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Berberine

Berberine

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Article Count - 75
Cumulative Knowledge - 157

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Quick Summary: Current access displays 2 out of 86 associated Diseases

Name	Cumulative Knowledge	Article Count	Focus Articles
Diabetes Mellitus: Type 2	28	7	Log in \| Sign up
Insulin Resistance	23	7	Log in \| Sign up

Quick Summary: Current access displays 2 out of 35 associated Pharmacological Actions

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View the Evidence: Substances

Berberine promotes glucagon-like peptide-1 (7-36) amide secretion in streptozotocin-induced diabetic rats.

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Pubmed Data : J Endocrinol. 2009 Feb;200(2):159-65. Epub 2008 Nov 7. PMID: 18996945

Article Published Date : Feb 01, 2009

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341)

Pharmacological Actions : Glucagon Like peptide 1 (GLP-1) Up-regulation : CK(118) : AC(30), Hypoglycemic Agents : CK(563) : AC(156)

Berberine promotes neurite extension and axonal regeneration in injured nerves of the peripheral nervous system

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Pubmed Data : J Med Food. 2012 Apr ;15(4):413-7. Epub 2012 Feb 8. PMID: 22316297

Article Published Date : Apr 01, 2012

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75), Goldenthread : CK(7) : AC(5)

Diseases : Demyelinating Diseases : CK(1278) : AC(250), Peripheral Nerve Diseases : CK(53) : AC(6), Peripheral Neuropathies : CK(394) : AC(31)

Pharmacological Actions : Neuritogenic : CK(98) : AC(48)

Additional Keywords : Nerve Regeneration : CK(26) : AC(9), Remyelination : CK(15) : AC(10), Sciatic Nerve : CK(4) : AC(2)

Berberine protects against fructose-and-salt induced hypertensive renal injury.

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Pubmed Data : Zhong Yao Cai. 2011 Mar ;34(3):412-5. PMID: 21823461

Article Published Date : Mar 01, 2011

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Fructose-Induced Toxicity : CK(138) : AC(49), Hypertension: Renal : CK(2) : AC(1), Kidney Diseases : CK(424) : AC(71)

Pharmacological Actions : Renoprotective : CK(191) : AC(90)

Problem Substances : Fructose : CK(356) : AC(103), Sodium Chloride : CK(14) : AC(3)

Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

Berberine protects against the hepatic damage induced by Paracetamol

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Pubmed Data : Fitoterapia. 2000 Feb ;71(1):25-33. PMID: 11449466

Article Published Date : Feb 01, 2000

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(100) : AC(26), Chemically-Induced Liver Damage : CK(475) : AC(175)

Pharmacological Actions : Hepatoprotective : CK(557) : AC(272)

Problem Substances : Paracetamol : CK(44) : AC(6)

Berberine reduces insulin resistance through upregulation of insulin receptor expression.

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Pubmed Data : Metabolism. 2009 Jan;58(1):109-19. PMID: 19059538

Article Published Date : Jan 01, 2009

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Insulin Resistance : CK(1034) : AC(221)

Pharmacological Actions : Hypoglycemic Agents : CK(563) : AC(156)

Additional Keywords : Insulin Receptor Upregulation : CK(12) : AC(2)

Berberine reduces thyroxine-induced diarrhea in rats.

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Pubmed Data : J Korean Med Sci. 2001 Dec;16 Suppl:S42-53. PMID: 19323986

Article Published Date : Dec 01, 2001

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Diarrhea: Drug-Associated : CK(22) : AC(2), Drug-Induced Toxicity: L-Thyroxine : CK(23) : AC(8)

Pharmacological Actions : Antidiarrheals : CK(48) : AC(9)

Cinnamaldehyde and berberine have greater anti-diabetic efficacy than metformin.

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Pubmed Data : Chin Med J (Engl). 2008 Nov 5;121(21):2124-8. PMID: 19080170

Article Published Date : Nov 05, 2008

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75), Cinnamaldehyde : CK(170) : AC(17), Cinnamon : CK(135) : AC(61)

Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341)

Additional Keywords : Drug: Metformin : CK(195) : AC(23), Metformin Alternatives : CK(19) : AC(6), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Coptidis rhizoma and Berberine inhibit the behavioral effects of cocaine.

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Pubmed Data : Phytother Res. 2000 Sep;14(6):428-31. PMID: 18955248

Article Published Date : Sep 01, 2000

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75), Coptidis rhizoma : CK(6) : AC(4)

Diseases : Cocaine Withdrawal : CK(26) : AC(7)

Coptidis Rhizoma attenuates repeated nicotine-induced behavioural sensitization in the rat.

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Pubmed Data : J Pharm Pharmacol. 2007 Dec;59(12):1663-9. PMID: 18053328

Article Published Date : Dec 01, 2007

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75), Coptidis rhizoma : CK(6) : AC(4)

Diseases : Smoking Cessation: Nicotine Addiction : CK(111) : AC(16)

Our results indicate that berberine can be a potential chemoprevention and chemotherapy agent for human colon cancer by targeting Wnt/β-catenin signaling.

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Pubmed Data : Int J Oncol. 2012 Apr 2. Epub 2012 Apr 2. PMID: 22469784

Article Published Date : Apr 01, 2012

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Colon Cancer : CK(895) : AC(233)

Pharmacological Actions : Wnt/β-catenin pathway down-regulation : CK(6) : AC(3)

Panax ginseng combined with berberine has a positive effect in experimental rats with chronic congestive heart failure.

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Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2009 Feb;34(3):324-7. PMID: 19445159

Article Published Date : Feb 01, 2009

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75), Panax Ginseng : CK(49) : AC(21)

Diseases : Congestive Heart Failure : CK(256) : AC(33), Heart Failure : CK(711) : AC(97)

Sustained antidiabetic effects of a berberine-containing chinese herbal medicine through regulation of hepatic gene expression.

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Pubmed Data : Diabetes. 2012 Apr ;61(4):933-43. Epub 2012 Mar 6. PMID: 22396199

Article Published Date : Mar 05, 2012

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Diabesity : CK(2) : AC(1)

"Antibacterial and synergy of berberines with antibacterial agents against clinical multi-drug resistant isolates of methicillin-resistant Staphylococcus aureus (MRSA)."

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Pubmed Data : Molecules. 2012 ;17(9):10322-30. Epub 2012 Aug 29. PMID: 22932213

Article Published Date : Dec 31, 2011

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Staphylococcus aureus: Methicillin-resistant (MRSA) : CK(191) : AC(27)

Pharmacological Actions : Anti-Bacterial Agents : CK(970) : AC(316)

Additional Keywords : Natural Substance/Drug Synergy : CK(5) : AC(1)

Barberry, Goldenseal, Oregan grape and Goldenthread contains berberine, a powerful antimicrobial.

Click here to read the entire abstract

Pubmed Data : 1: Altern Med Rev. 2000 Apr;5(2):175-7. PMID: 12203264

Article Published Date : Apr 01, 2000

Study Type : In Vitro Study

Additional Links

Substances : Barberry : CK(5) : AC(4), Berberine : CK(156) : AC(75), Goldenseal : CK(6) : AC(6), Goldenthread : CK(7) : AC(5), Oregon Grape : CK(1) : AC(4)

Diseases : Bacterial Infections and Mycoses : CK(127) : AC(51)

Berberine ameloriates diabetic microendothelial injury associated with high blood sugar and glycation.

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Pubmed Data : Eur J Pharmacol. 2011 Jan 13. Epub 2011 Jan 13. PMID: 21236251

Article Published Date : Jan 13, 2011

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Advanced Glycation End products (AGE) : CK(2114) : AC(40), Diabetes: Glycation/A1C : CK(186) : AC(33), Diabetes Mellitus: Type 2 : CK(3429) : AC(341)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

Berberine and a Barberry (Berberis lycium) extract inhibit human promyelocytic leukemia proliferation.

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Pubmed Data : Wien Med Wochenschr. 1997;147(14):323-7. PMID: 19909759

Article Published Date : Jan 01, 1997

Study Type : In Vitro Study

Additional Links

Substances : Barberry : CK(5) : AC(4), Berberine : CK(156) : AC(75)

Diseases : Promyelocytic leukemia : CK(136) : AC(74)

Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114)

Berberine and coptis chinesis have inhibitory effect against Microcystis aeruginosa.

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Pubmed Data : Water Sci Technol. 2010;61(3):763-9. PMID: 20150713

Article Published Date : Jan 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75), Coptis chinensis : CK(4) : AC(3)

Diseases : Microcystis aeruginosa : CK(2) : AC(2)

Berberine and evodiamine inhibit human white preadipocyte differentiation, indicating their potential use as anti-obesity agents.

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Pubmed Data : J Eur Acad Dermatol Venereol. 2004 Nov;18(6):649-53. PMID: 19799972

Article Published Date : Nov 01, 2004

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75), Evodiamine : CK(1) : AC(1)

Diseases : Obesity : CK(1849) : AC(275)

Pharmacological Actions : Anti-Adipogenic : CK(87) : AC(44)

Berberine and puerarin lower the degree of insulin resistance and the androgen synthesis in procine ovarian thecal cells, indicating their potential value in the treatment of polycystic syndrome.

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Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Jul;29(7):623-7. PMID: 19852296

Article Published Date : Jul 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75), Puerarin : CK(14) : AC(7)

Diseases : Insulin Resistance : CK(1034) : AC(221), Polycystic Ovary Syndrome : CK(309) : AC(29)

Berberine causes a dose-dependent reduction in breast cancer cell proliferation.

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Pubmed Data : Planta Med. 2008 Nov;74(14):1693-700. Epub 2008 Oct 24. PMID: 18951337

Article Published Date : Nov 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Breast Cancer : CK(2354) : AC(621)

Berberine chloride causes programmed cell death in Leishmania donovani promastigotes.

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Pubmed Data : Free Radic Res. 2009 Aug 7:1-10. Epub 2009 Aug 7. PMID: 19669998

Article Published Date : Aug 07, 2009

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Leishmaniasis : CK(20) : AC(17)

Pharmacological Actions : Apoptotic : CK(1489) : AC(1114)

Berberine could reduce epithelial gut permeability, and might help explain the possible mechanisms of anti-diarrhea activity of berberine.

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Pubmed Data : Fitoterapia. 2009 Jun;80(4):241-8. Epub 2009 Feb 23. PMID: 19243699

Article Published Date : Jun 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Diarrhea : CK(544) : AC(72), Leaky Gut Syndrome : CK(224) : AC(53)

Berberine exerts anti-adipogenic activity.

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Pubmed Data : Biochem Biophys Res Commun. 2011 Aug 27. Epub 2011 Aug 27. PMID: 21893041

Article Published Date : Aug 27, 2011

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Pharmacological Actions : Anti-Adipogenic : CK(87) : AC(44)

Berberine exhibits preferential selectivity toward pancreatic cancer cells compared to normal ones.

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Pubmed Data : Planta Med. 2010 May 7. Epub 2010 May 7. PMID: 20455200

Article Published Date : May 07, 2010

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Pancreatic Cancer : CK(530) : AC(168)

Additional Keywords : Selective Cytotoxicity : CK(58) : AC(41)

Berberine has a number of anticancer properties.

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Pubmed Data : Anticancer Drugs. 2009 Oct;20(9):757-69. PMID: 19704371

Article Published Date : Oct 01, 2009

Study Type : Review

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Cancers: All : CK(9062) : AC(2869)

Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114)

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