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Coenzyme Q10

Coenzyme Q10

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Article Count - 104
Cumulative Knowledge - 741

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View the Evidence: Substances

Coenzyme Q10 has a protective effect in an experimental model of myocardial injury.

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Pubmed Data : Kardiologiia. 2004;44(1):43-7. PMID: 15029148

Article Published Date : Jan 01, 2004

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10 : CK(667) : AC(104)

Diseases : Myocardial Infarction : CK(2632) : AC(117), Myocardial Ischemia : CK(87) : AC(37), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

Coenzyme q10 has positive effects on diabetic neuropathy in rats.

Click here to read the entire abstract

Pubmed Data : Methods Find Exp Clin Pharmacol. 2008 Jun;30(5):367-74. PMID: 18806896

Article Published Date : Jun 01, 2008

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10 : CK(667) : AC(104)

Diseases : Diabetic Neuropathies : CK(203) : AC(32)

Coenzyme Q10 has therapeutic value as demonstrated in a transgenic animal model of Alzheimer's disease.

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Pubmed Data : J Alzheimers Dis. 2011 Jul 28. Epub 2011 Jul 28. PMID: 21799249

Article Published Date : Jul 28, 2011

Study Type : Transgenic Animal Study

Additional Links

Substances : Coenzyme Q10 : CK(667) : AC(104)

Diseases : Alzheimer's Disease : CK(826) : AC(160)

Pharmacological Actions : Neuroprotective Agents : CK(962) : AC(480)

Coenzyme Q10 may have profound and beneficial effects in treatment of certain forms of focal segmental glomerulosclerosis.

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Pubmed Data : Am J Physiol Renal Physiol. 2008 Nov;295(5):F1535-44. Epub 2008 Sep 10. PMID: 18784258

Article Published Date : Nov 01, 2008

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10 : CK(667) : AC(104)

Diseases : Glomerulosclerosis : CK(8) : AC(5)

Coenzyme Q10 prevents noise-induced hearing loss in a guinea pig model.

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Pubmed Data : Brain Res. 2009 Feb 27;1257:108-16. Epub 2008 Dec 24. PMID: 19133240

Article Published Date : Feb 27, 2009

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10 : CK(667) : AC(104)

Diseases : Hearing Loss: Noise-Induced : CK(36) : AC(10)

Pharmacological Actions : Apoptotic : CK(1489) : AC(1114)

Coenzyme Q10 prevents paraquat-induced oxidative stress, neuronal loss in substantia nigra region and parkinsonism in adult rats.

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Pubmed Data : BMC Neurosci. 2009;10:88. Epub 2009 Jul 27. PMID: 19635141

Article Published Date : Jan 01, 2009

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10 : CK(667) : AC(104)

Diseases : Oxidative Stress : CK(1945) : AC(710), Parkinson Disease : CK(543) : AC(79), Parkinsonian Disorders : CK(15) : AC(4)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Neuroprotective Agents : CK(962) : AC(480)

Coenzyme Q10 protects against sodium nitrate-induced lipid peroxidation in rats.

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Pubmed Data : Rocz Panstw Zakl Hig. 2001;52(3):213-8. PMID: 11771113

Article Published Date : Jan 01, 2001

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10 : CK(667) : AC(104)

Diseases : Sodium nitrate toxicity : CK(15) : AC(8)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

Coenzyme Q10 reduces beta-amyloid plaque in an APP/PS1 transgenic mouse model of Alzheimer's disease.

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Pubmed Data : J Mol Neurosci. 2010 May;41(1):110-3. Epub 2009 Oct 16. PMID: 19834824

Article Published Date : May 01, 2010

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10 : CK(667) : AC(104)

Diseases : Alzheimer's Disease : CK(826) : AC(160)

Pharmacological Actions : Neuroprotective Agents : CK(962) : AC(480)

Coenzyme q10 reduces high fructose feeding induced hepatic stress.

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Pubmed Data : Biochem Pharmacol. 2009 Jul 23. PMID: 19632207

Article Published Date : Jul 23, 2009

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10 : CK(667) : AC(104)

Diseases : Liver Stress: Fructose-Induced : CK(19) : AC(10)

Additional Keywords : Fructose-Induced Insulin Resistance : CK(36) : AC(10)

Coenzyme Q10 treatment ameliorates acute cisplatin nephrotoxicity in mice.

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Pubmed Data : Toxicology. 2010 Jul-Aug;274(1-3):49-56. Epub 2010 May 25. PMID: 20510337

Article Published Date : Jul 01, 2010

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10 : CK(667) : AC(104)

Diseases : Chemotherapy-Induced Toxicity : CK(704) : AC(184), Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Combination therapy using CoQ(10) and creatine may be useful in the treatment of neurodegenerative diseases such as Parkinson's disease and Huntington Disease.

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Pubmed Data : J Neurochem. 2009 Jun;109(5):1427-39. Epub 2009 Mar 28. PMID: 19476553

Article Published Date : Jun 01, 2009

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10 : CK(667) : AC(104), Creatine : CK(134) : AC(24)

Diseases : Huntington Disease : CK(45) : AC(17), Parkinson Disease : CK(543) : AC(79)

Pharmacological Actions : Neuroprotective Agents : CK(962) : AC(480)

Additional Keywords : Natural Substance Synergy : CK(144) : AC(81)

CoQ10 has a beneficial effect in reducing ascites mortality in broilers.

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Pubmed Data : Poult Sci. 2004 Sep;83(9):1587-93. PMID: 15384911

Article Published Date : Sep 01, 2004

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10 : CK(667) : AC(104)

Diseases : Ascites : CK(97) : AC(18)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

CoQ10 supplementation reduces broiler chickens' susceptibility to ascites through improving mitochondrial function.

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Pubmed Data : Angiology. 2003 Sep-Oct;54(5):531-9. PMID: 16359119

Article Published Date : Sep 01, 2003

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10 : CK(667) : AC(104)

Diseases : Ascites : CK(97) : AC(18), Lipopolysaccharide-Induced Toxicity : CK(227) : AC(128)

CoQ10 supplementation reduces exhaustive exercise-induced muscular injury by enhancing stabilization of muscle cell membrane.

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Pubmed Data : Exerc Immunol Rev. 2007;13:76-88. PMID: 18198662

Article Published Date : Jan 01, 2007

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10 : CK(667) : AC(104)

Diseases : Exercise-Induced Tissue Damage : CK(40) : AC(8), Muscle Soreness: Exercise-Induced : CK(114) : AC(13)

CoQ10, omega-3 and propionyl-L-carnitine may provide an effective adjuvant to conventional therapy in dilated cardiomyopathy.

Click here to read the entire abstract

Pubmed Data : Biofactors. 2008;32(1-4):135-44. PMID: 19096109

Article Published Date : Jan 01, 2008

Study Type : Animal Study

Additional Links

Substances : Carnitine: propionyl-L-carnitine : CK(62) : AC(7), Coenzyme Q10 : CK(667) : AC(104), Omega-3 Fatty Acids : CK(3333) : AC(319)

Diseases : Cardiomyopathy: Dilated : CK(2) : AC(1)

L-carnitine and CoQ10 supplementation reduce ascites mortality of broilers.

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Pubmed Data : Arch Anim Nutr. 2004 Dec;58(6):473-82. PMID: 15732580

Article Published Date : Dec 01, 2004

Study Type : Animal Study

Additional Links

Substances : Carnitine : CK(672) : AC(69), Coenzyme Q10 : CK(667) : AC(104)

Diseases : Ascites : CK(97) : AC(18)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

Neuronal degenerative findings and the secondary brain damage and ischemia caused by oxidative stress are decreased by CoQ10 use in rats with traumatic brain injury.

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Pubmed Data : BMC Neurosci. 2011 ;12:75. Epub 2011 Jul 29. PMID: 21801363

Article Published Date : Jan 01, 2011

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10 : CK(667) : AC(104)

Diseases : Brain Damage : CK(89) : AC(41), Brain Ischemia : CK(94) : AC(38), Traumatic Brain Injury : CK(33) : AC(9)

Pharmacological Actions : Neuroprotective Agents : CK(962) : AC(480)

The reduced form of coenzyme Q10 (ubiquinol) decreases aging in middle-aged mice.

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Pubmed Data : Exp Gerontol. 2006 Feb;41(2):130-40. Epub 2006 Jan 4. PMID: 16387461

Article Published Date : Feb 01, 2006

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10 : CK(667) : AC(104)

Diseases : Aging : CK(1351) : AC(369)

The reduced form of coenzyme Q10 (ubiquinol) has distinctly different effects on cholesterol metabolism than oxidized coenzyme Q10 (ubiquinone)

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Pubmed Data : IUBMB Life. 2010 Nov 17. Epub 2010 Nov 17. PMID: 21086475

Article Published Date : Nov 17, 2010

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10 : CK(667) : AC(104), Ubiquinol : CK(106) : AC(20)

Additional Keywords : Nutrient Differences: Reduced/Oxidized Forms : CK(5) : AC(3)

The reduced form of coenzyme Q10 (ubiquinol) is more effective at decelerating aging than the oxidized form (ubiquinone).

Click here to read the entire abstract

Pubmed Data : Mol Nutr Food Res. 2010 Jun;54(6):805-15. PMID: 19960455

Article Published Date : Jun 01, 2010

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10 : CK(667) : AC(104), Ubiquinol : CK(106) : AC(20)

Diseases : Aging : CK(1351) : AC(369)

Additional Keywords : Bioavailability : CK(5) : AC(3), Nutrient Differences: Reduced/Oxidized Forms : CK(5) : AC(3)

The reduced form of coenzyme Q10 may prevent or minimize cyclosporine nephrotoxicity by an antioxidant effect.

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Pubmed Data : Exp Clin Transplant. 2012 Nov 28. Epub 2012 Nov 28. PMID: 23194328

Article Published Date : Nov 27, 2012

Study Type : Animal Study

Additional Links

Substances : Ubiquinol : CK(106) : AC(20)

Diseases : Nephropathy : CK(164) : AC(31)

Pharmacological Actions : Renoprotective : CK(191) : AC(90)

Problem Substances : Cyclosporine : CK(2) : AC(0)

Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

Ubiquinol, the reduced form of CoQ10, effectively ameliorates renal function.

Click here to read the entire abstract

Pubmed Data : Clin Exp Nephrol. 2010 Sep 28. Epub 2010 Sep 28. PMID: 20878200

Article Published Date : Sep 28, 2010

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10 : CK(667) : AC(104), Ubiquinol : CK(106) : AC(20)

Diseases : Kidney Diseases : CK(424) : AC(71)

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