Radiosensitizer

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View the Evidence: Pharmacological Actions

Selaginella may induce radiosensitization on nasopharyngeal carcinoma and may reduce acute toxicity to healthy tissue..

Pubmed Data : Nan Fang Yi Ke Da Xue Xue Bao. 2006 Feb;26(2):247-8. PMID: 16503545
Article Published Date : Feb 01, 2006
Study Type : Human Study
Additional Links
Diseases : Nasopharyngeal Cancer : CK(58) : AC(21), Skin Cancer: Squamous Cell : CK(52) : AC(16)
Pharmacological Actions : Drug synergy : CK(51) : AC(12), Radiosensitizer : CK(50) : AC(29)

Tea polyphenol has potential to be a therapeutic adjuvant against human metastatic breast cancer.

Pubmed Data : Curr Mol Med. 2012 Feb 1 ;12(2):163-76. PMID: 22280355
Article Published Date : Feb 01, 2012
Study Type : Human Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(859) : AC(109)
Diseases : Breast Cancer : CK(2354) : AC(621), Breast Cancer: Metastatic : CK(82) : AC(33)
Pharmacological Actions : Anti-metastatic : CK(192) : AC(115), Radiosensitizer : CK(50) : AC(29)
Additional Keywords : Drug Synergy : CK(327) : AC(147)

Curcumin has anticancer, chemosensitization and radiosensitization effects in prostate cancer.

Pubmed Data : Cancer Res. 2007 Mar 1;67(5):1988-96. PMID: 17332326
Article Published Date : Mar 01, 2007
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Cancers: Drug Resistant : CK(225) : AC(147), Prostate Cancer : CK(998) : AC(288)
Pharmacological Actions : Chemosensitizer : CK(197) : AC(159), Radiosensitizer : CK(50) : AC(29), Tumor Suppressor Protein p53 Upregulation : CK(146) : AC(105)
Additional Keywords : Drug: Gemcitabine : CK(36) : AC(13), Drug Synergy : CK(327) : AC(147)

Curcumin is a potential radio-enhancer in head and neck cancer.

Pubmed Data : Laryngoscope. 2009 Oct;119(10):2019-26. PMID: 19655336
Article Published Date : Oct 01, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Head and Neck Cancer : CK(36) : AC(14), Squamous cell carcinoma : CK(79) : AC(36)
Pharmacological Actions : Radiosensitizer : CK(50) : AC(29)

Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation.

Pubmed Data : Clin Cancer Res. 2008 Apr 1;14(7):2128-36. PMID: 18381954
Article Published Date : Apr 01, 2008
Study Type : Transgenic Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Colorectal Cancer : CK(877) : AC(321)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), NF-kappaB Inhibitor : CK(595) : AC(401), Radiosensitizer : CK(50) : AC(29)
Additional Keywords : Radiation Synergy : CK(12) : AC(2)

"Resveratrol enhances prostate cancer cell response to ionizing radiation."

Pubmed Data : Radiat Oncol. 2011 ;6:144. Epub 2011 Oct 26. PMID: 22029423
Article Published Date : Jan 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol : CK(977) : AC(590)
Diseases : Prostate Cancer : CK(998) : AC(288)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319), Radiosensitizer : CK(50) : AC(29)

2-Methoxyestradiol, an endogenous estrogen metabolite, sensitizes radioresistant breast cancer cells through multiple mechanisms.

Pubmed Data : Int J Radiat Oncol Biol Phys. 2011 May 1 ;80(1):231-9. Epub 2011 Mar 9. PMID: 21392897
Article Published Date : Apr 30, 2011
Study Type : In Vitro Study
Additional Links
Substances : 2-Methoxyestradiol : CK(1) : AC(1)
Diseases : Breast Cancer : CK(2354) : AC(621), Breast Cancer: Conventional Treatment : CK(14) : AC(1), Cancers: Radiation-Resistant : CK(7) : AC(1), DNA damage : CK(711) : AC(293), Radiation Induced Illness : CK(1018) : AC(249)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Bcl-2 protein down-regulation : CK(49) : AC(38), Cell cycle arrest : CK(390) : AC(319), Radiosensitizer : CK(50) : AC(29)

A number of plant polyphenols have chemosensitizing and radiosensitizing activity.

Pubmed Data : Antioxid Redox Signal. 2005 Nov-Dec;7(11-12):1630-47. PMID: 16356126
Article Published Date : Nov 01, 2005
Study Type : Review
Additional Links
Substances : Betulinic acid : CK(6) : AC(6), Caffeic acid phenethyl ester : CK(15) : AC(8), Curcumin : CK(2910) : AC(1482), Emodin : CK(32) : AC(19), Flavonoids : CK(909) : AC(289), Genistein : CK(450) : AC(174), Green Tea : CK(930) : AC(294), Polyphenols : CK(427) : AC(174), Resveratrol : CK(977) : AC(590), Silymarin : CK(36) : AC(8), Ursolic Acid : CK(18) : AC(12)
Diseases : Cancers: Drug Resistant : CK(225) : AC(147)
Pharmacological Actions : Chemosensitizer : CK(197) : AC(159), Radiosensitizer : CK(50) : AC(29)

A variety of natural substances may function as novel anticancer agents, proteasome inhibitors and chemosensitizers.

Pubmed Data : Drug Resist Updat. 2006 Dec;9(6):263-73. Epub 2007 Jan 2. PMID: 17197231
Article Published Date : Dec 01, 2006
Study Type : Review
Additional Links
Substances : Catechin : CK(403) : AC(130), Curcumin : CK(2910) : AC(1482), Genistein : CK(450) : AC(174), Resveratrol : CK(977) : AC(590)
Diseases : Cancers: Drug Resistant : CK(225) : AC(147)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Chemosensitizer : CK(197) : AC(159), Proteasome Inhibitors : CK(41) : AC(27), Radiosensitizer : CK(50) : AC(29)
Additional Keywords : Stilbenes : CK(402) : AC(242)

Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3.

Pubmed Data : Oncogene. 2004 Feb 26;23(8):1599-607. PMID: 14985701
Article Published Date : Feb 26, 2004
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Prostate Cancer : CK(998) : AC(288)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), NF-kappaB Inhibitor : CK(595) : AC(401), Radiosensitizer : CK(50) : AC(29), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Curcumin decreases survival of liver and breast cancer cells.

Pubmed Data : Strahlenther Onkol. 2011 Jul ;187(7):393-400. Epub 2011 Jun 27. PMID: 21713389
Article Published Date : Jul 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Breast Cancer : CK(2354) : AC(621), Hypoxia : CK(100) : AC(41), Liver Cancer : CK(1641) : AC(266)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Radiosensitizer : CK(50) : AC(29)

Curcumin exerts a synergistic effect with radiation against oral cancer cells.

Pubmed Data : Acta Odontol Scand. 2011 Feb 7. Epub 2011 Feb 7. PMID: 21294671
Article Published Date : Feb 07, 2011
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Oral Cancer : CK(66) : AC(43)
Pharmacological Actions : Radiosensitizer : CK(50) : AC(29)

Curcumin has radiosensitizing and chemosensitizing effects on tumors while protecting healthy tissue from damage.

Pubmed Data : Nutr Cancer. 2010 Oct;62(7):919-30. PMID: 20924967
Article Published Date : Oct 01, 2010
Study Type : Review
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Cancers: All : CK(9062) : AC(2869), Chemotherapy-Induced Toxicity : CK(704) : AC(184), Radiation Induced Illness : CK(1018) : AC(249), Tumors : CK(197) : AC(110)
Pharmacological Actions : Chemosensitizer : CK(197) : AC(159), Radiosensitizer : CK(50) : AC(29)

Curcumin improves the antitumor effect of X-ray irradiation.

Pubmed Data : Anticancer Drugs. 2012 Jan 23. Epub 2012 Jan 23. PMID: 22273827
Article Published Date : Jan 23, 2012
Study Type : In Vitro Study
Additional Links
Substances : Turmeric : CK(2995) : AC(1585)
Diseases : Burkitt Lymphoma : CK(10) : AC(9)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Radiosensitizer : CK(50) : AC(29)

Curcumin increases the radiosensitivity of colorectal cancer cells.

Pubmed Data : Int J Radiat Oncol Biol Phys. 2009 Oct 1;75(2):534-42. PMID: 19735878
Article Published Date : Oct 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Colon Cancer : CK(895) : AC(233), Colorectal Cancer : CK(877) : AC(321)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Enzyme Inhibitors : CK(372) : AC(208), NF-kappaB Inhibitor : CK(595) : AC(401), Radiosensitizer : CK(50) : AC(29)

Curcumin induces chemo/radio-sensitization in ovarian cancer cells and curcumin nanoparticles inhibit ovarian cancer cell growth.

Pubmed Data : J Ovarian Res. 2010;3:11. Epub 2010 Apr 29. PMID: 20429876
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Ovarian Cancer : CK(154) : AC(58)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Chemosensitizer : CK(197) : AC(159), Radiosensitizer : CK(50) : AC(29)

Curcumin is a potent radiosensitizer and may act by overcoming the effects of radiation-induced NFkappaB mediated pro-survival gene expression in neuroblastoma.

Pubmed Data : Cancer Biol Ther. 2008 Apr;7(4):569-76. Epub 2008 Jan 7. PMID: 18305409
Article Published Date : Apr 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Neuroblastoma : CK(52) : AC(31)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Apoptotic : CK(1489) : AC(1114), NF-kappaB Inhibitor : CK(595) : AC(401), Radiosensitizer : CK(50) : AC(29)

Curcumin is a radiosensitizer of human cervical tumor cells.

Pubmed Data : Mol Pharmacol. 2008 May;73(5):1491-501. Epub 2008 Feb 5. PMID: 18252805
Article Published Date : May 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Cervical Cancer : CK(363) : AC(69)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), NF-kappaB Inhibitor : CK(595) : AC(401), Radiosensitizer : CK(50) : AC(29)
Additional Keywords : Drug Synergy : CK(327) : AC(147)

Curcumin is a radiosensitizer of squamous cell carcinoma cells.

Pubmed Data : Otolaryngol Head Neck Surg. 2005 Feb;132(2):317-21. PMID: 15692547
Article Published Date : Feb 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Squamous cell carcinoma : CK(79) : AC(36)
Pharmacological Actions : Cell cycle arrest : CK(390) : AC(319), Radiosensitizer : CK(50) : AC(29)

Curcumin may be a potential radiosensitizing agent for enhanced antiangiogenic effect in colorectal cancer radiation therapy.

Pubmed Data : Am J Physiol Gastrointest Liver Physiol. 2010 Jun;298(6):G865-77. Epub 2010 Mar 18. PMID: 20299603
Article Published Date : Jun 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Colorectal Cancer : CK(877) : AC(321)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), NF-kappaB Inhibitor : CK(595) : AC(401), Radiosensitizer : CK(50) : AC(29)

Genistein acts as a radiosensitizing and chemosensitizing agent against the breast cancer cell line MCF-7.

Pubmed Data : Anticancer Res. 2009 Aug;29(8):3179-83. PMID: 19661332
Article Published Date : Aug 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Genistein : CK(450) : AC(174)
Diseases : Breast Cancer : CK(2354) : AC(621)
Pharmacological Actions : Chemosensitizer : CK(197) : AC(159), Radiosensitizer : CK(50) : AC(29)
Additional Keywords : Drug-Plant-Vitamin Synergies : CK(1011) : AC(268)

Luteolin has a radiosensitizing effect on human gastric cancer cells.

Pubmed Data : J Ethnopharmacol. 1990 Apr;29(1):95-103. PMID: 19589287
Article Published Date : Apr 01, 1990
Study Type : In Vitro Study
Additional Links
Substances : Luteolin : CK(62) : AC(51)
Diseases : Gastric Cancer : CK(373) : AC(111)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Radiosensitizer : CK(50) : AC(29), Vascular Endothelial Growth Factor A Inhibitor : CK(102) : AC(58)

Melatonin has radiosensitizing properties in leukemia cells and radioprotective properties in normal cells.

Pubmed Data : J Pineal Res. 2009 Sep;47(2):147-55. Epub 2009 Jun 23. PMID: 19555448
Article Published Date : Sep 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Melatonin : CK(470) : AC(131)
Diseases : Acute T cell Leukemias : CK(11) : AC(11)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Bcl-2 protein down-regulation : CK(49) : AC(38), Radioprotective : CK(456) : AC(183), Radiosensitizer : CK(50) : AC(29), Tumor Suppressor Protein p53 Upregulation : CK(146) : AC(105)

Propolis extract preferentially radiotoxic to medulloblastoma cells.

Pubmed Data : Childs Nerv Syst. 2008 Sep;24(9):987-94. Epub 2008 May 10. PMID: 18470517
Article Published Date : Sep 01, 2008
Study Type : In Vitro Study
Additional Links
Diseases : Medulloblastoma : CK(7) : AC(7), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), NF-kappaB Inhibitor : CK(595) : AC(401), Radiosensitizer : CK(50) : AC(29)

Resveratrol imparts photoprotection of normal cells and enhances the efficacy of radiation therapy in cancer cells.

Pubmed Data : Photochem Photobiol. 2008 Mar-Apr;84(2):415-21. Epub 2008 Jan 23. PMID: 18221451
Article Published Date : Mar 01, 2008
Study Type : Commentary
Additional Links
Substances : Resveratrol : CK(977) : AC(590)
Diseases : Photochemotherapy : CK(1) : AC(1), Radiation Induced Illness : CK(1018) : AC(249), Skin Diseases: Photo-Aging : CK(365) : AC(47)
Pharmacological Actions : Radiosensitizer : CK(50) : AC(29)

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