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Chrysin

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Article Count - 12
Cumulative Knowledge - 17

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Quick Summary: Current access displays 2 out of 19 associated Diseases

Name	Cumulative Knowledge	Article Count	Focus Articles
Cancers: All	3	3	Log in \| Sign up
ALT: Elevated	2	1	Log in \| Sign up

Quick Summary: Current access displays 2 out of 17 associated Pharmacological Actions

Name	Cumulative Knowledge	Article Count	Focus Articles
Apoptotic	5	5	Log in \| Sign up
Hepatoprotective	4	2	Log in \| Sign up

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View the Evidence: Substances

Chrysin has a positive influence on hepatic marker enzymes in chemically-induced liver toxicity in rats.

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Pubmed Data : Food Chem Toxicol. 2010 Mar 31. Epub 2010 Mar 31. PMID: 20362027

Article Published Date : Mar 31, 2010

Study Type : Animal Study

Additional Links

Substances : Chrysin : CK(15) : AC(12)

Diseases : ALT: Elevated : CK(60) : AC(10), Chemically-Induced Liver Damage : CK(475) : AC(175), Gamma-glutamyl transpeptidase: Elevated : CK(4) : AC(2), GGT : CK(73) : AC(10), Results for Liver Enzymes: Elevated AST : CK(34) : AC(4)

Pharmacological Actions : Hepatoprotective : CK(557) : AC(272)

Chrysin protects against free radical-mediated oxidative stress in rats with ethanol-induced liver injury.

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Pubmed Data : J Pharm Pharmacol. 2009 Jun;61(6):809-17. PMID: 19505373

Article Published Date : Jun 01, 2009

Study Type : Animal Study

Additional Links

Substances : Chrysin : CK(15) : AC(12)

Diseases : Alcohol Toxicity : CK(212) : AC(85), Alcoholic Liver Disease : CK(146) : AC(50), Liver Cirrhosis: Alcoholic : CK(33) : AC(5)

Pharmacological Actions : Glutathione Upregulation : CK(144) : AC(48), Hepatoprotective : CK(557) : AC(272)

Chrysin suppresses experimentally-induced renal carcinogenesis.

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Pubmed Data : Toxicol Lett. 2012 Nov 26. Epub 2012 Nov 26. PMID: 23194824

Article Published Date : Nov 25, 2012

Study Type : Animal Study

Additional Links

Substances : Chrysin : CK(15) : AC(12)

Diseases : Kidney Cancer: Prevention : CK(2) : AC(1)

Pharmacological Actions : Chemopreventive : CK(1528) : AC(382)

Propolis and single flavonoids, caffeic acid, chrysin and naringin are radioprotective against gamma-irradiation.

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Pubmed Data : Biol Pharm Bull. 2008 Jan;31(1):167-72. PMID: 18175964

Article Published Date : Jan 01, 2008

Study Type : Animal Study

Additional Links

Substances : Bee Propolis : CK(220) : AC(83), Caffeic Acid : CK(15) : AC(11), Chrysin : CK(15) : AC(12), Citrus naringin : CK(12) : AC(8)

Diseases : DNA damage : CK(711) : AC(293), Radiation Induced Illness : CK(1018) : AC(249)

Pharmacological Actions : Radioprotective : CK(456) : AC(183)

Apigenin, chrysin, and luteolin may inhibit tumor cells via proteasome inhibitory activity.

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Pubmed Data : Planta Med. 2010 Feb;76(2):128-32. Epub 2009 Aug 3. PMID: 19653143

Article Published Date : Feb 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Apigenin : CK(76) : AC(51), Chrysin : CK(15) : AC(12), Luteolin : CK(62) : AC(51)

Diseases : Cancers: All : CK(9062) : AC(2869), Tumors : CK(197) : AC(110)

Pharmacological Actions : Enzyme Inhibitors : CK(372) : AC(208), Proteasome Inhibitors : CK(41) : AC(27)

Chrysin has novel anti-cancer properties.

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Pubmed Data : J Manipulative Physiol Ther. 1993 Mar-Apr;16(3):169-73. PMID: 20133051

Article Published Date : Mar 01, 1993

Study Type : In Vitro Study

Additional Links

Substances : Chrysin : CK(15) : AC(12)

Diseases : Cancers: All : CK(9062) : AC(2869)

Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), NF-kappaB Inhibitor : CK(595) : AC(401), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Chrysin suppresses lipopolysaccharide-induced inflammation.

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Pubmed Data : FEBS Lett. 2005 Jan 31;579(3):705-11. PMID: 15670832

Article Published Date : Jan 31, 2005

Study Type : In Vitro Study

Additional Links

Substances : Chrysin : CK(15) : AC(12), Flavonoids : CK(909) : AC(289)

Diseases : Inflammation : CK(1077) : AC(363), Lipopolysaccharide-Induced Toxicity : CK(227) : AC(128)

Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Chemopreventive : CK(1528) : AC(382), Cyclooxygenase 2 Inhibitors : CK(269) : AC(169), Interleukin-6 Downregulation : CK(470) : AC(135)

Flavanoid rich honey may act as chemosensitizers in multidrug resistant cancers.

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Pubmed Data : Med Hypotheses. 2011 Jan 17. Epub 2011 Jan 17. PMID: 21247706

Article Published Date : Jan 17, 2011

Study Type : In Vitro Study

Additional Links

Substances : Biochanin A : CK(9) : AC(8), Chrysin : CK(15) : AC(12), Flavonoids : CK(909) : AC(289), Genistein : CK(450) : AC(174), Honey : CK(251) : AC(50), Kaempferol : CK(27) : AC(22), Naringenin : CK(17) : AC(12), Quercetin : CK(318) : AC(136)

Diseases : Cancers: Multi-Drug Resistant : CK(92) : AC(73)

Pharmacological Actions : Chemosensitizer : CK(197) : AC(159)

Flavones and flavonols induces cell cycle arrest and programmed cell death in a human esophageal squamous cell carcinoma cell line.

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Pubmed Data : Toxicol In Vitro. 2009 Aug;23(5):797-807. Epub 2009 May 3. PMID: 19397994

Article Published Date : Aug 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Apigenin : CK(76) : AC(51), Chrysin : CK(15) : AC(12), Kaempferol : CK(27) : AC(22), Luteolin : CK(62) : AC(51), Myricetin : CK(7) : AC(6), Quercetin : CK(318) : AC(136)

Diseases : Esophageal Cancer : CK(328) : AC(55)

Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)

Quercetin, Luteolin, Chrysin, Kaempferol, Apigenin, and Myricetin exhibit cytotoxic effeccts on a human esophageal cancer cell line.

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Pubmed Data : Food Chem Toxicol. 2008 Jun;46(6):2042-53. Epub 2008 Feb 7. PMID: 18331776

Article Published Date : Jun 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Apigenin : CK(76) : AC(51), Chrysin : CK(15) : AC(12), Kaempferol : CK(27) : AC(22), Luteolin : CK(62) : AC(51), Myricetin : CK(7) : AC(6), Quercetin : CK(318) : AC(136)

Diseases : Esophageal Cancer : CK(328) : AC(55)

Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)

The dietary flavonoids luteolin, apigenin, chrysin and naringenin (found in fruits and vegetables) are potent natural proteasome inhibotrs and tumor cell death inducers.

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Pubmed Data : Front Biosci. 2007;12:1935-45. Epub 2007 Jan 1. PMID: 17127432

Article Published Date : Jan 01, 2007

Study Type : In Vitro Study

Additional Links

Substances : Apigenin : CK(76) : AC(51), Chrysin : CK(15) : AC(12), Flavonoids : CK(909) : AC(289), Fruit: All : CK(1836) : AC(472), Luteolin : CK(62) : AC(51), Naringenin : CK(17) : AC(12), Vegetables: All : CK(551) : AC(69)

Diseases : Cancers: All : CK(9062) : AC(2869), Tumors : CK(197) : AC(110)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Apoptotic : CK(1489) : AC(1114), Chemopreventive : CK(1528) : AC(382), Proteasome Inhibitors : CK(41) : AC(27)

Various carotenoids and flavonoids from plants may contribute to the reversal of multidrug resistance.

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Pubmed Data : Curr Top Med Chem. 2010;10(17):1757-68. PMID: 20645919

Article Published Date : Jan 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Antheraxanthin : CK(1) : AC(1), Capsaicin : CK(60) : AC(34), Capsorubin : CK(2) : AC(2), Carotenoids : CK(1055) : AC(213), Chrysin : CK(15) : AC(12), Flavonoids : CK(909) : AC(289), Lutein : CK(124) : AC(22), Lycopene : CK(194) : AC(38), Paprika : CK(8) : AC(6), Phloretin : CK(4) : AC(4), Sakuranetin : CK(1) : AC(1)

Diseases : Cancers: Multi-Drug Resistant : CK(92) : AC(73)

Pharmacological Actions : Chemosensitizer : CK(197) : AC(159), P-glycoprotein Inhibitors : CK(2) : AC(2)

Wogonin and chrysin may contribute to overcoming drug resistance in non-small cell lung cancer cells.

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Pubmed Data : Int J Cancer. 2007 May 1;120(9):2019-27. PMID: 17266043

Article Published Date : May 01, 2007

Study Type : In Vitro Study

Additional Links

Substances : Chrysin : CK(15) : AC(12), Flavonoids : CK(909) : AC(289), Wogonin : CK(13) : AC(9)

Diseases : Cancers: Drug Resistant : CK(225) : AC(147), Lung Cancer : CK(496) : AC(198), Non-Small-Cell Lung Carcinoma : CK(45) : AC(7)

Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319), Interleukin-6 Downregulation : CK(470) : AC(135)

Additional Keywords : Drug: Doxorubicin : CK(141) : AC(55)

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