Gastroprotective

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View the Evidence: Pharmacological Actions

"Aspirin's ability to induce intestinal injury in rats is dependent on bile and can be reversed if pre-associated with phosphatidylcholine."

Pubmed Data : J Physiol Pharmacol. 2011 Aug ;62(4):491-6. PMID: 22100851
Article Published Date : Aug 01, 2011
Study Type : Animal Study
Additional Links
Substances : Phosphatidylcholine : CK(101) : AC(22)
Diseases : Aspirin-Induced Toxicity : CK(83) : AC(24)
Pharmacological Actions : Gastroprotective : CK(62) : AC(31)
Problem Substances : Aspirin : CK(471) : AC(64)

Angelica sinensis promotes ulcer healing.

Pubmed Data : Radiat Res. 2006 May;165(5):546-52. PMID: 12493573
Article Published Date : May 01, 2006
Study Type : Animal Study
Additional Links
Substances : Angelica : CK(67) : AC(25)
Diseases : Duodenal Ulcer : CK(89) : AC(26), Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions : Gastroprotective : CK(62) : AC(31)

Astaxanthin protects against gastric ulcer formation.

Pubmed Data : Phytother Res. 2011 Dec 14. Epub 2011 Dec 14. PMID: 22170791
Article Published Date : Dec 14, 2011
Study Type : Animal Study
Additional Links
Substances : Astaxanthin : CK(353) : AC(117)
Diseases : Alcohol Toxicity : CK(212) : AC(85), Aspirin-Induced Toxicity : CK(83) : AC(24), Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57), Gastroprotective : CK(62) : AC(31)

Banana powder strengthens mucosal resistance and promotes the healing of ulcers.

Pubmed Data : J Ethnopharmacol. 1987 Sep-Oct;21(1):11-9. PMID: 2447444
Article Published Date : Sep 01, 1987
Study Type : Animal Study
Additional Links
Substances : Banana : CK(123) : AC(36)
Diseases : Aspirin-Induced Toxicity : CK(83) : AC(24), Gastric Ulcer : CK(246) : AC(91), Peptic Ulcer : CK(454) : AC(110)
Pharmacological Actions : Gastroprotective : CK(62) : AC(31)

Bay leaf extract has gastroprotective and antioxidant properties.

Pubmed Data : J Med Food. 2011 Feb 11. Epub 2011 Feb 11. PMID: 21314364
Article Published Date : Feb 11, 2011
Study Type : Animal Study
Additional Links
Substances : Bay leaf : CK(55) : AC(27)
Diseases : Gastric Ulcer : CK(246) : AC(91), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Carminative : CK(12) : AC(2), Gastroprotective : CK(62) : AC(31), Stomachic : CK(2) : AC(1)

Bay leaf seeds have gastroprotective effects against ethanol induced gastric ulcer.

Pubmed Data : J Ethnopharmacol. 1997 Sep;58(1):9-14. PMID: 9323999
Article Published Date : Sep 01, 1997
Study Type : Animal Study
Additional Links
Substances : Bay leaf : CK(55) : AC(27)
Diseases : Alcohol Toxicity : CK(212) : AC(85), Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57), Gastroprotective : CK(62) : AC(31)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Bifidobacterium bifidum has a protective effect against gastric injury.

Pubmed Data : J Dairy Sci. 2012 Nov 28. Epub 2012 Nov 28. PMID: 23200466
Article Published Date : Nov 27, 2012
Study Type : Animal Study
Additional Links
Substances : Bifidobacterium Bifidum : CK(50) : AC(5)
Diseases : Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions : Gastroprotective : CK(62) : AC(31)

Curcumin exhibits anti-bacterial activity against Helicobacter pylori infection.

Pubmed Data : Antimicrob Agents Chemother. 2009 Apr;53(4):1592-7. Epub 2009 Feb 9. PMID: 19204190
Article Published Date : Apr 01, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Helicobacter Pylori Infection : CK(305) : AC(61)
Pharmacological Actions : Anti-Bacterial Agents : CK(970) : AC(316), Gastroprotective : CK(62) : AC(31)

Curcumin exhibits anti-gastrointestinal cancer activity in rats.

Pubmed Data : Cancer Sci. 2006 Sep;97(9):896-904. Epub 2006 Jun 29. PMID: 16805852
Article Published Date : Sep 01, 2006
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Gastric Cancer : CK(373) : AC(111), Gastrointestinal Cancer : CK(43) : AC(11)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Chemopreventive : CK(1528) : AC(382), Gastroprotective : CK(62) : AC(31)

Curcumin has anti-ulcer activity in experimental gastric ulcer in rats.

Pubmed Data : Biomed Environ Sci. 2009 Dec;22(6):488-95. PMID: 20337222
Article Published Date : Dec 01, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Gastric Ulcer : CK(246) : AC(91), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57), Antioxidants : CK(3653) : AC(1318), Gastroprotective : CK(62) : AC(31), Interleukin-6 Downregulation : CK(470) : AC(135)

Curcumin prevents glandular stomach cancer in rats.

Pubmed Data : Anticancer Res. 2001 Sep-Oct;21(5):3407-11. PMID: 11848501
Article Published Date : Sep 01, 2001
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Gastric Cancer : CK(373) : AC(111)
Pharmacological Actions : Chemopreventive : CK(1528) : AC(382), Gastroprotective : CK(62) : AC(31)

Curcumin protects against indomethacin-induced gastric injury.

Pubmed Data : Anticancer Drugs. 2009 Oct;20(9):757-69. PMID: 16631530
Article Published Date : Oct 01, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Drug-Induced Toxicity: Indomethacin : CK(15) : AC(7), Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions : Gastroprotective : CK(62) : AC(31)
Additional Keywords : Drug: Indomethacin : CK(30) : AC(17)

Curcumin protects intestinal mucosal barrier function of rat enteritis.

Pubmed Data : PLoS One. 2010;5(9):e12969. Epub 2010 Sep 24. PMID: 20885979
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Intestinal Permeability : CK(224) : AC(53)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Antioxidants : CK(3653) : AC(1318), Gastroprotective : CK(62) : AC(31)

Curcumin's antiulcer activity is primarily attributed to MMP-9 inhibition, one of the major path-ways of ulcer healing.

Pubmed Data : J Biol Chem. 2005 Mar 11;280(10):9409-15. Epub 2004 Dec 22. PMID: 15615723
Article Published Date : Mar 11, 2005
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Gastric Ulcer : CK(246) : AC(91), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57), Gastroprotective : CK(62) : AC(31), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(49) : AC(30)
Additional Keywords : Drug: Indomethacin : CK(30) : AC(17)

Earthworm paste has gastroprotective properties and is superior to the drug ranitidine in preventing experimentally induced gastric ulcer.

Pubmed Data : Eur Rev Med Pharmacol Sci. 2010 Mar;14(3):171-6. PMID: 20391954
Article Published Date : Mar 01, 2010
Study Type : Animal Study
Additional Links
Substances : Earthworms : CK(6) : AC(3)
Diseases : Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57), Gastroprotective : CK(62) : AC(31)
Additional Keywords : Science Confirms Tradition : CK(72) : AC(49), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Ellagic acid and pumpkin seed oil protects against methotrexate-induced small intestine damage in rats.

Pubmed Data : Indian J Biochem Biophys. 2011 Dec ;48(6):380-7. PMID: 22329239
Article Published Date : Nov 30, 2011
Study Type : Animal Study
Additional Links
Substances : Ellagic Acid : CK(77) : AC(40), Pumpkin Seed Oil/Meal : CK(48) : AC(11)
Diseases : Drug Toxicity: Methotrexate : CK(30) : AC(13), Gastrointestinal Hemorrhage : CK(33) : AC(4)
Pharmacological Actions : Gastroprotective : CK(62) : AC(31)

Ginkgo biloba extract can increase anti-oxidative activity and inhibit the progression of gastric precancerous lesions.

Pubmed Data : J Dig Dis. 2009 Nov;10(4):293-9. PMID: 19906108
Article Published Date : Nov 01, 2009
Study Type : Animal Study
Additional Links
Substances : Ginkgo biloba : CK(512) : AC(97)
Diseases : Gastric Cancer : CK(373) : AC(111)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Gastroprotective : CK(62) : AC(31)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Green mussel extract exhibits anti-inflammatory and gastroprotective properties.

Pubmed Data : Arzneimittelforschung. 1980;30(12):2128-32. PMID: 7194074
Article Published Date : Jan 01, 1980
Study Type : Animal Study
Additional Links
Substances : Mussel: Green-lipped (Perna canaliculus) : CK(48) : AC(20)
Diseases : Aspirin-Induced Toxicity : CK(83) : AC(24), Drug-Induced Toxicity: Indomethacin : CK(15) : AC(7), Gastric Ulcer : CK(246) : AC(91), NSAID-induced toxicity : CK(230) : AC(50)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Gastroprotective : CK(62) : AC(31)
Additional Keywords : Drug: Indomethacin : CK(30) : AC(17)

Honey and a glucose-fructose-sucrose-maltose mixture against ethanol-, indomethacin-, and acidified aspirin-induced lesions in the rat.

Pubmed Data : Exp Toxicol Pathol. 2002 Nov;54(3):217-21. PMID: 12484559
Article Published Date : Nov 01, 2002
Study Type : Animal Study
Additional Links
Substances : Fructose : CK(4) : AC(2), Glucose : CK(12) : AC(2), Honey : CK(251) : AC(50), Maltose : CK(2) : AC(1), Sucrose : CK(12) : AC(2)
Diseases : Alcohol Toxicity : CK(212) : AC(85), Aspirin-Induced Toxicity : CK(83) : AC(24), Gastric Ulcer : CK(246) : AC(91), NSAID-induced toxicity : CK(230) : AC(50)
Pharmacological Actions : Gastroprotective : CK(62) : AC(31)
Additional Keywords : Drug: Indomethacin : CK(30) : AC(17)

Loquat seed extract and deep sea water protect against NSAID-induced gastric injury in rats.

Pubmed Data : J Nat Med. 2011 Jan;65(1):9-17. Epub 2010 Jul 17. PMID: 20640522
Article Published Date : Jan 01, 2011
Study Type : Animal Study
Additional Links
Substances : Loquat Seeds : CK(11) : AC(6), Water: Deep Sea : CK(21) : AC(7)
Diseases : Drug-Induced Toxicity: Indomethacin : CK(15) : AC(7), NSAID-induced toxicity : CK(230) : AC(50)
Pharmacological Actions : Gastroprotective : CK(62) : AC(31)
Additional Keywords : Drug: Indomethacin : CK(30) : AC(17), Plant Extracts : CK(3572) : AC(1216)

Melatonin and curcumin protect against ndomethacin-induced acute gastric ulceration.

Pubmed Data : Free Radic Biol Med. 2006 Sep 15;41(6):911-25. Epub 2006 Apr 30. PMID: 16934674
Article Published Date : Sep 15, 2006
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482), Melatonin : CK(470) : AC(131)
Diseases : Drug-Induced Toxicity: Indomethacin : CK(15) : AC(7), Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Gastroprotective : CK(62) : AC(31), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71)
Additional Keywords : Drug: Indomethacin : CK(30) : AC(17)

Moringa oleifera protects against ulcer formation by modulating serotonin.

Pubmed Data : Drug Alcohol Depend. 1994 Feb;34(3):225-9. PMID: 20637582
Article Published Date : Feb 01, 1994
Study Type : Animal Study
Additional Links
Substances : Moringa oleifera : CK(59) : AC(29)
Diseases : Duodenal Ulcer : CK(89) : AC(26), Peptic Ulcer : CK(454) : AC(110)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57), Gastroprotective : CK(62) : AC(31), Serotonergic : CK(32) : AC(8)

Pomegranate extract protects against alcohol and aspirin-induced gastric mucosal injury.

Pubmed Data : J Ethnopharmacol. 2005 Jan 4;96(1-2):171-6. PMID: 15588667
Article Published Date : Jan 04, 2005
Study Type : Animal Study
Additional Links
Substances : Pomegranate : CK(146) : AC(61)
Diseases : Alcohol Toxicity : CK(212) : AC(85), Aspirin-Induced Toxicity : CK(83) : AC(24), Gastric Ulcer : CK(246) : AC(91), NSAID-induced toxicity : CK(230) : AC(50), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57), Antioxidants : CK(3653) : AC(1318), Gastroprotective : CK(62) : AC(31)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Sesamol attenuates diclofenac-induced acute gastric mucosal injury.

Pubmed Data : Shock. 2008 Oct ;30(4):456-62. PMID: 18277948
Article Published Date : Oct 01, 2008
Study Type : Animal Study
Additional Links
Substances : Sesamol : CK(79) : AC(30)
Diseases : Gastric Ulcer : CK(246) : AC(91), Inflammation : CK(1077) : AC(363), Lipid Peroxidation : CK(403) : AC(127), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Antioxidants : CK(3653) : AC(1318), Cyclooxygenase Inhibitors : CK(64) : AC(32), Gastroprotective : CK(62) : AC(31)
Problem Substances : Diclofenac : CK(72) : AC(7)
Adverse Pharmacological Actions : Irritant : CK(49) : AC(9)

The medicinal mushroom Ganoderma lucidum (Reishi) accelerates healing of acetic acid-induced ulcers in rats.

Pubmed Data : J Med Food. 2004 Winter;7(4):417-21. PMID: 15671683
Article Published Date : Dec 01, 2004
Study Type : Animal Study
Additional Links
Substances : Reishi Mushroom : CK(114) : AC(46)
Diseases : Duodenal Ulcer : CK(89) : AC(26), Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions : Gastroprotective : CK(62) : AC(31)

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