Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine)

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View the Evidence: Substances

Antineoplaston A10 and AS2-1 compares favorably to radiation therapy and chemotherapy in patients with recurrent diffuse intrinsic brain stem glioma.

Pubmed Data : Drugs R D. 2003 ;4(2):91-101. PMID: 12718563
Article Published Date : Jan 01, 2003
Study Type : Human Study
Additional Links
Substances : Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine) : CK(92) : AC(1)
Diseases : Glioma: Diffuse Intrinsic Brainstem : CK(10) : AC(1), Glioma: Progressive Brainstem : CK(21) : AC(1)
Pharmacological Actions : Chemopreventive : CK(1528) : AC(382), Chemotherapeutic : CK(40) : AC(8)

Antineoplaston A10 and AS2-1 in children with recurrent and progressive multicentric glioma compares favorably to radiation therapy and chemotherapy.

Pubmed Data : Drugs R D. 2004 ;5(6):315-26. PMID: 15563234
Article Published Date : Jan 01, 2004
Study Type : Human Study
Additional Links
Substances : Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine) : CK(92) : AC(1)
Diseases : Cancers: Pediatric : CK(95) : AC(10), Glioma : CK(74) : AC(40), Glioma: Astrocytic : CK(14) : AC(2), Glioma: Progressive and Recurrent Multicentric : CK(10) : AC(1)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Chemotherapeutic : CK(40) : AC(8)

Antineoplaston A10 and AS2-1 treatment is effective and relatively safe for the long-term survival of high-risk pediatric patients with primitive neuroectodermal tumors.

Pubmed Data : Integr Cancer Ther. 2005 Jun ;4(2):168-77. PMID: 15911929
Article Published Date : Jun 01, 2005
Study Type : Human Study
Additional Links
Substances : Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine) : CK(92) : AC(1)
Diseases : Cancers: Pediatric : CK(95) : AC(10), Primitive Neuroectodermal Tumors (PNETs) : CK(10) : AC(1)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496)

Antineoplaston AS2-1 prolongs the recurrence-free interval between regional treatments and improves survival rate of these patients.

Pubmed Data : Oncol Rep. 2003 Mar-Apr;10(2):391-7. PMID: 12579278
Article Published Date : Mar 01, 2003
Study Type : Human Study
Additional Links
Substances : Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine) : CK(92) : AC(1)
Diseases : Liver Cancer : CK(1641) : AC(266)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Chemopreventive : CK(1528) : AC(382)

Antineoplaston AS2-1 shows promise in the treatment of hormone refractory prostate cancer.

Pubmed Data : Drugs Exp Clin Res. 1990 ;16(7):361-9. PMID: 2152694
Article Published Date : Jan 01, 1990
Study Type : Human Study
Additional Links
Substances : Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine) : CK(92) : AC(1)
Diseases : Prostate Cancer: Hormone Refractory : CK(10) : AC(1)

Antineoplastons A-10 and AS2-1 are less toxic than conventional therapies in cancer patients.

Pubmed Data : Kurume Med J. 1995 ;42(4):241-9. PMID: 8667595
Article Published Date : Jan 01, 1995
Study Type : Human Study
Additional Links
Substances : Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine) : CK(92) : AC(1)

Targeted therapy with antineoplastons A10 and AS2-1 of high-grade, recurrent, and progressive brainstem glioma is an effective treatment (relative to conventional treatment)).

Pubmed Data : Integr Cancer Ther. 2006 Mar ;5(1):40-7. PMID: 16484713
Article Published Date : Mar 01, 2006
Study Type : Human Study
Additional Links
Substances : Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine) : CK(92) : AC(1)
Diseases : Glioma: Progressive Brainstem : CK(21) : AC(1)
Pharmacological Actions : Chemotherapeutic : CK(40) : AC(8)

Case report: antineoplaston AS2-1 for maintenance therapy in liver cancer.

Pubmed Data : Oncol Rep. 1997 Nov-Dec;4(6):1213-6. PMID: 21590224
Article Published Date : Nov 01, 1997
Study Type : Human In Vitro
Additional Links
Substances : Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine) : CK(92) : AC(1)
Diseases : Liver Cancer : CK(1641) : AC(266), Liver Metastasis From Colon Cancer : CK(3) : AC(1)

A quick response of advanced cancer to chemoradiation therapy with antineoplastons has been reported.

Pubmed Data : Oncol Rep. 1998 May-Jun;5(3):597-600. PMID: 9538158
Article Published Date : May 01, 1998
Study Type : Human: Case Report
Additional Links
Substances : Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine) : CK(92) : AC(1)
Diseases : Glioblastoma : CK(46) : AC(20), Lung Cancer : CK(496) : AC(198), Lung Cancer: Metastatic : CK(4) : AC(1)
Pharmacological Actions : Chemotherapeutic : CK(40) : AC(8)

Antineoplaston A10 and AS2-1 has an inhibitory effect on human hepatocellular carcinoma.

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Kurume Med J. 1996 ;43(2):137-47. PMID: 8755117
Article Published Date : Jan 01, 1996
Study Type : Human: Case Report, Review
Additional Links
Substances : Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine) : CK(92) : AC(1)
Diseases : Liver Cancer : CK(1641) : AC(266)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Apoptotic : CK(1489) : AC(1114), Cell Differentiation Inducer : CK(6) : AC(5)

Antineoplaston A2 has anticancer effects.

Pubmed Data : Drugs Exp Clin Res. 1987 ;13 Suppl 1:1-11. PMID: 3569010
Article Published Date : Jan 01, 1987
Study Type : Human: Case Report
Additional Links
Substances : Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine) : CK(92) : AC(1)
Diseases : Bladder Cancer : CK(186) : AC(60), Breast Cancer : CK(2354) : AC(621), Esophageal Cancer : CK(328) : AC(55), Liver Cancer: Metastatic : CK(6) : AC(2), Lung Cancer : CK(496) : AC(198), Mesothelioma : CK(30) : AC(10)
Pharmacological Actions : Anti-metastatic : CK(192) : AC(115), Antineoplastic Agents : CK(877) : AC(496)

Case report: long-term survival following treatment with antineoplastons for colon cancer with unresectable multiple liver metastases.

Pubmed Data : Surg Today. 2003 ;33(6):448-53. PMID: 12768372
Article Published Date : Jan 01, 2003
Study Type : Human: Case Report
Additional Links
Substances : Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine) : CK(92) : AC(1)
Diseases : Colon Cancer : CK(895) : AC(233), Liver Cancer : CK(1641) : AC(266), Liver Cancer: Metastatic : CK(6) : AC(2), Liver Metastasis From Colon Cancer : CK(3) : AC(1)
Pharmacological Actions : Anti-metastatic : CK(192) : AC(115)

Long-term survival and complete response of a patient with recurrent diffuse intrinsic brain stem glioblastoma multiforme has been reported.

Pubmed Data : Integr Cancer Ther. 2004 Sep ;3(3):257-61. PMID: 15312271
Article Published Date : Sep 01, 2004
Study Type : Human: Case Report
Additional Links
Substances : Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine) : CK(92) : AC(1)
Diseases : Glioblastoma : CK(46) : AC(20), Glioblastoma Multiforme : CK(35) : AC(4)
Additional Keywords : Cancer Remission : CK(3) : AC(1)

"Antineoplaston AS2-1 showed an antimetastatic effect against post-operative lung metastases from colon cancer through G1 cell arrest and the subsequent induction of apoptosis."

Pubmed Data : Oncol Rep. 2005 Mar ;13(3):389-95. PMID: 15706406
Article Published Date : Mar 01, 2005
Study Type : Animal Study
Additional Links
Substances : Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine) : CK(92) : AC(1)
Diseases : Cancer Metastasis : CK(272) : AC(135), Colon Cancer : CK(895) : AC(233), Lung Cancer: Metastatic : CK(4) : AC(1), Post-Operative Lung Metastasis of Colon Cancer : CK(2) : AC(1)
Pharmacological Actions : Anti-metastatic : CK(192) : AC(115), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)

"Chronic animal toxicity studies on antineoplaston A2."

Pubmed Data : Drugs Exp Clin Res. 1986 ;12 Suppl 1:73-5. PMID: 3743382
Article Published Date : Jan 01, 1986
Study Type : Animal Study
Additional Links
Substances : Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine) : CK(92) : AC(1)

Antineoplaston AS2-1 may have inhibitory effects against gastrointestinal cancer.

Pubmed Data : Biomed Khim. 2005 ;51(1):48-52. PMID: 15850218
Article Published Date : Jan 01, 2005
Study Type : Animal Study
Additional Links
Substances : Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine) : CK(92) : AC(1)
Diseases : Gastrointestinal Cancer : CK(43) : AC(11)

"Toxicology studies on antineoplaston AS2-1 injections in cancer patients."

Pubmed Data : Drugs Exp Clin Res. 1986 ;12 Suppl 1:25-35. PMID: 3743378
Article Published Date : Jan 01, 1986
Study Type : Review
Additional Links
Substances : Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine) : CK(92) : AC(1)

Antineoplastons: history of the research (I).

Pubmed Data : Drugs Exp Clin Res. 1986 ;12 Suppl 1:1-9. PMID: 3527634
Article Published Date : Jan 01, 1986
Study Type : Review
Additional Links
Substances : Antineoplaston A3 : CK(3) : AC(1), Antineoplaston A5 : CK(3) : AC(1), Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine) : CK(92) : AC(1), Antineoplaston AS2-5 : CK(1) : AC(1), Antineoplastons : CK(134) : AC(36), Urine : CK(5) : AC(3)

Preclinical studies on antineoplaston AS2-1 and antineoplaston AS2-5, degradation products of Antineoplaston A10.

Pubmed Data : Drugs Exp Clin Res. 1986 ;12 Suppl 1:11-6. PMID: 3743376
Article Published Date : Jan 01, 1986
Study Type : Review
Additional Links
Substances : Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine) : CK(92) : AC(1), Antineoplaston AS2-5 : CK(1) : AC(1)

The cellular accumulation of antineoplaston AS21 in human hepatoma cells may drive its anticancer properties.

Pubmed Data : Cancer Lett. 1995 Jan 6 ;88(1):107-12. PMID: 7850766
Article Published Date : Jan 06, 1995
Study Type : In Vitro Study
Additional Links
Substances : Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine) : CK(92) : AC(1)
Diseases : Hepatoma : CK(38) : AC(33), Liver Cancer : CK(1641) : AC(266)
Pharmacological Actions : 1-Glutamine Uptake Inhibitor : CK(2) : AC(2), Antineoplastic Agents : CK(877) : AC(496)

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