Epidermal growth factor receptor (EGFR) inhibitor

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View the Evidence: Pharmacological Actions

Curcumin inhibits amyloid-petpide induced changes associated with the progression of Alzheimer's disease.

Pubmed Data : J Neurochem. 2004 Dec;91(5):1199-210. PMID: 15569263
Article Published Date : Dec 01, 2004
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Alzheimer's Disease : CK(826) : AC(160)
Pharmacological Actions : Enzyme Inhibitors : CK(372) : AC(208), Epidermal growth factor receptor (EGFR) inhibitor : CK(27) : AC(22), Neuroprotective Agents : CK(962) : AC(480)

Flaxseed oil reduces the growth of human breast tumors (MCF-7) at high levels of circulating estrogen.

Pubmed Data : Mol Nutr Food Res. 2010 Oct;54(10):1414-21. PMID: 20425756
Article Published Date : Oct 01, 2010
Study Type : Animal Study
Additional Links
Substances : Flaxseed : CK(275) : AC(57), Omega-3 Fatty Acids : CK(3333) : AC(319)
Diseases : Breast Cancer : CK(2354) : AC(621)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Epidermal growth factor receptor (EGFR) inhibitor : CK(27) : AC(22)

Fucoidan exhibits a gastro-protective effect against aspirin-induced ulceration in rats.

Pubmed Data : Int Immunopharmacol. 2011 Feb ;11(2):157-63. Epub 2010 Nov 26. PMID: 21084063
Article Published Date : Jan 31, 2011
Study Type : Animal Study
Additional Links
Substances : Fucoidan : CK(152) : AC(72)
Diseases : Aspirin-Induced Toxicity : CK(83) : AC(24), Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57), Cyclooxygenase 1 Inhibitor : CK(22) : AC(18), Cyclooxygenase 2 Inhibitors : CK(269) : AC(169), Epidermal growth factor receptor (EGFR) inhibitor : CK(27) : AC(22)
Problem Substances : Aspirin : CK(471) : AC(64)
Adverse Pharmacological Actions : Ulcerogenic : CK(66) : AC(9)

Graviola selectively suppresses human breast cancer cells.

Pubmed Data : Nutr Cancer. 2011 ;63(5):795-801. Epub 2011 Jun 22. PMID: 21767082
Article Published Date : Jan 01, 2011
Study Type : Animal Study
Additional Links
Substances : Graviola : CK(7) : AC(6)
Diseases : Breast Cancer : CK(2354) : AC(621)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Epidermal growth factor receptor (EGFR) inhibitor : CK(27) : AC(22), Oncogene Suppressor : CK(14) : AC(10)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Omega-3 polyunsaturated fatty acids has a preventive effect against atrial fibrillation in a canine model of pericarditis.

Pubmed Data : Heart Rhythm. 2010 Apr;7(4):520-8. Epub 2009 Dec 28. PMID: 20156610
Article Published Date : Apr 01, 2010
Study Type : Animal Study
Additional Links
Substances : Omega-3 Fatty Acids : CK(3333) : AC(319)
Diseases : Atrial Fibrillation : CK(441) : AC(45), Pericarditis : CK(35) : AC(5)
Pharmacological Actions : Cardiovascular Agents : CK(50) : AC(10), Epidermal growth factor receptor (EGFR) inhibitor : CK(27) : AC(22), JAM3 gene down-regulation : CK(2) : AC(1), Myosin heavy chain alpha (MHCalpha) reducer : CK(2) : AC(1), Protein Kinase Inhibitors : CK(15) : AC(11)

Saccharomyces boulardii may have a preventive role in intestinal and colon cancer.

Pubmed Data : Gastroenterology. 2009 Sep;137(3):914-23. Epub 2009 May 29. PMID: 19482027
Article Published Date : Sep 01, 2009
Study Type : Animal Study
Additional Links
Substances : Saccharomyces Boulardii : CK(137) : AC(23)
Diseases : Colon Cancer : CK(895) : AC(233), Intestinal Cancer : CK(37) : AC(9)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Epidermal growth factor receptor (EGFR) inhibitor : CK(27) : AC(22)

Andrographis contains a compound which may induce cancer cell death through epidermal factor receptor and transferrin receptor modulation.

Pubmed Data : Br J Pharmacol. 2010 Apr;159(7):1497-510. Epub 2010 Feb 19. PMID: 20233216
Article Published Date : Apr 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Andrographis : CK(81) : AC(35)
Diseases : Skin Cancer: Squamous Cell : CK(52) : AC(16)
Pharmacological Actions : Epidermal growth factor receptor (EGFR) inhibitor : CK(27) : AC(22)

Constituents of avocado fruits inhibit human oral cancer cell proliferation.

Pubmed Data : Biochem Biophys Res Commun. 2011 Jun 10 ;409(3):465-9. Epub 2011 May 8. PMID: 21596018
Article Published Date : Jun 10, 2011
Study Type : In Vitro Study
Additional Links
Substances : Avocado : CK(47) : AC(17)
Diseases : Oral Cancer : CK(66) : AC(43)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Epidermal growth factor receptor (EGFR) inhibitor : CK(27) : AC(22)

Curcumin and betulinic acid downregulate epidermal growth factor receptor in bladder cancer cells.

Pubmed Data : Mol Cancer Res. 2010 May;8(5):739-50. Epub 2010 Apr 20. PMID: 20407012
Article Published Date : May 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid : CK(6) : AC(6), Curcumin : CK(2910) : AC(1482)
Diseases : Bladder Cancer : CK(186) : AC(60)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Epidermal growth factor receptor (EGFR) inhibitor : CK(27) : AC(22)

Curcumin and genistein may positively modulate EGF and therefore playing a therapeutic role in periodontal disease.

Pubmed Data : J Periodontal Res. 2004 Dec;39(6):380-7. PMID: 15491342
Article Published Date : Dec 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482), Genistein : CK(450) : AC(174)
Diseases : Periodontal Diseases : CK(134) : AC(34)
Pharmacological Actions : Epidermal growth factor receptor (EGFR) inhibitor : CK(27) : AC(22)

Curcumin exhibits anticarcinogenic and anti-inflammatory properties.

Pubmed Data : Arterioscler Thromb Vasc Biol. 1997 Dec;17(12):3406-13. PMID: 9437186
Article Published Date : Dec 01, 1997
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Cancers: All : CK(9062) : AC(2869), Inflammation : CK(1077) : AC(363), Lipopolysaccharide-Induced Toxicity : CK(227) : AC(128)
Pharmacological Actions : Epidermal growth factor receptor (EGFR) inhibitor : CK(27) : AC(22), NF-kappaB Inhibitor : CK(595) : AC(401), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Curcumin has anti-pancreatic and lung cancer activity.

Pubmed Data : Anticancer Res. 2006 Nov-Dec;26(6B):4423-30. PMID: 17201164
Article Published Date : Nov 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Lung Cancer : CK(496) : AC(198), Pancreatic Cancer : CK(530) : AC(168)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Cyclooxygenase 2 Inhibitors : CK(269) : AC(169), Epidermal growth factor receptor (EGFR) inhibitor : CK(27) : AC(22)

Curcumin has therapeutic potential in prostate cancer.

Pubmed Data : Mol Urol. 2000;4(1):1-6. PMID: 10851300
Article Published Date : Jan 01, 2000
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Prostate Cancer : CK(998) : AC(288)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Epidermal growth factor receptor (EGFR) inhibitor : CK(27) : AC(22)

Curcumin induces apoptosis of triple-negative breast cancer cells.

Pubmed Data : Mol Med Report. 2012 Sep 26. Epub 2012 Sep 26. PMID: 23023821
Article Published Date : Sep 25, 2012
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Breast Cancer: Triple Negative : CK(61) : AC(13)
Pharmacological Actions : apoptosis, Epidermal growth factor receptor (EGFR) inhibitor : CK(27) : AC(22)

Curcumin inhibits epidermal growth factor receptor activity in human epidermoid cancer cells.

Pubmed Data : Biochim Biophys Acta. 1994 Dec 30;1224(3):597-600. PMID: 7803521
Article Published Date : Dec 30, 1994
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Skin Cancer : CK(417) : AC(171), Squamous cell carcinoma : CK(79) : AC(36)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Epidermal growth factor receptor (EGFR) inhibitor : CK(27) : AC(22)

Curcumin inhibits human colon cancer cell growth.

Pubmed Data : Oncogene. 2006 Jan 12;25(2):278-87. PMID: 16170359
Article Published Date : Jan 12, 2006
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Colon Cancer : CK(895) : AC(233)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1052) : AC(775), Epidermal growth factor receptor (EGFR) inhibitor : CK(27) : AC(22)

Curcumin inhibits ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation associated with tumor cell growth.

Pubmed Data : Carcinogenesis. 1995 Aug;16(8):1741-5. PMID: 7634398
Article Published Date : Aug 01, 1995
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Tumors : CK(197) : AC(110)
Pharmacological Actions : Anti-Tumor : CK(69) : AC(44), Antiproliferative : CK(1052) : AC(775), Epidermal growth factor receptor (EGFR) inhibitor : CK(27) : AC(22)

Curcumin may provide an ideal therapy to down-regulate epidermal growth factor receptor activity.

Pubmed Data : J Mol Recognit. 2012 Nov ;25(11):623-9. PMID: 23108622
Article Published Date : Oct 31, 2012
Study Type : Review
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Cancers: All : CK(9062) : AC(2869)
Pharmacological Actions : Epidermal growth factor receptor (EGFR) inhibitor : CK(27) : AC(22)

Curcumin suppresses transcription factor Egr-1.

Pubmed Data : Thromb Res. 2000 Feb 15;97(4):179-89. PMID: 10674404
Article Published Date : Feb 15, 2000
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Pharmacological Actions : Epidermal growth factor receptor (EGFR) inhibitor : CK(27) : AC(22)

EGCG exhibits anti-cancer activity against tamoxifen-resistant breast cancer lines.

Pubmed Data : Biosci Rep. 2011 Apr ;31(2):99-108. PMID: 20446926
Article Published Date : Apr 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Catechin : CK(403) : AC(130)
Diseases : Breast Cancer : CK(2354) : AC(621), Cancer Metastasis : CK(272) : AC(135), Cancers: Drug Resistant : CK(225) : AC(147)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Epidermal growth factor receptor (EGFR) inhibitor : CK(27) : AC(22), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71)
Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57), Tamoxifen Resistance : CK(3) : AC(3)

Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy.

Pubmed Data : J Natl Cancer Inst. 2008 May 7 ;100(9):672-9. Epub 2008 Apr 29. PMID: 18445819
Article Published Date : May 06, 2008
Study Type : In Vitro Study
Additional Links
Diseases : Breast Cancer : CK(2354) : AC(621), Cancer Stem Cells : CK(988) : AC(42), Cancers: Drug Resistant : CK(225) : AC(147)
Pharmacological Actions : Epidermal growth factor receptor (EGFR) inhibitor : CK(27) : AC(22)
Anti Therapeutic Actions : Chemotherapy : CK(257) : AC(38)
Problem Substances : Chemotherapy : CK(348) : AC(44)

Resveratrol inhibits EGF-induced invasion of human lung cancer cells.

Pubmed Data : Zhongguo Fei Ai Za Zhi. 2010 Apr;13(4):287-91. PMID: 20677551
Article Published Date : Apr 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol : CK(977) : AC(590)
Diseases : Cancer Metastasis : CK(272) : AC(135), Lung Cancer : CK(496) : AC(198)
Pharmacological Actions : Anti-metastatic : CK(192) : AC(115), Anticarcinogenic Agents : CK(521) : AC(275), Epidermal growth factor receptor (EGFR) inhibitor : CK(27) : AC(22)
Additional Keywords : Stilbenes : CK(402) : AC(242)

Resveratrol may have value as a potential adjunctive treatment for late-stage hormone refractory prostate cancer.

Pubmed Data : Hum Mol Genet. 2010 Nov 15;19(22):4319-29. Epub 2010 Aug 20. PMID: 20729295
Article Published Date : Nov 15, 2010
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol : CK(977) : AC(590)
Diseases : Prostate Cancer : CK(998) : AC(288)
Pharmacological Actions : Anti-Androgen : CK(58) : AC(15), Antiproliferative : CK(1052) : AC(775), Cell cycle arrest : CK(390) : AC(319), Epidermal growth factor receptor (EGFR) inhibitor : CK(27) : AC(22)
Additional Keywords : Drug Synergy : CK(327) : AC(147), Stilbenes : CK(402) : AC(242)

Silibinin prevents the EGFR signaling pathway and may be used as an effective drug for the inhibition of metastasis of human breast cancer.

Pubmed Data : Anticancer Res. 2011 Nov ;31(11):3767-73. PMID: 22110198
Article Published Date : Nov 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Silibinin : CK(58) : AC(10)
Diseases : Breast Cancer : CK(2354) : AC(621), Breast Cancer: Metastatic : CK(82) : AC(33), Cancer Metastasis : CK(272) : AC(135)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Epidermal growth factor receptor (EGFR) inhibitor : CK(27) : AC(22), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71)

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