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CLA (Conjugated Linoleic Acid)

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Article Count - 27
Cumulative Knowledge - 71

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View the Evidence: Substances

An organic diet increases the amount of beneficial CLA and trans-vaccenic acid in human breast milk.

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Pubmed Data : Br J Nutr. 2007 Apr;97(4):735-43. PMID: 17349086

Article Published Date : Apr 01, 2007

Study Type : Human Study

Additional Links

Substances : CLA (Conjugated Linoleic Acid) : CK(71) : AC(27), Vaccenic acid : CK(25) : AC(9)

Diseases : Breast Milk: Inadequate/Poor Quality : CK(60) : AC(7)

Additional Keywords : Organic Versus Conventional : CK(49) : AC(10)

Conjugated linoleic acid and safflower oil improve body composition in obese postmenopausal women with type 2 diabetes mellitus.

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Pubmed Data : Am J Clin Nutr. 2009 Sep;90(3):468-76. Epub 2009 Jun 17. PMID: 19535429

Article Published Date : Sep 01, 2009

Study Type : Human Study

Additional Links

Substances : CLA (Conjugated Linoleic Acid) : CK(71) : AC(27), Safflower : CK(14) : AC(4)

Diseases : Obesity : CK(1849) : AC(275)

Conjugated linoleic acid and vitamin E supplementation reduces inflammation in patients with active rheumatoid arthritis.

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Pubmed Data : Int J Rheum Dis. 2009 Apr;12(1):20-8. PMID: 20374312

Article Published Date : Apr 01, 2009

Study Type : Human Study

Additional Links

Substances : CLA (Conjugated Linoleic Acid) : CK(71) : AC(27), Vitamin E : CK(1285) : AC(221)

Diseases : Erythrocyte Sedimentation Rate (ESR): Elevated : CK(10) : AC(1), Rheumatoid Arthritis : CK(424) : AC(64)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

Conjugated linoleic acid combined with creatine monohydrate and whey protein supplementation improve strength and lean-tissue mass during heavy during resistance training.

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Pubmed Data : Int J Sport Nutr Exerc Metab. 2009 Feb;19(1):79-96. PMID: 19403955

Article Published Date : Feb 01, 2009

Study Type : Human Study

Additional Links

Substances : CLA (Conjugated Linoleic Acid) : CK(71) : AC(27), Creatine : CK(134) : AC(24), Whey : CK(323) : AC(72)

Diseases : Athletic Performance: Strength : CK(30) : AC(3)

Additional Keywords : Drug-Plant-Vitamin Synergies : CK(1011) : AC(268)

Bovine milk fat enriched in conjugated linoleic and vaccenic acids attenuates allergic airway disease in mice.

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Pubmed Data : Clin Exp Allergy. 2008 Jan;38(1):208-18. Epub 2007 Nov 13. PMID: 18005183

Article Published Date : Jan 01, 2008

Study Type : Animal Study

Additional Links

Substances : Butter : CK(55) : AC(13), CLA (Conjugated Linoleic Acid) : CK(71) : AC(27), Vaccenic acid : CK(25) : AC(9)

Diseases : Allergic Airway Diseases : CK(41) : AC(17), Allergies : CK(502) : AC(92)

Pharmacological Actions : Anti-Allergic Agents : CK(89) : AC(38)

Butter naturally enriched in conjugated linoleic acid and vaccenic acid alters tissue fatty acids and improves the plasma lipoprotein profile in cholesterol-fed hamsters.

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Pubmed Data : J Nutr. 2005 Aug;135(8):1934-9. PMID: 16046719

Article Published Date : Aug 01, 2005

Study Type : Animal Study

Additional Links

Substances : Butter : CK(55) : AC(13), CLA (Conjugated Linoleic Acid) : CK(71) : AC(27), Vaccenic acid : CK(25) : AC(9)

Diseases : Apolipoprotein Disorders : CK(48) : AC(9), Dyslipoproteinemias : CK(2) : AC(1)

Butter naturally enriched with conjugated linoleic acid and vaccenic acid has a beneficial effect on serum fatty acid composition in growing pigs.

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Pubmed Data : Lipids Health Dis. 2008;7:31. Epub 2008 Aug 29. PMID: 18759970

Article Published Date : Jan 01, 2008

Study Type : Animal Study

Additional Links

Substances : Butter : CK(55) : AC(13), CLA (Conjugated Linoleic Acid) : CK(71) : AC(27), Vaccenic acid : CK(25) : AC(9)

Diseases : High Cholesterol : CK(1718) : AC(198)

CLA and Omega 3 fatty acids are therapeutic in experimental inflammatory bowel disease.

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Pubmed Data : Clin Nutr.2006 Jun;25(3):454-65. Epub 2006 May 15. PMID: 16698153

Article Published Date : Jun 01, 2006

Study Type : Animal Study

Additional Links

Substances : CLA (Conjugated Linoleic Acid) : CK(71) : AC(27), Omega-3 Fatty Acids : CK(3333) : AC(319)

Diseases : Inflammatory Bowel Diseases : CK(1227) : AC(103)

CLA attenuates porcine bacterial-induced colitis.

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Pubmed Data : J Nutr. 2002 Jul;132(7):2019-27. PMID: 12097686

Article Published Date : Jul 01, 2002

Study Type : Animal Study

Additional Links

Substances : CLA (Conjugated Linoleic Acid) : CK(71) : AC(27)

Diseases : Colitis : CK(368) : AC(53)

CLA reduces gliadin-induced intestinal toxicity in an animal model.

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Pubmed Data : Mol Nutr Food Res. 2011 Sep ;55 Suppl 2:S248-56. Epub 2011 Aug 31. PMID: 21954188

Article Published Date : Sep 01, 2011

Study Type : Animal Study

Additional Links

Substances : CLA (Conjugated Linoleic Acid) : CK(71) : AC(27)

Diseases : Gastrointestinal Inflammation : CK(41) : AC(7), Gluten Intolerance : CK(236) : AC(33), Gluten Sensitivity : CK(2477) : AC(270), Wheat Intolerance : CK(2480) : AC(231)

Problem Substances : Gliadin : CK(2509) : AC(110)

Conjugated linoleic acid and chromium lower body weight and visceral fat mass in high fat fed mice.

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Pubmed Data : J Ren Nutr. 2009 Sep;19(5):389-95. Epub 2009 Jul 3. PMID: 16933788

Article Published Date : Sep 01, 2009

Study Type : Animal Study

Additional Links

Substances : Chromium : CK(46) : AC(11), CLA (Conjugated Linoleic Acid) : CK(71) : AC(27)

Diseases : Abdominal Obesity (Midsection Fat) : CK(348) : AC(53), Overweight : CK(2176) : AC(342)

Conjugated linoleic acid prevents age-associated skeletal muscle loss (sarcopenia).

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Pubmed Data : Biochem Biophys Res Commun. 2009 Jun 12;383(4):513-8. Epub 2009 Apr 22. PMID: 19393220

Article Published Date : Jun 12, 2009

Study Type : Animal Study

Additional Links

Substances : CLA (Conjugated Linoleic Acid) : CK(71) : AC(27)

Diseases : Sarcopenia : CK(29) : AC(7)

Conjugated linoleic acid prevents growth attenuation induced by corticosteroids and increases bone mineral content in young rats

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Pubmed Data : Appl Physiol Nutr Metab. 2008 Dec;33(6):1096-104. PMID: 19088767

Article Published Date : Dec 01, 2008

Study Type : Animal Study

Additional Links

Substances : CLA (Conjugated Linoleic Acid) : CK(71) : AC(27)

Diseases : Osteoporosis: Steroid-Induced : CK(28) : AC(6)

Dietary coconut oil increases conjugated linoleic acid-induced body fat loss in mice.

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Pubmed Data : Biochim Biophys Acta. 2005 Oct 15;1737(1):52-60. Epub 2005 Sep 13. PMID: 16216548

Article Published Date : Oct 15, 2005

Study Type : Animal Study

Additional Links

Substances : CLA (Conjugated Linoleic Acid) : CK(71) : AC(27), Coconut : CK(124) : AC(35), Coconut Oil : CK(95) : AC(25)

Diseases : Weight Problems : CK(2152) : AC(334)

Dietary conjugated linolenic acid reduces renal inury in a rat model of polycystic kidney disease.

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Pubmed Data : J Urol. 2007 Apr;177(4):1358-62; discussion 1362; quiz 1591. PMID: 18629561

Article Published Date : Apr 01, 2007

Study Type : Animal Study

Additional Links

Substances : CLA (Conjugated Linoleic Acid) : CK(71) : AC(27)

Diseases : Polycystic Kidney Diseases : CK(13) : AC(7)

Dietary supplementation of L-arginine and conjugated linoleic acid reduces retroperitoneal fat mass and increases lean body mass in rats.

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Pubmed Data : J Nutr. 2009 Jul;139(7):1279-85. Epub 2009 May 13. PMID: 19439462

Article Published Date : Jul 01, 2009

Study Type : Animal Study

Additional Links

Substances : Arginine : CK(970) : AC(169), CLA (Conjugated Linoleic Acid) : CK(71) : AC(27)

Diseases : Muscle Atrophy : CK(56) : AC(22), Obesity : CK(1849) : AC(275)

Pharmacological Actions : Anabolic Agents : CK(42) : AC(10), Anti-Adipogenic : CK(87) : AC(44)

White button mushroom and its major component, CLA, exhibits antiproliferative and proapoptotic properties and inhibits prostate tumor growth in athymic mice.

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Pubmed Data : Nutr Cancer. 2008;60(6):744-56. PMID: 19005974

Article Published Date : Jan 01, 2008

Study Type : Animal Study

Additional Links

Substances : CLA (Conjugated Linoleic Acid) : CK(71) : AC(27), White Button Mushroom : CK(16) : AC(11)

Diseases : Prostate Cancer : CK(998) : AC(288)

Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114)

CLA inhibits cell proliferation and increases programmed cell death in human bladder cancer cells.

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Pubmed Data : J Med Food. 2010 Feb;13(1):13-9. PMID: 20136431

Article Published Date : Feb 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : CLA (Conjugated Linoleic Acid) : CK(71) : AC(27)

Diseases : Bladder Cancer : CK(186) : AC(60)

Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Insulin-Like Growth Factor Inhibition/Downregulation : CK(66) : AC(16)

CLA inhibits the growth of human colon cancer cells via the downregulation of IGF-1 receptor levels.

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Pubmed Data : J Nutr. 2003 Aug;133(8):2675-81. PMID: 12888657

Article Published Date : Aug 01, 2003

Study Type : In Vitro Study

Additional Links

Substances : CLA (Conjugated Linoleic Acid) : CK(71) : AC(27)

Diseases : Colon Cancer : CK(895) : AC(233)

Pharmacological Actions : Insulin-Like Growth Factor Inhibition/Downregulation : CK(66) : AC(16)

Conjugated linoleic acid inhibits DNA synthesis and induces programmed cell death in human bladder cancer cells.

Click here to read the entire abstract

Pubmed Data : Anticancer Res. 2003 Nov-Dec;23(6C):4765-72. PMID: 14981924

Article Published Date : Nov 01, 2003

Study Type : In Vitro Study

Additional Links

Substances : CLA (Conjugated Linoleic Acid) : CK(71) : AC(27)

Diseases : Bladder Cancer : CK(186) : AC(60)

Pharmacological Actions : Apoptotic : CK(1489) : AC(1114)

Pomegranate seed compounds have estrogen receptor enzyme modulating activity.

Click here to read the entire abstract

Pubmed Data : Atherosclerosis. 2007 Aug;193(2):277-82. Epub 2006 Sep 29. PMID: 20136514

Article Published Date : Aug 01, 2007

Study Type : In Vitro Study

Additional Links

Substances : CLA (Conjugated Linoleic Acid) : CK(71) : AC(27), Pomegranate : CK(146) : AC(61)

Diseases : Breast Cancer : CK(2354) : AC(621)

Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Estrogen Receptor Modulators : CK(28) : AC(19), Selective estrogen enzyme modulator (SEEM) : CK(11) : AC(8), Selective Estrogen Receptor Modulators : CK(10) : AC(6)

Additional Keywords : Estrogen Receptor Beta : CK(24) : AC(11)

Vaccenic acid is a dietary precursor of conjugated linoleic acid (CLA) and may have health benefits beyond those associated with CLA.

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Pubmed Data : Medicina (Kaunas). 2007;43(8):597-606. PMID: 19935865

Article Published Date : Jan 01, 2007

Study Type : Review

Additional Links

Substances : CLA (Conjugated Linoleic Acid) : CK(71) : AC(27), Vaccenic acid : CK(25) : AC(9)

Diseases : Cardiovascular Diseases : CK(5138) : AC(641)

Additional Keywords : Substances that are Linked : CK(16) : AC(6)

CLA produces a modest loss in body fat in humans.

Click here to read the entire abstract

Pubmed Data : Am J Clin Nutr. 2007 May;85(5):1203-11. PMID: 17490954

Article Published Date : May 01, 2007

Additional Links

Substances : CLA (Conjugated Linoleic Acid) : CK(71) : AC(27)

CLA protects against fat mass regain following weight loss.

Click here to read the entire abstract

Pubmed Data : J Food Sci. 2007 Oct;72(8):S612-7. PMID: 17995628

Article Published Date : Oct 01, 2007

Additional Links

Substances : CLA (Conjugated Linoleic Acid) : CK(71) : AC(27)

CLA reduces body fat content in mice.

Click here to read the entire abstract

Pubmed Data : Cancer Biother Radiopharm. 2009 Dec;24(6):675-80. PMID: 10198400

Article Published Date : Dec 01, 2009

Additional Links

Substances : CLA (Conjugated Linoleic Acid) : CK(71) : AC(27)

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