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Berberine

Berberine

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Article Count - 75
Cumulative Knowledge - 157

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Quick Summary: Current access displays 2 out of 86 associated Diseases

Name	Cumulative Knowledge	Article Count	Focus Articles
Diabetes Mellitus: Type 2	28	7	Log in \| Sign up
Insulin Resistance	23	7	Log in \| Sign up

Quick Summary: Current access displays 2 out of 35 associated Pharmacological Actions

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Hypoglycemic Agents	16	4	Log in \| Sign up
Apoptotic	14	13	Log in \| Sign up

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View the Evidence: Substances

A combination of berberine, red yeast rice and policosanol lowers lipid levels and improves endothelial function and insulin sensitivity in hypercholesterolemic patients.

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Pubmed Data : Nutr Metab Cardiovasc Dis. 2009 Aug 19. Epub 2009 Aug 19. PMID: 19699071

Article Published Date : Aug 19, 2009

Study Type : Human Study

Additional Links

Substances : Berberine : CK(156) : AC(75), Policosanol : CK(184) : AC(22), Red Yeast Rice : CK(164) : AC(25)

Diseases : Endothelial Dysfunction : CK(897) : AC(173), Hypercholesterolemia : CK(1517) : AC(165), Insulin Resistance : CK(1034) : AC(221)

Berberine inhibits acute radiation intestinal syndrome in human with abdomen radiotherapy.

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Pubmed Data : J Forensic Leg Med. 2007 Feb;14(2):87-91. PMID: 19757213

Article Published Date : Feb 01, 2007

Study Type : Human Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Radiation Induced Illness : CK(1018) : AC(249)

Pharmacological Actions : Radioprotective : CK(456) : AC(183)

Anti Therapeutic Actions : Radiotherapy : CK(342) : AC(55)

Berberine is a potent oral hypoglycemic agent with benefical effects on lipid metabolism, comparable in efficacy to metformin.

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Pubmed Data : Metabolism. 2008 May;57(5):712-7. PMID: 18442638

Article Published Date : May 01, 2008

Study Type : Human Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341)

Additional Keywords : Drug: Metformin : CK(195) : AC(23), Metformin Alternatives : CK(19) : AC(6), Natural Substances Versus Drugs : CK(988) : AC(165)

Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression.

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Pubmed Data : Evid Based Complement Alternat Med. 2009 Oct 6; PMID: 19800084

Article Published Date : Oct 06, 2009

Study Type : Human Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341)

Pharmacological Actions : Hypoglycemic Agents : CK(563) : AC(156)

Additional Keywords : Drug: Metformin : CK(195) : AC(23), Drug: Rosiglitazone : CK(17) : AC(5), Insulin Receptor Upregulation : CK(12) : AC(2), Natural Substances Versus Drugs : CK(988) : AC(165)

Hop rho iso-alpha acids, berberine, vitamin D(3) and vitamin K (1) favorably impact biomarkers of bone turnover in postmenopausal women.

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Pubmed Data : J Bone Miner Metab. 2009 Dec 19. Epub 2009 Dec 19. PMID: 20024591

Article Published Date : Dec 19, 2009

Study Type : Human Study

Additional Links

Substances : Berberine : CK(156) : AC(75), Hops : CK(51) : AC(20), Vitamin D : CK(1682) : AC(238), Vitamin K : CK(550) : AC(65)

Diseases : Osteoporosis : CK(1171) : AC(205)

These results suggest that berberine improves insulin sensitivity by inhibiting fat store and adjusting adipokine profile in human preadipocytes and metabolic syndrome patients.

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Pubmed Data : Evid Based Complement Alternat Med. 2012 ;2012:363845. Epub 2012 Mar 8. PMID: 22474499

Article Published Date : Mar 07, 2012

Study Type : Human In Vitro

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Insulin Resistance : CK(1034) : AC(221), Metabolic Syndrome X : CK(645) : AC(122)

Pharmacological Actions : Insulin Sensitizers : CK(167) : AC(36)

Berberine improves neointima formation in a rat model.

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Pubmed Data : Atherosclerosis. 2006 May;186(1):29-37. Epub 2005 Aug 10. PMID:16098530

Article Published Date : May 01, 2006

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Atherosclerosis : CK(523) : AC(77), Intima Media Thickening : CK(1878) : AC(41)

A berberine derivative attenuates cardiac failure.

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Pubmed Data : Acta Pharmacol Sin. 2010 Feb;31(2):165-74. PMID: 20139899

Article Published Date : Feb 01, 2010

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Heart Failure : CK(711) : AC(97), Myocardial Infarction : CK(2632) : AC(117)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

Berbamine induces programmed cell death in human liver cancer cells and inhibits tumor growth in mice.

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Pubmed Data : J Asian Nat Prod Res. 2009;11(3):219-28. PMID: 19408145

Article Published Date : Jan 01, 2009

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Liver Cancer : CK(1641) : AC(266)

Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Tumor Suppressor Protein p53 Upregulation : CK(146) : AC(105)

Berberine (a major constituent of goldenseal) has significant cholesterol-lowering action

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Pubmed Data : Nat Med. 2004 Dec;10(12):1344-51. Epub 2004 Nov 7. PMID: 15531889

Article Published Date : Dec 01, 2004

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Hypercholesterolemia : CK(1517) : AC(165)

Berberine and coptis chinesis (goldenthread) extract prevents neurodegeneration induced by aluminum overload in rats.

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Pubmed Data : Saudi Med J. 2009 Jun;30(6):760-6. PMID: 19526156

Article Published Date : Jun 01, 2009

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75), Goldenthread : CK(7) : AC(5)

Diseases : Aluminum Toxicity : CK(100) : AC(36)

Berberine attenuates experimental autoimmune encephalomyelitis in mice.

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Pubmed Data : PLoS One. 2010;5(10):e13489. Epub 2010 Oct 19. PMID: 20976070

Article Published Date : Jan 01, 2010

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Blood-Brain-Barrier Disorders : CK(25) : AC(15), Brain Inflammation : CK(79) : AC(35), Multiple Sclerosis : CK(716) : AC(133)

Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(49) : AC(30)

Berberine can ameliorate pro-inflammatory cytokines induced intestinal permeability in vitro,

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Pubmed Data : Eur J Pharm Sci. 2010 Feb 8. Epub 2010 Feb 8. PMID: 20149867

Article Published Date : Feb 08, 2010

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Intestinal Permeability : CK(224) : AC(53)

Berberine can prevent fructose-induced insulin resistance in rats

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Pubmed Data : Toxicol Appl Pharmacol. 2006 Oct 1;216(1):11-9. Epub 2006 May 17. PMID: 18563319

Article Published Date : Oct 01, 2006

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Fructose-Induced Toxicity : CK(138) : AC(49), Insulin Resistance : CK(1034) : AC(221), Liver Stress: Fructose-Induced : CK(19) : AC(10)

Berberine exhibits neuroprotective qualities against ischemic brain damage in stroke models

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Pubmed Data : Neurosci Lett. 2008 Dec 5 ;447(1):31-6. Epub 2008 Sep 30. PMID: 18838103

Article Published Date : Dec 05, 2008

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Brain Ischemia : CK(94) : AC(38), Hypoxia : CK(100) : AC(41), Middle Cerebral Artery Occlusion (MCAO) : CK(592) : AC(24)

Pharmacological Actions : Neuroprotective Agents : CK(962) : AC(480)

Additional Keywords : Ischemia Reperfusion Injury

Berberine has a preventive effect on experimental colon cancer.

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Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2010 Oct;35(20):2768-73. PMID: 21246838

Article Published Date : Oct 01, 2010

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Colon Cancer : CK(895) : AC(233)

Pharmacological Actions : Chemopreventive : CK(1528) : AC(382), Cyclooxygenase 2 Inhibitors : CK(269) : AC(169)

Berberine has anticonvulsant activity in mice.

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Pubmed Data : Epilepsy Behav. 2010 Jul;18(3):207-10. PMID: 20638957

Article Published Date : Jul 01, 2010

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Convulsions : CK(10) : AC(5), Seizures : CK(122) : AC(28)

Pharmacological Actions : Anticonvulsants : CK(113) : AC(29)

Berberine has protective effect for diabetes through increasing insulin expression, beta cell regeneration, antioxidant enzyme activity and decreasing lipid peroxidation.

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Pubmed Data : Eur J Pharmacol. 2009 Mar 15;606(1-3):262-8. Epub 2009 Jan 19. PMID: 19374872

Article Published Date : Mar 15, 2009

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Diabetes Mellitus: Type 1 : CK(1107) : AC(218)

Additional Keywords : Beta Cell Regeneration : CK(60) : AC(24)

Berberine improves free-fatty-acid-induced insulin resistance.

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Pubmed Data : Metabolism. 2009 Dec;58(12):1694-702. Epub 2009 Sep 19. PMID: 19767038

Article Published Date : Dec 01, 2009

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Insulin Resistance : CK(1034) : AC(221)

Pharmacological Actions : Hypoglycemic Agents : CK(563) : AC(156)

Berberine inhibits adipogenesis in high-fat diet-induced obesity mice.

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Pubmed Data : Fitoterapia. 2009 Oct 25. Epub 2009 Oct 25. PMID: 19861153

Article Published Date : Oct 25, 2009

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Obesity : CK(1849) : AC(275)

Pharmacological Actions : Anti-Adipogenic : CK(87) : AC(44)

Berberine inhibits human tongue cancer growth in an animal xenograft model.

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Pubmed Data : Phytomedicine. 2009 Mar 19. PMID: 19303753

Article Published Date : Mar 19, 2009

Study Type : Transgenic Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Tongue Cancer : CK(14) : AC(10)

Berberine is a key component in Coptis chinensis with anti-plague activity.

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Pubmed Data : Planta Med. 2009 Mar;75(4):396-8. Epub 2008 Dec 3. PMID: 19053015

Article Published Date : Mar 01, 2009

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75), Coptis chinensis : CK(4) : AC(3)

Diseases : Bubonic Plague : CK(2) : AC(1)

Pharmacological Actions : Anti-Bacterial Agents : CK(970) : AC(316)

Berberine may have therapeutic value in those with high homocysteine by regulating liver cholesterol synthesis.

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Pubmed Data : Am J Physiol Regul Integr Comp Physiol. 2010 Dec 22. Epub 2010 Dec 22. PMID: 21178122

Article Published Date : Dec 22, 2010

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : High Cholesterol : CK(1718) : AC(198), High Homocysteine : CK(368) : AC(57)

Berberine modulates GLP-1 via promoting GLP-1 secretion and GLP-1 biosynthesis.

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Pubmed Data : J Altern Complement Med. 1995 Winter;1(4):361-9. PMID: 19945441

Article Published Date : Dec 01, 1995

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Pharmacological Actions : Glucagon Like peptide 1 (GLP-1) Up-regulation : CK(118) : AC(30)

Berberine prevents the progression of type 1 diabetes in mice through decreased Th17 and Th1 cytokine secretion.

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Pubmed Data : J Biol Chem. 2009 Oct 9;284(41):28420-9. Epub 2009 Aug 6. PMID: 19661066

Article Published Date : Oct 09, 2009

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Autoimmune Diseases : CK(5317) : AC(779), Immune Dysregulation: TH17 over-expression : CK(2) : AC(1), Immune Dysregulation: TH1 dominance : CK(27) : AC(6)

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