
May 17, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2017 May 18 ;22(5). Epub 2017 May 18. PMID:
28524081
Article Published Date
: May 17, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Loquat
Diseases
:
Acetaminophen (Tylenol) Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Hepatoprotective
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances
:
Acetaminophen
,
Paracetamol
[+]
Treatment with taraxasterol significantly increased the pain thresholds and reduced the clinical arthritic scores of mice.
Nov 30, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2016 Dec ;12(6):4035-4040. Epub 2016 Nov 2. PMID:
28101182
Article Published Date
: Nov 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Dandelion
Diseases
:
Rheumatoid Arthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Nitric Oxide Inhibitor
,
Prostaglandin PGE2 downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Ultralow doses of cannabinoid drugs protect the mouse brain from inflammation-induced cognitive damage.
Nov 30, 2014
Click here to read the entire abstract
Pubmed Data
: J Neurosci Res. 2014 Dec ;92(12):1669-77. Epub 2014 Jul 16. PMID:
25042014
Article Published Date
: Nov 30, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Delta-tetrahydrocannabinol (THC)
Diseases
:
Brain Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Neuroprotective Agents
[+]
Vitamin C has protective effects against spinal cord injury-induced kidney damage.
Mar 31, 2015
Click here to read the entire abstract
Pubmed Data
: Neurol Sci. 2015 Apr ;36(4):521-6. Epub 2014 Nov 18. PMID:
25403314
Article Published Date
: Mar 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Spinal Cord Injuries
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Vitamin D3 and 5-FU synergise together and exhibit better anticancer effects by modulating Wnt/β-catenin pathway.
Jul 24, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Exp Clin Cancer Res. 2015 Jul 25 ;34:71. Epub 2015 Jul 25. PMID:
26205949
Article Published Date
: Jul 24, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin D
Diseases
:
Colon Cancer
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Heat Shock Protein Down-Regulation
,
Wnt/β-catenin signaling pathway modulation
Additional Keywords
:
Chemothapeutic Synergy: 5-flourouracil
[+]
Walnut leaf extract exert protective effects against diabetic retinopathy.
Oct 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Iran J Basic Med Sci. 2017 Nov ;20(11):1275-1281. PMID:
29299206
Article Published Date
: Oct 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Walnut
Diseases
:
Diabetic Retinopathy
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Diabetic Retinopathy
,
Walnut
[+]
Walnuts reduced prostate tumor growth by affecting energy metabolism along with decreased plasma IGF-1 and cholesterol.
Nov 30, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Med Food. 2014 Dec ;17(12):1281-6. PMID:
25354213
Article Published Date
: Nov 30, 2014
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Walnut
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Antiproliferative
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Dietary Concentrations
[+]
Wogonin and 5-fluorouracil combination treatment caused a significant growth inhibition of human tumor xenografts in vivo.
Jul 31, 2013
Click here to read the entire abstract
Pubmed Data
: Biochem Cell Biol. 2013 Aug ;91(4):221-9. Epub 2013 Feb 14. PMID:
23859016
Article Published Date
: Jul 31, 2013
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Wogonin
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Chemosensitizer
,
Cyclooxygenase 2 Inhibitors
,
Cyclooxygenase Inhibitors
Additional Keywords
:
Drug: 5-flourouracil
,
Natural Substance/Drug Synergy
,
Plant Extracts
[+]
Wogonin prevents alcohol-induced gastric mucosal damage in rats.
Aug 01, 2008
Click here to read the entire abstract
Pubmed Data
: Appl Environ Microbiol. 2008 Aug;74(15):4650-5. Epub 2008 Jun 6. PMID:
15139485
Article Published Date
: Aug 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Wogonin
Diseases
:
Alcohol Toxicity
Pharmacological Actions
:
Apoptotic
,
Cyclooxygenase 2 Inhibitors
[+]
Zerumbone possesses anti-inflammatory and antinociceptive effects.
Feb 17, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2016 Feb 18 ;17(2):249. Epub 2016 Feb 18. PMID:
26901193
Article Published Date
: Feb 17, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Zerumbone
Diseases
:
Arthritis
,
Lipopolysaccharide-Induced Toxicity
,
Osteoarthritis
Pharmacological Actions
:
Analgesics
,
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Matrix Metalloproteinase-13 (MMP-13) Inhibitor
[+]
Zerumbone reduced the inflammatory response of acute lung injury in endotoxin-treated mice.
Apr 21, 2017
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2017 Apr 22 ;271:9-14. Epub 2017 Apr 22. PMID:
28442377
Article Published Date
: Apr 21, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Zerumbone
Diseases
:
Lipopolysaccharide-Induced Toxicity
,
Lung Injury: Acute
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
α-solanine may be a promising therapeutic against inflammatory diseases by inhibiting the NF-κB signaling pathway.
Mar 01, 2016
Click here to read the entire abstract
Pubmed Data
: J Cell Biochem. 2016 Mar 2. Epub 2016 Mar 2. PMID:
26931732
Article Published Date
: Mar 01, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Potato
Diseases
:
Inflammation
,
Lipopolysaccharide-Induced Toxicity
,
Sepsis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
β-patchoulene isolated from patchouli oil had Anti-inflammatory activity.
Apr 13, 2016
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2016 Apr 14. Epub 2016 Apr 14. PMID:
27090925
Article Published Date
: Apr 13, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Patchouli
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Malondialdehyde Down-regulation
,
Nitric Oxide Inhibitor
,
Prostaglandin PGE2 downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Dose Response
,
Plant Oils
[+]
ω-3 polyunsaturated fatty acids had inhibitory effects on endometrial cancer development.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2015;5:14958. Epub 2015 Oct 15. PMID:
26468779
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Polyunsaturated Fatty Acids (PUFAs)
Diseases
:
Endometrial Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
Prostaglandin PGE2 downregulation
Additional Keywords
:
Risk Reduction
[+]
"Anti-inflammatory effects of fucoidan through inhibition of NF-κB, MAPK and Akt activation in lipopolysaccharide-induced BV2 microglia cells."
Jul 31, 2011
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2011 Aug ;49(8):1745-52. Epub 2011 May 4. PMID:
21570441
Article Published Date
: Jul 31, 2011
Study Type
: In Vitro Study
Additional Links
Substances
:
Fucoidan
Diseases
:
Brain: Microglial Activation
,
Brain Inflammation
,
Lipopolysaccharide-Induced Toxicity
,
Neurodegenerative Diseases
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Plant Extracts
[+]
"Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells."
Jul 31, 2012
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2012 Aug ;53(1):77-90. Epub 2012 Feb 16. PMID:
22335196
Article Published Date
: Jul 31, 2012
Study Type
: In Vitro Study
Additional Links
Substances
:
Melatonin
Diseases
:
Breast Cancer
Pharmacological Actions
:
Antioxidants
,
Antiproliferative
,
Apaf-1/caspase-dependent apoptotic pathway activator
,
Apoptotic
,
Cyclooxygenase 2 Inhibitors
,
p300/NF-κB down-regulation
,
PI3K/Akt/signaling suppression
[+]
18β-Glycyrrhetinic acid may be used as a chemopreventive agent in liver cancer.
Apr 25, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Cell Biochem. 2016 Apr 26. Epub 2016 Apr 26. PMID:
27116616
Article Published Date
: Apr 25, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
18β-Glycyrrhetinic Acid
Diseases
:
Liver Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antiproliferative
,
Apoptotic
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
A comparative study on hulled adlay and unhulled adlay through evaluation of their LPS-induced anti-inflammatory effects.
Feb 28, 2015
Click here to read the entire abstract
Pubmed Data
: Chem Biodivers. 2015 Mar ;12(3):380-7. PMID:
25766911
Article Published Date
: Feb 28, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Adlay
Diseases
:
Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Nitric Oxide Inhibitor
Additional Keywords
:
Plant Extracts
[+]
A guava leaf extract contains potential therapeutic agents, which regulate NF-κB activation, for the treatment of inflammatory conditions.
Oct 31, 2015
Click here to read the entire abstract
Pubmed Data
: Fish Shellfish Immunol. 2015 Nov ;47(1):85-92. Epub 2015 Aug 29. PMID:
26327113
Article Published Date
: Oct 31, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Flavonoids
,
Guava
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-10 downregulation
,
Interleukin-1 beta downregulation
,
Postaglandin PGE2 downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Dose Response
,
Plant Extracts
[+]
A hexane fraction of P. vulgaris var. lilacina may be a potent anti-inflammatory candidate.
Dec 31, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2013 ;14(11):21489-503. Epub 2013 Oct 30. PMID:
24177568
Article Published Date
: Dec 31, 2012
Study Type
: In Vitro Study
Additional Links
Substances
:
Prunella vulgaris
Diseases
:
Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Prostaglandin PGE2 downregulation
Additional Keywords
:
Plant Extracts
[+]
A polar extract of Curcuma longa protects cartilage homeostasis
Jan 07, 2018
Click here to read the entire abstract
Pubmed Data
: Inflammopharmacology. 2018 Jan 8. Epub 2018 Jan 8. PMID:
29313174
Article Published Date
: Jan 07, 2018
Study Type
: In Vitro Study
Additional Links
Substances
:
Turmeric
Diseases
:
Osteoarthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
Interleukin-8 downregulation
,
Postaglandin PGE2 downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
A wogonin-rich-fraction of Scutellaria baicalensis root extract exerts chondroprotective effects.
Mar 02, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2017 Mar 3 ;7:43789. Epub 2017 Mar 3. PMID:
28256567
Article Published Date
: Mar 02, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Wogonin
Diseases
:
Osteoarthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Chondroprotective
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Matrix Metalloproteinase-13 (MMP-13) Inhibitor
,
Matrix metalloproteinase-3 (MMP-3) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Achillea fragrantissima possesses anti-neuroinflammatory activities for prevention or treatment of neurodegenerative diseases.
Dec 31, 2010
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Complement Altern Med. 2011 ;11:98. Epub 2011 Oct 21. PMID:
22018032
Article Published Date
: Dec 31, 2010
Study Type
: In Vitro Study
Additional Links
Substances
:
Achillea fragrantissima
Diseases
:
Brain: Microglial Activation
,
Brain Inflammation
,
Neurodegenerative Diseases
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Neuroprotective Agents
,
Nitric Oxide Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Plant Extracts
[+]
American Ginseng inhibits induced COX-2 and NFKB activation in breast cancer cells.
Dec 01, 2009
Click here to read the entire abstract
Pubmed Data
: J Surg Res. 2009 Dec;157(2):261-7. Epub 2009 Jun 6. PMID:
19815237
Article Published Date
: Dec 01, 2009
Study Type
: In Vitro Study
Additional Links
Substances
:
Ginseng (American)
Diseases
:
Breast Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
Additional Keywords
:
Plant Extracts
[+]
An extract of Lotus may be a powerful agent against colon cancer cells.
Feb 28, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncol Lett. 2017 Mar ;13(3):1470-1478. Epub 2016 Dec 28. PMID:
28454279
Article Published Date
: Feb 28, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Lotus
Diseases
:
Colon Cancer
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
,
Bcl-xL down-regulation
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
NF-kappaB Inhibitor
Additional Keywords
:
Apoptotic
,
Bcl-2 protein down-regulation
,
COLON CANCER
,
Lotus
,
Plant Extracts
[+]
Anti-inflammatory activity of ethanol extract derived from Phaseolus angularis beans.
Oct 10, 2011
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2011 Oct 11 ;137(3):1197-206. Epub 2011 Aug 2. PMID:
21821108
Article Published Date
: Oct 10, 2011
Study Type
: In Vitro Study
Additional Links
Substances
:
Aduki bean
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Plant Extracts
[+]
Anti-inflammatory effects of trilinolein from Panax notoginseng.
Dec 31, 2013
Click here to read the entire abstract
Pubmed Data
: Am J Chin Med. 2014 ;42(6):1485-506. PMID:
25482678
Article Published Date
: Dec 31, 2013
Study Type
: In Vitro Study
Additional Links
Substances
:
Panax Notoginseng
Diseases
:
Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Malondialdehyde Down-regulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Phytotherapy
[+]
Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis.
Feb 14, 2013
Click here to read the entire abstract
Pubmed Data
: Phytomedicine. 2013 Feb 15 ;20(3-4):328-36. Epub 2012 Dec 6. PMID:
23219337
Article Published Date
: Feb 14, 2013
Study Type
: In Vitro Study
Additional Links
Substances
:
Chinese Skullcap
,
Wogonin
Diseases
:
Osteosarcoma
Pharmacological Actions
:
Anti-metastatic
,
Cyclooxygenase 2 Inhibitors
,
VEGFR3 inhibition
Additional Keywords
:
Phytotherapy
[+]
Antioxidants have been shown to significantly influence cell growth, DNA repair and mitochondrial membrane-mediated apoptosis.
Dec 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2014 ;15(9):16226-45. Epub 2014 Sep 15. PMID:
25226533
Article Published Date
: Dec 31, 2013
Study Type
: Review
Additional Links
Substances
:
Flavonoids
,
Ginsenosides
,
Polyphenols
,
Ursolic Acid
Diseases
:
Cancers: All
,
DNA damage
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anti-metastatic
,
Antioxidants
,
Antiproliferative
,
Apoptotic
,
Cyclooxygenase 2 Inhibitors
,
DNA Repair Up-regulation
Additional Keywords
:
Gene Expression Regulation
[+]
Apple peel polyphenols and their beneficial actions on oxidative stress and inflammation.
Dec 31, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2013 ;8(1):e53725. Epub 2013 Jan 23. PMID:
23372666
Article Published Date
: Dec 31, 2012
Study Type
: In Vitro Study
Additional Links
Substances
:
Apple Pectin
Diseases
:
Inflammation
,
Lipid Peroxidation
,
Lipopolysaccharide-Induced Toxicity
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
,
Superoxide Dismutase Up-regulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Application of the solvent extraction technique to investigation of the anti-inflammatory activity of adlay bran.
Feb 14, 2014
Click here to read the entire abstract
Pubmed Data
: Food Chem. 2014 Feb 15 ;145:445-53. Epub 2013 Aug 27. PMID:
24128500
Article Published Date
: Feb 14, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
Adlay
Diseases
:
Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Plant Extracts
[+]
Aromatic-turmerone attenuates invasion and expression of MMP-9 and COX-2 through inhibition of NF-κB activation in TPA-induced breast cancer cells.
Nov 30, 2012
Click here to read the entire abstract
Pubmed Data
: J Cell Biochem. 2012 Dec ;113(12):3653-62. PMID:
22740037
Article Published Date
: Nov 30, 2012
Study Type
: In Vitro Study
Additional Links
Substances
:
Turmerones
Diseases
:
Breast Cancer
Pharmacological Actions
:
Anti-metastatic
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
NF-kappaB Inhibitor
[+]
Artemisinin may be a potentially useful therapeutic agent for inflammatory-related diseases.
Jan 31, 2017
Click here to read the entire abstract
Pubmed Data
: Immunopharmacol Immunotoxicol. 2017 Feb ;39(1):28-36. Epub 2016 Dec 21. PMID:
28000518
Article Published Date
: Jan 31, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Artemisinin
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Dose Response
[+]
Artesunate markedly inhibited gastric cancer cell proliferation in a time and dose dependent manner and induced apoptosis in gastric cancer cells a dose dependent manner.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Onco Targets Ther. 2015 ;8:845-54. Epub 2015 Apr 16. PMID:
25945055
Article Published Date
: Dec 31, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
Artesunate
,
Wormwood
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Dose Response
[+]
Arthrocen could potentially bring about the reduced pain produced by COX‐2 inhibitors without the known side effects of COX‐2 inhibition.
Jan 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: FEBS Open Bio. 2017 Feb ;7(2):187-194. Epub 2017 Jan 9. PMID:
28174685
Article Published Date
: Jan 31, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Avacado
Diseases
:
Osteoarthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Prostaglandin PGE2 downregulation
[+]
Astaxanthin attenuates the UVB-induced secretion of prostaglandin E(2) and interleukin-8, indicating its possible role in minimizing inflammation associated with skin damage.
Jul 01, 2012
Click here to read the entire abstract
Pubmed Data
: Exp Dermatol. 2012 Jul ;21 Suppl 1:11-7. PMID:
22626465
Article Published Date
: Jul 01, 2012
Study Type
: In Vitro Study
Additional Links
Substances
:
Astaxanthin
Diseases
:
Skin Diseases: Photo-Aging
,
Sunburn
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-8 downregulation
,
Prostaglandin PGE2 downregulation
[+]
Avocado soybean unsaponifiables and epigallocatechin gallate reduce inflammation in chondrocytes.
Dec 01, 2004
Click here to read the entire abstract
Pubmed Data
: J Chem Neuroanat. 2004 Dec;28(4):253-64. PMID:
19748608
Article Published Date
: Dec 01, 2004
Study Type
: In Vitro Study
Additional Links
Substances
:
Avocado
,
EGCG (Epigallocatechin gallate)
,
Soy
,
Unsaponifiables
Diseases
:
Osteoarthritis
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Prostaglandin Antagonists
[+]
Bamboo extracts exhibited anti-inflammatory properties by inhibiting NF-κB-induced gene expression.
Jan 31, 2014
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2014 Feb ;28(2):224-30. Epub 2013 Apr 5. PMID:
23559516
Article Published Date
: Jan 31, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
Bamboo
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 1 Inhibitor
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
Additional Keywords
:
Plant Extracts
[+]
Bee venom and its major component melittin reduce proinflammatory mediators in lipopolysaccharide-stimulated microglia.
Jan 01, 2010
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2010;62(2):148-53. PMID:
17570326
Article Published Date
: Jan 01, 2010
Study Type
: In Vitro Study
Additional Links
Substances
:
Bee Venom
Diseases
:
Brain: Microglial Activation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
NF-kappaB Inhibitor
[+]
Bee venom decreases LPS-induced inflammatory responses in bovine mammary epithelial cells.
Aug 16, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Microbiol Biotechnol. 2017 Aug 17. Epub 2017 Aug 17. PMID:
28813781
Article Published Date
: Aug 16, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Bee Venom
Diseases
:
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Betulinic acid inhibits hepatitis C virus replication by suppressing the NF-κB- and ERK1/2-mediated COX-2 pathway.
Jun 22, 2015
Click here to read the entire abstract
Pubmed Data
: Br J Pharmacol. 2015 Jun 23. Epub 2015 Jun 23. PMID:
26102077
Article Published Date
: Jun 22, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Betulinic acid
Diseases
:
Hepatitis C
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antiviral Agents
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
[+]
Black rice whole grain extracts exhibits therapeutic potential associated with the anthocyanin content in the extract for treating inflammatory diseases associated with cancer.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Asian Pac J Cancer Prev. 2015 ;16(10):4277-83. PMID:
26028086
Article Published Date
: Dec 31, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
Rice: Black
Diseases
:
Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Dose Response
[+]
Bromelain has anti-tumor initiating activity against skin cancer cells.
Sep 18, 2009
Click here to read the entire abstract
Pubmed Data
: Cancer Lett. 2009 Sep 18;282(2):167-76. Epub 2009 Mar 31. PMID:
19339108
Article Published Date
: Sep 18, 2009
Study Type
: In Vitro Study
Additional Links
Substances
:
Bromelain
Diseases
:
Skin Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Apoptotic
,
Bcl-2 protein down-regulation
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
[+]
Bromelain inhibits lipopolysaccharide-induced inflammation.
Jan 01, 2003
Click here to read the entire abstract
Pubmed Data
: J Huazhong Univ Sci Technolog Med Sci. 2003;23(2):151-3. PMID:
18569070
Article Published Date
: Jan 01, 2003
Study Type
: In Vitro Study
Additional Links
Substances
:
Bromelain
Diseases
:
Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Bromelain may have anti-skin tumor activity.
Jan 01, 2008
Click here to read the entire abstract
Pubmed Data
: Toxicol Appl Pharmacol. 2008 Jan 1;226(1):30-7. Epub 2007 Aug 23. PMID:
17889918
Article Published Date
: Jan 01, 2008
Study Type
: In Vitro Study
Additional Links
Substances
:
Bromelain
Diseases
:
Skin Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Apoptotic
,
Bcl-2 protein down-regulation
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
[+]
Butterbur (P. hybridus) exhibits ant-inflammatory activity in rat microglial (brain) cells.
Jan 01, 2005
Click here to read the entire abstract
Pubmed Data
: Planta Med. 2005 Jan;71(1):12-9. PMID:
15678367
Article Published Date
: Jan 01, 2005
Study Type
: In Vitro Study
Additional Links
Substances
:
Butterbur
Diseases
:
Brain: Microglial Activation
,
Brain Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Cyclooxygenase 1 Inhibitor
,
Cyclooxygenase 2 Inhibitors
,
Cyclooxygenase Inhibitors
,
Postaglandin PGE2 downregulation
Additional Keywords
:
Plant Extracts
[+]
C. obtusa f.formnosana wood oil had very good anti-inflammatory efficacies.
Apr 30, 2014
Click here to read the entire abstract
Pubmed Data
: Nat Prod Commun. 2014 May ;9(5):723-6. PMID:
25026733
Article Published Date
: Apr 30, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
Japanese cypress
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Plant Oils
[+]
Cannabidiolic acid abrogates the expression of COX-2 via the selective down-regulation of c-fos.
Aug 15, 2016
Click here to read the entire abstract
Pubmed Data
: J Nat Med. 2016 Aug 16. Epub 2016 Aug 16. PMID:
27530354
Article Published Date
: Aug 15, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Cannabis
Diseases
:
Breast Cancer: Triple Negative
Pharmacological Actions
:
Anti-metastatic
,
Cyclooxygenase 2 Inhibitors
[+]
Cannabidiolic acid had dual inhibitory effects on COX-2 through down-regulation and enzyme inhibition, and may suppress genes that are positively involved in the metastasis of cancer cells in vitro.
Dec 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Toxicol Sci. 2014 ;39(5):711-6. PMID:
25242400
Article Published Date
: Dec 31, 2013
Study Type
: In Vitro Study
Additional Links
Substances
:
Cannabis
Diseases
:
Breast Cancer
,
Breast Cancer: Metastatic
,
Breast Cancer: Triple Negative
Pharmacological Actions
:
Anti-metastatic
,
Cyclooxygenase 2 Inhibitors
,
Enzyme Inhibitors
Additional Keywords
:
Gene Expression Regulation
[+]
Cannabinoids may have a role to play in arthritis prevention and treatment.
Feb 28, 2006
Click here to read the entire abstract
Pubmed Data
: J Pharm Pharmacol. 2006 Mar ;58(3):351-8. PMID:
16536902
Article Published Date
: Feb 28, 2006
Study Type
: Review
Additional Links
Substances
:
Cannabinoids
Diseases
:
Arthritis
Pharmacological Actions
:
Cyclooxygenase 1 Inhibitor
,
Cyclooxygenase 2 Inhibitors
[+]
Capsaicin is a novel chemopreventive molecule.
Jan 01, 2010
Click here to read the entire abstract
Pubmed Data
: Indian J Cancer. 2010 Jan-Mar;47(1):53-8. PMID:
20071791
Article Published Date
: Jan 01, 2010
Study Type
: Commentary
Additional Links
Substances
:
Capsaicin
Diseases
:
Cancers: All
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
[+]
Celecoxib and curcumin work synergistically to inhibit the growth of colorectal cancer cells.
Sep 15, 2005
Click here to read the entire abstract
Pubmed Data
: Clin Cancer Res. 2005 Sep 15;11(18):6738-44. PMID:
16166455
Article Published Date
: Sep 15, 2005
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Colon Cancer
,
Colorectal Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cyclooxygenase 1 Inhibitor
,
Cyclooxygenase 2 Inhibitors
,
Cyclooxygenase Inhibitors
,
Prostaglandin PGE2 downregulation
Additional Keywords
:
Drug: Celecoxib
,
Drug Synergy
[+]
Chamomile is a novel and selective COX-2 inhibitor with anti-inflammatory activity.
Nov 04, 2009
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2009 Nov 4;85(19-20):663-9. Epub 2009 Sep 27. PMID:
19788894
Article Published Date
: Nov 04, 2009
Study Type
: In Vitro Study
Additional Links
Substances
:
Apigenin
,
Chamomile
Diseases
:
Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Natural Substances Versus Drugs
,
Plant Extracts
[+]
Chrysin suppresses lipopolysaccharide-induced inflammation.
Jan 31, 2005
Click here to read the entire abstract
Pubmed Data
: FEBS Lett. 2005 Jan 31;579(3):705-11. PMID:
15670832
Article Published Date
: Jan 31, 2005
Study Type
: In Vitro Study
Additional Links
Substances
:
Chrysin
,
Flavonoids
Diseases
:
Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
[+]
Clinical studies have reported that oral fish oil supplementation has beneficial effects in rheumatoid arthritis and among some asthmatics, supporting the idea that the n-3 FA in fish oil are anti-inflammatory
Mar 31, 2003
Click here to read the entire abstract
Pubmed Data
: Lipids. 2003 Apr ;38(4):343-52. PMID:
12848278
Article Published Date
: Mar 31, 2003
Study Type
: Review
Additional Links
Substances
:
Omega-3 Fatty Acids
Diseases
:
Asthma
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 1 Inhibitor
,
Cyclooxygenase 2 Inhibitors
,
Cyclooxygenase Inhibitors
[+]
Combined exosome-melatonin regimen was superior to either alone in protecting the liver against ischemia-reperfusion injury.
Dec 31, 2016
Click here to read the entire abstract
Pubmed Data
: Am J Transl Res. 2017 ;9(4):1543-1560. Epub 2017 Apr 15. PMID:
28469765
Article Published Date
: Dec 31, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Melatonin
Diseases
:
Liver Injury: Ischemia/reperfusion
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Exosomes
[+]
Compounds isolated from the twigs of Morus alba had anti-inflammatory effects.
May 17, 2017
Click here to read the entire abstract
Pubmed Data
: Fitoterapia. 2017 May 18 ;120:17-24. Epub 2017 May 18. PMID:
28529178
Article Published Date
: May 17, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Mulberry
Diseases
:
Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
[+]
Constituents of Asparagus officinalis have anti-inflammatory activity against the Cox-2 enzyme.
Apr 21, 2004
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2004 Apr 21;52(8):2218-22. PMID:
15080623
Article Published Date
: Apr 21, 2004
Study Type
: In Vitro Study
Additional Links
Substances
:
Asparagus
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
[+]
CoQ10 may have therapeutic potential for neurodegenerative diseases by inhibiting pro-inflammatory mediators production.
Apr 26, 2017
Click here to read the entire abstract
Pubmed Data
: Brain Res Bull. 2017 Apr 27 ;131:192-198. Epub 2017 Apr 27. PMID:
28458038
Article Published Date
: Apr 26, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Coenzyme Q10
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Postaglandin PGE2 downregulation
[+]
Cross-linked bromelain inhibits lipopolysaccharide-induced inflammation.
Mar 22, 2006
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2006 Mar 22;54(6):2193-8. PMID:
16536595
