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Apigenin

Apigenin

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Article Count - 51
Cumulative Knowledge - 76

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Quick Summary: Current access displays 2 out of 48 associated Diseases

Name	Cumulative Knowledge	Article Count	Focus Articles
Colorectal Cancer	11	2	Log in \| Sign up
Breast Cancer	7	6	Log in \| Sign up

Quick Summary: Current access displays 2 out of 37 associated Pharmacological Actions

Name	Cumulative Knowledge	Article Count	Focus Articles
Antiproliferative	20	17	Log in \| Sign up
Apoptotic	17	14	Log in \| Sign up

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View the Evidence: Substances

A combination of apigenin and EGCG prevent colorectal cancer recurrence.

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Pubmed Data : World J Gastroenterol. 2008 Apr 14;14(14):2187-93. PMID: 18407592

Article Published Date : Apr 14, 2008

Study Type : Human Study

Additional Links

Substances : Apigenin : CK(76) : AC(51), Catechin : CK(403) : AC(130), Flavonoids : CK(909) : AC(289)

Diseases : Colorectal Cancer : CK(877) : AC(321)

Pharmacological Actions : Chemopreventive : CK(1528) : AC(382)

Additional Keywords : Risk Reduction : CK(1909) : AC(196)

Apigenin and quercetin may have a therapeutic role in preventing and treating gastric spasm.

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Pubmed Data : Life Sci. 2009 Jul 3;85(1-2):85-90. Epub 2009 May 8. PMID: 19427869

Article Published Date : Jul 03, 2009

Study Type : Animal Study

Additional Links

Substances : Apigenin : CK(76) : AC(51), Quercetin : CK(318) : AC(136)

Diseases : Gastric Spasm : CK(18) : AC(6)

Pharmacological Actions : Antispasmodic : CK(112) : AC(29), Calcium Channel Blockers : CK(86) : AC(21)

Apigenin demonstrates growth inhibitory activity in cultured breast cells and xenografts, without toxicity.

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Pubmed Data : J Clin Sleep Med. 2009 Aug 15;5(4):377-83. PMID: 18300387

Article Published Date : Aug 15, 2009

Study Type : Animal Study

Additional Links

Substances : Apigenin : CK(76) : AC(51)

Diseases : Breast Cancer : CK(2361) : AC(621)

Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1058) : AC(775), Apoptotic : CK(1535) : AC(1155), Enzyme Inhibitors : CK(372) : AC(208)

Apigenin enhances the anti-tumor effect of gemcitabine.

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Pubmed Data : Cancer Lett. 2008 Jan 18;259(1):39-49. Epub 2007 Oct 29. PMID: 17967505

Article Published Date : Jan 18, 2008

Study Type : Animal Study

Additional Links

Substances : Apigenin : CK(76) : AC(51)

Diseases : Pancreatic Cancer : CK(530) : AC(168)

Pharmacological Actions : Antiproliferative : CK(1058) : AC(775), Apoptotic : CK(1535) : AC(1155), NF-kappaB Inhibitor : CK(595) : AC(401)

Additional Keywords : Drug: Gemcitabine : CK(36) : AC(13), Drug-Plant-Vitamin Synergies : CK(1011) : AC(268)

Apigenin has a protective effect against ovariectomy-induced bone loss in rats.

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Pubmed Data : Life Sci. 2008 Jun 20;82(25-26):1217-23. Epub 2008 Apr 10. PMID: 18508086

Article Published Date : Jun 20, 2008

Study Type : Animal Study

Additional Links

Substances : Apigenin : CK(76) : AC(51)

Diseases : Osteoporosis: Age-Related : CK(14) : AC(6)

Apigenin has a protective role against lipid peroxidation and oxidative stress associated with the development of liver cancer in rats.

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Pubmed Data : Atherosclerosis. 2009 Dec;207(2):420-7. Epub 2009 May 22. PMID: 15185843

Article Published Date : Dec 01, 2009

Study Type : Animal Study

Additional Links

Substances : Apigenin : CK(76) : AC(51), Flavonoids : CK(909) : AC(289)

Diseases : Liver Cancer : CK(1641) : AC(266)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Hepatoprotective : CK(557) : AC(272)

Apigenin is a bioflavonoid that inhibits hypoxia-activated pathways linked to cancer progression in human prostate cancer

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Pubmed Data : Mol Carcinog. 2008 Sep;47(9):686-700. PMID: 18240292

Article Published Date : Sep 01, 2008

Study Type : Animal Study

Additional Links

Substances : Apigenin : CK(76) : AC(51), Flavonoids : CK(909) : AC(289)

Diseases : Hypoxia : CK(100) : AC(41), Prostate Cancer : CK(998) : AC(288)

Pharmacological Actions : Vascular Endothelial Growth Factor A Inhibitor : CK(102) : AC(58)

Apigenin may play an important neuroprotective role in acute transient focal cerebral ischemia-reperfusion injury in rats.

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Pubmed Data : Zhong Yao Cai. 2008 Jun;31(6):870-3. PMID: 18998572

Article Published Date : Jun 01, 2008

Study Type : Animal Study

Additional Links

Substances : Apigenin : CK(76) : AC(51)

Diseases : Cerebral Ischemia : CK(263) : AC(50), Middle Cerebral Artery Occlusion (MCAO) : CK(592) : AC(24)

Pharmacological Actions : Neuroprotective Agents : CK(962) : AC(480)

Apigenin protects against ovalbumin-induced asthma.

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Pubmed Data : Int Immunopharmacol. 2009 Jul;9(7-8):918-24. Epub 2009 Apr 5. PMID: 19345747

Article Published Date : Jul 01, 2009

Study Type : Animal Study

Additional Links

Substances : Apigenin : CK(76) : AC(51)

Diseases : Asthma : CK(918) : AC(134)

Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71)

Apigenin stimulates neurogenesis in adult rats.

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Pubmed Data : Expert Opin Ther Pat. 2009 Apr;19(4):523-7. PMID: 19441930

Article Published Date : Apr 01, 2009

Study Type : Animal Study

Additional Links

Substances : Apigenin : CK(76) : AC(51)

Diseases : Neurodegenerative Diseases : CK(1743) : AC(420), Neurologic Disorders : CK(63) : AC(21)

Pharmacological Actions : Neuritogenic : CK(98) : AC(48)

Apigenin triggers programmed cell death in human prostate cancer.

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Pubmed Data : Carcinogenesis. 2008 Nov;29(11):2210-7. Epub 2008 Aug 25. PMID: 18725386

Article Published Date : Nov 01, 2008

Study Type : Animal Study

Additional Links

Substances : Apigenin : CK(76) : AC(51)

Diseases : Prostate Cancer : CK(998) : AC(288)

Pharmacological Actions : Antiproliferative : CK(1058) : AC(775), Apoptotic : CK(1535) : AC(1155)

Apigenin, a dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation in mice.

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Pubmed Data : Arthritis Res Ther. 2009;11(2):R59. Epub 2009 Apr 30. PMID: 19405952

Article Published Date : Jan 01, 2009

Study Type : Animal Study

Additional Links

Substances : Apigenin : CK(76) : AC(51)

Diseases : Autoimmune Diseases : CK(5317) : AC(779), Lupus Erythematosus: Systemic : CK(949) : AC(53)

Pharmacological Actions : Cyclooxygenase 2 Inhibitors : CK(269) : AC(169), NF-kappaB Inhibitor : CK(595) : AC(401)

Dietary apigenin attenuates the development of atopic dermatitis-like skin lesions in mice.

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Pubmed Data : J Nutr Biochem. 2009 Nov;20(11):876-81. Epub 2008 Nov 6. PMID: 18993046

Article Published Date : Nov 01, 2009

Study Type : Animal Study

Additional Links

Substances : Apigenin : CK(76) : AC(51)

Diseases : Atopic Dermatitis : CK(667) : AC(80)

Olive leaf extract has xanthine-oxidase inhibiting activity which confirms its traditional use for gout.

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Pubmed Data : Phytomedicine. 2011 May 15 ;18(7):561-6. Epub 2010 Dec 8. PMID: 21144719

Article Published Date : May 14, 2011

Study Type : Animal Study

Additional Links

Substances : Apigenin : CK(76) : AC(51), Oleuropein : CK(51) : AC(32), Olive leaf extract : CK(132) : AC(26)

Diseases : Gout : CK(252) : AC(21), Hyperuricemia : CK(253) : AC(32)

Pharmacological Actions : Enzyme Inhibitors : CK(372) : AC(208), Xanthine oxidase inhibitor : CK(25) : AC(11)

Additional Keywords : Drug: Allopurinol : CK(6) : AC(3), Plant Extracts : CK(3616) : AC(1226), Science Confirms Tradition : CK(72) : AC(49)

Quercetin, kaempferol and biapigenin from St. John's wort are neuroprotective against excitotoxicity.

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Pubmed Data : Neurotox Res. 2008 May-Jun;13(3-4):265-79. PMID: 18522906

Article Published Date : May 01, 2008

Study Type : Animal Study

Additional Links

Substances : Apigenin : CK(76) : AC(51), Kaempferol : CK(27) : AC(22), Quercetin : CK(318) : AC(136), St. Johns Wort : CK(186) : AC(46)

Diseases : Excitotoxicity : CK(56) : AC(33)

Pharmacological Actions : Excitatory Amino Acid Agonists : CK(7) : AC(4), Neuroprotective Agents : CK(962) : AC(480)

Apigenin and curcumin effectively inhibit rhabdoid tumor cell growth.

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Pubmed Data : Lipids Health Dis. 2004 Nov 9;3:24. PMID: 20147838

Article Published Date : Nov 09, 2004

Study Type : In Vitro Study

Additional Links

Substances : Apigenin : CK(76) : AC(51), Curcumin : CK(2923) : AC(1482)

Diseases : Rhabdoid Tumor : CK(2) : AC(2)

Pharmacological Actions : Antiproliferative : CK(1058) : AC(775)

Apigenin and luteolin are potent inhibitors of human thyroid cancer cell lines.

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Pubmed Data : Thyroid. 1999 Apr;9(4):369-76. PMID: 10319943

Article Published Date : Apr 01, 1999

Study Type : In Vitro Study

Additional Links

Substances : Apigenin : CK(76) : AC(51), Flavonoids : CK(909) : AC(289), Luteolin : CK(62) : AC(51)

Diseases : Thyroid Cancer : CK(162) : AC(32)

Pharmacological Actions : Antiproliferative : CK(1058) : AC(775)

Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57)

Apigenin and luteolin have anti-inflammatory effects and may have neuroprotective/disease-modifying properties in various neurodegenerative disorders, including Alzheimer's disease (AD).

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Pubmed Data : J Neuroinflammation. 2008;5:41. Epub 2008 Sep 25. PMID: 18817573

Article Published Date : Jan 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Apigenin : CK(76) : AC(51), Luteolin : CK(62) : AC(51)

Diseases : Alzheimer's Disease : CK(886) : AC(160), Brain: Microglial Activation : CK(67) : AC(38), Brain Inflammation : CK(79) : AC(35), Neurodegenerative Diseases : CK(1743) : AC(420)

Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Immunomodulatory : CK(536) : AC(142), Interferon Inducers : CK(31) : AC(9), Neuroprotective Agents : CK(962) : AC(480), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Apigenin combines favorably with the drug 5-Fluorouracil to induce programmed cell death in human breast cancer cells.

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Pubmed Data : Oncol Rep. 2009 Dec;22(6):1533-7. PMID: 19885610

Article Published Date : Dec 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Apigenin : CK(76) : AC(51)

Diseases : Breast Cancer : CK(2361) : AC(621)

Pharmacological Actions : Antiproliferative : CK(1058) : AC(775), Apoptotic : CK(1535) : AC(1155)

Additional Keywords : Drug: 5-flourouracil : CK(88) : AC(22), Drug-Plant-Vitamin Synergies : CK(1011) : AC(268)

Apigenin downregulates the tumor protein production (Geminin) contributing to its activity against pancreatic cancer cell lines.

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Pubmed Data : Mol Carcinog. 2008 Nov;47(11):835-44. PMID: 18404646

Article Published Date : Nov 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Apigenin : CK(76) : AC(51)

Diseases : Pancreatic Cancer : CK(530) : AC(168)

Apigenin induces programmed cell death in fibroblast-like synovial cells associated with the pathophysiology of rheumatoid arthritis.

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Pubmed Data : Chem Biol Interact. 2009 Nov 10;182(1):29-36. Epub 2009 Aug 6. PMID: 19647729

Article Published Date : Nov 10, 2009

Study Type : In Vitro Study

Additional Links

Substances : Apigenin : CK(76) : AC(51), Flavonoids : CK(909) : AC(289)

Diseases : Rheumatoid Arthritis : CK(424) : AC(64)

Pharmacological Actions : Apoptotic : CK(1535) : AC(1155)

Apigenin induces programmed cell death in human breast cancer cells.

Click here to read the entire abstract

Pubmed Data : J Biol Chem. 2004 Feb 6;279(6):4479-89. Epub 2003 Nov 5. PMID: 14602723

Article Published Date : Feb 06, 2004

Study Type : In Vitro Study

Additional Links

Substances : Apigenin : CK(76) : AC(51), Flavonoids : CK(909) : AC(289)

Diseases : Breast Cancer : CK(2361) : AC(621)

Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1058) : AC(775), Apoptotic : CK(1535) : AC(1155), Enzyme Inhibitors : CK(372) : AC(208)

Apigenin induces programmed cell death in primary effusion lymphoma cells.

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Pubmed Data : Cell Prolif. 2010 Jan 14. Epub 2010 Jan 14. PMID: 20074295

Article Published Date : Jan 14, 2010

Study Type : In Vitro Study

Additional Links

Substances : Apigenin : CK(76) : AC(51)

Diseases : Lymphoma : CK(209) : AC(69)

Pharmacological Actions : Apoptotic : CK(1535) : AC(1155)

Apigenin inhibits antiestrogen-resistant breast cancer cell growth.

Click here to read the entire abstract

Pubmed Data : J Pineal Res. 2006 Nov;41(4):358-62. PMID: 18645020

Article Published Date : Nov 01, 2006

Study Type : In Vitro Study

Additional Links

Substances : Apigenin : CK(76) : AC(51)

Diseases : Breast Cancer : CK(2361) : AC(621), Cancers: Drug Resistant : CK(225) : AC(147)

Pharmacological Actions : Antiproliferative : CK(1058) : AC(775), Estrogen Receptor Modulators : CK(28) : AC(19), Selective estrogen enzyme modulator (SEEM) : CK(11) : AC(8)

Additional Keywords : Drug-Plant-Vitamin Synergies : CK(1011) : AC(268)

Apigenin inhibits cell migration in human bladder smooth muscle cells.

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Pubmed Data : Biocell. 2011 Dec ;35(3):71-9. PMID: 22423483

Article Published Date : Dec 01, 2011

Study Type : In Vitro Study

Additional Links

Substances : Apigenin : CK(76) : AC(51)

Diseases : Bladder Cancer : CK(186) : AC(60)

Pharmacological Actions : Mitogen-activated protein kinase inhibitors : CK(11) : AC(2)

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