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Matrix metalloproteinase-2 (MMP-2) inhibitor

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Article Count - 71
Cumulative Knowledge - 155

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View the Evidence: Pharmacological Actions

EGCG has a protective effect against matrix metallopreinase in recessive dystrophic epidermolysis bullosa patients.

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Pubmed Data : J Invest Dermatol. 2007 Apr;127(4):821-8. Epub 2006 Nov 30. PMID: 17139264

Article Published Date : Apr 01, 2007

Study Type : Human Study

Additional Links

Substances : Catechin : CK(403) : AC(130)

Diseases : Epidermolysis Bullosa : CK(40) : AC(4)

Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71)

Genistein may block metastasis and mortality in prostate cancer through blocking the activation of MEK4 and MMP-2 expression.

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Pubmed Data : J Natl Cancer Inst. 2009 Aug 19;101(16):1141-55. Epub 2009 Jul 28. PMID: 19638505

Article Published Date : Aug 19, 2009

Study Type : Human Study

Additional Links

Substances : Genistein : CK(450) : AC(174)

Diseases : Prostate Cancer : CK(998) : AC(288)

Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71), Mitogen-activated protein kinase kinase 4 (MEK4) : CK(11) : AC(2)

Omega-3 fatty acids cause a reduction in the mRNA levels for various proteins known to be important in the pathology of osteoarthritis.

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Pubmed Data : Osteoarthritis Cartilage. 2009 Jul;17(7):896-905. Epub 2009 Jan 13. PMID: 19217322

Article Published Date : Jul 01, 2009

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid) : CK(582) : AC(100), Eicosapentaenoic acid (EPA) : CK(634) : AC(85), Omega-3 Fatty Acids : CK(3333) : AC(319)

Diseases : Osteoarthritis : CK(615) : AC(91)

Pharmacological Actions : Cyclooxygenase 2 Inhibitors : CK(269) : AC(169), Interleukin-1 alpha downregulation : CK(34) : AC(12), Interleukin-1 beta downregulation : CK(177) : AC(70), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Red ginseng root extract mixed with Torilus fructus and Corni fructus improves facial wrinkles and increases type I procollagen synthesis in human skin.

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Pubmed Data : J Med Food. 2009 Dec;12(6):1252-9. PMID: 20041778

Article Published Date : Dec 01, 2009

Study Type : Human Study

Additional Links

Substances : Corni Fructus : CK(10) : AC(1), Ginseng : CK(339) : AC(113), Torilus Fructus : CK(10) : AC(1), Unspecified Species : CK(11) : AC(2)

Diseases : Aging Skin : CK(360) : AC(86)

Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

The hypotensive and anti-inflammatory effect of soy nut consumption may be due to a reduction in solube vascular cell adhesion molecule-1 which results in an improvement in endothelial function.

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Pubmed Data : Am J Cardiol. 2008 Jul 1;102(1):84-6. Epub 2008 Apr 16. PMID: 18572041

Article Published Date : Jul 01, 2008

Study Type : Human Study

Additional Links

Substances : Isoflavones : CK(627) : AC(124), Soy Protein : CK(2307) : AC(56)

Diseases : C-Reactive Protein : CK(819) : AC(74), Hypertension : CK(2783) : AC(271), Inflammation : CK(1077) : AC(363)

Pharmacological Actions : Interleukin-6 Downregulation : CK(470) : AC(135), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71), Vascular Cell Adhesion Molecule-1 Inhibitor : CK(94) : AC(24)

The addition of broccoli and watercress in the diet may reduce risk of breast cancer

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Pubmed Data : Toxicol Appl Pharmacol. 2005 Dec 1 ;209(2):105-13. Epub 2005 Jun 13. PMID: 15953625

Article Published Date : Dec 01, 2005

Study Type : Human In Vitro

Additional Links

Substances : Broccoli : CK(449) : AC(185), Sulforaphane : CK(520) : AC(171), Watercress : CK(14) : AC(4)

Diseases : Breast Cancer : CK(2354) : AC(621)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71)

Additional Keywords : Isothiocyanates : CK(70) : AC(23), Plant Extracts : CK(3572) : AC(1216)

"Low molecular weight fucoidan prevents intimal hyperplasia in rat injured thoracic aorta through the modulation of matrix metalloproteinase-2 expression."

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Pubmed Data : Biochem Pharmacol. 2011 Jan 15 ;81(2):233-43. Epub 2010 Sep 29. PMID: 20887714

Article Published Date : Jan 14, 2011

Study Type : Animal Study

Additional Links

Substances : Fucoidan : CK(152) : AC(72)

Diseases : Aortic Plaques : CK(102) : AC(9), Intima Media Thickening : CK(1878) : AC(41)

Pharmacological Actions : Cardioprotective : CK(702) : AC(196), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71)

A Chinese herbal formula containing Red Sage, Cordyceps and Peach kernel is superior to methylprednisone against experimental pulmonary fibrosis.

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Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2007 May;32(9):835-9. PMID: 17639988

Article Published Date : May 01, 2007

Study Type : Animal Study

Additional Links

Substances : Red Sage : CK(134) : AC(37)

Diseases : Chemotherapy-Induced Toxicity: Bleomycin : CK(52) : AC(21)

Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71)

Additional Keywords : Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

A combination of Omega-3 fatty acids and vitamin E ameliorates or prevents vascular reactivity alterations in diabetes.

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Pubmed Data : Can J Physiol Pharmacol. 2009 Dec;87(12):1063-73. PMID: 20029543

Article Published Date : Dec 01, 2009

Study Type : Animal Study

Additional Links

Substances : Omega-3 Fatty Acids : CK(3333) : AC(319), Vitamin E : CK(1285) : AC(221)

Diseases : Diabetes: Cardiovascular Illness : CK(666) : AC(104)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Cardioprotective : CK(702) : AC(196), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71)

A red yeast rice extract inhibits the proliferation of colorectal cancer cells.

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Pubmed Data : J Med Food. 2008 Mar;11(1):91-8. PMID: 20356949

Article Published Date : Mar 01, 2008

Study Type : Animal Study

Additional Links

Substances : Red Yeast Rice : CK(164) : AC(25)

Diseases : Cancer Metastasis : CK(272) : AC(135), Colorectal Cancer : CK(877) : AC(321)

Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Apigenin protects against ovalbumin-induced asthma.

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Pubmed Data : Int Immunopharmacol. 2009 Jul;9(7-8):918-24. Epub 2009 Apr 5. PMID: 19345747

Article Published Date : Jul 01, 2009

Study Type : Animal Study

Additional Links

Substances : Apigenin : CK(76) : AC(51)

Diseases : Asthma : CK(918) : AC(134)

Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71)

Avocado/soybean unsaponifiables have a protective effect against experimental dog osteoarthritis.

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Pubmed Data : Arthritis Res Ther. 2009;11(2):R41. Epub 2009 Mar 16. PMID: 19291317

Article Published Date : Jan 01, 2009

Study Type : Animal Study

Additional Links

Substances : Avocado : CK(47) : AC(17), Soy : CK(1672) : AC(347), Unsaponifiables : CK(25) : AC(6), Vitamin E : CK(1285) : AC(221)

Diseases : Osteoarthritis : CK(615) : AC(91)

Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71), Nitric Oxide Inhibitor : CK(108) : AC(57)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Berberine attenuates experimental autoimmune encephalomyelitis in mice.

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Pubmed Data : PLoS One. 2010;5(10):e13489. Epub 2010 Oct 19. PMID: 20976070

Article Published Date : Jan 01, 2010

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Blood-Brain-Barrier Disorders : CK(25) : AC(15), Brain Inflammation : CK(79) : AC(35), Multiple Sclerosis : CK(716) : AC(133)

Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(49) : AC(30)

Blueberry inhibits the growth and metastatic potential of triple negative breast cancer in vitro and in vivo.

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Pubmed Data : Cancer Res. 2010 May 1;70(9):3594-605. Epub 2010 Apr 13. PMID: 20388778

Article Published Date : May 01, 2010

Study Type : Animal Study

Additional Links

Substances : Blueberry : CK(140) : AC(39), Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)

Diseases : Breast Cancer : CK(2354) : AC(621), Breast Cancer: Metastatic : CK(82) : AC(33), Breast Cancer: Triple Negative : CK(61) : AC(13)

Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Camptothecin encapsulated with N-trimethyl chitosan exhibits anti-cancer properties in a preclinical mouse model of liver cancer.

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Pubmed Data : Cancer Lett. 2010 Nov 1 ;297(1):56-64. Epub 2010 May 23. PMID: 20546992

Article Published Date : Nov 01, 2010

Study Type : Animal Study

Additional Links

Substances : Camptothecin : CK(7) : AC(6)

Diseases : Liver Cancer : CK(1641) : AC(266)

Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Chemopreventive : CK(1528) : AC(382), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71)

Curcumin improves left ventricular function in pressure overloaded rabbits.

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Pubmed Data : Biol Pharm Bull. 2004 Feb;27(2):198-202. PMID: 14758033

Article Published Date : Feb 01, 2004

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Left Ventricular Dysfunction : CK(65) : AC(9), Left Ventricular Hypertrophy : CK(44) : AC(5)

Pharmacological Actions : Cardiovascular Agents : CK(50) : AC(10), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Curcumin inhibits prostate cancer tumors.

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Pubmed Data : Peptides. 2009 Dec;30(12):2357-64. Epub 2009 Sep 20. PMID: 19772879

Article Published Date : Dec 01, 2009

Study Type : Transgenic Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Prostate Cancer : CK(998) : AC(288)

Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1052) : AC(775), Cyclooxygenase 2 Inhibitors : CK(269) : AC(169), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71)

Curcumin inhibits the growth of choroidal melanoma.

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Pubmed Data : Cancer Biol Ther. 2011 Jan 15;11(2):229-35. Epub 2011 Jan 15. PMID: 21084858

Article Published Date : Jan 15, 2011

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Melanoma : CK(171) : AC(87), Melanoma: Choroidal : CK(2) : AC(1)

Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(49) : AC(30)

Curcumin inhibits tumor growth and angiogenesis in glioblastoma xenografts.

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Pubmed Data : Mol Nutr Food Res. 2010 Aug;54(8):1192-201. PMID: 20087857

Article Published Date : Aug 01, 2010

Study Type : Transgenic Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Glioblastoma : CK(46) : AC(20)

Pharmacological Actions : Anti-Angiogenic : CK(143) : AC(101), Anticarcinogenic Agents : CK(521) : AC(275), Antiproliferative : CK(1052) : AC(775), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71)

Curcumin may have a beneficial effect in degenerative aortic aneurysms.

Click here to read the entire abstract

Pubmed Data : Ann Vasc Surg. 2006 May;20(3):360-8. Epub 2006 May 19. PMID: 16779518

Article Published Date : May 01, 2006

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Aortic Aneurysm : CK(52) : AC(6)

Pharmacological Actions : Interleukin-6 Downregulation : CK(470) : AC(135), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71), NF-kappaB Inhibitor : CK(595) : AC(401)

Curcumin prevents human aortic smooth muscle cells migration associated with the development atherosclerosis.

Click here to read the entire abstract

Pubmed Data : Nutr Metab Cardiovasc Dis. 2010 Feb;20(2):125-32. Epub 2009 May 17. PMID: 19447587

Article Published Date : Feb 01, 2010

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Atherosclerosis : CK(523) : AC(77)

Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Antioxidants : CK(3653) : AC(1318), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Curcumin protects against alcohol and oxidized fat-induced liver toxicity.

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Pubmed Data : Ital J Biochem. 2004 Jul;53(2):61-6. PMID: 15646009

Article Published Date : Jul 01, 2004

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Alcohol Toxicity : CK(212) : AC(85), Chemically-Induced Liver Damage : CK(475) : AC(175)

Pharmacological Actions : Hepatoprotective : CK(557) : AC(272), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71)

Curcumin works synergistically with paclitaxel to inhibit breast cancer cell metastasis to the lung in a mouse model.

Click here to read the entire abstract

Pubmed Data : Clin Cancer Res. 2005 Oct 15;11(20):7490-8. PMID: 16243823

Article Published Date : Oct 15, 2005

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Breast Cancer : CK(2354) : AC(621), Breast Cancer: Lung Metastasis : CK(13) : AC(7), Lung Cancer : CK(496) : AC(198)

Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Apoptotic : CK(1489) : AC(1114), Cyclooxygenase 2 Inhibitors : CK(269) : AC(169), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71), NF-kappaB Inhibitor : CK(595) : AC(401)

Additional Keywords : Drug: Paclitaxel : CK(36) : AC(13), Drug-Plant-Vitamin Synergies : CK(1011) : AC(268)

Curcumin's antiulcer activity is primarily attributed to MMP-9 inhibition, one of the major path-ways of ulcer healing.

Click here to read the entire abstract

Pubmed Data : J Biol Chem. 2005 Mar 11;280(10):9409-15. Epub 2004 Dec 22. PMID: 15615723

Article Published Date : Mar 11, 2005

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Gastric Ulcer : CK(246) : AC(91), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57), Gastroprotective : CK(62) : AC(31), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(49) : AC(30)

Additional Keywords : Drug: Indomethacin : CK(30) : AC(17)

Dietary red palm oil supplementation reduces myocardial infarct size in an isolated perfused rat heart model.

Click here to read the entire abstract

Pubmed Data : J Clin Endocrinol Metab. 2002 Mar;87(3):1010-4. PMID: 20565865

Article Published Date : Mar 01, 2002

Study Type : Animal Study

Additional Links

Substances : Palm Oil : CK(30) : AC(16)

Diseases : Myocardial Infarction : CK(2632) : AC(117)

Pharmacological Actions : Cardioprotective : CK(702) : AC(196), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71)

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Two recent studies have found that a constituent of olives and olive oil inhibits the growth of breast cancer and the development of Alzheimer's disease.

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