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Article Count - 90
Cumulative Knowledge - 197

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View the Evidence: Pharmacological Actions

A "very low dose" of omega-3 fatty acids slows renal progression in high-risk patients with IgA nephropathy.

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Pubmed Data : Ren Fail. 2004 Jul;26(4):453-9. PMID: 15462115

Article Published Date : Jul 01, 2004

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid) : CK(582) : AC(100), EPA (Eicosapentaenoic Acid) : CK(595) : AC(84), Omega-3 Fatty Acids : CK(3333) : AC(319)

Diseases : IgA Nephropathy : CK(186) : AC(22)

Pharmacological Actions : Renoprotective : CK(191) : AC(90)

A 12-month therapy with omega-3 fatty acids improves renal vascular function and tubule function in IgA nephropathy patients.

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Pubmed Data : Am J Nephrol. 2004 Sep-Oct;24(5):474-82. Epub 2004 Sep 1. PMID: 15340256

Article Published Date : Sep 01, 2004

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid) : CK(582) : AC(100), EPA (Eicosapentaenoic Acid) : CK(595) : AC(84), Omega-3 Fatty Acids : CK(3333) : AC(319)

Pharmacological Actions : Renoprotective : CK(191) : AC(90)

"Curcumin ameliorates cisplatin-induced nephrotoxicity by inhibiting renal inflammation in mice."

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Pubmed Data : J Biosci Bioeng. 2012 Dec 12. Epub 2012 Dec 12. PMID: 23245727

Article Published Date : Dec 11, 2012

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66), Chemotherapy-Induced Toxicity: Kidney : CK(8) : AC(4)

Pharmacological Actions : Renoprotective : CK(191) : AC(90)

Additional Keywords : Drug: Cisplatin : CK(31) : AC(11)

"Pomegranate Extract Attenuates Gentamicin-Induced Nephrotoxicity in Rats by Reducing Oxidative Stress."

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Pubmed Data : Ren Fail. 2012 Nov 26. Epub 2012 Nov 26. PMID: 23176634

Article Published Date : Nov 25, 2012

Study Type : Animal Study

Additional Links

Substances : Pomegranate : CK(146) : AC(61)

Diseases : Chemotherapy-Induced Toxicity: Gentamicin : CK(22) : AC(10), Kidney Damage: Chemically-Induced : CK(2) : AC(1)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Renoprotective : CK(191) : AC(90)

Additional Keywords : Drug: Gentamicin : CK(2) : AC(1)

Problem Substances : Gentamicin : CK(2) : AC(1)

Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

A Chinese formula Modified Simiao Decoction regulates renal urate transporters and enhancing antioxidant enzymes activities to improve renal dysfunction in hyperuricemic mice.

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Pubmed Data : J Ethnopharmacol. 2012 Jun 26 ;142(1):248-52. Epub 2012 May 8. PMID: 22575704

Article Published Date : Jun 25, 2012

Study Type : Animal Study

Additional Links

Substances : Chinese Medicine: Modified Simiao Decoction : CK(2) : AC(1)

Diseases : Hyperuricemia : CK(253) : AC(32), Uric Acid Nephropathy : CK(5) : AC(3)

Pharmacological Actions : Malondialdehyde Down-regulation : CK(76) : AC(21), Renoprotective : CK(191) : AC(90), Superoxide Dismutase Up-regulation : CK(131) : AC(42)

Additional Keywords : Phytotherapy : CK(177) : AC(27)

A compound in ginger known as 6-Gingerol prevents cisplatin-induced acute renal failure in rats.

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Pubmed Data : J Agric Food Chem. 2005 Apr 6;53(7):2446-50. PMID: 16971750

Article Published Date : Apr 06, 2005

Study Type : Animal Study

Additional Links

Substances : Catechols : CK(14) : AC(12), Ginger : CK(310) : AC(89)

Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Renoprotective : CK(191) : AC(90)

A compound in mangosteen prevents cisplatin-induced toxicity to the kidneys of rats.

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Pubmed Data : Chem Biol Interact. 2010 Oct 6;188(1):144-50. PMID: 20603111

Article Published Date : Oct 06, 2010

Study Type : Animal Study

Additional Links

Substances : Mangosteen : CK(42) : AC(20)

Diseases : Chemotherapy-Induced Toxicity : CK(704) : AC(184), Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66)

Pharmacological Actions : Renoprotective : CK(191) : AC(90)

Additional Keywords : Drug Side Effect Attenuation : CK(252) : AC(49)

A compound within Andrographis prevent diabetic nephropathy in an animal model.

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Pubmed Data : J Ethnopharmacol. 2010 Aug 30. Epub 2010 Aug 30. PMID: 20813180

Article Published Date : Aug 30, 2010

Study Type : Animal Study

Additional Links

Substances : Andrographis : CK(81) : AC(35)

Diseases : Diabetic Nephropathy : CK(43) : AC(17), Kidney Diseases : CK(424) : AC(71), Nephropathy: Diabetic : CK(4) : AC(2)

Pharmacological Actions : Renoprotective : CK(191) : AC(90)

A tocotrienol rich fraction of palm oil protects against chemically-induced kidney damage.

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Pubmed Data : Chem Biol Interact. 2010 Jul 30;186(2):228-38. Epub 2010 Apr 28. PMID: 20433818

Article Published Date : Jul 30, 2010

Study Type : Animal Study

Additional Links

Substances : Palm Oil : CK(30) : AC(16), Tocotrienols : CK(22) : AC(16)

Diseases : Kidney Damage : CK(120) : AC(42), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Renoprotective : CK(191) : AC(90)

Amla exhibits antihyperglycemic and hepato-renal protective properties in fluoride induced toxicity.

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Pubmed Data : J Pharm Bioallied Sci. 2012 Jul ;4(3):250-4. PMID: 22923969

Article Published Date : Jun 30, 2012

Study Type : Animal Study

Additional Links

Substances : Amla Fruit : CK(51) : AC(28)

Diseases : Fluoride Toxicity : CK(146) : AC(40)

Pharmacological Actions : Hepatoprotective : CK(557) : AC(272), Hypoglycemic Agents : CK(563) : AC(156), Renoprotective : CK(191) : AC(90)

Problem Substances : Fluoride : CK(264) : AC(45)

Astragalus has therapeutic properties in an animal model of IgA nephropathy.

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Pubmed Data : Zhongguo Dang Dai Er Ke Za Zhi. 2008 Apr;10(2):173-8. PMID: 18433541

Article Published Date : Apr 01, 2008

Study Type : Animal Study

Additional Links

Substances : Astragalus : CK(225) : AC(49)

Diseases : IgA Nephropathy : CK(186) : AC(22)

Pharmacological Actions : Renoprotective : CK(191) : AC(90)

Berberine protects against fructose-and-salt induced hypertensive renal injury.

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Pubmed Data : Zhong Yao Cai. 2011 Mar ;34(3):412-5. PMID: 21823461

Article Published Date : Mar 01, 2011

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Fructose-Induced Toxicity : CK(138) : AC(49), Hypertension: Renal : CK(2) : AC(1), Kidney Diseases : CK(424) : AC(71)

Pharmacological Actions : Renoprotective : CK(191) : AC(90)

Problem Substances : Fructose : CK(356) : AC(103), Sodium Chloride : CK(14) : AC(3)

Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

Curcumin ameliorates aflatoxin-induced changes in SDH and ATPase activities in liver and kidney of mice.

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Pubmed Data : Acta Pol Pharm. 2008 Jul-Aug;65(4):415-9. PMID: 19051581

Article Published Date : Jul 01, 2008

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Aflatoxicosis : CK(214) : AC(37), Liver Damage: Aflatoxin-Induced : CK(26) : AC(10)

Pharmacological Actions : Hepatoprotective : CK(557) : AC(272), Renoprotective : CK(191) : AC(90)

Curcumin ameliorates aflatoxin-induced lipid-peroxidation in liver and kidney of mice.

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Pubmed Data : Acta Pol Pharm. 2008 Mar-Apr;65(2):195-202. PMID: 18666425

Article Published Date : Mar 01, 2008

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Aflatoxicosis : CK(214) : AC(37), Cholesterol: Oxidation : CK(457) : AC(98), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Hepatoprotective : CK(557) : AC(272), Renoprotective : CK(191) : AC(90)

Curcumin ameliorates aflatoxin-induced toxicity in DNA, RNA and protein in liver and kidney of mice.

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Pubmed Data : Acta Pol Pharm. 2007 Nov-Dec;64(6):497-502. PMID: 18323242

Article Published Date : Nov 01, 2007

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Aflatoxicosis : CK(214) : AC(37)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Hepatoprotective : CK(557) : AC(272), Renoprotective : CK(191) : AC(90)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Curcumin ameliorates kidney lesions associated with diabetes.

Click here to read the entire abstract

Pubmed Data : Mol Cell Biochem. 1998 Apr;181(1-2):87-96. PMID: 9562245

Article Published Date : Apr 01, 1998

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Diabetes: Kidney Function : CK(75) : AC(22)

Pharmacological Actions : Renoprotective : CK(191) : AC(90)

Curcumin and especially tetrahydrocurcumin ameliorate oxidative stress-induced renal injury in mice.

Click here to read the entire abstract

Pubmed Data : J Nutr. 2001 Aug;131(8):2090-5. PMID: 11481399

Article Published Date : Aug 01, 2001

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482), Tetrahydrocurcumin : CK(37) : AC(20)

Diseases : Kidney Damage : CK(120) : AC(42), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Antioxidants : CK(3653) : AC(1318), Renoprotective : CK(191) : AC(90)

Curcumin attenuates cyclosporine-induced renal dysfunction and oxidative stress in rat kidneys.

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Pubmed Data : BMC Pharmacol. 2005;5:15. Epub 2005 Oct 15. PMID: 16225695

Article Published Date : Jan 01, 2005

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Drug-Induced Toxicity: Cyclosporine : CK(6) : AC(3), Kidney Damage: Drug-Induced : CK(86) : AC(22), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Renoprotective : CK(191) : AC(90)

Curcumin attenuates gentamicin-induced kidney oxidative damage in rats.

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2006 Sep;44(9):1443-8. Epub 2006 May 20. PMID: 16814915

Article Published Date : Sep 01, 2006

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Chemotherapy-Induced Toxicity: Gentamicin : CK(22) : AC(10), Kidney Damage: Drug-Induced : CK(86) : AC(22), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Anti-Bacterial Agents : CK(970) : AC(316), Antioxidants : CK(3653) : AC(1318), Renoprotective : CK(191) : AC(90)

Additional Keywords : Drug: Gentamicin : CK(2) : AC(1), Gentamicin : CK(4) : AC(2)

Curcumin attenuates lipopolysaccharide-induced renal inflammation.

Click here to read the entire abstract

Pubmed Data : Biol Pharm Bull. 2011;34(2):226-32. PMID: 21415532

Article Published Date : Jan 01, 2011

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Inflammatory Kidney Diseases : CK(3) : AC(2), Kidney Infection : CK(10) : AC(5), Lipopolysaccharide-Induced Toxicity : CK(227) : AC(128)

Pharmacological Actions : Renoprotective : CK(191) : AC(90)

Curcumin attenuates oxidative damage in animals treated with a renal carcinogen, ferric nitrilotriacetate (Fe-NTA).

Click here to read the entire abstract

Pubmed Data : Mol Cell Biochem. 2009 Apr;324(1-2):157-64. Epub 2009 Jan 23. PMID: 19165575

Article Published Date : Apr 01, 2009

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Chemical Exposure : CK(49) : AC(15), Kidney Damage : CK(120) : AC(42), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Chemopreventive : CK(1528) : AC(382), Renoprotective : CK(191) : AC(90)

Curcumin attenuates renal fibrosis in rat obstructive nephropathy.

Click here to read the entire abstract

Pubmed Data : Urology. 2006 Feb;67(2):440-6. PMID: 16461119

Article Published Date : Feb 01, 2006

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Kidney Fibrosis : CK(10) : AC(5), Obstructive Nephropathy : CK(2) : AC(1)

Pharmacological Actions : NF-kappaB Inhibitor : CK(595) : AC(401), Renoprotective : CK(191) : AC(90)

Curcumin blocks fibrosis in anti-Thy 1 glomerulonephritis.

Click here to read the entire abstract

Pubmed Data : Kidney Int. 2005 Nov;68(5):2042-9. PMID: 16221204

Article Published Date : Nov 01, 2005

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Glomerulonephritis : CK(41) : AC(9), Kidney Fibrosis : CK(10) : AC(5), Proteinuria : CK(103) : AC(20)

Pharmacological Actions : Anti-Fibrotic : CK(30) : AC(19), Enzyme Inhibitors : CK(372) : AC(208), Renoprotective : CK(191) : AC(90)

Curcumin has a palliative action on gentamicin-induced nephrotoxicity in rats.

Click here to read the entire abstract

Pubmed Data : Fundam Clin Pharmacol. 2005 Aug;19(4):473-7. PMID: 16011735

Article Published Date : Aug 01, 2005

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Chemotherapy-Induced Toxicity: Gentamicin : CK(22) : AC(10), Kidney Damage: Drug-Induced : CK(86) : AC(22)

Pharmacological Actions : Renoprotective : CK(191) : AC(90)

Curcumin may have beneficial anti-angiogenic and protective properties in kidneys of diabetics.

Click here to read the entire abstract

Pubmed Data : J Med Assoc Thai. 2010 Feb;93 Suppl 2:S1-8. PMID: 21302394

Article Published Date : Feb 01, 2010

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Diabetes: Kidney Function : CK(75) : AC(22)

Pharmacological Actions : Anti-Angiogenic : CK(143) : AC(101), Renoprotective : CK(191) : AC(90)

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