Cyclooxygenase 2 Inhibitors

Name	AC	CK
Curcumin	61	87
Flavonoids	13	27
Resveratrol	17	23
Omega-3 Fatty Acids	6	17
Sulforaphane	11	14
Apples	2	12
DHA (Docosahexaenoic Acid)	3	12
Spirulina	2	12
EPA (Eicosapentaenoic Acid)	2	11
Turmeric	2	11
Eicosapentaenoic acid (EPA)	1	10
Frankincense	1	10
Polyphenols	6	10
Strawberry	1	10
Vitamin C	1	10
Stilbenes	5	8
Cannabis	3	7
Melatonin	4	6
Astaxanthin	3	5
Berberine	3	5
Chrysin	3	5
Ginger	3	5
Noni	3	5
Pterostilbene	4	5
Wogonin	3	5
Anthocyanins	2	4
Black Tea	3	4
Bromelain	4	4
Dandelion	4	4
Flaxseed	2	4
Fucoidan	3	4
Ginkgo biloba	2	4
Lignans	2	4
Medium Chain Triglycerides	2	4
Nobiletin	3	4
Palm Oil	2	4
Pomegranate	3	4
Quercetin	3	4
Saturated fatty acids	2	4
Sweet Potato: Purple	2	4
Thymoquinone	2	4
18β-Glycyrrhetinic Acid	2	3
Antrodia camphorata	2	3
Apigenin	2	3
Blueberry	2	3
Chaga Mushroom (Inonotus obliquus)	2	3
Chinese Skullcap	2	3
Citrus Peel	2	3
Fermented Foods and Beverages	2	3
Ginseng (American)	2	3
Ginseng (Korean)	3	3
Mangiferin	2	3
Rose	2	3
Saffron	2	3
ALA (Alpha-Linolenic Acid)	1	2
Alpha Linolenic Acid	1	2
Apple Polyphenols	1	2
Arginine	1	2
Artemisia asiatica	1	2
Bee Propolis	1	2
Benzyl isothiocyanate	1	2
Boswellia	1	2
Brown Rice	1	2
Burdock	1	2
Caffeic acid phenethyl ester	1	2
Carrot	1	2
Catechin	2	2
Cocoa	1	2
Crocetin	1	2
Cyanidin 3-glucoside	1	2
Damnacanthal	1	2
EGCG (Epigallocatechin gallate)	2	2
Evening Primrose Oil	1	2
Fisetin	2	2
Fucoxanthin	1	2
Garcinia indica	1	2
Gardenia	1	2
Garlic	1	2
Gingerol	1	2
Grape Seed Extract	1	2
Graviola	1	2
Guggul	2	2
Hops	1	2
Kaempferia parviflora	1	2
L-Carnitine	1	2
Lactobacillus rhamnosus	1	2
Lion's Mane (Hericium Erinaceus)	1	2
Moringa oleifera	1	2
Mulberry	1	2
Myricetin	1	2
Noni leaf extract	1	2
Patchouli	1	2
Peony	1	2
Perilla	1	2
Pine Needle	1	2
Polyunsaturated Fatty Acids (PUFAs)	1	2
Potato	1	2
Probiotics	1	2
Raspberry	1	2
Red Wine	1	2
Rice Bran	1	2
Rosmarinic acid	1	2
Royal Jelly	1	2
Rutin	1	2
Sour Cherry	1	2
Tangeretin	1	2
Tongkat Ali	1	2
Walnut	1	2
Achillea fragrantissima	1	1
Alpha-Lipoic Acid	1	1
Artesunate	1	1
Asparagus	1	1
Avenanthramides	1	1
Avocado	1	1
Bamboo	1	1
Bee Venom	1	1
Beta-glucan	1	1
Betulinic acid	1	1
Black Pepper	1	1
Butterbur	1	1
Capsaicin	1	1
Chamomile	1	1
Cucurbitacin B	1	1
Cumin	1	1
Cyanidin	1	1
Echinacea	1	1
Ferulic acid	1	1
Feverfew	1	1
Fish Oil	1	1
Fruit: All	1	1
Ginsenosides	1	1
Gleditsia sinensis	1	1
Guava	1	1
Horseradish	1	1
Huperzine	1	1
Hyaluronic Acid	1	1
Hydroxytyrosol	1	1
Kava Kava	1	1
Kimchi	1	1
Long Pepper	1	1
Loquat Leaves	1	1
Lutein	1	1
Luteolin	1	1
Maitake Mushroom	1	1
Medicinal Mushrooms	1	1
Mushrooms: All	1	1
Mussel: Green-lipped (Perna canaliculus)	1	1
Oats	1	1
Oleuropein	1	1
Olive	1	1
Orange: Mandarin	1	1
Oranges	1	1
Phenethyl isothiocyanate	1	1
Piceatannol	1	1
Piperlongumine	1	1
Plantago	1	1
Prunella vulgaris.	1	1
Purple Carrots	1	1
Reishi Mushroom	1	1
Rice: Black	1	1
Rose Hips	1	1
Saw Palmetto	1	1
Sesame Seeds	1	1
Soy	1	1
Tabebuia	1	1
Theaflavins	1	1
Tocotrienol: Gamma	1	1
Toona sinensis	1	1
Truffles	1	1
Turmerones	1	1
Tyrosol	1	1
Unsaponifiables	1	1
Ursolic Acid	1	1
Vegetables: All	1	1
Wormwood	1	1
Wasabi	1	0

[+]

A daily dose of 3.6 g curcumin achieves pharmacologically efficacious levels in the colorectum with negligible distribution of curcumin outside the gut.Jan 01, 2005

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Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):120-5. PMID: 15668484

Article Published Date : Jan 01, 2005

Study Type : Human Study

Additional Links

Substances : Curcumin

Diseases : Colorectal Cancer

Pharmacological Actions : Chemopreventive, Cyclooxygenase 2 Inhibitors

Additional Keywords : Antineoplastic Agents

[+]

A formulation containing Frankincense and Turmeric extracts demonstrated a greater improvement in the treatment of OA than celecoxib.Oct 31, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Toxicol Appl Pharmacol. 2011 Feb 15 ;251(1):85-94. Epub 2010 Dec 15. PMID: 21167192

Article Published Date : Feb 15, 2011

Study Type : Animal Study

Additional Links

Substances : Flavonoids

Diseases : Liver Cancer: Prevention

Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors, Tumor Suppressor Protein p53 Upregulation

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : J Clin Biochem Nutr. 2015 Mar ;56(2):132-42. Epub 2014 Nov 28. PMID: 25759519

Article Published Date : Feb 28, 2015

Study Type : Animal Study

Additional Links

Substances : Artemisia asiatica

Diseases : Gastrointestinal Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Gastroprotective, Nrf2 activation

Additional Keywords : Dose Response

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Ascorbic acid contributes to the reduction of oxidative stress and inﬂammatory response in DSS-induced colitis.Dec 31, 2014

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Pubmed Data : Nutrients. 2016 Jul 21 ;8(7). Epub 2016 Jul 21. PMID: 27455313

Article Published Date : Jul 20, 2016

Study Type : Animal Study

Additional Links

Substances : Barley

Diseases : Alcohol Toxicity , Chemically-Induced Liver Damage, Lipopolysaccharide-Induced Toxicity, Oxidative Stress

Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, Hepatoprotective

Additional Keywords : Plant Extracts

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Carcinogenesis. 2010 Feb ;31(2):239-45. Epub 2009 Jul 22. PMID: 19625346

Article Published Date : Jan 31, 2010

Study Type : Animal Study

Additional Links

Substances : Indole-3-Carbinol, Myo-inositol

Diseases : Lung Cancer

Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors

Problem Substances : Vinyl Carbamate

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C. obtusa essential oil may constitute a novel source of anti-inflammatory treatments. Jun 30, 2013

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Pubmed Data : Mol Med Rep. 2013 Jul ;8(1):255-9. Epub 2013 May 8. PMID: 23652412

Article Published Date : Jun 30, 2013

Study Type : Animal Study

Additional Links

Substances : Japanese cypress

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Oils

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Cocoa may merit further clinical investigation as a chemopreventive agent that helps prevent colitis-associated cancer. Dec 31, 2014

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Pubmed Data : Cancer Res. 2009 Dec 1;69(23):8958-66. Epub 2009 Nov 10. PMID: 19903839

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Pubmed Data : Clin Cancer Res. 2005 Oct 15;11(20):7490-8. PMID: 16243823

Dietary saturated fatty acids down-regulate cyclooxygenase-2 and tumor necrosis factor alfa and reverse fibrosis in alcohol-induced liver disease in the rat.Dec 01, 1997

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Pubmed Data : Hepatology. 1997 Dec;26(6):1538-45. PMID: 9397995

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Pubmed Data : Int J Physiol Pathophysiol Pharmacol. 2014 ;6(1):23-36. Epub 2014 Mar 13. PMID: 24665356

Article Published Date : Dec 31, 2013

Study Type : Animal Study

Additional Links

Substances : Evening Primrose Oil

Diseases : Myocardial Infarction

Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Extracts of R. officinalis and rosmarinic acid through modulating neuro-inflammation might be potential candidates in treating neuropathic pain.Dec 21, 2016

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Pubmed Data : Biomed Pharmacother. 2016 Dec 22 ;86:441-449. Epub 2016 Dec 22. PMID: 28012923

Pubmed Data : Int Immunopharmacol. 2011 Feb ;11(2):157-63. Epub 2010 Nov 26. PMID: 21084063

Article Published Date : Jan 31, 2011

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Pubmed Data : Food Chem Toxicol. 2009 Jun;47(6):1190-7. Epub 2009 Feb 20. PMID: 19233241

Article Published Date : Jun 01, 2009

Study Type : Animal Study

Additional Links

Substances : Ginger

Diseases : Brain: Microglial Activation, Brain Inflammation , Inflammation, Lipopolysaccharide-Induced Toxicity, Neurodegenerative Diseases

Pharmacological Actions : Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Prostaglandin Antagonists

[+]

Gingerol could protect against experimental liver fibrosis in rats.Jan 25, 2016

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Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2016 Jan 26. Epub 2016 Jan 26. PMID: 26809353

Article Published Date : Jan 25, 2016

Study Type : Animal Study

Additional Links

Substances : Gingerol

Diseases : Chemically-Induced Liver Damage, Liver Fibrosis

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Ginkgo biloba extract anti-inflammatory properties and ameliorates colitis in mice. Sep 01, 2008

Pubmed Data : Biomed Pharmacother. 2016 Apr ;79:231-40. Epub 2016 Mar 11. PMID: 27044833

Mulberry fruit suppressed the development of intestinal inflammation and tumorgenesis both in vitro and in vivo.Dec 31, 2014

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Pubmed Data : Photodermatol Photoimmunol Photomed. 2014 Oct ;30(5):237-45. Epub 2014 Jan 9. PMID: 24313661

Pubmed Data : Photochem Photobiol. 2010 Nov-Dec;86(6):1318-26. Epub 2010 Oct 14. PMID: 20946358

Article Published Date : Nov 01, 2010

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Pubmed Data : Exp Biol Med (Maywood). 2011 Jan;236(1):99-106. PMID: 21239739

Article Published Date : Jan 01, 2011

Study Type : Animal Study

Additional Links

Substances : Perilla , Rosmarinic acid

Diseases : Allergic Rhinitis, Allergic Rhinoconjunctivitis

Pharmacological Actions : Anti-Allergic Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor

Additional Keywords : Plant Extracts

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Phloretin inhibits phorbol ester-induced tumor promotion and expression of cyclooxygenase-2 in mouse skin.Feb 29, 2012

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Pubmed Data : J Med Food. 2012 Mar ;15(3):253-7. Epub 2011 Dec 19. PMID: 22181070

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Pubmed Data : Int J Mol Sci. 2017 Jan 12 ;18(1). Epub 2017 Jan 12. PMID: 28085116

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Pubmed Data : Pharm Res. 2010 Jun;27(6):1080-91. Epub 2010 Apr 20. PMID: 20405173

The ethanolic extract of Justicia gendarussa showed significant anti-arthritic activity that was statistically similar to that of aspirin.Dec 31, 2008

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Pubmed Data : Clinics (Sao Paulo). 2009 ;64(4):357-62. PMID: 19488595

Article Published Date : Dec 31, 2008

Study Type : Animal Study

Additional Links

Substances : Justicia gendarussa

Diseases : Arthritis

Pharmacological Actions : 5-Lipoxygenase Inhibitor, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors

Additional Keywords : Natural Substances Versus Drugs, Plant Extracts

[+]

The flower extract of Rosa rugosa may be a beneficial anti-inflammatory agent.Feb 29, 2016

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Pubmed Data : Br J Nutr. 2015 Sep ;114(6):853-865. PMID: 26334388

Article Published Date : Aug 31, 2015

Study Type : Animal Study

Additional Links

Substances : Mangiferin, Quercetin, Resveratrol

Diseases : Pulmonary Fibrosis, Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors

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These findings strongly suggest that the anti-inflammatory actions of Thymoquinone are caused by suppression of IRAK-linked AP-1/NF-κB pathways.Feb 19, 2017

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Pubmed Data : J Cell Biochem. 2011 Jan ;112(1):107-17. PMID: 20872780

Article Published Date : Dec 31, 2010

Study Type : Animal Study

Additional Links

Substances : Thymoquinone

Diseases : Inflammation, Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Anti-Inflammatory Agents, Antiproliferative, Inflammation, rheumatoid arthritis, thymoquinone

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Thymoquinone augmented the chemopreventive effect of vitamin D during the initiation phase of colon cancer.Dec 31, 2016

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Pubmed Data : Molecules. 2017 May 18 ;22(5). Epub 2017 May 18. PMID: 28524081

Article Published Date : May 17, 2017

Study Type : Animal Study

Additional Links

Substances : Loquat

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

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Wogonin and 5-fluorouracil combination treatment caused a significant growth inhibition of human tumor xenografts in vivo.Jul 31, 2013

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Pubmed Data : Biochem Cell Biol. 2013 Aug ;91(4):221-9. Epub 2013 Feb 14. PMID: 23859016

ω-3 polyunsaturated fatty acids had inhibitory effects on endometrial cancer development.Dec 31, 2014

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Pubmed Data : Sci Rep. 2015;5:14958. Epub 2015 Oct 15. PMID: 26468779

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Polyunsaturated Fatty Acids (PUFAs)

Diseases : Endometrial Cancer

Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation

Additional Keywords : Risk Reduction

[+]

"Anti-inflammatory effects of fucoidan through inhibition of NF-κB, MAPK and Akt activation in lipopolysaccharide-induced BV2 microglia cells."Jul 31, 2011

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Pubmed Data : Food Chem Toxicol. 2011 Aug ;49(8):1745-52. Epub 2011 May 4. PMID: 21570441

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Pubmed Data : J Surg Res. 2009 Dec;157(2):261-7. Epub 2009 Jun 6. PMID: 19815237

Article Published Date : Dec 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Ginseng (American)

Diseases : Breast Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor

Additional Keywords : Plant Extracts

[+]

An extract of Lotus may be a powerful agent against colon cancer cells.Feb 28, 2017

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Pubmed Data : Di Yi Jun Yi Da Xue Xue Bao. 2005 Jan;25(1):48-52. PMID: 15683997

Article Published Date : Jan 01, 2005

Study Type : In Vitro Study

Additional Links

Substances : Catechin , Curcumin

Diseases : Colon Cancer

Pharmacological Actions : Cyclooxygenase 2 Inhibitors

Additional Keywords : Natural Substance Synergy

[+]

Curcumin and resveratrol compare favorably with NSAID agents in inhibiting inflammatory processes associated with tumor cell proliferation.Dec 09, 2004

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Pubmed Data : Oncogene. 2004 Dec 9;23(57):9247-58. PMID: 15489888

[+]

Curcumin may be effective for the prevention of severe lower respiratory tract disease in infants and young children.Dec 31, 2012

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Pubmed Data : Rheumatology (Oxford). 2006 Feb;45(2):171-7. Epub 2005 Oct 25. PMID: 16249246

Article Published Date : Feb 01, 2006

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Osteoarthritis: Knee, Oxidative Stress

Pharmacological Actions : Antioxidants, Antiproliferative , Apoptotic, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors

Additional Keywords : Drug: Celecoxib, Drug Synergy

[+]

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Pubmed Data : Oncotarget. 2017 Jan 25. Epub 2017 Jan 25. PMID: 28135203

Article Published Date : Jan 24, 2017

Study Type : In Vitro Study

Additional Links

Substances : Ellagic Acid

Diseases : Pancreatic Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor

Additional Keywords : Dose Response

[+]

Epinephrine stimulates esophageal squamous-cell carcinoma cell proliferation.Sep 01, 2008

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Pubmed Data : J Cell Biochem. 2008 Sep 1 ;105(1):53-60. PMID: 18452159

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Pubmed Data : Toxicol Ind Health. 2011 Feb ;27(1):11-8. Epub 2010 Aug 16. PMID: 20713430

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Pubmed Data : J Zhejiang Univ Sci B. 2016 Jun ;17(6):425-36. PMID: 27256676

Article Published Date : May 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Blueberry

Diseases : Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Gintonin potently suppresses the nitric oxide and also efficiently suppressed the levels of proinflammatory cytokines.Dec 31, 2014

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Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:624132. Epub 2015 Oct 12. PMID: 26579204

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View the Evidence: 384 Abstracts with Cyclooxygenase 2 Inhibitors Research

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A daily dose of 3.6 g curcumin achieves pharmacologically efficacious levels in the colorectum with negligible distribution of curcumin outside the gut.Jan 01, 2005

A formulation containing Frankincense and Turmeric extracts demonstrated a greater improvement in the treatment of OA than celecoxib.Oct 31, 2013

Consumption of dried apple peel powder was associated with improved joint function and improved serum antioxidant protection status.Oct 31, 2014

Dietary strawberries significantly decreased the histologic grade of patients' precancerous esophageal lesions.Dec 31, 2011

Electroacupuncture may prevent ischemia-reperfusion-induced endothelial dysfunction via a COX-2 dependent mechanism.Dec 31, 2016

Electroacupuncture treatment alleviates central post-stroke pain.Dec 31, 2015

EPA supplementation significantly reduces Cox-2 enzyme expression in Barrett's esophagus.Apr 01, 2008

Omega-3 fatty acids cause a reduction in the mRNA levels for various proteins known to be important in the pathology of osteoarthritis. Jul 01, 2009

Phloretin inhibits the growth of P. acnes, P. granulosum, and S. epidermidis.Jan 31, 2016

Pycnogenol may be of value in treatment of MSU crystal-induced arthritis through its anti-inflammatory and anti-nitrosative activities.Feb 14, 2012

Spirulina has favorable effects on lipid profiles, immune variables and antioxidant capacity in healthy individuals.Jan 01, 2008

These new data support a potential role of oleuropein in the treatment of ulcerative colitis.Apr 14, 2017

Vitamin C attenuates aspirin-induced gastric damage. May 01, 2009

Cannabidiolic acid an active component in the cannabis plant offers potential therapeutic modality in the abrogation of cancer cell migration.Nov 14, 2012

Ginsenoside Rg1 can inhibit inflammatory responses in human chondrocytes in vitro and reduce articular cartilage damage in vivo.Mar 09, 2017

Melatonin as a novel selective ATF-6 inhibitor can sensitize human hepatoma cells to ER stress inducing apoptosis.Feb 13, 2017

Melatonin is a potential candidate compound for the treatment of proinflammatory disorders.Aug 31, 2012

Oleuropein might provide a basis for developing a new dietary strategy for the prevention and management of rheumatoid arthritis.Apr 19, 2017

Phloretin inhibits interleukin-1β-induced COX-2 and ICAM-1 in human lung epithelial cells.May 31, 2015

Resveratrol functions as a suppressor of particulate matter induced inflammatory signalling pathways.May 07, 2017

Berberin inhibited colorectal cancer invasion and metastasis via down regulation of COX-2/PGE2- JAK2/STAT3 signaling pathway.Dec 31, 2014

"Chrysin abrogates early hepatocarcinogenesis and induces apoptosis in N-nitrosodiethylamine-induced preneoplastic nodules in rats."Feb 15, 2011

18β-Glycyrrhetinic acid significantly attenuated H. pylori-infected gastritis in gerbils.Dec 31, 2015

5-FU and thymoquinone combination therapy resulted in a more significant reduction on AOM-induced colorectal tumors.Dec 31, 2015

A Burdock extract was able to reduce intestinal inflammation in an acute TNBS-induced experimental model of colitis in rats.Mar 06, 2013

A combination of ginger and peony root may prevent memory impairment in AD by inhibiting Aβ accumulation and inflammation in the brain.Nov 29, 2015

Allylmethylsulfide (AMS), a volatile organosulfur derivative from garlic has radioprotective properties.Jun 01, 2009

Alpha linolenic fatty acid supplementation had a beneficial effect on tumor cell proliferation and cachexia parameters.May 25, 2015

American ginseng prevents and treats Ulcerative Colitis.Sep 18, 2008

Anthocyanin-rich fractions from red raspberries attenuate inflammation both in vitro and in vivo.Dec 31, 2013

Anti-inflammatory mechanisms could be involved in pomegranate-mediated prevention of breast cancer.Apr 27, 2017

Antrodia camphorata extract, when combined with anti-tumor agents, showed adjuvant antiproliferative effects on multi-drug resistant hepatoma. Aug 13, 2008

Apigenin and myricetin exhibited a protective and promising preventive strategy against cisplatin-induced nephrotoxicity.Nov 30, 2017

Apigenin, a dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation in mice. Jan 01, 2009

Apple polyphenols extract (APE) improves colon damage in a rat model of colitis.Feb 28, 2012

Apples rich polyphenols reduce colonic inflammation in rats. Dec 01, 2009

Arginine reverses ethanol-induced inflammatory and fibrotic changes in liver despite continued ethanol administration.Dec 01, 2001

Artemisia extracts were mucoprotective by attenuating stress related mucosal damages.Feb 28, 2015

Ascorbic acid contributes to the reduction of oxidative stress and inﬂammatory response in DSS-induced colitis.Dec 31, 2014

Astaxanthin exhibits anti-inflammatory and anti-cancer activity in a rat model of colon cnacer.Apr 01, 2011

Astaxanthin had an anti-depressant effect on diabetic mice.Dec 21, 2016

Barley sprouts have a protective effect against alcohol-induced liver injury.Jul 20, 2016

Benzyl isothiocyanate and sulforaphane protect against initiation of pancreatic carcinogenesis in hamsters.Sep 28, 2006

Berberine has a preventive effect on experimental colon cancer. Oct 01, 2010

Beta-caryophyllene constitutes an alluring therapeutic molecule towards the treatment of multiple sclerosis.Mar 31, 2017

Boswellia serrate extract has great potential to suppress colon tumorigenesis.Feb 27, 2017

Boswellic acid suppresses growth and metastatis of human pancreatic tumors (nude mouse model). Jan 01, 2011

Both indole-3-carbinol and myo-inositol inhibit the development of vinyl carbamate induced pulmonary adenocarcinoma in mice.Jan 31, 2010

C. obtusa essential oil may constitute a novel source of anti-inflammatory treatments. Jun 30, 2013

Caffeic acid phenethyl ester, a compound found within propolis causes regression of experimental endometriosis.Apr 01, 2007

Cannabidiol could be used to prevent experimental colitis in mice.Oct 31, 2009

Carrot seeds contain phytochemicals capable of inhibiting inflammatory enzymes.Jun 01, 2007

Chamaecyparis obtusa essential oil has anti-inflammatory and anti-nociceptive effects on arthritis in rats.Dec 31, 2014

Chinese skullcap (Scutellaria baicalensis) significantly improves functional recovery from spinal cord injury in rats by inhibiting inflammation and oxidative stress after injury.Aug 01, 2009

Cocoa may merit further clinical investigation as a chemopreventive agent that helps prevent colitis-associated cancer. Dec 31, 2014

Cocoa polyphenols may inhibit tumor promotion through antioxidant and antiinflammatory mechanisms.May 01, 2006

Crocetin supplementation in the MCA mice also showed protection against cervical cancer. Dec 31, 2014

Crocin, a carotenoid fround within Gardenia jasminoides and Crocus sativus (Safron) has significant anti-inflammatory activity. Sep 23, 2009

Curcumin ameliorates experimentally induced ulcerative colitis. Mar 01, 2007

Curcumin attenuated glucose intolerance and insulin resistance through its antioxidant and anti-inflammatory effects.Dec 19, 2015

Curcumin can enhance postsynaptic electrical reactivity and cell viability in intact neural circuits with antidepressant-like effects.Dec 31, 2016

Curcumin has therapeutic effects in chemically-induced colitis. Jun 28, 2006

Curcumin inhibits NF-kappaB activation and reduces the severity of experimental fatty liver in mice.Dec 01, 2003

Curcumin inhibits prostate cancer tumors. Dec 01, 2009

Curcumin inhibits trinitrobenzene sulphonic acid-induced colitis in rats.Aug 01, 2006

Curcumin may have therapeutic value in colon cancer prevention.Oct 28, 1999

Curcumin might be useful in the chemoprevention of colorectal cancer in individuals consuming an high-protein diet.Jul 31, 2015

Curcumin potentiated significant increase in Nrf2 activation. It restored activity of phase-II antioxidant enzymes like GST, GR, NQO1, and tumour suppressor p53 level. Dec 31, 2014

Curcumin potentiates the antitumor effects of Bacillus Calmette-Guerin against bladder cancer.Dec 01, 2009

Curcumin prevents colon carcinogenesis. Apr 01, 1999

Curcumin protects against necrotizing enterocolitis in neonatal rats.Feb 01, 2010

Curcumin reduces oxidative and nitrative DNA damage associated with fluke infection.Oct 01, 2009

Cyclooxygenase 2 Inhibitors

View the Evidence:
384 Abstracts with Cyclooxygenase 2 Inhibitors Research