DHA (Docosahexaenoic Acid)

DHA (Docosahexaenoic Acid)

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View the Evidence: Substances

Higher plasma concentrations of EPA and DPA are associated with a lower risk of nonfatal myocardial infarction among women.

Pubmed Data : Am J Clin Nutr. 2008 Jul;88(1):216-23. PMID: 18614744
Article Published Date : Jul 01, 2008
Study Type : Meta Analysis
Additional Links
Substances : DHA (Docosahexaenoic Acid) : CK(582) : AC(100), EPA (Eicosapentaenoic Acid) : CK(595) : AC(84), Fish Oil : CK(615) : AC(95), Omega-3 Fatty Acids : CK(3333) : AC(319)
Diseases : Myocardial Infarction : CK(2632) : AC(117), Myocardial Infarction: Prevention : CK(54) : AC(3)

"Conversion of alpha-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women."

Pubmed Data : Br J Nutr. 2002 Oct ;88(4):411-20. PMID: 12323090
Article Published Date : Sep 30, 2002
Study Type : Human Study
Additional Links
Substances : ALA (Alpha-Linolenic Acid) : CK(48) : AC(8), DHA (Docosahexaenoic Acid) : CK(582) : AC(100), EPA (Eicosapentaenoic Acid) : CK(595) : AC(84), Omega-3 Fatty Acids : CK(3333) : AC(319)
Diseases : Omega-3 Fatty Acid Deficiency : CK(20) : AC(1)
Additional Keywords : Gender Differences : CK(63) : AC(8), Gender Differences: fatty acid metabolism, omega-3 fatty acid metabolism

A "very low dose" of omega-3 fatty acids slows renal progression in high-risk patients with IgA nephropathy.

Pubmed Data : Ren Fail. 2004 Jul;26(4):453-9. PMID: 15462115
Article Published Date : Jul 01, 2004
Study Type : Human Study
Additional Links
Substances : DHA (Docosahexaenoic Acid) : CK(582) : AC(100), EPA (Eicosapentaenoic Acid) : CK(595) : AC(84), Omega-3 Fatty Acids : CK(3333) : AC(319)
Diseases : IgA Nephropathy : CK(186) : AC(22)
Pharmacological Actions : Renoprotective : CK(191) : AC(90)

A 12-month therapy with omega-3 fatty acids improves renal vascular function and tubule function in IgA nephropathy patients.

Pubmed Data : Am J Nephrol. 2004 Sep-Oct;24(5):474-82. Epub 2004 Sep 1. PMID: 15340256
Article Published Date : Sep 01, 2004
Study Type : Human Study
Additional Links
Substances : DHA (Docosahexaenoic Acid) : CK(582) : AC(100), EPA (Eicosapentaenoic Acid) : CK(595) : AC(84), Omega-3 Fatty Acids : CK(3333) : AC(319)
Pharmacological Actions : Renoprotective : CK(191) : AC(90)

A deficiency of omega-3 fatty acids may play a role in the pathophysiology of bipolar disorder in children and adolescents.

Pubmed Data : Lipids. 2008 Nov;43(11):1031-8. Epub 2008 Sep 10. PMID: 18781353
Article Published Date : Nov 01, 2008
Study Type : Human Study
Additional Links
Substances : DHA (Docosahexaenoic Acid) : CK(582) : AC(100), EPA (Eicosapentaenoic Acid) : CK(595) : AC(84), Omega-3 Fatty Acids : CK(3333) : AC(319)
Diseases : Bipolar Disorder : CK(158) : AC(18)

A moderate intake of EPA and DHA may postpone cognitive decline in elderly men.

Pubmed Data : Am J Clin Nutr. 2007 Apr;85(4):1142-7. PMID: 17413117
Article Published Date : Apr 01, 2007
Study Type : Human Study
Additional Links
Substances : DHA (Docosahexaenoic Acid) : CK(582) : AC(100), EPA (Eicosapentaenoic Acid) : CK(595) : AC(84), Omega-3 Fatty Acids : CK(3333) : AC(319)
Diseases : Cognitive Decline/Dysfunction : CK(522) : AC(87), Elderly: Age Specific Diseases : CK(442) : AC(37)
Pharmacological Actions : Neuroprotective Agents : CK(962) : AC(480)
Additional Keywords : Risk Reduction : CK(1909) : AC(196)

An 8-month treatment with omega-3 fatty acids (EPA and DHA) has a positive effects, such as decreasing inflammation, in patients with cystic fibrosis.

Pubmed Data : JPEN J Parenter Enteral Nutr. 2003 Jan-Feb;27(1):52-7. PMID: 12549599
Article Published Date : Jan 01, 2003
Study Type : Human Study
Additional Links
Substances : DHA (Docosahexaenoic Acid) : CK(582) : AC(100), EPA (Eicosapentaenoic Acid) : CK(595) : AC(84)
Diseases : Cystic Fibrosis : CK(703) : AC(77)

An increased concentration of omega-3 fatty acids in serum (especially DHA), a marker of fish or fish oil consumption, may protect against atrial fibrillation in men.

Pubmed Data : Circulation. 2009 Dec 8;120(23):2315-21. Epub 2009 Nov 23. PMID: 19933935
Article Published Date : Dec 08, 2009
Study Type : Human Study
Additional Links
Substances : DHA (Docosahexaenoic Acid) : CK(582) : AC(100), Fish Oil : CK(615) : AC(95)
Diseases : Atrial Fibrillation : CK(441) : AC(45)

Both lower DHA content in mothers' milk and lower seafood consumption were associated with higher rates of postpartum depression.

Pubmed Data : J Affect Disord. 2002 May;69(1-3):15-29. PMID: 12103448
Article Published Date : May 01, 2002
Study Type : Human Study
Additional Links
Substances : DHA (Docosahexaenoic Acid) : CK(582) : AC(100), Fish Oil : CK(615) : AC(95)
Diseases : Postpartum Depression : CK(211) : AC(24)

Breastfeeding protects against illness-induced anorexia and is mediated partially by docosahexaenoic acid.

Pubmed Data : Eur J Clin Nutr. 2008 Jan;62(1):32-8. Epub 2007 Feb 21. PMID: 17311056
Article Published Date : Jan 01, 2008
Study Type : Human Study
Additional Links
Substances : Breast Milk : CK(428) : AC(49), DHA (Docosahexaenoic Acid) : CK(582) : AC(100)
Diseases : Anorexia: Illness and Vaccine Induced : CK(10) : AC(1), Vaccine-induced Toxicity : CK(1130) : AC(163)
Therapeutic Actions : Breastfeeding : CK(708) : AC(67)
Pharmacological Actions : Interleukin-1 beta downregulation : CK(177) : AC(70), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Children who were not breastfed or were fed infant formula without docosahexaenoic acid/arachidonic acid supplementation were significantly more likely to have autistic disorder.

Pubmed Data : Int Breastfeed J. 2006;1:16. Epub 2006 Sep 15. PMID: 16978397
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Substances : Breast Milk : CK(428) : AC(49), DHA (Docosahexaenoic Acid) : CK(582) : AC(100)
Diseases : Autism : CK(1262) : AC(65), Autism Spectrum Disorders : CK(1140) : AC(108)
Therapeutic Actions : Breastfeeding : CK(708) : AC(67)

Data support pro- and anti-inflammatory roles within EFA metabolism

Pubmed Data : Prostaglandins Leukot Essent Fatty Acids. 1998 Oct ;59(4):239-45. PMID: 9849649
Article Published Date : Sep 30, 1998
Study Type : Human Study
Additional Links
Substances : DHA (Docosahexaenoic Acid) : CK(582) : AC(100), Essential Fatty Acids : CK(88) : AC(12)
Diseases : Sjogren's Syndrome : CK(81) : AC(14)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433)
Additional Keywords : cell membranes, essential fatty acids, sjogrens syndrome

DHA (Docosahexaenoic Acid) significantly enhances the activity of neutrophils and monocytes.

Pubmed Data : Clin Nutr. 2006 Dec;25(6):923-38. Epub 2006 May 11. PMID: 16697494
Article Published Date : Dec 01, 2006
Study Type : Human Study
Additional Links
Substances : DHA (Docosahexaenoic Acid) : CK(582) : AC(100)
Diseases : Neutropenia : CK(90) : AC(22), Neutropenia: Chemotherapy Induced : CK(82) : AC(17), Neutropenia: Cyclic : CK(48) : AC(16), Neutropenia: Severe Congenital : CK(16) : AC(7)

DHA appears to be a conditional essential substrate for children with PKU, significantlty improving coutcomes in a test of motor function and coordination.

Pubmed Data : J Pediatr Gastroenterol Nutr. 2009 Mar;48 Suppl 1:S2-7. PMID: 19214054
Article Published Date : Mar 01, 2009
Study Type : Human Study
Additional Links
Substances : DHA (Docosahexaenoic Acid) : CK(582) : AC(100), Omega-3 Fatty Acids : CK(3333) : AC(319)
Diseases : Phenylketonurias : CK(40) : AC(4)

DHA intake during pregnancy and postpartum may reduce depressive symptoms.

Pubmed Data : Prostaglandins Leukot Essent Fatty Acids. 2003 Oct;69(4):237-43. PMID: 12907133
Article Published Date : Oct 01, 2003
Study Type : Human Study
Additional Links
Substances : DHA (Docosahexaenoic Acid) : CK(582) : AC(100), Omega-3 Fatty Acids : CK(3333) : AC(319)
Diseases : Postpartum Depression : CK(211) : AC(24)

DHA may have antiadhesion effects.

Pubmed Data : Fertil Steril. 2007 Dec;88(6):1657-62. Epub 2007 May 4. PMID: 17482172
Article Published Date : Dec 01, 2007
Study Type : Human Study
Additional Links
Substances : DHA (Docosahexaenoic Acid) : CK(582) : AC(100)
Diseases : Abdominal Adhesions : CK(48) : AC(9)

DHA supplementation reduces the production of inflammatory mediators and decreases the adverse effect of infection on appetite.

Pubmed Data : Rev Med Inst Mex Seguro Soc. 2006 Jan-Feb;44(1):5-11. PMID: 116497254
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Substances : DHA (Docosahexaenoic Acid) : CK(582) : AC(100)
Diseases : Pneumonia : CK(330) : AC(40)
Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Docosahexaenoic acid (DHA) supplementation may correct a fatty acid deficiency and reduce rod ERG functional loss in X-linked retinitis pigmentosa.

Pubmed Data : Am J Ophthalmol. 2004 Apr;137(4):704-18. PMID: 15059710
Article Published Date : Apr 01, 2004
Study Type : Human Study
Additional Links
Substances : DHA (Docosahexaenoic Acid) : CK(582) : AC(100)
Diseases : Retinitis Pigmentosa : CK(50) : AC(5)

Docosahexaenoic acid intake may be associated with a reduced prevalence of atopic eczema in pregnant Japanese females.

Pubmed Data : Asia Pac J Clin Nutr. 2008;17(4):612-9. PMID: 19114399
Article Published Date : Jan 01, 2008
Study Type : Human Study
Additional Links
Substances : DHA (Docosahexaenoic Acid) : CK(582) : AC(100)
Diseases : Atopic Dermatitis: Infant & Childhood : CK(170) : AC(14), Prenatal Nutrition: Prevention of Problems : CK(357) : AC(41)

Eicosapentaenoic and docosapentaenoic acids are the principal products of alpha-linolenic acid metabolism in young men

Pubmed Data : Br J Nutr. 2002 Oct ;88(4):355-63. PMID: 12323085
Article Published Date : Sep 30, 2002
Study Type : Human Study
Additional Links
Substances : ALA (Alpha-Linolenic Acid) : CK(48) : AC(8), DHA (Docosahexaenoic Acid) : CK(582) : AC(100), EPA (Eicosapentaenoic Acid) : CK(595) : AC(84)
Diseases : Omega-3 Fatty Acid Deficiency : CK(20) : AC(1)
Additional Keywords : omega-3 fatty acid metabolism

EPA and DHA have therapeutic value in the treatment of systemic lupus erythmeatosus.

Pubmed Data : Prostaglandins Leukot Essent Fatty Acids. 1997 Mar;56(3):193-8. PMID: 9089797
Article Published Date : Mar 01, 1997
Study Type : Human Study
Additional Links
Substances : DHA (Docosahexaenoic Acid) : CK(582) : AC(100), EPA (Eicosapentaenoic Acid) : CK(595) : AC(84)
Diseases : Lupus Erythematosus: Systemic : CK(949) : AC(53), Systemic Lupus Erythematosus : CK(387) : AC(54)

EPA and DHA induces prolonged remission of systemic lupus erythematosus without side effects.

Pubmed Data : Prostaglandins Leukot Essent Fatty Acids. 1994 Sep;51(3):207-13. PMID: 7824535
Article Published Date : Sep 01, 1994
Study Type : Human Study
Additional Links
Substances : DHA (Docosahexaenoic Acid) : CK(582) : AC(100), EPA (Eicosapentaenoic Acid) : CK(595) : AC(84)
Diseases : Lupus Erythematosus: Systemic : CK(949) : AC(53)

EPA and DHA may have a therapeutic effect in patients with psoriasis and psoriatic arthritis.

Pubmed Data : J Int Med Res. 1990 Jan-Feb;18(1):68-73. PMID: 2139859
Article Published Date : Jan 01, 1990
Study Type : Human Study
Additional Links
Substances : DHA (Docosahexaenoic Acid) : CK(582) : AC(100), EPA (Eicosapentaenoic Acid) : CK(595) : AC(84)
Diseases : Psoriasis : CK(270) : AC(42), Psoriatic Arthritis : CK(60) : AC(6)

EPA has therapeutic value in children with inattention, hyperactivity, and other disruptive behaviors.

Pubmed Data : Lipids. 2003 Oct;38(10):1007-21. PMID: 14669965
Article Published Date : Oct 01, 2003
Study Type : Human Study
Additional Links
Substances : DHA (Docosahexaenoic Acid) : CK(582) : AC(100), EPA (Eicosapentaenoic Acid) : CK(595) : AC(84), Essential Fatty Acids : CK(88) : AC(12), Gamma-Linoleic Acid (GLA) : CK(76) : AC(17)
Diseases : Attention Deficit Disorder : CK(134) : AC(12), Attention Deficit Disorder with Hyperactivity : CK(240) : AC(30)

EPA/DHA improve plasma phospholipids and behavior in children with ADHD.

Pubmed Data : Chem Biol Interact. 2008 Nov 25;176(2-3):121-8. Epub 2008 Aug 3. PMID: 17629918
Article Published Date : Nov 25, 2008
Study Type : Human Study
Additional Links
Substances : DHA (Docosahexaenoic Acid) : CK(582) : AC(100), EPA (Eicosapentaenoic Acid) : CK(595) : AC(84)
Diseases : Attention Deficit Disorder with Hyperactivity : CK(240) : AC(30)

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