DHA (Docosahexaenoic Acid)

DHA (Docosahexaenoic Acid)

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Quick Summary: Current access displays 2 out of 104 associated Diseases

Name	Cumulative Knowledge	Article Count	Focus Articles
Bipolar Disorder	50	5	Log in \| Sign up
Retinitis Pigmentosa	40	4	Log in \| Sign up

Quick Summary: Current access displays 2 out of 25 associated Pharmacological Actions

Name	Cumulative Knowledge	Article Count	Focus Articles
Tumor Necrosis Factor (TNF) Alpha Inhibitor	30	3	Log in \| Sign up
Interleukin-1 beta downregulation	20	2	Log in \| Sign up

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View the Evidence: Substances

Higher plasma concentrations of EPA and DPA are associated with a lower risk of nonfatal myocardial infarction among women.

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Pubmed Data : Am J Clin Nutr. 2008 Jul;88(1):216-23. PMID: 18614744

Article Published Date : Jul 01, 2008

Study Type : Meta Analysis

Additional Links

Substances : DHA (Docosahexaenoic Acid) : CK(562) : AC(100), EPA (Eicosapentaenoic Acid) : CK(575) : AC(84), Fish Oil : CK(613) : AC(94), Omega-3 Fatty Acids : CK(3255) : AC(319)

Diseases : Myocardial Infarction : CK(2598) : AC(117), Myocardial Infarction: Prevention : CK(42) : AC(3)

A "very low dose" of omega-3 fatty acids slows renal progression in high-risk patients with IgA nephropathy.

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Pubmed Data : Ren Fail. 2004 Jul;26(4):453-9. PMID: 15462115

Article Published Date : Jul 01, 2004

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid) : CK(562) : AC(100), EPA (Eicosapentaenoic Acid) : CK(575) : AC(84), Omega-3 Fatty Acids : CK(3255) : AC(319)

Diseases : IgA Nephropathy : CK(186) : AC(22)

Pharmacological Actions : Renoprotective : CK(185) : AC(87)

A 12-month therapy with omega-3 fatty acids improves renal vascular function and tubule function in IgA nephropathy patients.

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Pubmed Data : Am J Nephrol. 2004 Sep-Oct;24(5):474-82. Epub 2004 Sep 1. PMID: 15340256

Article Published Date : Sep 01, 2004

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid) : CK(562) : AC(100), EPA (Eicosapentaenoic Acid) : CK(575) : AC(84), Omega-3 Fatty Acids : CK(3255) : AC(319)

Pharmacological Actions : Renoprotective : CK(185) : AC(87)

A deficiency of omega-3 fatty acids may play a role in the pathophysiology of bipolar disorder in children and adolescents.

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Pubmed Data : Lipids. 2008 Nov;43(11):1031-8. Epub 2008 Sep 10. PMID: 18781353

Article Published Date : Nov 01, 2008

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid) : CK(562) : AC(100), EPA (Eicosapentaenoic Acid) : CK(575) : AC(84), Omega-3 Fatty Acids : CK(3255) : AC(319)

Diseases : Bipolar Disorder : CK(157) : AC(18)

A moderate intake of EPA and DHA may postpone cognitive decline in elderly men.

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Pubmed Data : Am J Clin Nutr. 2007 Apr;85(4):1142-7. PMID: 17413117

Article Published Date : Apr 01, 2007

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid) : CK(562) : AC(100), EPA (Eicosapentaenoic Acid) : CK(575) : AC(84), Omega-3 Fatty Acids : CK(3255) : AC(319)

Diseases : Cognitive Decline/Dysfunction : CK(514) : AC(87), Elderly: Age Specific Diseases : CK(423) : AC(37)

Pharmacological Actions : Neuroprotective Agents : CK(921) : AC(464)

Additional Keywords : Risk Reduction : CK(1943) : AC(195)

An 8-month treatment with omega-3 fatty acids (EPA and DHA) has a positive effects, such as decreasing inflammation, in patients with cystic fibrosis.

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Pubmed Data : JPEN J Parenter Enteral Nutr. 2003 Jan-Feb;27(1):52-7. PMID: 12549599

Article Published Date : Jan 01, 2003

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid) : CK(562) : AC(100), EPA (Eicosapentaenoic Acid) : CK(575) : AC(84)

Diseases : Cystic Fibrosis : CK(703) : AC(77)

An increased concentration of omega-3 fatty acids in serum (especially DHA), a marker of fish or fish oil consumption, may protect against atrial fibrillation in men.

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Pubmed Data : Circulation. 2009 Dec 8;120(23):2315-21. Epub 2009 Nov 23. PMID: 19933935

Article Published Date : Dec 08, 2009

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid) : CK(562) : AC(100), Fish Oil : CK(613) : AC(94)

Diseases : Atrial Fibrillation : CK(441) : AC(45)

Both lower DHA content in mothers' milk and lower seafood consumption were associated with higher rates of postpartum depression.

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Pubmed Data : J Affect Disord. 2002 May;69(1-3):15-29. PMID: 12103448

Article Published Date : May 01, 2002

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid) : CK(562) : AC(100), Fish Oil : CK(613) : AC(94)

Diseases : Postpartum Depression : CK(211) : AC(24)

Breastfeeding protects against illness-induced anorexia and is mediated partially by docosahexaenoic acid.

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Pubmed Data : Eur J Clin Nutr. 2008 Jan;62(1):32-8. Epub 2007 Feb 21. PMID: 17311056

Article Published Date : Jan 01, 2008

Study Type : Human Study

Additional Links

Substances : Breast Milk : CK(408) : AC(46), DHA (Docosahexaenoic Acid) : CK(562) : AC(100)

Diseases : Anorexia: Illness and Vaccine Induced : CK(10) : AC(1), Vaccine-induced Toxicity : CK(1086) : AC(163)

Therapeutic Actions : Breastfeeding : CK(657) : AC(67)

Pharmacological Actions : Interleukin-1 beta downregulation : CK(177) : AC(70), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1015) : AC(343)

Children who were not breastfed or were fed infant formula without docosahexaenoic acid/arachidonic acid supplementation were significantly more likely to have autistic disorder.

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Pubmed Data : Int Breastfeed J. 2006;1:16. Epub 2006 Sep 15. PMID: 16978397

Article Published Date : Jan 01, 2006

Study Type : Human Study

Additional Links

Substances : Breast Milk : CK(408) : AC(46), DHA (Docosahexaenoic Acid) : CK(562) : AC(100)

Diseases : Autism : CK(1340) : AC(65), Autism Spectrum Disorders : CK(1118) : AC(108)

Therapeutic Actions : Breastfeeding : CK(657) : AC(67)

Data support pro- and anti-inflammatory roles within EFA metabolism

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Pubmed Data : Prostaglandins Leukot Essent Fatty Acids. 1998 Oct ;59(4):239-45. PMID: 9849649

Article Published Date : Sep 30, 1998

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid) : CK(562) : AC(100), Essential Fatty Acids : CK(88) : AC(12)

Diseases : Sjogren's Syndrome : CK(81) : AC(14)

Pharmacological Actions : Anti-Inflammatory Agents : CK(1144) : AC(420)

Additional Keywords : cell membranes, essential fatty acids, sjogrens syndrome

DHA (Docosahexaenoic Acid) significantly enhances the activity of neutrophils and monocytes.

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Pubmed Data : Clin Nutr. 2006 Dec;25(6):923-38. Epub 2006 May 11. PMID: 16697494

Article Published Date : Dec 01, 2006

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid) : CK(562) : AC(100)

Diseases : Neutropenia : CK(90) : AC(22), Neutropenia: Chemotherapy Induced : CK(82) : AC(17), Neutropenia: Cyclic : CK(48) : AC(16), Neutropenia: Severe Congenital : CK(16) : AC(7)

DHA appears to be a conditional essential substrate for children with PKU, significantlty improving coutcomes in a test of motor function and coordination.

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Pubmed Data : J Pediatr Gastroenterol Nutr. 2009 Mar;48 Suppl 1:S2-7. PMID: 19214054

Article Published Date : Mar 01, 2009

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid) : CK(562) : AC(100), Omega-3 Fatty Acids : CK(3255) : AC(319)

Diseases : Phenylketonurias : CK(40) : AC(4)

DHA intake during pregnancy and postpartum may reduce depressive symptoms.

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Pubmed Data : Prostaglandins Leukot Essent Fatty Acids. 2003 Oct;69(4):237-43. PMID: 12907133

Article Published Date : Oct 01, 2003

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid) : CK(562) : AC(100), Omega-3 Fatty Acids : CK(3255) : AC(319)

Diseases : Postpartum Depression : CK(211) : AC(24)

DHA may have antiadhesion effects.

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Pubmed Data : Fertil Steril. 2007 Dec;88(6):1657-62. Epub 2007 May 4. PMID: 17482172

Article Published Date : Dec 01, 2007

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid) : CK(562) : AC(100)

Diseases : Abdominal Adhesions : CK(48) : AC(9)

DHA supplementation reduces the production of inflammatory mediators and decreases the adverse effect of infection on appetite.

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Pubmed Data : Rev Med Inst Mex Seguro Soc. 2006 Jan-Feb;44(1):5-11. PMID: 116497254

Article Published Date : Jan 01, 2006

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid) : CK(562) : AC(100)

Diseases : Pneumonia : CK(330) : AC(40)

Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1015) : AC(343)

Docosahexaenoic acid (DHA) supplementation may correct a fatty acid deficiency and reduce rod ERG functional loss in X-linked retinitis pigmentosa.

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Pubmed Data : Am J Ophthalmol. 2004 Apr;137(4):704-18. PMID: 15059710

Article Published Date : Apr 01, 2004

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid) : CK(562) : AC(100)

Diseases : Retinitis Pigmentosa : CK(50) : AC(5)

Docosahexaenoic acid intake may be associated with a reduced prevalence of atopic eczema in pregnant Japanese females.

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Pubmed Data : Asia Pac J Clin Nutr. 2008;17(4):612-9. PMID: 19114399

Article Published Date : Jan 01, 2008

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid) : CK(562) : AC(100)

Diseases : Atopic Dermatitis: Infant & Childhood : CK(170) : AC(14), Prenatal Nutrition: Prevention of Problems : CK(355) : AC(38)

EPA and DHA have therapeutic value in the treatment of systemic lupus erythmeatosus.

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Pubmed Data : Prostaglandins Leukot Essent Fatty Acids. 1997 Mar;56(3):193-8. PMID: 9089797

Article Published Date : Mar 01, 1997

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid) : CK(562) : AC(100), EPA (Eicosapentaenoic Acid) : CK(575) : AC(84)

Diseases : Lupus Erythematosus: Systemic : CK(949) : AC(53), Systemic Lupus Erythematosus : CK(387) : AC(54)

EPA and DHA induces prolonged remission of systemic lupus erythematosus without side effects.

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Pubmed Data : Prostaglandins Leukot Essent Fatty Acids. 1994 Sep;51(3):207-13. PMID: 7824535

Article Published Date : Sep 01, 1994

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid) : CK(562) : AC(100), EPA (Eicosapentaenoic Acid) : CK(575) : AC(84)

Diseases : Lupus Erythematosus: Systemic : CK(949) : AC(53)

EPA and DHA may have a therapeutic effect in patients with psoriasis and psoriatic arthritis.

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Pubmed Data : J Int Med Res. 1990 Jan-Feb;18(1):68-73. PMID: 2139859

Article Published Date : Jan 01, 1990

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid) : CK(562) : AC(100), EPA (Eicosapentaenoic Acid) : CK(575) : AC(84)

Diseases : Psoriasis : CK(270) : AC(42), Psoriatic Arthritis : CK(60) : AC(6)

EPA has therapeutic value in children with inattention, hyperactivity, and other disruptive behaviors.

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Pubmed Data : Lipids. 2003 Oct;38(10):1007-21. PMID: 14669965

Article Published Date : Oct 01, 2003

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid) : CK(562) : AC(100), EPA (Eicosapentaenoic Acid) : CK(575) : AC(84), Essential Fatty Acids : CK(88) : AC(12), Gamma-Linoleic Acid (GLA) : CK(76) : AC(17)

Diseases : Attention Deficit Disorder : CK(452) : AC(15), Attention Deficit Disorder with Hyperactivity : CK(278) : AC(32)

EPA/DHA improve plasma phospholipids and behavior in children with ADHD.

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Pubmed Data : Chem Biol Interact. 2008 Nov 25;176(2-3):121-8. Epub 2008 Aug 3. PMID: 17629918

Article Published Date : Nov 25, 2008

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid) : CK(562) : AC(100), EPA (Eicosapentaenoic Acid) : CK(575) : AC(84)

Diseases : Attention Deficit Disorder with Hyperactivity : CK(278) : AC(32)

Fish oil improves tubular dysfunction, lipid profiles and oxidative stress in patients with IgA nephropathy.

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Pubmed Data : J Med Assoc Thai. 2004 Feb;87(2):143-9. PMID: 15061297

Article Published Date : Feb 01, 2004

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid) : CK(562) : AC(100), EPA (Eicosapentaenoic Acid) : CK(575) : AC(84), Fish Oil : CK(613) : AC(94)

Diseases : IgA Nephropathy : CK(186) : AC(22), Oxidative Stress : CK(1867) : AC(710)

Fish oil supplementation has a significant therapeutic effect on children with autism.

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Pubmed Data : Clin Biochem. 2008 Sep;41(13):1044-8. Epub 2008 Jun 12. PMID: 18582451

Article Published Date : Sep 01, 2008

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid) : CK(562) : AC(100), EPA (Eicosapentaenoic Acid) : CK(575) : AC(84), Fish Oil : CK(613) : AC(94), Omega-3 Fatty Acids : CK(3255) : AC(319)

Diseases : Autism : CK(1340) : AC(65)

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