Daidzein

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View the Evidence: Substances

Daidzein-rich isoflavone are effective in reducing hot flashes in menopausal women.

Pubmed Data : Life Sci. 2007 Apr 24;80(20):1821-31. Epub 2007 Feb 3. PMID: 18257146
Article Published Date : Apr 24, 2007
Study Type : Human Study
Additional Links
Substances : Daidzein : CK(965) : AC(28), Isoflavones : CK(627) : AC(124)
Diseases : Hot Flash : CK(203) : AC(19), Menopausal Syndrome : CK(171) : AC(27)

Fermented soy therapy may have therapeutic value in treating platinum-resistant ovarian cancer.

Pubmed Data : Gynecol Oncol. 2006 Jan;100(1):205-9. Epub 2005 Sep 19. PMID: 16171852
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Substances : Daidzein : CK(965) : AC(28), Genistein : CK(450) : AC(174), Isoflavones : CK(627) : AC(124), Soy : CK(1672) : AC(347)
Diseases : Cancers: Drug Resistant : CK(225) : AC(147), Ovarian Cancer : CK(154) : AC(58)
Additional Keywords : Drug: Doxorubicin : CK(141) : AC(55)

Genistein and daidzein consumption are associated with a lower risk of prostate cancer.

Pubmed Data : J Altern Complement Med. 2009 Aug;15(8):905-9. PMID: 19838933
Article Published Date : Aug 01, 2009
Study Type : Human Study
Additional Links
Substances : Daidzein : CK(965) : AC(28), Genistein : CK(450) : AC(174), Isoflavones : CK(627) : AC(124)
Diseases : Prostate Cancer: Prevention : CK(155) : AC(16)
Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Chemopreventive : CK(1528) : AC(382)
Additional Keywords : Risk Reduction : CK(1909) : AC(196)

Isoflavone supplementation improves menopausal symptoms only in women with the ability to produce equol.

Pubmed Data : Int J Gynaecol Obstet. 2008 Jul;102(1):44-9. Epub 2008 Apr 8. PMID: 18395723
Article Published Date : Jul 01, 2008
Study Type : Human Study
Additional Links
Substances : Daidzein : CK(965) : AC(28), Equol : CK(33) : AC(10), Isoflavones : CK(627) : AC(124)
Diseases : Menopausal Syndrome : CK(171) : AC(27)

Soy isoflavones consumed at levels comparable to those in Asian populations may reduce the risk of cancer recurrence in women receiving tamoxifen therapy and moreover, appears not to interfere with tamoxifen efficacy.

Pubmed Data : Breast Cancer Res Treat. 2009 Nov;118(2):395-405. Epub 2009 Feb 17. PMID: 19221874
Article Published Date : Nov 01, 2009
Study Type : Human Study
Additional Links
Substances : Daidzein : CK(965) : AC(28), Isoflavones : CK(627) : AC(124)
Diseases : Breast Cancer : CK(2354) : AC(621)
Additional Keywords : Risk Reduction : CK(1909) : AC(196)

Soy isoflavones may benefit some patients with prostate cancer.

Pubmed Data : Nutr Cancer. 2003;47(2):111-7. PMID: 15087261
Article Published Date : Jan 01, 2003
Study Type : Human Study
Additional Links
Substances : Daidzein : CK(965) : AC(28), Genistein : CK(450) : AC(174), Isoflavones : CK(627) : AC(124), Soy : CK(1672) : AC(347)
Diseases : Prostate Cancer : CK(998) : AC(288)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Apoptotic : CK(1489) : AC(1114)

Soy protein reduces cholesterol oxidation in patients on hemodialysis.

Pubmed Data : J Med Food. 2006;9(3):368-72. PMID: 17004900
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Substances : Daidzein : CK(965) : AC(28), Genistein : CK(450) : AC(174), Isoflavones : CK(627) : AC(124), Soy Protein : CK(2307) : AC(56)
Diseases : Cholesterol: Oxidation : CK(457) : AC(98), Hemodialysis : CK(393) : AC(38)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

There is a modest inverse association between lignan excretion and uterine fibroid risk.

Pubmed Data : Cytotechnology. 2005 Jan;47(1-3):97-105. PMID: 16960173
Article Published Date : Jan 01, 2005
Study Type : Human Study
Additional Links
Substances : Daidzein : CK(965) : AC(28), Enterodiol : CK(34) : AC(12), Enterolactone : CK(301) : AC(10), Equol : CK(33) : AC(10), Genistein : CK(450) : AC(174), Isoflavones : CK(627) : AC(124), Lignans : CK(110) : AC(31)
Diseases : Fibroids: Uterine : CK(46) : AC(16)

Coffee contains the isoflavones genistein, daidzein and formononetin.

Pubmed Data : J Agric Food Chem. 2010 Mar 10;58(5):3002-7. PMID: 20131840
Article Published Date : Mar 10, 2010
Study Type : Animal Study
Additional Links
Substances : Coffee : CK(412) : AC(58), Daidzein : CK(965) : AC(28), Genistein : CK(450) : AC(174), Isoflavones : CK(627) : AC(124)
Additional Keywords : Substances that are Linked : CK(16) : AC(6)

Dietary soy protein isolate attenuates metabolic syndrome in rats.

Pubmed Data : J Nutr. 2009 Aug;139(8):1431-8. Epub 2009 Jun 10. PMID: 19515742
Article Published Date : Aug 01, 2009
Study Type : Animal Study
Additional Links
Substances : Daidzein : CK(965) : AC(28), Genistein : CK(450) : AC(174), Isoflavones : CK(627) : AC(124), Soy Protein : CK(2307) : AC(56)
Diseases : Fatty Liver : CK(493) : AC(122), High Cholesterol : CK(1718) : AC(198), Insulin Resistance : CK(1034) : AC(221), Metabolic Syndrome X : CK(645) : AC(122)
Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)

Phytoestrogens can stimulate testosterone synthesis during puberty in male goats by increasing the secretion of T3; a hormone known to stimulate Leydig cell steroidogenesis.

Pubmed Data : Acta Vet Scand. 2009 Dec 10;51:51. PMID: 20003293
Article Published Date : Dec 10, 2009
Study Type : Animal Study
Additional Links
Substances : Biochanin A : CK(9) : AC(8), Daidzein : CK(965) : AC(28), Formononetin : CK(2) : AC(1), Genistein : CK(450) : AC(174), phytoestrogens : CK(699) : AC(210)
Diseases : Hypothyroidism : CK(537) : AC(78), Low Testosterone : CK(385) : AC(70)
Pharmacological Actions : Secretagogue : CK(158) : AC(36), Steroidogenesis : CK(3) : AC(2)

Soy has an anti-inflammatory effect on experimentally-induced prostatitis in rats.

Pubmed Data : Exp Biol Med (Maywood). 2007 May;232(5):674-81. PMID: 17463164
Article Published Date : May 01, 2007
Study Type : Animal Study
Additional Links
Substances : Daidzein : CK(965) : AC(28), Genistein : CK(450) : AC(174), Isoflavones : CK(627) : AC(124), Soy Protein : CK(2307) : AC(56)
Diseases : Prostatitis: Acute : CK(3) : AC(2), Prostatitis: Chronic : CK(327) : AC(11)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433)

Soy phytochemicals prevent growth and metastasis of bladder cancer in mice.

Pubmed Data : Cancer Res. 2006 Feb 1;66(3):1851-8. PMID: 16452247
Article Published Date : Feb 01, 2006
Study Type : Animal Study
Additional Links
Substances : Daidzein : CK(965) : AC(28), Genistein : CK(450) : AC(174), Isoflavones : CK(627) : AC(124)
Diseases : Bladder Cancer : CK(186) : AC(60)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319), Insulin-Like Growth Factor Inhibition/Downregulation : CK(66) : AC(16), NF-kappaB Inhibitor : CK(595) : AC(401)

Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice.

Pubmed Data : J Nutr. 1999 Sep;129(9):1628-35. PMID: 10460196
Article Published Date : Sep 01, 1999
Study Type : Animal Study
Additional Links
Substances : Daidzein : CK(965) : AC(28), Genistein : CK(450) : AC(174), Soy Protein : CK(2307) : AC(56)
Diseases : Prostate Cancer : CK(998) : AC(288)
Pharmacological Actions : Angiogenesis Inhibitors : CK(6) : AC(3), Antineoplastic Agents : CK(877) : AC(496), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)

The isoflavone daidzein reduces food intake, weight gain and reduces fat content in the livers of animals on an obesity-generating diet.

Pubmed Data : Br J Pharmacol. 2011 May 10. Epub 2011 May 10. PMID: 21557739
Article Published Date : May 10, 2011
Study Type : Animal Study
Additional Links
Substances : Daidzein : CK(965) : AC(28), Isoflavones : CK(627) : AC(124)
Diseases : Fatty Liver : CK(493) : AC(122), Obesity : CK(1849) : AC(275)
Pharmacological Actions : Stearoyl coenzyme A desaturase-1 modulator : CK(2) : AC(1)

Daidzein has antiproliferative effects on human estrogren-receptor-positive and negative pancreatic cancer cells.

Pubmed Data : World J Gastroenterol. 2004 Mar 15;10(6):860-3. PMID: 15040033
Article Published Date : Mar 15, 2004
Study Type : In Vitro Study
Additional Links
Substances : Daidzein : CK(965) : AC(28)
Diseases : Pancreatic Cancer : CK(530) : AC(168)

Daidzein has neuritogenic properties.

Pubmed Data : J Biomed Sci. 2012 Aug 29 ;19(1):80. Epub 2012 Aug 29. PMID: 22931352
Article Published Date : Aug 28, 2012
Study Type : In Vitro Study
Additional Links
Substances : Daidzein : CK(965) : AC(28)
Pharmacological Actions : Neuritogenic : CK(98) : AC(48)

Daidzein may have therapeutic value in the treatment of spinal cord injury, optic nerve injury and/or stroke.

Pubmed Data : J Neurosci. 2010 Jan 13;30(2):739-48. PMID: 20071539
Article Published Date : Jan 13, 2010
Study Type : In Vitro Study
Additional Links
Substances : Daidzein : CK(965) : AC(28), Isoflavones : CK(627) : AC(124)
Diseases : Optic Nerve Diseases : CK(5) : AC(3), Spinal Cord Injuries : CK(98) : AC(28), Stroke : CK(540) : AC(47)
Pharmacological Actions : Arginase 1 (Arg1) up-regulation : CK(1) : AC(1), Enzyme Inhibitors : CK(372) : AC(208), Neuroprotective Agents : CK(962) : AC(480)

Genistein and daidzein, in combination, protect against chemically-induced mammary carcinogenesis.

Pubmed Data : Afr J Tradit Complement Altern Med. 2011 ;8(2):91-7. Epub 2010 Dec 30. PMID: 22238489
Article Published Date : Jan 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Daidzein : CK(965) : AC(28), Genistein : CK(450) : AC(174)
Diseases : Breast Cancer: Chemically-Induced : CK(5) : AC(3)
Pharmacological Actions : Chemopreventive : CK(1528) : AC(382)

Isoflavonoids and peptides from meju, long-term fermented soybeans, increase insulin sensitivity and exert insulinotropic effects in vitro.

Pubmed Data : Nutrition. 2011 Feb;27(2):244-52. Epub 2010 Jun 11. PMID: 20541368
Article Published Date : Feb 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Daidzein : CK(965) : AC(28), Genistein : CK(450) : AC(174), Isoflavones : CK(627) : AC(124), Soy : CK(1672) : AC(347), Soy: Fermented : CK(97) : AC(24)
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Insulin Resistance : CK(1034) : AC(221), Metabolic Syndrome X : CK(645) : AC(122)
Pharmacological Actions : Glucagon Like peptide 1 (GLP-1) Up-regulation : CK(118) : AC(30), Hypoglycemic Agents : CK(563) : AC(156), Insulinotrophic : CK(11) : AC(7)

Kudzu (P. radix) isoflavones and their metabolites inhibit growth and induces cell death in breast cancer cells.

Pubmed Data : Biochem Biophys Res Commun. 2009 Jan 23;378(4):683-8. Epub 2008 Nov 14. PMID: 19013426
Article Published Date : Jan 23, 2009
Study Type : In Vitro Study
Additional Links
Substances : Daidzein : CK(965) : AC(28), Genistein : CK(450) : AC(174), Isoflavones : CK(627) : AC(124), Kudzu : CK(41) : AC(11)
Diseases : Breast Cancer : CK(2354) : AC(621)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114)

Soy isoflavones can inhibit bladder tumor growth through a combination of direct effects on tumor cells and indirect effects on the tumor neovasculature.

Pubmed Data : Cancer Res. 1998 Nov 15;58(22):5231-8. PMID: 9823337
Article Published Date : Nov 15, 1998
Study Type : In Vitro Study
Additional Links
Substances : Daidzein : CK(965) : AC(28), Genistein : CK(450) : AC(174), Isoflavones : CK(627) : AC(124)
Diseases : Bladder Cancer : CK(186) : AC(60)
Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)

Soy isoflavones may protect against colon cancer.

Pubmed Data : Nutr Cancer. 2011 Jan;63(1):139-50. PMID: 21161820
Article Published Date : Jan 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Daidzein : CK(965) : AC(28), Genistein : CK(450) : AC(174), Glycitein : CK(1) : AC(1), Isoflavones : CK(627) : AC(124), Soy : CK(1672) : AC(347)
Diseases : Colon Cancer : CK(895) : AC(233)
Pharmacological Actions : Cell cycle arrest : CK(390) : AC(319)

Soybean foods may have chemotherapeutic value in the treatment of human urinary tract cancer.

Pubmed Data : Clin Cancer Res. 2000 Jan;6(1):230-6. PMID: 10656454
Article Published Date : Jan 01, 2000
Study Type : Review
Additional Links
Substances : Daidzein : CK(965) : AC(28), Genistein : CK(450) : AC(174), Isoflavones : CK(627) : AC(124), Soy : CK(1672) : AC(347)
Diseases : Bladder Cancer : CK(186) : AC(60), Urinary Tract Cancer : CK(22) : AC(4)
Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Antiproliferative : CK(1052) : AC(775), Cell cycle arrest : CK(390) : AC(319)

The isoflavone content of soybeans increases during germination.

Pubmed Data : Plant Foods Hum Nutr. 2005 Sep;60(3):147-51. PMID: 16187018
Article Published Date : Sep 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Daidzein : CK(965) : AC(28), Genistein : CK(450) : AC(174), Isoflavones : CK(627) : AC(124), Sprouts : CK(76) : AC(36)

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