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Article Count - 32
Cumulative Knowledge - 266

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View the Evidence: Substances

Chocolate consumption during pregnancy may reduce the likelihood of preeclampsia.

Click here to read the entire abstract

Pubmed Data : Epidemiology. 2008 May;19(3):459-64. PMID: 18379424

Article Published Date : May 01, 2008

Study Type : Meta Analysis

Additional Links

Substances : Chocolate : CK(243) : AC(32)

Diseases : Pre-Eclampsia : CK(309) : AC(33)

Chocolate consumption is associated with a substantial reduction in the risk of cardiometabolic disorders.

Click here to read the entire abstract

Pubmed Data : BMJ. 2011 ;343:d4488. Epub 2011 Aug 26. PMID: 21875885

Article Published Date : Jan 01, 2011

Study Type : Meta Analysis

Additional Links

Substances : Chocolate : CK(243) : AC(32)

Diseases : Blood Sugar Problems : CK(4280) : AC(727), Cardiovascular Diseases : CK(5138) : AC(641), Coronary Artery Disease : CK(1305) : AC(136), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Metabolic Syndrome X : CK(645) : AC(122), Stroke : CK(540) : AC(47)

Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

Meta-analysis: Chocolate, cocoa and flavan-3-ols improve insulin resistance, reduces serum insulin levels, and parameters associated with cardiovascular disease risk.

Click here to read the entire abstract

Pubmed Data : Am J Clin Nutr. 2012 Feb 1. Epub 2012 Feb 1. PMID: 22301923

Article Published Date : Feb 01, 2012

Study Type : Meta Analysis

Additional Links

Substances : Chocolate : CK(243) : AC(32), Cocoa : CK(243) : AC(32), Flavan-3-ols : CK(20) : AC(1)

Diseases : Cardiovascular Diseases : CK(5138) : AC(641), Hypertension : CK(2783) : AC(271), Insulin: Elevated : CK(186) : AC(41), Insulin Resistance : CK(1034) : AC(221)

Pharmacological Actions : Hypotensive : CK(383) : AC(53)

Chocolate consumption is inversely associated with calcified atherosclerotic plaque in the coronary arteries.

Click here to read the entire abstract

Pubmed Data : Indian J Pharmacol. 2010 Dec;42(6):334-7. PMID: 20655129

Article Published Date : Dec 01, 2010

Study Type : Human Study

Additional Links

Substances : Cocoa : CK(243) : AC(32)

Diseases : Arteriosclerosis : CK(2154) : AC(123), Calcification: Arterial : CK(10) : AC(1), Cardiovascular Diseases : CK(5138) : AC(641), Coronary Artery Disease : CK(1305) : AC(136)

Additional Keywords : Risk Reduction : CK(1909) : AC(196)

Chocolate consumption is inversely associated with prevalent coronary heart disease.

Click here to read the entire abstract

Pubmed Data : Clin Nutr. 2010 Sep 19. Epub 2010 Sep 19. PMID: 20858571

Article Published Date : Sep 19, 2010

Study Type : Human Study

Additional Links

Substances : Cocoa : CK(243) : AC(32)

Diseases : Cardiovascular Diseases : CK(5138) : AC(641), Coronary Artery Disease : CK(1305) : AC(136)

Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

Additional Keywords : Risk Reduction : CK(1909) : AC(196)

Chocolate consumption may reduce the risk of heart attack and stroke not using antihypertensive medication.

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Pubmed Data : Eur Heart J. 2010 Jul;31(13):1616-23. Epub 2010 Mar 30. PMID: 20354055

Article Published Date : Jul 01, 2010

Study Type : Human Study

Additional Links

Substances : Chocolate : CK(243) : AC(32)

Diseases : Heart Attack : CK(2598) : AC(117), Stroke : CK(540) : AC(47)

Additional Keywords : Risk Reduction : CK(1909) : AC(196)

Chocolate intake during pregnancy may reduce the risks of preeclampsia and gestational hypertension

Click here to read the entire abstract

Pubmed Data : Ann Epidemiol. 2010 Aug;20(8):584-91. PMID: 20609337

Article Published Date : Aug 01, 2010

Study Type : Human Study

Additional Links

Substances : Chocolate : CK(243) : AC(32)

Diseases : Gestational Diabetes : CK(44) : AC(6), Pre-Eclampsia : CK(309) : AC(33)

Chronic cocoa consumption improves endothelial function in postmenopausal women with high cholesterol.

Click here to read the entire abstract

Pubmed Data : Breast Cancer Res Treat. 2009 Sep;117(1):111-9. Epub 2008 Oct 18. PMID: 16794456

Article Published Date : Sep 01, 2009

Study Type : Human Study

Additional Links

Substances : Cocoa : CK(243) : AC(32)

Diseases : Endothelial Dysfunction : CK(897) : AC(173), Postmenopausal Disorders : CK(285) : AC(35)

Cocoa flavanols reverse vascular dysfunction in diabetics.

Click here to read the entire abstract

Pubmed Data : Leuk Res. 2009 Jun;33(6):823-8. Epub 2008 Nov 17. PMID: 18510961

Article Published Date : Jun 01, 2009

Study Type : Human Study

Additional Links

Substances : Cocoa : CK(243) : AC(32)

Diseases : Diabetes: Cardiovascular Illness : CK(666) : AC(104), Diabetes: Vascular Dysfunction : CK(12) : AC(1), Diabetes Mellitus: Type 1 : CK(1107) : AC(218), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Endothelial Dysfunction : CK(897) : AC(173)

Cocoa powder has a positive effect on inflammatory mediators in patients at high risk of cardiovascular disease.

Click here to read the entire abstract

Pubmed Data : Am J Clin Nutr. 2009 Nov;90(5):1144-50. Epub 2009 Sep 23. PMID: 19776136

Article Published Date : Nov 01, 2009

Study Type : Human Study

Additional Links

Substances : Cocoa : CK(243) : AC(32)

Diseases : Cardiovascular Diseases : CK(5138) : AC(641)

Pharmacological Actions : Cardiotonic Agents : CK(46) : AC(7)

Cocoa-derived flavanols are effective prebiotics as demonstrated in healthy human volunteers.

Click here to read the entire abstract

Pubmed Data : Am J Clin Nutr. 2010 Nov 10. Epub 2010 Nov 10. PMID: 21068351

Article Published Date : Nov 10, 2010

Study Type : Human Study

Additional Links

Substances : Bifidobacterium : CK(476) : AC(40), Cocoa : CK(243) : AC(32), Lactobacillus probiotics : CK(1217) : AC(142), Prebiotics : CK(114) : AC(15)

Diseases : Dysbiosis : CK(123) : AC(30)

Additional Keywords : Substances that are Linked : CK(16) : AC(6)

Daily consumption of 40 g of dark chocolate during a period of 2 weeks reduces the urinary excretion of the stress hormone cortisol and catecholamines, while reducing other metabolic indicators of stress.

Click here to read the entire abstract

Pubmed Data : J Proteome Res. 2009 Dec;8(12):5568-79. PMID: 19810704

Article Published Date : Dec 01, 2009

Study Type : Human Study

Additional Links

Substances : Chocolate : CK(243) : AC(32)

Diseases : Catecholamines: Elevated : CK(76) : AC(10), Cortisol: High : CK(841) : AC(60), Stress : CK(434) : AC(60)

Dark chocolate consumption increases HDL cholesterol concentration and chocolate fatty acids may inhibit lipid peroxidation in healthy humans.

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol.2008 Dec;46(12):3586-92. Epub 2008 Sep 3 PMID: 15454274

Article Published Date : Dec 01, 2008

Study Type : Human Study

Additional Links

Substances : Chocolate : CK(243) : AC(32), Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)

Diseases : Cholesterol: LDL/HDL ratio : CK(432) : AC(58), Cholesterol: Oxidation : CK(457) : AC(98), HDL: Low : CK(255) : AC(45)

Flavonoid-rich dark chocolate improves endothelial function and increases plasma antioxidant concentrations in healthy adults.

Click here to read the entire abstract

Pubmed Data : J Am Coll Nutr. 2004 Jun;23(3):197-204. PMID: 15190043

Article Published Date : Jun 01, 2004

Study Type : Human Study

Additional Links

Substances : Cocoa : CK(243) : AC(32), Flavonoids : CK(909) : AC(289)

Diseases : Endothelial Dysfunction : CK(897) : AC(173)

Habitual cocoa intake efficiently reduces blood pressure and improves the formation of vasodilative nitric oxide.

Click here to read the entire abstract

Pubmed Data : JAMA. 2007 Jul 4;298(1):49-60. PMID: 17609490

Article Published Date : Jul 04, 2007

Study Type : Human Study

Additional Links

Substances : Cocoa : CK(243) : AC(32)

Diseases : Hypertension : CK(2783) : AC(271)

Pharmacological Actions : Hypotensive : CK(383) : AC(53)

In patients with cirrhosis, dark chocolate blunted the postprandial increase in hepatic venous pressure gradient by improving flow-mediated hepatic vasorelaxation and ameliorated systemic hypotension.

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Pubmed Data : Am J Clin Nutr. 2012 Jul 18. Epub 2012 Jul 18. PMID: 22811444

Article Published Date : Jul 17, 2012

Study Type : Human Study

Additional Links

Substances : Chocolate : CK(243) : AC(32)

Diseases : Cirrhosis : CK(204) : AC(32), Hypertension: Portal : CK(12) : AC(2)

Pharmacological Actions : Vasodilator Agents : CK(262) : AC(54)

Regular consumption of a chocolate rich in flavanols confers significant photoprotection and can thus be effective at protecting human skin from harmful UV effects.

Click here to read the entire abstract

Pubmed Data : Lett Appl Microbiol. 2009 Sep;49(3):354-60. Epub 2009 Jul 14. PMID: 19735513

Article Published Date : Sep 01, 2009

Study Type : Human Study

Additional Links

Substances : Chocolate : CK(243) : AC(32), Flavonoids : CK(909) : AC(289)

Diseases : Skin Diseases: Photo-Aging : CK(365) : AC(47), Sunburn : CK(31) : AC(18)

Solid dark chocolate and liquid cocoa improve endothelial function and lower blood pressure in overweight adults.

Click here to read the entire abstract

Pubmed Data : Am J Clin Nutr. 2008 Jul;88(1):58-63. PMID: 18614724

Article Published Date : Jul 01, 2008

Study Type : Human Study

Additional Links

Substances : Cocoa : CK(243) : AC(32)

Diseases : Endothelial Dysfunction : CK(897) : AC(173), Hypertension : CK(2783) : AC(271)

Those with higher depression scores generally consume higher amounts of chocolate.

Click here to read the entire abstract

Pubmed Data : Arch Intern Med. 2010 Apr 26;170(8):699-703. PMID: 20421555

Article Published Date : Apr 26, 2010

Study Type : Human Study

Additional Links

Substances : Cocoa : CK(243) : AC(32)

Diseases : Depression : CK(674) : AC(88)

Additional Keywords : Food-Mood Correlation : CK(10) : AC(1)

A cocoa-enriched diet prevents gingival oxidative stress in experimental periodontitis.

Click here to read the entire abstract

Pubmed Data : J Periodontol. 2009 Nov;80(11):1799-808. PMID: 19905949

Article Published Date : Nov 01, 2009

Study Type : Animal Study

Additional Links

Substances : Cocoa : CK(243) : AC(32), Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)

Diseases : Periodontitis : CK(61) : AC(14)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Cacoa seeds have anti-lymphoma properties.

Click here to read the entire abstract

Pubmed Data : BMC Complement Altern Med. 2010;10:61. Epub 2010 Oct 20. PMID: 20961452

Article Published Date : Jan 01, 2010

Study Type : Animal Study

Additional Links

Substances : Cocoa : CK(243) : AC(32)

Diseases : Lymphoma : CK(209) : AC(69)

Cocoa polyphenols prevent lung cancer in rats.

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2010 Jan 18. Epub 2010 Jan 18. PMID: 12609709

Article Published Date : Jan 18, 2010

Study Type : Animal Study

Additional Links

Substances : Cocoa : CK(243) : AC(32)

Diseases : Lung Cancer : CK(496) : AC(198)

Cocoa polyphenols prevent testosterone-induced hyperplasia in a rat model of benign prostatic hyperplasia.

Click here to read the entire abstract

Pubmed Data : J Med Food. 2007 Dec;10(4):622-7. PMID: 18158832

Article Published Date : Dec 01, 2007

Study Type : Animal Study

Additional Links

Substances : Cocoa : CK(243) : AC(32)

Diseases : Androgen-Induced Diseases : CK(49) : AC(20), Prostatic Hyperplasia: Benign : CK(202) : AC(46), Testosterone-Induced : CK(5) : AC(3)

Cocoa polyphenols protect rats from prostate carcinogenesis.

Click here to read the entire abstract

Pubmed Data : Eur J Cancer Prev. 2008 Feb;17(1):54-61. PMID: 18090911

Article Published Date : Feb 01, 2008

Study Type : Animal Study

Additional Links

Substances : Cocoa : CK(243) : AC(32)

Diseases : Prostate Cancer : CK(998) : AC(288)

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