Enzyme Inhibitors

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View the Evidence: Pharmacological Actions

A combination of quercetin, ascorbyl palmitate and vitamin D appears to safely offer relief of symptomatic diabetic neuropathy.

Pubmed Data : J Diabetes Complications. 2005 Sep-Oct;19(5):247-53. PMID: 16112498
Article Published Date : Sep 01, 2005
Study Type : Human Study
Additional Links
Substances : Ascorbyl Palmitate : CK(10) : AC(1), Quercetin : CK(318) : AC(136), Vitamin C : CK(1274) : AC(238), Vitamin D : CK(1682) : AC(238)
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Diabetic Neuropathies : CK(203) : AC(32), Peripheral Neuropathies : CK(394) : AC(31)
Pharmacological Actions : Enzyme Inhibitors : CK(372) : AC(208)

Antioxidants decreases the intensification of low density lipoprotein in vivo peroxidation during therapy with statins.

Pubmed Data : Mol Cell Biochem. 2003 Jul;249(1-2):129-40. PMID: 12956408
Article Published Date : Jul 01, 2003
Study Type : Human Study
Additional Links
Substances : Coenzyme Q10 : CK(667) : AC(104), Vitamin E : CK(1285) : AC(221)
Diseases : Atherosclerosis : CK(523) : AC(77), Cholesterol: Oxidation : CK(457) : AC(98), Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Enzyme Inhibitors : CK(372) : AC(208)

Curcumin suppresses of phosphorylase kinase activity which is correlated to a resolution of psoriasis.

Pubmed Data : Br J Dermatol. 2000 Nov;143(5):937-49. PMID: 11069500
Article Published Date : Nov 01, 2000
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Psoriasis : CK(270) : AC(42)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Dermatologic Agents : CK(124) : AC(13), Enzyme Inhibitors : CK(372) : AC(208), Phosphorylase Kinase Inhibitors : CK(10) : AC(1)

Curcuminoids may be used to ameliorate oxidative damage in patients with beta-thalassemia/Hb E disease.

Pubmed Data : Clin Biochem. 2010 Mar;43(4-5):424-9. Epub 2009 Nov 10. PMID: 19900435
Article Published Date : Mar 01, 2010
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Hemoglobinopathies : CK(20) : AC(2), Oxidative Stress : CK(1945) : AC(710), Thalassemia : CK(118) : AC(13)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Enzyme Inhibitors : CK(372) : AC(208)

Dandelion has pancreatic lipase activity which may have a therapeutic role in obesity.

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Res Pract. 2008;2(4):200-3. Epub 2008 Dec 31. PMID: 20016719
Article Published Date : Jan 01, 2008
Study Type : Human Study
Additional Links
Substances : Dandelion : CK(91) : AC(30)
Diseases : Obesity : CK(1849) : AC(275)
Pharmacological Actions : Enzyme Inhibitors : CK(372) : AC(208), Enzyme Inhibitors: Pancreatic Lipase : CK(12) : AC(2)

Genistein has therapeutic value in reducing PSA levels in men with prostate cancer.

Pubmed Data : Urology. 2004 Feb;63(2):259-63. PMID: 14972467
Article Published Date : Feb 01, 2004
Study Type : Human Study
Additional Links
Substances : Genistein : CK(450) : AC(174)
Diseases : Prostate: PSA Doubling : CK(133) : AC(16), Prostate Cancer : CK(998) : AC(288)
Pharmacological Actions : Enzyme Inhibitors : CK(372) : AC(208)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Licorice is effective in lowering potassium in hemodialysis patients with hyperkalemia.

Pubmed Data : Kidney Int. 2009 Oct;76(8):877-84. Epub 2009 Jul 29. PMID: 19641483
Article Published Date : Oct 01, 2009
Study Type : Human Study
Additional Links
Substances : Potassium : CK(99) : AC(15)
Diseases : Hyperkalemia : CK(14) : AC(3)
Pharmacological Actions : Enzyme Inhibitors : CK(372) : AC(208)

Statin therapy can be associated with high blood lactate/ pyruvate ratio suggestive of mitochondrial dysfunction.

Pubmed Data : Br J Clin Pharmacol. 1996 Sep ;42(3):333-7. PMID: 8877024
Article Published Date : Sep 01, 1996
Study Type : Human Study
Additional Links
Diseases : Blood Lactate/ Pyruvate Ratio: Elevated : CK(10) : AC(1), Coenzyme Q10 Deficiency : CK(83) : AC(13), Mitochondrial Dysfunction : CK(149) : AC(51), Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions : Enzyme Inhibitors : CK(372) : AC(208)
Problem Substances : Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Myotoxicity : CK(317) : AC(79)

Sulforaphane has a novel chemopreventive mechanism in human colon cancer cells and prostate epithelial cells, namely the inhibition of histone deacetylase (HDAC). I

Pubmed Data : Exp Biol Med (Maywood). 2007 Feb;232(2):227-34. PMID: 17259330
Article Published Date : Feb 01, 2007
Study Type : Human Study
Additional Links
Substances : Sulforaphane : CK(520) : AC(171)
Diseases : Colon Cancer : CK(895) : AC(233), Prostate Cancer : CK(998) : AC(288), Prostate Cancer: Prevention : CK(155) : AC(16)
Pharmacological Actions : Chemopreventive : CK(1528) : AC(382), Enzyme Inhibitors : CK(372) : AC(208), Histone deacetylase inhibitor : CK(26) : AC(16)

The administration of low-dose curcumin showed a trend of reduction in total cholesterol level and LDL cholesterol level in acute coronary syndrome patients.

Pubmed Data : Acta Med Indones. 2008 Oct;40(4):201-10. PMID: 19151449
Article Published Date : Oct 01, 2008
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Cholesterol: LDL/HDL ratio : CK(432) : AC(58), Coronary Artery Disease : CK(1305) : AC(136), High Cholesterol : CK(1718) : AC(198)
Pharmacological Actions : Enzyme Inhibitors : CK(372) : AC(208), Hypolipidemic : CK(370) : AC(80)

A potential link between HMG-CoA reductase inhibitor (statin) use and interstitial lung disease has been reported.

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med J Aust. 2007 Aug 20 ;187(4):253. PMID: 17708735
Article Published Date : Aug 20, 2007
Study Type : Human: Case Report
Additional Links
Diseases : Interstitial Lung Diseases : CK(70) : AC(12), Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions : Enzyme Inhibitors : CK(372) : AC(208)
Additional Keywords : Drug: Amiodarone : CK(3) : AC(1)
Problem Substances : Statin Drugs : CK(3969) : AC(465)

Statin-associated rhabdomyolysis triggered by grapefruit consumption has been reported.

Pubmed Data : Neurology. 2004 Feb 24 ;62(4):670. PMID: 14981197
Article Published Date : Feb 24, 2004
Study Type : Human: Case Report
Additional Links
Substances : Grapefruit : CK(109) : AC(30)
Diseases : Rhabdomyolysis : CK(165) : AC(38), Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142), Enzyme Inhibitors : CK(372) : AC(208)
Problem Substances : Simvastatin : CK(713) : AC(143)

Statin-induced impotence has been reported.

Pubmed Data : Ann Pharmacother. 1996 Feb ;30(2):192. PMID: 8835058
Article Published Date : Feb 01, 1996
Study Type : Human: Case Report
Additional Links
Diseases : Erectile Dysfunction : CK(510) : AC(41), Impotence : CK(13) : AC(2), Low Libido : CK(73) : AC(21)
Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142), Enzyme Inhibitors : CK(372) : AC(208)
Problem Substances : Statin Drugs : CK(3969) : AC(465)

Resveratrol may have potential therapeutic applications for prevention of diabetes-induced visual dysfunction.

Pubmed Data : Diabetes. 2010 Jul;59(7):1825-35. Epub 2010 Apr 27. PMID: 20424226
Article Published Date : Jul 01, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol : CK(977) : AC(590)
Diseases : Diabetes: Cataract : CK(23) : AC(13), Diabetes: Visual Dysfunction : CK(2) : AC(1)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Apoptotic : CK(1489) : AC(1114), Enzyme Inhibitors : CK(372) : AC(208)
Additional Keywords : Stilbenes : CK(402) : AC(242)

"Resveratrol prevents the wasting disorders of mechanical unloading by acting as a physical exercise mimetic in the rat."

Pubmed Data : FASEB J. 2011 Oct ;25(10):3646-60. Epub 2011 Jun 29. PMID: 21715682
Article Published Date : Oct 01, 2011
Study Type : Animal Study
Additional Links
Substances : Resveratrol : CK(977) : AC(590)
Diseases : Inflammation : CK(1077) : AC(363), Insulin Resistance : CK(1034) : AC(221), Space Flight Associated Adverse Changes : CK(2) : AC(1)
Pharmacological Actions : Enzyme Inhibitors : CK(372) : AC(208)

Age may play a significant role in the efficacy of chemoprevention of colon cancer by curcumin.

Pubmed Data : Nutr Cancer. 2004;48(1):37-43. PMID: 15203376
Article Published Date : Jan 01, 2004
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Colorectal Cancer : CK(877) : AC(321)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Enzyme Inhibitors : CK(372) : AC(208)

Apigenin demonstrates growth inhibitory activity in cultured breast cells and xenografts, without toxicity.

Pubmed Data : J Clin Sleep Med. 2009 Aug 15;5(4):377-83. PMID: 18300387
Article Published Date : Aug 15, 2009
Study Type : Animal Study
Additional Links
Substances : Apigenin : CK(76) : AC(51)
Diseases : Breast Cancer : CK(2354) : AC(621)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Enzyme Inhibitors : CK(372) : AC(208)

Bay leaf contains compounds which inhibit LPS-activated nitric oxide production and which induce heat shock protein.

Pubmed Data : Life Sci. 2000 Apr 21;66(22):2151-7. PMID: 10834299
Article Published Date : Apr 21, 2000
Study Type : Animal Study
Additional Links
Substances : Bay leaf : CK(55) : AC(27)
Diseases : Lipopolysaccharide-Induced Toxicity : CK(227) : AC(128)
Pharmacological Actions : Enzyme Inhibitors : CK(372) : AC(208), Heat Shock Protein Inducer : CK(51) : AC(17), Nitric Oxide Inhibitor : CK(108) : AC(57)

Both curcumin and resveratrol show promise as anti-cachexia agents, whereas resveratrol performed better in this study.

Pubmed Data : Br J Cancer. 2004 Nov 1;91(9):1742-50. PMID: 15477867
Article Published Date : Nov 01, 2004
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482), Resveratrol : CK(977) : AC(590)
Diseases : Cachexia : CK(40) : AC(8), Muscle Atrophy : CK(56) : AC(22)
Pharmacological Actions : Enzyme Inhibitors : CK(372) : AC(208), NF-kappaB Inhibitor : CK(595) : AC(401), Proteasome Inhibitors : CK(41) : AC(27)
Additional Keywords : Stilbenes : CK(402) : AC(242)

Cannabidiol has a neuroprotective effect in endotoxin-induced uveitis.

Pubmed Data : Mol Vis. 2008;14:2190-203. Epub 2008 Dec 3. PMID: 19052649
Article Published Date : Jan 01, 2008
Study Type : Animal Study
Additional Links
Substances : Cannabidiol : CK(391) : AC(92), Cannabis : CK(738) : AC(132)
Diseases : Brain: Microglial Activation : CK(67) : AC(38), Endotoxemia : CK(187) : AC(40), Lipopolysaccharide-Induced Toxicity : CK(227) : AC(128), Oxidative Stress : CK(1945) : AC(710), Uveitis : CK(63) : AC(10)
Pharmacological Actions : Enzyme Inhibitors : CK(372) : AC(208), Neuroprotective Agents : CK(962) : AC(480), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Chronic treatment of diabetic rats with genistein could prevent the abnormal functional changes in vascular reactivity in diabetic rats.

Pubmed Data : Vascul Pharmacol. 2008 Jul;49(1):1-5. Epub 2008 Mar 27. PMID: 18468493
Article Published Date : Jul 01, 2008
Study Type : Animal Study
Additional Links
Substances : Genistein : CK(450) : AC(174)
Diseases : Diabetes: Cardiovascular Illness : CK(666) : AC(104)
Pharmacological Actions : Cardioprotective : CK(702) : AC(196), Enzyme Inhibitors : CK(372) : AC(208)

Costunolide, a component of Bay leaf, inhibits blood-ethanol elevation in rats.

Pubmed Data : Alcohol Alcohol. 2002 Mar-Apr;37(2):121-7. PMID: 11912066
Article Published Date : Mar 01, 2002
Study Type : Animal Study
Additional Links
Substances : Bay leaf : CK(55) : AC(27)
Diseases : Alcohol Toxicity : CK(212) : AC(85)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57), Enzyme Inhibitors : CK(372) : AC(208)

Curcumin ameliorates acute thioacetamide-induced hepatotoxicity.

Pubmed Data : J Gastroenterol Hepatol. 2006 Feb;21(2):358-66. PMID: 16509859
Article Published Date : Feb 01, 2006
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Enzyme Inhibitors : CK(372) : AC(208), Hepatoprotective : CK(557) : AC(272), NF-kappaB Inhibitor : CK(595) : AC(401)

Curcumin ameliorates sodium arsenite induced biochemical perturbations in rats.

Pubmed Data : Food Chem Toxicol. 2008 Nov;46(11):3506-11. Epub 2008 Sep 2. PMID: 18809455
Article Published Date : Nov 01, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Arsenic Poisoning : CK(85) : AC(27)
Pharmacological Actions : Enzyme Inhibitors : CK(372) : AC(208)

Curcumin and NAC prevent fatty acid changes produced by ethanol and also reduce the inflammatory response of ethanol by reducing the level of prostaglandins.

Pubmed Data : Pain. 2005 Mar;114(1-2):266-77. Epub 2005 Jan 26. PMID: 11504446
Article Published Date : Mar 01, 2005
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482), NAC (N-acetyl-L-cysteine) : CK(264) : AC(62)
Diseases : Alcohol Toxicity : CK(212) : AC(85)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Enzyme Inhibitors : CK(372) : AC(208), Hepatoprotective : CK(557) : AC(272), Prostaglandin PGE2 downregulation : CK(28) : AC(15)

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