Cyclooxygenase 2 Inhibitors

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176 Substances Researched for Cyclooxygenase 2 Inhibitors
NameACCKFocus
Curcumin6187Locked
Flavonoids1327Locked
Resveratrol1723Locked
Omega-3 Fatty Acids617Locked
Sulforaphane1114Locked
Apples212Locked
DHA (Docosahexaenoic Acid)312Locked
Spirulina212Locked
EPA (Eicosapentaenoic Acid)211Locked
Turmeric211Locked
Eicosapentaenoic acid (EPA) 110Locked
Frankincense110Locked
Polyphenols610Locked
Strawberry110Locked
Vitamin C110Locked
Stilbenes58Locked
Cannabis37Locked
Melatonin46Locked
Astaxanthin35Locked
Berberine35Locked
Chrysin35Locked
Ginger35Locked
Noni35Locked
Pterostilbene45Locked
Wogonin35Locked
Anthocyanins24Locked
Black Tea34Locked
Bromelain44Locked
Dandelion 44Locked
Flaxseed24Locked
Fucoidan34Locked
Ginkgo biloba24Locked
Lignans24Locked
Medium Chain Triglycerides24Locked
Nobiletin 34Locked
Palm Oil24Locked
Pomegranate34Locked
Quercetin34Locked
Saturated fatty acids24Locked
Sweet Potato: Purple24Locked
Thymoquinone24Locked
18β-Glycyrrhetinic Acid23Locked
Antrodia camphorata23Locked
Apigenin23Locked
Blueberry23Locked
Chaga Mushroom (Inonotus obliquus)23Locked
Chinese Skullcap 23Locked
Citrus Peel 23Locked
Fermented Foods and Beverages23Locked
Ginseng (American)23Locked
Ginseng (Korean)33Locked
Mangiferin23Locked
Rose 23Locked
Saffron23Locked
ALA (Alpha-Linolenic Acid)12Locked
Alpha Linolenic Acid12Locked
Apple Polyphenols12Locked
Arginine12Locked
Artemisia asiatica12Locked
Bee Propolis12Locked
Benzyl isothiocyanate 12Locked
Boswellia12Locked
Brown Rice12Locked
Burdock12Locked
Caffeic acid phenethyl ester12Locked
Carrot12Locked
Catechin 22Locked
Cocoa12Locked
Crocetin12Locked
Cyanidin 3-glucoside12Locked
Damnacanthal12Locked
EGCG (Epigallocatechin gallate)22Locked
Evening Primrose Oil12Locked
Fisetin22Locked
Fucoxanthin 12Locked
Garcinia indica12Locked
Gardenia12Locked
Garlic12Locked
Gingerol 12Locked
Grape Seed Extract12Locked
Graviola 12Locked
Guggul22Locked
Hops12Locked
Kaempferia parviflora12Locked
L-Carnitine12Locked
Lactobacillus rhamnosus 12Locked
Lion's Mane (Hericium Erinaceus)12Locked
Moringa oleifera12Locked
Mulberry12Locked
Myricetin12Locked
Noni leaf extract12Locked
Patchouli12Locked
Peony12Locked
Perilla 12Locked
Pine Needle12Locked
Polyunsaturated Fatty Acids (PUFAs)12Locked
Potato12Locked
Probiotics12Locked
Raspberry12Locked
Red Wine12Locked
Rice Bran12Locked
Rosmarinic acid12Locked
Royal Jelly12Locked
Rutin12Locked
Sour Cherry12Locked
Tangeretin 12Locked
Tongkat Ali12Locked
Walnut12Locked
Achillea fragrantissima11Locked
Alpha-Lipoic Acid11Locked
Artesunate11Locked
Asparagus11Locked
Avenanthramides11Locked
Avocado11Locked
Bamboo11Locked
Bee Venom11Locked
Beta-glucan11Locked
Betulinic acid11Locked
Black Pepper11Locked
Butterbur11Locked
Capsaicin11Locked
Chamomile11Locked
Cucurbitacin B 11Locked
Cumin11Locked
Cyanidin11Locked
Echinacea11Locked
Ferulic acid11Locked
Feverfew11Locked
Fish Oil11Locked
Fruit: All11Locked
Ginsenosides11Locked
Gleditsia sinensis11Locked
Guava11Locked
Horseradish11Locked
Huperzine11Locked
Hyaluronic Acid11Locked
Hydroxytyrosol11Locked
Kava Kava11Locked
Kimchi11Locked
Long Pepper11Locked
Loquat Leaves11Locked
Lutein11Locked
Luteolin11Locked
Maitake Mushroom11Locked
Medicinal Mushrooms11Locked
Mushrooms: All 11Locked
Mussel: Green-lipped (Perna canaliculus)11Locked
Oats11Locked
Oleuropein11Locked
Olive11Locked
Orange: Mandarin11Locked
Oranges11Locked
Phenethyl isothiocyanate11Locked
Piceatannol 11Locked
Piperlongumine 11Locked
Plantago11Locked
Prunella vulgaris.11Locked
Purple Carrots11Locked
Reishi Mushroom11Locked
Rice: Black 11Locked
Rose Hips11Locked
Saw Palmetto11Locked
Sesame Seeds11Locked
Soy11Locked
Tabebuia11Locked
Theaflavins11Locked
Tocotrienol: Gamma11Locked
Toona sinensis 11Locked
Truffles11Locked
Turmerones11Locked
Tyrosol11Locked
Unsaponifiables 11Locked
Ursolic Acid11Locked
Vegetables: All 11Locked
Wormwood11Locked
Wasabi10Locked

View the Evidence:
366 Abstracts with Cyclooxygenase 2 Inhibitors Research

[+]

A daily dose of 3.6 g curcumin achieves pharmacologically efficacious levels in the colorectum with negligible distribution of curcumin outside the gut.Jan 01, 2005

Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):120-5. PMID: 15668484
Article Published Date : Jan 01, 2005
Study Type : Human Study
Additional Links
Substances : Curcumin
Diseases : Colorectal Cancer
Pharmacological Actions : Chemopreventive, Cyclooxygenase 2 Inhibitors
Additional Keywords : Antineoplastic Agents
[+]

A formulation containing Frankincense and Turmeric extracts demonstrated a greater improvement in the treatment of OA than celecoxib.Oct 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2013 Nov ;8(5):1542-8. Epub 2013 Aug 29. PMID: 24002213
Article Published Date : Oct 31, 2013
Study Type : Human Study
Additional Links
Substances : Frankincense, Turmeric
Diseases : Osteoarthritis: Knee
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts, Superiority of Natural Substances versus Drugs
Problem Substances : Celecoxib, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Consumption of dried apple peel powder was associated with improved joint function and improved serum antioxidant protection status.Oct 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Med Food. 2014 Nov ;17(11):1204-13. Epub 2014 Oct 1. PMID: 25271471
Article Published Date : Oct 31, 2014
Study Type : Human Study
Additional Links
Substances : Apples
Diseases : Joint Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Antinoceceptive , Antioxidants, Cyclooxygenase 2 Inhibitors, Lipoxygenase Inhibitors
Additional Keywords : Plant Extracts, Significant Treatment Outcome
[+]

Dietary strawberries significantly decreased the histologic grade of patients' precancerous esophageal lesions.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Prev Res (Phila). 2012 Jan ;5(1):41-50. Epub 2011 Dec 1. PMID: 22135048
Article Published Date : Dec 31, 2011
Study Type : Human Study
Additional Links
Substances : Strawberry
Diseases : Esophageal Cancer
Pharmacological Actions : Antiproliferative , Chemopreventive, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Nitric Oxide Inhibitor
Additional Keywords : Plant Extracts, Risk Reduction
[+]

Electroacupuncture treatment alleviates central post-stroke pain.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neural Plast. 2016 ;2016:1437148. Epub 2016 Aug 27. PMID: 27774321
Article Published Date : Dec 31, 2015
Study Type : Human Study
Additional Links
Diseases : Stroke: Attenuation/Recovery
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Analgesics, Cyclooxygenase 2 Inhibitors
[+]

EPA supplementation significantly reduces Cox-2 enzyme expression in Barrett's esophagus.Apr 01, 2008

Pubmed Data : Am J Clin Nutr. 2008 Apr;87(4):949-56. PMID: 18400718
Article Published Date : Apr 01, 2008
Study Type : Human Study
Additional Links
Substances : EPA (Eicosapentaenoic Acid)
Diseases : Barrett Esophagus
Pharmacological Actions : Cyclooxygenase 2 Inhibitors
[+]

Omega-3 fatty acids cause a reduction in the mRNA levels for various proteins known to be important in the pathology of osteoarthritis. Jul 01, 2009

Pubmed Data : Osteoarthritis Cartilage. 2009 Jul;17(7):896-905. Epub 2009 Jan 13. PMID: 19217322
Article Published Date : Jul 01, 2009
Study Type : Human Study
Additional Links
Substances : DHA (Docosahexaenoic Acid), Eicosapentaenoic acid (EPA) , Omega-3 Fatty Acids
Diseases : Osteoarthritis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Phloretin inhibits the growth of P. acnes, P. granulosum, and S. epidermidis.Jan 31, 2016

Pubmed Data : Int J Cosmet Sci. 2016 Feb ;38(1):85-92. Epub 2015 Aug 30. PMID: 26212527
Article Published Date : Jan 31, 2016
Study Type : Human In Vitro, Human Study
Additional Links
Substances : Phloretin
Diseases : Acne
Pharmacological Actions : Anti-Bacterial Agents, Antimicrobial, Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation
[+]

Pycnogenol may be of value in treatment of MSU crystal-induced arthritis through its anti-inflammatory and anti-nitrosative activities.Feb 14, 2012

Pubmed Data : Free Radic Biol Med. 2012 Feb 15 ;52(4):765-74. Epub 2011 Dec 13. PMID: 22198264
Article Published Date : Feb 14, 2012
Study Type : Human Study
Additional Links
Substances : Flavonoids
Diseases : Gout, Hyperuricemia
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
[+]

Spirulina has favorable effects on lipid profiles, immune variables and antioxidant capacity in healthy individuals.Jan 01, 2008

Pubmed Data : Ann Nutr Metab. 2008;52(4):322-8. Epub 2008 Aug 19. PMID: 18714150
Article Published Date : Jan 01, 2008
Study Type : Human Study
Additional Links
Substances : Spirulina
Diseases : High Cholesterol
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-2 upregulation, Interleukin-6 Downregulation
[+]

These new data support a potential role of oleuropein in the treatment of ulcerative colitis.Apr 14, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2017 Apr 15 ;9(4). Epub 2017 Apr 15. PMID: 28420140
Article Published Date : Apr 14, 2017
Study Type : Human Study
Additional Links
Substances : Oleuropein
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-17 downregulation
[+]

Vitamin C attenuates aspirin-induced gastric damage. May 01, 2009

Pubmed Data : Zhongguo Zhen Jiu. 2009 May;29(5):382-4. PMID: 17218764
Article Published Date : May 01, 2009
Study Type : Human Study
Additional Links
Substances : Vitamin C
Diseases : Aspirin-Induced Toxicity , NSAID-induced toxicity
Pharmacological Actions : Cyclooxygenase 2 Inhibitors
[+]

Cannabidiolic acid an active component in the cannabis plant offers potential therapeutic modality in the abrogation of cancer cell migration.Nov 14, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxicol Lett. 2012 Nov 15 ;214(3):314-9. Epub 2012 Sep 8. PMID: 22963825
Article Published Date : Nov 14, 2012
Study Type : Human In Vitro
Additional Links
Substances : Cannabis
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Antiproliferative , Cyclooxygenase 2 Inhibitors, Enzyme Inhibitors
[+]

Ginsenoside Rg1 can inhibit inflammatory responses in human chondrocytes in vitro and reduce articular cartilage damage in vivo.Mar 09, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2017 Mar 10 ;9(3). Epub 2017 Mar 10. PMID: 28287423
Article Published Date : Mar 09, 2017
Study Type : Animal Study, Human In Vitro
Additional Links
Substances : Ginsenosides
Diseases : Osteoarthritis
Pharmacological Actions : Chondroprotective, Cyclooxygenase 2 Inhibitors, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Prostaglandin PGE2 downregulation
[+]

Melatonin as a novel selective ATF-6 inhibitor can sensitize human hepatoma cells to ER stress inducing apoptosis.Feb 13, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2017 Feb 14 ;23(6):986-998. PMID: 28246472
Article Published Date : Feb 13, 2017
Study Type : Human In Vitro
Additional Links
Substances : Melatonin
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Cyclooxygenase 2 Inhibitors
[+]

Melatonin is a potential candidate compound for the treatment of proinflammatory disorders.Aug 31, 2012

Pubmed Data : J Pineal Res. 2012 Sep ;53(2):154-65. Epub 2012 Feb 21. PMID: 22348531
Article Published Date : Aug 31, 2012
Study Type : Human In Vitro
Additional Links
Substances : Melatonin
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Dose Response
[+]

Oleuropein might provide a basis for developing a new dietary strategy for the prevention and management of rheumatoid arthritis.Apr 19, 2017

Pubmed Data : Food Funct. 2017 Apr 20. Epub 2017 Apr 20. PMID: 28426090
Article Published Date : Apr 19, 2017
Study Type : Human In Vitro
Additional Links
Substances : Oleuropein
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Matrix metalloproteinase-1 (MMP-1) inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Phloretin inhibits interleukin-1β-induced COX-2 and ICAM-1 in human lung epithelial cells.May 31, 2015

Pubmed Data : Food Funct. 2015 Jun ;6(6):1960-7. PMID: 25996641
Article Published Date : May 31, 2015
Study Type : Human In Vitro
Additional Links
Substances : Phloretin
Diseases : Experimental Lung Inflammation
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Prostaglandin PGE2 downregulation
[+]

Resveratrol functions as a suppressor of particulate matter induced inflammatory signalling pathways.May 07, 2017

Pubmed Data : Int J Biochem Cell Biol. 2017 May 8 ;88:113-123. Epub 2017 May 8. PMID: 28495310
Article Published Date : May 07, 2017
Study Type : Human In Vitro
Additional Links
Substances : Resveratrol
Diseases : Air Pollution Linked Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation
[+]

Berberin inhibited colorectal cancer invasion and metastasis via down regulation of COX-2/PGE2- JAK2/STAT3 signaling pathway.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(5):e0123478. Epub 2015 May 8. PMID: 25954974
Article Published Date : Dec 31, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Berberine
Diseases : Colorectal Cancer
Pharmacological Actions : Anti-metastatic, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Prostaglandin PGE2 downregulation
[+]

"Chrysin abrogates early hepatocarcinogenesis and induces apoptosis in N-nitrosodiethylamine-induced preneoplastic nodules in rats."Feb 15, 2011

Pubmed Data : Toxicol Appl Pharmacol. 2011 Feb 15 ;251(1):85-94. Epub 2010 Dec 15. PMID: 21167192
Article Published Date : Feb 15, 2011
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Liver Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors, Tumor Suppressor Protein p53 Upregulation
[+]

18β-Glycyrrhetinic acid significantly attenuated H. pylori-infected gastritis in gerbils.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2016 ;2016:4943793. Epub 2016 Feb 24. PMID: 27006947
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : 18β-Glycyrrhetinic Acid
Diseases : Helicobacter Pylori Infection
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Gastroprotective, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

5-FU and thymoquinone combination therapy resulted in a more significant reduction on AOM-induced colorectal tumors.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2016 ;10:2239-53. Epub 2016 Jul 11. PMID: 27468227
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Colorectal Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemoprotective Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Vascular Endothelial Growth Factor Inhibitors, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Gene Expression Regulation
[+]

A Burdock extract was able to reduce intestinal inflammation in an acute TNBS-induced experimental model of colitis in rats.Mar 06, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Ethnopharmacol. 2013 Mar 7 ;146(1):300-10. Epub 2013 Jan 10. PMID: 23313393
Article Published Date : Mar 06, 2013
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Phytotherapy, Plant Extracts
[+]

A combination of ginger and peony root may prevent memory impairment in AD by inhibiting Aβ accumulation and inflammation in the brain.Nov 29, 2015

Pubmed Data : J Alzheimers Dis. 2015 Nov 30. Epub 2015 Nov 30. PMID: 26639976
Article Published Date : Nov 29, 2015
Study Type : Transgenic Animal Study
Additional Links
Substances : Ginger, Peony
Diseases : Alzheimer's Disease, Brain Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts
[+]

Allylmethylsulfide (AMS), a volatile organosulfur derivative from garlic has radioprotective properties.Jun 01, 2009

Pubmed Data : J Med Food. 2009 Jun;12(3):542-51. PMID: 19627202
Article Published Date : Jun 01, 2009
Study Type : Animal Study
Additional Links
Substances : Garlic
Diseases : Lipid Peroxidation, Radiation Induced Illness
Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Radioprotective, Vascular Cell Adhesion Molecule-1 Inhibitor
Additional Keywords : Plant Extracts
[+]

Alpha linolenic fatty acid supplementation had a beneficial effect on tumor cell proliferation and cachexia parameters.May 25, 2015

Pubmed Data : Nutr Cancer. 2015 May 26:1-8. Epub 2015 May 26. PMID: 26011096
Article Published Date : May 25, 2015
Study Type : Animal Study
Additional Links
Substances : Alpha Linolenic Acid
Diseases : Breast Cancer, Cachexia
Pharmacological Actions : Antiproliferative , Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

American ginseng prevents and treats Ulcerative Colitis.Sep 18, 2008

Pubmed Data : Carcinogenesis. 2008 Sep 18. [Epub ahead of print] PMID: 18802031
Article Published Date : Sep 18, 2008
Study Type : Animal Study
Additional Links
Substances : Ginseng (American)
Diseases : Colitis: Pseudomembranous, Ulcerative Colitis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Nitric Oxide Inhibitor, Tumor Suppressor Protein p53 Upregulation
[+]

Anthocyanin-rich fractions from red raspberries attenuate inflammation both in vitro and in vivo.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2014 ;4:6234. Epub 2014 Aug 29. PMID: 25167935
Article Published Date : Dec 31, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Anthocyanins, Raspberry
Diseases : Colitis, Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor
Additional Keywords : Plant Extracts
[+]

Anti-inflammatory mechanisms could be involved in pomegranate-mediated prevention of breast cancer.Apr 27, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2017 Apr 28 ;9(5). Epub 2017 Apr 28. PMID: 28452959
Article Published Date : Apr 27, 2017
Study Type : Animal Study
Additional Links
Substances : Pomegranate
Diseases : Breast Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Heat Shock Protein Down-Regulation
[+]

Antrodia camphorata extract, when combined with anti-tumor agents, showed adjuvant antiproliferative effects on multi-drug resistant hepatoma. Aug 13, 2008

Pubmed Data : J Ethnopharmacol. 2008 Aug 13;118(3):387-95. Epub 2008 May 7. PMID: 18571350
Article Published Date : Aug 13, 2008
Study Type : Animal Study
Additional Links
Substances : Antrodia camphorata
Diseases : Cancers: Multi-Drug Resistant, Liver Cancer
Pharmacological Actions : Antineoplastic Agents, Cell cycle arrest, Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts
[+]

Apigenin and myricetin exhibited a protective and promising preventive strategy against cisplatin-induced nephrotoxicity.Nov 30, 2017

Pubmed Data : Pharm Biol. 2017 Dec ;55(1):766-774. PMID: 28064632
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Apigenin, Flavonoids, Myricetin
Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Oxidative Stress
Pharmacological Actions : Chemoprotective Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Apigenin, a dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation in mice. Jan 01, 2009

Pubmed Data : Arthritis Res Ther. 2009;11(2):R59. Epub 2009 Apr 30. PMID: 19405952
Article Published Date : Jan 01, 2009
Study Type : Animal Study
Additional Links
Substances : Apigenin
Diseases : Autoimmune Diseases, Lupus Erythematosus: Systemic
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Apple polyphenols extract (APE) improves colon damage in a rat model of colitis.Feb 28, 2012

Pubmed Data : Dig Liver Dis. 2012 Feb 28. Epub 2012 Feb 28. PMID: 22381211
Article Published Date : Feb 28, 2012
Study Type : Animal Study
Additional Links
Substances : Apple Polyphenols
Diseases : Colitis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Apples rich polyphenols reduce colonic inflammation in rats. Dec 01, 2009

Pubmed Data : Br J Nutr. 2009 Dec;102(11):1620-8. Epub 2009 Jul 22. PMID: 19622193
Article Published Date : Dec 01, 2009
Study Type : Transgenic Animal Study
Additional Links
Substances : Apples, Flavonoids, Polyphenols
Diseases : Inflammatory Bowel Diseases, Irritable Bowel Syndrome
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
[+]

Arginine reverses ethanol-induced inflammatory and fibrotic changes in liver despite continued ethanol administration.Dec 01, 2001

Pubmed Data : J Pharmacol Exp Ther. 2001 Dec;299(3):832-9. PMID: 11714866
Article Published Date : Dec 01, 2001
Study Type : Animal Study
Additional Links
Substances : Arginine
Diseases : Alcoholic Liver Disease, Inflammation, Liver Fibrosis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Artemisia extracts were mucoprotective by attenuating stress related mucosal damages.Feb 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Biochem Nutr. 2015 Mar ;56(2):132-42. Epub 2014 Nov 28. PMID: 25759519
Article Published Date : Feb 28, 2015
Study Type : Animal Study
Additional Links
Substances : Artemisia asiatica
Diseases : Gastrointestinal Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Gastroprotective, Nrf2 activation
Additional Keywords : Dose Response
[+]

Ascorbic acid contributes to the reduction of oxidative stress and inflammatory response in DSS-induced colitis.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Clin Exp Med. 2015 ;8(11):20245-53. Epub 2015 Nov 15. PMID: 26884937
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Gastrointestinal Inflammation, Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Superoxide Dismutase Up-regulation
[+]

Astaxanthin exhibits anti-inflammatory and anti-cancer activity in a rat model of colon cnacer.Apr 01, 2011

Pubmed Data : Invest New Drugs. 2011 Apr;29(2):207-24. Epub 2009 Oct 30. PMID: 19876598
Article Published Date : Apr 01, 2011
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Cancer Metastasis, Colon Cancer, Colorectal Cancer, Inflammation
Pharmacological Actions : Apoptotic, Chemopreventive, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Astaxanthin had an anti-depressant effect on diabetic mice.Dec 21, 2016

Pubmed Data : Brain Res. 2016 Dec 22. Epub 2016 Dec 22. PMID: 28017669
Article Published Date : Dec 21, 2016
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Brain Inflammation , Depression, Diabetic Complications
Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Prophylactic Agents
[+]

Barley sprouts have a protective effect against alcohol-induced liver injury.Jul 20, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2016 Jul 21 ;8(7). Epub 2016 Jul 21. PMID: 27455313
Article Published Date : Jul 20, 2016
Study Type : Animal Study
Additional Links
Substances : Barley
Diseases : Alcohol Toxicity , Chemically-Induced Liver Damage, Lipopolysaccharide-Induced Toxicity, Oxidative Stress
Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, Hepatoprotective
Additional Keywords : Plant Extracts
[+]

Benzyl isothiocyanate and sulforaphane protect against initiation of pancreatic carcinogenesis in hamsters.Sep 28, 2006

Pubmed Data : Cancer Lett. 2006 Sep 28;241(2):275-80. Epub 2006 Jan 4. PMID: 16386831
Article Published Date : Sep 28, 2006
Study Type : Animal Study
Additional Links
Substances : Benzyl isothiocyanate , Sulforaphane
Diseases : Pancreatic Cancer
Pharmacological Actions : Chemopreventive, Cyclooxygenase 2 Inhibitors
Additional Keywords : Isothiocyanates, Stilbenes
[+]

Berberine has a preventive effect on experimental colon cancer. Oct 01, 2010

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2010 Oct;35(20):2768-73. PMID: 21246838
Article Published Date : Oct 01, 2010
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Colon Cancer
Pharmacological Actions : Chemopreventive, Cyclooxygenase 2 Inhibitors
[+]

Boswellic acid suppresses growth and metastatis of human pancreatic tumors (nude mouse model). Jan 01, 2011

Pubmed Data : PLoS One. 2011 ;6(10):e26943. Epub 2011 Oct 31. PMID: 22066019
Article Published Date : Jan 01, 2011
Study Type : Transgenic Animal Study
Additional Links
Substances : Boswellia
Diseases : Cancer Metastasis, Pancreatic Cancer
Pharmacological Actions : Anti-metastatic, Apoptotic, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor Inhibitors
[+]

Both indole-3-carbinol and myo-inositol inhibit the development of vinyl carbamate induced pulmonary adenocarcinoma in mice.Jan 31, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Carcinogenesis. 2010 Feb ;31(2):239-45. Epub 2009 Jul 22. PMID: 19625346
Article Published Date : Jan 31, 2010
Study Type : Animal Study
Additional Links
Substances : Indole-3-Carbinol, Myo-inositol
Diseases : Lung Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors
Problem Substances : Vinyl Carbamate
[+]

C. obtusa essential oil may constitute a novel source of anti-inflammatory treatments. Jun 30, 2013

Pubmed Data : Mol Med Rep. 2013 Jul ;8(1):255-9. Epub 2013 May 8. PMID: 23652412
Article Published Date : Jun 30, 2013
Study Type : Animal Study
Additional Links
Substances : Japanese cypress
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Oils
[+]

Caffeic acid phenethyl ester, a compound found within propolis causes regression of experimental endometriosis.Apr 01, 2007

Pubmed Data : Reprod Sci. 2007 Apr;14(3):270-9. PMID: 17636241
Article Published Date : Apr 01, 2007
Study Type : Animal Study
Additional Links
Substances : Bee Propolis, Caffeic acid phenethyl ester
Diseases : Endometriosis
Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors
[+]

Carrot seeds contain phytochemicals capable of inhibiting inflammatory enzymes.Jun 01, 2007

Pubmed Data : Carcinogenesis. 2007 Jun;28(6):1188-96. Epub 2006 Dec 6. PMID: 13680840
Article Published Date : Jun 01, 2007
Study Type : Animal Study
Additional Links
Substances : Carrot
Pharmacological Actions : Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors
[+]

Chamaecyparis obtusa essential oil has anti-inflammatory and anti-nociceptive effects on arthritis in rats.Dec 31, 2014

Pubmed Data : Biosci Biotechnol Biochem. 2015 ;80(1):203-9. Epub 2015 Aug 19. PMID: 26581235
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Japanese cypress
Diseases : Arthritis
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Antinoceceptive , Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Essential Oils
[+]

Chinese skullcap (Scutellaria baicalensis) significantly improves functional recovery from spinal cord injury in rats by inhibiting inflammation and oxidative stress after injury.Aug 01, 2009

Pubmed Data : J Neurochem. 2009 Aug;110(4):1276-87. Epub 2009 Jun 10. PMID: 19519665
Article Published Date : Aug 01, 2009
Study Type : Animal Study
Additional Links
Substances : Chinese Skullcap
Diseases : Brain: Microglial Activation, Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Apoptotic, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Nitric Oxide Inhibitor
Additional Keywords : Plant Extracts
[+]

Cocoa may merit further clinical investigation as a chemopreventive agent that helps prevent colitis-associated cancer. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biofactors. 2015 Jan-Feb;41(1):1-14. Epub 2014 Dec 24. PMID: 25545372
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Cocoa
Diseases : Colorectal Cancer, Colorectal Cancer: Prevention , Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Nrf2 activation
[+]

Cocoa polyphenols may inhibit tumor promotion through antioxidant and antiinflammatory mechanisms.May 01, 2006

Pubmed Data : J Nutr. 2006 May;136(5):1150-5. PMID: 16614396
Article Published Date : May 01, 2006
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Polyphenols
Diseases : Tumors
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Crocetin supplementation in the MCA mice also showed protection against cervical cancer. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2015 ;2015:829513. Epub 2015 Mar 22. PMID: 25874230
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Cervical Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Crocin, a carotenoid fround within Gardenia jasminoides and Crocus sativus (Safron) has significant anti-inflammatory activity. Sep 23, 2009

Pubmed Data : J Agric Food Chem. 2009 Sep 23;57(18):8325-30. PMID: 19754168
Article Published Date : Sep 23, 2009
Study Type : Animal Study
Additional Links
Substances : Gardenia, Saffron
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors, Prostaglandin Antagonists
[+]

Curcumin ameliorates experimentally induced ulcerative colitis. Mar 01, 2007

Pubmed Data : Int Immunopharmacol. 2007 Mar;7(3):333-42. Epub 2006 Dec 18. PMID: 17276891
Article Published Date : Mar 01, 2007
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Colitis, Ulcerative Colitis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Curcumin attenuated glucose intolerance and insulin resistance through its antioxidant and anti-inflammatory effects.Dec 19, 2015

Pubmed Data : Chem Biol Interact. 2015 Dec 20. Epub 2015 Dec 20. PMID: 26713546
Article Published Date : Dec 19, 2015
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : C-Reactive Protein, Diabetes Mellitus: Type 2, Inflammation, Insulin Resistance, Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Curcumin can enhance postsynaptic electrical reactivity and cell viability in intact neural circuits with antidepressant-like effects.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mediators Inflamm. 2017 ;2017:6280925. Epub 2017 Jan 11. PMID: 28167853
Article Published Date : Dec 31, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Depression
Pharmacological Actions : Antidepressive Agents, Cyclooxygenase 2 Inhibitors
Additional Keywords : Antidepressive Agents, CURCUMIN, Cyclooxygenase 2 Inhibitors, depression
[+]

Curcumin has therapeutic effects in chemically-induced colitis. Jun 28, 2006

Pubmed Data : World J Gastroenterol. 2006 Jun 28;12(24):3848-53. PMID: 16804969
Article Published Date : Jun 28, 2006
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Colitis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Curcumin inhibits NF-kappaB activation and reduces the severity of experimental fatty liver in mice.Dec 01, 2003

Pubmed Data : Mech Ageing Dev. 2003 Dec;124(10-12):1025-34. PMID: 15582125
Article Published Date : Dec 01, 2003
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Fatty Liver
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Enzyme Inhibitors, Hepatoprotective, NF-kappaB Inhibitor
[+]

Curcumin inhibits prostate cancer tumors. Dec 01, 2009

Pubmed Data : Peptides. 2009 Dec;30(12):2357-64. Epub 2009 Sep 20. PMID: 19772879
Article Published Date : Dec 01, 2009
Study Type : Transgenic Animal Study
Additional Links
Substances : Curcumin
Diseases : Prostate Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]

Curcumin inhibits trinitrobenzene sulphonic acid-induced colitis in rats.Aug 01, 2006

Pubmed Data : Int Immunopharmacol. 2006 Aug;6(8):1233-42. Epub 2006 Apr 7. PMID: 16782535
Article Published Date : Aug 01, 2006
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Colitis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Prostaglandin PGE2 downregulation
[+]

Curcumin may have therapeutic value in colon cancer prevention.Oct 28, 1999

Pubmed Data : Oncogene. 1999 Oct 28;18(44):6013-20. PMID: 10557090
Article Published Date : Oct 28, 1999
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Colon Cancer
Pharmacological Actions : Antineoplastic Agents, Cyclooxygenase 2 Inhibitors, Enzyme Inhibitors, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Curcumin might be useful in the chemoprevention of colorectal cancer in individuals consuming an high-protein diet.Jul 31, 2015

Pubmed Data : Nutr Res. 2015 Aug ;35(8):726-35. Epub 2015 Jun 1. PMID: 26094212
Article Published Date : Jul 31, 2015
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Colorectal Cancer: Prevention , Gastrointestinal Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Curcumin potentiated significant increase in Nrf2 activation. It restored activity of phase-II antioxidant enzymes like GST, GR, NQO1, and tumour suppressor p53 level. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(4):e0124000. Epub 2015 Apr 10. PMID: 25860911
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Liver Cancer, Liver Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, MicroRNA modulator, Nrf2 activation, Tumor Suppressor Protein p53 Upregulation
[+]

Curcumin potentiates the antitumor effects of Bacillus Calmette-Guerin against bladder cancer.Dec 01, 2009

Pubmed Data : Cancer Res. 2009 Dec 1;69(23):8958-66. Epub 2009 Nov 10. PMID: 19903839
Article Published Date : Dec 01, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Bladder Cancer
Pharmacological Actions : Apoptotic, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Vascular Endothelial Growth Factor A Inhibitor
Additional Keywords : Drug Synergy
[+]

Curcumin prevents colon carcinogenesis. Apr 01, 1999

Pubmed Data : Carcinogenesis. 1999 Apr;20(4):641-4. PMID: 10223193
Article Published Date : Apr 01, 1999
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Colon Cancer, Colon Polyps
Pharmacological Actions : Anticarcinogenic Agents, Cyclooxygenase 2 Inhibitors, Enzyme Inhibitors, Nitric Oxide Inhibitor
[+]

Curcumin protects against necrotizing enterocolitis in neonatal rats.Feb 01, 2010

Pubmed Data : Zhongguo Dang Dai Er Ke Za Zhi. 2010 Feb;12(2):132-6. PMID: 20199731
Article Published Date : Feb 01, 2010
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Infant Infections, Necrotising enterocolitis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-10 downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Curcumin reduces oxidative and nitrative DNA damage associated with fluke infection.Oct 01, 2009

Pubmed Data : Mol Nutr Food Res. 2009 Oct;53(10):1316-28. PMID: 19753608
Article Published Date : Oct 01, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : DNA damage, Flukes, Oxidative Stress, Parasitic Diseases
Pharmacological Actions : Antimutagenic Agents, Antiparasitic Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Curcumin retards the growth of intestinal polyps in a mouse model of familial adenomatous polyposis.Feb 01, 2006

Pubmed Data : Eur J Cancer. 2006 Feb;42(3):415-21. Epub 2006 Jan 4. PMID: 16387490
Article Published Date : Feb 01, 2006
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Familial Adenomatous Polyposis, Intestinal Polyps
Pharmacological Actions : Chemopreventive, Cyclooxygenase 2 Inhibitors
[+]

Curcumin reverses neurochemical, histological and immuno-histochemical alterations in the model of global brain ischemia.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Tradit Complement Med. 2017 Jan ;7(1):14-23. Epub 2016 Feb 11. PMID: 28053883
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Brain Ischemia
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Curcumin works synergistically with paclitaxel to inhibit breast cancer cell metastasis to the lung in a mouse model. Oct 15, 2005

Pubmed Data : Clin Cancer Res. 2005 Oct 15;11(20):7490-8. PMID: 16243823
Article Published Date : Oct 15, 2005
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Breast Cancer, Breast Cancer: Lung Metastasis, Lung Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor, NF-kappaB Inhibitor
Additional Keywords : Drug: Paclitaxel, Drug-Plant-Vitamin Synergies
[+]

Cyanidin-3-O-glucoside exerts pulmonary protective effects on CLP-induced ALI rats. Jun 11, 2015

Pubmed Data : J Surg Res. 2015 Jun 12. Epub 2015 Jun 12. PMID: 26152793
Article Published Date : Jun 11, 2015
Study Type : Animal Study
Additional Links
Substances : Cyanidin 3-glucoside
Diseases : Lung Injury: Acute, Sepsis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Mitochondrial Superoxide Dismutase Upregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Demethoxycurcumin may decrease COX-2 expression and improve endothelial function in hypertension.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2016 ;2016:9045736. Epub 2016 Dec 25. PMID: 28105253
Article Published Date : Dec 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Demethoxycurcumin
Diseases : Endothelial Dysfunction, Hypertension
Pharmacological Actions : Cyclooxygenase 2 Inhibitors
[+]

Dendrosomal curcumin has a chemoprotective effect on the breast cancer metastasis through suppression of NF-κB and its regulated gene products.Jul 04, 2015

Pubmed Data : Eur J Pharmacol. 2015 Jul 5 ;758:188-96. Epub 2015 Apr 8. PMID: 25863259
Article Published Date : Jul 04, 2015
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Breast Cancer, Breast Cancer: Metastatic
Pharmacological Actions : Anti-metastatic, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor, Vascular Endothelial Growth Factor Inhibitors
[+]

Dietary administration of garcinol effectively reduced the tumor size and incidence in the mouse colon.Aug 31, 2014

Pubmed Data : Mol Nutr Food Res. 2014 Sep ;58(9):1820-9. Epub 2014 Jul 1. PMID: 24981158
Article Published Date : Aug 31, 2014
Study Type : Animal Study
Additional Links
Substances : Garcinia indica
Diseases : Colon Cancer, Colon Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Chemopreventive, Cyclin D1 Down-Regulation, Cyclooxygenase 2 Inhibitors, Vascular Endothelial Growth Factor Inhibitors
[+]

Dietary astaxanthin inhibits colitis and colitis-associated colon carcinogenesis in mice.May 20, 2011

Pubmed Data : Chem Biol Interact. 2011 May 20. Epub 2011 May 20. PMID: 21621527
Article Published Date : May 20, 2011
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Colitis, Colon Cancer
Pharmacological Actions : Chemopreventive, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor
[+]

Dietary feeding of grape seed extract prevents intestinal tumorigenesis in mice.Jan 01, 2010

Pubmed Data : Neoplasia. 2010 Jan;12(1):95-102. PMID: 20072658
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract
Diseases : Intestinal Cancer, Intestinal Polyps
Pharmacological Actions : Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors
[+]

Dietary flaxseed may be chemopreventive for intestinal and colon tumor development in mice possibly by increasing omega -3 fatty acid levels, lignans, and decreasing COX-1 and COX-2 levels.Jan 01, 2009

Pubmed Data : Nutr Cancer. 2009;61(2):276-83. PMID: 19235044
Article Published Date : Jan 01, 2009
Study Type : Animal Study
Additional Links
Substances : Flaxseed, Lignans, Omega-3 Fatty Acids
Diseases : Colon Cancer, Intestinal Cancer
Pharmacological Actions : Anticarcinogenic Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors
[+]

Dietary flaxseed meal containing high levels of omega-3 fatty acids and lignans is effective in preventing colon tumor development when compared with dietary corn meal possibly by increasing omega-3 fatty acid levels and decreasing COX-1 and COX-2 levels.Jan 01, 2006

Pubmed Data : Nutr Cancer. 2006;54(2):216-22. PMID: 16898866
Article Published Date : Jan 01, 2006
Study Type : Animal Study
Additional Links
Substances : Flaxseed, Lignans, Omega-3 Fatty Acids
Diseases : Colon Cancer
Pharmacological Actions : Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
[+]

Dietary intake of pterostilbene, a constituent of blueberries, inhibits colon carcinogenesis in rats.Jul 01, 2010

Pubmed Data : Carcinogenesis. 2010 Jul;31(7):1272-8. Epub 2010 Jan 8. PMID: 20061362
Article Published Date : Jul 01, 2010
Study Type : Animal Study
Additional Links
Substances : Blueberry, Pterostilbene
Diseases : Colon Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors
Additional Keywords : Stilbenes
[+]

Dietary saturated fatty acids down-regulate cyclooxygenase-2 and tumor necrosis factor alfa and reverse fibrosis in alcohol-induced liver disease in the rat.Dec 01, 1997

Pubmed Data : Hepatology. 1997 Dec;26(6):1538-45. PMID: 9397995
Article Published Date : Dec 01, 1997
Study Type : Animal Study
Additional Links
Substances : Medium Chain Triglycerides, Palm Oil, Saturated fatty acids
Diseases : Alcoholic Liver Disease, Liver Fibrosis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Beneficial Saturated Fats, Disease Reversal
[+]

Dietary supplementation of resveratrol attenuates chronic colonic inflammation in mice.Jan 01, 2010

Pubmed Data : Asia Pac J Clin Nutr. 2010;19(1):142-50. PMID: 20132809
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol, Stilbenes
Diseases : Inflammation, Ulcerative Colitis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Nitric Oxide Inhibitor, P38 Mitogen-Activated Protein Kinase Modulator, Prostaglandin E Synthase-1 (PGES-1) Down-Regulation
[+]

Electroacupuncture was an effective analgesic and anti-inflammatory.Oct 23, 2016

Pubmed Data : Chin J Integr Med. 2016 Oct 24. Epub 2016 Aug 24. PMID: 27778263
Article Published Date : Oct 23, 2016
Study Type : Animal Study
Additional Links
Diseases : Neuropathic Pain
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
[+]

Essential oils extracted from Chamaecyparis obtusa may be considered an effective therapeutic agent for the treatment of inflammatory diseases.Mar 31, 2016

Pubmed Data : Mol Med Rep. 2016 Apr ;13(4):3335-41. Epub 2016 Feb 18. PMID: 26936418
Article Published Date : Mar 31, 2016
Study Type : Animal Study
Additional Links
Substances : Japanese cypress
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Essential Oils
[+]

Evening primrose oil ameliorates platelet aggregation and improves cardiac recovery in myocardial-infarct hypercholesterolemic rats.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Physiol Pathophysiol Pharmacol. 2014 ;6(1):23-36. Epub 2014 Mar 13. PMID: 24665356
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Evening Primrose Oil
Diseases : Myocardial Infarction
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Extracts of R. officinalis and rosmarinic acid through modulating neuro-inflammation might be potential candidates in treating neuropathic pain.Dec 21, 2016

Pubmed Data : Biomed Pharmacother. 2016 Dec 22 ;86:441-449. Epub 2016 Dec 22. PMID: 28012923
Article Published Date : Dec 21, 2016
Study Type : Animal Study
Additional Links
Substances : Rosemary, Rosmarinic acid
Diseases : Brain Inflammation , Neuropathic Pain
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation
Additional Keywords : Plant Extracts
[+]

Fermented brown rice and rice bran have a chemopreventive effect on inflammation-related colorectal carcinogenesis in mice. Jan 01, 2010

Pubmed Data : Oncol Rep. 2010 Jan;23(1):53-9. PMID: 19956864
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Brown Rice, Fermented Foods and Beverages, Rice Bran
Diseases : Colorectal Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
[+]

Fisetin may be a potential agent in the treatment of osteoarthritis.Feb 13, 2017

Pubmed Data : Int Immunopharmacol. 2017 Feb 14 ;45:135-147. Epub 2017 Feb 14. PMID: 28213268
Article Published Date : Feb 13, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Fisetin
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Fucoidan exhibits a gastro-protective effect against aspirin-induced ulceration in rats.Jan 31, 2011

Pubmed Data : Int Immunopharmacol. 2011 Feb ;11(2):157-63. Epub 2010 Nov 26. PMID: 21084063
Article Published Date : Jan 31, 2011
Study Type : Animal Study
Additional Links
Substances : Fucoidan
Diseases : Aspirin-Induced Toxicity , Gastric Ulcer
Pharmacological Actions : Anti-Ulcer Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Epidermal growth factor receptor (EGFR) inhibitor
Problem Substances : Aspirin
Adverse Pharmacological Actions : Ulcerogenic
[+]

Fucoxanthin may have therapeutic potential as a treatment for patients with inflammatory diseases.Sep 28, 2015

Pubmed Data : J Biochem Mol Toxicol. 2015 Sep 29. Epub 2015 Sep 29. PMID: 26418808
Article Published Date : Sep 28, 2015
Study Type : Animal Study
Additional Links
Substances : Fucoxanthin
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Geraniol could be a powerful treatment of intestinal inflammation and dysbiosis.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2016 ;7:38. Epub 2016 Mar 3. PMID: 26973525
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Geraniol
Diseases : Colitis, Dysbiosis, Gastrointestinal Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
[+]

Ginger inhibits micoglial cell activiation associated with brain inflammation. Jun 01, 2009

Pubmed Data : Food Chem Toxicol. 2009 Jun;47(6):1190-7. Epub 2009 Feb 20. PMID: 19233241
Article Published Date : Jun 01, 2009
Study Type : Animal Study
Additional Links
Substances : Ginger
Diseases : Brain: Microglial Activation, Brain Inflammation , Inflammation, Lipopolysaccharide-Induced Toxicity, Neurodegenerative Diseases
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Prostaglandin Antagonists
[+]

Gingerol could protect against experimental liver fibrosis in rats.Jan 25, 2016

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2016 Jan 26. Epub 2016 Jan 26. PMID: 26809353
Article Published Date : Jan 25, 2016
Study Type : Animal Study
Additional Links
Substances : Gingerol
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Ginkgo biloba extract anti-inflammatory properties and ameliorates colitis in mice. Sep 01, 2008

Pubmed Data : Carcinogenesis. 2008 Sep;29(9):1799-806. Epub 2008 Jun 20. PMID: 18567620
Article Published Date : Sep 01, 2008
Study Type : Animal Study
Additional Links
Substances : Ginkgo biloba
Diseases : Colitis, Inflammation
Pharmacological Actions : Antioxidants, Apoptotic, Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts
[+]

Ginkgo biloba extract protects against aging-associated mitochondrial dysfunction in platelets and hippocampi of mice.Jan 01, 2010

Pubmed Data : Platelets. 2010;21(5):373-9. PMID: 20459350
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Ginkgo biloba
Diseases : Aging, Aging: Brain , Mitochondrial Dysfunction
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

Ginsenosides from the leaves of Panax quinquefolius ameliorated acetaminophen-induced hepatotoxicity in mice.May 09, 2017

Pubmed Data : J Agric Food Chem. 2017 May 10 ;65(18):3684-3692. Epub 2017 Apr 25. PMID: 28429935
Article Published Date : May 09, 2017
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective, Malondialdehyde Down-regulation
Problem Substances : Acetaminophen, Paracetamol
[+]

Graviola possesses analgesic effects through interaction with opioidergic pathway and anti-inflammatory properties through inhibition of chemical mediators of inflammation.Nov 30, 2014

Pubmed Data : J Med Food. 2014 Dec ;17(12):1375-82. PMID: 25133801
Article Published Date : Nov 30, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Graviola
Diseases : Arthritis, Rheumatism
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
Additional Keywords : Natural Substances Versus Drugs
Problem Substances : Carrageenan
[+]

Hops (H. lupulus) has anti-inflammatory activity in a mouse model of athritis. Jul 16, 1996

Pubmed Data : Biochem Biophys Res Commun. 1996 Jul 16;224(2):358-61. PMID: 16534727
Article Published Date : Jul 16, 1996
Study Type : Animal Study
Additional Links
Substances : Hops
Diseases : Arthritis, Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation
Additional Keywords : Plant Extracts
[+]

Korean Red Ginseng extracts exhibited anti-inflammatory effects by ameliorating the symptoms of gastric ulcer in a gastritis mouse model.Sep 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Ginseng Res. 2016 Oct ;40(4):437-444. Epub 2016 Aug 24. PMID: 27746698
Article Published Date : Sep 30, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginseng (Korean)
Diseases : Gastric Ulcer, Gastritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Gastrointestinal Agents, Gastroprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

LED therapy provides an analgesic effect and modifies the expression of COX-2, PGE2, and proinflammatory cytokines in incised skin.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pain Res Manag. 2017 ;2017:4792489. Epub 2017 Apr 2. PMID: 28469528
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Diseases : Wound Healing
Therapeutic Actions : Light-Emitting Diodes (LEDs) Therapy
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation
[+]

Lion's mane has antitumor effects in tumor-bearing mice.Sep 28, 2011

Pubmed Data : J Agric Food Chem. 2011 Sep 28 ;59(18):9861-9. Epub 2011 Aug 25. PMID: 21846141
Article Published Date : Sep 28, 2011
Study Type : Animal Study
Additional Links
Substances : Lion's Mane (Hericium Erinaceus)
Diseases : Colon Cancer, Low Immune Function: Natural Killer Cells, Tumors
Pharmacological Actions : 5-Lipoxygenase Inhibitor, Anti-Angiogenic, Antineoplastic Agents, Cyclooxygenase 2 Inhibitors, Vascular Endothelial Growth Factor Inhibitors
[+]

Lupeol acetate significantly improves the symptoms of RA by down-regulating expressions of inflammatory cytokines and osteoclastogenesis.Mar 31, 2016

Pubmed Data : Biomed Pharmacother. 2016 Apr ;79:231-40. Epub 2016 Mar 11. PMID: 27044833
Article Published Date : Mar 31, 2016
Study Type : Animal Study
Additional Links
Substances : Lupeol
Diseases : Arthritis, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Dose Response
[+]

L‑carnitine ameliorated liver inflammation and serum pro‑inflammatory markers in cancer cachexia.Dec 03, 2015

Pubmed Data : Mol Med Rep. 2015 Dec 4. Epub 2015 Dec 4. PMID: 26647854
Article Published Date : Dec 03, 2015
Study Type : Animal Study
Additional Links
Substances : L-Carnitine
Diseases : Cachexia: Cancer, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

M. oleifera containing Vicenin-2 active compound may accelerate wound healing in hyperglycemic conditions.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2016 ;10:1715-30. Epub 2016 May 24. PMID: 27307703
Article Published Date : Dec 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Moringa oleifera
Diseases : Diabetic Complications, Wound Healing: Delayed
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Melatonin and pycnogenol have a therapeutic role in the treatment fo endothelial dysfunction.Aug 01, 2003

Pubmed Data : Int J Mol Med. 2003 Aug;12(2):269-73. PMID: 20421515
Article Published Date : Aug 01, 2003
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Melatonin
Diseases : Endothelial Dysfunction, Hypertension
Pharmacological Actions : Antihypertensive Agents, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]

Melatonin causes regression and atrophy of the endometriotic lesions in rats.Apr 01, 2008

Pubmed Data : Fertil Steril. 2008 Apr;89(4):934-42. Epub 2007 Jun 19. PMID: 17582405
Article Published Date : Apr 01, 2008
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Endometriosis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors
[+]

Morinda citrifolia leaf was more effective than the erlotinib in suppressing lung adenocarcinoma in mice. Jan 13, 2016

Pubmed Data : Food Funct. 2016 Jan 14. Epub 2016 Jan 14. PMID: 26765787
Article Published Date : Jan 13, 2016
Study Type : Animal Study
Additional Links
Substances : Noni, Noni leaf extract
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer
Pharmacological Actions : Antiproliferative , Cyclooxygenase 2 Inhibitors, Epidermal growth factor receptor (EGFR) inhibitor, Immunomodulatory
Additional Keywords : Dose Response, Superiority of Natural Substances versus Drugs
[+]

Mulberry fruit suppressed the development of intestinal inflammation and tumorgenesis both in vitro and in vivo.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2015 ;5:17348. Epub 2015 Nov 30. PMID: 26615818
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Mulberry
Diseases : Colitis, Colorectal Cancer: Prevention , Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Myricetin has protective cardiovascular effects against ischemia/reperfusion-induced myocardial injury.Aug 01, 2016

Pubmed Data : Cardiovasc Toxicol. 2016 Aug 2. Epub 2016 Aug 2. PMID: 27484498
Article Published Date : Aug 01, 2016
Study Type : Animal Study
Additional Links
Substances : Myricetin
Diseases : Myocardial Ischemia
Pharmacological Actions : Antioxidants, Cardioprotective, Cyclooxygenase 2 Inhibitors, Malondialdehyde Down-regulation
[+]

Nobiletin restored intestinal barrier function, which had been damaged after TNBS administration, through the inhibition of the Akt-NF-κB-MLCK pathway.Apr 30, 2015

Pubmed Data : Mol Nutr Food Res. 2015 May ;59(5):829-42. Epub 2015 Mar 16. PMID: 25655748
Article Published Date : Apr 30, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Citrus Peel , Nobiletin
Diseases : Colitis, Inflammation, Intestinal Permeability
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
[+]

Noni, and its major bioactive component damnacanthal, exhibits anti-inflammatory properties. Nov 01, 2011

Pubmed Data : Inflamm Allergy Drug Targets. 2011 Nov 1. Epub 2011 Nov 1. PMID: 21999179
Article Published Date : Nov 01, 2011
Study Type : Animal Study
Additional Links
Substances : Damnacanthal, Noni
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Nitric Oxide Inhibitor
[+]

Nutmeg oil alleviates chronic inflammatory pain through inhibition of COX-2 expression.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Nutr Res. 2016 ;60:30849. Epub 2016 Apr 26. PMID: 27121041
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Nutmeg
Diseases : Allodynia, Chronic Pain, Inflammation
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
Additional Keywords : Superiority of Natural Substances versus Drugs
Problem Substances : Diclofenac
[+]

Oligonol ameliorates carbon tetrachloride induced liver injury in rats. Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2016 ;2016:3935841. Epub 2015 Dec 21. PMID: 26798422
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Lychee
Diseases : Chemically-Induced Liver Damage, Lipid Peroxidation
Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, Hepatoprotective, Interleukin-1 beta downregulation, Malondialdehyde Down-regulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Oligonol is effective in protecting against DSS-induced mouse colitis and colon carcinogenesis.Jul 09, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxid Redox Signal. 2013 Jul 10 ;19(2):102-14. Epub 2013 May 15. PMID: 23394584
Article Published Date : Jul 09, 2013
Study Type : Animal Study
Additional Links
Substances : Lychee
Diseases : Colitis, Colon Cancer, Inflammation, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Anticarcinogenic Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Colitis, COLON CANCER, Inflammation, Lipid Peroxidation, Lychee, oxidative stress
[+]

Oral administration of black ginger extract significantly prevents UVB-induced photoaging in hairless mice.Sep 30, 2014

Pubmed Data : Photodermatol Photoimmunol Photomed. 2014 Oct ;30(5):237-45. Epub 2014 Jan 9. PMID: 24313661
Article Published Date : Sep 30, 2014
Study Type : Animal Study
Additional Links
Substances : Kaempferia parviflora
Diseases : Aging Skin, Ultraviolet Radiation Induced Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Catalase Up-Regulation, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor, Photoprotective
Additional Keywords : Plant Extracts
[+]

Oral curcumin may have chemopreventive properties against colorectal cancer. Feb 01, 2001

Pubmed Data : Cancer Res. 2001 Feb 1;61(3):1058-64. PMID: 11221833
Article Published Date : Feb 01, 2001
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Colorectal Cancer
Pharmacological Actions : Anticarcinogenic Agents, Cyclooxygenase 2 Inhibitors
[+]

Oral feeding of pomegranate fruit extract inhibits early biomarkers of UVB radiation-induced carcinogenesis. Nov 01, 2010

Pubmed Data : Photochem Photobiol. 2010 Nov-Dec;86(6):1318-26. Epub 2010 Oct 14. PMID: 20946358
Article Published Date : Nov 01, 2010
Study Type : Animal Study
Additional Links
Substances : Pomegranate
Diseases : Lipid Peroxidation, Skin Cancer: Prevention
Therapeutic Actions : Sunlight exposure
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts
[+]

Oral tangeretin treatment effectively reduced the tumor cell proliferation markers and suppressed metastasis. Oct 31, 2014

Pubmed Data : J Nutr Biochem. 2014 Nov ;25(11):1140-53. Epub 2014 Aug 1. PMID: 25151216
Article Published Date : Oct 31, 2014
Study Type : Animal Study
Additional Links
Substances : Tangeretin
Diseases : Breast Cancer, Breast Cancer: Metastatic
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Chemotherapeutic, Cyclooxygenase 2 Inhibitors, Nitric Oxide Inhibitor
[+]

Perilla frutescens and rosmarinic acid may play a role in ameliorating allergy diseases.Jan 01, 2011

Pubmed Data : Exp Biol Med (Maywood). 2011 Jan;236(1):99-106. PMID: 21239739
Article Published Date : Jan 01, 2011
Study Type : Animal Study
Additional Links
Substances : Perilla , Rosmarinic acid
Diseases : Allergic Rhinitis, Allergic Rhinoconjunctivitis
Pharmacological Actions : Anti-Allergic Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor
Additional Keywords : Plant Extracts
[+]

Phloretin inhibits phorbol ester-induced tumor promotion and expression of cyclooxygenase-2 in mouse skin.Feb 29, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Med Food. 2012 Mar ;15(3):253-7. Epub 2011 Dec 19. PMID: 22181070
Article Published Date : Feb 29, 2012
Study Type : Animal Study
Additional Links
Substances : Phloretin
Diseases : Skin Cancer
Pharmacological Actions : Anticarcinogenic Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
Additional Keywords : Anticarcinogenic Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Phloretin, skin cancer
[+]

Pine need extract is anti-inflammatory and has a protective effect on cholesteorl oxidation. Jan 01, 2008

Pubmed Data : Food Chem Toxicol. 2008 Jan;46(1):175-85. Epub 2007 Jul 28. PMID: 17804140
Article Published Date : Jan 01, 2008
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Pine Needle, Polyphenols
Diseases : Cholesterol: Oxidation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, Enzyme Inhibitors
[+]

Plant-derived oil rich in ALA could ameliorate the inflammatory damage in colitis.Aug 13, 2015

Pubmed Data : J Nutr Biochem. 2015 Aug 14. Epub 2015 Aug 14. PMID: 26350254
Article Published Date : Aug 13, 2015
Study Type : Animal Study
Additional Links
Substances : ALA (Alpha-Linolenic Acid)
Diseases : Colitis, Inflammatory Bowel Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Pomegranate extract is abundant in hydrolysable tannins that display multiple anti-acne capacities.Jan 11, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2017 Jan 12 ;18(1). Epub 2017 Jan 12. PMID: 28085116
Article Published Date : Jan 11, 2017
Study Type : Animal Study
Additional Links
Substances : Pomegranate
Diseases : Acne
Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation
Additional Keywords : Plant Extracts
[+]

Punicalagin inhibits lipopolysaccharide induced memory impairment via anti-inflammatory and anti-amylogenic mechanisms.Jan 25, 2017

Pubmed Data : Neuropharmacology. 2017 Jan 26 ;117:21-32. Epub 2017 Jan 26. PMID: 28132781
Article Published Date : Jan 25, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Brain Inflammation , Lipopolysaccharide-Induced Toxicity, Memory Disorders
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Punicalagin protected rat livers against cyclophosphamide toxicity.Jun 30, 2016

Pubmed Data : Environ Toxicol Pharmacol. 2016 Jul ;45:158-62. Epub 2016 Aug 1. PMID: 27310207
Article Published Date : Jun 30, 2016
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Hepatoprotective
[+]

Purple sweet potato induces antioxidant defense via the Nrf2 pathway and reduces inflammation via NF-κB inhibition in DMN-induced liver injury.Dec 31, 2010

Pubmed Data : Food Chem Toxicol. 2011 Jan ;49(1):93-9. Epub 2010 Oct 8. PMID: 20934476
Article Published Date : Dec 31, 2010
Study Type : Animal Study
Additional Links
Substances : Anthocyanins, Sweet Potato: Purple
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective, NF-kappaB Inhibitor, Nrf2 activation
[+]

Purple sweet potato may be useful for mitigating inflammatory brain diseases by the inhibition of proinflammatory molecule production.Jan 31, 2010

Pubmed Data : Neurochem Int. 2010 Feb ;56(3):424-30. Epub 2009 Nov 24. PMID: 19941923
Article Published Date : Jan 31, 2010
Study Type : Animal Study
Additional Links
Substances : Sweet Potato: Purple
Diseases : Brain Inflammation , Lipopolysaccharide-Induced Toxicity, Memory Disorders
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Quercitrin attenuates acetaminophen induced liver damage by the activation of defensive genes and the inhibition of pro-inflammatory genes.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2016 ;8(7). Epub 2016 Jul 15. PMID: 27428996
Article Published Date : Dec 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Toona sinensis
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, NF-E2-Related Factor-2 (Nrf2) Modulator
Problem Substances : Acetaminophen, Paracetamol
[+]

Red light modulates ultraviolet-induced gene expression in the epidermis of hairless mice.Sep 30, 2015

Pubmed Data : Photomed Laser Surg. 2015 Oct ;33(10):498-503. Epub 2015 Sep 23. PMID: 26398729
Article Published Date : Sep 30, 2015
Study Type : Animal Study
Additional Links
Diseases : Ultraviolet Radiation Induced Damage
Therapeutic Actions : Light-Emitting Diodes (LEDs) Therapy
Pharmacological Actions : Cyclooxygenase 2 Inhibitors
Additional Keywords : Gene Expression Regulation
[+]

Red wine and black tea and polyphenolic extracts modulate COX-2, iNOS and GSH-related gene expression in tumors, suggesting also a possible chemotherapeutic activity of these compounds.May 31, 2002

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Nutr. 2002 Jun ;132(6):1376-9. PMID: 12042461
Article Published Date : May 31, 2002
Study Type : Animal Study
Additional Links
Substances : Black Tea, Polyphenols, Red Wine
Diseases : Colon Cancer, Colon Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Chemotherapeutic, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors, Enzyme Inhibitors, Nitric Oxide Inhibitor
Additional Keywords : Gene Expression Regulation
[+]

Resveratrol has anti-inflammatory and chemopreventive properties in an animal model of liver cancer. Jun 01, 2010

Pubmed Data : Pharm Res. 2010 Jun;27(6):1080-91. Epub 2010 Apr 20. PMID: 20405173
Article Published Date : Jun 01, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Inflammation, Liver Cancer
Pharmacological Actions : Anticarcinogenic Agents, Cyclooxygenase 2 Inhibitors, Heat Shock Protein Inducer, NF-kappaB Inhibitor
Additional Keywords : Stilbenes
[+]

Resveratrol has anti-inflammatory and neuroprotective properties in experimental diabetic neuropathy.Apr 02, 2010

Pubmed Data : Biochem Biophys Res Commun. 2010 Apr 2;394(2):360-5. Epub 2010 Mar 6. PMID: 20211601
Article Published Date : Apr 02, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol, Stilbenes
Diseases : Diabetic Neuropathy, Oxidative Stress
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Neuroprotective Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Resveratrol inhibits proinflammatory cytokine (IL-8) production in monocytic cells. Jan 01, 2009

Pubmed Data : Am J Chin Med. 2009;37(6):1203-14. PMID: 19938227
Article Published Date : Jan 01, 2009
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Inflammation
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Immunomodulatory, Interleukin-8 downregulation, NF-kappaB Inhibitor
[+]

Resveratrol may protect against colitis through up-regulation of SIRT1 in immune cells in the colon.Mar 01, 2010

Pubmed Data : J Pharmacol Exp Ther. 2010 Mar;332(3):829-39. Epub 2009 Nov 25. PMID: 19940103
Article Published Date : Mar 01, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol, Stilbenes
Diseases : Colitis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, SIRT1 Activator
[+]

Rosmarinic acid has an ameliorative effect on colonic inflammation and thus a potential therapeutic role in colitis.Apr 05, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Apr 6 ;7:46252. Epub 2017 Apr 6. PMID: 28383063
Article Published Date : Apr 05, 2017
Study Type : Animal Study
Additional Links
Substances : Rosmarinic acid
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-22 Downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, STAT3 Inhibitor
[+]

Royal jelly showed anti-inflammatory and antioxidant properties in experimental colitisDec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : ScientificWorldJournal. 2015 ;2015:956235. Epub 2015 Mar 2. PMID: 25821860
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Royal Jelly
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Ruta graveolens extract had anti-inflammatory and antioxidant activity, with potent inhibitory effects on the arachidonic acid pathways.Feb 28, 2014

Pubmed Data : Chin J Nat Med. 2014 Mar ;12(3):172-9. PMID: 24702802
Article Published Date : Feb 28, 2014
Study Type : Animal Study
Additional Links
Substances : Ruta Graveolens
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Rutin exhibits significant physiological, biochemical and immunological protection against Methotrexate induced intestinal toxicity.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2016 ;16:99. Epub 2016 Mar 10. PMID: 26965456
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Rutin
Diseases : Drug-Induced Toxicity: Methotrexate
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
[+]

Saturated fatty acids, palm oil and medium chain triglycerides, reverse inflammatory and fibrotic changes in rat liver despite continued ethanol administration.Nov 01, 2001

Pubmed Data : J Pharmacol Exp Ther. 2001 Nov;299(2):638-44. PMID: 11602676
Article Published Date : Nov 01, 2001
Study Type : Animal Study
Additional Links
Substances : Medium Chain Triglycerides, Palm Oil, Saturated fatty acids
Diseases : Alcoholic Liver Disease
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Beneficial Saturated Fats
[+]

Sesamol suppresses cyclooxygenase-2 transcriptional activity in colon cancer cells.Feb 28, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Biochem Nutr. 2014 Mar ;54(2):95-101. Epub 2014 Feb 19. PMID: 24688218
Article Published Date : Feb 28, 2014
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Colon Cancer
Pharmacological Actions : Chemopreventive, Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation
[+]

Silibinin inhibits lung tumor angiogenesis in an animal model.Jun 20, 2006

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Natl Cancer Inst. 2006 Jun 21 ;98(12):846-55. PMID: 16788158
Article Published Date : Jun 20, 2006
Study Type : Animal Study
Additional Links
Substances : Silibinin
Diseases : Inflammation, Lung Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors, Vascular Endothelial Growth Factor Inhibitors
[+]

Sour cherry juice has antioxidant and anti-inflammatory activity. Dec 01, 2009

Pubmed Data : Plant Foods Hum Nutr. 2009 Dec;64(4):231-7. PMID: 19763832
Article Published Date : Dec 01, 2009
Study Type : Animal Study
Additional Links
Substances : Sour Cherry
Diseases : Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts
[+]

Sulforaphane exhibits chemopreventive properties against intestinal polyps in mice.Dec 01, 2006

Pubmed Data : Biopharm Drug Dispos. 2006 Dec;27(9):407-20. PMID: 16952200
Article Published Date : Dec 01, 2006
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Adenomatous Polyposis Coli, Intestinal Polyps
Pharmacological Actions : Anticarcinogenic Agents, Cyclooxygenase 2 Inhibitors
[+]

Sulforaphane may be a potential a candidate for use in the treatment of acute lung injury.Dec 31, 2015

Pubmed Data : Int J Mol Med. 2016 Jan ;37(1):182-8. Epub 2015 Oct 27. PMID: 26531002
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-E2-Related Factor-2 (Nrf2) Modulator, Prostaglandin PGE2 downregulation
[+]

Supplementation with probiotics was able to reduce tumor incidence, tumor multiplicity and average tumor size.Apr 30, 2015

Pubmed Data : Nutr Cancer. 2015 May-Jun;67(4):603-11. Epub 2015 Mar 26. PMID: 25811420
Article Published Date : Apr 30, 2015
Study Type : Animal Study
Additional Links
Substances : Lactobacillus rhamnosus , Probiotics
Diseases : Colon Cancer, Colon Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Cyclooxygenase 2 Inhibitors
Additional Keywords : Supplementation
[+]

The flower extract of Rosa rugosa may be a beneficial anti-inflammatory agent.Feb 29, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomol Ther (Seoul). 2016 Mar 1 ;24(2):184-90. PMID: 26797110
Article Published Date : Feb 29, 2016
Study Type : Animal Study
Additional Links
Substances : Rose
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

The present study concluded that Spirulina is able to restrain the changes produced through adjuvant-induced arthritis.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(4):e0121523. Epub 2015 Apr 8. PMID: 25853428
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Spirulina
Diseases : Arthritis
Pharmacological Actions : Anti-Angiogenic, Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Vascular Endothelial Growth Factor Inhibitors
[+]

These findings confirm the chemopreventive potential of chrysin against benzo(a)pyrene induced lung cancer in Swiss albino mice.Mar 31, 2016

Pubmed Data : Pharmacol Rep. 2016 Apr ;68(2):310-8. Epub 2015 Sep 6. PMID: 26922533
Article Published Date : Mar 31, 2016
Study Type : Animal Study
Additional Links
Substances : Chrysin
Diseases : Lung Cancer, Lung Cancer: Prevention
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
Problem Substances : Benzo(a)pyrene
[+]

These findings confirmed the anti-inflammatory effects of resveratrol and quercetin in BLM-induced lung damage.Aug 31, 2015

Pubmed Data : Br J Nutr. 2015 Sep ;114(6):853-865. PMID: 26334388
Article Published Date : Aug 31, 2015
Study Type : Animal Study
Additional Links
Substances : Mangiferin, Quercetin, Resveratrol
Diseases : Pulmonary Fibrosis, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
[+]

These findings strongly suggest that the anti-inflammatory actions of Thymoquinone are caused by suppression of IRAK-linked AP-1/NF-κB pathways.Feb 19, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Feb 20 ;7:42995. Epub 2017 Feb 20. PMID: 28216638
Article Published Date : Feb 19, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Thymoquinone
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Inflammation, Interleukin-1 beta downregulation, thymoquinone
[+]

These findings suggest that shikonin has therapeutic potential for osteoarthritis.Sep 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2016 Oct ;12(4):2735-2740. Epub 2016 Aug 31. PMID: 27703516
Article Published Date : Sep 30, 2016
Study Type : Animal Study
Additional Links
Substances : Shikonin
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These results indicate that shikonin treatment may prevent the loss of vision associated with diabetic retinopathy.Mar 20, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Mar 21 ;7:44985. Epub 2017 Mar 21. PMID: 28322323
Article Published Date : Mar 20, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Shikonin
Diseases : Diabetic Retinopathy
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
Additional Keywords : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Diabetic Retinopathy, Shikonin
[+]

These results indicate the potential antidiabetic benefits of M. oleifera ethanolic leaf extract.May 02, 2017

Pubmed Data : J Med Food. 2017 May 3. Epub 2017 May 3. PMID: 28467233
Article Published Date : May 02, 2017
Study Type : Animal Study
Additional Links
Substances : Moringa oleifera
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, Hypoglycemic Agents, Hypolipidemic, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Renoprotective
Additional Keywords : Plant Extracts
[+]

These results provide powerful evidence for the chemopreventive efficacy of Chrysin against chemically induced renal carcinogenesis.Jul 08, 2016

Pubmed Data : Arch Biochem Biophys. 2016 Jul 9. Epub 2016 Jul 9. PMID: 27403965
Article Published Date : Jul 08, 2016
Study Type : Animal Study
Additional Links
Substances : Chrysin
Diseases : Kidney Cancer, Kidney Cancer: Prevention
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Antioxidants, Apoptotic, Bcl-2 protein down-regulation, Chemopreventive, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These results provide scientific evidence for the use of E. longifolia as a potential analgesic and anti-inflammatory agent.Feb 29, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arch Pharm Res. 2016 Mar ;39(3):421-8. Epub 2016 Jan 30. PMID: 26832325
Article Published Date : Feb 29, 2016
Study Type : Animal Study
Additional Links
Substances : Tongkat Ali
Diseases : Inflammation
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
Additional Keywords : Dose Response, Superiority of Natural Substances versus Drugs
Problem Substances : Diclofenac
[+]

This study demonstrated the anti-arthritic, anti-inflammatory, anti-oxidative stress and chondro-protective potentials of sesamol in vivo. Sep 30, 2013

Pubmed Data : Eur J Nutr. 2013 Oct ;52(7):1787-99. Epub 2012 Dec 27. PMID: 23269651
Article Published Date : Sep 30, 2013
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Arthritis, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chondroprotective, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

This study indicates that a methanol extract from Inonotus obliquus has anti-inflammatory and anti-nociceptive properties.Oct 02, 2005

Pubmed Data : J Ethnopharmacol. 2005 Oct 3 ;101(1-3):120-8. PMID: 15905055
Article Published Date : Oct 02, 2005
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Chaga Mushroom (Inonotus obliquus)
Diseases : Inflammation
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Antinoceceptive , Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Thymol mitigates lipopolysaccharide-induced endometritis.Mar 20, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Mar 21 ;8(12):20042-20055. PMID: 28223539
Article Published Date : Mar 20, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Thymol
Diseases : Endometritis, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Thymoquinone abolishes a number of factors known to be involved in rheumatoid arthritis pathogenesis.Dec 31, 2010

Pubmed Data : J Cell Biochem. 2011 Jan ;112(1):107-17. PMID: 20872780
Article Published Date : Dec 31, 2010
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Inflammation, Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Anti-Inflammatory Agents, Antiproliferative, Inflammation, rheumatoid arthritis, thymoquinone
[+]

Thymoquinone augmented the chemopreventive effect of vitamin D during the initiation phase of colon cancer.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2017 ;9(2):774-790. Epub 2017 Feb 15. PMID: 28337306
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Thymoquinone, Vitamin D
Diseases : Colon Cancer
Pharmacological Actions : Chemopreventive, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Natural Substance Synergy
[+]

Thymoquinone could confer intestinal protection against methotrexate induced mucositis.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacogn Mag. 2016 Jan ;12(Suppl 1):S76-81. PMID: 27041864
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Drug Toxicity: Methotrexate
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Apoptotic, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Thymoquinone inhibits LoVo cancer cell growth and migration.Feb 20, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2017 Feb 21 ;23(7):1171-1179. PMID: 28275297
Article Published Date : Feb 20, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Thymoquinone
Diseases : Colon Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Antiproliferative , Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation
Additional Keywords : Dose Response
[+]

Tormentic acid may be a potential therapeutic candidate for the prevention of acetaminophen induced liver injury.May 17, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2017 May 18 ;22(5). Epub 2017 May 18. PMID: 28524081
Article Published Date : May 17, 2017
Study Type : Animal Study
Additional Links
Substances : Loquat
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Acetaminophen, Paracetamol
[+]

Treatment with taraxasterol significantly increased the pain thresholds and reduced the clinical arthritic scores of mice.Nov 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2016 Dec ;12(6):4035-4040. Epub 2016 Nov 2. PMID: 28101182
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Substances : Dandelion
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Vitamin C has protective effects against spinal cord injury-induced kidney damage.Mar 31, 2015

Pubmed Data : Neurol Sci. 2015 Apr ;36(4):521-6. Epub 2014 Nov 18. PMID: 25403314
Article Published Date : Mar 31, 2015
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Vitamin D3 and 5-FU synergise together and exhibit better anticancer effects by modulating Wnt/β-catenin pathway.Jul 24, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Exp Clin Cancer Res. 2015 Jul 25 ;34:71. Epub 2015 Jul 25. PMID: 26205949
Article Published Date : Jul 24, 2015
Study Type : Animal Study
Additional Links
Substances : Vitamin D
Diseases : Colon Cancer
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Heat Shock Protein Down-Regulation, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Walnuts reduced prostate tumor growth by affecting energy metabolism along with decreased plasma IGF-1 and cholesterol.Nov 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Med Food. 2014 Dec ;17(12):1281-6. PMID: 25354213
Article Published Date : Nov 30, 2014
Study Type : Transgenic Animal Study
Additional Links
Substances : Walnut
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative , Chemopreventive, Cyclooxygenase 2 Inhibitors
Additional Keywords : Dietary Concentrations
[+]

Wogonin and 5-fluorouracil combination treatment caused a significant growth inhibition of human tumor xenografts in vivo.Jul 31, 2013

Pubmed Data : Biochem Cell Biol. 2013 Aug ;91(4):221-9. Epub 2013 Feb 14. PMID: 23859016
Article Published Date : Jul 31, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Chemosensitizer, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors
Additional Keywords : Drug: 5-flourouracil, Natural Substance/Drug Synergy, Plant Extracts
[+]

Wogonin prevents alcohol-induced gastric mucosal damage in rats. Aug 01, 2008

Pubmed Data : Appl Environ Microbiol. 2008 Aug;74(15):4650-5. Epub 2008 Jun 6. PMID: 15139485
Article Published Date : Aug 01, 2008
Study Type : Animal Study
Additional Links
Substances : Wogonin
Diseases : Alcohol Toxicity
Pharmacological Actions : Apoptotic, Cyclooxygenase 2 Inhibitors
[+]

Zerumbone possesses anti-inflammatory and antinociceptive effects.Feb 17, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2016 Feb 18 ;17(2):249. Epub 2016 Feb 18. PMID: 26901193
Article Published Date : Feb 17, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Zerumbone
Diseases : Arthritis, Lipopolysaccharide-Induced Toxicity, Osteoarthritis
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor
[+]

Zerumbone reduced the inflammatory response of acute lung injury in endotoxin-treated mice.Apr 21, 2017

Pubmed Data : Chem Biol Interact. 2017 Apr 22 ;271:9-14. Epub 2017 Apr 22. PMID: 28442377
Article Published Date : Apr 21, 2017
Study Type : Animal Study
Additional Links
Substances : Zerumbone
Diseases : Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

α-solanine may be a promising therapeutic against inflammatory diseases by inhibiting the NF-κB signaling pathway.Mar 01, 2016

Pubmed Data : J Cell Biochem. 2016 Mar 2. Epub 2016 Mar 2. PMID: 26931732
Article Published Date : Mar 01, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Potato
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Sepsis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

β-patchoulene isolated from patchouli oil had Anti-inflammatory activity.Apr 13, 2016

Pubmed Data : Eur J Pharmacol. 2016 Apr 14. Epub 2016 Apr 14. PMID: 27090925
Article Published Date : Apr 13, 2016
Study Type : Animal Study
Additional Links
Substances : Patchouli
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Dose Response, Plant Oils
[+]

ω-3 polyunsaturated fatty acids had inhibitory effects on endometrial cancer development.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2015;5:14958. Epub 2015 Oct 15. PMID: 26468779
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Endometrial Cancer
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation
Additional Keywords : Risk Reduction
[+]

"Anti-inflammatory effects of fucoidan through inhibition of NF-κB, MAPK and Akt activation in lipopolysaccharide-induced BV2 microglia cells."Jul 31, 2011

Pubmed Data : Food Chem Toxicol. 2011 Aug ;49(8):1745-52. Epub 2011 May 4. PMID: 21570441
Article Published Date : Jul 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Fucoidan
Diseases : Brain: Microglial Activation, Brain Inflammation , Lipopolysaccharide-Induced Toxicity, Neurodegenerative Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

"Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells."Jul 31, 2012

Pubmed Data : J Pineal Res. 2012 Aug ;53(1):77-90. Epub 2012 Feb 16. PMID: 22335196
Article Published Date : Jul 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Melatonin
Diseases : Breast Cancer
Pharmacological Actions : Antioxidants, Antiproliferative , Apaf-1/caspase-dependent apoptotic pathway activator, Apoptotic, Cyclooxygenase 2 Inhibitors, p300/NF-κB down-regulation, PI3K/Akt/signaling suppression
[+]

18β-Glycyrrhetinic acid may be used as a chemopreventive agent in liver cancer.Apr 25, 2016

Pubmed Data : Mol Cell Biochem. 2016 Apr 26. Epub 2016 Apr 26. PMID: 27116616
Article Published Date : Apr 25, 2016
Study Type : In Vitro Study
Additional Links
Substances : 18β-Glycyrrhetinic Acid
Diseases : Liver Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Apoptotic, Chemopreventive, Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

A guava leaf extract contains potential therapeutic agents, which regulate NF-κB activation, for the treatment of inflammatory conditions.Oct 31, 2015

Pubmed Data : Fish Shellfish Immunol. 2015 Nov ;47(1):85-92. Epub 2015 Aug 29. PMID: 26327113
Article Published Date : Oct 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Guava
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-10 downregulation, Interleukin-1 beta downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Dose Response, Plant Extracts
[+]

A hexane fraction of P. vulgaris var. lilacina may be a potent anti-inflammatory candidate.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2013 ;14(11):21489-503. Epub 2013 Oct 30. PMID: 24177568
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Prunella vulgaris.
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Prostaglandin PGE2 downregulation
Additional Keywords : Plant Extracts
[+]

A wogonin-rich-fraction of Scutellaria baicalensis root extract exerts chondroprotective effects.Mar 02, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Mar 3 ;7:43789. Epub 2017 Mar 3. PMID: 28256567
Article Published Date : Mar 02, 2017
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Chondroprotective, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Achillea fragrantissima possesses anti-neuroinflammatory activities for prevention or treatment of neurodegenerative diseases.Dec 31, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2011 ;11:98. Epub 2011 Oct 21. PMID: 22018032
Article Published Date : Dec 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Achillea fragrantissima
Diseases : Brain: Microglial Activation, Brain Inflammation , Neurodegenerative Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Matrix metalloproteinase-9 (MMP-9) inhibitor, Neuroprotective Agents, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

American Ginseng inhibits induced COX-2 and NFKB activation in breast cancer cells.Dec 01, 2009

Pubmed Data : J Surg Res. 2009 Dec;157(2):261-7. Epub 2009 Jun 6. PMID: 19815237
Article Published Date : Dec 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Ginseng (American)
Diseases : Breast Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
Additional Keywords : Plant Extracts
[+]

An extract of Lotus may be a powerful agent against colon cancer cells.Feb 28, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2017 Mar ;13(3):1470-1478. Epub 2016 Dec 28. PMID: 28454279
Article Published Date : Feb 28, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor
Additional Keywords : Apoptotic, Bcl-2 protein down-regulation, COLON CANCER, Lotus, Plant Extracts
[+]

Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis.Feb 14, 2013

Pubmed Data : Phytomedicine. 2013 Feb 15 ;20(3-4):328-36. Epub 2012 Dec 6. PMID: 23219337
Article Published Date : Feb 14, 2013
Study Type : In Vitro Study
Additional Links
Substances : Chinese Skullcap , Wogonin
Diseases : Osteosarcoma
Pharmacological Actions : Anti-metastatic, Cyclooxygenase 2 Inhibitors, VEGFR3 inhibition
Additional Keywords : Phytotherapy
[+]

Antioxidants have been shown to significantly influence cell growth, DNA repair and mitochondrial membrane-mediated apoptosis.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2014 ;15(9):16226-45. Epub 2014 Sep 15. PMID: 25226533
Article Published Date : Dec 31, 2013
Study Type : Review
Additional Links
Substances : Flavonoids, Ginsenosides, Polyphenols, Ursolic Acid
Diseases : Cancers: All, DNA damage, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Antioxidants, Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors, DNA Repair Up-regulation
Additional Keywords : Gene Expression Regulation
[+]

Aromatic-turmerone attenuates invasion and expression of MMP-9 and COX-2 through inhibition of NF-κB activation in TPA-induced breast cancer cells.Nov 30, 2012

Pubmed Data : J Cell Biochem. 2012 Dec ;113(12):3653-62. PMID: 22740037
Article Published Date : Nov 30, 2012
Study Type : In Vitro Study
Additional Links
Substances : Turmerones
Diseases : Breast Cancer
Pharmacological Actions : Anti-metastatic, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor
[+]

Artemisinin may be a potentially useful therapeutic agent for inflammatory-related diseases.Jan 31, 2017

Pubmed Data : Immunopharmacol Immunotoxicol. 2017 Feb ;39(1):28-36. Epub 2016 Dec 21. PMID: 28000518
Article Published Date : Jan 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Artemisinin
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Dose Response
[+]

Artesunate markedly inhibited gastric cancer cell proliferation in a time and dose dependent manner and induced apoptosis in gastric cancer cells a dose dependent manner.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Onco Targets Ther. 2015 ;8:845-54. Epub 2015 Apr 16. PMID: 25945055
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Artesunate, Wormwood
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors
Additional Keywords : Dose Response
[+]

Arthrocen could potentially bring about the reduced pain produced by COX‐2 inhibitors without the known side effects of COX‐2 inhibition.Jan 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : FEBS Open Bio. 2017 Feb ;7(2):187-194. Epub 2017 Jan 9. PMID: 28174685
Article Published Date : Jan 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Avacado
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation
[+]

Astaxanthin attenuates the UVB-induced secretion of prostaglandin E(2) and interleukin-8, indicating its possible role in minimizing inflammation associated with skin damage.Jul 01, 2012

Pubmed Data : Exp Dermatol. 2012 Jul ;21 Suppl 1:11-7. PMID: 22626465
Article Published Date : Jul 01, 2012
Study Type : In Vitro Study
Additional Links
Substances : Astaxanthin
Diseases : Skin Diseases: Photo-Aging, Sunburn
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-8 downregulation, Prostaglandin PGE2 downregulation
[+]

Avocado soybean unsaponifiables and epigallocatechin gallate reduce inflammation in chondrocytes. Dec 01, 2004

Pubmed Data : J Chem Neuroanat. 2004 Dec;28(4):253-64. PMID: 19748608
Article Published Date : Dec 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Avocado, EGCG (Epigallocatechin gallate), Soy, Unsaponifiables
Diseases : Osteoarthritis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Prostaglandin Antagonists
[+]

Bamboo extracts exhibited anti-inflammatory properties by inhibiting NF-κB-induced gene expression.Jan 31, 2014

Pubmed Data : Phytother Res. 2014 Feb ;28(2):224-30. Epub 2013 Apr 5. PMID: 23559516
Article Published Date : Jan 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Bamboo
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
Additional Keywords : Plant Extracts
[+]

Bee venom and its major component melittin reduce proinflammatory mediators in lipopolysaccharide-stimulated microglia.Jan 01, 2010

Pubmed Data : Nutr Cancer. 2010;62(2):148-53. PMID: 17570326
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Bee Venom
Diseases : Brain: Microglial Activation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, NF-kappaB Inhibitor
[+]

Betulinic acid inhibits hepatitis C virus replication by suppressing the NF-κB- and ERK1/2-mediated COX-2 pathway.Jun 22, 2015

Pubmed Data : Br J Pharmacol. 2015 Jun 23. Epub 2015 Jun 23. PMID: 26102077
Article Published Date : Jun 22, 2015
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Hepatitis C
Pharmacological Actions : Anti-Inflammatory Agents, Antiviral Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Black rice whole grain extracts exhibits therapeutic potential associated with the anthocyanin content in the extract for treating inflammatory diseases associated with cancer.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(10):4277-83. PMID: 26028086
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Rice: Black
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Dose Response
[+]

Bromelain has anti-tumor initiating activity against skin cancer cells.Sep 18, 2009

Pubmed Data : Cancer Lett. 2009 Sep 18;282(2):167-76. Epub 2009 Mar 31. PMID: 19339108
Article Published Date : Sep 18, 2009
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Skin Cancer
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Bcl-2 protein down-regulation, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation
[+]

Bromelain inhibits lipopolysaccharide-induced inflammation. Jan 01, 2003

Pubmed Data : J Huazhong Univ Sci Technolog Med Sci. 2003;23(2):151-3. PMID: 18569070
Article Published Date : Jan 01, 2003
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Bromelain may have anti-skin tumor activity. Jan 01, 2008

Pubmed Data : Toxicol Appl Pharmacol. 2008 Jan 1;226(1):30-7. Epub 2007 Aug 23. PMID: 17889918
Article Published Date : Jan 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Skin Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Bcl-2 protein down-regulation, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation
[+]

Butterbur (P. hybridus) exhibits ant-inflammatory activity in rat microglial (brain) cells. Jan 01, 2005

Pubmed Data : Planta Med. 2005 Jan;71(1):12-9. PMID: 15678367
Article Published Date : Jan 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Butterbur
Diseases : Brain: Microglial Activation, Brain Inflammation , Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors, Postaglandin PGE2 downregulation
Additional Keywords : Plant Extracts
[+]

C. obtusa f.formnosana wood oil had very good anti-inflammatory efficacies.Apr 30, 2014

Pubmed Data : Nat Prod Commun. 2014 May ;9(5):723-6. PMID: 25026733
Article Published Date : Apr 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Japanese cypress
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Oils
[+]

Cannabidiolic acid abrogates the expression of COX-2 via the selective down-regulation of c-fos.Aug 15, 2016

Pubmed Data : J Nat Med. 2016 Aug 16. Epub 2016 Aug 16. PMID: 27530354
Article Published Date : Aug 15, 2016
Study Type : In Vitro Study
Additional Links
Substances : Cannabis
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Cyclooxygenase 2 Inhibitors
[+]

Cannabidiolic acid had dual inhibitory effects on COX-2 through down-regulation and enzyme inhibition, and may suppress genes that are positively involved in the metastasis of cancer cells in vitro.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Toxicol Sci. 2014 ;39(5):711-6. PMID: 25242400
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Cannabis
Diseases : Breast Cancer, Breast Cancer: Metastatic, Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Cyclooxygenase 2 Inhibitors, Enzyme Inhibitors
Additional Keywords : Gene Expression Regulation
[+]

Cannabinoids may have a role to play in arthritis prevention and treatment. Feb 28, 2006

Pubmed Data : J Pharm Pharmacol. 2006 Mar ;58(3):351-8. PMID: 16536902
Article Published Date : Feb 28, 2006
Study Type : Review
Additional Links
Substances : Cannabinoids
Diseases : Arthritis
Pharmacological Actions : Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
[+]

Capsaicin is a novel chemopreventive molecule.Jan 01, 2010

Pubmed Data : Indian J Cancer. 2010 Jan-Mar;47(1):53-8. PMID: 20071791
Article Published Date : Jan 01, 2010
Study Type : Commentary
Additional Links
Substances : Capsaicin
Diseases : Cancers: All
Pharmacological Actions : Apoptotic, Cell cycle arrest, Chemopreventive, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Celecoxib and curcumin work synergistically to inhibit the growth of colorectal cancer cells.Sep 15, 2005

Pubmed Data : Clin Cancer Res. 2005 Sep 15;11(18):6738-44. PMID: 16166455
Article Published Date : Sep 15, 2005
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Colon Cancer, Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors, Prostaglandin PGE2 downregulation
Additional Keywords : Drug: Celecoxib, Drug Synergy
[+]

Chamomile is a novel and selective COX-2 inhibitor with anti-inflammatory activity.Nov 04, 2009

Pubmed Data : Life Sci. 2009 Nov 4;85(19-20):663-9. Epub 2009 Sep 27. PMID: 19788894
Article Published Date : Nov 04, 2009
Study Type : In Vitro Study
Additional Links
Substances : Apigenin, Chamomile
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Cyclooxygenase 2 Inhibitors
Additional Keywords : Natural Substances Versus Drugs, Plant Extracts
[+]

Chrysin suppresses lipopolysaccharide-induced inflammation.Jan 31, 2005

Pubmed Data : FEBS Lett. 2005 Jan 31;579(3):705-11. PMID: 15670832
Article Published Date : Jan 31, 2005
Study Type : In Vitro Study
Additional Links
Substances : Chrysin, Flavonoids
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation
[+]

Clinical studies have reported that oral fish oil supplementation has beneficial effects in rheumatoid arthritis and among some asthmatics, supporting the idea that the n-3 FA in fish oil are anti-inflammatoryMar 31, 2003

Pubmed Data : Lipids. 2003 Apr ;38(4):343-52. PMID: 12848278
Article Published Date : Mar 31, 2003
Study Type : Review
Additional Links
Substances : Omega-3 Fatty Acids
Diseases : Asthma, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors
[+]

Combined exosome-melatonin regimen was superior to either alone in protecting the liver against ischemia-reperfusion injury.Dec 31, 2016

Pubmed Data : Am J Transl Res. 2017 ;9(4):1543-1560. Epub 2017 Apr 15. PMID: 28469765
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Melatonin
Diseases : Liver Injury: Ischemia/reperfusion
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Matrix metalloproteinase-9 (MMP-9) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Exosomes
[+]

Constituents of Asparagus officinalis have anti-inflammatory activity against the Cox-2 enzyme. Apr 21, 2004

Pubmed Data : J Agric Food Chem. 2004 Apr 21;52(8):2218-22. PMID: 15080623
Article Published Date : Apr 21, 2004
Study Type : In Vitro Study
Additional Links
Substances : Asparagus
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
[+]

CoQ10 may have therapeutic potential for neurodegenerative diseases by inhibiting pro-inflammatory mediators production.Apr 26, 2017

Pubmed Data : Brain Res Bull. 2017 Apr 27 ;131:192-198. Epub 2017 Apr 27. PMID: 28458038
Article Published Date : Apr 26, 2017
Study Type : In Vitro Study
Additional Links
Substances : Coenzyme Q10
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation
[+]

Cross-linked bromelain inhibits lipopolysaccharide-induced inflammation. Mar 22, 2006

Pubmed Data : J Agric Food Chem. 2006 Mar 22;54(6):2193-8. PMID: 16536595
Article Published Date : Mar 22, 2006
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
[+]

Cucurbitacin B possesses immunomodulatory and anti-inflammatory effects.Dec 31, 2014

Pubmed Data : Immunopharmacol Immunotoxicol. 2015 ;37(5):473-80. PMID: 26466646
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Cucurbitacin B
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Immunomodulatory, Interleukin-12 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Cumin essential oil exerted anti-inflammatory effects in LPS-stimulated RAW 264.7 cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:474509. Epub 2015 Sep 6. PMID: 26425131
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Cumin
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
Additional Keywords : Dose Response, Essential Oils
[+]

Curcumin and catechin works synergistically to inhibit rat colon carcinogensis. Jan 01, 2005

Pubmed Data : Di Yi Jun Yi Da Xue Xue Bao. 2005 Jan;25(1):48-52. PMID: 15683997
Article Published Date : Jan 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Catechin , Curcumin
Diseases : Colon Cancer
Pharmacological Actions : Cyclooxygenase 2 Inhibitors
Additional Keywords : Natural Substance Synergy
[+]

Curcumin and resveratrol compare favorably with NSAID agents in inhibiting inflammatory processes associated with tumor cell proliferation.Dec 09, 2004

Pubmed Data : Oncogene. 2004 Dec 9;23(57):9247-58. PMID: 15489888
Article Published Date : Dec 09, 2004
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Resveratrol
Diseases : Tumors
Pharmacological Actions : Antiproliferative , Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Natural Substances Versus Drugs, Superiority of Natural Substances versus Drugs
[+]

Curcumin attenuates the release of pro-inflammatory cytokines in lipopolysaccharide-stimulated BV2 microglia.Oct 01, 2007

Pubmed Data : Acta Pharmacol Sin. 2007 Oct;28(10):1645-51. PMID: 17883952
Article Published Date : Oct 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Brain: Microglial Activation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Curcumin augments gemcitabine cytotoxic effect on pancreatic cancer cell lines.Sep 01, 2007

Pubmed Data : Cancer Invest. 2007 Sep;25(6):411-8. PMID: 17882652
Article Published Date : Sep 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Pancreatic Cancer
Pharmacological Actions : Apoptotic, Chemosensitizer, Cyclooxygenase 2 Inhibitors
Additional Keywords : Drug: Gemcitabine, Drug Synergy
[+]

Curcumin displays therapeutic activity in experimental studies of acute and chronic diseases characterized by an exaggerated inflammatory reaction. Feb 01, 1978

Pubmed Data : Horm Behav. 1978 Feb;10(1):54-60. PMID: 16387899
Article Published Date : Feb 01, 1978
Study Type : Review
Additional Links
Substances : Curcumin
Diseases : Inflammation
Pharmacological Actions : Antineoplastic Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Enzyme Inhibitors
[+]

Curcumin down-regulates cancer-associated NF-kappab B activation and Cox-2 expression in precancerous and cancerous oral cells.Nov 10, 2006

Pubmed Data : Toxicology. 2006 Nov 10;228(1):1-15. Epub 2006 Aug 12. PMID: 16996673
Article Published Date : Nov 10, 2006
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Oral Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Chemopreventive, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Curcumin downregulates the constitutive activity of NF-kappaB and induces programmed cell death in novel mouse melanoma cells.Oct 01, 2007

Pubmed Data : Melanoma Res. 2007 Oct;17(5):274-83. PMID: 17885582
Article Published Date : Oct 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Melanoma
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Curcumin enhances the effects of 5-fluorouracil and oxaliplatin (FOLFOX) in mediating growth inhibition of colon cancer cells.Jan 15, 2008

Pubmed Data : Int J Cancer. 2008 Jan 15;122(2):267-73. PMID: 17918158
Article Published Date : Jan 15, 2008
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Colorectal Cancer
Pharmacological Actions : Apoptotic, Cyclooxygenase 2 Inhibitors, Insulin-Like Growth Factor Inhibition/Downregulation
Additional Keywords : Drug: 5-flourouracil, Drug-Plant-Vitamin Synergies
[+]

Curcumin exhibits anti-cancer activity against promyelocytic leukemia and submandibular cancer cells.Nov 01, 2005

Pubmed Data : Anticancer Res. 2005 Nov-Dec;25(6B):4029-36. PMID: 16309195
Article Published Date : Nov 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Promyelocytic leukemia , Submandibular Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Cyclooxygenase 2 Inhibitors
[+]

Curcumin exhibits anti-cancer, anti-inflammatory and antioxidant activities.Jul 01, 2000

Pubmed Data : Phytomedicine. 2000 Jul;7(4):303-8. PMID: 10969724
Article Published Date : Jul 01, 2000
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Breast Cancer, Colon Cancer, Kidney Cancer, Melanoma
Pharmacological Actions : Antioxidants, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors
[+]

Curcumin exhibits cytotoxic activity against Giardia lamblia trophozoites. Jan 01, 1990

Pubmed Data : Biomed Pharmacother. 1990;44(10):511-4. PMID: 16678799
Article Published Date : Jan 01, 1990
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Giardiasis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Enzyme Inhibitors, NF-kappaB Inhibitor
[+]

Curcumin has anti-pancreatic and lung cancer activity.Nov 01, 2006

Pubmed Data : Anticancer Res. 2006 Nov-Dec;26(6B):4423-30. PMID: 17201164
Article Published Date : Nov 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Lung Cancer, Pancreatic Cancer
Pharmacological Actions : Apoptotic, Cyclooxygenase 2 Inhibitors, Epidermal growth factor receptor (EGFR) inhibitor
[+]

Curcumin has been demonstrated to be safe in six human trials and has demonstrated anti-inflammatory activity.Feb 01, 2003

Pubmed Data : J Altern Complement Med. 2003 Feb;9(1):161-8. PMID: 12676044
Article Published Date : Feb 01, 2003
Study Type : Review
Additional Links
Substances : Curcumin
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antineoplastic Agents, Cyclooxygenase 2 Inhibitors, Lipoxygenase Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Curcumin has chemopreventive properties in nicotine-induced proliferation and angiogenesis in llung cancer cells.Jan 01, 2010

Pubmed Data : Mol Cancer. 2010;9:220. Epub 2010 Aug 20. PMID: 20727180
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Lung Cancer, Nicotine/Tobacco Toxicity
Pharmacological Actions : Anti-Angiogenic, Antiproliferative , Chemopreventive, Cyclooxygenase 2 Inhibitors, Tumor Suppressor Protein p53 Upregulation
[+]

Curcumin has chemoprotective effects in esophageal epithelial cells exposed to bile acids.Sep 07, 2010

Pubmed Data : World J Gastroenterol. 2010 Sep 7;16(33):4152-8. PMID: 20806431
Article Published Date : Sep 07, 2010
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Esophageal Cancer
Pharmacological Actions : Antiproliferative , Chemopreventive, Cyclooxygenase 2 Inhibitors
[+]

Curcumin has nutritional potential as a naturally occurring anti-inflammatory agent for treating osteoarthritis. May 01, 2007

Pubmed Data : Biochem Pharmacol. 2007 May 1;73(9):1434-45. Epub 2007 Jan 7. PMID: 17291458
Article Published Date : May 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Osteoarthritis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor, NF-kappaB Inhibitor
[+]

Curcumin induces programmed cell death in leukemia cells. May 01, 2008

Pubmed Data : Carcinogenesis. 2008 May;29(5):1042-8. Epub 2008 Mar 13. PMID: 11756235
Article Published Date : May 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Acute T cell Leukemias, Promyelocytic leukemia
Pharmacological Actions : Apoptotic, Cyclooxygenase 2 Inhibitors
[+]

Curcumin inhibits cell migration of human colon cancer cells.Mar 01, 2006

Pubmed Data : Anticancer Res. 2006 Mar-Apr;26(2A):1281-8. PMID: 16619535
Article Published Date : Mar 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cancer Metastasis, Colon Cancer
Pharmacological Actions : Antineoplastic Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]

Curcumin inhibits cyclooxygenase and matrix metalloproteinase-8 expression associated with breast cancer progrression.Nov 01, 2005

Pubmed Data : Antioxid Redox Signal. 2005 Nov-Dec;7(11-12):1612-20. PMID: 16356124
Article Published Date : Nov 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Breast Cancer
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor
[+]

Curcumin inhibits cyclooxygenase-2 expression in human colon cancer cells. Oct 30, 2001

Pubmed Data : Cancer Lett. 2001 Oct 30;172(2):111-8. PMID: 11566484
Article Published Date : Oct 30, 2001
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Colon Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Chemopreventive, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors
[+]

Curcumin inhibits inflammatory processes associated with skin cancer promotion. Sep 01, 2003

Pubmed Data : Carcinogenesis. 2003 Sep;24(9):1515-24. Epub 2003 Jul 4. PMID: 12844482
Article Published Date : Sep 01, 2003
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Skin Cancer
Pharmacological Actions : Anticarcinogenic Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Curcumin inhibits interferon-alpha induced NF-kappaB and COX-2 in human non-small cell lung cancer cells.Aug 26, 2005

Pubmed Data : Biochem Biophys Res Commun. 2005 Aug 26;334(2):313-8. PMID: 16005433
Article Published Date : Aug 26, 2005
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Curcumin inhibits lipopolysaccharide-induced inflammation. Jul 01, 2010

Pubmed Data : Int Immunopharmacol. 2010 Jul;10(7):760-8. Epub 2010 Apr 22. PMID: 20399909
Article Published Date : Jul 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation
[+]

Curcumin inhibits liver tumor angiogenesis and growth. Jan 01, 2006

Pubmed Data : Clin Hemorheol Microcirc. 2006;34(1-2):109-15. PMID: 16543625
Article Published Date : Jan 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cancer Metastasis, Liver Cancer
Pharmacological Actions : Anti-Angiogenic, Cyclooxygenase 2 Inhibitors, Vascular Endothelial Growth Factor A Inhibitor
[+]

Curcumin inhibits the proliferation of colonic cancer cells.Sep 01, 2009

Pubmed Data : Zhonghua Nei Ke Za Zhi. 2009 Sep;48(9):760-3. PMID: 20079215
Article Published Date : Sep 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors
[+]

Curcumin may be applied as an effective and novel sunscreen drug for the protection of photoinflammation.Jun 30, 2005

Pubmed Data : Exp Mol Med. 2005 Jun 30;37(3):186-92. PMID: 16000872
Article Published Date : Jun 30, 2005
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Sunburn
Therapeutic Actions : Sunlight exposure
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Enzyme Inhibitors
Additional Keywords : Topical Sunscreen
[+]

Curcumin may be effective for the prevention of severe lower respiratory tract disease in infants and young children.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2013 ;8(9):e70225. Epub 2013 Sep 18. PMID: 24058438
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Respiratory Syncytial Virus Infections
Pharmacological Actions : Antiviral Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Proteasome Inhibitors
[+]

Curcumin may have anti-tumor properties in cervical cancer. Sep 23, 2008

Pubmed Data : Phytother Res. 2008 Sep 23. PMID: 19058955
Article Published Date : Sep 23, 2008
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Cyclooxygenase 2 Inhibitors
[+]

Curcumin may protect against amyloid-beta-stimulated inflammation associated wtih Alzheimer disease.Jan 01, 2010

Pubmed Data : J Alzheimers Dis. 2010;20(4):1189-99. PMID: 20413894
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Alzheimer's Disease, Brain Inflammation , Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Neuroprotective Agents
[+]

Curcumin potently induces programmed cell death in colon cancer cellsJun 01, 2005

Pubmed Data : Br J Nutr. 2005 Jun;93(6):835-44. PMID: 19723094
Article Published Date : Jun 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Colon Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest, Cyclooxygenase 2 Inhibitors
[+]

Curcumin prevents chemically-induced inflammation in gastrointestinal lines associated with cancer promotion.Feb 01, 2009

Pubmed Data : J Invest Dermatol. 2009 Feb;129(2):468-75. Epub 2008 Aug 14. PMID: 10190560
Article Published Date : Feb 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cancers: All, Gastrointestinal Cancer, Inflammation
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors
[+]

Curcumin reduces inflammation and carcinogensis associated with arachidonic acid metabolism. Jul 01, 2009

Pubmed Data : J Nutr. 2009 Jul;139(7):1273-8. Epub 2009 May 20. PMID: 15073046
Article Published Date : Jul 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Colon Cancer, Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Antineoplastic Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Enzyme Inhibitors
[+]

Curcumin suppresses cigarette smoke-induced promotion of human non-small cell lung cancer cell growth.Jul 01, 2003

Pubmed Data : Carcinogenesis. 2003 Jul;24(7):1269-79. Epub 2003 May 9. PMID: 12807725
Article Published Date : Jul 01, 2003
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer, Smoking
Pharmacological Actions : Antineoplastic Agents, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor, NF-kappaB Inhibitor
[+]

Curcumin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression associated with inflammation.Mar 01, 2004

Pubmed Data : J Pharmacol Sci. 2004 Mar;94(3):325-8. PMID: 15037818
Article Published Date : Mar 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Brain: Microglial Activation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Curcumin suppresses the inflammatory response of brain microglial cells.Dec 01, 2003

Pubmed Data : J Immunol. 2003 Dec 1;171(11):6072-9. PMID: 14634121
Article Published Date : Dec 01, 2003
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Brain: Microglial Activation, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
[+]

Curcumin synergistically potentiates the anti-cancer effects of celecoxib in pancreatic cancer cells.Oct 01, 2005

Pubmed Data : Biomed Pharmacother. 2005 Oct;59 Suppl 2:S276-80. PMID: 16507392
Article Published Date : Oct 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Pancreatic Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Chemosensitizer, Cyclooxygenase 2 Inhibitors
Additional Keywords : Drug Synergy
[+]

Curcumin works synergistically with celecoxib to potentiate a growth-inhibitory and pro-apoptotic in osteoarthritis synovial adherent cells.Feb 01, 2006

Pubmed Data : Rheumatology (Oxford). 2006 Feb;45(2):171-7. Epub 2005 Oct 25. PMID: 16249246
Article Published Date : Feb 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Osteoarthritis: Knee, Oxidative Stress
Pharmacological Actions : Antioxidants, Antiproliferative , Apoptotic, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
Additional Keywords : Drug: Celecoxib, Drug Synergy
[+]

Curcumin's ability to inhibit VEGF-mediated angiogenesis in human intestinal microvascular endothelial cells indicate it may have value in irritable bowel syndrome and cancer.Nov 01, 2008

Pubmed Data : Gut. 2008 Nov;57(11):1509-17. Epub 2008 Jul 2. PMID: 18596194
Article Published Date : Nov 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cancers: All, Irritable Bowel Syndrome
Pharmacological Actions : Anti-Angiogenic, Cyclooxygenase 2 Inhibitors, Vascular Endothelial Growth Factor A Inhibitor
[+]

Curcumin, EGCG and resveratrol inhibit inflammation.Sep 01, 2001

Pubmed Data : Mutat Res. 2001 Sep 1;480-481:243-68. PMID: 11506818
Article Published Date : Sep 01, 2001
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, EGCG (Epigallocatechin gallate), Resveratrol
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Cyanidin has anti-aging properties under a stress-induced premature senescence cellular system.Jan 01, 2010

Pubmed Data : Biol Pharm Bull. 2010;33(3):421-6. PMID: 20190403
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Cyanidin
Diseases : Aging, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
Additional Keywords : Plant Extracts
[+]

Dandelion (Taraxacum officinale) has anti-angiogenic, anti-inflammatory and anti-nociceptive (pain-killing) activities.May 01, 2008

Pubmed Data : Int J Oncol. 2008 May;32(5):1085-90. PMID: 17949929
Article Published Date : May 01, 2008
Study Type : Review
Additional Links
Substances : Dandelion
Diseases : Inflammation
Pharmacological Actions : Analgesics, Anti-Angiogenic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
[+]

Dandelion contains compounds with antioxidant and anti-inflammatory properties. Oct 01, 2004

Pubmed Data : Mol Cell Biochem. 2004 Oct;265(1-2):107-13. PMID: 15543940
Article Published Date : Oct 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Dandelion
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Oxidative Stress
Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors
Additional Keywords : Plant Extracts
[+]

Dandelion leaves have an anti-inflammatory effect on lipopolysaccharide-induced inflammation. Aug 01, 2010

Pubmed Data : J Med Food. 2010 Aug;13(4):870-8. PMID: 20673058
Article Published Date : Aug 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Dandelion
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation
Additional Keywords : Plant Extracts
[+]

Desoxo-narchinol-A isolated from Nardostachys jatamansi exhibits protective effects against LPS-induced endotoxin shock and inflammation.Nov 30, 2015

Pubmed Data : Int Immunopharmacol. 2015 Dec ;29(2):730-8. Epub 2015 Sep 11. PMID: 26371857
Article Published Date : Nov 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Spikenard
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Echinacea inhibit cyclooxygenase-2 activity in human neuroglioma cells.Aug 24, 2007

Pubmed Data : Biochem Biophys Res Commun. 2007 Aug 24;360(2):441-6. Epub 2007 Jun 19. PMID: 17599805
Article Published Date : Aug 24, 2007
Study Type : In Vitro Study
Additional Links
Substances : Echinacea
Diseases : Inflammation
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation
Additional Keywords : Plant Extracts
[+]

Ellagic acid inhibits the proliferation of human pancreatic carcinoma PANC-1 cells.Jan 24, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Jan 25. Epub 2017 Jan 25. PMID: 28135203
Article Published Date : Jan 24, 2017
Study Type : In Vitro Study
Additional Links
Substances : Ellagic Acid
Diseases : Pancreatic Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
Additional Keywords : Dose Response
[+]

Epinephrine stimulates esophageal squamous-cell carcinoma cell proliferation.Sep 01, 2008

Pubmed Data : J Cell Biochem. 2008 Sep 1 ;105(1):53-60. PMID: 18452159
Article Published Date : Sep 01, 2008
Study Type : In Vitro Study
Additional Links
Diseases : Cancers: Drug Resistant, Esophageal Cancer, Squamous cell carcinoma
Pharmacological Actions : Antiproliferative , Cyclooxygenase 2 Inhibitors, Vascular Endothelial Growth Factor A Inhibitor
Anti Therapeutic Actions : Stress
Problem Substances : Adrenaline
Adverse Pharmacological Actions : Chemoresistance upregulation
[+]

Evaluation of antimicrobial and anti-inflammatory activities of seed extracts from six Nigella species.Mar 31, 2009

Pubmed Data : J Med Food. 2009 Apr ;12(2):408-15. PMID: 19459745
Article Published Date : Mar 31, 2009
Study Type : In Vitro Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Bacterial Infections, Inflammation
Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Antifungal Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts
[+]

Extracts of the fruits of Maqui-berry may provide a potential therapeutic approach for inflammation associated disorders.Dec 27, 2016

Pubmed Data : Food Chem Toxicol. 2016 Dec 28. Epub 2016 Dec 28. PMID: 28040469
Article Published Date : Dec 27, 2016
Study Type : In Vitro Study
Additional Links
Substances : Maqui
Diseases : Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors
Additional Keywords : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Inflammation, Maqui, oxidative stress, Plant Extracts
[+]

Ferulic acid could reduce the oxidative stress induced by hypoxia in PC12 cells.Apr 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2015 May ;18(5):478-84. PMID: 26124934
Article Published Date : Apr 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Ferulic acid
Diseases : Brain Hypoxia, Oxidative Stress
Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, Neuroprotective Agents, Superoxide Dismutase Up-regulation
[+]

Feverfew contains the compound parthenolide which has a chemopreventive action against UVB-induced skin caner. Aug 01, 2004

Pubmed Data : Carcinogenesis. 2004 Aug;25(8):1449-58. Epub 2004 Mar 19. PMID: 15033901
Article Published Date : Aug 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Feverfew
Diseases : Skin Cancer
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Cyclooxygenase 2 Inhibitors, Enzyme Inhibitors
[+]

Fisetin has a strong anti-inflammatory activity in brain microglia, and could be a potential therapeutic agent for the treatment of neuroinflammatory diseases.Mar 01, 2008

Pubmed Data : Int Immunopharmacol. 2008 Mar;8(3):484-94. Epub 2008 Jan 16. PMID: 18279803
Article Published Date : Mar 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Fisetin, Flavonoids
Diseases : Brain: Microglial Activation, Brain Inflammation , Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Neuroprotective Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Fisetin induces programmed cell death in colon cancer cells by inhibiting inflammatory enzymes and signaling pathways. Feb 01, 2009

Pubmed Data : Carcinogenesis. 2009 Feb;30(2):300-7. Epub 2008 Nov 26. PMID: 19037088
Article Published Date : Feb 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Fisetin, Flavonoids
Diseases : Colon Cancer
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
Additional Keywords : Plant Extracts
[+]

Food contaminant acrylamide increases inflammation in breast cells.Jan 31, 2011

Pubmed Data : Toxicol Ind Health. 2011 Feb ;27(1):11-8. Epub 2010 Aug 16. PMID: 20713430
Article Published Date : Jan 31, 2011
Study Type : In Vitro Study
Additional Links
Diseases : Breast Cancer: Prevention
Pharmacological Actions : Cyclooxygenase 2 Inhibitors
Problem Substances : Acrylamide
Adverse Pharmacological Actions : Cycloogenase-2 enzyme upregulation, Inflammatory, iNOS upregulation
[+]

Gamma tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment.Nov 01, 2010

Pubmed Data : Cancer Res. 2010 Nov 1;70(21):8695-705. Epub 2010 Sep 23. PMID: 20864511
Article Published Date : Nov 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienol: Gamma
Diseases : Cancers: Drug Resistant, Inflammation, Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor, NF-kappaB Inhibitor
Additional Keywords : Drug: Gemcitabine, Drug Synergy
[+]

Gardenblue blueberry has potential use as a functional food for the treatment of inflammatory diseases.May 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Zhejiang Univ Sci B. 2016 Jun ;17(6):425-36. PMID: 27256676
Article Published Date : May 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Blueberry
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Gintonin potently suppresses the nitric oxide and also efficiently suppressed the levels of proinflammatory cytokines.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:624132. Epub 2015 Oct 12. PMID: 26579204
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Ginseng (Korean)
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, MicroRNA modulator, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Dose Response
[+]

Gleditsia sinensis has an inhibitory effect on cyclooxygenase-2 expression in human esophageal squamous cell carcinoma. Jan 01, 2009

Pubmed Data : Int J Mol Med. 2009 Jan;23(1):121-9. PMID: 19082515
Article Published Date : Jan 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Gleditsia sinensis
Diseases : Esophageal Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts
[+]

Green mussel lipid extracts have anti-cyclooxygenase activity superior to fish oil. Mar 01, 2007

Pubmed Data : Comp Biochem Physiol B Biochem Mol Biol. 2007 Mar;146(3):346-56. Epub 2006 Nov 17. PMID: 17197217
Article Published Date : Mar 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Fish Oil, Mussel: Green-lipped (Perna canaliculus)
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors
Additional Keywords : Drug: Indomethacin, Green Muscle Lipids Superior to Fish Oil Lipids
[+]

Guggul may have therapeutic value in the treatment of otitis media.Dec 01, 2010

Pubmed Data : Int J Pediatr Otorhinolaryngol. 2010 Dec;74(12):1384-7. Epub 2010 Oct 23. PMID: 20971513
Article Published Date : Dec 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Guggul
Diseases : Lipopolysaccharide-Induced Toxicity, Otitis media
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

HDMPPA may exert anti-inflammatory responses by suppressing LPS-induced expression of proinflammatory mediators and cytokines.May 31, 2015

Pubmed Data : J Med Food. 2015 Jun ;18(6):677-84. Epub 2015 Apr 28. PMID: 25919915
Article Published Date : May 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Kimchi
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Horseradish root extracts had an anti-inflammatory action. Dec 01, 2015

Pubmed Data : Food Funct. 2015 Dec 2 ;6(12):3778-88. PMID: 26411988
Article Published Date : Dec 01, 2015
Study Type : In Vitro Study
Additional Links
Substances : Horseradish
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Huperzine A protects against brain oxygen-glucose deprivation-induced injury. Feb 20, 2007

Pubmed Data : FEBS Lett. 2007 Feb 20;581(4):596-602. Epub 2007 Jan 18. PMID: 17257593
Article Published Date : Feb 20, 2007
Study Type : In Vitro Study
Additional Links
Substances : Huperzine
Diseases : Brain Hypoxia, Brain Inflammation , Hypoxia
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Hyaluronan inhibits prostaglandin E2 (inflammatory hormone) production in human macrophages.Jan 01, 2010

Pubmed Data : Tohoku J Exp Med. 2010;220(3):229-35. PMID: 20208419
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Hyaluronic Acid
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors, NF-kappaB Inhibitor, Prostaglandin PGF2 downregulation
[+]

Inhibition of Akt signalling and activation of GSK-3β partially contributes to the pro-apoptotic effect of embelin in prostate cancer cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(8):e0134760. Epub 2015 Aug 7. PMID: 26252009
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : False Black Pepper
Diseases : Cancer Metastasis, Prostate Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors
[+]

Inhibitory effects of black pepper (Piper nigrum) extracts and compounds on human tumor cell proliferation, cyclooxygenase enzymes, lipid peroxidation and nuclear transcription factor-kappa-B.Aug 01, 2010

Pubmed Data : Nat Prod Commun. 2010 Aug;5(8):1253-7. PMID: 20839630
Article Published Date : Aug 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Black Pepper
Diseases : Tumors
Pharmacological Actions : Anticarcinogenic Agents, Antioxidants, Antiproliferative , Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Kahweol behaves as an anti-inflammatory and anti-angiogenic compound with potential use in antitumoral therapies.Dec 31, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2011 ;6(8):e23407. Epub 2011 Aug 9. PMID: 21858104
Article Published Date : Dec 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Kahweol
Diseases : Cancers: All, Inflammation
Pharmacological Actions : Anti-Angiogenic, Anti-Inflammatory Agents, Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]

Kava contains compounds with Cyclooxygenase enzyme inhibitory and antioxidant properties.Jan 01, 2002

Pubmed Data : Phytomedicine. 2002 Jan;9(1):41-7. PMID: 11924763
Article Published Date : Jan 01, 2002
Study Type : In Vitro Study
Additional Links
Substances : Kava Kava
Diseases : Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts
[+]

Korean red ginseng extract can enhance the anticancer activity of imatinib mesylate and may have a substantial potential in the treatment of chronic myelogenous leukemia.Apr 07, 2015

Pubmed Data : Phytother Res. 2015 Apr 8. Epub 2015 Apr 8. PMID: 25857479
Article Published Date : Apr 07, 2015
Study Type : In Vitro Study
Additional Links
Substances : Ginseng (Korean)
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Chemosensitizer, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts
[+]

Korean red ginseng water extract inhibited the hypoxic induction of COX-2 expression and cell invasion through Sirt1 activation.May 31, 2015

Pubmed Data : Phytomedicine. 2015 Jun 1 ;22(6):597-604. Epub 2015 Mar 20. PMID: 26055124
Article Published Date : May 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Ginseng (Korean)
Diseases : Hypoxia
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, SIRT1 Activator
Additional Keywords : Plant Extracts
[+]

Liposome-encapsulated curcumin exhibits anti-cancer activity in pancreatic cancer.Sep 15, 2005

Pubmed Data : Cancer. 2005 Sep 15;104(6):1322-31. PMID: 16092118
Article Published Date : Sep 15, 2005
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Pancreatic Cancer
Pharmacological Actions : Anti-Angiogenic, Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Long-term administration of ω-3 PUFAs as a dietary supplement can be used as a strategy either to prevent CAC in patients.Aug 22, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2016 Aug 23. Epub 2016 Aug 23. PMID: 27566583
Article Published Date : Aug 22, 2016
Study Type : In Vitro Study
Additional Links
Substances : Polyunsaturated Fatty Acids (PUFAs)
Diseases : Colitis, Colorectal Cancer: Prevention
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Bcl-2 protein down-regulation, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Survivin Down-Regulation
[+]

Loquate leaves suppress lipopolysaccharide-induced adverse, pro-inflammatory changes in mouse macrophages.Jan 01, 2010

Pubmed Data : Am J Chin Med. 2010;38(5):985-94. PMID: 20821828
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Loquat Leaves
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Nitric Oxide Inhibitor
[+]

Low m