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Article Count - 90
Cumulative Knowledge - 197

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View the Evidence: Pharmacological Actions

Sulforaphane prevents cell death and inflammation in nephropathy.

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Pubmed Data : J Nutr Biochem. 2011 Jun 16. Epub 2011 Jun 16. PMID: 21684138

Article Published Date : Jun 16, 2011

Study Type : Animal Study

Additional Links

Substances : Sulforaphane : CK(520) : AC(171)

Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66), Nephropathy : CK(164) : AC(31)

Pharmacological Actions : Renoprotective : CK(191) : AC(90)

Problem Substances : Cisplatin : CK(24) : AC(7)

Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

Sulforaphane protects against cisplatin-induced nephrotoxicity.

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Pubmed Data : Int J Sport Nutr Exerc Metab. 2007 Aug;17(4):352-63. PMID: 19913604

Article Published Date : Aug 01, 2007

Study Type : Animal Study

Additional Links

Substances : Sulforaphane : CK(520) : AC(171)

Diseases : Chemotherapy-Induced Toxicity : CK(704) : AC(184), Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Antineoplastic Agents : CK(877) : AC(496), Apoptotic : CK(1489) : AC(1114), Renoprotective : CK(191) : AC(90)

Taurine has a protective effect against cisplatin-induced nephrotoxicity in rats.

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Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2007 May;32(9):835-9. PMID: 11901256

Article Published Date : May 01, 2007

Study Type : Animal Study

Additional Links

Substances : Taurine : CK(145) : AC(33)

Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66), Kidney Damage: Drug-Induced : CK(86) : AC(22)

Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antioxidants : CK(3653) : AC(1318), Renoprotective : CK(191) : AC(90)

Tetrahydrocurcumin has a protective effect on hepatic and renal functional markers and protein levels in experimental type 2 diabetic rats.

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Pubmed Data : Basic Clin Pharmacol Toxicol. 2007 Oct;101(4):241-5. PMID: 17845505

Article Published Date : Oct 01, 2007

Study Type : Animal Study

Additional Links

Substances : Tetrahydrocurcumin : CK(37) : AC(20)

Diseases : Diabetes: Kidney Function : CK(75) : AC(22), Diabetes: Liver Disease : CK(10) : AC(4), Diabetes Mellitus: Type 2 : CK(3429) : AC(341)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Hepatoprotective : CK(557) : AC(272), Renoprotective : CK(191) : AC(90)

Tetrahydrocurcumin protects against oxidative damage associated with chemical exposure.

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Pubmed Data : Basic Clin Pharmacol Toxicol. 2006 Nov;99(5):329-34. PMID: 17076682

Article Published Date : Nov 01, 2006

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Kidney Damage : CK(120) : AC(42), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Renoprotective : CK(191) : AC(90)

The Ayurvedic medicine Salacia oblonga (and the compound mangiferin) attenuates diabetic renal fibrosis in rats.

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Pubmed Data : Evid Based Complement Alternat Med. 2009 Aug 25. Epub 2009 Aug 25. PMID: 19706694

Article Published Date : Aug 25, 2009

Study Type : Animal Study

Additional Links

Substances : Mangiferin : CK(42) : AC(27), Salacia oblonga : CK(2) : AC(1)

Diseases : Diabetes: Kidney Function : CK(75) : AC(22), Renal Fibrosis : CK(4) : AC(2), Renal tubulointerstitial fibrosis : CK(15) : AC(7)

Therapeutic Actions : Ayurvedic Medicine : CK(63) : AC(4)

Pharmacological Actions : Angiotensin-Converting Enzyme Inhibitors : CK(20) : AC(12), Anti-Fibrotic : CK(30) : AC(19), Renoprotective : CK(191) : AC(90)

The reduced form of coenzyme Q10 may prevent or minimize cyclosporine nephrotoxicity by an antioxidant effect.

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Pubmed Data : Exp Clin Transplant. 2012 Nov 28. Epub 2012 Nov 28. PMID: 23194328

Article Published Date : Nov 27, 2012

Study Type : Animal Study

Additional Links

Substances : Ubiquinol : CK(106) : AC(20)

Diseases : Nephropathy : CK(164) : AC(31)

Pharmacological Actions : Renoprotective : CK(191) : AC(90)

Problem Substances : Cyclosporine : CK(2) : AC(0)

Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

Thymoquinone, a compound derived from black cumin, prevents the development of gentamicin-induced acute renal toxicity in rats.

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Pubmed Data : Clin Exp Pharmacol Physiol. 2007 May-Jun;34(5-6):399-405. PMID: 17439407

Article Published Date : May 01, 2007

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed) : CK(133) : AC(34), Thymoquinone : CK(3) : AC(1)

Diseases : Chemotherapy-Induced Toxicity: Gentamicin : CK(22) : AC(10), Chemotherapy-Induced Toxicity: Kidney : CK(8) : AC(4), Kidney Damage : CK(120) : AC(42), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Renoprotective : CK(191) : AC(90)

Tocotrienol rich fractions of palm oil and rice bran oil protect against kidney damage associated with high blood sugar in type 1 diabetes.

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Pubmed Data : Chem Biol Interact. 2010 Dec 5;188(3):651-8. Epub 2010 Sep 28. PMID: 20816776

Article Published Date : Dec 05, 2010

Study Type : Animal Study

Additional Links

Substances : Palm Oil : CK(30) : AC(16), Rice Bran : CK(29) : AC(14), Tocotrienols : CK(22) : AC(16)

Diseases : Diabetes Mellitus: Type 1: Prevention : CK(197) : AC(30), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Hypoglycemic Agents : CK(563) : AC(156), Renoprotective : CK(191) : AC(90)

Turmeric reduces t(3)-induced oxidative stress and hyperplasia in the rat kidney.

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Pubmed Data : Indian J Clin Biochem. 2010 Oct ;25(4):393-7. Epub 2010 Oct 8. PMID: 21966112

Article Published Date : Oct 01, 2010

Study Type : Animal Study

Additional Links

Diseases : Kidney Hyperplasia : CK(2) : AC(1), T3-Induced Pathologies : CK(2) : AC(1)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Renoprotective : CK(191) : AC(90)

Turmeric-based diet may provide protection against fibrosis and apoptosis elicited unilateral ureteral obstruction (UUO).

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Pubmed Data : J Pharm Pharmacol. 2008 Jan;60(1):83-9. PMID: 18088509

Article Published Date : Jan 01, 2008

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Kidney Damage : CK(120) : AC(42)

Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), NF-kappaB Inhibitor : CK(595) : AC(401), Renoprotective : CK(191) : AC(90), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Vitamin C, E and melatonin ameliorate insecticide-induced nephrotoxicity in rats.

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Pubmed Data : Hum Exp Toxicol. 2002 Apr;21(4):223-30. PMID: 12099624

Article Published Date : Apr 01, 2002

Study Type : Animal Study

Additional Links

Substances : Melatonin : CK(470) : AC(131), Vitamin C : CK(1274) : AC(238), Vitamin E : CK(1285) : AC(221)

Diseases : Oxidative Stress : CK(1945) : AC(710), Pesticide Toxicity : CK(147) : AC(45)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Renoprotective : CK(191) : AC(90)

Wen-pi-tang-Hab-Wu-ling-san reduces ureteral obstructive renal fibrosis by the reduction of oxidative stress, inflammation, and TGF-beta/Smad2/3 signaling.

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Pubmed Data : Food Chem Toxicol. 2010 Feb;48(2):522-9. Epub 2009 Nov 11. PMID: 19913069

Article Published Date : Feb 01, 2010

Study Type : Animal Study

Additional Links

Substances : Traditional Chinese Medicine: Wen-pi-tang-Hab-Wu-ling-san : CK(2) : AC(1)

Diseases : Kidney Fibrosis : CK(10) : AC(5), Obstructive uropathy : CK(19) : AC(5), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Renoprotective : CK(191) : AC(90)

Red wine polyphenols prevent cyclosporine-induced nephrotoxicity at the level of the intrinsic apoptotic pathway.

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Pubmed Data : Physiol Res. 2009;58(4):511-9. Epub 2008 Jul 25. PMID: 18656999

Article Published Date : Jan 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174), Red Wine Extract : CK(59) : AC(25)

Diseases : Hypertension : CK(2783) : AC(271), Kidney Damage: Drug-Induced : CK(86) : AC(22), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Renoprotective : CK(191) : AC(90)

Sulforaphane can be used as an effective adjunct for the prevention of renal oxidative insults during ischemia-reperfusion injury.

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Pubmed Data : Biochem Pharmacol. 2008 Jun 1;75(11):2214-23. Epub 2008 Mar 4. PMID: 18407246

Article Published Date : Jun 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Sulforaphane : CK(520) : AC(171)

Diseases : Kidney Damage : CK(120) : AC(42)

Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Phase II Detoxification Enzyme Inducer : CK(64) : AC(32), Renoprotective : CK(191) : AC(90)

Sulforaphane protects against cisplatin-induced mitochondrial alterations associated with renal damage.

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Pubmed Data : Toxicol Lett. 2010 Nov 10;199(1):80-92. Epub 2010 Aug 21. PMID: 20732396

Article Published Date : Nov 10, 2010

Study Type : In Vitro Study

Additional Links

Substances : Sulforaphane : CK(520) : AC(171)

Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66), Mitochondrial Diseases : CK(149) : AC(50)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Antineoplastic Agents : CK(877) : AC(496), Apoptotic : CK(1489) : AC(1114), Enzyme Inhibitors : CK(372) : AC(208), Renoprotective : CK(191) : AC(90)

Additional Keywords : Drug: Cisplatin : CK(31) : AC(11)

Turmeric prevents oxidative stress induced kidney cell damage.

Click here to read the entire abstract

Pubmed Data : Free Radic Biol Med. 1998 Jan 1;24(1):49-54. PMID: 9436613

Article Published Date : Jan 01, 1998

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482), Turmeric : CK(2995) : AC(1585)

Diseases : Kidney Damage : CK(120) : AC(42), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Renoprotective : CK(191) : AC(90)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Vitamin C and E inhibit the toxicity of para-phenylenediamine in dog kidney cells.

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Pubmed Data : Toxicol In Vitro. 2010 Jun;24(4):1197-202. Epub 2010 Feb 13. PMID: 20156547

Article Published Date : Jun 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Vitamin C : CK(1274) : AC(238), Vitamin E : CK(1285) : AC(221)

Diseases : DNA damage : CK(711) : AC(293), Oxidative Stress : CK(1945) : AC(710), Para-phenylenediamine Induced Toxicity : CK(11) : AC(2)

Pharmacological Actions : Renoprotective : CK(191) : AC(90)

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