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Superoxide Dismutase Up-regulation

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Article Count - 42
Cumulative Knowledge - 134

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View the Evidence: Pharmacological Actions

Cynanchum auriculatum in combination with vitamin E exhibits anti-aging properties.

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Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2007 Dec;32(23):2511-4. PMID: 18330246

Article Published Date : Dec 01, 2007

Study Type : Meta Analysis

Additional Links

Substances : Cynanchum Auriculatum : CK(20) : AC(1), Vitamin E : CK(1285) : AC(221)

Diseases : Aging : CK(1351) : AC(369)

Pharmacological Actions : Malondialdehyde Down-regulation : CK(76) : AC(21), Superoxide Dismutase Up-regulation : CK(131) : AC(42), Telomerase Upregulation : CK(81) : AC(25)

A multi-herbal product called Protandim has significant antioxidant properties in human subjects.

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Pubmed Data : Arzneimittelforschung. 2006;56(6):387-93. PMID: 16413416

Article Published Date : Jan 01, 2006

Study Type : Human Study

Additional Links

Substances : Ashwagandha : CK(137) : AC(63), Bacopa : CK(47) : AC(18), Green Tea : CK(930) : AC(294), Milk Thistle : CK(226) : AC(55), Protandim : CK(20) : AC(7), Turmeric : CK(2995) : AC(1585)

Diseases : Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Catalase Up-Regulation : CK(22) : AC(8), Superoxide Dismutase Up-regulation : CK(131) : AC(42)

Astaxanthin prevents in vitro auto-oxidative injury in human lymphocytes.

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Pubmed Data : Cell Biol Toxicol. 2010 Oct;26(5):457-67. Epub 2010 Mar 14. PMID: 20229275

Article Published Date : Oct 01, 2010

Study Type : Human Study

Additional Links

Substances : Astaxanthin : CK(353) : AC(117)

Diseases : Immune Disorders: Low Immune Function : CK(488) : AC(115), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Apoptotic : CK(1489) : AC(1114), NF-kappaB Inhibitor : CK(595) : AC(401), Superoxide Dismutase Up-regulation : CK(131) : AC(42)

Astaxanthin protects smokers against oxidative stress.

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Pubmed Data : J Med Food. 2011 Sep 1. Epub 2011 Sep 1. PMID: 21883001

Article Published Date : Sep 01, 2011

Study Type : Human Study

Additional Links

Substances : Astaxanthin : CK(353) : AC(117)

Diseases : Lipid Peroxidation : CK(403) : AC(127), Oxidative Stress : CK(1945) : AC(710), Smoking : CK(577) : AC(86)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Isoprostane Down-Regulation : CK(10) : AC(1), Malonaldehyde (MDA) Down-Regulation : CK(20) : AC(6), Superoxide Dismutase Up-regulation : CK(131) : AC(42)

Problem Substances : Tobacco: Smoking : CK(125) : AC(12)

Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79), Oxidant : CK(104) : AC(37)

Oral administration of L-arginine in patients with angina or following myocardial infarction may be protective.

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Pubmed Data : Oxid Med Cell Longev. 2009 Sep-Oct;2(4):231-7. PMID: 20716909

Article Published Date : Sep 01, 2009

Study Type : Human Study

Additional Links

Substances : Arginine : CK(970) : AC(169)

Diseases : Heart Attack: Recovery : CK(22) : AC(3), Myocardial Infarction : CK(2632) : AC(117)

Pharmacological Actions : Cardioprotective : CK(702) : AC(196), Hypolipidemic : CK(370) : AC(80), Superoxide Dismutase Up-regulation : CK(131) : AC(42), Xanthine oxidase inhibitor : CK(25) : AC(11)

Whole body cryotherapy appears to reduce oxidative stress in multiple sclerosis patients.

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Pubmed Data : Pol Merkur Lekarski. 2011 Sep ;31(183):150-3. PMID: 21991843

Article Published Date : Sep 01, 2011

Study Type : Human Study

Additional Links

Diseases : Multiple Sclerosis : CK(716) : AC(133), Oxidative Stress : CK(1945) : AC(710)

Therapeutic Actions : Cryotherapy : CK(10) : AC(1)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Superoxide Dismutase Up-regulation : CK(131) : AC(42)

"Suppression by fucoidan of liver fibrogenesis via the TGF-β/Smad pathway in protecting against oxidative stress."

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Pubmed Data : Biosci Biotechnol Biochem. 2011 ;75(5):833-40. Epub 2011 May 20. PMID: 21597183

Article Published Date : Dec 31, 2010

Study Type : Animal Study

Additional Links

Substances : Fucoidan : CK(152) : AC(72)

Diseases : Liver Cirrhosis : CK(216) : AC(32), Liver Fibrosis : CK(341) : AC(74), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Malondialdehyde Down-regulation : CK(76) : AC(21), Superoxide Dismutase Up-regulation : CK(131) : AC(42)

A Chinese formula Modified Simiao Decoction regulates renal urate transporters and enhancing antioxidant enzymes activities to improve renal dysfunction in hyperuricemic mice.

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Pubmed Data : J Ethnopharmacol. 2012 Jun 26 ;142(1):248-52. Epub 2012 May 8. PMID: 22575704

Article Published Date : Jun 25, 2012

Study Type : Animal Study

Additional Links

Substances : Chinese Medicine: Modified Simiao Decoction : CK(2) : AC(1)

Diseases : Hyperuricemia : CK(253) : AC(32), Uric Acid Nephropathy : CK(5) : AC(3)

Pharmacological Actions : Malondialdehyde Down-regulation : CK(76) : AC(21), Renoprotective : CK(191) : AC(90), Superoxide Dismutase Up-regulation : CK(131) : AC(42)

Additional Keywords : Phytotherapy : CK(177) : AC(27)

A multi-herbal product called Protandim exhibits chemopreventive properties in a mouse model of skin cancer.

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Pubmed Data : PLoS One. 2010;5(7):e11902. Epub 2010 Jul 30. PMID: 20689586

Article Published Date : Jan 01, 2010

Study Type : Animal Study

Additional Links

Substances : Ashwagandha : CK(137) : AC(63), Bacopa : CK(47) : AC(18), Green Tea : CK(930) : AC(294), Milk Thistle : CK(226) : AC(55), Protandim : CK(20) : AC(7), Turmeric : CK(2995) : AC(1585)

Diseases : Skin Cancer : CK(417) : AC(171)

Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Chemopreventive : CK(1528) : AC(382), Superoxide Dismutase Up-regulation : CK(131) : AC(42), Tumor Suppressor Protein p53 Upregulation : CK(146) : AC(105)

A multi-herbal product called Protandim has chemopreventive properties against skin cancer.

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Pubmed Data : PLoS One. 2009;4(4):e5284. Epub 2009 Apr 22. PMID: 19384424

Article Published Date : Jan 01, 2009

Study Type : Animal Study

Additional Links

Substances : Ashwagandha : CK(137) : AC(63), Bacopa : CK(47) : AC(18), Green Tea : CK(930) : AC(294), Milk Thistle : CK(226) : AC(55), Protandim : CK(20) : AC(7), Turmeric : CK(2995) : AC(1585)

Diseases : Oxidative Stress : CK(1945) : AC(710), Skin Cancer : CK(417) : AC(171)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), NF-kappa-B-inducing kinase (NIK) modulator : CK(3) : AC(2), Superoxide Dismutase Up-regulation : CK(131) : AC(42), Tumor Suppressor Protein p53 Upregulation : CK(146) : AC(105), Vascular Cell Adhesion Molecule-1 Inhibitor : CK(94) : AC(24)

Astaxanthin from H. pluvialis shows better bioavailability than beta-carotene and lutein and has significant antixoxidant properties.

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Pubmed Data : J Agric Food Chem. 2010 Aug 11;58(15):8553-9. PMID: 20681642

Article Published Date : Aug 11, 2010

Study Type : Animal Study

Additional Links

Substances : Astaxanthin : CK(353) : AC(117), Carotenoids : CK(1055) : AC(213)

Diseases : Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Catalase Up-Regulation : CK(22) : AC(8), Superoxide Dismutase Up-regulation : CK(131) : AC(42)

Astaxanthin has radioprotective properties against cobalt-60 gamma radiation induced oxidative stress and DNA damage.

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Pubmed Data : Wei Sheng Yan Jiu. 2011 Sep ;40(5):551-4. PMID: 22043699

Article Published Date : Sep 01, 2011

Study Type : Animal Study

Additional Links

Substances : Astaxanthin : CK(353) : AC(117)

Diseases : DNA damage : CK(711) : AC(293), Radiation Induced Illness : CK(1018) : AC(249), Radiation Induced Illness: Bone Marrow : CK(22) : AC(13)

Pharmacological Actions : Genoprotective : CK(116) : AC(48), Glutathione Peroxidase 1 (GPx1) Up-Regulation : CK(3) : AC(2), Malonaldehyde (MDA) Down-Regulation : CK(20) : AC(6), Radioprotective : CK(456) : AC(183), Superoxide Dismutase Up-regulation : CK(131) : AC(42)

Astaxanthin protects against cyclophosphamide-induced oxidative stress and DNA damage.

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Pubmed Data : Chem Biol Interact. 2009 Aug 14;180(3):398-406. Epub 2009 Apr 2. PMID: 19539803

Article Published Date : Aug 14, 2009

Study Type : Animal Study

Additional Links

Substances : Astaxanthin : CK(353) : AC(117)

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide : CK(27) : AC(10), DNA damage : CK(711) : AC(293), Lipid Peroxidation : CK(403) : AC(127), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Malondialdehyde Down-regulation : CK(76) : AC(21), Superoxide Dismutase Up-regulation : CK(131) : AC(42)

Catechin mitigates thyroxine-induced oxidative stress in the liver and testis of rats.

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Pubmed Data : J Med Case Reports. 2009;3:9295. Epub 2009 Nov 24. PMID: 20882757

Article Published Date : Jan 01, 2009

Study Type : Animal Study

Additional Links

Substances : Catechin : CK(403) : AC(130)

Diseases : Drug-Induced Toxicity: L-Thyroxine : CK(23) : AC(8), Lipid Peroxidation : CK(403) : AC(127), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Catalase Up-Regulation : CK(22) : AC(8), Superoxide Dismutase Up-regulation : CK(131) : AC(42)

Cistanche deserticola exhibits anti-aging properties in mice.

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Pubmed Data : Zhong Yao Cai. 2008 Sep;31(9):1385-8. PMID: 19180965

Article Published Date : Sep 01, 2008

Study Type : Animal Study

Additional Links

Substances : Cistanche deserticola : CK(2) : AC(1)

Diseases : Aging : CK(1351) : AC(369), Aging: Brain : CK(1747) : AC(68), Learning disorders : CK(154) : AC(36), Memory Loss : CK(113) : AC(32), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Malondialdehyde Down-regulation : CK(76) : AC(21), Superoxide Dismutase Up-regulation : CK(131) : AC(42)

Dandelion has antifibrotic activity in chemically-induced liver damage in mice.

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Pubmed Data : J Ethnopharmacol. 2010 Aug 9;130(3):569-77. Epub 2010 Jun 2. PMID: 20561925

Article Published Date : Aug 09, 2010

Study Type : Animal Study

Additional Links

Substances : Dandelion : CK(91) : AC(30)

Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Liver Fibrosis : CK(341) : AC(74), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Anti-Fibrotic : CK(30) : AC(19), Hepatoprotective : CK(557) : AC(272), Superoxide Dismutase Up-regulation : CK(131) : AC(42)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Dandelion protects against lipopolysaccharide-induced acute lung injury in mice.

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Pubmed Data : J Ethnopharmacol. 2010 Jul 20;130(2):392-7. Epub 2010 May 25. PMID: 20510343

Article Published Date : Jul 20, 2010

Study Type : Animal Study

Additional Links

Substances : Dandelion : CK(91) : AC(30)

Diseases : Lipopolysaccharide-Induced Toxicity : CK(227) : AC(128), Lung Injury: Acute : CK(32) : AC(11)

Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Interleukin-6 Downregulation : CK(470) : AC(135), Superoxide Dismutase Up-regulation : CK(131) : AC(42), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Fo ti (Polygonum multiflorum) has a protective effect on experimental colitis in mice.

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Pubmed Data : Eur J Pharmacol. 2008 Jan 14;578(2-3):339-48. Epub 2007 Oct 25. PMID:17963744

Article Published Date : Jan 14, 2008

Study Type : Animal Study

Additional Links

Substances : Fo ti : CK(3) : AC(4)

Diseases : Colitis: Pseudomembranous : CK(8) : AC(7)

Pharmacological Actions : Malonaldehyde (MDA) Down-Regulation : CK(20) : AC(6), Superoxide Dismutase Up-regulation : CK(131) : AC(42)

Ginger protects against dichlorvos and lindane induced oxidative stress in rat brain.

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Pubmed Data : Pharmacognosy Res. 2012 Jan ;4(1):27-32. PMID: 22224058

Article Published Date : Jan 01, 2012

Study Type : Animal Study

Additional Links

Substances : Ginger : CK(310) : AC(89)

Diseases : Brain Damage : CK(89) : AC(41)

Pharmacological Actions : Glutathione Upregulation : CK(144) : AC(48), Neuroprotective Agents : CK(962) : AC(480), Superoxide Dismutase Up-regulation : CK(131) : AC(42)

Problem Substances : Dichlorvos : CK(4) : AC(2), Lindane : CK(2) : AC(1)

Ginger protects against liver fibrosis.

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Pubmed Data : Nutr Metab (Lond). 2011 ;8:40. Epub 2011 Jun 20. PMID: 21689445

Article Published Date : Jan 01, 2011

Study Type : Animal Study

Additional Links

Substances : Ginger : CK(310) : AC(89)

Diseases : ALT: Elevated : CK(60) : AC(10), AST: Elevated : CK(26) : AC(4), Liver Fibrosis : CK(341) : AC(74)

Pharmacological Actions : Glutathione Upregulation : CK(144) : AC(48), Malonaldehyde (MDA) Down-Regulation : CK(20) : AC(6), Renoprotective : CK(191) : AC(90), Superoxide Dismutase Up-regulation : CK(131) : AC(42)

Glutamine and arginine supplementation may help prevent necrotizing enterocolitis.

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Pubmed Data : J Pediatr Gastroenterol Nutr. 2009 Jul;49(1):85-9. PMID: 19503000

Article Published Date : Jul 01, 2009

Study Type : Animal Study

Additional Links

Substances : Arginine : CK(970) : AC(169), Glutamine : CK(98) : AC(19)

Diseases : Necrotising enterocolitis : CK(79) : AC(12)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Malondialdehyde Down-regulation : CK(76) : AC(21), Superoxide Dismutase Up-regulation : CK(131) : AC(42)

L-arginine has potent in vitro and in vivo neuroprotective properties and may be a candidate for therapeutic trials in ALS.

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Pubmed Data : Biochem Biophys Res Commun. 2009 Jul 10;384(4):524-9. Epub 2009 May 8. PMID: 19427829

Article Published Date : Jul 10, 2009

Study Type : Animal Study

Additional Links

Substances : Arginine : CK(970) : AC(169)

Diseases : Amyotrophic Lateral Sclerosis : CK(350) : AC(68)

Pharmacological Actions : Neuroprotective Agents : CK(962) : AC(480), Superoxide Dismutase Up-regulation : CK(131) : AC(42)

L-arginine prevents endothelial dysfunction in rats with chronic renal failure.

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Pubmed Data : J Cardiovasc Pharmacol. 2007 Mar;49(3):131-9. PMID: 17414224

Article Published Date : Mar 01, 2007

Study Type : Animal Study

Additional Links

Substances : Arginine : CK(970) : AC(169)

Diseases : Endothelial Dysfunction : CK(897) : AC(173), Hypertension : CK(2783) : AC(271), Kidney Failure: Chronic : CK(134) : AC(19)

Pharmacological Actions : Superoxide Dismutase Up-regulation : CK(131) : AC(42), Vasodilator Agents : CK(262) : AC(54)

Additional Keywords : Drug Synergy : CK(327) : AC(147)

L-arginine protects against pulmonary oxidative stress and antioxidant defenses during exhaustive exercise in rats.

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Pubmed Data : Acta Pharmacol Sin. 2005 Aug;26(8):992-9. PMID: 16038634

Article Published Date : Aug 01, 2005

Study Type : Animal Study

Additional Links

Substances : Arginine : CK(970) : AC(169)

Diseases : Exercise-Induced Tissue Damage : CK(40) : AC(8), Lipid Peroxidation : CK(403) : AC(127), Lung Damage : CK(8) : AC(4), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Glutathione Upregulation : CK(144) : AC(48), Malondialdehyde Down-regulation : CK(76) : AC(21), Superoxide Dismutase Up-regulation : CK(131) : AC(42)

Lignan transformation by gut bacteria lowers tumor burden in a gnotobiotic rat model of breast cancer.

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Pubmed Data : Carcinogenesis. 2012 Jan ;33(1):203-8. Epub 2011 Nov 10. PMID: 22080573

Article Published Date : Dec 31, 2011

Study Type : Animal Study

Additional Links

Substances : Lignan-converting bacteria : CK(2) : AC(1), Lignans : CK(110) : AC(31), Secoisolariciresinol diglucoside (SDG) : CK(387) : AC(5)

Diseases : Breast Cancer : CK(2354) : AC(621)

Pharmacological Actions : Superoxide Dismutase Up-regulation : CK(131) : AC(42)

Additional Keywords : bacterial biotransformation

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