Malondialdehyde Down-regulation

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View the Evidence: Pharmacological Actions

Cynanchum auriculatum in combination with vitamin E exhibits anti-aging properties.

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2007 Dec;32(23):2511-4. PMID: 18330246
Article Published Date : Dec 01, 2007
Study Type : Meta Analysis
Additional Links
Substances : Cynanchum Auriculatum : CK(20) : AC(1), Vitamin E : CK(1285) : AC(221)
Diseases : Aging : CK(1351) : AC(369)
Pharmacological Actions : Malondialdehyde Down-regulation : CK(76) : AC(21), Superoxide Dismutase Up-regulation : CK(131) : AC(42), Telomerase Upregulation : CK(81) : AC(25)

A fruit-enriched hypocaloric diet appears to be more effective against oxidative stress and lowering LDL cholesterol than a fruit free one.

Pubmed Data : Nutrition. 2006 Jun;22(6):593-9. PMID: 16704952
Article Published Date : Jun 01, 2006
Study Type : Human Study
Additional Links
Substances : Fruit: All : CK(1836) : AC(472)
Diseases : Cholesterol: LDL/HDL ratio : CK(432) : AC(58), Lipid Peroxidation : CK(403) : AC(127), Obesity : CK(1849) : AC(275)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Malondialdehyde Down-regulation : CK(76) : AC(21)

Resveratrol inhibits the formation of membrane protein carbonyls and lipid peroxidation in erythrocytes subjected to oxidative stress.

Pubmed Data : Appl Physiol Nutr Metab. 2009 Dec;34(6):1093-7. PMID: 20029519
Article Published Date : Dec 01, 2009
Study Type : Human Study
Additional Links
Substances : Resveratrol : CK(977) : AC(590), Stilbenes : CK(128) : AC(92)
Diseases : Lipid Peroxidation : CK(403) : AC(127), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Malondialdehyde Down-regulation : CK(76) : AC(21)

"Chronic nicotine toxicity is prevented by aqueous garlic extract."

Pubmed Data : Plant Foods Hum Nutr. 2005 Jun ;60(2):77-86. PMID: 16021835
Article Published Date : Jun 01, 2005
Study Type : Animal Study
Additional Links
Substances : Garlic : CK(485) : AC(160)
Diseases : Nicotine/Tobacco Toxicity : CK(152) : AC(26), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Malondialdehyde Down-regulation : CK(76) : AC(21)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)
Problem Substances : Nicotine : CK(56) : AC(8)
Adverse Pharmacological Actions : Oxidant : CK(104) : AC(37)

"Fucoidin, a neutrophil rolling inhibitor, reduces damage in a rat electrical burn injury model."

Pubmed Data : Burns. 2011 Nov ;37(7):1216-21. PMID: 21641115
Article Published Date : Oct 31, 2011
Study Type : Animal Study
Additional Links
Substances : Fucoidan : CK(152) : AC(72)
Diseases : Electric Injuries : CK(2) : AC(1), Electrical Burn Injury : CK(2) : AC(1), Inflammation: Neutrophil-Mediated : CK(2) : AC(2)
Pharmacological Actions : Malondialdehyde Down-regulation : CK(76) : AC(21), Neutrophil Activation: Down-Regulation : CK(2) : AC(1), Neutrophil Rolling Inhibitor : CK(2) : AC(1)

"Suppression by fucoidan of liver fibrogenesis via the TGF-β/Smad pathway in protecting against oxidative stress."

Pubmed Data : Biosci Biotechnol Biochem. 2011 ;75(5):833-40. Epub 2011 May 20. PMID: 21597183
Article Published Date : Dec 31, 2010
Study Type : Animal Study
Additional Links
Substances : Fucoidan : CK(152) : AC(72)
Diseases : Liver Cirrhosis : CK(216) : AC(32), Liver Fibrosis : CK(341) : AC(74), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Malondialdehyde Down-regulation : CK(76) : AC(21), Superoxide Dismutase Up-regulation : CK(131) : AC(42)

A Chinese formula Modified Simiao Decoction regulates renal urate transporters and enhancing antioxidant enzymes activities to improve renal dysfunction in hyperuricemic mice.

Pubmed Data : J Ethnopharmacol. 2012 Jun 26 ;142(1):248-52. Epub 2012 May 8. PMID: 22575704
Article Published Date : Jun 25, 2012
Study Type : Animal Study
Additional Links
Substances : Chinese Medicine: Modified Simiao Decoction : CK(2) : AC(1)
Diseases : Hyperuricemia : CK(253) : AC(32), Uric Acid Nephropathy : CK(5) : AC(3)
Pharmacological Actions : Malondialdehyde Down-regulation : CK(76) : AC(21), Renoprotective : CK(191) : AC(90), Superoxide Dismutase Up-regulation : CK(131) : AC(42)
Additional Keywords : Phytotherapy : CK(177) : AC(27)

A water extract of the roots of Asparagus racemosus has a preventive effect on chemically-induced hepatocarcinogenesis.

Pubmed Data : Phytother Res. 2008 Sep ;22(9):1175-82. PMID: 18729252
Article Published Date : Sep 01, 2008
Study Type : Animal Study
Additional Links
Substances : Asparagus : CK(8) : AC(7)
Diseases : Liver Cancer: Prevention : CK(109) : AC(21)
Pharmacological Actions : Chemopreventive : CK(1528) : AC(382), Malondialdehyde Down-regulation : CK(76) : AC(21), Tumor Suppressor Protein p53 Upregulation : CK(146) : AC(105)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Astaxanthin protects against cyclophosphamide-induced oxidative stress and DNA damage.

Pubmed Data : Chem Biol Interact. 2009 Aug 14;180(3):398-406. Epub 2009 Apr 2. PMID: 19539803
Article Published Date : Aug 14, 2009
Study Type : Animal Study
Additional Links
Substances : Astaxanthin : CK(353) : AC(117)
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide : CK(27) : AC(10), DNA damage : CK(711) : AC(293), Lipid Peroxidation : CK(403) : AC(127), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Malondialdehyde Down-regulation : CK(76) : AC(21), Superoxide Dismutase Up-regulation : CK(131) : AC(42)

Celery extract significantly protects the gastric mucosa and suppresses the basal gastric secretion in rats, possibly through its antioxidant potential.

Pubmed Data : Pharm Biol. 2010 Jul ;48(7):786-93. PMID: 20645778
Article Published Date : Jul 01, 2010
Study Type : Animal Study
Additional Links
Substances : Celery : CK(30) : AC(12)
Diseases : Acid Reflux : CK(288) : AC(42), Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions : Acid Blockers : CK(40) : AC(16), Anti-Ulcer Agents : CK(162) : AC(57), Malondialdehyde Down-regulation : CK(76) : AC(21)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Cistanche deserticola exhibits anti-aging properties in mice.

Pubmed Data : Zhong Yao Cai. 2008 Sep;31(9):1385-8. PMID: 19180965
Article Published Date : Sep 01, 2008
Study Type : Animal Study
Additional Links
Substances : Cistanche deserticola : CK(2) : AC(1)
Diseases : Aging : CK(1351) : AC(369), Aging: Brain : CK(1747) : AC(68), Learning disorders : CK(154) : AC(36), Memory Loss : CK(113) : AC(32), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Malondialdehyde Down-regulation : CK(76) : AC(21), Superoxide Dismutase Up-regulation : CK(131) : AC(42)

Dandelion has hepatoprotective effects against alcoholic liver damage.

Pubmed Data : Food Chem Toxicol. 2010 Jun;48(6):1632-7. Epub 2010 Mar 27. PMID: 20347918
Article Published Date : Jun 01, 2010
Study Type : Animal Study
Additional Links
Substances : Dandelion : CK(91) : AC(30)
Diseases : Alcohol Toxicity : CK(212) : AC(85), Chemically-Induced Liver Damage : CK(475) : AC(175), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Hepatoprotective : CK(557) : AC(272), Malondialdehyde Down-regulation : CK(76) : AC(21)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Dietary olive oil effect improves the antioxidant status and fatty acid profile in the erythrocyte of 2,4-D- exposed rats.

Pubmed Data : Lipids Health Dis. 2010 ;9:89. Epub 2010 Aug 25. PMID: 20738870
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Olive Oil : CK(79) : AC(14)
Diseases : Lipid Peroxidation : CK(403) : AC(127), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Malondialdehyde Down-regulation : CK(76) : AC(21)

Glutamine and arginine supplementation may help prevent necrotizing enterocolitis.

Pubmed Data : J Pediatr Gastroenterol Nutr. 2009 Jul;49(1):85-9. PMID: 19503000
Article Published Date : Jul 01, 2009
Study Type : Animal Study
Additional Links
Substances : Arginine : CK(970) : AC(169), Glutamine : CK(98) : AC(19)
Diseases : Necrotising enterocolitis : CK(79) : AC(12)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Malondialdehyde Down-regulation : CK(76) : AC(21), Superoxide Dismutase Up-regulation : CK(131) : AC(42)

L-arginine protects against pulmonary oxidative stress and antioxidant defenses during exhaustive exercise in rats.

Pubmed Data : Acta Pharmacol Sin. 2005 Aug;26(8):992-9. PMID: 16038634
Article Published Date : Aug 01, 2005
Study Type : Animal Study
Additional Links
Substances : Arginine : CK(970) : AC(169)
Diseases : Exercise-Induced Tissue Damage : CK(40) : AC(8), Lipid Peroxidation : CK(403) : AC(127), Lung Damage : CK(8) : AC(4), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Glutathione Upregulation : CK(144) : AC(48), Malondialdehyde Down-regulation : CK(76) : AC(21), Superoxide Dismutase Up-regulation : CK(131) : AC(42)

MSM has therapeutic value in an animal model of colitis.

Pubmed Data : Toxicol Appl Pharmacol. 2011 Jun 15 ;253(3):197-202. Epub 2011 Apr 2. PMID: 21463646
Article Published Date : Jun 15, 2011
Study Type : Animal Study
Additional Links
Substances : MSM (Methylsulfonylmethane) : CK(63) : AC(8)
Diseases : Colitis : CK(368) : AC(53)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Interleukin-1 beta downregulation : CK(177) : AC(70), Malondialdehyde Down-regulation : CK(76) : AC(21), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Protective effects of Pycnogenol on hyperglycemia-induced oxidative damage in the liver of type 2 diabetic rats.

Pubmed Data : Chem Biol Interact. 2010 Jul 30 ;186(2):219-27. Epub 2010 Apr 28. PMID: 20433812
Article Published Date : Jul 29, 2010
Study Type : Animal Study
Additional Links
Diseases : Diabetes: Liver Disease : CK(10) : AC(4), Diabetes Mellitus: Type 2 : CK(3429) : AC(341)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Hepatoprotective : CK(557) : AC(272), Malondialdehyde Down-regulation : CK(76) : AC(21)
Additional Keywords : Phytotherapy : CK(177) : AC(27)

Pycnogenol(®) has antioxidant and antigenotoxic effects on rats treated with cisplatin.

Pubmed Data : Biol Trace Elem Res. 2011 Sep ;142(3):638-50. Epub 2010 Jul 30. PMID: 20676799
Article Published Date : Aug 31, 2011
Study Type : Animal Study
Additional Links
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antioxidants : CK(3653) : AC(1318), Malondialdehyde Down-regulation : CK(76) : AC(21)
Additional Keywords : Drug: Cisplatin : CK(31) : AC(11)
Problem Substances : Cisplatin : CK(24) : AC(7)

Resveratrol exhibits anti-aging immunomodulatory properties.

Pubmed Data : Zhong Yao Cai. 2006 May;29(5):464-7. PMID: 16981461
Article Published Date : May 01, 2006
Study Type : Animal Study
Additional Links
Substances : Resveratrol : CK(977) : AC(590)
Diseases : Aging : CK(1351) : AC(369), Aging: Immunosenecence : CK(52) : AC(11)
Pharmacological Actions : Immunomodulatory: CD8+ Up-regulation : CK(2) : AC(1), Interleukin-6 Downregulation : CK(470) : AC(135), Interleukin-8 downregulation : CK(97) : AC(28), Malondialdehyde Down-regulation : CK(76) : AC(21), Superoxide Dismutase Up-regulation : CK(131) : AC(42)
Additional Keywords : Stilbenes : CK(402) : AC(242)

Resveratrol exhibits chemosensitizing and chemopreventive properties.

Pubmed Data : Chemotherapy. 2010;56(1):60-5. Epub 2010 Mar 19. PMID: 20299793
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol : CK(977) : AC(590), Stilbenes : CK(128) : AC(92)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66)
Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Chemopreventive : CK(1528) : AC(382), Chemosensitizer : CK(197) : AC(159), Malondialdehyde Down-regulation : CK(76) : AC(21), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)
Additional Keywords : Drug: Cisplatin : CK(31) : AC(11)

Resveratrol has anti-inflammatory and neuroprotective properties in experimental diabetic neuropathy.

Pubmed Data : Biochem Biophys Res Commun. 2010 Apr 2;394(2):360-5. Epub 2010 Mar 6. PMID: 20211601
Article Published Date : Apr 02, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol : CK(977) : AC(590), Stilbenes : CK(128) : AC(92)
Diseases : Diabetic Neuropathy : CK(22) : AC(7), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Cyclooxygenase 2 Inhibitors : CK(269) : AC(169), Interleukin-6 Downregulation : CK(470) : AC(135), Malondialdehyde Down-regulation : CK(76) : AC(21), Neuroprotective Agents : CK(962) : AC(480), NF-kappaB Inhibitor : CK(595) : AC(401), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

The results suggest that silica hydride exhibits potent hepatoprotective effects on CCl(4)-induced liver damage in mice, likely due to both the increase of antioxidant-defense system activity and the inhibition of lipid peroxidation.

Pubmed Data : Food Chem Toxicol. 2010 Jun ;48(6):1644-53. Epub 2010 Mar 27. PMID: 20350579
 
Article Published Date : May 31, 2010
Study Type : Animal Study
Additional Links
Substances : Silica Hydride : CK(2) : AC(1)
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Lipid Peroxidation : CK(403) : AC(127)
Pharmacological Actions : Malondialdehyde Down-regulation : CK(76) : AC(21)

Tocotrienol-rich fraction and tocopherol prevent aspirin-induced gastric lesions.

Pubmed Data : Asia Pac J Clin Nutr. 2002;11(4):309-13. PMID: 12495264
Article Published Date : Jan 01, 2002
Study Type : Animal Study
Additional Links
Substances : Tocotrienols : CK(22) : AC(16), Vitamin E : CK(1285) : AC(221)
Diseases : Aspirin-Induced Toxicity : CK(83) : AC(24), Gastric Ulcer : CK(246) : AC(91), Lipid Peroxidation : CK(403) : AC(127)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Gastroprotective : CK(62) : AC(31), Malondialdehyde Down-regulation : CK(76) : AC(21)

Vitamin E protects against oxidative and neurological damage caused by formaldehyde.

Pubmed Data : J Chem Neuroanat. 2005 May ;29(3):173-8. PMID: 15820619
Article Published Date : May 01, 2005
Study Type : Animal Study
Additional Links
Substances : Vitamin E : CK(1285) : AC(221)
Diseases : Brain Damage : CK(89) : AC(41), Formaldehyde Toxicity : CK(4) : AC(2), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Malondialdehyde Down-regulation : CK(76) : AC(21), Neuroprotective Agents : CK(962) : AC(480), Superoxide Dismutase Up-regulation : CK(131) : AC(42)
Problem Substances : Formaldehyde : CK(19) : AC(10)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179), Oxidant : CK(104) : AC(37)

L-arginine administration may be beneficial to patients with myocardial ischemic disorders.

Pubmed Data : Indian J Biochem Biophys. 2009 Dec;46(6):498-502. PMID: 20361713
Article Published Date : Dec 01, 2009
Study Type : Review
Additional Links
Substances : Arginine : CK(970) : AC(169)
Diseases : Myocardial Ischemia : CK(87) : AC(37)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Malondialdehyde Down-regulation : CK(76) : AC(21), Superoxide Dismutase Up-regulation : CK(131) : AC(42)

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