NF-kappaB Inhibitor

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View the Evidence: Pharmacological Actions

Astaxanthin prevents in vitro auto-oxidative injury in human lymphocytes.

Pubmed Data : Cell Biol Toxicol. 2010 Oct;26(5):457-67. Epub 2010 Mar 14. PMID: 20229275
Article Published Date : Oct 01, 2010
Study Type : Human Study
Additional Links
Substances : Astaxanthin : CK(353) : AC(117)
Diseases : Immune Disorders: Low Immune Function : CK(488) : AC(115), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Apoptotic : CK(1489) : AC(1114), NF-kappaB Inhibitor : CK(595) : AC(401), Superoxide Dismutase Up-regulation : CK(131) : AC(42)

Bilberry has anti-inflammatory properties.

Pubmed Data : Eur J Nutr. 2010 Sep;49(6):345-55. Epub 2010 Feb 2. PMID: 20119859
Article Published Date : Sep 01, 2010
Study Type : Human Study
Additional Links
Substances : Bilberry : CK(39) : AC(11), Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)
Diseases : Inflammation : CK(1077) : AC(363), Lipopolysaccharide-Induced Toxicity : CK(227) : AC(128)
Pharmacological Actions : NF-kappaB Inhibitor : CK(595) : AC(401)

Cashew may have anti-inflammatory activity in rheumatoid arthritis patients.

Pubmed Data : J Ethnopharmacol. 2006 Dec 6;108(3):398-406. Epub 2006 Jun 2. PMID: 16824715
Article Published Date : Dec 06, 2006
Study Type : Human Study
Additional Links
Diseases : Lipopolysaccharide-Induced Toxicity : CK(227) : AC(128), Rheumatoid Arthritis : CK(424) : AC(64)
Pharmacological Actions : Interleukin-1 beta downregulation : CK(177) : AC(70), Interleukin-6 Downregulation : CK(470) : AC(135), NF-kappaB Inhibitor : CK(595) : AC(401)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Curcumin selectively induces programmed cell death in cutaneous T-cell lymphoma cell lines and in peripheral blood mononuclear cells (PBMCs).

Pubmed Data : J Invest Dermatol. 2010 Aug;130(8):2110-9. Epub 2010 Apr 15. PMID: 20393484
Article Published Date : Aug 01, 2010
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : T-Cell Lymphoma: Cutaneous : CK(10) : AC(1)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), NF-kappaB Inhibitor : CK(595) : AC(401)

French maritime pine bark extract (Pycnogenol) displays anti-inflammatory effects in vivo.

Pubmed Data : J Inflamm (Lond). 2006;3:1. Epub 2006 Jan 27. PMID: 16441890
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Substances : Pycnogenol (Pine Bark) : CK(385) : AC(61)
Diseases : Inflammation : CK(1077) : AC(363)
Pharmacological Actions : Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(49) : AC(30), NF-kappaB Inhibitor : CK(595) : AC(401)

Olive oil consumption has an ameliorative effect in non-alcoholic fatty liver disease.

Pubmed Data : World J Gastroenterol. 2009 Apr 21;15(15):1809-15. PMID: 19370776
Article Published Date : Apr 21, 2009
Study Type : Human Study
Additional Links
Substances : Olive Oil : CK(79) : AC(14)
Diseases : Fatty Liver : CK(493) : AC(122), Insulin Resistance : CK(1034) : AC(221)
Therapeutic Actions : Dietary Modification: Mediterranean Diet : CK(500) : AC(58)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Glucagon Like peptide 1 (GLP-1) Up-regulation : CK(118) : AC(30), Glucose transporter-2 (GLUT2) expression up-regulation : CK(10) : AC(1), Insulin Sensitizers : CK(167) : AC(36), Interleukin-6 Downregulation : CK(470) : AC(135), NF-kappaB Inhibitor : CK(595) : AC(401)

Zyflamend (a multi-herbal formula) has significant therapeutic activity in treating high-grade prostatic intraepithelial neoplasia.

Pubmed Data : J Soc Integr Oncol. 2009 Spring;7(2):43-51. PMID: 19476738
Article Published Date : Mar 01, 2009
Study Type : Human Study
Additional Links
Substances : Zyflamend : CK(20) : AC(7)
Diseases : Elevated CRP : CK(72) : AC(8), Prostate: PSA Doubling : CK(133) : AC(16), Prostatic intraepithelial neoplasia (PIN) : CK(20) : AC(2)
Pharmacological Actions : NF-kappaB Inhibitor : CK(595) : AC(401)

"Ginger extract (Zingiber officinale) has anti-cancer and anti-inflammatory effects on ethionine-induced hepatoma rats."

Pubmed Data : Clinics (Sao Paulo). 2008 Dec ;63(6):807-13. PMID: 19061005
Article Published Date : Dec 01, 2008
Study Type : Animal Study
Additional Links
Substances : Ginger : CK(310) : AC(89)
Diseases : Liver Cancer: Prevention : CK(109) : AC(21)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Antineoplastic Agents : CK(877) : AC(496), NF-kappaB Inhibitor : CK(595) : AC(401), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

"Tanshinone IIA prevents uric acid nephropathy in rats through NF-κB inhibition."

Pubmed Data : Planta Med. 2012 Jun ;78(9):866-73. Epub 2012 May 15. PMID: 22588836
Article Published Date : May 31, 2012
Study Type : Animal Study
Additional Links
Substances : Tanshinone IIA : CK(2) : AC(1)
Diseases : Hyperuricemia : CK(253) : AC(32), Uric Acid Nephropathy : CK(5) : AC(3)
Pharmacological Actions : NF-kappaB Inhibitor : CK(595) : AC(401)
Additional Keywords : Drug: Allopurinol : CK(6) : AC(3), Natural Substances Versus Drugs : CK(988) : AC(165)
Problem Substances : Allopurinol : CK(37) : AC(5)

A curcumin complex reduces acute lung injury severity.

Pubmed Data : Am J Respir Cell Mol Biol. 2012 Feb 3. Epub 2012 Feb 3. PMID: 22312018
Article Published Date : Feb 03, 2012
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Lung Injury: Acute : CK(32) : AC(11)
Pharmacological Actions : NF-kappaB Inhibitor : CK(595) : AC(401)

Açaí juice attenuates atherosclerosis in ApoE deficient mice through antioxidant and anti-inflammatory activities.

Pubmed Data : Atherosclerosis. 2011 Jun;216(2):327-33. Epub 2011 Feb 24. PMID: 21411096
Article Published Date : Jun 01, 2011
Study Type : Animal Study
Additional Links
Substances : Acai : CK(27) : AC(7)
Diseases : Atherosclerosis : CK(523) : AC(77)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Antioxidants : CK(3653) : AC(1318), NF-kappaB Inhibitor : CK(595) : AC(401)

Allylmethylsulfide (AMS), a volatile organosulfur derivative from garlic has radioprotective properties.

Pubmed Data : J Med Food. 2009 Jun;12(3):542-51. PMID: 19627202
Article Published Date : Jun 01, 2009
Study Type : Animal Study
Additional Links
Substances : Garlic : CK(485) : AC(160)
Diseases : Lipid Peroxidation : CK(403) : AC(127), Radiation Induced Illness : CK(1018) : AC(249)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Cyclooxygenase 2 Inhibitors : CK(269) : AC(169), NF-kappaB Inhibitor : CK(595) : AC(401), Radioprotective : CK(456) : AC(183), Vascular Cell Adhesion Molecule-1 Inhibitor : CK(94) : AC(24)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Alpha lipoic acid attenuates cisplatin-induced acute kidney injury in mice by suppressing renal inflammation.

Pubmed Data : Nephrol Dial Transplant. 2009 Oct;24(10):3012-20. Epub 2009 May 27. PMID: 19474282
Article Published Date : Oct 01, 2009
Study Type : Animal Study
Additional Links
Substances : Alpha-Lipoic Acid : CK(384) : AC(82)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66)
Pharmacological Actions : NF-kappaB Inhibitor : CK(595) : AC(401)

Apigenin enhances the anti-tumor effect of gemcitabine.

Pubmed Data : Cancer Lett. 2008 Jan 18;259(1):39-49. Epub 2007 Oct 29. PMID: 17967505
Article Published Date : Jan 18, 2008
Study Type : Animal Study
Additional Links
Substances : Apigenin : CK(76) : AC(51)
Diseases : Pancreatic Cancer : CK(530) : AC(168)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), NF-kappaB Inhibitor : CK(595) : AC(401)
Additional Keywords : Drug: Gemcitabine : CK(36) : AC(13), Drug-Plant-Vitamin Synergies : CK(1011) : AC(268)

Apigenin, a dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation in mice.

Pubmed Data : Arthritis Res Ther. 2009;11(2):R59. Epub 2009 Apr 30. PMID: 19405952
Article Published Date : Jan 01, 2009
Study Type : Animal Study
Additional Links
Substances : Apigenin : CK(76) : AC(51)
Diseases : Autoimmune Diseases : CK(5317) : AC(779), Lupus Erythematosus: Systemic : CK(949) : AC(53)
Pharmacological Actions : Cyclooxygenase 2 Inhibitors : CK(269) : AC(169), NF-kappaB Inhibitor : CK(595) : AC(401)

Arginine reverses ethanol-induced inflammatory and fibrotic changes in liver despite continued ethanol administration.

Pubmed Data : J Pharmacol Exp Ther. 2001 Dec;299(3):832-9. PMID: 11714866
Article Published Date : Dec 01, 2001
Study Type : Animal Study
Additional Links
Substances : Arginine : CK(970) : AC(169)
Diseases : Alcoholic Liver Disease : CK(146) : AC(50), Inflammation : CK(1077) : AC(363), Liver Fibrosis : CK(341) : AC(74)
Pharmacological Actions : Cyclooxygenase 2 Inhibitors : CK(269) : AC(169), NF-kappaB Inhibitor : CK(595) : AC(401), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Astaxanthin exhibits anti-inflammatory and anti-cancer activity in a rat model of colon cnacer.

Pubmed Data : Invest New Drugs. 2011 Apr;29(2):207-24. Epub 2009 Oct 30. PMID: 19876598
Article Published Date : Apr 01, 2011
Study Type : Animal Study
Additional Links
Substances : Astaxanthin : CK(353) : AC(117)
Diseases : Cancer Metastasis : CK(272) : AC(135), Colon Cancer : CK(895) : AC(233), Colorectal Cancer : CK(877) : AC(321), Inflammation : CK(1077) : AC(363)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Chemopreventive : CK(1528) : AC(382), Cyclooxygenase 2 Inhibitors : CK(269) : AC(169), NF-kappaB Inhibitor : CK(595) : AC(401)

Baicalein, a compound found within Chinese skullcap, protects gainst endotoxic shock in rats in vivo and in vitro.

Pubmed Data : Biochem Pharmacol. 2007 Mar 15;73(6):793-804. Epub 2006 Dec 2. PMID: 17182007
Article Published Date : Mar 15, 2007
Study Type : Animal Study
Additional Links
Substances : Chinese Skullcap : CK(97) : AC(57)
Diseases : Endotoxemia : CK(187) : AC(40), Shock: Toxic : CK(6) : AC(2)
Pharmacological Actions : NF-kappaB Inhibitor : CK(595) : AC(401), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Baicalin inhibits age-associated NF-kappaB activiation.

Pubmed Data : Mech Ageing Dev. 2006 Sep;127(9):719-25. Epub 2006 Jun 12. PMID: 16766019
Article Published Date : Sep 01, 2006
Study Type : Animal Study
Additional Links
Substances : Chinese Skullcap : CK(97) : AC(57)
Diseases : Aging : CK(1351) : AC(369)
Pharmacological Actions : NF-kappaB Inhibitor : CK(595) : AC(401)

Bee venom prevents cholecystokinin-induced acute pancreatitis in rats.

Pubmed Data : Pancreas. 2008 Mar;36(2):e22-9. PMID: 18376296
Article Published Date : Mar 01, 2008
Study Type : Animal Study
Additional Links
Substances : Bee Venom : CK(20) : AC(8)
Diseases : Pancreatitis : CK(164) : AC(40)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Heat Shock Protein Inducer : CK(51) : AC(17), Interleukin-1 alpha downregulation : CK(34) : AC(12), Interleukin-6 Downregulation : CK(470) : AC(135), NF-kappaB Inhibitor : CK(595) : AC(401), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Both curcumin and resveratrol show promise as anti-cachexia agents, whereas resveratrol performed better in this study.

Pubmed Data : Br J Cancer. 2004 Nov 1;91(9):1742-50. PMID: 15477867
Article Published Date : Nov 01, 2004
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482), Resveratrol : CK(977) : AC(590)
Diseases : Cachexia : CK(40) : AC(8), Muscle Atrophy : CK(56) : AC(22)
Pharmacological Actions : Enzyme Inhibitors : CK(372) : AC(208), NF-kappaB Inhibitor : CK(595) : AC(401), Proteasome Inhibitors : CK(41) : AC(27)
Additional Keywords : Stilbenes : CK(402) : AC(242)

Cinnamaldehyde suppresses age-related inflammatory NF-kappaB activation.

Pubmed Data : Biogerontology. 2007 Oct;8(5):545-54. Epub 2007 May 8. PMID: 17486422
Article Published Date : Oct 01, 2007
Study Type : Animal Study
Additional Links
Substances : Cinnamaldehyde : CK(170) : AC(17), Cinnamon : CK(135) : AC(61)
Diseases : Aging : CK(1351) : AC(369)
Pharmacological Actions : NF-kappaB Inhibitor : CK(595) : AC(401)

Cocoa polyphenols may inhibit tumor promotion through antioxidant and antiinflammatory mechanisms.

Pubmed Data : J Nutr. 2006 May;136(5):1150-5. PMID: 16614396
Article Published Date : May 01, 2006
Study Type : Animal Study
Additional Links
Substances : Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)
Diseases : Tumors : CK(197) : AC(110)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Antioxidants : CK(3653) : AC(1318), Cyclooxygenase 2 Inhibitors : CK(269) : AC(169), NF-kappaB Inhibitor : CK(595) : AC(401)

Cordyceps suppresses the expression of diabetes regulating genes by inhibiting lipopolysaccharide-induced inflammation in macrophages.

Pubmed Data : Immune Netw. 2009 Jun;9(3):98-105. Epub 2009 Jun 30. PMID: 20107539
Article Published Date : Jun 01, 2009
Study Type : Animal Study
Additional Links
Substances : Cordyceps sinensis : CK(90) : AC(32)
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Lipopolysaccharide-Induced Toxicity : CK(227) : AC(128)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), NF-kappaB Inhibitor : CK(595) : AC(401)

Crocetin protects against cardiac hypertrophy.

Pubmed Data : J Cell Mol Med. 2009 May;13(5):909-25. Epub 2008 Dec 24. PMID: 19413885
Article Published Date : May 01, 2009
Study Type : Animal Study
Additional Links
Substances : Crocetin : CK(5) : AC(3)
Diseases : Cardiac Hypertrophy : CK(54) : AC(22), Cardiomegaly : CK(13) : AC(7)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Cardioprotective : CK(702) : AC(196), NF-kappaB Inhibitor : CK(595) : AC(401)

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