Telomerase Inhibitor

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View the Evidence: Pharmacological Actions

Childhood trauma is associated with accelerated aging (shortened telomere length) in post-traumatic stress disorder.

Pubmed Data : Biol Psychiatry. 2011 Apr 12. Epub 2011 Apr 12. PMID: 21489410
Article Published Date : Apr 12, 2011
Study Type : Human Study
Additional Links
Diseases : Aging : CK(1399) : AC(392), Childhood Trauma : CK(11) : AC(2), Post-Traumatic Stress Disorders (PTSD) : CK(136) : AC(17)
Pharmacological Actions : Telomerase Inhibitor : CK(41) : AC(23)
Additional Keywords : Psychobiology : CK(10) : AC(1)
Anti Therapeutic Actions : Childhood Trauma : CK(10) : AC(1)

Serum oxidized low-density lipoprotein is inversely correlated to telomerase activity in peripheral blood mononuclear cells of haemodialysis patients..

Pubmed Data : Nephrology (Carlton). 2006 Dec;11(6):506-9. PMID: 17199788
Article Published Date : Dec 01, 2006
Study Type : Human Study
Additional Links
Diseases : Aging : CK(1399) : AC(392), Atherosclerosis : CK(670) : AC(86), Cholesterol: Oxidation : CK(504) : AC(105), Hemodialysis : CK(363) : AC(39), Kidney Failure: Chronic : CK(134) : AC(18), Oxidative Stress : CK(2855) : AC(750)
Pharmacological Actions : Interleukin-10 downregulation : CK(75) : AC(23), Telomerase Inhibitor : CK(41) : AC(23), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1224) : AC(444)

A compound within Red Sage (tanshinone) induces programmed cell death in monocyte leukemia cells.

Pubmed Data : Int J Mol Sci. 2010;11(6):2267-80. Epub 2010 May 26. PMID: 20640151
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Red Sage : CK(121) : AC(37)
Diseases : Leukemia : CK(718) : AC(263)
Pharmacological Actions : Apoptotic : CK(2058) : AC(1476), Caspase-3 Activation : CK(73) : AC(15), Telomerase Inhibitor : CK(41) : AC(23)

A water extract of U. esculenta has a great potential to be developed into an anticancer agent that targets telomerase.

Pubmed Data : Int J Med Mushrooms. 2014 ;16(1):17-28. PMID: 24940901
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Lichens : CK(18) : AC(7), Mushrooms: All : CK(618) : AC(222)
Diseases : Gastric Cancer : CK(440) : AC(120)
Pharmacological Actions : Antiproliferative : CK(1752) : AC(1193), Telomerase Inhibitor : CK(41) : AC(23)
Additional Keywords : Plant Extracts : CK(5359) : AC(1705)

Chinese skullcap inhibits the growth of an estrogen-responsive mouse tumor cell line.

Pubmed Data : Oncol Rep. 2011 May;25(5):1431-8. Epub 2011 Mar 1. PMID: 21369700
Article Published Date : May 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Chinese Skullcap : CK(99) : AC(59)
Diseases : Cancers: Estrogen Responsive : CK(3) : AC(3), Testicular Cancer : CK(37) : AC(7), Testicular Neoplasms : CK(11) : AC(2)
Pharmacological Actions : Apoptotic : CK(2058) : AC(1476), Cell cycle arrest : CK(574) : AC(358), Cyclin-Dependent Kinase Inhibitor : CK(3) : AC(3), NF-kappaB Inhibitor : CK(763) : AC(499), Telomerase Inhibitor : CK(41) : AC(23)

Curcumin inhibits ionizing radiation-induced proliferation of human neuroblastoma cells.

Pubmed Data : Gynecol Endocrinol. 2010 Feb 23. Epub 2010 Feb 23. PMID: 21236599
Article Published Date : Feb 23, 2010
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(3785) : AC(1541)
Diseases : Neuroblastoma : CK(51) : AC(31)
Pharmacological Actions : Telomerase Inhibitor : CK(41) : AC(23)

Curcumin inhibits telomerase activity in breast ancer cells.

Pubmed Data : J Urol. 2011 Feb;185(2):719-24. Epub 2010 Dec 18. PMID: 12104041
Article Published Date : Feb 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(3785) : AC(1541)
Diseases : Breast Cancer : CK(2936) : AC(676)
Pharmacological Actions : Enzyme Inhibitors : CK(417) : AC(225), Telomerase Inhibitor : CK(41) : AC(23)

Curcumin inhibits telomerase activity in human cancer cell lines.

Pubmed Data : Int J Mol Med. 2006 Aug;18(2):227-31. PMID: 16820928
Article Published Date : Aug 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(3785) : AC(1541)
Diseases : Cancers: All : CK(11833) : AC(3016)
Pharmacological Actions : Antineoplastic Agents : CK(1055) : AC(505), Apoptotic : CK(2058) : AC(1476), Enzyme Inhibitors : CK(417) : AC(225), Telomerase Inhibitor : CK(41) : AC(23)

Curcumin inhibits telomerase and induces telomere shortening and apoptosis in brain tumour cells.

Pubmed Data : J Cell Biochem. 2012 Nov 28. Epub 2012 Nov 28. PMID: 23192708
Article Published Date : Nov 27, 2012
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(3785) : AC(1541)
Diseases : Brain Cancer : CK(262) : AC(96)
Pharmacological Actions : Telomerase Inhibitor : CK(41) : AC(23)

Curcumin inhibits telomerase expression associated with tumorigensis.

Pubmed Data : Cancer Lett. 2010 Apr 1;290(1):76-86. Epub 2009 Sep 13. PMID: 19751963
Article Published Date : Apr 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(3785) : AC(1541)
Diseases : Tumors : CK(200) : AC(116)
Pharmacological Actions : Antineoplastic Agents : CK(1055) : AC(505), Telomerase Inhibitor : CK(41) : AC(23)

Curcumin's induction of programmed cell death in human leukemia cells is associated with inhibition of telomerase activity.

Pubmed Data : Mol Cell Biochem. 2007 Mar;297(1-2):31-9. Epub 2006 Nov 10. PMID: 17096185
Article Published Date : Mar 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(3785) : AC(1541)
Diseases : Leukemia : CK(718) : AC(263), Promyelocytic leukemia : CK(87) : AC(76)
Pharmacological Actions : Antineoplastic Agents : CK(1055) : AC(505), Apoptotic : CK(2058) : AC(1476), Telomerase Inhibitor : CK(41) : AC(23)

Diosgenin inhibits telomerase activity by down regulation of hTERT gene expression in A549 cell line.

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2013 ;14(11):6945-8. PMID: 24377630
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Diosgenin : CK(2) : AC(1), Fenugreek : CK(102) : AC(31)
Diseases : Lung Cancer : CK(855) : AC(230)
Pharmacological Actions : antioxidant, Antiproliferative : CK(1752) : AC(1193), Chemopreventive : CK(2078) : AC(530), Telomerase Inhibitor : CK(41) : AC(23)
Additional Keywords : Gene Expression Regulation

EGCG fights cancer by modulating telomerase activity.

Pubmed Data : J Ethnopharmacol. 1999 Nov 1;67(2):233-9. PMID: 17570133
Article Published Date : Nov 01, 1999
Study Type : Commentary
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1404) : AC(120)
Diseases : Cancers: All : CK(11833) : AC(3016)
Pharmacological Actions : Telomerase Inhibitor : CK(41) : AC(23)
Additional Keywords : Epigenetic Modification : CK(145) : AC(47)

Ginger exhibits anti-lung cancer properties.

Pubmed Data : J Med Food. 2010 Dec;13(6):1347-54. PMID: 21091248
Article Published Date : Dec 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Catechols : CK(14) : AC(12), Ginger : CK(569) : AC(113)
Diseases : Lung Cancer : CK(855) : AC(230)
Pharmacological Actions : Antiproliferative : CK(1752) : AC(1193), Telomerase Inhibitor : CK(41) : AC(23)
Additional Keywords : Plant Extracts : CK(5359) : AC(1705)

Green Tea induces apoptosis in drug-resistant small-cell lung carcinoma.

Pubmed Data : Biochem Biophys Res Commun. 2007 Aug 17;360(1):233-7. Epub 2007 Jun 14. PMID: 17585882
Article Published Date : Aug 17, 2007
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1404) : AC(120)
Diseases : Carcinoma: Small Cell Lung : CK(2) : AC(2), Lung Cancer : CK(855) : AC(230)
Pharmacological Actions : Apoptotic : CK(2058) : AC(1476), Telomerase Inhibitor : CK(41) : AC(23)
Additional Keywords : Drug Resistant Cancer : CK(9) : AC(9)

Manisa propolis inhibits a T-cell acute lymphoblastic leukemia cell line.

Pubmed Data : Leuk Res. 2005 Nov;29(11):1343-6. PMID: 16055186
Article Published Date : Nov 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Bee Propolis : CK(220) : AC(84)
Diseases : Acute T cell Leukemias : CK(11) : AC(11), Leukemia: T-cell acute Lymphoblastic : CK(35) : AC(13)
Pharmacological Actions : Telomerase Inhibitor : CK(41) : AC(23)

Phyllanthus urinaria induces programmed cell death and reduces telomerase activity in nasopharyngeal cancer cells.

Pubmed Data : Forsch Komplementmed. 2009 Feb;16(1):34-40. Epub 2009 Feb 6. PMID: 19295228
Article Published Date : Feb 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Phyllanthus urinaria : CK(46) : AC(21)
Diseases : Nasopharyngeal Cancer : CK(52) : AC(22)
Pharmacological Actions : Apoptotic : CK(2058) : AC(1476), Telomerase Inhibitor : CK(41) : AC(23)

Prostate cancer involves shortened chromosomal telomeres and excessive telomerase activity. Telomerase inhibitors may have a therapeutic role to play in prostate cancer treatment.

Pubmed Data : Urol Oncol. 2006 Mar-Apr;24(2):122-30. PMID: 16520276
Article Published Date : Mar 01, 2006
Study Type : Review
Additional Links
Diseases : Prostate Cancer : CK(1342) : AC(311)
Pharmacological Actions : Telomerase Inhibitor : CK(41) : AC(23)

Pterostilbene exhibited significant telomerase inhibition in breast and lung cancer cells.

Pubmed Data : Curr Pharm Biotechnol. 2014 ;14(12):1027-35. PMID: 24433502
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Pterostilbene : CK(50) : AC(31)
Diseases : Breast Cancer : CK(2936) : AC(676), Lung Cancer : CK(855) : AC(230)
Pharmacological Actions : Antiproliferative : CK(1752) : AC(1193), Telomerase Inhibitor : CK(41) : AC(23)

Reishi mushroom modulated the miRNA expression in the pathways that regulate telomerase activity in MCF-7 breast cancer cells

Pubmed Data : Int J Med Mushrooms. 2015 ;17(3):231-9. PMID: 25954907
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Reishi Mushroom : CK(112) : AC(46)
Diseases : Breast Cancer : CK(2936) : AC(676)
Pharmacological Actions : MicroRNA modulator : CK(45) : AC(20), Telomerase Inhibitor : CK(41) : AC(23)

Sulforaphane may regress cancerous epigenetic patterns in human bresat cancer cells.

Pubmed Data : Curr Pharm Des. 2010;16(7):884-92. PMID: 20625516
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane : CK(868) : AC(212)
Diseases : Breast Cancer : CK(2936) : AC(676)
Pharmacological Actions : Telomerase Inhibitor : CK(41) : AC(23)
Additional Keywords : Epigenetic Modification : CK(145) : AC(47)

Tabebuia tree bark contains beta-lapachone which inhibits prostate cancer cells via downregulation of cox-2 enzyme, PGE2 and telomerase activity.

Pubmed Data : Pharmacol Res. 2005 Jun;51(6):553-60. PMID: 15829436
Article Published Date : Jun 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Tabebuia : CK(10) : AC(9)
Diseases : Prostate Cancer : CK(1342) : AC(311)
Pharmacological Actions : Cyclooxygenase 2 Inhibitors : CK(311) : AC(174), Prostaglandin Antagonists : CK(27) : AC(13), Telomerase Inhibitor : CK(41) : AC(23)

Telomere lengths remain long (near that of infancy) in the human heart, brain, eyes (retina), testes, and ovaries. Acupuncture and acupressure reduce telomerase activity in tumors and increase telomerase in normal tissue.

Pubmed Data : Chem Pharm Bull (Tokyo). 1991 Jun;39(6):1606-8. PMID: 10193703
Article Published Date : Jun 01, 1991
Study Type : Review
Additional Links
Diseases : Aging : CK(1399) : AC(392)
Therapeutic Actions : Acupressure : CK(261) : AC(26), Acupuncture : CK(1555) : AC(150)
Pharmacological Actions : Telomerase Inhibitor : CK(41) : AC(23), Telomerase Upregulation : CK(101) : AC(27)

Trichosanthes kirilowii extract has antitumor activity in lung cancer cells.

Pubmed Data : Pharm Biol. 2010 Nov;48(11):1302-9. Epub 2010 Aug 25. PMID: 20738166
Article Published Date : Nov 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Trichosanthes Kirilowii : CK(1) : AC(1)
Diseases : Lung Cancer : CK(855) : AC(230)
Pharmacological Actions : Apoptotic : CK(2058) : AC(1476), Telomerase Inhibitor : CK(41) : AC(23)
Additional Keywords : Plant Extracts : CK(5359) : AC(1705)

Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the promyelocytic leukemia cells.

Pubmed Data : Phytomedicine. 2010 Jan;17(1):47-54. Epub 2009 Jul 3. PMID: 19577445
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Chinese Skullcap : CK(99) : AC(59), Wogonin : CK(25) : AC(9)
Diseases : Promyelocytic leukemia : CK(87) : AC(76)
Pharmacological Actions : Apoptotic : CK(2058) : AC(1476), Telomerase Inhibitor : CK(41) : AC(23)

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