Black Pepper

Black Pepper

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View the Evidence: Substances

Fragrance inhalation of patchouli and rose oil reduce sympathetic nervous system activity by 40%; rose oil reduces adrenaline concentrations by 30%.

Pubmed Data : Jpn J Pharmacol. 2002 Nov;90(3):247-53. PMID: 12499579
Article Published Date : Nov 01, 2002
Study Type : Human Study
Additional Links
Substances : Black Pepper : CK(88) : AC(35), Patchouli : CK(15) : AC(6), Rose : CK(106) : AC(25)
Diseases : Adrenaline: Elevated : CK(10) : AC(1), Adrenaline: Low : CK(10) : AC(1), Catecholamines: Elevated : CK(76) : AC(10), Catecholamines: Low : CK(10) : AC(1), Hypertension : CK(2783) : AC(271), Sympathetic Nervous System Diseases : CK(10) : AC(1)
Therapeutic Actions : Aromatherapy : CK(371) : AC(37)

Inhalation of vapor from black pepper reduces smoking withdrawal symptoms.

Pubmed Data : Drug Alcohol Depend. 1994 Feb;34(3):225-9. PMID: 8033760
Article Published Date : Feb 01, 1994
Study Type : Human Study
Additional Links
Substances : Black Pepper : CK(88) : AC(35)
Diseases : Smoking Cessation : CK(93) : AC(11), Smoking Cessation: Nicotine Addiction : CK(111) : AC(16)
Therapeutic Actions : Aromatherapy : CK(371) : AC(37)

A combination of nutrients improves cognitive functioning while decreasing Alzheimer disease neuropathology in an animal model.

Pubmed Data : PLoS One. 2010;5(11):e14015. Epub 2010 Nov 17. PMID: 21103342
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Alpha-Lipoic Acid : CK(384) : AC(82), B-complex : CK(278) : AC(32), Curcumin : CK(2910) : AC(1482), EGCG (Epigallocatechin gallate) : CK(859) : AC(109), Folic Acid : CK(542) : AC(77), NAC (N-acetyl-L-cysteine) : CK(264) : AC(62), Piperine : CK(29) : AC(14), Vitamin C : CK(1274) : AC(238)
Diseases : Alzheimer's Disease : CK(826) : AC(160)
Pharmacological Actions : Neuroprotective Agents : CK(962) : AC(480)

Black pepper and cardamom have immunomodulatory and anti-cancer

Pubmed Data : J Med Food. 2010 Apr;13(2):371-81. PMID: 20210607
Article Published Date : Apr 01, 2010
Study Type : Animal Study
Additional Links
Substances : Black Pepper : CK(88) : AC(35), Cardamom : CK(16) : AC(5)
Diseases : Cancers: All : CK(9062) : AC(2869), Low Immune Function: Natural Killer Cells : CK(108) : AC(21)
Pharmacological Actions : Immunomodulatory : CK(536) : AC(142)

Black pepper and Vinca rosea protect against alloxan induced diabetes.

Pubmed Data : Indian J Physiol Pharmacol. 2005 Jan;49(1):65-71. PMID: 15881860
Article Published Date : Jan 01, 2005
Study Type : Animal Study
Additional Links
Substances : Black Pepper : CK(88) : AC(35), Vinca Rosea : CK(4) : AC(2)
Diseases : Alloxan toxicity : CK(12) : AC(6), Diabetes Mellitus: Type 1 : CK(1107) : AC(218)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Black pepper has antispasmodic properties.

Pubmed Data : Pak J Biol Sci. 2008 Jun 1;11(11):1492-6. PMID: 18817253
Article Published Date : Jun 01, 2008
Study Type : Animal Study
Additional Links
Substances : Black Pepper : CK(88) : AC(35)
Diseases : Gastrointestinal Diseases : CK(38) : AC(14)
Pharmacological Actions : Antispasmodic : CK(112) : AC(29)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Black pepper is a potential inducer of detoxification, indicating its role as a chemopreventive in chemical carcinogenesis.

Pubmed Data : Cancer Lett. 1993 Aug 16;72(1-2):5-9. PMID: 8402574
Article Published Date : Aug 16, 1993
Study Type : Animal Study
Additional Links
Substances : Black Pepper : CK(88) : AC(35)
Diseases : Cancers: All : CK(9062) : AC(2869), Liver Cancer : CK(1641) : AC(266)
Pharmacological Actions : Detoxifier : CK(306) : AC(101)

Black pepper may have a therapeutic role in the treatment of gastrointestinal disorders.

Pubmed Data : Anticancer Res. 2009 Dec;29(12):4981-8. PMID: 20828313
Article Published Date : Dec 01, 2009
Study Type : Animal Study
Additional Links
Substances : Black Pepper : CK(88) : AC(35)
Diseases : Gastrointestinal Diseases : CK(38) : AC(14)
Pharmacological Actions : Antispasmodic : CK(112) : AC(29)

Black Pepper reduces high-fat diet induced oxidative stress.

Pubmed Data : Redox Rep. 2004;9(2):105-10. PMID: 15231065
Article Published Date : Jan 01, 2004
Study Type : Animal Study
Additional Links
Substances : Black Pepper : CK(88) : AC(35), Piperine : CK(29) : AC(14)
Diseases : Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

Cucumin and piperine in combination have a potent antigenotoxic effect as compared to either agent alone in DMBA-induced genotoxicity in golden Syrian hamsters.

Pubmed Data : Toxicol Mech Methods. 2008 Jan;18(9):691-6. PMID: 20020926
Article Published Date : Jan 01, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482), Piperine : CK(29) : AC(14)
Diseases : DNA damage : CK(711) : AC(293), Myelotoxicity : CK(31) : AC(8)
Pharmacological Actions : Genoprotective : CK(116) : AC(48)
Additional Keywords : Natural Substance Synergy : CK(144) : AC(81)

Cumin and black pepper prevent chemically-induced rat colon carcinogenesis.

Pubmed Data : J Med Food. 2006;9(2):237-45. PMID: 16822210
Article Published Date : Jan 01, 2006
Study Type : Animal Study
Additional Links
Substances : Black Pepper : CK(88) : AC(35), Cumin : CK(32) : AC(21)
Diseases : Colon Cancer : CK(895) : AC(233)
Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Chemopreventive : CK(1528) : AC(382)

Curcumin (from Turmeric) in combination with Piperine may attenuate stress-induced depression.

Pubmed Data : Pharmacol Biochem Behav. 2008 Oct 25. [Epub ahead of print] PMID: 19000708
Article Published Date : Oct 25, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482), Piperine : CK(29) : AC(14)
Diseases : Depression : CK(674) : AC(88)

Dietary ginger and other spice compounds enhance fat digestion and absorption in high-fat fed situation through enhanced secretion of bile salts and a stimulation of the activity pancreatic lipase.

Pubmed Data : J Sci Food Agric. 2011 Sep 14. Epub 2011 Sep 14. PMID: 21918995
Article Published Date : Sep 13, 2011
Study Type : Animal Study
Additional Links
Substances : Capsaicin : CK(60) : AC(34), Ginger : CK(310) : AC(89), Piperine : CK(29) : AC(14)
Diseases : Fat Malabsorption : CK(2) : AC(1), Indigestion: Fats : CK(2) : AC(1), Steatorrhea : CK(12) : AC(2)
Pharmacological Actions : Enzyme Inhibitors: Pancreatic Lipase : CK(12) : AC(2)

Dietary spices have a beneficial effect on intestinal villi by increasing the absorptive surface of the small intestine, providing for an increased bioavailability of micronutrients.

Pubmed Data : Br J Nutr. 2010 Feb 24:1-9. Epub 2010 Feb 24. PMID: 20178671
Article Published Date : Feb 24, 2010
Study Type : Animal Study
Additional Links
Substances : Black Pepper : CK(88) : AC(35), Capsaicin : CK(60) : AC(34), Ginger : CK(310) : AC(89), Piperine : CK(29) : AC(14), Red Pepper : CK(4) : AC(2)
Diseases : Malabsorption Syndrome : CK(34) : AC(11), Microvilli atrophy : CK(4) : AC(1)
Additional Keywords : Nutrient Absorption : CK(4) : AC(2)

Piperine and Curcumin (from Turmeric) attenuates Cadmium induced immunotoxicity.

Pubmed Data : Biometals. 2008 Dec;21(6):649-61. Epub 2008 Jun 20. PMID: 18566892
Article Published Date : Dec 01, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482), Piperine : CK(29) : AC(14)
Diseases : Cadmium Poisoning : CK(64) : AC(30)

Piperine can relieve depression in rats by modulating the function of HPA axis.

Pubmed Data : Zhong Xi Yi Jie He Xue Bao. 2009 Jul;7(7):667-70. PMID: 19615322
Article Published Date : Jul 01, 2009
Study Type : Animal Study
Additional Links
Substances : Piperine : CK(29) : AC(14)
Diseases : Depression : CK(674) : AC(88), HPA Axis Dysregulation : CK(71) : AC(11)
Pharmacological Actions : Antidepressive Agents : CK(142) : AC(31), Neuroprotective Agents : CK(962) : AC(480)

Piperine exhibit chempreventive effects in chemically-induced lung cancer in mice.

Pubmed Data : Mol Cell Biochem. 2005 Mar;271(1-2):101-6. PMID: 15881660
Article Published Date : Mar 01, 2005
Study Type : Animal Study
Additional Links
Substances : Black Pepper : CK(88) : AC(35), Piperidines : CK(45) : AC(17)
Diseases : Lung Cancer : CK(496) : AC(198)
Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Chemopreventive : CK(1528) : AC(382)

Piperine may extend its chemopreventive effect through modulating the protein bound carbohydrate levels, as they are one of the indicators of tumorigenesis.

Pubmed Data : Pulm Pharmacol Ther. 2006;19(2):107-11. Epub 2005 Jun 21. PMID: 15975841
Article Published Date : Jan 01, 2006
Study Type : Animal Study
Additional Links
Substances : Black Pepper : CK(88) : AC(35), Piperidines : CK(45) : AC(17)
Diseases : Benzo[a]pyrene-induced Toxicity : CK(62) : AC(33), Lung Cancer : CK(496) : AC(198)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antioxidants : CK(3653) : AC(1318)

Piperine reduces DNA damage and DNA-protein cross links in experimentally induced lung carcinogenesis.

Pubmed Data : J Dent. 2008 Nov;36(11):900-6. Epub 2008 Sep 25. PMID: 15724447
Article Published Date : Nov 01, 2008
Study Type : Animal Study
Additional Links
Substances : Piperine : CK(29) : AC(14)
Diseases : Lung Cancer : CK(496) : AC(198)

Piperine reduces symptoms of human metabolic syndrome in HCHF-fed rats by reducing inflammation and oxidative stress.

Pubmed Data : Cell Biochem Biophys. 2011 Oct 30. Epub 2011 Oct 30. PMID: 22038304
Article Published Date : Oct 30, 2011
Study Type : Animal Study
Additional Links
Substances : Piperine : CK(29) : AC(14)
Diseases : Inflammation : CK(1077) : AC(363), Liver Fibrosis : CK(341) : AC(74), Metabolic Syndrome X : CK(645) : AC(122), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Antioxidants : CK(3653) : AC(1318)

Piperine supplementation markedly protects erythrocytes from oxidative stress by improving the antioxidant status in high fat fed antithyroid drug treated rats.

Pubmed Data : Cell Biochem Funct. 2006 Nov-Dec;24(6):491-8. PMID: 16927417
Article Published Date : Nov 01, 2006
Study Type : Animal Study
Additional Links
Substances : Black Pepper : CK(88) : AC(35), Piperidines : CK(45) : AC(17)
Diseases : Hyperlipidemia : CK(1211) : AC(109), Hyperthyroidism : CK(189) : AC(33), Thyroid Diseases : CK(182) : AC(23)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)
Additional Keywords : Antithyroid Drugs : CK(2) : AC(1)

Piperine, a major component of black pepper, inhibits cadmium-induced immunsuppression.

Pubmed Data : Biochem Pharmacol. 2006 Aug 14;72(4):486-97. Epub 2006 Jun 14. PMID: 16780805
Article Published Date : Aug 14, 2006
Study Type : Animal Study
Additional Links
Substances : Black Pepper : CK(88) : AC(35), Piperidines : CK(45) : AC(17)
Diseases : Cadmium Poisoning : CK(64) : AC(30), Heavy Metal Toxicity : CK(607) : AC(177), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114)

Piperine, a major component of black pepper, inhibits lipopolysaccharide-induced inflammation.

Pubmed Data : Eur J Pharmacol. 2010 Sep 10;642(1-3):154-62. Epub 2010 Jun 8. PMID: 20621590
Article Published Date : Sep 10, 2010
Study Type : Animal Study
Additional Links
Substances : Black Pepper : CK(88) : AC(35), Piperine : CK(29) : AC(14)
Diseases : Endotoxemia : CK(187) : AC(40), Lipopolysaccharide-Induced Toxicity : CK(227) : AC(128)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433)

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