Cyclooxygenase 2 Inhibitors

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176 Substances Researched for Cyclooxygenase 2 Inhibitors
NameACCKFocus
Curcumin6187Locked
Flavonoids1327Locked
Resveratrol1723Locked
Omega-3 Fatty Acids617Locked
Sulforaphane1114Locked
Apples212Locked
DHA (Docosahexaenoic Acid)312Locked
Spirulina212Locked
EPA (Eicosapentaenoic Acid)211Locked
Turmeric211Locked
Eicosapentaenoic acid (EPA) 110Locked
Frankincense110Locked
Polyphenols610Locked
Strawberry110Locked
Vitamin C110Locked
Stilbenes58Locked
Cannabis37Locked
Melatonin46Locked
Astaxanthin35Locked
Berberine35Locked
Chrysin35Locked
Ginger35Locked
Noni35Locked
Pterostilbene45Locked
Wogonin35Locked
Anthocyanins24Locked
Black Tea34Locked
Bromelain44Locked
Dandelion 44Locked
Flaxseed24Locked
Fucoidan34Locked
Ginkgo biloba24Locked
Lignans24Locked
Medium Chain Triglycerides24Locked
Nobiletin 34Locked
Palm Oil24Locked
Pomegranate34Locked
Quercetin34Locked
Saturated fatty acids24Locked
Sweet Potato: Purple24Locked
Thymoquinone24Locked
18β-Glycyrrhetinic Acid23Locked
Antrodia camphorata23Locked
Apigenin23Locked
Blueberry23Locked
Chaga Mushroom (Inonotus obliquus)23Locked
Chinese Skullcap 23Locked
Citrus Peel 23Locked
Fermented Foods and Beverages23Locked
Ginseng (American)23Locked
Ginseng (Korean)33Locked
Mangiferin23Locked
Rose 23Locked
Saffron23Locked
ALA (Alpha-Linolenic Acid)12Locked
Alpha Linolenic Acid12Locked
Apple Polyphenols12Locked
Arginine12Locked
Artemisia asiatica12Locked
Bee Propolis12Locked
Benzyl isothiocyanate 12Locked
Boswellia12Locked
Brown Rice12Locked
Burdock12Locked
Caffeic acid phenethyl ester12Locked
Carrot12Locked
Catechin 22Locked
Cocoa12Locked
Crocetin12Locked
Cyanidin 3-glucoside12Locked
Damnacanthal12Locked
EGCG (Epigallocatechin gallate)22Locked
Evening Primrose Oil12Locked
Fisetin22Locked
Fucoxanthin 12Locked
Garcinia indica12Locked
Gardenia12Locked
Garlic12Locked
Gingerol 12Locked
Grape Seed Extract12Locked
Graviola 12Locked
Guggul22Locked
Hops12Locked
Kaempferia parviflora12Locked
L-Carnitine12Locked
Lactobacillus rhamnosus 12Locked
Lion's Mane (Hericium Erinaceus)12Locked
Moringa oleifera12Locked
Mulberry12Locked
Myricetin12Locked
Noni leaf extract12Locked
Patchouli12Locked
Peony12Locked
Perilla 12Locked
Pine Needle12Locked
Polyunsaturated Fatty Acids (PUFAs)12Locked
Potato12Locked
Probiotics12Locked
Raspberry12Locked
Red Wine12Locked
Rice Bran12Locked
Rosmarinic acid12Locked
Royal Jelly12Locked
Rutin12Locked
Sour Cherry12Locked
Tangeretin 12Locked
Tongkat Ali12Locked
Walnut12Locked
Achillea fragrantissima11Locked
Alpha-Lipoic Acid11Locked
Artesunate11Locked
Asparagus11Locked
Avenanthramides11Locked
Avocado11Locked
Bamboo11Locked
Bee Venom11Locked
Beta-glucan11Locked
Betulinic acid11Locked
Black Pepper11Locked
Butterbur11Locked
Capsaicin11Locked
Chamomile11Locked
Cucurbitacin B 11Locked
Cumin11Locked
Cyanidin11Locked
Echinacea11Locked
Ferulic acid11Locked
Feverfew11Locked
Fish Oil11Locked
Fruit: All11Locked
Ginsenosides11Locked
Gleditsia sinensis11Locked
Guava11Locked
Horseradish11Locked
Huperzine11Locked
Hyaluronic Acid11Locked
Hydroxytyrosol11Locked
Kava Kava11Locked
Kimchi11Locked
Long Pepper11Locked
Loquat Leaves11Locked
Lutein11Locked
Luteolin11Locked
Maitake Mushroom11Locked
Medicinal Mushrooms11Locked
Mushrooms: All 11Locked
Mussel: Green-lipped (Perna canaliculus)11Locked
Oats11Locked
Oleuropein11Locked
Olive11Locked
Orange: Mandarin11Locked
Oranges11Locked
Phenethyl isothiocyanate11Locked
Piceatannol 11Locked
Piperlongumine 11Locked
Plantago11Locked
Prunella vulgaris.11Locked
Purple Carrots11Locked
Reishi Mushroom11Locked
Rice: Black 11Locked
Rose Hips11Locked
Saw Palmetto11Locked
Sesame Seeds11Locked
Soy11Locked
Tabebuia11Locked
Theaflavins11Locked
Tocotrienol: Gamma11Locked
Toona sinensis 11Locked
Truffles11Locked
Turmerones11Locked
Tyrosol11Locked
Unsaponifiables 11Locked
Ursolic Acid11Locked
Vegetables: All 11Locked
Wormwood11Locked
Wasabi10Locked

View the Evidence:
563 Abstracts with Cyclooxygenase 2 Inhibitors Research

[+]

A daily dose of 3.6 g curcumin achieves pharmacologically efficacious levels in the colorectum with negligible distribution of curcumin outside the gut.Jan 01, 2005

Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):120-5. PMID: 15668484
Article Published Date : Jan 01, 2005
Study Type : Human Study
Additional Links
Substances : Curcumin
Diseases : Colorectal Cancer
Pharmacological Actions : Chemopreventive, Cyclooxygenase 2 Inhibitors
Additional Keywords : Antineoplastic Agents
[+]

A formulation containing Frankincense and Turmeric extracts demonstrated a greater improvement in the treatment of OA than celecoxib.Oct 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2013 Nov ;8(5):1542-8. Epub 2013 Aug 29. PMID: 24002213
Article Published Date : Oct 31, 2013
Study Type : Human Study
Additional Links
Substances : Frankincense, Turmeric
Diseases : Osteoarthritis: Knee
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts, Superiority of Natural Substances versus Drugs
Problem Substances : Celecoxib, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Carbohydrate ingestion from bananas had positive influence in attenuating metabolic perturbation and inflammation following 75-km cycling.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2018 ;13(3):e0194843. Epub 2018 Mar 22. PMID: 29566095
Article Published Date : Dec 31, 2017
Study Type : Human Study
Additional Links
Substances : Banana
Therapeutic Actions : Exercise: Cycling
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
[+]

Consumption of dried apple peel powder was associated with improved joint function and improved serum antioxidant protection status.Oct 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Med Food. 2014 Nov ;17(11):1204-13. Epub 2014 Oct 1. PMID: 25271471
Article Published Date : Oct 31, 2014
Study Type : Human Study
Additional Links
Substances : Apples
Diseases : Joint Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Antinoceceptive , Antioxidants, Cyclooxygenase 2 Inhibitors, Lipoxygenase Inhibitors
Additional Keywords : Plant Extracts, Significant Treatment Outcome
[+]

Dietary strawberries significantly decreased the histologic grade of patients' precancerous esophageal lesions.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Prev Res (Phila). 2012 Jan ;5(1):41-50. Epub 2011 Dec 1. PMID: 22135048
Article Published Date : Dec 31, 2011
Study Type : Human Study
Additional Links
Substances : Strawberry
Diseases : Esophageal Cancer
Pharmacological Actions : Antiproliferative , Chemopreventive, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Nitric Oxide Inhibitor
Additional Keywords : Plant Extracts, Risk Reduction
[+]

Electroacupuncture may prevent ischemia-reperfusion-induced endothelial dysfunction via a COX-2 dependent mechanism.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(6):e0178838. Epub 2017 Jun 7. PMID: 28591155
Article Published Date : Dec 31, 2016
Study Type : Human Study
Additional Links
Diseases : Endothelial Dysfunction, Ischemia
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Cyclooxygenase 2 Inhibitors
[+]

Electroacupuncture treatment alleviates central post-stroke pain.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neural Plast. 2016 ;2016:1437148. Epub 2016 Aug 27. PMID: 27774321
Article Published Date : Dec 31, 2015
Study Type : Human Study
Additional Links
Diseases : Stroke: Attenuation/Recovery
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Analgesics, Cyclooxygenase 2 Inhibitors
[+]

EPA supplementation significantly reduces Cox-2 enzyme expression in Barrett's esophagus.Apr 01, 2008

Pubmed Data : Am J Clin Nutr. 2008 Apr;87(4):949-56. PMID: 18400718
Article Published Date : Apr 01, 2008
Study Type : Human Study
Additional Links
Substances : EPA (Eicosapentaenoic Acid)
Diseases : Barrett Esophagus
Pharmacological Actions : Cyclooxygenase 2 Inhibitors
[+]

Omega-3 fatty acids cause a reduction in the mRNA levels for various proteins known to be important in the pathology of osteoarthritis. Jul 01, 2009

Pubmed Data : Osteoarthritis Cartilage. 2009 Jul;17(7):896-905. Epub 2009 Jan 13. PMID: 19217322
Article Published Date : Jul 01, 2009
Study Type : Human Study
Additional Links
Substances : DHA (Docosahexaenoic Acid), Eicosapentaenoic acid (EPA) , Omega-3 Fatty Acids
Diseases : Osteoarthritis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Phloretin inhibits the growth of P. acnes, P. granulosum, and S. epidermidis.Jan 31, 2016

Pubmed Data : Int J Cosmet Sci. 2016 Feb ;38(1):85-92. Epub 2015 Aug 30. PMID: 26212527
Article Published Date : Jan 31, 2016
Study Type : Human In Vitro, Human Study
Additional Links
Substances : Phloretin
Diseases : Acne
Pharmacological Actions : Anti-Bacterial Agents, Antimicrobial, Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation
[+]

Pycnogenol may be of value in treatment of MSU crystal-induced arthritis through its anti-inflammatory and anti-nitrosative activities.Feb 14, 2012

Pubmed Data : Free Radic Biol Med. 2012 Feb 15 ;52(4):765-74. Epub 2011 Dec 13. PMID: 22198264
Article Published Date : Feb 14, 2012
Study Type : Human Study
Additional Links
Substances : Flavonoids
Diseases : Gout, Hyperuricemia
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
[+]

Spirulina has favorable effects on lipid profiles, immune variables and antioxidant capacity in healthy individuals.Jan 01, 2008

Pubmed Data : Ann Nutr Metab. 2008;52(4):322-8. Epub 2008 Aug 19. PMID: 18714150
Article Published Date : Jan 01, 2008
Study Type : Human Study
Additional Links
Substances : Spirulina
Diseases : High Cholesterol
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-2 upregulation, Interleukin-6 Downregulation
[+]

The anti-inflammatory activity of Cannabis extracts on colon epithelial cells derives from a fraction of the extract that contains THCA.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cannabis Cannabinoid Res. 2017 ;2(1):167-182. Epub 2017 Jul 1. PMID: 29082314
Article Published Date : Dec 31, 2016
Study Type : Human Study
Additional Links
Substances : Cannabinoids , Cannabis
Diseases : Inflammatory Bowel Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

These new data support a potential role of oleuropein in the treatment of ulcerative colitis.Apr 14, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2017 Apr 15 ;9(4). Epub 2017 Apr 15. PMID: 28420140
Article Published Date : Apr 14, 2017
Study Type : Human Study
Additional Links
Substances : Oleuropein
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-17 downregulation
[+]

Vitamin C attenuates aspirin-induced gastric damage. May 01, 2009

Pubmed Data : Zhongguo Zhen Jiu. 2009 May;29(5):382-4. PMID: 17218764
Article Published Date : May 01, 2009
Study Type : Human Study
Additional Links
Substances : Vitamin C
Diseases : Aspirin-Induced Toxicity , NSAID-induced toxicity
Pharmacological Actions : Cyclooxygenase 2 Inhibitors
[+]

Cannabidiolic acid an active component in the cannabis plant offers potential therapeutic modality in the abrogation of cancer cell migration.Nov 14, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxicol Lett. 2012 Nov 15 ;214(3):314-9. Epub 2012 Sep 8. PMID: 22963825
Article Published Date : Nov 14, 2012
Study Type : Human In Vitro
Additional Links
Substances : Cannabis
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Antiproliferative , Cyclooxygenase 2 Inhibitors, Enzyme Inhibitors
[+]

Ginsenoside Rg1 can inhibit inflammatory responses in human chondrocytes in vitro and reduce articular cartilage damage in vivo.Mar 09, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2017 Mar 10 ;9(3). Epub 2017 Mar 10. PMID: 28287423
Article Published Date : Mar 09, 2017
Study Type : Animal Study, Human In Vitro
Additional Links
Substances : Ginsenosides
Diseases : Osteoarthritis
Pharmacological Actions : Chondroprotective, Cyclooxygenase 2 Inhibitors, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Prostaglandin PGE2 downregulation
[+]

Melatonin as a novel selective ATF-6 inhibitor can sensitize human hepatoma cells to ER stress inducing apoptosis.Feb 13, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2017 Feb 14 ;23(6):986-998. PMID: 28246472
Article Published Date : Feb 13, 2017
Study Type : Human In Vitro
Additional Links
Substances : Melatonin
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Cyclooxygenase 2 Inhibitors
[+]

Melatonin is a potential candidate compound for the treatment of proinflammatory disorders.Aug 31, 2012

Pubmed Data : J Pineal Res. 2012 Sep ;53(2):154-65. Epub 2012 Feb 21. PMID: 22348531
Article Published Date : Aug 31, 2012
Study Type : Human In Vitro
Additional Links
Substances : Melatonin
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Dose Response
[+]

Oleuropein might provide a basis for developing a new dietary strategy for the prevention and management of rheumatoid arthritis.Apr 19, 2017

Pubmed Data : Food Funct. 2017 Apr 20. Epub 2017 Apr 20. PMID: 28426090
Article Published Date : Apr 19, 2017
Study Type : Human In Vitro
Additional Links
Substances : Oleuropein
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Matrix metalloproteinase-1 (MMP-1) inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Phloretin inhibits interleukin-1β-induced COX-2 and ICAM-1 in human lung epithelial cells.May 31, 2015

Pubmed Data : Food Funct. 2015 Jun ;6(6):1960-7. PMID: 25996641
Article Published Date : May 31, 2015
Study Type : Human In Vitro
Additional Links
Substances : Phloretin
Diseases : Experimental Lung Inflammation
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Prostaglandin PGE2 downregulation
[+]

Resveratrol functions as a suppressor of particulate matter induced inflammatory signalling pathways.May 07, 2017

Pubmed Data : Int J Biochem Cell Biol. 2017 May 8 ;88:113-123. Epub 2017 May 8. PMID: 28495310
Article Published Date : May 07, 2017
Study Type : Human In Vitro
Additional Links
Substances : Resveratrol
Diseases : Air Pollution Linked Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation
[+]

Berberine suppresses growth and metastasis of endometrial cancer cells.Jun 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2018 Jul ;103:1287-1293. Epub 2018 May 7. PMID: 29864910
Article Published Date : Jun 30, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Berberine
Diseases : Endometrial Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation
[+]

Ginsenoside Rg1 might be an effective approach for the prevention against acute liver injury.Jul 01, 2018

Pubmed Data : Environ Toxicol. 2018 Jul 2. Epub 2018 Jul 2. PMID: 29964319
Article Published Date : Jul 01, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Molecular characterization of the grape seeds extract's effect against chemically induced liver cancer.Jan 18, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2018 Jan 19 ;8(1):1270. Epub 2018 Jan 19. PMID: 29352129
Article Published Date : Jan 18, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Grape Seed Extract
Diseases : Liver Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors
[+]

White rose petal extract could be a good candidate as an anti-epileptic or neuroprotective agent.Sep 25, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2018 Sep 26 ;10(10). Epub 2018 Sep 26. PMID: 30261613
Article Published Date : Sep 25, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Rose
Diseases : Brain Inflammation , Seizures
Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Berberin inhibited colorectal cancer invasion and metastasis via down regulation of COX-2/PGE2- JAK2/STAT3 signaling pathway.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(5):e0123478. Epub 2015 May 8. PMID: 25954974
Article Published Date : Dec 31, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Berberine
Diseases : Colorectal Cancer
Pharmacological Actions : Anti-metastatic, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Prostaglandin PGE2 downregulation
[+]

"Chrysin abrogates early hepatocarcinogenesis and induces apoptosis in N-nitrosodiethylamine-induced preneoplastic nodules in rats."Feb 15, 2011

Pubmed Data : Toxicol Appl Pharmacol. 2011 Feb 15 ;251(1):85-94. Epub 2010 Dec 15. PMID: 21167192
Article Published Date : Feb 15, 2011
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Liver Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors, Tumor Suppressor Protein p53 Upregulation
[+]

18β-Glycyrrhetinic acid significantly attenuated H. pylori-infected gastritis in gerbils.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2016 ;2016:4943793. Epub 2016 Feb 24. PMID: 27006947
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : 18β-Glycyrrhetinic Acid
Diseases : Helicobacter Pylori Infection
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Gastroprotective, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

5-FU and thymoquinone combination therapy resulted in a more significant reduction on AOM-induced colorectal tumors.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2016 ;10:2239-53. Epub 2016 Jul 11. PMID: 27468227
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Colorectal Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemoprotective Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Vascular Endothelial Growth Factor Inhibitors, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Gene Expression Regulation
[+]

6-gingerol prevented DSS-induced chronic ulcerative colitis via anti-inflammatory and antioxidative mechanisms.Dec 31, 2017

Pubmed Data : Hum Exp Toxicol. 2018 Jan 1:960327117751235. Epub 2018 Jan 1. PMID: 29350052
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Gingerol
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

A Burdock extract was able to reduce intestinal inflammation in an acute TNBS-induced experimental model of colitis in rats.Mar 06, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Ethnopharmacol. 2013 Mar 7 ;146(1):300-10. Epub 2013 Jan 10. PMID: 23313393
Article Published Date : Mar 06, 2013
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Phytotherapy, Plant Extracts
[+]

A combination of ginger and peony root may prevent memory impairment in AD by inhibiting Aβ accumulation and inflammation in the brain.Nov 29, 2015

Pubmed Data : J Alzheimers Dis. 2015 Nov 30. Epub 2015 Nov 30. PMID: 26639976
Article Published Date : Nov 29, 2015
Study Type : Transgenic Animal Study
Additional Links
Substances : Ginger, Peony
Diseases : Alzheimer's Disease, Brain Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts
[+]

A polyphenol-rich cranberry extract reverses insulin resistance and hepatic steatosis independently of body weight loss.Nov 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Metab. 2017 Dec ;6(12):1563-1573. Epub 2017 Oct 18. PMID: 29107524
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Cranberry
Diseases : Insulin Resistance
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Açaí demonstrated protective effects against AOM/DSS-induced colon carcinogenesis.Mar 14, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Gut Liver. 2017 Mar 15 ;11(2):243-252. PMID: 27965474
Article Published Date : Mar 14, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Acai
Diseases : Colon Cancer, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Adlay bran ethanolic extract suppressed 1,2-dimethylhydrazine-indued preneoplastic lesions of the colon.Jul 13, 2010

Pubmed Data : J Agric Food Chem. 2010 Jul 14 ;58(13):7616-23. PMID: 20536243
Article Published Date : Jul 13, 2010
Study Type : Animal Study
Additional Links
Substances : Adlay
Diseases : Colon Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors
Additional Keywords : Adlay, Anti-Inflammatory Agents, Chemopreventive, COLON CANCER, Cyclooxygenase 2 Inhibitors, Plant Extracts
[+]

Allylmethylsulfide (AMS), a volatile organosulfur derivative from garlic has radioprotective properties.Jun 01, 2009

Pubmed Data : J Med Food. 2009 Jun;12(3):542-51. PMID: 19627202
Article Published Date : Jun 01, 2009
Study Type : Animal Study
Additional Links
Substances : Garlic
Diseases : Lipid Peroxidation, Radiation Induced Illness
Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Radioprotective, Vascular Cell Adhesion Molecule-1 Inhibitor
Additional Keywords : Plant Extracts
[+]

Alpha linolenic fatty acid supplementation had a beneficial effect on tumor cell proliferation and cachexia parameters.May 25, 2015

Pubmed Data : Nutr Cancer. 2015 May 26:1-8. Epub 2015 May 26. PMID: 26011096
Article Published Date : May 25, 2015
Study Type : Animal Study
Additional Links
Substances : Alpha Linolenic Acid
Diseases : Breast Cancer, Cachexia
Pharmacological Actions : Antiproliferative , Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Alpha lipoic acid has hepatoprotective effects against methotrexate-induced hepatic injury.Jun 03, 2018

Pubmed Data : Biomed Pharmacother. 2018 Jun 4 ;105:428-433. Epub 2018 Jun 4. PMID: 29879626
Article Published Date : Jun 03, 2018
Study Type : Animal Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Drug-Induced Toxicity: Methotrexate
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 inducer, Hepatoprotective, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

American ginseng prevents and treats Ulcerative Colitis.Sep 18, 2008

Pubmed Data : Carcinogenesis. 2008 Sep 18. [Epub ahead of print] PMID: 18802031
Article Published Date : Sep 18, 2008
Study Type : Animal Study
Additional Links
Substances : Ginseng (American)
Diseases : Colitis: Pseudomembranous, Ulcerative Colitis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Nitric Oxide Inhibitor, Tumor Suppressor Protein p53 Upregulation
[+]

Antarctic krill oil diet protects against lipopolysaccharide-induced oxidative stress, neuroinflammation and cognitive impairment.Nov 27, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2017 Nov 28 ;18(12). Epub 2017 Nov 28. PMID: 29182579
Article Published Date : Nov 27, 2017
Study Type : Animal Study
Additional Links
Substances : Krill
Diseases : Alzheimer's Disease, Brain: Oxidative Stress, Brain Inflammation , Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Neuroprotective Agents
[+]

Anthocyanin-rich fractions from red raspberries attenuate inflammation both in vitro and in vivo.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2014 ;4:6234. Epub 2014 Aug 29. PMID: 25167935
Article Published Date : Dec 31, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Anthocyanins, Raspberry
Diseases : Colitis, Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor
Additional Keywords : Plant Extracts
[+]

Anthocyanins from black chokeberry delayed aging-related degenerative changes of the brain.Jul 25, 2017

Pubmed Data : J Agric Food Chem. 2017 Jul 26 ;65(29):5973-5984. Epub 2017 Jul 12. PMID: 28657734
Article Published Date : Jul 25, 2017
Study Type : Animal Study
Additional Links
Substances : Anthocyanins, Chokeberry
Diseases : Aging: Brain , Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts
[+]

Anti-inflammatory mechanisms could be involved in pomegranate-mediated prevention of breast cancer.Apr 27, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2017 Apr 28 ;9(5). Epub 2017 Apr 28. PMID: 28452959
Article Published Date : Apr 27, 2017
Study Type : Animal Study
Additional Links
Substances : Pomegranate
Diseases : Breast Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Heat Shock Protein Down-Regulation
[+]

Antrodia camphorata extract, when combined with anti-tumor agents, showed adjuvant antiproliferative effects on multi-drug resistant hepatoma. Aug 13, 2008

Pubmed Data : J Ethnopharmacol. 2008 Aug 13;118(3):387-95. Epub 2008 May 7. PMID: 18571350
Article Published Date : Aug 13, 2008
Study Type : Animal Study
Additional Links
Substances : Antrodia camphorata
Diseases : Cancers: Multi-Drug Resistant, Liver Cancer
Pharmacological Actions : Antineoplastic Agents, Cell cycle arrest, Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts
[+]

Apigenin and myricetin exhibited a protective and promising preventive strategy against cisplatin-induced nephrotoxicity.Nov 30, 2017

Pubmed Data : Pharm Biol. 2017 Dec ;55(1):766-774. PMID: 28064632
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Apigenin, Flavonoids, Myricetin
Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Oxidative Stress
Pharmacological Actions : Chemoprotective Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Apigenin, a dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation in mice. Jan 01, 2009

Pubmed Data : Arthritis Res Ther. 2009;11(2):R59. Epub 2009 Apr 30. PMID: 19405952
Article Published Date : Jan 01, 2009
Study Type : Animal Study
Additional Links
Substances : Apigenin
Diseases : Autoimmune Diseases, Lupus Erythematosus: Systemic
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Apple polyphenols extract (APE) improves colon damage in a rat model of colitis.Feb 28, 2012

Pubmed Data : Dig Liver Dis. 2012 Feb 28. Epub 2012 Feb 28. PMID: 22381211
Article Published Date : Feb 28, 2012
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols
Diseases : Colitis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Apples rich polyphenols reduce colonic inflammation in rats. Dec 01, 2009

Pubmed Data : Br J Nutr. 2009 Dec;102(11):1620-8. Epub 2009 Jul 22. PMID: 19622193
Article Published Date : Dec 01, 2009
Study Type : Transgenic Animal Study
Additional Links
Substances : Apples, Flavonoids, Polyphenols
Diseases : Inflammatory Bowel Diseases, Irritable Bowel Syndrome
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
[+]

Arctigenin exerts protective effects against myocardial infarction.Feb 28, 2018

Pubmed Data : Mol Med Rep. 2018 Mar ;17(3):4839-4845. Epub 2018 Jan 10. PMID: 29328478
Article Published Date : Feb 28, 2018
Study Type : Animal Study
Additional Links
Substances : Arctigenin
Diseases : Myocardial Infarction
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation
Additional Keywords : Anti-Inflammatory Agents, Antioxidants, Arctigenin, Myocardial Infarction
[+]

Arginine reverses ethanol-induced inflammatory and fibrotic changes in liver despite continued ethanol administration.Dec 01, 2001

Pubmed Data : J Pharmacol Exp Ther. 2001 Dec;299(3):832-9. PMID: 11714866
Article Published Date : Dec 01, 2001
Study Type : Animal Study
Additional Links
Substances : Arginine
Diseases : Alcoholic Liver Disease, Inflammation, Liver Fibrosis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Artemisia extracts were mucoprotective by attenuating stress related mucosal damages.Feb 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Biochem Nutr. 2015 Mar ;56(2):132-42. Epub 2014 Nov 28. PMID: 25759519
Article Published Date : Feb 28, 2015
Study Type : Animal Study
Additional Links
Substances : Artemisia asiatica
Diseases : Gastrointestinal Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Gastroprotective, Nrf2 activation
Additional Keywords : Dose Response
[+]

Ascorbic acid contributes to the reduction of oxidative stress and inflammatory response in DSS-induced colitis.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Clin Exp Med. 2015 ;8(11):20245-53. Epub 2015 Nov 15. PMID: 26884937
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Gastrointestinal Inflammation, Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Superoxide Dismutase Up-regulation
[+]

Asiatic acid is a potent nutraceutical agent against the progression of Parkinson's disease.Mar 31, 2016

Pubmed Data : Food Funct. 2016 Apr ;7(4):1999-2005. PMID: 26999333
Article Published Date : Mar 31, 2016
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Parkinson's Disease
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Astaxanthin could be a promising agent for atopic dermatitis by inhibition of NF-κB signalling.Sep 07, 2017

Pubmed Data : Exp Dermatol. 2017 Sep 8. Epub 2017 Sep 8. PMID: 28887839
Article Published Date : Sep 07, 2017
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Atopic Dermatitis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Astaxanthin exhibits anti-inflammatory and anti-cancer activity in a rat model of colon cnacer.Apr 01, 2011

Pubmed Data : Invest New Drugs. 2011 Apr;29(2):207-24. Epub 2009 Oct 30. PMID: 19876598
Article Published Date : Apr 01, 2011
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Cancer Metastasis, Colon Cancer, Colorectal Cancer, Inflammation
Pharmacological Actions : Apoptotic, Chemopreventive, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Astaxanthin had an anti-depressant effect on diabetic mice.Dec 21, 2016

Pubmed Data : Brain Res. 2016 Dec 22. Epub 2016 Dec 22. PMID: 28017669
Article Published Date : Dec 21, 2016
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Brain Inflammation , Depression, Diabetic Complications
Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Prophylactic Agents
[+]

Astragaloside IV protects rat gastric mucosa against aspirin-induced damage.Nov 30, 2016

Pubmed Data : Int Immunopharmacol. 2016 Dec ;41:47-55. Epub 2016 Nov 2. PMID: 27816726
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Aspirin-Induced Toxicity , Gastric Ulcer, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Gastroprotective, Superoxide Dismutase Up-regulation
Problem Substances : Aspirin
[+]

Astragaloside IV suppresses inflammatory mediator production in synoviocytes and collagen‑induced arthritic rats.Mar 31, 2016

Pubmed Data : Mol Med Rep. 2016 Apr ;13(4):3289-96. Epub 2016 Feb 22. PMID: 26936538
Article Published Date : Mar 31, 2016
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Arthritis, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Atractylodes macrocephala or Taraxacum herba extracts can be considered natural agents that can prevent inflammatory bowel disease relapse.Sep 14, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Gut Liver. 2017 Sep 15 ;11(5):655-666. PMID: 28651306
Article Published Date : Sep 14, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Bai Zhu, Dandelion
Diseases : Colitis, Inflammatory Bowel Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts, Risk Reduction, Superiority of Natural Substances versus Drugs
[+]

Barley sprouts have a protective effect against alcohol-induced liver injury.Jul 20, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2016 Jul 21 ;8(7). Epub 2016 Jul 21. PMID: 27455313
Article Published Date : Jul 20, 2016
Study Type : Animal Study
Additional Links
Substances : Barley
Diseases : Alcohol Toxicity , Chemically-Induced Liver Damage, Lipopolysaccharide-Induced Toxicity, Oxidative Stress
Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, Hepatoprotective
Additional Keywords : Plant Extracts
[+]

Benzyl isothiocyanate and sulforaphane protect against initiation of pancreatic carcinogenesis in hamsters.Sep 28, 2006

Pubmed Data : Cancer Lett. 2006 Sep 28;241(2):275-80. Epub 2006 Jan 4. PMID: 16386831
Article Published Date : Sep 28, 2006
Study Type : Animal Study
Additional Links
Substances : Benzyl isothiocyanate , Sulforaphane
Diseases : Pancreatic Cancer
Pharmacological Actions : Chemopreventive, Cyclooxygenase 2 Inhibitors
Additional Keywords : Isothiocyanates, Stilbenes
[+]

Berberine chloride ameliorates oxidative stress, inflammation and apoptosis in the pancreas of Streptozotocin induced diabetic rats.Aug 22, 2017

Pubmed Data : Biomed Pharmacother. 2017 Aug 23 ;95:175-185. Epub 2017 Aug 23. PMID: 28843149
Article Published Date : Aug 22, 2017
Study Type : Animal Study
Additional Links
Substances : Berberine
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Hypoglycemic Agents, NF-kappaB Inhibitor, Pancreato Protective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Diabetes Mellitus: Type 1
[+]

Berberine has a preventive effect on experimental colon cancer. Oct 01, 2010

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2010 Oct;35(20):2768-73. PMID: 21246838
Article Published Date : Oct 01, 2010
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Colon Cancer
Pharmacological Actions : Chemopreventive, Cyclooxygenase 2 Inhibitors
[+]

Beta-caryophyllene constitutes an alluring therapeutic molecule towards the treatment of multiple sclerosis.Mar 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2017 Apr 1 ;18(4). Epub 2017 Apr 1. PMID: 28368293
Article Published Date : Mar 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Inflammation: Brain, Multiple Sclerosis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Immunomodulatory, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
Additional Keywords : Cannabinoid Receptors
[+]

Black Adzuki bean attenuates high-fat diet-induced colon inflammation.Mar 31, 2017

Pubmed Data : J Med Food. 2017 Apr ;20(4):367-375. PMID: 28406732
Article Published Date : Mar 31, 2017
Study Type : Animal Study
Additional Links
Substances : Aduki bean
Diseases : Colitis, High Fat Diet, Inflammation, Lipopolysaccharide-Induced Toxicity, Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Boswellia serrate extract has great potential to suppress colon tumorigenesis.Feb 27, 2017

Pubmed Data : Mol Nutr Food Res. 2017 Feb 28. Epub 2017 Feb 28. PMID: 28245338
Article Published Date : Feb 27, 2017
Study Type : Animal Study
Additional Links
Substances : Frankincense
Diseases : Colon Cancer, Colon Cancer: Prevention
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors
[+]

Boswellic acid suppresses growth and metastatis of human pancreatic tumors (nude mouse model). Jan 01, 2011

Pubmed Data : PLoS One. 2011 ;6(10):e26943. Epub 2011 Oct 31. PMID: 22066019
Article Published Date : Jan 01, 2011
Study Type : Transgenic Animal Study
Additional Links
Substances : Boswellia
Diseases : Cancer Metastasis, Pancreatic Cancer
Pharmacological Actions : Anti-metastatic, Apoptotic, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor Inhibitors
[+]

Both indole-3-carbinol and myo-inositol inhibit the development of vinyl carbamate induced pulmonary adenocarcinoma in mice.Jan 31, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Carcinogenesis. 2010 Feb ;31(2):239-45. Epub 2009 Jul 22. PMID: 19625346
Article Published Date : Jan 31, 2010
Study Type : Animal Study
Additional Links
Substances : Indole-3-Carbinol, Myo-inositol
Diseases : Lung Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors
Problem Substances : Vinyl Carbamate
[+]

C. obtusa essential oil may constitute a novel source of anti-inflammatory treatments. Jun 30, 2013

Pubmed Data : Mol Med Rep. 2013 Jul ;8(1):255-9. Epub 2013 May 8. PMID: 23652412
Article Published Date : Jun 30, 2013
Study Type : Animal Study
Additional Links
Substances : Japanese cypress
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Oils
[+]

Caffeic acid phenethyl ester, a compound found within propolis causes regression of experimental endometriosis.Apr 01, 2007

Pubmed Data : Reprod Sci. 2007 Apr;14(3):270-9. PMID: 17636241
Article Published Date : Apr 01, 2007
Study Type : Animal Study
Additional Links
Substances : Bee Propolis, Caffeic acid phenethyl ester
Diseases : Endometriosis
Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors
[+]

Camel milk attenuates rheumatoid arthritis in animals. Sep 19, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2017 Sep 20 ;43(2):540-552. Epub 2017 Sep 20. PMID: 28930753
Article Published Date : Sep 19, 2017
Study Type : Animal Study
Additional Links
Substances : Camel Milk
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-10 upregulation, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Cannabidiol could be used to prevent experimental colitis in mice.Oct 31, 2009

Pubmed Data : J Mol Med (Berl). 2009 Nov ;87(11):1111-21. Epub 2009 Aug 20. PMID: 19690824
Article Published Date : Oct 31, 2009
Study Type : Animal Study
Additional Links
Substances : Cannabidiol, Cannabis
Diseases : Colitis
Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-10 downregulation, Interleukin-1 beta downregulation
[+]

Carnosol protects against spinal cord injury through Nrf-2 upregulation.Dec 31, 2015

Pubmed Data : J Recept Signal Transduct Res. 2016 ;36(1):72-8. Epub 2015 Jul 6. PMID: 26791582
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Carnosol
Diseases : Oxidative Stress, Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Nrf2 activation
[+]

Carrot seeds contain phytochemicals capable of inhibiting inflammatory enzymes.Jun 01, 2007

Pubmed Data : Carcinogenesis. 2007 Jun;28(6):1188-96. Epub 2006 Dec 6. PMID: 13680840
Article Published Date : Jun 01, 2007
Study Type : Animal Study
Additional Links
Substances : Carrot
Pharmacological Actions : Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors
[+]

Carvacrol can be used as a protective agent against benzo(a)pyrene-induced lung toxicity and inflammation.Dec 31, 2016

Pubmed Data : Hum Exp Toxicol. 2017 Jan 1:960327117735572. Epub 2017 Jan 1. PMID: 29019276
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Carvacrol
Diseases : Benzo[a]pyrene-induced Toxicity , Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
Problem Substances : Benzo(a)pyrene
[+]

Chamaecyparis obtusa essential oil has anti-inflammatory and anti-nociceptive effects on arthritis in rats.Dec 31, 2014

Pubmed Data : Biosci Biotechnol Biochem. 2015 ;80(1):203-9. Epub 2015 Aug 19. PMID: 26581235
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Japanese cypress
Diseases : Arthritis
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Antinoceceptive , Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Essential Oils
[+]

Chemopreventive effects of Eryngium foetidum L. leaves on COX-2 reduction in mice induced colorectal carcinogenesis.Dec 31, 2015

Pubmed Data : Nutr Cancer. 2016 ;68(1):144-53. Epub 2016 Jan 15. PMID: 26771664
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Thistle
Diseases : Colorectal Cancer
Pharmacological Actions : Chemopreventive, Cyclooxygenase 2 Inhibitors
Additional Keywords : Phytotherapy
[+]

Chinese skullcap (Scutellaria baicalensis) significantly improves functional recovery from spinal cord injury in rats by inhibiting inflammation and oxidative stress after injury.Aug 01, 2009

Pubmed Data : J Neurochem. 2009 Aug;110(4):1276-87. Epub 2009 Jun 10. PMID: 19519665
Article Published Date : Aug 01, 2009
Study Type : Animal Study
Additional Links
Substances : Chinese Skullcap
Diseases : Brain: Microglial Activation, Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Apoptotic, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Nitric Oxide Inhibitor
Additional Keywords : Plant Extracts
[+]

Cocoa may merit further clinical investigation as a chemopreventive agent that helps prevent colitis-associated cancer. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biofactors. 2015 Jan-Feb;41(1):1-14. Epub 2014 Dec 24. PMID: 25545372
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Cocoa
Diseases : Colorectal Cancer, Colorectal Cancer: Prevention , Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Nrf2 activation
[+]

Cocoa polyphenols may inhibit tumor promotion through antioxidant and antiinflammatory mechanisms.May 01, 2006

Pubmed Data : J Nutr. 2006 May;136(5):1150-5. PMID: 16614396
Article Published Date : May 01, 2006
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Polyphenols
Diseases : Tumors
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Combination of Pelargonium sidoides and Coptis chinensis root inhibits nuclear factor kappa B-mediated inflammatory responses.Jan 18, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2018 Jan 19 ;18(1):20. Epub 2018 Jan 19. PMID: 29351747
Article Published Date : Jan 18, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Coptis chinensis, Pelargonium sidoides
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Compounds present in grape juice could reduce the inflammatory effects induced by experimental colitis.Feb 28, 2014

Pubmed Data : Environ Toxicol Pharmacol. 2014 Mar ;37(2):819-27. Epub 2014 Feb 26. PMID: 24637249
Article Published Date : Feb 28, 2014
Study Type : Animal Study
Additional Links
Substances : Grape
Diseases : Colitis, DNA damage
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Phytotherapy, Plant Extracts
[+]

COX2 expression in HPV16-induced lesions may be modulated by nutraceuticals.Dec 31, 2017

Pubmed Data : Anticancer Res. 2018 03 ;38(3):1461-1466. PMID: 29491072
Article Published Date : Dec 31, 2017
Study Type : Transgenic Animal Study
Additional Links
Substances : Curcumin, Rutin
Diseases : Human Papillomavirus (HPV), Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors
[+]

Crocetin supplementation in the MCA mice also showed protection against cervical cancer. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2015 ;2015:829513. Epub 2015 Mar 22. PMID: 25874230
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Cervical Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Crocin, a carotenoid fround within Gardenia jasminoides and Crocus sativus (Safron) has significant anti-inflammatory activity. Sep 23, 2009

Pubmed Data : J Agric Food Chem. 2009 Sep 23;57(18):8325-30. PMID: 19754168
Article Published Date : Sep 23, 2009
Study Type : Animal Study
Additional Links
Substances : Gardenia, Saffron
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors, Prostaglandin Antagonists
[+]

Curcumin ameliorates doxorubicin-induced cardiotoxicity.Jan 31, 2018

Pubmed Data : J Biochem Mol Toxicol. 2018 Feb ;32(2). Epub 2018 Jan 5. PMID: 29315967
Article Published Date : Jan 31, 2018
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents, Cyclooxygenase 2 Inhibitors
[+]

Curcumin ameliorates experimentally induced ulcerative colitis. Mar 01, 2007

Pubmed Data : Int Immunopharmacol. 2007 Mar;7(3):333-42. Epub 2006 Dec 18. PMID: 17276891
Article Published Date : Mar 01, 2007
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Colitis, Ulcerative Colitis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Curcumin attenuated glucose intolerance and insulin resistance through its antioxidant and anti-inflammatory effects.Dec 19, 2015

Pubmed Data : Chem Biol Interact. 2015 Dec 20. Epub 2015 Dec 20. PMID: 26713546
Article Published Date : Dec 19, 2015
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : C-Reactive Protein, Diabetes Mellitus: Type 2, Inflammation, Insulin Resistance, Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Curcumin can enhance postsynaptic electrical reactivity and cell viability in intact neural circuits with antidepressant-like effects.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mediators Inflamm. 2017 ;2017:6280925. Epub 2017 Jan 11. PMID: 28167853
Article Published Date : Dec 31, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Depression
Pharmacological Actions : Antidepressive Agents, Cyclooxygenase 2 Inhibitors
Additional Keywords : Antidepressive Agents, CURCUMIN, Cyclooxygenase 2 Inhibitors, depression
[+]

Curcumin has therapeutic effects in chemically-induced colitis. Jun 28, 2006

Pubmed Data : World J Gastroenterol. 2006 Jun 28;12(24):3848-53. PMID: 16804969
Article Published Date : Jun 28, 2006
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Colitis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Curcumin inhibits NF-kappaB activation and reduces the severity of experimental fatty liver in mice.Dec 01, 2003

Pubmed Data : Mech Ageing Dev. 2003 Dec;124(10-12):1025-34. PMID: 15582125
Article Published Date : Dec 01, 2003
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Fatty Liver
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Enzyme Inhibitors, Hepatoprotective, NF-kappaB Inhibitor
[+]

Curcumin inhibits prostate cancer tumors. Dec 01, 2009

Pubmed Data : Peptides. 2009 Dec;30(12):2357-64. Epub 2009 Sep 20. PMID: 19772879
Article Published Date : Dec 01, 2009
Study Type : Transgenic Animal Study
Additional Links
Substances : Curcumin
Diseases : Prostate Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]

Curcumin inhibits trinitrobenzene sulphonic acid-induced colitis in rats.Aug 01, 2006

Pubmed Data : Int Immunopharmacol. 2006 Aug;6(8):1233-42. Epub 2006 Apr 7. PMID: 16782535
Article Published Date : Aug 01, 2006
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Colitis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Prostaglandin PGE2 downregulation
[+]

Curcumin may have therapeutic value in colon cancer prevention.Oct 28, 1999

Pubmed Data : Oncogene. 1999 Oct 28;18(44):6013-20. PMID: 10557090
Article Published Date : Oct 28, 1999
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Colon Cancer
Pharmacological Actions : Antineoplastic Agents, Cyclooxygenase 2 Inhibitors, Enzyme Inhibitors, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Curcumin might be useful in the chemoprevention of colorectal cancer in individuals consuming an high-protein diet.Jul 31, 2015

Pubmed Data : Nutr Res. 2015 Aug ;35(8):726-35. Epub 2015 Jun 1. PMID: 26094212
Article Published Date : Jul 31, 2015
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Colorectal Cancer: Prevention , Gastrointestinal Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Curcumin potentiated significant increase in Nrf2 activation. It restored activity of phase-II antioxidant enzymes like GST, GR, NQO1, and tumour suppressor p53 level. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(4):e0124000. Epub 2015 Apr 10. PMID: 25860911
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Liver Cancer, Liver Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, MicroRNA modulator, Nrf2 activation, Tumor Suppressor Protein p53 Upregulation
[+]

Curcumin potentiates the antitumor effects of Bacillus Calmette-Guerin against bladder cancer.Dec 01, 2009

Pubmed Data : Cancer Res. 2009 Dec 1;69(23):8958-66. Epub 2009 Nov 10. PMID: 19903839
Article Published Date : Dec 01, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Bladder Cancer
Pharmacological Actions : Apoptotic, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Vascular Endothelial Growth Factor A Inhibitor
Additional Keywords : Drug Synergy
[+]

Curcumin prevents colon carcinogenesis. Apr 01, 1999

Pubmed Data : Carcinogenesis. 1999 Apr;20(4):641-4. PMID: 10223193
Article Published Date : Apr 01, 1999
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Colon Cancer, Colon Polyps
Pharmacological Actions : Anticarcinogenic Agents, Cyclooxygenase 2 Inhibitors, Enzyme Inhibitors, Nitric Oxide Inhibitor
[+]

Curcumin protects against necrotizing enterocolitis in neonatal rats.Feb 01, 2010

Pubmed Data : Zhongguo Dang Dai Er Ke Za Zhi. 2010 Feb;12(2):132-6. PMID: 20199731
Article Published Date : Feb 01, 2010
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Infant Infections, Necrotising enterocolitis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-10 downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Curcumin reduces oxidative and nitrative DNA damage associated with fluke infection.Oct 01, 2009

Pubmed Data : Mol Nutr Food Res. 2009 Oct;53(10):1316-28. PMID: 19753608
Article Published Date : Oct 01, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : DNA damage, Flukes, Oxidative Stress, Parasitic Diseases
Pharmacological Actions : Antimutagenic Agents, Antiparasitic Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Curcumin retards the growth of intestinal polyps in a mouse model of familial adenomatous polyposis.Feb 01, 2006

Pubmed Data : Eur J Cancer. 2006 Feb;42(3):415-21. Epub 2006 Jan 4. PMID: 16387490
Article Published Date : Feb 01, 2006
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Familial Adenomatous Polyposis, Intestinal Polyps
Pharmacological Actions : Chemopreventive, Cyclooxygenase 2 Inhibitors
[+]

Curcumin reverses neurochemical, histological and immuno-histochemical alterations in the model of global brain ischemia.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Tradit Complement Med. 2017 Jan ;7(1):14-23. Epub 2016 Feb 11. PMID: 28053883
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Brain Ischemia
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Curcumin works synergistically with paclitaxel to inhibit breast cancer cell metastasis to the lung in a mouse model. Oct 15, 2005

Pubmed Data : Clin Cancer Res. 2005 Oct 15;11(20):7490-8. PMID: 16243823
Article Published Date : Oct 15, 2005
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Breast Cancer, Breast Cancer: Lung Metastasis, Lung Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor, NF-kappaB Inhibitor
Additional Keywords : Drug: Paclitaxel, Drug-Plant-Vitamin Synergies
[+]

Cyanidin-3-O-glucoside exerts pulmonary protective effects on CLP-induced ALI rats. Jun 11, 2015

Pubmed Data : J Surg Res. 2015 Jun 12. Epub 2015 Jun 12. PMID: 26152793
Article Published Date : Jun 11, 2015
Study Type : Animal Study
Additional Links
Substances : Cyanidin 3-glucoside
Diseases : Lung Injury: Acute, Sepsis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Mitochondrial Superoxide Dismutase Upregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Daidzein attenuates abdominal aortic aneurysm through NF-κB, p38MAPK and TGF-β1 pathways.Jun 30, 2016

Pubmed Data : Mol Med Rep. 2016 Jul ;14(1):955-62. Epub 2016 May 18. PMID: 27222119
Article Published Date : Jun 30, 2016
Study Type : Animal Study
Additional Links
Substances : Daidzein, Isoflavones
Diseases : Aneurysm: Aortic
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Demethoxycurcumin may decrease COX-2 expression and improve endothelial function in hypertension.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2016 ;2016:9045736. Epub 2016 Dec 25. PMID: 28105253
Article Published Date : Dec 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Demethoxycurcumin
Diseases : Endothelial Dysfunction, Hypertension
Pharmacological Actions : Cyclooxygenase 2 Inhibitors
[+]

Dendrosomal curcumin has a chemoprotective effect on the breast cancer metastasis through suppression of NF-κB and its regulated gene products.Jul 04, 2015

Pubmed Data : Eur J Pharmacol. 2015 Jul 5 ;758:188-96. Epub 2015 Apr 8. PMID: 25863259
Article Published Date : Jul 04, 2015
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Breast Cancer, Breast Cancer: Metastatic
Pharmacological Actions : Anti-metastatic, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor, Vascular Endothelial Growth Factor Inhibitors
[+]

Dietary administration of garcinol effectively reduced the tumor size and incidence in the mouse colon.Aug 31, 2014

Pubmed Data : Mol Nutr Food Res. 2014 Sep ;58(9):1820-9. Epub 2014 Jul 1. PMID: 24981158
Article Published Date : Aug 31, 2014
Study Type : Animal Study
Additional Links
Substances : Garcinia indica
Diseases : Colon Cancer, Colon Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Chemopreventive, Cyclin D1 Down-Regulation, Cyclooxygenase 2 Inhibitors, Vascular Endothelial Growth Factor Inhibitors
[+]

Dietary astaxanthin inhibits colitis and colitis-associated colon carcinogenesis in mice.May 20, 2011

Pubmed Data : Chem Biol Interact. 2011 May 20. Epub 2011 May 20. PMID: 21621527
Article Published Date : May 20, 2011
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Colitis, Colon Cancer
Pharmacological Actions : Chemopreventive, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor
[+]

Dietary feeding of grape seed extract prevents intestinal tumorigenesis in mice.Jan 01, 2010

Pubmed Data : Neoplasia. 2010 Jan;12(1):95-102. PMID: 20072658
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract
Diseases : Intestinal Cancer, Intestinal Polyps
Pharmacological Actions : Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors
[+]

Dietary flaxseed may be chemopreventive for intestinal and colon tumor development in mice possibly by increasing omega -3 fatty acid levels, lignans, and decreasing COX-1 and COX-2 levels.Jan 01, 2009

Pubmed Data : Nutr Cancer. 2009;61(2):276-83. PMID: 19235044
Article Published Date : Jan 01, 2009
Study Type : Animal Study
Additional Links
Substances : Flaxseed, Lignans, Omega-3 Fatty Acids
Diseases : Colon Cancer, Intestinal Cancer
Pharmacological Actions : Anticarcinogenic Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors
[+]

Dietary flaxseed meal containing high levels of omega-3 fatty acids and lignans is effective in preventing colon tumor development when compared with dietary corn meal possibly by increasing omega-3 fatty acid levels and decreasing COX-1 and COX-2 levels.Jan 01, 2006

Pubmed Data : Nutr Cancer. 2006;54(2):216-22. PMID: 16898866
Article Published Date : Jan 01, 2006
Study Type : Animal Study
Additional Links
Substances : Flaxseed, Lignans, Omega-3 Fatty Acids
Diseases : Colon Cancer
Pharmacological Actions : Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
[+]

Dietary intake of pterostilbene, a constituent of blueberries, inhibits colon carcinogenesis in rats.Jul 01, 2010

Pubmed Data : Carcinogenesis. 2010 Jul;31(7):1272-8. Epub 2010 Jan 8. PMID: 20061362
Article Published Date : Jul 01, 2010
Study Type : Animal Study
Additional Links
Substances : Blueberry, Pterostilbene
Diseases : Colon Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors
Additional Keywords : Stilbenes
[+]

Dietary saturated fatty acids down-regulate cyclooxygenase-2 and tumor necrosis factor alfa and reverse fibrosis in alcohol-induced liver disease in the rat.Dec 01, 1997

Pubmed Data : Hepatology. 1997 Dec;26(6):1538-45. PMID: 9397995
Article Published Date : Dec 01, 1997
Study Type : Animal Study
Additional Links
Substances : Medium Chain Triglycerides, Palm Oil, Saturated fatty acids
Diseases : Alcoholic Liver Disease, Liver Fibrosis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Beneficial Saturated Fats, Disease Reversal
[+]

Dietary supplementation of resveratrol attenuates chronic colonic inflammation in mice.Jan 01, 2010

Pubmed Data : Asia Pac J Clin Nutr. 2010;19(1):142-50. PMID: 20132809
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol, Stilbenes
Diseases : Inflammation, Ulcerative Colitis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Nitric Oxide Inhibitor, P38 Mitogen-Activated Protein Kinase Modulator, Prostaglandin E Synthase-1 (PGES-1) Down-Regulation
[+]

Electroacupuncture was an effective analgesic and anti-inflammatory.Oct 23, 2016

Pubmed Data : Chin J Integr Med. 2016 Oct 24. Epub 2016 Aug 24. PMID: 27778263
Article Published Date : Oct 23, 2016
Study Type : Animal Study
Additional Links
Diseases : Neuropathic Pain
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
[+]

Ellagic acid exhibited a potent anti-inflammatory effect against carrageenan-induced inflammation.Mar 31, 2014

Pubmed Data : Int Immunopharmacol. 2014 Apr ;19(2):290-9. Epub 2014 Feb 15. PMID: 24534771
Article Published Date : Mar 31, 2014
Study Type : Animal Study
Additional Links
Substances : Ellagic Acid
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Malondialdehyde Down-regulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Essential oils extracted from Chamaecyparis obtusa may be considered an effective therapeutic agent for the treatment of inflammatory diseases.Mar 31, 2016

Pubmed Data : Mol Med Rep. 2016 Apr ;13(4):3335-41. Epub 2016 Feb 18. PMID: 26936418
Article Published Date : Mar 31, 2016
Study Type : Animal Study
Additional Links
Substances : Japanese cypress
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Essential Oils
[+]

Evening primrose oil ameliorates platelet aggregation and improves cardiac recovery in myocardial-infarct hypercholesterolemic rats.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Physiol Pathophysiol Pharmacol. 2014 ;6(1):23-36. Epub 2014 Mar 13. PMID: 24665356
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Evening Primrose Oil
Diseases : Myocardial Infarction
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Extracts of R. officinalis and rosmarinic acid through modulating neuro-inflammation might be potential candidates in treating neuropathic pain.Dec 21, 2016

Pubmed Data : Biomed Pharmacother. 2016 Dec 22 ;86:441-449. Epub 2016 Dec 22. PMID: 28012923
Article Published Date : Dec 21, 2016
Study Type : Animal Study
Additional Links
Substances : Rosemary, Rosmarinic acid
Diseases : Brain Inflammation , Neuropathic Pain
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation
Additional Keywords : Plant Extracts
[+]

Fermented brown rice and rice bran have a chemopreventive effect on inflammation-related colorectal carcinogenesis in mice. Jan 01, 2010

Pubmed Data : Oncol Rep. 2010 Jan;23(1):53-9. PMID: 19956864
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Brown Rice, Fermented Foods and Beverages, Rice Bran
Diseases : Colorectal Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
[+]

Fermented C. longa might be a useful material for preventing impairment of learning and memory.Jul 16, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2017 Jul 17 ;17(1):367. Epub 2017 Jul 17. PMID: 28716085
Article Published Date : Jul 16, 2017
Study Type : Animal Study
Additional Links
Substances : Turmeric: Fermented
Diseases : Cognitive Decline/Dysfunction, Memory Disorders
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Neuroprotective Agents, Nitric Oxide Inhibitor, Postaglandin PGE2 downregulation
[+]

Fisetin may be a potential agent in the treatment of osteoarthritis.Feb 13, 2017

Pubmed Data : Int Immunopharmacol. 2017 Feb 14 ;45:135-147. Epub 2017 Feb 14. PMID: 28213268
Article Published Date : Feb 13, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Fisetin
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Fucoidan exhibits a gastro-protective effect against aspirin-induced ulceration in rats.Jan 31, 2011

Pubmed Data : Int Immunopharmacol. 2011 Feb ;11(2):157-63. Epub 2010 Nov 26. PMID: 21084063
Article Published Date : Jan 31, 2011
Study Type : Animal Study
Additional Links
Substances : Fucoidan
Diseases : Aspirin-Induced Toxicity , Gastric Ulcer
Pharmacological Actions : Anti-Ulcer Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Epidermal growth factor receptor (EGFR) inhibitor
Problem Substances : Aspirin
Adverse Pharmacological Actions : Ulcerogenic
[+]

Fucoxanthin may have therapeutic potential as a treatment for patients with inflammatory diseases.Sep 28, 2015

Pubmed Data : J Biochem Mol Toxicol. 2015 Sep 29. Epub 2015 Sep 29. PMID: 26418808
Article Published Date : Sep 28, 2015
Study Type : Animal Study
Additional Links
Substances : Fucoxanthin
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Genipin inhibits allergic responses in ovalbumin-induced asthmatic mice.Nov 30, 2017

Pubmed Data : Int Immunopharmacol. 2017 Dec ;53:49-55. Epub 2017 Oct 15. PMID: 29035815
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Genipin
Diseases : Asthma
Pharmacological Actions : Anti-Asthmatic Agents, Cyclooxygenase 2 Inhibitors, interleukin-13 down-regulation, Interleukin-5 downregulation, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Geniposide and genipin have a healthy promotion to eradicate H. pylori infections.Nov 30, 2017

Pubmed Data : J Food Sci. 2017 Dec ;82(12):3021-3028. Epub 2017 Nov 14. PMID: 29135040
Article Published Date : Nov 30, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Genipin
Diseases : Helicobacter Pylori Infection
Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interferon Gamma Reducer, Interleukin-1 beta downregulation
[+]

Geraniol attenuates 4NQO-induced tongue carcinogenesis through downregulating the activation of NF-κB in rats.Sep 30, 2017

Pubmed Data : Mol Cell Biochem. 2017 Oct ;434(1-2):7-15. Epub 2017 Apr 10. PMID: 28397014
Article Published Date : Sep 30, 2017
Study Type : Animal Study
Additional Links
Substances : Geraniol
Diseases : Tongue Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Geraniol could be a powerful treatment of intestinal inflammation and dysbiosis.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2016 ;7:38. Epub 2016 Mar 3. PMID: 26973525
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Geraniol
Diseases : Colitis, Dysbiosis, Gastrointestinal Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
[+]

Germinated brown rice can be a promising dietary supplement in prevention of colon cancer.Mar 25, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr J. 2010 Mar 26 ;9:16. Epub 2010 Mar 26. PMID: 20346115
Article Published Date : Mar 25, 2010
Study Type : Animal Study
Additional Links
Substances : Brown Rice
Diseases : Colon Cancer
Pharmacological Actions : Anticarcinogenic Agents, Cyclooxygenase 2 Inhibitors
[+]

Ginger inhibits micoglial cell activiation associated with brain inflammation. Jun 01, 2009

Pubmed Data : Food Chem Toxicol. 2009 Jun;47(6):1190-7. Epub 2009 Feb 20. PMID: 19233241
Article Published Date : Jun 01, 2009
Study Type : Animal Study
Additional Links
Substances : Ginger
Diseases : Brain: Microglial Activation, Brain Inflammation , Inflammation, Lipopolysaccharide-Induced Toxicity, Neurodegenerative Diseases
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Prostaglandin Antagonists
[+]

Gingerol could protect against experimental liver fibrosis in rats.Jan 25, 2016

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2016 Jan 26. Epub 2016 Jan 26. PMID: 26809353
Article Published Date : Jan 25, 2016
Study Type : Animal Study
Additional Links
Substances : Gingerol
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Ginkgetin may be beneficial against chronic skin inflammatory disorders like atopic dermatitis.Apr 30, 2006

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2006 May ;29(5):1046-9. PMID: 16651744
Article Published Date : Apr 30, 2006
Study Type : Animal Study
Additional Links
Substances : Ginkgo biloba
Diseases : Atopic Dermatitis, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation
[+]

Ginkgo biloba extract anti-inflammatory properties and ameliorates colitis in mice. Sep 01, 2008

Pubmed Data : Carcinogenesis. 2008 Sep;29(9):1799-806. Epub 2008 Jun 20. PMID: 18567620
Article Published Date : Sep 01, 2008
Study Type : Animal Study
Additional Links
Substances : Ginkgo biloba
Diseases : Colitis, Inflammation
Pharmacological Actions : Antioxidants, Apoptotic, Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts
[+]

Ginkgo biloba extract protects against aging-associated mitochondrial dysfunction in platelets and hippocampi of mice.Jan 01, 2010

Pubmed Data : Platelets. 2010;21(5):373-9. PMID: 20459350
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Ginkgo biloba
Diseases : Aging, Aging: Brain , Mitochondrial Dysfunction
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

Ginsenoside Rd inhibits the expressions of iNOS and COX-2 by suppressing NF-κB.Feb 28, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Ginseng Res. 2013 Mar ;37(1):54-63. PMID: 23717157
Article Published Date : Feb 28, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Ginsenoside Rh3 metabolized from ginsenoside Rg5 may improve chronic dermatitis or psoriasis.Jul 31, 2006

Pubmed Data : Arch Pharm Res. 2006 Aug ;29(8):685-90. PMID: 16964764
Article Published Date : Jul 31, 2006
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Dermatitis, Psoriasis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Ginsenosides from the leaves of Panax quinquefolius ameliorated acetaminophen-induced hepatotoxicity in mice.May 09, 2017

Pubmed Data : J Agric Food Chem. 2017 May 10 ;65(18):3684-3692. Epub 2017 Apr 25. PMID: 28429935
Article Published Date : May 09, 2017
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective, Malondialdehyde Down-regulation
Problem Substances : Acetaminophen, Paracetamol
[+]

Grape juice concentrate is able to exert some chemopreventive activity on rat colon carcinogenesis.Oct 31, 2015

Pubmed Data : Environ Toxicol Pharmacol. 2015 Nov ;40(3):870-5. Epub 2015 Sep 28. PMID: 26492449
Article Published Date : Oct 31, 2015
Study Type : Animal Study
Additional Links
Substances : Grape
Diseases : Colon Cancer
Pharmacological Actions : Chemopreventive, Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts
[+]

Grape stem extract reduces UVB-induced oxidative damage and hence can play a protective role in skin photo-damage.Jul 31, 2017

Pubmed Data : J Photochem Photobiol B. 2017 Aug ;173:551-559. Epub 2017 Jun 29. PMID: 28697472
Article Published Date : Jul 31, 2017
Study Type : Animal Study
Additional Links
Substances : Grape
Diseases : Ultraviolet Radiation Induced Damage
Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 inducer, Malondialdehyde Down-regulation, Nrf2 activation, Photoprotective
Additional Keywords : Plant Extracts
[+]

Graviola possesses analgesic effects through interaction with opioidergic pathway and anti-inflammatory properties through inhibition of chemical mediators of inflammation.Nov 30, 2014

Pubmed Data : J Med Food. 2014 Dec ;17(12):1375-82. PMID: 25133801
Article Published Date : Nov 30, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Graviola
Diseases : Arthritis, Rheumatism
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
Additional Keywords : Natural Substances Versus Drugs
Problem Substances : Carrageenan
[+]

Hesperidin may be a promising modulator in preventing renal cancer.Aug 10, 2018

Pubmed Data : Environ Toxicol. 2018 Aug 11. Epub 2018 Aug 11. PMID: 30098279
Article Published Date : Aug 10, 2018
Study Type : Animal Study
Additional Links
Substances : Hesperidin
Diseases : Liver Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation , Vascular Endothelial Growth Factor Regulator
[+]

Hesperidin protects against stress induced gastric ulcer.Jun 22, 2018

Pubmed Data : Chem Biol Interact. 2018 Jun 23 ;291:153-161. Epub 2018 Jun 23. PMID: 29944876
Article Published Date : Jun 22, 2018
Study Type : Animal Study
Additional Links
Substances : Hesperidin
Diseases : Diabetic Ulcer, Gastric Ulcer
Pharmacological Actions : Anti-Inflammatory Agents, Anti-Ulcer Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Nrf2 activation
Additional Keywords : Natural Substances Versus Drugs
[+]

Hispolon could be useful in the treatment of breast cancers or other gynecologic diseases.Dec 31, 2016

Pubmed Data : Int J Med Mushrooms. 2017 ;19(3):233-242. PMID: 28605338
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Medicinal Mushrooms
Diseases : Breast Cancer
Pharmacological Actions : Aromatase Inhibitors, Cyclooxygenase 2 Inhibitors
[+]

Honey protects against cisplatin-induced hepatic and renal toxicity.Jun 12, 2018

Pubmed Data : Food Funct. 2018 Jun 13. Epub 2018 Jun 13. PMID: 29897076
Article Published Date : Jun 12, 2018
Study Type : Animal Study
Additional Links
Substances : Honey, Manuka Honey
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Chemoprotective Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective, NF-kappaB Inhibitor, Renoprotective
[+]

Honokiol alleviates the degeneration of intervertebral disc.May 19, 2018

Pubmed Data : Free Radic Biol Med. 2018 May 20 ;120:368-379. Epub 2018 Apr 9. PMID: 29649568
Article Published Date : May 19, 2018
Study Type : Animal Study
Additional Links
Substances : Honokiol
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, NF-kappaB Inhibitor
[+]

Honokiol has the ability to inhibit UVB-induced immunosuppression in preclinical model.May 09, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 May 10 ;7(1):1657. Epub 2017 May 10. PMID: 28490739
Article Published Date : May 09, 2017
Study Type : Animal Study
Additional Links
Substances : Honokiol
Diseases : Skin Cancer: Prevention, Ultraviolet Radiation Induced Damage
Pharmacological Actions : Chemopreventive, Cyclooxygenase 2 Inhibitors, Immunomodulatory, Postaglandin PGE2 downregulation
[+]

Hops (H. lupulus) has anti-inflammatory activity in a mouse model of athritis. Jul 16, 1996

Pubmed Data : Biochem Biophys Res Commun. 1996 Jul 16;224(2):358-61. PMID: 16534727
Article Published Date : Jul 16, 1996
Study Type : Animal Study
Additional Links
Substances : Hops
Diseases : Arthritis, Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation
Additional Keywords : Plant Extracts
[+]

Hydrogen rich water pre-treatment alleviated the aspirin-induced gastric lesions.Feb 13, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2014 Feb 14 ;20(6):1614-22. PMID: 24587639
Article Published Date : Feb 13, 2014
Study Type : Animal Study
Additional Links
Substances : Hydrogen Water
Diseases : Aspirin-Induced Toxicity , Gastrointestinal Inflammation, Oxidative Stress
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Gastroprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Aspirin
[+]

Intragastric administration of curcumin inhibited the experimentally induced murine colitis.Feb 28, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cancer Prev. 2018 Mar ;23(1):18-24. Epub 2018 Mar 30. PMID: 29629345
Article Published Date : Feb 28, 2018
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, STAT3 Inhibitor
[+]

Isoliquiritigenin has a protective effect against carbon tetrachloride-induced liver damage.Jan 04, 2015

Pubmed Data : Chem Biol Interact. 2015 Jan 5 ;225:13-20. Epub 2014 Nov 6. PMID: 25450236
Article Published Date : Jan 04, 2015
Study Type : Animal Study
Additional Links
Substances : Isoliquiritigenin
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Enzyme Inhibitors, Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Isoquercitrin may be effective in the prevention of acute colitis.Nov 30, 2016

Pubmed Data : Pharmacol Rep. 2016 Dec ;68(6):1197-1204. Epub 2016 Sep 19. PMID: 27657482
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Substances : Isoquercitrin
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
[+]

Korean Red Ginseng extracts exhibited anti-inflammatory effects by ameliorating the symptoms of gastric ulcer in a gastritis mouse model.Sep 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Ginseng Res. 2016 Oct ;40(4):437-444. Epub 2016 Aug 24. PMID: 27746698
Article Published Date : Sep 30, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginseng (Korean)
Diseases : Gastric Ulcer, Gastritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Gastrointestinal Agents, Gastroprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Lactobacillus fermentum HY01 had significant preventive effects in dextran sulfate sodium induced-colitis.May 24, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2017 May 25 ;9(6). Epub 2017 May 25. PMID: 28587089
Article Published Date : May 24, 2017
Study Type : Animal Study
Additional Links
Substances : Lactobacillus fermentum
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interferon Gamma Reducer, Interleukin-12 downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Lactobacillus fermentum IM12 attenuates inflammation in mice.May 29, 2017

Pubmed Data : Benef Microbes. 2017 May 30 ;8(3):407-419. Epub 2017 May 15. PMID: 28504577
Article Published Date : May 29, 2017
Study Type : Animal Study
Additional Links
Substances : Lactobacillus fermentum
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, NF-kappaB Inhibitor
[+]

Lactobacillus paracasei GMNL-32 exerts a therapeutic effect on cardiac abnormalities in mice.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(9):e0185098. Epub 2017 Sep 21. PMID: 28934296
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Lactobacillus paracasei
Diseases : Cardiovascular Disease, Lupus Erythematosus: Systemic
Pharmacological Actions : Anti-Apoptotic, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]

LED therapy provides an analgesic effect and modifies the expression of COX-2, PGE2, and proinflammatory cytokines in incised skin.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pain Res Manag. 2017 ;2017:4792489. Epub 2017 Apr 2. PMID: 28469528
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Diseases : Wound Healing
Therapeutic Actions : Light-Emitting Diodes (LEDs) Therapy
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation
[+]

Lion's mane has antitumor effects in tumor-bearing mice.Sep 28, 2011

Pubmed Data : J Agric Food Chem. 2011 Sep 28 ;59(18):9861-9. Epub 2011 Aug 25. PMID: 21846141
Article Published Date : Sep 28, 2011
Study Type : Animal Study
Additional Links
Substances : Lion's Mane (Hericium Erinaceus)
Diseases : Colon Cancer, Low Immune Function: Natural Killer Cells, Tumors
Pharmacological Actions : 5-Lipoxygenase Inhibitor, Anti-Angiogenic, Antineoplastic Agents, Cyclooxygenase 2 Inhibitors, Vascular Endothelial Growth Factor Inhibitors
[+]

Lupeol acetate significantly improves the symptoms of RA by down-regulating expressions of inflammatory cytokines and osteoclastogenesis.Mar 31, 2016

Pubmed Data : Biomed Pharmacother. 2016 Apr ;79:231-40. Epub 2016 Mar 11. PMID: 27044833
Article Published Date : Mar 31, 2016
Study Type : Animal Study
Additional Links
Substances : Lupeol
Diseases : Arthritis, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Dose Response
[+]

L‑carnitine ameliorated liver inflammation and serum pro‑inflammatory markers in cancer cachexia.Dec 03, 2015

Pubmed Data : Mol Med Rep. 2015 Dec 4. Epub 2015 Dec 4. PMID: 26647854
Article Published Date : Dec 03, 2015
Study Type : Animal Study
Additional Links
Substances : L-Carnitine
Diseases : Cachexia: Cancer, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

M. oleifera containing Vicenin-2 active compound may accelerate wound healing in hyperglycemic conditions.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2016 ;10:1715-30. Epub 2016 May 24. PMID: 27307703
Article Published Date : Dec 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Moringa oleifera
Diseases : Diabetic Complications, Wound Healing: Delayed
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Mangiferin is potent anti-inflammatory compound that reduces inflammation.Feb 19, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Feb 20 ;7:42683. Epub 2017 Feb 20. PMID: 28218280
Article Published Date : Feb 19, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Mangiferin
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Melatonin and pycnogenol have a therapeutic role in the treatment fo endothelial dysfunction.Aug 01, 2003

Pubmed Data : Int J Mol Med. 2003 Aug;12(2):269-73. PMID: 20421515
Article Published Date : Aug 01, 2003
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Melatonin
Diseases : Endothelial Dysfunction, Hypertension
Pharmacological Actions : Antihypertensive Agents, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]

Melatonin causes regression and atrophy of the endometriotic lesions in rats.Apr 01, 2008

Pubmed Data : Fertil Steril. 2008 Apr;89(4):934-42. Epub 2007 Jun 19. PMID: 17582405
Article Published Date : Apr 01, 2008
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Endometriosis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors
[+]

Morinda citrifolia leaf was more effective than the erlotinib in suppressing lung adenocarcinoma in mice. Jan 13, 2016

Pubmed Data : Food Funct. 2016 Jan 14. Epub 2016 Jan 14. PMID: 26765787
Article Published Date : Jan 13, 2016
Study Type : Animal Study
Additional Links
Substances : Noni, Noni leaf extract
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer
Pharmacological Actions : Antiproliferative , Cyclooxygenase 2 Inhibitors, Epidermal growth factor receptor (EGFR) inhibitor, Immunomodulatory
Additional Keywords : Dose Response, Superiority of Natural Substances versus Drugs
[+]

Mulberry fruit suppressed the development of intestinal inflammation and tumorgenesis both in vitro and in vivo.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2015 ;5:17348. Epub 2015 Nov 30. PMID: 26615818
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Mulberry
Diseases : Colitis, Colorectal Cancer: Prevention , Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Myricetin has protective cardiovascular effects against ischemia/reperfusion-induced myocardial injury.Aug 01, 2016

Pubmed Data : Cardiovasc Toxicol. 2016 Aug 2. Epub 2016 Aug 2. PMID: 27484498
Article Published Date : Aug 01, 2016
Study Type : Animal Study
Additional Links
Substances : Myricetin
Diseases : Myocardial Ischemia
Pharmacological Actions : Antioxidants, Cardioprotective, Cyclooxygenase 2 Inhibitors, Malondialdehyde Down-regulation
[+]

Nano-gold displayed anti-inflammatory properties. Mar 18, 2018

Pubmed Data : Artif Cells Nanomed Biotechnol. 2018 Mar 19:1-10. Epub 2018 Mar 19. PMID: 29553845
Article Published Date : Mar 18, 2018
Study Type : Animal Study
Additional Links
Substances : Gold (nanoparticles)
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor
[+]

Naringenin ameliorates learning and memory impairment following systemic lipopolysaccharide challenge.Mar 04, 2018

Pubmed Data : Eur J Pharmacol. 2018 Mar 5. Epub 2018 Mar 5. PMID: 29518393
Article Published Date : Mar 04, 2018
Study Type : Animal Study
Additional Links
Substances : Naringenin
Diseases : Lipopolysaccharide-Induced Toxicity, Memory Disorders
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Neuroprotective Agents, NF-kappaB Inhibitor, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Anti-Inflammatory Agents, Lipopolysaccharide-Induced Toxicity, Memory Disorders, Naringenin
[+]

Naringenin suppresses the development of precancerous lesions via controlling hyperproliferation and inflammation in the colon.Jan 17, 2018

Pubmed Data : Environ Toxicol. 2018 Jan 18. Epub 2018 Jan 18. PMID: 29345053
Article Published Date : Jan 17, 2018
Study Type : Animal Study
Additional Links
Substances : Naringenin
Diseases : Colon Cancer: Prevention
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
Additional Keywords : Anti-Inflammatory Agents, Anticarcinogenic Agents, Colon Cancer: Prevention, Naringenin
[+]

Nexrutine could be useful candidate agent for colon cancer chemoprevention and treatment.Jul 31, 2016

Pubmed Data : Mol Carcinog. 2016 Aug ;55(8):1262-74. Epub 2015 Aug 10. PMID: 26259065
Article Published Date : Jul 31, 2016
Study Type : Animal Study
Additional Links
Substances : Nexrutine (Phellodendrom)
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemopreventive, Cyclooxygenase 2 Inhibitors
[+]

Nobiletin restored intestinal barrier function, which had been damaged after TNBS administration, through the inhibition of the Akt-NF-κB-MLCK pathway.Apr 30, 2015

Pubmed Data : Mol Nutr Food Res. 2015 May ;59(5):829-42. Epub 2015 Mar 16. PMID: 25655748
Article Published Date : Apr 30, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Citrus Peel , Nobiletin
Diseases : Colitis, Inflammation, Intestinal Permeability
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
[+]

Noni, and its major bioactive component damnacanthal, exhibits anti-inflammatory properties. Nov 01, 2011

Pubmed Data : Inflamm Allergy Drug Targets. 2011 Nov 1. Epub 2011 Nov 1. PMID: 21999179
Article Published Date : Nov 01, 2011
Study Type : Animal Study
Additional Links
Substances : Damnacanthal, Noni
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Nitric Oxide Inhibitor
[+]

Nutmeg oil alleviates chronic inflammatory pain through inhibition of COX-2 expression.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Nutr Res. 2016 ;60:30849. Epub 2016 Apr 26. PMID: 27121041
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Nutmeg
Diseases : Allodynia, Chronic Pain, Inflammation
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
Additional Keywords : Superiority of Natural Substances versus Drugs
Problem Substances : Diclofenac
[+]

Oligonol ameliorates carbon tetrachloride induced liver injury in rats. Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2016 ;2016:3935841. Epub 2015 Dec 21. PMID: 26798422
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Lychee
Diseases : Chemically-Induced Liver Damage, Lipid Peroxidation
Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, Hepatoprotective, Interleukin-1 beta downregulation, Malondialdehyde Down-regulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Oligonol is effective in protecting against DSS-induced mouse colitis and colon carcinogenesis.Jul 09, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxid Redox Signal. 2013 Jul 10 ;19(2):102-14. Epub 2013 May 15. PMID: 23394584
Article Published Date : Jul 09, 2013
Study Type : Animal Study
Additional Links
Substances : Lychee
Diseases : Colitis, Colon Cancer, Inflammation, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Anticarcinogenic Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Colitis, COLON CANCER, Inflammation, Lipid Peroxidation, Lychee, oxidative stress
[+]

Olive leaf methanolic extract prevents ethanol-induced gastritis.Jun 30, 2017

Pubmed Data : Biomed Pharmacother. 2017 Jul ;91:338-349. Epub 2017 May 2. PMID: 28463797
Article Published Date : Jun 30, 2017
Study Type : Animal Study
Additional Links
Substances : Olive leaf extract
Diseases : Alcohol Toxicity , Gastritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Gastroprotective, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Oral administration of black ginger extract significantly prevents UVB-induced photoaging in hairless mice.Sep 30, 2014

Pubmed Data : Photodermatol Photoimmunol Photomed. 2014 Oct ;30(5):237-45. Epub 2014 Jan 9. PMID: 24313661
Article Published Date : Sep 30, 2014
Study Type : Animal Study
Additional Links
Substances : Kaempferia parviflora
Diseases : Aging Skin, Ultraviolet Radiation Induced Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Catalase Up-Regulation, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor, Photoprotective
Additional Keywords : Plant Extracts
[+]

Oral cannabidiol has a beneficial action on two symptoms of established inflammation: edema and hyperalgesia.Feb 29, 2004

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2004 Mar ;369(3):294-9. Epub 2004 Feb 12. PMID: 14963641
Article Published Date : Feb 29, 2004
Study Type : Animal Study
Additional Links
Substances : Cannabidiol, Cannabis
Diseases : Hyperalgesia, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation
[+]

Oral concentrated grape juice suppresses expression of NF-kappa B, TNF-α and iNOS in experimentally induced colorectal carcinogenesis.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(3):947-52. PMID: 25735387
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Grape
Diseases : Colorectal Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Fruit Juice, Phytotherapy, Plant Extracts
[+]

Oral curcumin may have chemopreventive properties against colorectal cancer. Feb 01, 2001

Pubmed Data : Cancer Res. 2001 Feb 1;61(3):1058-64. PMID: 11221833
Article Published Date : Feb 01, 2001
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Colorectal Cancer
Pharmacological Actions : Anticarcinogenic Agents, Cyclooxygenase 2 Inhibitors
[+]

Oral feeding of pomegranate fruit extract inhibits early biomarkers of UVB radiation-induced carcinogenesis. Nov 01, 2010

Pubmed Data : Photochem Photobiol. 2010 Nov-Dec;86(6):1318-26. Epub 2010 Oct 14. PMID: 20946358
Article Published Date : Nov 01, 2010
Study Type : Animal Study
Additional Links
Substances : Pomegranate
Diseases : Lipid Peroxidation, Skin Cancer: Prevention
Therapeutic Actions : Sunlight exposure
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts
[+]

Oral tangeretin treatment effectively reduced the tumor cell proliferation markers and suppressed metastasis. Oct 31, 2014

Pubmed Data : J Nutr Biochem. 2014 Nov ;25(11):1140-53. Epub 2014 Aug 1. PMID: 25151216
Article Published Date : Oct 31, 2014
Study Type : Animal Study
Additional Links
Substances : Tangeretin
Diseases : Breast Cancer, Breast Cancer: Metastatic
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Chemotherapeutic, Cyclooxygenase 2 Inhibitors, Nitric Oxide Inhibitor
[+]

Palmitoylethanolamide improves colon inflammation.Jul 31, 2014

Pubmed Data : Gut. 2014 Aug ;63(8):1300-12. Epub 2013 Sep 30. PMID: 24082036
Article Published Date : Jul 31, 2014
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Colitis, Ulcerative Colitis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Palmitoylethanolamide protects mice against 6-OHDA-induced neurotoxicity and endoplasmic reticulum stressOct 31, 2016

Pubmed Data : Pharmacol Res. 2016 Nov ;113(Pt A):276-289. Epub 2016 Sep 8. PMID: 27616549
Article Published Date : Oct 31, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Neurodegenerative Diseases, Oxidative Stress, Parkinson's Disease
Pharmacological Actions : Anti-Apoptotic, Cyclooxygenase 2 Inhibitors, Neuroprotective Agents, Nitric Oxide Inhibitor, Superoxide Dismutase Up-regulation
[+]

Panax ginseng anthocyanins pre-administration can significantly prevent cisplatin-induced nephrotoxicity.Jul 20, 2017

Pubmed Data : Phytother Res. 2017 Jul 21. Epub 2017 Jul 21. PMID: 28731262
Article Published Date : Jul 20, 2017
Study Type : Animal Study
Additional Links
Substances : Anthocyanins, Panax Ginseng
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Chemoprotective Agents, Cyclooxygenase 2 Inhibitors, Nitric Oxide Inhibitor
Additional Keywords : Anthocyanins, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Cyclooxygenase 2 Inhibitors, Nitric Oxide Inhibitor, Panax Ginseng
[+]

Perilla frutescens and rosmarinic acid may play a role in ameliorating allergy diseases.Jan 01, 2011

Pubmed Data : Exp Biol Med (Maywood). 2011 Jan;236(1):99-106. PMID: 21239739
Article Published Date : Jan 01, 2011
Study Type : Animal Study
Additional Links
Substances : Perilla , Rosmarinic acid
Diseases : Allergic Rhinitis, Allergic Rhinoconjunctivitis
Pharmacological Actions : Anti-Allergic Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor
Additional Keywords : Plant Extracts
[+]

Phloretin inhibits phorbol ester-induced tumor promotion and expression of cyclooxygenase-2 in mouse skin.Feb 29, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Med Food. 2012 Mar ;15(3):253-7. Epub 2011 Dec 19. PMID: 22181070
Article Published Date : Feb 29, 2012
Study Type : Animal Study
Additional Links
Substances : Phloretin
Diseases : Skin Cancer
Pharmacological Actions : Anticarcinogenic Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
Additional Keywords : Anticarcinogenic Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Phloretin, skin cancer
[+]

Piceatannol may be a potential therapeutic agent for osteoarthritis.Nov 14, 2017

Pubmed Data : Food Funct. 2017 Nov 15 ;8(11):3926-3937. PMID: 28933476
Article Published Date : Nov 14, 2017
Study Type : Animal Study
Additional Links
Substances : Piceatannol
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 inducer, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nrf2 activation, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Pine need extract is anti-inflammatory and has a protective effect on cholesteorl oxidation. Jan 01, 2008

Pubmed Data : Food Chem Toxicol. 2008 Jan;46(1):175-85. Epub 2007 Jul 28. PMID: 17804140
Article Published Date : Jan 01, 2008
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Pine Needle, Polyphenols
Diseases : Cholesterol: Oxidation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, Enzyme Inhibitors
[+]

Plant-derived oil rich in ALA could ameliorate the inflammatory damage in colitis.Aug 13, 2015

Pubmed Data : J Nutr Biochem. 2015 Aug 14. Epub 2015 Aug 14. PMID: 26350254
Article Published Date : Aug 13, 2015
Study Type : Animal Study
Additional Links
Substances : ALA (Alpha-Linolenic Acid)
Diseases : Colitis, Inflammatory Bowel Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Polyphenol-rich extract of Ocimum gratissimum leaves ameliorates colitis.Jun 30, 2018

Pubmed Data : Biomed Pharmacother. 2018 Jul ;103:812-822. Epub 2018 Apr 24. PMID: 29684860
Article Published Date : Jun 30, 2018
Study Type : Animal Study
Additional Links
Substances : African Basil
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Gastroprotective, Interleukin-10 upregulation, Interleukin-4 upregulation, Interleukin-6 Downregulation
[+]

Pomegranate by-products could be used in colorectal cancer chemoprevention.Sep 24, 2017

Pubmed Data : Mol Nutr Food Res. 2017 Sep 25. Epub 2017 Sep 25. PMID: 28948694
Article Published Date : Sep 24, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Pomegranate
Diseases : Colorectal Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, Chemopreventive, Cyclooxygenase 2 Inhibitors
[+]

Pomegranate extract is abundant in hydrolysable tannins that display multiple anti-acne capacities.Jan 11, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2017 Jan 12 ;18(1). Epub 2017 Jan 12. PMID: 28085116
Article Published Date : Jan 11, 2017
Study Type : Animal Study
Additional Links
Substances : Pomegranate
Diseases : Acne
Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation
Additional Keywords : Plant Extracts
[+]

Protective effects of orange peel aqueous extract and hesperidin on oxidative stress and peptic ulcer induced by alcohol.Aug 13, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Lipids Health Dis. 2017 Aug 14 ;16(1):152. Epub 2017 Aug 14. PMID: 28806973
Article Published Date : Aug 13, 2017
Study Type : Animal Study
Additional Links
Substances : Citrus Peel , Hesperidin, Orange
Diseases : Alcohol Toxicity , Gastric Ulcer, Oxidative Stress
Pharmacological Actions : Anti-Ulcer Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Drug: Omeprazole, Plant Extracts
[+]

Punicalagin inhibits lipopolysaccharide induced memory impairment via anti-inflammatory and anti-amylogenic mechanisms.Jan 25, 2017

Pubmed Data : Neuropharmacology. 2017 Jan 26 ;117:21-32. Epub 2017 Jan 26. PMID: 28132781
Article Published Date : Jan 25, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Brain Inflammation , Lipopolysaccharide-Induced Toxicity, Memory Disorders
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Punicalagin protected rat livers against cyclophosphamide toxicity.Jun 30, 2016

Pubmed Data : Environ Toxicol Pharmacol. 2016 Jul ;45:158-62. Epub 2016 Aug 1. PMID: 27310207
Article Published Date : Jun 30, 2016
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Hepatoprotective
[+]

Purple sweet potato induces antioxidant defense via the Nrf2 pathway and reduces inflammation via NF-κB inhibition in DMN-induced liver injury.Dec 31, 2010

Pubmed Data : Food Chem Toxicol. 2011 Jan ;49(1):93-9. Epub 2010 Oct 8. PMID: 20934476
Article Published Date : Dec 31, 2010
Study Type : Animal Study
Additional Links
Substances : Anthocyanins, Sweet Potato: Purple
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective, NF-kappaB Inhibitor, Nrf2 activation
[+]

Purple sweet potato may be useful for mitigating inflammatory brain diseases by the inhibition of proinflammatory molecule production.Jan 31, 2010

Pubmed Data : Neurochem Int. 2010 Feb ;56(3):424-30. Epub 2009 Nov 24. PMID: 19941923
Article Published Date : Jan 31, 2010
Study Type : Animal Study
Additional Links
Substances : Sweet Potato: Purple
Diseases : Brain Inflammation , Lipopolysaccharide-Induced Toxicity, Memory Disorders
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Quercetin application attenuated mucosal damage from ischemia reperfusion injury by inhibiting neutrophil infiltration.Aug 27, 2017

Pubmed Data : Biomed Pharmacother. 2017 Aug 28 ;95:346-354. Epub 2017 Aug 28. PMID: 28858733
Article Published Date : Aug 27, 2017
Study Type : Animal Study
Additional Links
Substances : Quercetin
Diseases : Intestinal Ischemia
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Gastroprotective
[+]

Quercetin can efficiently prevent stress induced neurological complications by rescuing brain from oxidative and inflammatory stress.Mar 14, 2017

Pubmed Data : Physiol Behav. 2017 Mar 15 ;171:69-78. Epub 2017 Jan 7. PMID: 28069457
Article Published Date : Mar 14, 2017
Study Type : Animal Study
Additional Links
Substances : Nettle, Quercetin
Diseases : Brain: Oxidative Stress, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Anti-Inflammatory Agents, Antioxidants, Brain: Oxidative Stress, nettle, oxidative stress, QUERCETIN
[+]

Quercitrin attenuates acetaminophen induced liver damage by the activation of defensive genes and the inhibition of pro-inflammatory genes.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2016 ;8(7). Epub 2016 Jul 15. PMID: 27428996
Article Published Date : Dec 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Toona sinensis
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, NF-E2-Related Factor-2 (Nrf2) Modulator
Problem Substances : Acetaminophen, Paracetamol
[+]

Red light modulates ultraviolet-induced gene expression in the epidermis of hairless mice.Sep 30, 2015

Pubmed Data : Photomed Laser Surg. 2015 Oct ;33(10):498-503. Epub 2015 Sep 23. PMID: 26398729
Article Published Date : Sep 30, 2015
Study Type : Animal Study
Additional Links
Diseases : Ultraviolet Radiation Induced Damage
Therapeutic Actions : Light-Emitting Diodes (LEDs) Therapy
Pharmacological Actions : Cyclooxygenase 2 Inhibitors
Additional Keywords : Gene Expression Regulation
[+]

Red wine and black tea and polyphenolic extracts modulate COX-2, iNOS and GSH-related gene expression in tumors, suggesting also a possible chemotherapeutic activity of these compounds.May 31, 2002

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Nutr. 2002 Jun ;132(6):1376-9. PMID: 12042461
Article Published Date : May 31, 2002
Study Type : Animal Study
Additional Links
Substances : Black Tea, Polyphenols, Red Wine
Diseases : Colon Cancer, Colon Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Chemotherapeutic, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors, Enzyme Inhibitors, Nitric Oxide Inhibitor
Additional Keywords : Gene Expression Regulation
[+]

Resveratrol has anti-inflammatory and chemopreventive properties in an animal model of liver cancer. Jun 01, 2010

Pubmed Data : Pharm Res. 2010 Jun;27(6):1080-91. Epub 2010 Apr 20. PMID: 20405173
Article Published Date : Jun 01, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Inflammation, Liver Cancer
Pharmacological Actions : Anticarcinogenic Agents, Cyclooxygenase 2 Inhibitors, Heat Shock Protein Inducer, NF-kappaB Inhibitor
Additional Keywords : Stilbenes
[+]

Resveratrol has anti-inflammatory and neuroprotective properties in experimental diabetic neuropathy.Apr 02, 2010

Pubmed Data : Biochem Biophys Res Commun. 2010 Apr 2;394(2):360-5. Epub 2010 Mar 6. PMID: 20211601
Article Published Date : Apr 02, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol, Stilbenes
Diseases : Diabetic Neuropathy, Oxidative Stress
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Neuroprotective Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Resveratrol inhibits proinflammatory cytokine (IL-8) production in monocytic cells. Jan 01, 2009

Pubmed Data : Am J Chin Med. 2009;37(6):1203-14. PMID: 19938227
Article Published Date : Jan 01, 2009
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Inflammation
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Immunomodulatory, Interleukin-8 downregulation, NF-kappaB Inhibitor
[+]

Resveratrol may protect against colitis through up-regulation of SIRT1 in immune cells in the colon.Mar 01, 2010

Pubmed Data : J Pharmacol Exp Ther. 2010 Mar;332(3):829-39. Epub 2009 Nov 25. PMID: 19940103
Article Published Date : Mar 01, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol, Stilbenes
Diseases : Colitis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, SIRT1 Activator
[+]

Rosmarinic acid could have the potential to prevent some psychological and biochemical alterations of brain tissue found in a rat model of Alzheimer's disease.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Folia Histochem Cytobiol. 2015 ;53(4):283-93. Epub 2015 Dec 30. PMID: 26714446
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Rosemaric Acid
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Neuroprotective Agents
Additional Keywords : Ovariectomy-Induced Changes
[+]

Rosmarinic acid has an ameliorative effect on colonic inflammation and thus a potential therapeutic role in colitis.Apr 05, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Apr 6 ;7:46252. Epub 2017 Apr 6. PMID: 28383063
Article Published Date : Apr 05, 2017
Study Type : Animal Study
Additional Links
Substances : Rosmarinic acid
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-22 Downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, STAT3 Inhibitor
[+]

Rosmarinic acid mitigates lipopolysaccharide-induced neuroinflammatory responses.Jan 08, 2018

Pubmed Data : Inflammation. 2018 Jan 9. Epub 2018 Jan 9. PMID: 29318480
Article Published Date : Jan 08, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Rosmarinic acid
Diseases : Brain Inflammation , Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Royal jelly showed anti-inflammatory and antioxidant properties in experimental colitisDec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : ScientificWorldJournal. 2015 ;2015:956235. Epub 2015 Mar 2. PMID: 25821860
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Royal Jelly
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Ruta graveolens extract had anti-inflammatory and antioxidant activity, with potent inhibitory effects on the arachidonic acid pathways.Feb 28, 2014

Pubmed Data : Chin J Nat Med. 2014 Mar ;12(3):172-9. PMID: 24702802
Article Published Date : Feb 28, 2014
Study Type : Animal Study
Additional Links
Substances : Ruta Graveolens
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Rutin ameliorated the schemia-reperfusion induced ovarian injury.Mar 21, 2018

Pubmed Data : Gynecol Endocrinol. 2018 Mar 22:1-6. Epub 2018 Mar 22. PMID: 29564969
Article Published Date : Mar 21, 2018
Study Type : Animal Study
Additional Links
Substances : Rutin
Diseases : Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Rutin exhibits significant physiological, biochemical and immunological protection against Methotrexate induced intestinal toxicity.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2016 ;16:99. Epub 2016 Mar 10. PMID: 26965456
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Rutin
Diseases : Drug-Induced Toxicity: Methotrexate
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
[+]

Salvianolic acid B inhibits high-fat diet-induced inflammation by activating the Nrf2 pathway.Jul 31, 2017

Pubmed Data : J Food Sci. 2017 Aug ;82(8):1953-1960. Epub 2017 Jul 28. PMID: 28753232
Article Published Date : Jul 31, 2017
Study Type : Animal Study
Additional Links
Substances : Red Sage
Diseases : High Fat Diet, Inflammation, Oxidative Stress
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-10 downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Saturated fatty acids, palm oil and medium chain triglycerides, reverse inflammatory and fibrotic changes in rat liver despite continued ethanol administration.Nov 01, 2001

Pubmed Data : J Pharmacol Exp Ther. 2001 Nov;299(2):638-44. PMID: 11602676
Article Published Date : Nov 01, 2001
Study Type : Animal Study
Additional Links
Substances : Medium Chain Triglycerides, Palm Oil, Saturated fatty acids
Diseases : Alcoholic Liver Disease
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Beneficial Saturated Fats
[+]

Sea buckthorn can be used as a therapeutic agent in inflammatory diseases.Apr 12, 2017

Pubmed Data : Inflammopharmacology. 2017 Apr 13. Epub 2017 Apr 13. PMID: 28409391
Article Published Date : Apr 12, 2017
Study Type : Animal Study
Additional Links
Substances : Sea buckthorn
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interferon Gamma Reducer, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Selenium-rich yeast protects against aluminum-induced peroxidation of lipide and inflammation in mice liver.Oct 03, 2018

Pubmed Data : Biometals. 2018 Oct 4. Epub 2018 Oct 4. PMID: 30288658
Article Published Date : Oct 03, 2018
Study Type : Animal Study
Additional Links
Substances : Selenium, Yeast
Diseases : Aluminum Toxicity , Chemically-Induced Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Hepatoprotective, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Aluminum
[+]

Sesamol suppresses cyclooxygenase-2 transcriptional activity in colon cancer cells.Feb 28, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Biochem Nutr. 2014 Mar ;54(2):95-101. Epub 2014 Feb 19. PMID: 24688218
Article Published Date : Feb 28, 2014
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Colon Cancer
Pharmacological Actions : Chemopreventive, Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation
[+]

Silibinin inhibits lung tumor angiogenesis in an animal model.Jun 20, 2006

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Natl Cancer Inst. 2006 Jun 21 ;98(12):846-55. PMID: 16788158
Article Published Date : Jun 20, 2006
Study Type : Animal Study
Additional Links
Substances : Silibinin
Diseases : Inflammation, Lung Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors, Vascular Endothelial Growth Factor Inhibitors
[+]

Sour cherry juice has antioxidant and anti-inflammatory activity. Dec 01, 2009

Pubmed Data : Plant Foods Hum Nutr. 2009 Dec;64(4):231-7. PMID: 19763832
Article Published Date : Dec 01, 2009
Study Type : Animal Study
Additional Links
Substances : Sour Cherry
Diseases : Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts
[+]

Sulforaphane exhibits chemopreventive properties against intestinal polyps in mice.Dec 01, 2006

Pubmed Data : Biopharm Drug Dispos. 2006 Dec;27(9):407-20. PMID: 16952200
Article Published Date : Dec 01, 2006
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Adenomatous Polyposis Coli, Intestinal Polyps
Pharmacological Actions : Anticarcinogenic Agents, Cyclooxygenase 2 Inhibitors
[+]

Sulforaphane may be a potential a candidate for use in the treatment of acute lung injury.Dec 31, 2015

Pubmed Data : Int J Mol Med. 2016 Jan ;37(1):182-8. Epub 2015 Oct 27. PMID: 26531002
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-E2-Related Factor-2 (Nrf2) Modulator, Prostaglandin PGE2 downregulation
[+]

Supplementation with probiotics was able to reduce tumor incidence, tumor multiplicity and average tumor size.Apr 30, 2015

Pubmed Data : Nutr Cancer. 2015 May-Jun;67(4):603-11. Epub 2015 Mar 26. PMID: 25811420
Article Published Date : Apr 30, 2015
Study Type : Animal Study
Additional Links
Substances : Lactobacillus rhamnosus , Probiotics
Diseases : Colon Cancer, Colon Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Cyclooxygenase 2 Inhibitors
Additional Keywords : Supplementation
[+]

Taheebo polyphenols attenuate free fatty acid-induced inflammation.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Nutr. 2017 ;4:63. Epub 2017 Dec 12. PMID: 29312947
Article Published Date : Dec 31, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Pau D'Arco
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
[+]

Tetramethylpyrazine ameliorates rotenone-induced Parkinson’s disease.Aug 31, 2017

Pubmed Data : Mol Neurobiol. 2017 Sep ;54(7):4866-4878. Epub 2016 Aug 11. PMID: 27514753
Article Published Date : Aug 31, 2017
Study Type : Animal Study
Additional Links
Substances : Ligustrazine
Diseases : Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Neuroprotective Agents, NF-kappaB Inhibitor, Nrf2 activation
[+]

The antioxidant and anti-inflammatory roles of zingerone protect against ethanol-induced hepatotoxicity.Sep 30, 2016

Pubmed Data : Mol Cell Biochem. 2016 Oct ;421(1-2):169-81. Epub 2016 Aug 20. PMID: 27544404
Article Published Date : Sep 30, 2016
Study Type : Animal Study
Additional Links
Substances : Ginger, Polyphenols
Diseases : Alcohol Toxicity , Lipid Peroxidation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

The concomitant reduction in COX-2 expression in paw tissues suggested kaempferol's role in mitigation of inflammation by targeting STAT3 and NF-κB.Nov 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biochem Biophys Rep. 2017 Dec ;12:54-61. Epub 2017 Aug 26. PMID: 28955792
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Kaempferol
Diseases : Inflammation
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, NF-kappaB Inhibitor, STAT3 Inhibitor
[+]

The ethanolic extract of Justicia gendarussa showed significant anti-arthritic activity that was statistically similar to that of aspirin.Dec 31, 2008

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clinics (Sao Paulo). 2009 ;64(4):357-62. PMID: 19488595
Article Published Date : Dec 31, 2008
Study Type : Animal Study
Additional Links
Substances : Justicia gendarussa
Diseases : Arthritis
Pharmacological Actions : 5-Lipoxygenase Inhibitor, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
Additional Keywords : Natural Substances Versus Drugs, Plant Extracts
[+]

The flower extract of Rosa rugosa may be a beneficial anti-inflammatory agent.Feb 29, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomol Ther (Seoul). 2016 Mar 1 ;24(2):184-90. PMID: 26797110
Article Published Date : Feb 29, 2016
Study Type : Animal Study
Additional Links
Substances : Rose
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

The present data suggest that apocynin possesses a potential anti-hepatocarcinogenic property.May 31, 2017

Pubmed Data : Toxicol Pathol. 2017 Jun ;45(4):544-550. Epub 2017 Jun 2. PMID: 28573935
Article Published Date : May 31, 2017
Study Type : Animal Study
Additional Links
Substances : Apocynin
Diseases : Liver Cancer
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors
[+]

The present investigation provides pharmacological evidence to support the folklore claim that J. gendarussa is an anti-inflammatory agent.Jun 30, 2011

Pubmed Data : J Nat Med. 2011 Jul ;65(3-4):471-9. Epub 2011 Mar 17. PMID: 21416126
Article Published Date : Jun 30, 2011
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Justicia gendarussa
Diseases : Inflammation
Pharmacological Actions : 15-Lipoxygenase (15-LOX) Inhibitor, 5-Lipoxygenase Inhibitor, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Prostaglandin PGE2 downregulation
Additional Keywords : Folk Medicine, Plant Extracts
[+]

The present study concluded that Spirulina is able to restrain the changes produced through adjuvant-induced arthritis.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(4):e0121523. Epub 2015 Apr 8. PMID: 25853428
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Spirulina
Diseases : Arthritis
Pharmacological Actions : Anti-Angiogenic, Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Vascular Endothelial Growth Factor Inhibitors
[+]

The protective effects of magnolol on acute trinitrobenzene sulfonic acid‑induced colitis in rats.Feb 28, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2018 Mar ;17(3):3455-3464. Epub 2017 Dec 20. PMID: 29286109
Article Published Date : Feb 28, 2018
Study Type : Animal Study
Additional Links
Substances : Magnolol
Diseases : Colitis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation
[+]

The results indicate that cultivation techniques remarkably affect the hepatoprotective activities of Antrodia camphorata.Jul 11, 2017

Pubmed Data : J Ethnopharmacol. 2017 Jul 12 ;206:31-39. Epub 2017 May 12. PMID: 28506899
Article Published Date : Jul 11, 2017
Study Type : Animal Study
Additional Links
Substances : Antrodia camphorata
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These findings confirm the chemopreventive potential of chrysin against benzo(a)pyrene induced lung cancer in Swiss albino mice.Mar 31, 2016

Pubmed Data : Pharmacol Rep. 2016 Apr ;68(2):310-8. Epub 2015 Sep 6. PMID: 26922533
Article Published Date : Mar 31, 2016
Study Type : Animal Study
Additional Links
Substances : Chrysin
Diseases : Lung Cancer, Lung Cancer: Prevention
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
Problem Substances : Benzo(a)pyrene
[+]

These findings confirmed the anti-inflammatory effects of resveratrol and quercetin in BLM-induced lung damage.Aug 31, 2015

Pubmed Data : Br J Nutr. 2015 Sep ;114(6):853-865. PMID: 26334388
Article Published Date : Aug 31, 2015
Study Type : Animal Study
Additional Links
Substances : Mangiferin, Quercetin, Resveratrol
Diseases : Pulmonary Fibrosis, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
[+]

These findings demonstrate that beta-caryophylleneprovides neuroprotection against rotenone-induced Parkinson disease.Jun 30, 2016

Pubmed Data : Mol Cell Biochem. 2016 Jul ;418(1-2):59-70. Epub 2016 Jun 17. PMID: 27316720
Article Published Date : Jun 30, 2016
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Brain Inflammation , Oxidative Stress, Parkinson's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Neuroprotective Agents
[+]

These findings strongly suggest that the anti-inflammatory actions of Thymoquinone are caused by suppression of IRAK-linked AP-1/NF-κB pathways.Feb 19, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Feb 20 ;7:42995. Epub 2017 Feb 20. PMID: 28216638
Article Published Date : Feb 19, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Thymoquinone
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Inflammation, Interleukin-1 beta downregulation, thymoquinone
[+]

These findings suggest that shikonin has therapeutic potential for osteoarthritis.Sep 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2016 Oct ;12(4):2735-2740. Epub 2016 Aug 31. PMID: 27703516
Article Published Date : Sep 30, 2016
Study Type : Animal Study
Additional Links
Substances : Shikonin
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These findings suggest the potential use of p-coumaric acid as a preventive and therapeutic medicine for depression.May 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Neurobiol. 2018 Jun ;27(3):189-199. Epub 2018 Jun 30. PMID: 30022870
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Depression, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Brain-derived neurotrophic factor modulator, Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These results demonstrate that grape juice concentrate modulates rat tongue carcinogenesis.Apr 30, 2014

Pubmed Data : Toxicol Mech Methods. 2014 May ;24(4):276-83. Epub 2014 Jan 28. PMID: 24401099
Article Published Date : Apr 30, 2014
Study Type : Animal Study
Additional Links
Substances : Grape
Diseases : Tongue Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antioxidants, Antiproliferative , Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These results indicate that shikonin treatment may prevent the loss of vision associated with diabetic retinopathy.Mar 20, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Mar 21 ;7:44985. Epub 2017 Mar 21. PMID: 28322323
Article Published Date : Mar 20, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Shikonin
Diseases : Diabetic Retinopathy
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
Additional Keywords : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Diabetic Retinopathy, Shikonin
[+]

These results indicate the potential antidiabetic benefits of M. oleifera ethanolic leaf extract.May 02, 2017

Pubmed Data : J Med Food. 2017 May 3. Epub 2017 May 3. PMID: 28467233
Article Published Date : May 02, 2017
Study Type : Animal Study
Additional Links
Substances : Moringa oleifera
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, Hypoglycemic Agents, Hypolipidemic, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Renoprotective
Additional Keywords : Plant Extracts
[+]

These results indicate the potential of compounds from Quercus gilva Bume in the treatment of urolithiasis.Jul 04, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2017 Jul 5 ;22(7). Epub 2017 Jul 5. PMID: 28678204
Article Published Date : Jul 04, 2017
Study Type : Animal Study
Additional Links
Substances : Oak
Diseases : Urolithiasis
Pharmacological Actions : Anti-Inflammatory Agents, Antiurolithiatic, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation
Additional Keywords : Dose Response
[+]

These results provide powerful evidence for the chemopreventive efficacy of Chrysin against chemically induced renal carcinogenesis.Jul 08, 2016

Pubmed Data : Arch Biochem Biophys. 2016 Jul 9. Epub 2016 Jul 9. PMID: 27403965
Article Published Date : Jul 08, 2016
Study Type : Animal Study
Additional Links
Substances : Chrysin
Diseases : Kidney Cancer, Kidney Cancer: Prevention
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Antioxidants, Apoptotic, Bcl-2 protein down-regulation, Chemopreventive, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These results provide scientific evidence for the use of E. longifolia as a potential analgesic and anti-inflammatory agent.Feb 29, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arch Pharm Res. 2016 Mar ;39(3):421-8. Epub 2016 Jan 30. PMID: 26832325
Article Published Date : Feb 29, 2016
Study Type : Animal Study
Additional Links
Substances : Tongkat Ali
Diseases : Inflammation
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
Additional Keywords : Dose Response, Superiority of Natural Substances versus Drugs
Problem Substances : Diclofenac
[+]

These results suggest that the anti-inflammatory effect of delphinidin alleviated inflammation in a spinal cord injury model.Nov 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2017 Dec ;14(6):5583-5588. Epub 2017 Sep 27. PMID: 29285096
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Delphinidin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation
[+]

This study demonstrated the anti-arthritic, anti-inflammatory, anti-oxidative stress and chondro-protective potentials of sesamol in vivo. Sep 30, 2013

Pubmed Data : Eur J Nutr. 2013 Oct ;52(7):1787-99. Epub 2012 Dec 27. PMID: 23269651
Article Published Date : Sep 30, 2013
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Arthritis, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chondroprotective, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

This study indicates that a methanol extract from Inonotus obliquus has anti-inflammatory and anti-nociceptive properties.Oct 02, 2005

Pubmed Data : J Ethnopharmacol. 2005 Oct 3 ;101(1-3):120-8. PMID: 15905055
Article Published Date : Oct 02, 2005
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Chaga Mushroom (Inonotus obliquus)
Diseases : Inflammation
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Antinoceceptive , Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Thuja orientalis reduces airway inflammation in ovalbumin-induced allergic asthma.Aug 31, 2015

Pubmed Data : Mol Med Rep. 2015 Sep ;12(3):4640-4646. Epub 2015 Jun 11. PMID: 26063078
Article Published Date : Aug 31, 2015
Study Type : Animal Study
Additional Links
Substances : Thuja
Diseases : Asthma, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, interleukin-13 down-regulation, Interleukin-4 downregulation, Interleukin-5 downregulation, Matrix metalloproteinase-9 (MMP-9) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Thymol mitigates lipopolysaccharide-induced endometritis.Mar 20, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Mar 21 ;8(12):20042-20055. PMID: 28223539
Article Published Date : Mar 20, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Thymol
Diseases : Endometritis, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Thymoquinone abolishes a number of factors known to be involved in rheumatoid arthritis pathogenesis.Dec 31, 2010

Pubmed Data : J Cell Biochem. 2011 Jan ;112(1):107-17. PMID: 20872780
Article Published Date : Dec 31, 2010
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Inflammation, Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Anti-Inflammatory Agents, Antiproliferative, Inflammation, rheumatoid arthritis, thymoquinone
[+]

Thymoquinone augmented the chemopreventive effect of vitamin D during the initiation phase of colon cancer.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2017 ;9(2):774-790. Epub 2017 Feb 15. PMID: 28337306
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Thymoquinone, Vitamin D
Diseases : Colon Cancer
Pharmacological Actions : Chemopreventive, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Natural Substance Synergy
[+]

Thymoquinone could confer intestinal protection against methotrexate induced mucositis.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacogn Mag. 2016 Jan ;12(Suppl 1):S76-81. PMID: 27041864
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Drug Toxicity: Methotrexate
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Apoptotic, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Thymoquinone inhibits LoVo cancer cell growth and migration.Feb 20, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2017 Feb 21 ;23(7):1171-1179. PMID: 28275297
Article Published Date : Feb 20, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Thymoquinone
Diseases : Colon Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Antiproliferative , Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation
Additional Keywords : Dose Response
[+]

Thymoquinone reduces spinal cord injury by inhibiting inflammatory response, oxidative stress and apoptosis May 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2018 Jun ;15(6):4987-4994. Epub 2018 Apr 16. PMID: 29904397
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Tormentic acid may be a potential therapeutic candidate for the prevention of acetaminophen induced liver injury.May 17, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2017 May 18 ;22(5). Epub 2017 May 18. PMID: 28524081
Article Published Date : May 17, 2017
Study Type : Animal Study
Additional Links
Substances : Loquat
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Acetaminophen, Paracetamol
[+]

Total flavonoids from Rosa laevigata fruit exhibited protective effect against lipopolysaccharide-induced liver injury.Jun 07, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Foods. 2018 Jun 8 ;7(6). Epub 2018 Jun 8. PMID: 29890650
Article Published Date : Jun 07, 2018
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Rose
Diseases : Chemically-Induced Liver Damage, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation
[+]

Treatment with taraxasterol significantly increased the pain thresholds and reduced the clinical arthritic scores of mice.Nov 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2016 Dec ;12(6):4035-4040. Epub 2016 Nov 2. PMID: 28101182
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Substances : Dandelion
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Ultralow doses of cannabinoid drugs protect the mouse brain from inflammation-induced cognitive damage.Nov 30, 2014

Pubmed Data : J Neurosci Res. 2014 Dec ;92(12):1669-77. Epub 2014 Jul 16. PMID: 25042014
Article Published Date : Nov 30, 2014
Study Type : Animal Study
Additional Links
Substances : Delta-tetrahydrocannabinol (THC)
Diseases : Brain Inflammation , Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Neuroprotective Agents
[+]

Vitamin C has protective effects against spinal cord injury-induced kidney damage.Mar 31, 2015

Pubmed Data : Neurol Sci. 2015 Apr ;36(4):521-6. Epub 2014 Nov 18. PMID: 25403314
Article Published Date : Mar 31, 2015
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Vitamin D3 and 5-FU synergise together and exhibit better anticancer effects by modulating Wnt/β-catenin pathway.Jul 24, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Exp Clin Cancer Res. 2015 Jul 25 ;34:71. Epub 2015 Jul 25. PMID: 26205949
Article Published Date : Jul 24, 2015
Study Type : Animal Study
Additional Links
Substances : Vitamin D
Diseases : Colon Cancer
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Heat Shock Protein Down-Regulation, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Walnut leaf extract exert protective effects against diabetic retinopathy.Oct 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2017 Nov ;20(11):1275-1281. PMID: 29299206
Article Published Date : Oct 31, 2017
Study Type : Animal Study
Additional Links
Substances : Walnut
Diseases : Diabetic Retinopathy
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
Additional Keywords : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Diabetic Retinopathy, Walnut
[+]

Walnuts reduced prostate tumor growth by affecting energy metabolism along with decreased plasma IGF-1 and cholesterol.Nov 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Med Food. 2014 Dec ;17(12):1281-6. PMID: 25354213
Article Published Date : Nov 30, 2014
Study Type : Transgenic Animal Study
Additional Links
Substances : Walnut
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative , Chemopreventive, Cyclooxygenase 2 Inhibitors
Additional Keywords : Dietary Concentrations
[+]

Wogonin and 5-fluorouracil combination treatment caused a significant growth inhibition of human tumor xenografts in vivo.Jul 31, 2013

Pubmed Data : Biochem Cell Biol. 2013 Aug ;91(4):221-9. Epub 2013 Feb 14. PMID: 23859016
Article Published Date : Jul 31, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Chemosensitizer, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors
Additional Keywords : Drug: 5-flourouracil, Natural Substance/Drug Synergy, Plant Extracts
[+]

Wogonin prevents alcohol-induced gastric mucosal damage in rats. Aug 01, 2008

Pubmed Data : Appl Environ Microbiol. 2008 Aug;74(15):4650-5. Epub 2008 Jun 6. PMID: 15139485
Article Published Date : Aug 01, 2008
Study Type : Animal Study
Additional Links
Substances : Wogonin
Diseases : Alcohol Toxicity
Pharmacological Actions : Apoptotic, Cyclooxygenase 2 Inhibitors
[+]

Zerumbone possesses anti-inflammatory and antinociceptive effects.Feb 17, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2016 Feb 18 ;17(2):249. Epub 2016 Feb 18. PMID: 26901193
Article Published Date : Feb 17, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Zerumbone
Diseases : Arthritis, Lipopolysaccharide-Induced Toxicity, Osteoarthritis
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor
[+]

Zerumbone reduced the inflammatory response of acute lung injury in endotoxin-treated mice.Apr 21, 2017

Pubmed Data : Chem Biol Interact. 2017 Apr 22 ;271:9-14. Epub 2017 Apr 22. PMID: 28442377
Article Published Date : Apr 21, 2017
Study Type : Animal Study
Additional Links
Substances : Zerumbone
Diseases : Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Zingerone ameliorates cisplatin-induced ovarian and uterine toxicity.May 31, 2018

Pubmed Data : Biomed Pharmacother. 2018 Jun ;102:517-530. Epub 2018 Mar 26. PMID: 29587238
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : Ginger, Polyphenols
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Anti-Inflammatory Agents, Chemoprotective Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

α-solanine may be a promising therapeutic against inflammatory diseases by inhibiting the NF-κB signaling pathway.Mar 01, 2016

Pubmed Data : J Cell Biochem. 2016 Mar 2. Epub 2016 Mar 2. PMID: 26931732
Article Published Date : Mar 01, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Potato
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Sepsis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

β-patchoulene isolated from patchouli oil had Anti-inflammatory activity.Apr 13, 2016

Pubmed Data : Eur J Pharmacol. 2016 Apr 14. Epub 2016 Apr 14. PMID: 27090925
Article Published Date : Apr 13, 2016
Study Type : Animal Study
Additional Links
Substances : Patchouli
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Dose Response, Plant Oils
[+]

ω-3 polyunsaturated fatty acids had inhibitory effects on endometrial cancer development.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2015;5:14958. Epub 2015 Oct 15. PMID: 26468779
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Endometrial Cancer
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation
Additional Keywords : Risk Reduction
[+]

"Anti-inflammatory effects of fucoidan through inhibition of NF-κB, MAPK and Akt activation in lipopolysaccharide-induced BV2 microglia cells."Jul 31, 2011

Pubmed Data : Food Chem Toxicol. 2011 Aug ;49(8):1745-52. Epub 2011 May 4. PMID: 21570441
Article Published Date : Jul 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Fucoidan
Diseases : Brain: Microglial Activation, Brain Inflammation , Lipopolysaccharide-Induced Toxicity, Neurodegenerative Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

"Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells."Jul 31, 2012

Pubmed Data : J Pineal Res. 2012 Aug ;53(1):77-90. Epub 2012 Feb 16. PMID: 22335196
Article Published Date : Jul 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Melatonin
Diseases : Breast Cancer
Pharmacological Actions : Antioxidants, Antiproliferative , Apaf-1/caspase-dependent apoptotic pathway activator, Apoptotic, Cyclooxygenase 2 Inhibitors, p300/NF-κB down-regulation, PI3K/Akt/signaling suppression
[+]

18β-Glycyrrhetinic acid may be used as a chemopreventive agent in liver cancer.Apr 25, 2016

Pubmed Data : Mol Cell Biochem. 2016 Apr 26. Epub 2016 Apr 26. PMID: 27116616
Article Published Date : Apr 25, 2016
Study Type : In Vitro Study
Additional Links
Substances : 18β-Glycyrrhetinic Acid
Diseases : Liver Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Apoptotic, Chemopreventive, Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

A comparative study on hulled adlay and unhulled adlay through evaluation of their LPS-induced anti-inflammatory effects.Feb 28, 2015

Pubmed Data : Chem Biodivers. 2015 Mar ;12(3):380-7. PMID: 25766911
Article Published Date : Feb 28, 2015
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Nitric Oxide Inhibitor
Additional Keywords : Plant Extracts
[+]

A guava leaf extract contains potential therapeutic agents, which regulate NF-κB activation, for the treatment of inflammatory conditions.Oct 31, 2015

Pubmed Data : Fish Shellfish Immunol. 2015 Nov ;47(1):85-92. Epub 2015 Aug 29. PMID: 26327113
Article Published Date : Oct 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Guava
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-10 downregulation, Interleukin-1 beta downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Dose Response, Plant Extracts
[+]

A hexane fraction of P. vulgaris var. lilacina may be a potent anti-inflammatory candidate.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2013 ;14(11):21489-503. Epub 2013 Oct 30. PMID: 24177568
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Prunella vulgaris
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Prostaglandin PGE2 downregulation
Additional Keywords : Plant Extracts
[+]

A polar extract of Curcuma longa protects cartilage homeostasisJan 07, 2018

Pubmed Data : Inflammopharmacology. 2018 Jan 8. Epub 2018 Jan 8. PMID: 29313174
Article Published Date : Jan 07, 2018
Study Type : In Vitro Study