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Berberine

Berberine

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Article Count - 75
Cumulative Knowledge - 157

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Quick Summary: Current access displays 2 out of 86 associated Diseases

Name	Cumulative Knowledge	Article Count	Focus Articles
Diabetes Mellitus: Type 2	28	7	Log in \| Sign up
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View the Evidence: Substances

Berberine has an inhibitory effect against Streptococcus pyogenes.

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Pubmed Data : Antimicrob Agents Chemother. 1988 Sep;32(9):1370-4. PMID: 3058020

Article Published Date : Sep 01, 1988

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Lipopolysaccharide-Induced Toxicity : CK(227) : AC(128), Streptococcus pyogenes : CK(18) : AC(16)

Berberine has cardiovascular effects which may benefit arrhythmias and/or heart failure.

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Pubmed Data : Cardiovasc Drug Rev. 2001 Fall;19(3):234-44. PMID: 11607041

Article Published Date : Sep 01, 2001

Study Type : Commentary

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Cardiac Arrhythmias : CK(461) : AC(65), Heart Failure : CK(711) : AC(97)

Berberine increases platelet count in patients with primary and secondary thrombocytopenia.

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Pubmed Data : Gematol Transfuziol. 1994 Sep-Oct;39(5):33-5. PMID: 7896030

Article Published Date : Sep 01, 1994

Study Type : Review

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Thrombocytopenia : CK(800) : AC(25)

Berberine induces cell cycle arrest and programmed cell death in human glioblastoma cells.

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Pubmed Data : Biol Pharm Bull. 2008 Apr;31(4):558-62. PMID: 18379040

Article Published Date : Apr 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Glioblastoma : CK(46) : AC(20)

Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)

Berberine induces cell cycle arrest and programmed cell death in human osteosarcoma cells.

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Pubmed Data : Mutat Res. 2009 Mar 9;662(1-2):75-83. Epub 2008 Dec 31. PMID: 19159633

Article Published Date : Mar 09, 2009

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Osteosarcoma : CK(80) : AC(39)

Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319), Tumor Suppressor Protein p53 Upregulation : CK(146) : AC(105)

Berberine induces cell cycle arrest and programmed cell death in human prostate cancer cells.

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Pubmed Data : Mol Cancer Ther. 2006 Feb;5(2):296-308. PMID: 16505103

Article Published Date : Feb 01, 2006

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Prostate Cancer : CK(998) : AC(288)

Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)

Additional Keywords : Selective Cytotoxicity : CK(58) : AC(41)

Berberine induces cell death in human glioblastoma cells

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Pubmed Data : Biol Pharm Bull. 2010 ;33(10):1644-9. PMID: 20930370

Article Published Date : Jan 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Glioblastoma : CK(46) : AC(20), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Apoptotic : CK(1489) : AC(1114), Bcl-2 protein down-regulation : CK(49) : AC(38)

Additional Keywords : Phytotherapy : CK(177) : AC(27), Plant Extracts : CK(3572) : AC(1216)

Berberine induces dendritic cell apoptosis and has therapeutic potential for rheumatoid arthritis.

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Pubmed Data : Arthritis Rheum. 2010 Dec 15. Epub 2010 Dec 15. PMID: 21162100

Article Published Date : Dec 15, 2010

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Rheumatoid Arthritis : CK(424) : AC(64)

Pharmacological Actions : Apoptotic : CK(1489) : AC(1114)

Berberine inhibits cell migration at low dosese and induces cell cycle arrest and programmed cell death at high dosease in nasopharyngeal cancer cells.

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Pubmed Data : Int J Mol Med. 2009 Jul;24(1):131-8. PMID: 19513545

Article Published Date : Jul 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Cancer Metastasis : CK(272) : AC(135), Nasopharyngeal Cancer : CK(58) : AC(21)

Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Berberine inhibits growth, induces G1 arrest and apoptosis in human epidermoid carcinoma.

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Pubmed Data : Carcinogenesis. 2006 Oct;27(10):2018-27. Epub 2006 Apr 18. PMID: 16621886

Article Published Date : Oct 01, 2006

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Skin Cancer: Squamous Cell : CK(52) : AC(16)

Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)

Berberine inhibits hepatic stellate cell proliferation and prevents experimental liver fibrosis.

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Pubmed Data : Biol Pharm Bull. 2009 Sep;32(9):1533-7. PMID: 19721228

Article Published Date : Sep 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Liver Fibrosis : CK(341) : AC(74)

Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Cell cycle arrest : CK(390) : AC(319)

Berberine inhibits human neuroblastoma cell growth through induction of programmed cell death.

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Pubmed Data : Anticancer Res. 2008 Nov-Dec;28(6A):3777-84. PMID: 19189664

Article Published Date : Nov 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Neuroblastoma : CK(52) : AC(31)

Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319), Tumor Suppressor Protein p53 Upregulation : CK(146) : AC(105)

Berberine inhibits pulmonary metastasis of metastatic melanoma cells.

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Pubmed Data : Phytother Res. 2011 Sep 26. Epub 2011 Sep 26. PMID: 21953764

Article Published Date : Sep 26, 2011

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Cancer Metastasis : CK(272) : AC(135), Melanoma : CK(171) : AC(87)

Berberine inhibits the expression and secretion of tumor necrosis factor alpha.

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Pubmed Data : Endocrine. 2008 Jun;33(3):331-7. PMID: 19034703

Article Published Date : Jun 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Pharmacological Actions : Interleukin-6 Downregulation : CK(470) : AC(135), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Berberine inhibits the growth of anoikis-resistant breast cancer cell lines.

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Pubmed Data : Phytomedicine. 2009 Oct 1. Epub 2009 Oct 1. PMID: 19800775

Article Published Date : Oct 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Breast Cancer : CK(2354) : AC(621)

Berberine may overcome insulin resistance via modulating key molecules in insulin signaling pathway, leading to increased glucose uptake in insulin-resistant cells.

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Pubmed Data : Mol Cell Endocrinol. 2010 Apr 12;317(1-2):148-53. Epub 2009 Dec 29. PMID: 20036710

Article Published Date : Apr 12, 2010

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Insulin Resistance : CK(1034) : AC(221)

Berberine prevents HIV protease inhibitor-induced inflammation.

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Pubmed Data : PLoS One. 2010;5(2):e9069. Epub 2010 Feb 9. PMID: 20161729

Article Published Date : Jan 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : HIV Drug-Induced Toxicity : CK(68) : AC(13), HIV Infections : CK(577) : AC(184), Inflammation : CK(1077) : AC(363)

Pharmacological Actions : HIV Protease Inhibitors : CK(26) : AC(15), Interleukin-6 Downregulation : CK(470) : AC(135), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of adipocyte.

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Pubmed Data : Exp Mol Med. 2006 Dec 31;38(6):599-605. PMID: 17202835

Article Published Date : Dec 31, 2006

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Inflammation : CK(1077) : AC(363), Obesity : CK(1849) : AC(275), Overweight : CK(2176) : AC(342)

Pharmacological Actions : Anti-Adipogenic : CK(87) : AC(44)

Berberine, a compound found within plants such as goldenseal, inhibit the growth of melanoma cell lines.

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Pubmed Data : Cancer Chemother Pharmacol. 2008 May;61(6):1007-18. Epub 2007 Jul 28. PMID: 17661039

Article Published Date : May 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75), Goldenseal : CK(6) : AC(6)

Diseases : Malignant Melanoma : CK(189) : AC(8), Melanoma : CK(171) : AC(87)

Pharmacological Actions : Anti-Proliferative : CK(55) : AC(49)

Berberine, curcumin and hesperidin can increase mucin release by directly acting on airway mucin-secreting cells and suggest that these agents be further studied for possible use as mild expectorants during the treatment of chronic airway diseases.

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Pubmed Data : Rev Neurol. 2001 Dec 1-15;33(11):1010-4. PMID: 12865970

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75), Curcumin : CK(2910) : AC(1482), Flavonoids : CK(909) : AC(289), Hesperidin : CK(160) : AC(38)

Diseases : Allergic Airway Diseases : CK(41) : AC(17)

Pharmacological Actions : Expectorants : CK(1) : AC(1)

Curcumin has chemosensitizing activity in multidrug resistant tumor cell lines.

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Pubmed Data : Zhong Yao Cai. 2001 Sep;24(9):655-7. PMID: 11799777

Article Published Date : Sep 01, 2001

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75), Curcumin : CK(2910) : AC(1482)

Diseases : Cancers: Drug Resistant : CK(225) : AC(147), Cancers: Multi-Drug Resistant : CK(92) : AC(73)

Pharmacological Actions : Chemosensitizer : CK(197) : AC(159)

Additional Keywords : Drug Synergy : CK(327) : AC(147)

Curcumin inhibits the formation of capillary-like tubes by rat lymphatic endothelial cells.

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Pubmed Data : Cancer Lett. 2007 Jun 28;251(2):288-95. Epub 2007 Jan 2. PMID: 17197075

Article Published Date : Jun 28, 2007

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75), Curcumin : CK(2910) : AC(1482)

Diseases : Cancer Metastasis : CK(272) : AC(135), Lymphangioendothelioma : CK(1) : AC(1)

Pharmacological Actions : Anti-metastatic : CK(192) : AC(115), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71)

Goldenthread (C. chinensis) inhibits liver cancer cell growth.

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Pubmed Data : Int J Mol Med. 2009 Oct;24(4):571-7. PMID: 19724899

Article Published Date : Oct 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75), Goldenthread : CK(7) : AC(5)

Diseases : Liver Cancer : CK(1641) : AC(266)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Antiproliferative : CK(1052) : AC(775), Cell cycle arrest : CK(390) : AC(319)

Polyphenols may have therapeutic value in a variety of diseases through modulating AMP-activated protein kinase which reduce fatty acid and cholesterol synthesis and gluconeogenesis.

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Pubmed Data : N Biotechnol.2009 Oct 1;26(1-2):17-22. Epub 2009 Apr 2. PMID: 19818314

Article Published Date : Oct 01, 2009

Study Type : Commentary

Additional Links

Substances : Berberine : CK(156) : AC(75), EGCG (Epigallocatechin gallate) : CK(859) : AC(109), Polyphenols : CK(427) : AC(174), Quercetin : CK(318) : AC(136), Resveratrol : CK(977) : AC(590)

Diseases : Diabetes Mellitus: Type 1 : CK(1107) : AC(218), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Hypertension : CK(2783) : AC(271), Metabolic Syndrome X : CK(645) : AC(122), Obesity : CK(1849) : AC(275)

Pharmacological Actions : AMP-activated protein kinase modulation : CK(2) : AC(2), Gluconeogenesis Inhibitor : CK(20) : AC(14)

Resveratrol, EGCG, berberine and alpha-lipoic acid may have a beneficial effect on bone health through negatively regulating RANKL.

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Pubmed Data : Bone. 2010 Nov;47(5):926-37. Epub 2010 Aug 7. PMID: 20696287

Article Published Date : Nov 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Alpha-Lipoic Acid : CK(384) : AC(82), Berberine : CK(156) : AC(75), Catechin : CK(403) : AC(130), Resveratrol : CK(977) : AC(590)

Diseases : Osteoporosis : CK(1171) : AC(205)

Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Osteogenic : CK(2) : AC(2), RANK Downregulation : CK(1) : AC(1)

Additional Keywords : Drug: Metformin : CK(195) : AC(23), Macrophage Colony-Stimulating Factor : CK(3) : AC(2), Stilbenes : CK(402) : AC(242)

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