Berberine

Name	AC	CK
Insulin Resistance	23	92
Obesity	24	89
Diabetes Mellitus: Type 2	33	77
Inflammation	24	71
Hyperlipidemia	14	58
Dyslipidemias	3	41
C-Reactive Protein	2	40
Polycystic Ovary Syndrome	9	40
Breast Cancer	19	39
Cancers: All	18	38
Alzheimer's Disease	25	37
Helicobacter Pylori Infection	6	37
Lung Cancer	10	33
Nonalcoholic fatty liver disease (NAFLD)	17	31
Liver Cancer	20	25
Colorectal Cancer	10	24
Diabetic Complications	8	24
High Cholesterol	2	22
Hypercholesterolemia	3	22
Triglycerides: Elevated	2	22
Lipopolysaccharide-Induced Toxicity	14	21
Myocardial Ischemia	7	20
Colon Cancer	13	18
Osteoporosis	6	18
Rheumatoid Arthritis	8	18
Metabolic Diseases	6	17
Colitis	8	15
Diabetic Nephropathy	7	14
Atherosclerosis	8	13
Breast Cancer: Triple Negative	11	13
Cerebral Ischemia	7	13
High Fat Diet	7	13
Hyperglycemia	8	13
Ulcerative Colitis	8	13
Brain Inflammation	6	12
Depression	6	12
Endothelial Dysfunction	2	12
Fatty Liver	2	12
Kidney Diseases	2	12
Oxidative Stress	8	12
Diarrhea	2	11
Gastric Cancer	9	11
Glioblastoma	8	11
Atrial Fibrillation	1	10
Bacterial Vaginosis	1	10
Cognitive Decline/Dysfunction	5	10
Gastrointestinal Diseases	1	10
Osteosarcoma	5	10
Pancreatitis	6	10
Radiation Induced Illness	1	10
Sepsis	5	9
Cancers: Drug Resistant	7	8
Chemically-Induced Liver Damage	4	8
Heart Failure	5	8
Hypertension	5	8
Ischemia	5	8
Metabolic Syndrome X	4	8
Arthritis	4	7
Diabetes Mellitus: Type 1	4	7
Diabetes: Cognitive Dysfunction	4	7
Diabetic Neuropathy	4	7
Neurodegenerative Diseases	6	7
Carcinoma: Non-Small-Cell Lung	5	6
Cardiomyopathy	3	6
Cardiovascular Diseases	5	6
Epilepsy	3	6
Hypoxia	4	6
Melanoma	6	6
Ovarian Cancer	6	6
Autoimmune Diseases	3	5
Candida Albicans	5	5
Cervical Cancer	5	5
Chemotherapy-Induced Toxicity: Doxorubicin	3	5
Glioma	4	5
Influenza	3	5
Peripheral Neuropathies	3	5
Psoriasis	1	5
Acetaminophen (Tylenol) Toxicity	2	4
Advanced Glycation End products (AGE)	3	4
Alcohol Toxicity	2	4
Allergic Rhinitis	2	4
Asthma	3	4
Chemotherapy-Induced Toxicity: Paclitaxel	2	4
Chikungunya Virus	3	4
Enterocolitis: Necrotiziing	2	4
Fibrosis	2	4
Fructose-Induced Toxicity	2	4
Gastritis	2	4
Kidney Damage: Drug-Induced	2	4
Myocardial Infarction	2	4
Nasopharyngeal Cancer	3	4
Periodontitis	2	4
Prostatic Hyperplasia: Benign	2	4
Pseudomonas aeruginosa	3	4
Traumatic Brain Injury	2	4
Acute T cell Leukemias	3	3
Brain Ischemia	2	3
Brain: Oxidative Stress	2	3
Cancer Metastasis	3	3
Coxsackievirus Infections	2	3
Dementia	2	3
Diabetes: Oxidative Stress	2	3
Diabetic Retinopathy	3	3
Endometrial Cancer	2	3
Escherichia coli Infections	2	3
Hepatic Steatosis	2	3
Hydrogen Peroxide Induced Toxicity	3	3
Hypoglycemia	2	3
Leishmaniasis	2	3
Liver Fibrosis	2	3
Spinal Cord Injuries	2	3
Uveitis	2	3
Acute Respiratory Distress Syndrome	1	2
Adenomyosis	2	2
Aging	1	2
Aging: Brain	1	2
Alcoholic Liver Disease	1	2
Aluminum Toxicity	1	2
Aneurysm: Cerebral	1	2
Anxiety	1	2
Arsenic Poisoning	1	2
Arterial Hardening: Elasticity	1	2
Atopic Dermatitis	1	2
Autism	1	2
Bladder Dysfunction	1	2
Blood-Brain-Barrier Disorders	1	2
Bone Diseases	1	2
Brain Injury: Traumatic	1	2
Breast Cancer: Chemically-Induced	1	2
Bubonic Plague	1	2
Candida Infection	2	2
Cardiac Hypertrophy	1	2
Chemotherapy-Induced Toxicity: 5-fluorouracil	1	2
Chronic Myeloid Leukemia	1	2
Cocaine Withdrawal	1	2
Colon Cancer: Prevention	1	2
Colorectal Cancer: Prevention	1	2
Colorectal Tumors	1	2
Congestive Heart Failure	1	2
Convulsions	1	2
Coronavirus Infection	2	2
Cytomegalovirus Infections	2	2
Degenerative Disk Disease	2	2
Demyelinating Diseases	1	2
Diabesity	1	2
Diabetic Neuropathies	1	2
Diarrhea: Drug-Associated	1	2
Drug-Induced Toxicity: Gastrointestinal	1	2
Drug-Induced Toxicity: L-Thyroxine	1	2
Drug-Induced Toxicity: Methotrexate	1	2
Endothelial Damage	1	2
Erectile Dysfunction	1	2
Fetal Origin of Adult Disease	1	2
Gastric Polyposis	1	2
Gastrointestinal Inflammation	1	2
Graft vs Host Disease	1	2
HIV Infections	2	2
Heavy Metal Toxicity	1	2
Hepatitis: Autoimmune	1	2
High Homocysteine	1	2
Huntington Disease	1	2
Hyperalgesia	1	2
Hypersensitivity: Type IV	1	2
Hypertension: Pulmonary	1	2
Hypertension: Renal	1	2
Hyperuricemia	1	2
Immune Dysregulation: TH1 dominance	1	2
Immune Dysregulation: TH17 over-expression	1	2
Infertility: Male	1	2
Insomnia	1	2
Intestinal Permeability	1	2
Intestinal Polyps	1	2
Intima Media Thickening	1	2
Iron Overload	1	2
Irritable Bowel Syndrome	1	2
Kidney Fibrosis	1	2
Lead Poisoning	1	2
Learning disorders	1	2
Leukemia	2	2
Lipid Peroxidation	1	2
Liver Steatosis	1	2
Liver Stress: Fructose-Induced	1	2
Lung Cancer: Prevention	1	2
Malignant Melanoma	2	2
Mastitis	1	2
Memory Disorders: Drug-Induced	1	2
Middle Cerebral Artery Occlusion (MCAO)	1	2
Miscarriage	1	2
Morphine Tolerance/Dependence	1	2
Mucositis	1	2
Multiple Myeloma	2	2
Multiple Sclerosis	1	2
Muscle Damage: Exercise-Induced	1	2
Myocardial Fibrosis	1	2
Myocarditis: Viral	1	2
Nerve Injuries	1	2
Neuroblastoma	2	2
Neuropathic Pain	1	2
Non-Small-Cell Lung Carcinoma	2	2
Osteoarthritis	2	2
Pancreatic Cancer	2	2
Parkinson's Disease	1	2
Peripheral Nerve Diseases	1	2
Pesticide Toxicity	1	2
Post-Traumatic Stress Disorders (PTSD)	1	2
Postmenopausal Disorders	1	2
Postoperative Recovery	1	2
Prehypertension	1	2
Promyelocytic leukemia	2	2
Prostate Cancer	2	2
Psychiatric Disorders	1	2
Retinal Diseases	1	2
Schizophrenia	1	2
Seizures	1	2
Seizures: Drug-Induced	1	2
Smoking Cessation: Nicotine Addiction	1	2
Staphylococcal Infections	1	2
Staphylococcus aureus infection	2	2
Staphylococcus aureus: Methicillin-resistant (MRSA)	2	2
Stroke: Ischemic	1	2
Tongue Cancer	1	2
Uremia	1	2
Uveoretinitis	1	2
Varicocele	1	2
Acute Myeloid Leukemia	1	1
Acute lymphoblastic leukemia (ALL)	1	1
Allergic Airway Diseases	1	1
Allergies	1	1
Alphavirus Infections	1	1
Arthritis: Rheumatoid	1	1
Bacillus Cereus infection	1	1
Bacterial Infections and Mycoses	1	1
Bladder Cancer	1	1
Breast Cancer Stem Cells	1	1
Breast Cancer: HER-2 Overexpressed	1	1
Cancer: Virus-Induced	1	1
Cancers: Multi-Drug Resistant	1	1
Cardiac Arrhythmias	1	1
Chemotherapy-Induced Kidney Damage	1	1
Chemotherapy-Induced Toxicity: Cisplatin	1	1
Cholangiocarcinoma	1	1
Cholesterol: Oxidation	1	1
Chondrosarcoma	1	1
Chronic Disease	1	1
Chronic Kidney Disease (CKD)	1	1
Chronic Lymphocytic Leukemia	1	1
Chronic Obstructive Pulmonary Disease	1	1
Clostridium Infections	1	1
Corticosteroid-Induced Toxicity	1	1
Dementia: Senile	1	1
Dental Caries	1	1
Diabetes Mellitus: Type 2: Prevention	1	1
Diabetes: Glycation/A1C	1	1
Diabetes: Kidney Function	1	1
Diarrhea: in Children	1	1
Dysbiosis	1	1
Echinococcosis	1	1
Enterococcus Infections	1	1
Enterovirus 71	1	1
Enterovirus: Type 71	1	1
Esophageal Cancer	1	1
Eye Diseases	1	1
Friend Virus	1	1
Fungal Infection	1	1
Gastrointestinal Cancer	1	1
HIV Drug-Induced Toxicity	1	1
Head and Neck Cancer	1	1
Herpes Simplex Virus Type 1	1	1
Herpes Simplex Virus Type 2	1	1
High Sugar Diet	1	1
Human Papillomavirus (HPV)	1	1
Hydatid Cyst	1	1
Inflammatory Bowel Diseases	1	1
Kawasaki Disease	1	1
Kidney Cancer	1	1
Kidney Damage	1	1
Laryngeal Cancer	1	1
Leaky Gut Syndrome	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Leukemia: Chronic Lymphocytic Leukemia (CLL)	1	1
Leukemia: Virus-Induced	1	1
Liver Damage	1	1
Lower Respiratory Infections	1	1
Lung Injury: Acute	1	1
Lymphangioendothelioma	1	1
Macular Degeneration	1	1
Mesothelioma	1	1
Microcystis aeruginosa	1	1
Myocarditis: Autoimmune	1	1
Oral Cancer	1	1
Overweight	1	1
Periodontal Diseases	1	1
Pulmonary Fibrosis	1	1
Respiratory Syncytial Virus Infections	1	1
Retinoblastoma	1	1
Rhabdomyosarcoma	1	1
Salmonella Infections	1	1
Skin Cancer: Squamous Cell	1	1
Squamous cell carcinoma	1	1
Streptococcus pyogenes	1	1
Subarachnoid hemorrhage	1	1
Thrombocytopenia	1	1
Thyroid Cancer	1	1

Name	AC	CK
Anti-Inflammatory Agents	134	266
Antiproliferative	79	116
Hypolipidemic	28	114
Antioxidants	64	107
Tumor Necrosis Factor (TNF) Alpha Inhibitor	45	99
Interleukin-6 Downregulation	43	93
Neuroprotective Agents	54	87
Apoptotic	62	72
Gastrointestinal Agents	25	71
Cardioprotective	28	64
Anticholesteremic Agents	9	60
Chemopreventive	23	59
Interleukin-1 beta downregulation	33	56
Hepatoprotective	29	54
Anti-Apoptotic	29	53
Hypoglycemic Agents	21	53
Anti-Bacterial Agents	12	42
NF-kappaB Inhibitor	28	41
MicroRNA modulator	27	39
Anti-metastatic	27	30
Renoprotective	16	27
Cell cycle arrest	23	26
Chemotherapeutic	22	24
Insulin Sensitizers	7	21
Chemosensitizer	18	19
Cyclooxygenase 2 Inhibitors	11	18
Autophagy Up-regulation	11	17
Gastroprotective	8	16
Immunomodulatory	12	16
Nrf2 activation	11	16
Antidiarrheals	4	14
Antineoplastic Agents	5	13
Antiviral Agents	11	13
Chemoprotective Agents	8	13
Anti-Fibrotic	7	12
Anticarcinogenic Agents	7	12
Matrix metalloproteinase-2 (MMP-2) inhibitor	10	12
Matrix metalloproteinase-9 (MMP-9) inhibitor	8	11
Antihypertensive Agents	6	10
Osteoprotective	6	10
Radioprotective	1	10
Antidepressive Agents	4	8
Antimicrobial	7	8
Interleukin-10 upregulation	4	8
Malondialdehyde Down-regulation	4	8
Pancreato Protective Agents	5	8
Tumor Suppressor Protein p53 Upregulation	7	8
Wnt/β-catenin signaling pathway modulation	7	8
Angiogenesis Inhibitors	5	7
Angiogenesis Inducing Agents	3	6
Anti-Adipogenic	5	6
Anti-Anxiety Agents	3	6
Anticonvulsants	3	6
Cytoprotective	4	6
Enzyme Inhibitors	2	6
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	5	6
Immunomodulatory: Th17 downregulation	3	6
STAT3 Inhibitor	4	5
Analgesics	2	4
Antifungal Agents	4	4
Bcl-2 protein down-regulation	4	4
Brain-derived neurotrophic factor modulator	2	4
Glucagon Like peptide 1 (GLP-1) Up-regulation	2	4
Heme oxygenase-1 up-regulation	3	4
Interleukin-10 downregulation	2	4
Interleukin-17 downregulation	2	4
Prostaglandin PGE2 downregulation	2	4
Radiosensitizer	3	4
Regenerative	3	4
Transforming growth factor beta (TGF-β) inhibitor	2	4
Vasoprotective	2	4
Anti-Glycation Agents	2	3
Anti-atherogenic	2	3
Caspase-3 Activation	2	3
Interleukin-8 downregulation	3	3
Matrix metalloproteinase-3 (MMP-3) inhibitor	2	3
Vascular Endothelial Growth Factor Inhibitors	3	3
Alpha-glucosidase inhibitor	2	2
Anti-Tumor	1	2
Bax/Bcl2 Ratio: Decrease	1	2
Caspase-9 Activation	1	2
Cholinesterase Inhibitors	1	2
Cytotoxic	2	2
Enzyme Inhibitors: Pancreatic Amylase	1	2
Enzyme Inhibitors: Pancreatic Lipase	1	2
Epidermal growth factor receptor (EGFR) inhibitor	1	2
Fertility Agents: Male	1	2
Fibroblast growth factor 21 upregulation	1	2
Immunosuppressive Agents	1	2
Interferon Gamma Reducer	1	2
Interleukin-1 alpha downregulation	2	2
Interleukin-4 downregulation	1	2
Interleukin-4 upregulation	1	2
Iron Chelating Agents	1	2
Leishmanicidal	1	2
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	2	2
Neuritogenic	1	2
Nitric Oxide Inhibitor	1	2
P21 Activation	2	2
Photosensitizing Agents	2	2
SIRT1 Activator	1	2
Uricosuric Agents	1	2
Wnt/β-catenin pathway down-regulation	1	2
interleukin-13 down-regulation	1	2
AMP-activated protein kinase modulation	1	1
Acetylcholinesterase Inhibitor	1	1
Alpha-amylase inhibitor	1	1
Anti-Allergic Agents	1	1
Anti-Androgen	1	1
Anti-Proliferative	1	1
Antioxidant Effects	1	1
Autophagy Inhibitors	1	1
Cyclin D1 Down-Regulation	1	1
Cyclin-dependent kinase inhibitor: P16INK4	1	1
Expectorants	1	1
Gluconeogenesis Inhibitor	1	1
HIV Protease Inhibitors	1	1
Interleukin-18 down-regulation	1	1
Matrix metalloproteinase-1 (MMP-1) inhibitor	1	1
Multidrug Resistance Gene Modulators	1	1
Osteogenic	1	1
P38 Mitogen-Activated Protein Kinase Modulator	1	1
Prophylactic Agents	1	1
RANK Downregulation	1	1
Scolicidal	1	1
Survivin Down-Regulation	1	1
Telomerase Inhibitor	1	1

[+]

Improving sciatic nerve regeneration by using alginate/chitosan hydrogel containing berberine.Oct 08, 2020

Click here to read the entire abstract

Pubmed Data : Drug Deliv Transl Res. 2020 Oct 9. Epub 2020 Oct 9. PMID: 33034886

Article Published Date : Oct 08, 2020

Study Type : In Vitro Study

Additional Links

Substances : Berberine

Diseases : Peripheral Neuropathies

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Nerve Regeneration

[+]

In situ gelling hydrogel loaded with berberine liposome for the treatment of biofilm-infected wounds.Dec 31, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Curr Drug Deliv. 2023 Oct 6. Epub 2023 Oct 6. PMID: 37815182

Article Published Date : Oct 05, 2023

Study Type : In Vitro Study

Additional Links

Substances : Berberine

Diseases : Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Enhancer

[+]

Low dose berberine suppresses cholangiocarcinoma cell progression.Sep 30, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Life Sci. 2020 Feb 1 ;242:117228. Epub 2019 Dec 24. PMID: 31881227

Article Published Date : Jan 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Berberine

Diseases : Acute T cell Leukemias

Pharmacological Actions : Apoptotic, Tumor Suppressor Protein p53 Upregulation

[+]

Mechanism of berberine-mediated fluconazole-susceptibility enhancement in clinical fluconazole-resistant Candida tropicalis isolates.Jul 08, 2017

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Pubmed Data : Biomed Pharmacother. 2017 Jul 9 ;93:709-712. Epub 2017 Jul 9. PMID: 28700974

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncotarget. 2015 Nov 27. Epub 2015 Nov 27. PMID: 26672764

Article Published Date : Nov 26, 2015

Study Type : In Vitro Study

Additional Links

Substances : Berberine, Melatonin

Diseases : Lung Cancer, Non-Small-Cell Lung Carcinoma

Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Antiproliferative , Apoptotic, Chemosensitizer, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor

Additional Keywords : Natural Substance Synergy

[+]

Methyltransferase SETD2 mediates hepatoprotection of berberine against steatosis.Apr 30, 2022

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Pubmed Data : Cells. 2022 Oct 31 ;11(21). Epub 2022 Oct 31. PMID: 36359829

Article Published Date : Oct 30, 2022

Study Type : Review

Additional Links

Substances : Berberine

Diseases : Lung Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative

Additional Keywords : Tumor Microenvironment

[+]

Click here to read the entire abstract

Pubmed Data : J Food Biochem. 2021 Sep 14:e13936. Epub 2021 Sep 14. PMID: 34523148

Article Published Date : Sep 13, 2021

Study Type : Review

Additional Links

Substances : Berberine

Diseases : Alzheimer's Disease

Pharmacological Actions : Neuroprotective Agents

[+]

Neuroprotective properties of berberine: molecular mechanisms and clinical implications.Oct 18, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Antioxidants (Basel). 2023 Oct 19 ;12(10). Epub 2023 Oct 19. PMID: 37891961

Article Published Date : Oct 18, 2023

Study Type : Review

Additional Links

Substances : Berberine

Diseases : Brain Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents

[+]

Novel regulation of miR-34a-5p and HOTAIR by the combination of berberine and gefitinib leading to inhibition of EMT in human lung cancer.Apr 04, 2020

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Pubmed Data : J Cell Mol Med. 2020 Apr 5. Epub 2020 Apr 5. PMID: 32248643

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Pubmed Data : Evid Based Complement Alternat Med. 2021 ;2021:9987097. Epub 2021 Aug 21. PMID: 34471420

Article Published Date : Dec 31, 2020

Study Type : Review

Additional Links

Substances : Berberine

Diseases : Hyperglycemia

Pharmacological Actions : Anti-Inflammatory Agents, Hypoglycemic Agents

[+]

Polycystic ovary syndrome management: a review of the possible amazing role of berberine.Dec 31, 2019

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Pubmed Data : Crit Rev Oncol Hematol. 2017 Aug ;116:147-158. Epub 2017 Jun 13. PMID: 28693796

Article Published Date : Jul 31, 2017

Study Type : Review

Additional Links

Substances : Berberine

Diseases : Colorectal Cancer, Diabetes Mellitus: Type 2, Gastric Cancer, Glioblastoma, Liver Cancer, Multiple Myeloma, Ovarian Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, MicroRNA modulator

[+]

The anti-proliferative activity of the her Coptidis rhizoma against eight human pancreatic cancer cell lines is largely due to the presence of the phytochemical berberine. Jul 15, 2005

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Pubmed Data : Life Sci. 2005 Jul 15;77(9):991-1002. Epub 2005 Apr 20. PMID: 15964315

Article Published Date : Jul 15, 2005

Study Type : In Vitro Study

Additional Links

Substances : Berberine, Coptidis rhizoma

Diseases : Pancreatic Cancer

[+]

The Berberis vulgaris L. extract berberine exerts its anti-oxidant effects to ameliorate cholesterol overloading-induced cell apoptosis.Nov 30, 2022

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Pubmed Data : In Vitro Cell Dev Biol Anim. 2022 Dec ;58(10):855-866. Epub 2022 Dec 8. PMID: 36481977

Article Published Date : Nov 30, 2022

Study Type : In Vitro Study

Additional Links

Substances : Berberine

Diseases : Cardiovascular Diseases, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation

[+]

The combination of berberine and ciprofloxacin showed synergistic effect and more effective to inhibit Salmonella biofilm formation.Oct 07, 2018

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Rep. 2016 Apr ;4(4):449-452. Epub 2016 Feb 23. PMID: 27073630

Article Published Date : Mar 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Berberine

Diseases : Candida Albicans

Pharmacological Actions : Antifungal Agents

[+]

The present study showed that berberine, baicalin, emodin, and schizandrin all have antibacterial activities against MDR, and can reduce the MICs of amoxicillin and tetracycline.Apr 13, 2015

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Pubmed Data : J Cell Biochem. 2019 Oct 14. Epub 2019 Oct 14. PMID: 31609017

Article Published Date : Oct 13, 2019

Study Type : Review

Additional Links

Substances : Berberine

Diseases : Cancers: All, Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antidiarrheals, Antimicrobial, Antioxidants, Chemotherapeutic, Nrf2 activation

[+]

Therapeutic effect of berberine on metabolic diseases.Nov 09, 2020

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Pubmed Data : Cell Death Dis. 2017 Oct 5 ;8(10):e3070. Epub 2017 Oct 5. PMID: 28981112

Article Published Date : Oct 04, 2017

Study Type : In Vitro Study

Additional Links

Substances : Berberine

Diseases : Ovarian Cancer

Pharmacological Actions : Chemosensitizer, Chemotherapeutic

[+]

[+]

These results indicate that berberine can promote nerve regeneration.Sep 23, 2018

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Pubmed Data : Mol Med Rep. 2018 Sep 24. Epub 2018 Sep 24. PMID: 30272344

Article Published Date : Sep 23, 2018

Study Type : In Vitro Study

Additional Links

Substances : Berberine

Diseases : Alzheimer's Disease

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation

Additional Keywords : Nerve Regeneration

[+]

These results shed light on berberine's potential as an anti-tumor agent for clinical cancer therapy.Nov 14, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Phytomedicine. 2016 Jun 15 ;23(7):736-44. Epub 2016 Apr 13. PMID: 27235712

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Pubmed Data : Am J Chin Med. 2019 May 16:1-17. Epub 2019 May 16. PMID: 31094214

Article Published Date : May 15, 2019

Study Type : Review

Additional Links

Substances : Berberine

Diseases : Hyperlipidemia

Pharmacological Actions : Hypolipidemic

[+]

This work supports berberine as a putative anti-tumor agent targeting glioma cells.Dec 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Oncol. 2019 ;9:364. Epub 2019 May 14. PMID: 31139563

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Berberine

Diseases : Glioma

Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Interleukin-18 down-regulation, Interleukin-1 beta downregulation

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View the Evidence: 1022 Abstracts with Berberine Research

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Improving sciatic nerve regeneration by using alginate/chitosan hydrogel containing berberine.Oct 08, 2020

In situ gelling hydrogel loaded with berberine liposome for the treatment of biofilm-infected wounds.Dec 31, 2022

In this review, we systematically summarize the scientific evidence about BBR's antidiabetic mechanisms, its clinical effectiveness, and safety in the treatment of T2DM.Dec 31, 2014

In vitro antimicrobial activity and the mechanism of berberine against methicillin-resistant Staphylococcus aureus.Dec 31, 2021

In-vitro synergistic effect of metformin and berberine on high glucose-induced lipogenesis.Dec 31, 2018

Increased bioavailable berberine protects against myocardial ischemia reperfusion injury.Oct 09, 2018

Inhibition of hepatocellular carcinoma growth via modulation of the miR-221/SOX11 axis by curcumin and berberine.Dec 31, 2022

Inhibitory effects of berberine on proinflammatory M1 macrophage polarization through interfering with the interaction between TLR4 and MyD88.Nov 18, 2019

Inhibitory role of berberine on NLRP3 inflammasome activation for the treatment of inflammatory diseases.Oct 14, 2021

Intracellular accumulations of berberine in NSCLC cell lines H1650 and H1975 were 2-3 folds higher than that of normal epithelial cells.Oct 31, 2015

Investigation of antioxidant and anti-inflammatory properties of berberine nanomicelles.Oct 05, 2023

Low dose berberine suppresses cholangiocarcinoma cell progression.Sep 30, 2022

Low molecular weight fucoidan modified nanoliposomes for the targeted delivery of the anti-inflammation natural product berberine.Jul 24, 2023

Low-dose berberine attenuates the anti-breast cancer activity of chemotherapeutic agents.Sep 30, 2020

MDM2 inhibition-mediated autophagy contributes to the pro-apoptotic effect of berberine in p53-null leukemic cells.Jan 31, 2020

Mechanism of berberine-mediated fluconazole-susceptibility enhancement in clinical fluconazole-resistant Candida tropicalis isolates.Jul 08, 2017

Mechanism of natural drugs on nonalcoholic fatty liver disease.Apr 04, 2021

Mechanisms of berberine for the treatment of atherosclerosis based on network pharmacology.Dec 31, 2019

Melatonin enhanced the antitumor activity of berberine in lung cancer cells.Nov 26, 2015

Methyltransferase SETD2 mediates hepatoprotection of berberine against steatosis.Apr 30, 2022

Modulation of antioxidant defense system in response to berberine in Candida albicans.Nov 02, 2020

Molecular updates on berberine in liver diseases: Bench to bedside.May 30, 2021

Multi-target potential of berberine as an antineoplastic and antimetastatic agent.Oct 30, 2022

Multi-target regulation of intestinal microbiota by berberine to improve type 2 diabetes mellitus.Dec 31, 2021

Multi-target treatment of senile dementia by berberine is a potential avenue of study for senile dementia treatment.Aug 25, 2015

Nanoparticles of ZnO/Berberine complex contract COVID-19 and respiratory co-bacterial infection in addition to elimination of hydroxychloroquine toxicity.Sep 05, 2021

Natural alkaloid berberine activity against pseudomonas aeruginosa MexXY-mediated aminoglycoside resistance.Jul 04, 2019

Natural anti-inflammatory compounds as treatment candidates in Alzheimer’s disease. Jul 29, 2020

Natural berberine-derived azolyl ethanols as new structural antibacterial agents against drug-resistant escherichia coli.Dec 28, 2021

Naturally occurring molecules discussed in the present article are potential anti-myocarditis treatments.Jul 26, 2017

Naturally occurring proteinaceous nanoparticles in Coptidis Rhizoma extract act as concentration-dependent carriers facilitating berberine absorption.Dec 31, 2015

Nature-derived compounds modulating Wnt/ β -catenin pathway.Sep 30, 2020

Neuroprotective potential of berberine in modulating Alzheimer's disease via multiple signaling pathways.Sep 13, 2021

Neuroprotective properties of berberine: molecular mechanisms and clinical implications.Oct 18, 2023

Novel regulation of miR-34a-5p and HOTAIR by the combination of berberine and gefitinib leading to inhibition of EMT in human lung cancer.Apr 04, 2020

Nutraceuticals may enhance other anti-cancer drugs to suppress proliferation of cancer cells.Oct 02, 2017

Oncosis-like cell death is induced by berberine through ERK1/2-mediated impairment of mitochondrial aerobic respiration in gliomas.Mar 27, 2018

Pharmacokinetics and pharmacodynamics of Huanglian-Houpo decoction based on berberine hydrochloride and magnolol against H1N1 influenza virus. Oct 11, 2021

Pharmacokinetics and pharmacological activities of berberine in diabetes mellitus treatment.Dec 31, 2020

Polycystic ovary syndrome management: a review of the possible amazing role of berberine.Dec 31, 2019

Polyphenols may have therapeutic value in a variety of diseases through modulating AMP-activated protein kinase which reduce fatty acid and cholesterol synthesis and gluconeogenesis. Oct 01, 2009

Potential cytotoxic and anti-metastatic effects of berberine on gynaecological cancers with drug-associated resistance.Jan 31, 2020

Potential prophylactic effect of berberine against rat colon carcinoma induce by 1,2-dimethyl hydrazine.Jun 24, 2018

Potential protective roles of phytochemicals on glutamate-induced neurotoxicity.Aug 31, 2020

Potentiating the activity of berberine for Staphylococcus aureus in a combinatorial treatment with thymol.Sep 29, 2020

Potentiation and mechanism of berberine as an antibiotic adjuvant against multidrug-resistant bacteria.Dec 31, 2022

Pre-treatment with berberine could alleviate hydrogen peroxide induced apoptosis in rat bone marrow-derived mesenchymal stem cells.Nov 30, 2016

Pre-treatment with berberine enhances effect of 5-fluorouracil and cisplatin in HEP2 laryngeal cancer cell line.Dec 31, 2017

Preventive and therapeutic roles of berberine in gastrointestinal cancers.Dec 31, 2018

Promising anti-atherosclerotic effect of berberine.Aug 13, 2020

Promising antioxidative effect of berberine in cardiovascular diseases. Dec 31, 2021

Protective effect of berberine against LPS-induced injury in the intestine.Jul 18, 2022

Protective effect of berberine on high glucose and hypoxia-induced apoptosis.Dec 31, 2018

Protective effects of berberine against β-amyloid-induced neurotoxicity in HT22 cells.Oct 21, 2022

Protective effects of berberine in a model of polycystic ovary syndrome.Mar 10, 2021

Protective effects of berberine on various kidney diseases.Jun 15, 2022

Protective role of berberine on ulcerative colitis through modulating enteric glial cells-intestinal epithelial cells-immune cells interactions.Feb 29, 2020

Raman spectrum spectral imaging revealing the molecular mechanism of Berberine-induced Jurkat cell apoptosis.Mar 31, 2019

Regulatory effects of berberine on microRNome in cancer and other conditions.Jul 31, 2017

Research progress on antidepressant effects and mechanisms of berberine.Dec 31, 2023

Resveratrol, EGCG, berberine and alpha-lipoic acid may have a beneficial effect on bone health through negatively regulating RANKL.Nov 01, 2010

SOCS1 mediates berberine-induced amelioration of microglial activated states in N9 microglia exposed to β Amyloid.Dec 31, 2020

Solid lipid nanoformulation of berberine attenuates Doxorubicin triggered in vitro inflammation in H9c2 cardiomyocytes.Jun 16, 2022

Study on the mechanisms of action of berberine combined with fluconazole against fluconazole-resistant strains of Talaromyces marneffei.Dec 31, 2021

Synergetic protective effect of berberine and ginsenoside Rb1 against tumor necrosis factor alpha-induced inflammation in adipocytes.Oct 25, 2021

Synergistic antibacterial activity of berberine in combination with amylmetacresol against Enterococcus faecalis.Oct 31, 2020

Synergistic effect of berberine hydrochloride and fluconazole against Candida albicans resistant isolates.Dec 31, 2019

Synergistic effect of TPD7 and berberine against leukemia jurkat cell growth.Jul 11, 2017

Synergistic inhibitory effect of berberine and icotinib on non-small cell lung cancer cells via inducing autophagic cell death and apoptosis.Jan 11, 2021

Synergistic inhibitory effect of berberine and low-temperature plasma on non-small-cell lung cancer cells.Nov 26, 2023

Tackling strong biofilm and multi-virulent vancomycin-resistant Staphylococcus aureus via berberine-loaded mesoporous silica nanoparticles.Dec 31, 2022

The above results indicate berberine could suppress mast cell activation and allergic responses.Mar 08, 2019

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1022 Abstracts with Berberine Research