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Article Count - 272
Cumulative Knowledge - 567

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View the Evidence: Pharmacological Actions

A multivitamin and phospholipids complex protects the hepatic cells from androgenic-anabolic-steroids-induced toxicity.

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Pubmed Data : Clin Toxicol (Phila). 2008 Jan;46(1):57-66. PMID: 17852158

Article Published Date : Jan 01, 2008

Study Type : Human Study

Additional Links

Substances : Multivitamin : CK(243) : AC(22)

Diseases : Androgen-Induced Diseases : CK(49) : AC(20), Steroid-Induced Toxicity: Androgenic-Anabolic steroids : CK(12) : AC(2)

Pharmacological Actions : Hepatoprotective : CK(557) : AC(272)

A probiotic yogurt demonstrates a significant rate of minimal hepatic encephalopathy reversal.

Click here to read the entire abstract

Pubmed Data : Am J Gastroenterol. 2008 Jul;103(7):1707-15. PMID: 18691193

Article Published Date : Jul 01, 2008

Study Type : Human Study

Additional Links

Substances : Probiotics : CK(2468) : AC(245)

Diseases : Hepatic Encephalopathy : CK(44) : AC(9), Liver Cirrhosis : CK(216) : AC(32), Liver Cirrhosis: Alcoholic : CK(33) : AC(5)

Pharmacological Actions : Hepatoprotective : CK(557) : AC(272)

Additional Keywords : Disease Reversal : CK(42) : AC(10)

A vitamin K2 preparation inhibits the development of liver cancer in patients with type C cirrhosis.

Click here to read the entire abstract

Pubmed Data : Hepatogastroenterology. 2010 Sep-Oct;57(102-103):1264-7. PMID: 21410069

Article Published Date : Sep 01, 2010

Study Type : Human Study

Additional Links

Substances : Menatetrenone : CK(10) : AC(1), Vitamin K2 : CK(277) : AC(32), Vitamin K2: Menaquinones (MK-4-14) : CK(149) : AC(19)

Diseases : Liver Cancer : CK(1641) : AC(266), Liver Cirrhosis : CK(216) : AC(32)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Hepatoprotective : CK(557) : AC(272)

Curcuma longa (turmeric) and tinospora cordifolia (guduchi) prevents antibiotic-induced liver damage in patients with tubercolosis.

Click here to read the entire abstract

Pubmed Data : World J Gastroenterol. 2008 Aug 14;14(30):4753-62.PMID:18720535

Article Published Date : Aug 14, 2008

Study Type : Human Study

Additional Links

Substances : Guduchi : CK(32) : AC(4), Turmeric : CK(2995) : AC(1585)

Diseases : Pulmonary Tubercolosis : CK(80) : AC(12), Tubercolosis: Latent : CK(51) : AC(6), Tubercolosis Drug Induced Toxicity : CK(26) : AC(9), Tuberculosis : CK(255) : AC(44)

Pharmacological Actions : Antitubercular Agents : CK(12) : AC(3), Hepatoprotective : CK(557) : AC(272)

Additional Keywords : Ethambutol : CK(10) : AC(1), Isoniazid : CK(10) : AC(1), Pyrazinamide : CK(10) : AC(1), Rifampicin : CK(10) : AC(1)

Curcumin alleviates ethanol-induced oxidative damage in liver cells.

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2010 Jan 18. Epub 2010 Jan 18. PMID: 20080166

Article Published Date : Jan 18, 2010

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Alcohol Toxicity : CK(212) : AC(85), Alcoholic Liver Disease : CK(146) : AC(50)

Pharmacological Actions : Hepatoprotective : CK(557) : AC(272)

N-acetyl cysteine may have a protective effect against reperfusion injury in liver transplant recipients.

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Pubmed Data : Transplant Proc. 2008 Nov;40(9):2978-80. PMID: 19010165

Article Published Date : Nov 01, 2008

Study Type : Human Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine) : CK(264) : AC(62)

Diseases : Organ Transplantation: Liver : CK(202) : AC(24)

Pharmacological Actions : Hepatoprotective : CK(557) : AC(272)

"Vitamin E protects against oxidative damage caused by formaldehyde in the liver and plasma of rats."

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Pubmed Data : Mol Cell Biochem. 2006 Oct ;290(1-2):61-7. Epub 2006 Aug 26. PMID: 16937016

Article Published Date : Oct 01, 2006

Study Type : Animal Study

Additional Links

Substances : Vitamin E : CK(1285) : AC(221)

Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Formaldehyde Toxicity : CK(4) : AC(2), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Hepatoprotective : CK(557) : AC(272)

Problem Substances : Formaldehyde : CK(19) : AC(10)

6-gingerol, an active ingredient of ginger, protects acetaminophen-induced liver damage in mice.

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Pubmed Data : Zhong Xi Yi Jie He Xue Bao. 2011 Nov ;9(11):1264-9. PMID: 22088594

Article Published Date : Nov 01, 2011

Study Type : Animal Study

Additional Links

Substances : Gingerol : CK(4) : AC(2)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(100) : AC(26), Liver Damage: Drug-Induced : CK(46) : AC(10)

Pharmacological Actions : Hepatoprotective : CK(557) : AC(272)

A curcumin-phospholipid complex works synergistically to protect the livers of rats following chemical exposure.

Click here to read the entire abstract

Pubmed Data : Int J Pharm. 2007 Feb 7;330(1-2):155-63. Epub 2006 Sep 23. PMID: 17112692

Article Published Date : Feb 07, 2007

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482), Phosphatidylcholine : CK(101) : AC(22)

Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175)

Pharmacological Actions : Hepatoprotective : CK(557) : AC(272)

A flax and pumpkin seed mixture has anti-atherogenic and hepatoprotective effects.

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Pubmed Data : Food Chem Toxicol. 2008 Dec;46(12):3714-20. Epub 2008 Oct 1. PMID: 18938206

Article Published Date : Dec 01, 2008

Study Type : Animal Study

Additional Links

Substances : Flaxseed : CK(275) : AC(57), Omega-3 Fatty Acids : CK(3333) : AC(319), Pumpkin Seed Oil/Meal : CK(48) : AC(11)

Diseases : Arteriosclerosis : CK(2154) : AC(123), High Cholesterol : CK(1718) : AC(198)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Hepatoprotective : CK(557) : AC(272)

A krill oil supplemented diet suppresses hepatic steatosis in high-fat fed rats.

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Pubmed Data : PLoS One. 2012 ;7(6):e38797. Epub 2012 Jun 7. PMID: 22685607

Article Published Date : Jan 01, 2012

Study Type : Animal Study

Additional Links

Substances : Krill : CK(101) : AC(20)

Diseases : Fatty Liver : CK(493) : AC(122), Insulin: Elevated : CK(186) : AC(41), Triglycerides: Elevated : CK(340) : AC(65)

Pharmacological Actions : Hepatoprotective : CK(557) : AC(272)

A polyphenol extract from red grapes redues fat content in an animal model of non-alcoholic liver disease.

Click here to read the entire abstract

Pubmed Data : Br J Nutr. 2010 Dec;104(12):1760-70. Epub 2010 Aug 2. PMID: 20673376

Article Published Date : Dec 01, 2010

Study Type : Animal Study

Additional Links

Substances : Flavonoids : CK(909) : AC(289), Grape : CK(998) : AC(274), Polyphenols : CK(427) : AC(174), Resveratrol : CK(977) : AC(590)

Diseases : Fatty Liver : CK(493) : AC(122)

Pharmacological Actions : Hepatoprotective : CK(557) : AC(272)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Ajwain attenuates chemically-induced liver damage in rats.

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2009 Feb;47(2):279-82. Epub 2008 Oct 4. PMID: 18940228

Article Published Date : Feb 01, 2009

Study Type : Animal Study

Additional Links

Substances : Ajwain : CK(4) : AC(3)

Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Hepatoprotective : CK(557) : AC(272)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Almond skin extract has hepatoprotective properties against chemically-induced liver cell damage.

Click here to read the entire abstract

Pubmed Data : Chem Biol Interact. 2010 Apr 29;185(2):101-9. Epub 2010 Mar 6. PMID: 20211157

Article Published Date : Apr 29, 2010

Study Type : Animal Study

Additional Links

Substances : Almond : CK(107) : AC(15), Catechin : CK(403) : AC(130)

Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Hepatoprotective : CK(557) : AC(272)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Aloe has a protective effect against petroleum product hepatotoxicity and genotoxicity in mice.

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2009 Oct;47(10):2454-7. Epub 2009 Jul 5. PMID: 19583991

Article Published Date : Oct 01, 2009

Study Type : Animal Study

Additional Links

Substances : Aloe Vera : CK(201) : AC(44)

Diseases : DNA damage : CK(711) : AC(293), Petroleum Exposure And Toxicity : CK(49) : AC(18)

Pharmacological Actions : Hepatoprotective : CK(557) : AC(272)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Aloe vera has a protective effect against lindane induced hepatotoxicity and genotoxicity.

Click here to read the entire abstract

Pubmed Data : Pak J Pharm Sci. 2006 Oct;19(4):337-40. PMID: 17105716

Article Published Date : Oct 01, 2006

Study Type : Animal Study

Additional Links

Substances : Aloe Vera : CK(201) : AC(44)

Diseases : Pesticide Toxicity : CK(147) : AC(45)

Pharmacological Actions : Hepatoprotective : CK(557) : AC(272)

Additional Keywords : Chemical: Lindane : CK(22) : AC(7), Plant Extracts : CK(3572) : AC(1216)

Alpha lipoic may have potential clinical applications for the treatment or prevention of hypertriglyceridemia and diabetic dyslipidemia.

Click here to read the entire abstract

Pubmed Data : Arch Biochem Biophys. 2009 May 1;485(1):63-71. Epub 2009 Feb 20. PMID: 19232511

Article Published Date : May 01, 2009

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid : CK(384) : AC(82)

Diseases : Diabetes: Cardiovascular Illness : CK(666) : AC(104), Hyperlipidemia : CK(1211) : AC(109), Triglycerides: Elevated : CK(340) : AC(65)

Pharmacological Actions : Hepatoprotective : CK(557) : AC(272)

Alpha lipoic may inhibit the development and progression of fatty liver.

Click here to read the entire abstract

Pubmed Data : Biochem Biophys Res Commun. 2010 Mar 12;393(3):536-41. Epub 2010 Feb 12. PMID: 20153726

Article Published Date : Mar 12, 2010

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid : CK(384) : AC(82)

Diseases : Fatty Liver : CK(493) : AC(122)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Hepatoprotective : CK(557) : AC(272)

Amla exhibits antihyperglycemic and hepato-renal protective properties in fluoride induced toxicity.

Click here to read the entire abstract

Pubmed Data : J Pharm Bioallied Sci. 2012 Jul ;4(3):250-4. PMID: 22923969

Article Published Date : Jun 30, 2012

Study Type : Animal Study

Additional Links

Substances : Amla Fruit : CK(51) : AC(28)

Diseases : Fluoride Toxicity : CK(146) : AC(40)

Pharmacological Actions : Hepatoprotective : CK(557) : AC(272), Hypoglycemic Agents : CK(563) : AC(156), Renoprotective : CK(191) : AC(90)

Problem Substances : Fluoride : CK(264) : AC(45)

Andrographolide, a compound found within andrographis, has anti-tumor activity in chemically-induced liver damage.

Click here to read the entire abstract

Pubmed Data : Nutrition. 2005 Jun;21(6):756-61. PMID: 19679627

Article Published Date : Jun 01, 2005

Study Type : Animal Study

Additional Links

Substances : Andrographis : CK(81) : AC(35)

Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Liver Cancer : CK(1641) : AC(266), Pesticide Toxicity : CK(147) : AC(45)

Pharmacological Actions : Hepatoprotective : CK(557) : AC(272)

Antioxidant therapy probects against non-alcoholic fatty liver disease.

Click here to read the entire abstract

Pubmed Data : Med Hypotheses. 2011 Jul 15. Epub 2011 Jul 15. PMID: 21764223

Article Published Date : Jul 15, 2011

Study Type : Animal Study

Additional Links

Substances : Astaxanthin : CK(353) : AC(117), Spirulina : CK(75) : AC(21)

Diseases : Fatty Liver : CK(493) : AC(122)

Pharmacological Actions : Hepatoprotective : CK(557) : AC(272)

Antrodia camphorata protects livers against damage associated with chronic alcohol consumption.

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2010 Mar 1. Epub 2010 Mar 1. PMID: 20192205

Article Published Date : Mar 01, 2010

Study Type : Animal Study

Additional Links

Substances : Antrodia camphorata : CK(7) : AC(4)

Diseases : Alcohol Toxicity : CK(212) : AC(85), Alcoholic Liver Disease : CK(146) : AC(50)

Pharmacological Actions : Hepatoprotective : CK(557) : AC(272)

Apigenin has a protective role against lipid peroxidation and oxidative stress associated with the development of liver cancer in rats.

Click here to read the entire abstract

Pubmed Data : Atherosclerosis. 2009 Dec;207(2):420-7. Epub 2009 May 22. PMID: 15185843

Article Published Date : Dec 01, 2009

Study Type : Animal Study

Additional Links

Substances : Apigenin : CK(76) : AC(51), Flavonoids : CK(909) : AC(289)

Diseases : Liver Cancer : CK(1641) : AC(266)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Hepatoprotective : CK(557) : AC(272)

Apricot (Prunus armeniaca L.) has a protective effect against fatty liver and damage induced by carbon tetrachloride in Wistar rats.

Click here to read the entire abstract

Pubmed Data : Br J Nutr. 2009 Dec;102(12):1767-75. PMID: 19822030

Article Published Date : Dec 01, 2009

Study Type : Animal Study

Additional Links

Substances : Apricot : CK(12) : AC(6)

Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Fatty Liver : CK(493) : AC(122), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Hepatoprotective : CK(557) : AC(272)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Ashwaganda's hepatoprotective properties protects against iron overload toxicity.

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2000 Nov;14(7):568-70. PMID: 11054855

Article Published Date : Nov 01, 2000

Study Type : Animal Study

Additional Links

Substances : Ashwagandha : CK(137) : AC(63)

Diseases : Iron Overload : CK(59) : AC(13)

Pharmacological Actions : Hepatoprotective : CK(557) : AC(272)

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Groundbreaking new research published in the Journal of the Medical Association of Thailand found that curcumin, the primary polyphenol in turmeric, is capable of repairing and even regenerating the liver tissues of diabetic rats.

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