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Interleukin-6 Downregulation
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Additional Topics Details for this Page
Article Count
- 135
Cumulative Knowledge
- 482
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Quick Summary: Current access displays 2 out of 88 associated Substances
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View the Evidence: Pharmacological Actions
A standardized preparation of curcuminoids compares favorably with atorvastatin on endothelial dysfunction in association with reductions in inflammatory cytokines and markers of oxidative stress.
Click here to read the entire abstract
Pubmed Data
: Drugs R D. 2008;9(4):243-50. PMID:
18588355
Article Published Date
: Jan 01, 2008
Study Type
: Human Study
Additional Links
Substances
:
Curcumin : CK(2910) : AC(1482)
Diseases
:
Endothelial Dysfunction : CK(897) : AC(173)
,
Inflammation : CK(1077) : AC(363)
,
Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions
:
Interleukin-6 Downregulation : CK(470) : AC(135)
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)
Additional Keywords
:
Drug: Atorvastatin : CK(10) : AC(1)
,
Natural Substances Versus Drugs : CK(988) : AC(165)
,
Statin Alternatives : CK(34) : AC(4)
Active polymyalgia rheumatica is characterized by increased serum levels of Interleukin-6 probably originating in inflamed tissue.
Click here to read the entire abstract
Pubmed Data
: 1: Ann Rheum Dis. 2009 Mar 1. PMID:
19254903
Article Published Date
: Mar 01, 2009
Study Type
: Human Study
Additional Links
Diseases
:
Polymyalgia Rheumatica : CK(63) : AC(7)
Pharmacological Actions
:
Interleukin-6 Downregulation : CK(470) : AC(135)
Adherence to the mediterranean diet is inversely associated with inflammation (circulating interleukin-6) among middle-aged men.
Click here to read the entire abstract
Pubmed Data
: Circulation. 2008 Jan 15;117(2):169-75. Epub 2007 Dec 17. PMID:
18086924
Article Published Date
: Jan 15, 2008
Study Type
: Human Study
Additional Links
Diseases
:
C-Reactive Protein : CK(819) : AC(74)
,
Cardiovascular Diseases : CK(5138) : AC(641)
,
Inflammation : CK(1077) : AC(363)
Therapeutic Actions
:
Dietary Modification: Mediterranean Diet : CK(500) : AC(58)
Pharmacological Actions
:
Interleukin-6 Downregulation : CK(470) : AC(135)
Additional Keywords
:
Inverse Relationship : CK(40) : AC(4)
An elemental diet reduces mucosal inflammation in patients with active Crohn's disease with remission occuring in 71% of patients.
Click here to read the entire abstract
Pubmed Data
: Inflamm Bowel Dis. 2005 Jun;11(6):580-8. PMID:
15905706
Article Published Date
: Jun 01, 2005
Study Type
: Human Study
Additional Links
Diseases
:
Inflammation : CK(1077) : AC(363)
Therapeutic Actions
:
Dietary Modification: Elemental Diet : CK(145) : AC(17)
Pharmacological Actions
:
Interleukin-1 receptor antagonist : CK(11) : AC(2)
,
Interleukin-6 Downregulation : CK(470) : AC(135)
,
Interleukin-8 downregulation : CK(97) : AC(28)
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)
Association of endodontic infection with detection of an initial lesion to the cardiovascular system.
Click here to read the entire abstract
Pubmed Data
: J Endod. 2011 Dec ;37(12):1624-9. PMID:
22099894
Article Published Date
: Nov 30, 2011
Study Type
: Human Study
Additional Links
Diseases
:
Periodontal Diseases : CK(134) : AC(34)
Pharmacological Actions
:
Interleukin-6 Downregulation : CK(470) : AC(135)
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)
Astaxanthin addition improves human neutrophils function.
Click here to read the entire abstract
Pubmed Data
: Eur J Nutr. 2010 Dec;49(8):447-57. Epub 2010 Apr 2. PMID:
20361333
Article Published Date
: Dec 01, 2010
Study Type
: Human Study
Additional Links
Substances
:
Astaxanthin : CK(353) : AC(117)
Diseases
:
Immune Disorders: Low Immune Function : CK(488) : AC(115)
,
Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions
:
Antioxidants : CK(3653) : AC(1318)
,
Immunostimulatory : CK(143) : AC(33)
,
Interleukin-6 Downregulation : CK(470) : AC(135)
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)
Astragalus improves cardiac function in aged patients with Chronic Heart Failure.
Click here to read the entire abstract
Pubmed Data
: Chin J Integr Med. 2005 Sep;11(3):187-90. PMID:
16181532
Article Published Date
: Sep 01, 2005
Study Type
: Human Study
Additional Links
Substances
:
Astragalus : CK(225) : AC(49)
Diseases
:
Heart Failure : CK(711) : AC(97)
Pharmacological Actions
:
Interleukin-6 Downregulation : CK(470) : AC(135)
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)
Cashew may have anti-inflammatory activity in rheumatoid arthritis patients.
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2006 Dec 6;108(3):398-406. Epub 2006 Jun 2. PMID:
16824715
Article Published Date
: Dec 06, 2006
Study Type
: Human Study
Additional Links
Diseases
:
Lipopolysaccharide-Induced Toxicity : CK(227) : AC(128)
,
Rheumatoid Arthritis : CK(424) : AC(64)
Pharmacological Actions
:
Interleukin-1 beta downregulation : CK(177) : AC(70)
,
Interleukin-6 Downregulation : CK(470) : AC(135)
,
NF-kappaB Inhibitor : CK(595) : AC(401)
Additional Keywords
:
Plant Extracts : CK(3572) : AC(1216)
Chronic ingestion of acrylamide-containing products (potato chips) induces a proinflammatory state, a risk factor for progression of atherosclerosis.
Click here to read the entire abstract
Pubmed Data
: Am J Clin Nutr. 2009 Mar ;89(3):773-7. Epub 2009 Jan 21. PMID:
19158207
Article Published Date
: Mar 01, 2009
Study Type
: Human Study
Additional Links
Diseases
:
C-Reactive Protein : CK(819) : AC(74)
,
Cholesterol: Oxidation : CK(457) : AC(98)
,
Lipid Peroxidation : CK(403) : AC(127)
Pharmacological Actions
:
Interleukin-6 Downregulation : CK(470) : AC(135)
Problem Substances
:
Acrylamide : CK(33) : AC(3)
,
Potato : CK(43) : AC(11)
,
Potato Chips : CK(10) : AC(1)
Adverse Pharmacological Actions
:
Atherogenic : CK(21) : AC(3)
,
Inflammatory : CK(150) : AC(37)
Chronic insomnia is associated with a shift of interleukin-6 and tumor necrosis factor secretion from nighttime to daytime.
Click here to read the entire abstract
Pubmed Data
: Metabolism. 2002 Jul;51(7):887-92. PMID:
12077736
Article Published Date
: Jul 01, 2002
Study Type
: Human Study
Additional Links
Diseases
:
Insomnia : CK(471) : AC(56)
Pharmacological Actions
:
Interleukin-6 Downregulation : CK(470) : AC(135)
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)
Dietary soy improves the inflammatory and nutritional status in end-stage renal disease patients on chronic hemodialysis
Click here to read the entire abstract
Pubmed Data
: Nephrol Dial Transplant. 2006 Aug;21(8):2239-46. Epub 2006 Jun 9. PMID:
16766544
Article Published Date
: Aug 01, 2006
Study Type
: Human Study
Additional Links
Substances
:
Isoflavones : CK(627) : AC(124)
Diseases
:
C-Reactive Protein : CK(819) : AC(74)
,
Hemodialysis : CK(393) : AC(38)
,
Inflammation : CK(1077) : AC(363)
,
Kidney Failure : CK(668) : AC(41)
Pharmacological Actions
:
Interleukin-6 Downregulation : CK(470) : AC(135)
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)
Dietary supplementation with pressurized whey may potentiate the effects of exercise training on exercise tolerance and quality of life in patients with COPD.
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2010 Jun;13(3):589-98. PMID:
20521985
Article Published Date
: Jun 01, 2010
Study Type
: Human Study
Additional Links
Substances
:
Whey : CK(323) : AC(72)
Diseases
:
Athletic Performance : CK(479) : AC(61)
,
C-Reactive Protein : CK(819) : AC(74)
,
COPD : CK(158) : AC(18)
Pharmacological Actions
:
Interleukin-6 Downregulation : CK(470) : AC(135)
Electroacupuncture can effectively decrease the proinflammatory cytokine of IL-1 and IL-6 and increase the inhibition cytokine of IL-4 and IL-10 and improve the internal environment of occurrence and progression of rheumatoid arthritis.
Click here to read the entire abstract
Pubmed Data
: Zhongguo Zhen Jiu. 2010 Oct;30(10):840-4. PMID:
21058483
Article Published Date
: Oct 01, 2010
Study Type
: Human Study
Additional Links
Diseases
:
Rheumatoid Arthritis : CK(424) : AC(64)
Therapeutic Actions
:
Electroacupuncture : CK(262) : AC(34)
Pharmacological Actions
:
Interleukin-10 downregulation : CK(73) : AC(21)
,
Interleukin-4 downregulation : CK(37) : AC(12)
,
Interleukin-6 Downregulation : CK(470) : AC(135)
Electrolyzed reduced water (i.e. structured water) reduces hemodialysis-induced oxidative stress in end-stage kidney disease patients.
Click here to read the entire abstract
Pubmed Data
: Kidney Int. 2003 Aug;64(2):704-14. PMID:
12846769
Article Published Date
: Aug 01, 2003
Study Type
: Human Study
Additional Links
Substances
:
Water: Electrolyzed Reduced : CK(35) : AC(11)
Diseases
:
Hemodialysis : CK(393) : AC(38)
,
Kidney Failure : CK(668) : AC(41)
,
Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions
:
Antioxidants : CK(3653) : AC(1318)
,
Interleukin-6 Downregulation : CK(470) : AC(135)
Ginkgo is effective in treating pulmonary interstitial fibrosis.
Click here to read the entire abstract
Pubmed Data
: Zhongguo Zhong Xi Yi Jie He Za Zhi. 2005 Mar;25(3):222-4. PMID:
15842142
Article Published Date
: Mar 01, 2005
Study Type
: Human Study
Additional Links
Substances
:
Ginkgo biloba : CK(512) : AC(97)
Diseases
:
Interstitial Lung Diseases : CK(70) : AC(12)
,
Pulmonary Fibrosis : CK(135) : AC(46)
Pharmacological Actions
:
Interleukin-6 Downregulation : CK(470) : AC(135)
,
Interleukin-8 downregulation : CK(97) : AC(28)
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)
Additional Keywords
:
Natural Substances Versus Drugs : CK(988) : AC(165)
In patients with stable coronary artery disease, an independent and inverse association exists between n-3 fatty acid levels and inflammatory biomarkers.
Click here to read the entire abstract
Pubmed Data
: Atherosclerosis. 2009 Aug;205(2):538-43. Epub 2008 Dec 14. PMID:
19185299
Article Published Date
: Aug 01, 2009
Study Type
: Human Study
Additional Links
Substances
:
DHA (Docosahexaenoic Acid) : CK(582) : AC(100)
Diseases
:
C-Reactive Protein : CK(819) : AC(74)
,
Coronary Artery Disease : CK(1305) : AC(136)
,
Inflammation : CK(1077) : AC(363)
Pharmacological Actions
:
Interleukin-6 Downregulation : CK(470) : AC(135)
Increased production of Interleukin-6 is a characteristic of patients with polymyalgia rheumatica and giant cell arteritis.
Click here to read the entire abstract
Pubmed Data
: Arthritis Rheum. 1993 Sep;36(9):1286-94. PMID:
8216422
Article Published Date
: Sep 01, 1993
Study Type
: Human Study
Additional Links
Diseases
:
Giant Cell Arteritis : CK(30) : AC(3)
,
Polymyalgia Rheumatica : CK(63) : AC(7)
Pharmacological Actions
:
Interleukin-6 Downregulation : CK(470) : AC(135)
Inflammation may link obesity with asthma.
Click here to read the entire abstract
Pubmed Data
: Clin Invest Med. 2008;31(6):E373-9. Epub 2008 Dec 1. PMID:
19032908
Article Published Date
: Jan 01, 2008
Study Type
: Human Study
Additional Links
Diseases
:
Asthma : CK(918) : AC(134)
,
C-Reactive Protein : CK(819) : AC(74)
,
Inflammation : CK(1077) : AC(363)
,
Obesity : CK(1849) : AC(275)
Pharmacological Actions
:
Interleukin-6 Downregulation : CK(470) : AC(135)
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)
Additional Keywords
:
Obesity-Asthma-Inflammation Link : CK(110) : AC(17)
Lipoic acid down-regulates inflammation in multiple sclerosis patients.
Click here to read the entire abstract
Pubmed Data
: PLoS One. 2010;5(9). Epub 2010 Sep 28. PMID:
20927401
Article Published Date
: Jan 01, 2010
Study Type
: Human Study
Additional Links
Substances
:
Alpha-Lipoic Acid : CK(384) : AC(82)
Diseases
:
Brain Inflammation : CK(79) : AC(35)
,
Multiple Sclerosis : CK(716) : AC(133)
Pharmacological Actions
:
cAMP up-regulation : CK(10) : AC(1)
,
Interleukin-17 downregulation : CK(16) : AC(4)
,
Interleukin-6 Downregulation : CK(470) : AC(135)
Mastic gum has significant therapeutic value in patients with mildly to moderately active Crohns disease.
Click here to read the entire abstract
Pubmed Data
: World J Gastroenterol. 2007 Feb 7;13(5):748-53. PMID:
17278198
Article Published Date
: Feb 07, 2007
Study Type
: Human Study
Additional Links
Substances
:
Mastic gum : CK(47) : AC(9)
Diseases
:
Crohn's Disease : CK(122) : AC(22)
Pharmacological Actions
:
Interleukin-6 Downregulation : CK(470) : AC(135)
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)
Music alters constitutively expressed opiate and cytokine processes in listeners, resulting in physiological changes such as reduced blood pressure.
Click here to read the entire abstract
Pubmed Data
: Med Sci Monit. 2004 Jun;10(6):MS18-27. Epub 2004 Jun 1. PMID:
15173680
Article Published Date
: Jun 01, 2004
Study Type
: Human Study
Additional Links
Diseases
:
Hypertension : CK(2783) : AC(271)
,
Stress : CK(434) : AC(60)
Therapeutic Actions
:
Music : CK(317) : AC(33)
Pharmacological Actions
:
Interleukin-6 Downregulation : CK(470) : AC(135)
Music therapy decreased congestive heart failure in elderly patients by reducing plasma cytokine and catecholamine levels.
Click here to read the entire abstract
Pubmed Data
: Int Heart J. 2009 Jan;50(1):95-110. PMID:
19246850
Article Published Date
: Jan 01, 2009
Study Type
: Human Study
Additional Links
Diseases
:
Congestive Heart Failure : CK(256) : AC(33)
,
Elderly: Age Specific Diseases : CK(442) : AC(37)
,
Heart Failure : CK(711) : AC(97)
Therapeutic Actions
:
Music : CK(317) : AC(33)
Pharmacological Actions
:
Interleukin-6 Downregulation : CK(470) : AC(135)
Olive oil consumption has an ameliorative effect in non-alcoholic fatty liver disease.
Click here to read the entire abstract
Pubmed Data
: World J Gastroenterol. 2009 Apr 21;15(15):1809-15. PMID:
19370776
Article Published Date
: Apr 21, 2009
Study Type
: Human Study
Additional Links
Substances
:
Olive Oil : CK(79) : AC(14)
Diseases
:
Fatty Liver : CK(493) : AC(122)
,
Insulin Resistance : CK(1034) : AC(221)
Therapeutic Actions
:
Dietary Modification: Mediterranean Diet : CK(500) : AC(58)
Pharmacological Actions
:
Antioxidants : CK(3653) : AC(1318)
,
Glucagon Like peptide 1 (GLP-1) Up-regulation : CK(118) : AC(30)
,
Glucose transporter-2 (GLUT2) expression up-regulation : CK(10) : AC(1)
,
Insulin Sensitizers : CK(167) : AC(36)
,
Interleukin-6 Downregulation : CK(470) : AC(135)
,
NF-kappaB Inhibitor : CK(595) : AC(401)
Perioperative probiotic treatment prevents postoperative infectious complications in biliary cancer surgery.
Click here to read the entire abstract
Pubmed Data
: Ann Surg. 2006 Nov;244(5):706-14. PMID:
17060763
Article Published Date
: Nov 01, 2006
Study Type
: Human Study
Additional Links
Substances
:
Lactobacillus casei : CK(151) : AC(26)
,
Lactobacillus probiotics : CK(1217) : AC(142)
,
Probiotics : CK(2468) : AC(245)
Diseases
:
Biliary Obstruction : CK(140) : AC(5)
,
Biliary Tract Diseases : CK(22) : AC(3)
,
Liver Cancer : CK(1641) : AC(266)
Pharmacological Actions
:
Interleukin-6 Downregulation : CK(470) : AC(135)
Recurrent aphthous stomatitis outbreaks are associated with low immune function.
Click here to read the entire abstract
Pubmed Data
: Georgian Med News. 2007 Oct(151):37-9. PMID:
18071210
Article Published Date
: Oct 01, 2007
Study Type
: Human Study
Additional Links
Diseases
:
Aphthous Ulcer : CK(131) : AC(14)
,
Immune Disorders: Low Immune Function : CK(488) : AC(115)
Pharmacological Actions
:
Interleukin-6 Downregulation : CK(470) : AC(135)
Additional Keywords
:
Diseases that are Linked : CK(2122) : AC(270)
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