Nitric Oxide Inhibitor

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View the Evidence: Pharmacological Actions

Curcumin acts as an adjuvant to imatinib in decreasing the NO levels and may help in the treatment of CML patients.

Pubmed Data : J Oncol Pharm Pract. 2011 Aug 15. Epub 2011 Aug 15. PMID: 21844132
Article Published Date : Aug 15, 2011
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(2923) : AC(1482), Turmeric : CK(2995) : AC(1585)
Diseases : Leukemia: Chronic myelogenous leukemia (CML) : CK(28) : AC(18)
Pharmacological Actions : Nitric Oxide Inhibitor : CK(108) : AC(57)
Additional Keywords : Drug: Imatinib : CK(10) : AC(1), Drug Synergy : CK(327) : AC(147)

Statin drugs alter platelet function.

Pubmed Data : Eur J Clin Invest. 2002 Dec ;32(12):901-8. PMID: 12534449
Article Published Date : Dec 01, 2002
Study Type : Human Study
Additional Links
Diseases : Blood Platelet Disorders : CK(20) : AC(2)
Pharmacological Actions : Nitric Oxide Inhibitor : CK(108) : AC(57)
Problem Substances : Atorvastatin : CK(491) : AC(90), Fluvastatin : CK(75) : AC(15), Pravastatin : CK(239) : AC(40), Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

American ginseng prevents and treats Ulcerative Colitis.

Pubmed Data : Carcinogenesis. 2008 Sep 18. [Epub ahead of print] PMID: 18802031
Article Published Date : Sep 18, 2008
Study Type : Animal Study
Additional Links
Substances : Ginseng (American) : CK(121) : AC(31)
Diseases : Colitis: Pseudomembranous : CK(8) : AC(7), Ulcerative Colitis : CK(429) : AC(39)
Pharmacological Actions : Cyclooxygenase 2 Inhibitors : CK(269) : AC(169), Nitric Oxide Inhibitor : CK(108) : AC(57), Tumor Suppressor Protein p53 Upregulation : CK(163) : AC(105)

Avocado/soybean unsaponifiables have a protective effect against experimental dog osteoarthritis.

Pubmed Data : Arthritis Res Ther. 2009;11(2):R41. Epub 2009 Mar 16. PMID: 19291317
Article Published Date : Jan 01, 2009
Study Type : Animal Study
Additional Links
Substances : Avocado : CK(47) : AC(17), Soy : CK(1688) : AC(350), Unsaponifiables : CK(25) : AC(6), Vitamin E : CK(1285) : AC(221)
Diseases : Osteoarthritis : CK(615) : AC(91)
Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71), Nitric Oxide Inhibitor : CK(108) : AC(57)
Additional Keywords : Plant Extracts : CK(3616) : AC(1226)

Bay leaf contains compounds which inhibit LPS-activated nitric oxide production and which induce heat shock protein.

Pubmed Data : Life Sci. 2000 Apr 21;66(22):2151-7. PMID: 10834299
Article Published Date : Apr 21, 2000
Study Type : Animal Study
Additional Links
Substances : Bay leaf : CK(55) : AC(27)
Diseases : Lipopolysaccharide-Induced Toxicity : CK(227) : AC(128)
Pharmacological Actions : Enzyme Inhibitors : CK(372) : AC(208), Heat Shock Protein Inducer : CK(51) : AC(17), Nitric Oxide Inhibitor : CK(108) : AC(57)

Chinese skullcap (Scutellaria baicalensis) significantly improves functional recovery from spinal cord injury in rats by inhibiting inflammation and oxidative stress after injury.

Pubmed Data : J Neurochem. 2009 Aug;110(4):1276-87. Epub 2009 Jun 10. PMID: 19519665
Article Published Date : Aug 01, 2009
Study Type : Animal Study
Additional Links
Substances : Chinese Skullcap : CK(97) : AC(57)
Diseases : Brain: Microglial Activation : CK(67) : AC(38), Spinal Cord Injuries : CK(98) : AC(28)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Antioxidants : CK(3653) : AC(1318), Apoptotic : CK(1535) : AC(1155), Cyclooxygenase 2 Inhibitors : CK(269) : AC(169), Interleukin-1 beta downregulation : CK(177) : AC(70), Interleukin-6 Downregulation : CK(470) : AC(135), Neuroprotective Agents : CK(962) : AC(480), Nitric Oxide Inhibitor : CK(108) : AC(57)
Additional Keywords : Plant Extracts : CK(3616) : AC(1226)

Curcumin attenuates ovalbumin-induced airway inflammation.

Pubmed Data : Biochem Biophys Res Commun. 2008 Oct 17;375(2):275-9. Epub 2008 Aug 13. PMID: 18706396
Article Published Date : Oct 17, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2923) : AC(1482)
Diseases : Allergic Airway Diseases : CK(41) : AC(17), Asthma : CK(918) : AC(134)
Pharmacological Actions : Nitric Oxide Inhibitor : CK(108) : AC(57)

Curcumin inhibits nitric oxide production.

Pubmed Data : Biochem Pharmacol. 1998 Jun 15;55(12):1955-62. PMID: 9714315
Article Published Date : Jun 15, 1998
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2923) : AC(1482)
Pharmacological Actions : Nitric Oxide Inhibitor : CK(108) : AC(57)

Curcumin prevents colon carcinogenesis.

Pubmed Data : Carcinogenesis. 1999 Apr;20(4):641-4. PMID: 10223193
Article Published Date : Apr 01, 1999
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2923) : AC(1482)
Diseases : Colon Cancer : CK(895) : AC(233), Colon Polyps : CK(42) : AC(12)
Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Cyclooxygenase 2 Inhibitors : CK(269) : AC(169), Enzyme Inhibitors : CK(372) : AC(208), Nitric Oxide Inhibitor : CK(108) : AC(57)

Curcumin prevents shock-wave lithotripsy-induced renal injury.

Pubmed Data : Urol Res. 2009 Jun;37(3):159-64. Epub 2009 Apr 2. PMID: 19340419
Article Published Date : Jun 01, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2923) : AC(1482)
Diseases : Kidney Stones : CK(157) : AC(28), Shock wave lithotripsy (SWL)-induced damage : CK(2) : AC(1)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), NF-kappaB Inhibitor : CK(595) : AC(401), Nitric Oxide Inhibitor : CK(108) : AC(57)

Curcumin reduces nitric oxide formation and associated inflammation in the rat mammary gland.

Pubmed Data : J Exp Biol. 2009 Jan;212(Pt 2):163-8. PMID: 11020339
Article Published Date : Jan 01, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2923) : AC(1482)
Diseases : Breast Cancer : CK(2361) : AC(621), Lipopolysaccharide-Induced Toxicity : CK(227) : AC(128)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Antineoplastic Agents : CK(877) : AC(496), Antioxidants : CK(3653) : AC(1318), Nitric Oxide Inhibitor : CK(108) : AC(57)

Dietary omega-3 fatty acids positively modulate the substrate for post-operative atrial fibrillation in a canine cardiac surgery model.

Pubmed Data : Cardiovasc Res. 2011 Mar 1;89(4):852-61. Epub 2010 Nov 30. PMID: 21123218
Article Published Date : Mar 01, 2011
Study Type : Animal Study
Additional Links
Substances : Omega-3 Fatty Acids : CK(3333) : AC(319)
Diseases : Atrial Fibrillation : CK(441) : AC(45)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Nitric Oxide Inhibitor : CK(108) : AC(57)

Dietary supplementation of resveratrol attenuates chronic colonic inflammation in mice.

Pubmed Data : Asia Pac J Clin Nutr. 2010;19(1):142-50. PMID: 20132809
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol : CK(977) : AC(590), Stilbenes : CK(128) : AC(92)
Diseases : Inflammation : CK(1077) : AC(363), Ulcerative Colitis : CK(429) : AC(39)
Pharmacological Actions : Cyclooxygenase 2 Inhibitors : CK(269) : AC(169), Nitric Oxide Inhibitor : CK(108) : AC(57), P38 Mitogen-Activated Protein Kinase Modulator : CK(6) : AC(5), Prostaglandin E Synthase-1 (PGES-1) Down-Regulation : CK(2) : AC(1)

Fermented soybean has anti-inflammatory properties in the kidney of high-fat-fed rats.

Pubmed Data : J Ethnopharmacol. 1987 Jul;20(2):85-106. PMID: 21332402
Article Published Date : Jul 01, 1987
Study Type : Animal Study
Additional Links
Substances : Fermented Foods and Beverages : CK(670) : AC(133), Soy : CK(1688) : AC(350), Soy: Fermented : CK(97) : AC(24)
Diseases : Inflammation : CK(1077) : AC(363)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Cyclooxygenase Inhibitors : CK(64) : AC(32), NF-kappaB Inhibitor : CK(595) : AC(401), Nitric Oxide Inhibitor : CK(108) : AC(57), Vascular Cell Adhesion Molecule-1 Inhibitor : CK(94) : AC(24)

Ginger inhibits micoglial cell activiation associated with brain inflammation.

Pubmed Data : Food Chem Toxicol. 2009 Jun;47(6):1190-7. Epub 2009 Feb 20. PMID: 19233241
Article Published Date : Jun 01, 2009
Study Type : Animal Study
Additional Links
Substances : Ginger : CK(310) : AC(89)
Diseases : Brain: Microglial Activation : CK(67) : AC(38), Brain Inflammation : CK(79) : AC(35), Inflammation : CK(1077) : AC(363), Lipopolysaccharide-Induced Toxicity : CK(227) : AC(128), Neurodegenerative Diseases : CK(1743) : AC(420)
Pharmacological Actions : Cyclooxygenase 2 Inhibitors : CK(269) : AC(169), NF-kappaB Inhibitor : CK(595) : AC(401), Nitric Oxide Inhibitor : CK(108) : AC(57), Prostaglandin Antagonists : CK(27) : AC(13)

Honey has anti-inflammatory properties likely due to its nitric oxide inhibitory properties.

Pubmed Data : Zhong Xi Yi Jie He Xue Bao. 2011 Apr ;9(4):447-52. PMID: 21486559
Article Published Date : Apr 01, 2011
Study Type : Animal Study
Additional Links
Substances : Honey : CK(251) : AC(50)
Diseases : Inflammation : CK(1077) : AC(363)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Nitric Oxide Inhibitor : CK(108) : AC(57)

L-arginine may ameliorate gastrointestinal dysfunction in diabetic rats.

Pubmed Data : Nitric Oxide. 2009 Mar;20(2):129-33. Epub 2008 Nov 18. PMID: 19041728
Article Published Date : Mar 01, 2009
Study Type : Animal Study
Additional Links
Substances : Arginine : CK(970) : AC(169)
Diseases : Diabetes: Gastrointestinal dysfunction : CK(2) : AC(1)
Pharmacological Actions : Enzyme Inhibitors : CK(372) : AC(208), Nitric Oxide Inhibitor : CK(108) : AC(57)

L-arginine reduces mercury accumulation in thymus of mercury-exposed mice.

Pubmed Data : Ind Health. 2008 Dec;46(6):567-74. PMID: 19088408
Article Published Date : Dec 01, 2008
Study Type : Animal Study
Additional Links
Substances : Arginine : CK(970) : AC(169)
Diseases : Mercury Poisoning : CK(162) : AC(44)
Pharmacological Actions : Nitric Oxide Inhibitor : CK(108) : AC(57)

L-arginine supplementation reduces cardiac noradrenergic neurotransmission in spontaneously hypertensive rats.

Pubmed Data : J Mol Cell Cardiol. 2009 Jul;47(1):149-55. Epub 2009 Apr 9. PMID: 19362092
Article Published Date : Jul 01, 2009
Study Type : Animal Study
Additional Links
Substances : Arginine : CK(970) : AC(169)
Diseases : Cardiac noradrenergic hyperactivity : CK(2) : AC(1), Hypertension : CK(2783) : AC(271)
Pharmacological Actions : Nitric Oxide Inhibitor : CK(108) : AC(57)

L0arginine supplementation improves endothelial function and myocardial perfusion in a swine model of chronic myocardial ischemia.

Pubmed Data : Surgery. 2005 Aug;138(2):291-8. PMID: 16153439
Article Published Date : Aug 01, 2005
Study Type : Animal Study
Additional Links
Substances : Arginine : CK(970) : AC(169)
Diseases : Coronary Artery Disease : CK(1305) : AC(136), Endothelial Dysfunction : CK(897) : AC(173), High Cholesterol : CK(1718) : AC(198), Myocardial Ischemia : CK(87) : AC(37)
Pharmacological Actions : Nitric Oxide Inhibitor : CK(108) : AC(57)

Lotus has immunomodulatory effects.

Pubmed Data : Psychol Med. 2010 Jan 5:1-11. Epub 2010 Jan 5. PMID: 20095810
Article Published Date : Jan 05, 2010
Study Type : Animal Study
Additional Links
Substances : Lotus : CK(45) : AC(26)
Pharmacological Actions : Histamine Antagonists : CK(46) : AC(18), Immunomodulatory : CK(536) : AC(142), Nitric Oxide Inhibitor : CK(108) : AC(57)

Niacin could effectively attenuate the over expression of nitric oxide synthase in the rat lung induced by silica particles.

Pubmed Data : Zhonghua Yu Fang Yi Xue Za Zhi. 2004 May;38(3):186-9. PMID: 15182488
Article Published Date : May 01, 2004
Study Type : Animal Study
Additional Links
Substances : Niacin : CK(205) : AC(26)
Diseases : Pulmonary Fibrosis : CK(135) : AC(46)
Pharmacological Actions : Nitric Oxide Inhibitor : CK(108) : AC(57)

Noni, and its major bioactive component damnacanthal, exhibits anti-inflammatory properties.

Pubmed Data : Inflamm Allergy Drug Targets. 2011 Nov 1. Epub 2011 Nov 1. PMID: 21999179
Article Published Date : Nov 01, 2011
Study Type : Animal Study
Additional Links
Substances : Damnacanthal : CK(3) : AC(2), Noni : CK(83) : AC(42)
Diseases : Inflammation : CK(1077) : AC(363), Lipopolysaccharide-Induced Toxicity : CK(227) : AC(128)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Cyclooxygenase 2 Inhibitors : CK(269) : AC(169), NF-kappaB Inhibitor : CK(595) : AC(401), Nitric Oxide Inhibitor : CK(108) : AC(57)

Patchouli may provide gastrointestinal protection against trauma or surgical operation.

Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Jul;29(7):639-41. PMID: 19852300
Article Published Date : Jul 01, 2009
Study Type : Animal Study
Additional Links
Substances : Patchouli : CK(15) : AC(6)
Diseases : Bowel Surgery : CK(18) : AC(5), Colon Surgery : CK(19) : AC(6), Gastrointestinal Diseases : CK(38) : AC(14), Short Bowel Syndrome : CK(32) : AC(8)
Pharmacological Actions : Nitric Oxide Inhibitor : CK(108) : AC(57), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Resveratrol and curcumin may combine with insulin in attenuating diabetic neuropathic pain.

Pubmed Data : Phytother Res. 2007 Mar;21(3):278-83. PMID: 17199240
Article Published Date : Mar 01, 2007
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2923) : AC(1482), Resveratrol : CK(977) : AC(590)
Diseases : Diabetic Neuropathies : CK(203) : AC(32), Pain : CK(616) : AC(91)
Pharmacological Actions : Nitric Oxide Inhibitor : CK(108) : AC(57), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)
Additional Keywords : Plant Extracts : CK(3616) : AC(1226), Stilbenes : CK(402) : AC(242)

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