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Nitric Oxide Enhancer

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Article Count - 37
Cumulative Knowledge - 151

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Quick Summary: Current access displays 2 out of 23 associated Substances

Name	Cumulative Knowledge	Article Count	Focus Articles
Arginine	71	16	Log in \| Sign up
Citrulline	12	2	Log in \| Sign up

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View the Evidence: Pharmacological Actions

L-arginine therapy has a beneficial effect in fetal growth retardation due to pregnancy-induced hypertension

Click here to read the entire abstract

Pubmed Data : Nan Fang Yi Ke Da Xue Xue Bao. 2007 Feb;27(2):198-200. PMID: 17355936

Article Published Date : Feb 01, 2007

Study Type : Human Study

Additional Links

Substances : Arginine : CK(970) : AC(169)

Diseases : Fetal Growth Retardation : CK(20) : AC(2), Hypertension: Pre-Eclampsia Induced : CK(142) : AC(15)

Pharmacological Actions : Nitric Oxide Enhancer : CK(149) : AC(37)

Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutr J. 2012 Sep 26 ;11(1):79. Epub 2012 Sep 26. PMID: 23013352

Article Published Date : Sep 25, 2012

Study Type : Human Study

Additional Links

Substances : Curcumin: Lipidated : CK(10) : AC(1)

Diseases : ALT: Elevated : CK(60) : AC(10), Oxidative Stress : CK(1945) : AC(710), Plasma beta amyloid protein concentrations: elevated : CK(10) : AC(1), Plasma catalase activities: elevated : CK(10) : AC(1), Salivary amylase levels: elevated : CK(10) : AC(1), Soluble cell adhesion molecules (sCAMs): elevated : CK(10) : AC(1), Triglycerides: Elevated : CK(340) : AC(65)

Pharmacological Actions : Nitric Oxide Enhancer : CK(149) : AC(37)

Glycine propionyl-L-carnitine (GPLC) supplementation combined with eight weeks of aerobic exercise decreases lipid peroxidation and elevates nitric oxide.

Click here to read the entire abstract

Pubmed Data : Int J Vitam Nutr Res. 2009 May ;79(3):131-41. PMID: 20209464

Article Published Date : May 01, 2009

Study Type : Human Study

Additional Links

Substances : Carnitine : CK(672) : AC(69)

Diseases : Lipid Peroxidation : CK(403) : AC(127)

Pharmacological Actions : Nitric Oxide Enhancer : CK(149) : AC(37)

L-arginine in combination with Pycnogenol causes a significant improvement in sexual function in men with erectile dysfunction without any side effects.

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Pubmed Data : J Sex Marital Ther. 2003 May-Jun;29(3):207-13. PMID: 12851125

Article Published Date : May 01, 2003

Study Type : Human Study

Additional Links

Substances : Arginine : CK(970) : AC(169), Flavonoids : CK(909) : AC(289)

Diseases : Erectile Dysfunction : CK(510) : AC(41)

Pharmacological Actions : Nitric Oxide Enhancer : CK(149) : AC(37), Platelet Aggregation Inhibitors : CK(173) : AC(37)

L-Arginine supplementation enhances diabetic wound healing.

Click here to read the entire abstract

Pubmed Data : Metabolism. 2002 Oct;51(10):1269-73. PMID: 12370845

Article Published Date : Oct 01, 2002

Study Type : Human Study

Additional Links

Substances : Arginine : CK(970) : AC(169)

Diseases : Diabetic Ulcer : CK(122) : AC(19), Wound Healing : CK(235) : AC(72)

Pharmacological Actions : Nitric Oxide Enhancer : CK(149) : AC(37)

L-Arginine treatment has therapeutic value in asymmetric fetal growth restriction.

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Pubmed Data : Int J Gynaecol Obstet. 2005 Jan;88(1):15-8. PMID: 15617699

Article Published Date : Jan 01, 2005

Study Type : Human Study

Additional Links

Substances : Arginine : CK(970) : AC(169)

Diseases : Fetal Growth Retardation : CK(20) : AC(2)

Pharmacological Actions : Nitric Oxide Enhancer : CK(149) : AC(37)

L-Arginine, the substrate for NO synthesis, may be an alternative treatment for premature atherosclerosis.

Click here to read the entire abstract

Pubmed Data : Int J Cardiol. 2007 Apr 4;116(3):300-8. Epub 2006 Jul 24. PMID: 16860889

Article Published Date : Apr 04, 2007

Study Type : Human Study

Additional Links

Substances : Arginine : CK(970) : AC(169)

Diseases : Atherosclerosis : CK(523) : AC(77), Endothelial Dysfunction : CK(897) : AC(173)

Pharmacological Actions : Antihypertensive Agents : CK(196) : AC(38), Cardiovascular Agents : CK(50) : AC(10), Nitric Oxide Enhancer : CK(149) : AC(37)

Long-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease.

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Pubmed Data : Circulation. 1999 Jun 29;99(25):3234-40. PMID: 10385496

Article Published Date : Jun 29, 1999

Study Type : Human Study

Additional Links

Substances : Vitamin C : CK(1274) : AC(238)

Diseases : Coronary Artery Disease : CK(1305) : AC(136), Endothelial Dysfunction : CK(897) : AC(173)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Nitric Oxide Enhancer : CK(149) : AC(37)

Regular long-term aerobic exercise reduced migraine pain severity, frequency and duration possibly due to increased nitric oxide production.

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Pubmed Data : Am J Clin Nutr. 2008 Jul;88(1):58-63. PMID: 12971707

Article Published Date : Jul 01, 2008

Study Type : Human Study

Additional Links

Diseases : Migraine Disorders : CK(486) : AC(58)

Pharmacological Actions : Nitric Oxide Enhancer : CK(149) : AC(37)

Short-term l-citrulline supplementation may functionally improve arterial stiffness, independent of blood pressure, in humans.

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Pubmed Data : Int J Cardiol. 2010 Nov 8. Epub 2010 Nov 8. PMID: 21067832

Article Published Date : Nov 08, 2010

Study Type : Human Study

Additional Links

Substances : Citrulline : CK(82) : AC(14)

Diseases : Arterial Hardening: Elasticity : CK(128) : AC(17)

Pharmacological Actions : Nitric Oxide Enhancer : CK(149) : AC(37)

Arginine supplementation increased net protein balance in skin wound and muscle by a mechanism which was independent of nitric oxide production.

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Pubmed Data : Clin Nutr. 2008 Aug;27(4):649-56. Epub 2008 Mar 7. PMID: 18316142

Article Published Date : Aug 01, 2008

Study Type : Animal Study

Additional Links

Substances : Arginine : CK(970) : AC(169)

Diseases : Muscle Atrophy : CK(56) : AC(22), Wound Healing : CK(235) : AC(72)

Pharmacological Actions : Anabolic Agents : CK(42) : AC(10), Nitric Oxide Enhancer : CK(149) : AC(37)

"Nitrite-generated NO circumvents dysregulated arginine/NOS signaling to protect against intimal hyperplasia in Sprague-Dawley rats."

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Clin Invest. 2011 Apr ;121(4):1646-56. Epub 2011 Mar 23. PMID: 21436585

Article Published Date : Apr 01, 2011

Study Type : Animal Study

Additional Links

Substances : Arginine : CK(970) : AC(169), Nitrite : CK(2) : AC(1)

Diseases : Endothelial Dysfunction : CK(897) : AC(173)

Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Nitric Oxide Enhancer : CK(149) : AC(37)

Arginine may work synergistically with statin drugs to prevent atherosclerosis development.

Click here to read the entire abstract

Pubmed Data : Ann Biol Clin (Paris). 2005 Sep-Oct;63(5):443-55. PMID: 16230278

Article Published Date : Sep 01, 2005

Study Type : Animal Study

Additional Links

Substances : Arginine : CK(970) : AC(169)

Diseases : Atherosclerosis : CK(523) : AC(77)

Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142), Nitric Oxide Enhancer : CK(149) : AC(37)

Additional Keywords : Drug Synergy : CK(327) : AC(147)

Eicosapentaenoic acid may have a therapeutic role in attenuating pulmonary hypertension.

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2010 Jun 25;636(1-3):108-13. Epub 2010 Mar 27. PMID: 20347779

Article Published Date : Jun 25, 2010

Study Type : Animal Study

Additional Links

Substances : EPA (Eicosapentaenoic Acid) : CK(595) : AC(84)

Diseases : Endothelial Dysfunction : CK(897) : AC(173), Pulmonary Hypertension : CK(89) : AC(33)

Pharmacological Actions : Nitric Oxide Enhancer : CK(149) : AC(37)

Folic acid reverts dysfunction of endothelial nitric oxide synthase.

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Pubmed Data : Circ Res. 2000 Jun 9;86(11):1129-34. PMID: 10850963

Article Published Date : Jun 09, 2000

Study Type : Animal Study

Additional Links

Substances : 5-Methyltetrahydrofolate (MTHF) : CK(42) : AC(5), Folic Acid : CK(542) : AC(77)

Diseases : Endothelial Dysfunction : CK(897) : AC(173)

Pharmacological Actions : Nitric Oxide Enhancer : CK(149) : AC(37)

Garlic and onion attenuates vascular inflammation and oxidative stress in fructose-fed rats.

Click here to read the entire abstract

Pubmed Data : J Nutr Metab. 2011 ;2011:475216. Epub 2011 Aug 25. PMID: 21876795

Article Published Date : Jan 01, 2011

Study Type : Animal Study

Additional Links

Substances : Garlic : CK(485) : AC(160), Onion : CK(452) : AC(42)

Diseases : Endothelial Dysfunction : CK(897) : AC(173), Insulin Resistance : CK(1034) : AC(221), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Antioxidants : CK(3653) : AC(1318), Nitric Oxide Enhancer : CK(149) : AC(37), Vascular Cell Adhesion Molecule-1 Inhibitor : CK(94) : AC(24)

Problem Substances : Fructose : CK(356) : AC(103)

Adverse Pharmacological Actions : Endocrine Disruptor: Insulin Resistance : CK(152) : AC(31), Nitric Oxide Synthase (eNOS) Down-Regulation : CK(2) : AC(1), Vascular Cell Adhesion Molecule-1 (VCAM-1) Up-Regulation : CK(2) : AC(1)

Genistein attenuates low temperature induced pulmonary hypertension in broiler chicks by modulating endothelial function.

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2010 Dec 15;649(1-3):242-8. Epub 2010 Sep 18. PMID: 20854807

Article Published Date : Dec 15, 2010

Study Type : Animal Study

Additional Links

Substances : Genistein : CK(450) : AC(174)

Diseases : Pulmonary Hypertension : CK(89) : AC(33)

Pharmacological Actions : Nitric Oxide Enhancer : CK(149) : AC(37)

Ginsenoside Rg1, a compound found within ginseng, improves male copulatory behavior in mice.

Click here to read the entire abstract

Pubmed Data : J Sex Med. 2009 Sep 14. Epub 2009 Sep 14. PMID: 19751391

Article Published Date : Sep 14, 2009

Study Type : Animal Study

Additional Links

Substances : Ginsenosides : CK(48) : AC(19)

Diseases : Erectile Dysfunction : CK(510) : AC(41), Low Libido : CK(73) : AC(21), Low Testosterone : CK(385) : AC(70)

Pharmacological Actions : Aphrodisiac : CK(49) : AC(17), Nitric Oxide Enhancer : CK(149) : AC(37), Secretagogue : CK(158) : AC(36)

Gynura procumbens has antihypertensive effects in spontaneously hypertensive rats.

Click here to read the entire abstract

Pubmed Data : J Med Food. 2006;9(4):587-90. PMID: 17201650

Article Published Date : Jan 01, 2006

Study Type : Animal Study

Additional Links

Substances : Gynura Procumbens : CK(12) : AC(7)

Diseases : Hypertension : CK(2783) : AC(271)

Pharmacological Actions : Antihypertensive Agents : CK(196) : AC(38), Nitric Oxide Enhancer : CK(149) : AC(37)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

L-arginine has a beneficial effect on the nitric-oxide producing pathway in rats treated with alloxan.

Click here to read the entire abstract

Pubmed Data : J Physiol. 2007 Nov 1;584(Pt 3):921-33. Epub 2007 Aug 23. PMID: 17717015

Article Published Date : Nov 01, 2007

Study Type : Animal Study

Additional Links

Substances : Arginine : CK(970) : AC(169)

Diseases : Alloxan toxicity : CK(12) : AC(6), Diabetes Mellitus: Type 1 : CK(1107) : AC(218)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), NF-kappaB Inhibitor : CK(595) : AC(401), Nitric Oxide Enhancer : CK(149) : AC(37)

Additional Keywords : Beta Cell Regeneration : CK(60) : AC(24)

L-arginine has a cardioprotective effect in an experimental model of hypercholesterolemic rabbits aorta.

Click here to read the entire abstract

Pubmed Data : Pathophysiology. 2009 Jun;16(1):9-13. Epub 2009 Jan 24. PMID: 19168337

Article Published Date : Jun 01, 2009

Study Type : Animal Study

Additional Links

Substances : Arginine : CK(970) : AC(169)

Diseases : Aortic Stenosis : CK(44) : AC(11), Arterial Plaque : CK(439) : AC(20), Hypercholesterolemia : CK(1517) : AC(165)

Pharmacological Actions : Cardioprotective : CK(702) : AC(196), Nitric Oxide Enhancer : CK(149) : AC(37)

L-arginine has a protective effect against cisplatin-induced renal oxidative stress and toxicity.

Click here to read the entire abstract

Pubmed Data : Basic Clin Pharmacol Toxicol. 2005 Aug;97(2):91-7. PMID: 15998355

Article Published Date : Aug 01, 2005

Study Type : Animal Study

Additional Links

Substances : Arginine : CK(970) : AC(169)

Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antioxidants : CK(3653) : AC(1318), Enzyme Inhibitors : CK(372) : AC(208), Nitric Oxide Enhancer : CK(149) : AC(37)

L-arginine improve the NO production and prevents glomerular hypertrophy in the offspring of diabetic mothers.

Click here to read the entire abstract

Pubmed Data : Pediatr Res. 2007 Aug;62(2):145-50. PMID: 17597655

Article Published Date : Aug 01, 2007

Study Type : Animal Study

Additional Links

Substances : Arginine : CK(970) : AC(169)

Diseases : Endothelial Dysfunction : CK(897) : AC(173), Gestational Diabetes : CK(44) : AC(6), Hypertension : CK(2783) : AC(271), Prenatal Nutrition: Prevention of Problems : CK(357) : AC(41)

Pharmacological Actions : Nitric Oxide Enhancer : CK(149) : AC(37), Vasodilator Agents : CK(262) : AC(54)

L-arginine improves the erectile response of rats.

Click here to read the entire abstract

Pubmed Data : J Urol. 1997 Sep;158(3 Pt 1):942-7. PMID: 9258123

Article Published Date : Sep 01, 1997

Study Type : Animal Study

Additional Links

Substances : Arginine : CK(970) : AC(169)

Diseases : Erectile Dysfunction : CK(510) : AC(41)

Pharmacological Actions : Nitric Oxide Enhancer : CK(149) : AC(37)

L-arginine may have a beneficial effect on airway hyperresponsiveness and airway inflammation in asthma.

Click here to read the entire abstract

Pubmed Data : J Allergy Clin Immunol. 2010 Mar;125(3):626-35. Epub 2010 Feb 11. PMID: 20153031

Article Published Date : Mar 01, 2010

Study Type : Animal Study

Additional Links

Substances : Arginine : CK(970) : AC(169)

Diseases : Allergic Airway Diseases : CK(41) : AC(17), Asthma : CK(918) : AC(134), Bronchial Asthma : CK(984) : AC(131), Inflammation : CK(1077) : AC(363), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Nitric Oxide Enhancer : CK(149) : AC(37)

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